芹菜籽油的提取纯化及降血脂功能研究
|
摘要
芹菜籽为伞形花科草本植物芹菜(Apium graveolens Linn)的种子,在我国资源丰富,且尚未得到合理的有效利用。研究表明,芹菜籽中油脂含量丰富,含有多种药理活性成分,具有散气、消肿、利尿、抗肿瘤、抗衰老等功效。本文采用在我国产量最高的旱芹菜籽为试验原料,对其萃取出的芹菜籽油进行系统的研究,确定最佳的制备技术路线,并明确其生理活性,为更好的开发和利用芹菜籽资源提供理论依据。
本文通过有机溶剂法、同时水蒸气蒸馏法和超临界流体萃取法研究芹菜籽油的提取工艺;采用分子蒸馏技术分离轻重组分纯化芹菜籽油;研究了芹菜籽油的理化性质和氧化稳定性,分析其营养成分;将芹菜籽油微胶囊化;通过动物实验评价芹菜籽油的毒理安全性,研究了芹菜籽油对高脂大鼠的血脂调节作用,并探讨其作用机理。主要研究结论如下:
1、芹菜籽中粗脂肪含量达19.05%;含有19种基本氨基酸,总氨基酸含量230.569mg/g,8种必需氨基酸均含有,以谷氨酸含量最高;原子吸收光谱分析芹菜籽中矿物元素钾含量高达8.6mg/g,镁含量为1.0mg/g,钠、铁含量也比较丰富。
2、有机溶剂法提取芹菜籽油最佳工艺条件为:粒度60目、液料比3∶1、浸泡48h、旋转蒸发温度50℃,提取率达11.47%。同时水蒸气蒸馏法最佳工艺条件为:粒度60目、液料比8∶1、浸泡时间12h、蒸馏时间8h,提取率为4.36%。超临界流体萃取法响应面优化工艺条件为:粒度60目、萃取压力21MPa、萃取温度46℃、CO_2流量16L/h、分离温度30℃、每次进料300g、萃取2h,工艺优化后芹菜籽油提取率达12.04%。
3、分子蒸馏纯化芹菜籽油响应面法优化工艺条件为:进料温度50℃、蒸发温度111℃、刮膜转速214r/min、进料速率1.6mL/min,在此优化条件下重组分馏出物收率达71.08%。气质联用分析分子蒸馏后芹菜籽油主要成分和相对含量,共鉴定出占总成分91.6%的19种主要成分。轻组分化合物被分离在蒸出物中,而不饱和脂肪酸、丁基苯酞、瑟单内酯、角鲨烯等有效成分则分离在重组分馏出物中,且相对含量均有提高。
4、芹菜籽油中不饱和脂肪酸含量丰富,不稳定。温度、时间、空气和光照可加速芹菜籽油的氧化速度。加入抗氧化剂可有效延缓氧化速度,四种抗氧化剂抗氧化性顺序为TBHQ＞PG＞BHT＞BHA,以抗坏血酸增效,抗氧化效果更好。与Cu~(2+)、Fe~(3+)两种金属离子接触,芹菜籽油过氧化值明显升高,Cu~(2+)的影响更大。芹菜籽油应尽量在低温、隔绝空气、避光条件下保存,避免与金属离子的接触,为延长贮藏期可适当加入抗氧化剂。
5、气相色谱法测定芹籽油中棕榈酸、硬脂酸、油酸、亚油酸,亚麻酸、花生酸组成及含量,在优化的色谱条件下,六种不饱和脂肪酸达到基线分离,结果表明芹菜籽油中棕榈酸的含量为92.86mg/g,硬脂酸含量为8.46mg/g,油酸含量为98.71mg/g,亚油酸的含量为283.24mg/g,亚麻酸的含量为19.69mg/g,花生酸的含量为34.28mg/g。反相高效液相色谱检测芹菜籽油中6-维生素E含量为86.9μg/g,γ-维生素E含量为120.6μg/g,β-维生素E含量为69.7μg/g,α-维生素E含量为132.5μg/g。
6、以β-环糊精和明胶为复合壁材微胶囊化芹菜籽油的最佳壁材配方为:芯材占壁材含量24.70%,β-环糊精/明胶3.03倍,固形物浓度18.82%,乳化剂用量0.75%。以最优壁材配方包埋芹菜籽油,通过工艺优化模型得出最佳微胶囊化芹菜籽油的喷雾干燥工艺参数为32MPa压力下均质3次、进风温度181℃、出风温度80℃,在此条件下,芹菜籽油的微胶囊化效率达到92.11%,产率为84.46%。制备的微胶囊化芹菜籽油产品溶解性良好,模拟胃液中60min释放率可达90%以上,贮藏稳定性明显优于液态芹菜籽油,电镜扫描观察微胶囊结构均匀呈球形。红外光谱分析微胶囊化前后芹菜籽油的成分基本保留。
7、芹菜籽油对小鼠经口LD_(50)＞10.00g/kg体重,Ames试验、小鼠骨髓微核试验结果均为阴性。所测芹菜籽油属实际无毒级,是安全的。
8、与高脂模型组比,灌胃不同剂量芹菜籽油显著降低大鼠血清的总胆固醇(TC)、总甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平和载脂蛋白B(ApoB)含量,显著提高高密度脂蛋白胆固醇(HDL-C)水平和载脂蛋白A(ApoA I)含量,动脉硬化指数LDL-C/HDL-C显著下降;能有效防止高脂饮食引起的肝脏脂肪变性及细胞坏死,且呈一定剂量依赖关系;并使高脂血症大鼠血清和肝脏的SOD活性显著提高,脂质过氧化物MDA含量显著下降,且呈现一定的剂量依赖性。表明芹菜籽油能增强抗氧化酶活性,减少自由基的产生,防止脂质过氧化及其中间代谢产物对机体的损害,可以有效提高高脂血症大鼠体内的抗氧化水平,从而改善血脂代谢。
综上所述,本论文系统的研究了制备芹菜籽油的工艺条件,分析芹菜籽油中的活性成分,明确了其降血脂的生理功能,为芹菜籽油的工业化生产提供切实可行的理论依据。
Celery seed is the seed of umbelliferae herbage apium.There have abundant resources in our country.Celery seeds are not reasonable and effective to be used.Studies have shown that celery seeds contain abundant oil and pharmacological activities ingredients.Celery seeds have the efficacy on scatter chi,detumescence,diuresis,antitumor,anti-aging and etc.The test selected the celery seeds that had the most output in our country.Celery seeds oil(CSO) was systematic studied.It was very important that determined the technology pathway and its bioactivities to provide theoretical support for developing and utilizing the resources of celery seeds.
In this paper,celery seeds oil was extracted by organic solvent extraction(SE), simultaneous water distillation-solvent extraction(SDE)and supercritical carbon dioxide fluid extraction(SFE-CO_2).The light component and weighty component were separated by molecular distillation purification.The physicochemical property and oxidative stability were tested.Nutrient content and ingredients were identified.Microencapsulation CSO was studied. The toxicological evaluation was completed.And the effects of CSO on hypolipidemic and mechanism in hyperlipidemic rats were studied by animal experiment.The main results were as follows:
1.The content of crude fat from celery seeds was 19.05%.Celery seed contained 19 kind amino acids including 8 kind sessential amino acids.The content of total amino acid was 230.569mg/g,and the highest content was glutamic acid.Through the analysis by atomic absorption spectrum,the content of mineral elements K was 8.6mg/g,the content of Mg was l.0mg/g.In addition,the content of Na and Fe were plentiful.
2.The optimum technical conditions by SE were:granularity was 60 mesh size,liquid seeds ratio was 3:1,soaking time was 48h,evaporation temperature was 50℃.Under these conditions,the extraction yield was 11.47%.The optimum technical conditions by SDE were: granularity was 60 mesh size,liquid seeds ratio was 8:1,soaking time was 12h,distilling time was 8h.Under the conditions,the extraction yield was 4.36%.The optimum response surface technical conditions by SE were:granularity was 60 mesh size,extraction pressure was 21MPa,extraction temperature was 46℃,flow rate of CO_2 was 16L/h,separation temperature was 30℃,incoming stock was 300g every time,extraction time was 2h.Under the optimize conditions,the extraction yield of CSO was 12.04%.
3.The response surface optimum technical conditions by molecular distillation were: charging temperature was 50℃,distillation temperature was 111℃,rotating speed was 214r/min,charging rate was 1.6mL/min.Under these optimize conditions,the yield of weighty constituents distillate was 71.08%.Through analyzing the main constituents of CSO by GC/MS,main components of 91.6%were identified,it included 19 kinds compound.The light constituents were separated as evaporant.The active ingredients including unsaturated fatty acid,NBP,Squalene and etc were separated in weighty constituent distillate.And the relative contents were increased.
4.Celery seeds oil contained plentiful unsaturated fatty acid,it was instability.Some external conditions such as temperature,time,oxygen and light could accelerate the oxidation rate.The oxidation rate could defer by adding in some antioxidants.The sequence of inoxidability measurement was:TBHQ＞PG＞BHT＞BHA.The oxidation resistance effect was increased by adding ascorbic acid as synergistic agent.If celery seeds oil was in touch with Cu~(2+),Fe~(3+),the peroxide number would increase obviously.The influence of Cu~(2+)was greater. Therefore,the CSO should be preserved at lower temperature,and should avoid touching oxygen,light,metallic ion.In order to prolonging the storage life of CSO,it should be appended right amount antioxidant.
5.The content of unsaturated fatty acid including hexadecanoic acid,stearic acid,oleic acid,linoleic acid,linolenic acid,arachidic acid was determined by GC.The optimum chromatogram conditions,it achieved baseline separation.The content of hexadecanoic acid was 92.86mg/g,content of stearic acid was 8.46mg/g,content of oleic acid was 98.71mg/g, content of linoleic acid was 283.24mg/g,content of linolenic acid was 19.69mg/g,content of arachidic acid was 34.28mg/g.The content ofδ-V_E was 86.9μg/g,content ofγ-V_E was 120.6μg/g,content ofβ-V_e was 69.7μg/g,content ofα-V_E was 132.5μg/g.
6.Glutin and p-CD were selected as complex wall material to embed celery seeds oil. The optimum prescription of wall material was:rate of core material to wall material was 24.70%,β-CD/glutin was 3.03,total solid concentration was 18.82%,content of emulsifier was 0.75%.The response surface optimum technical conditions of sponging drying were: homogeneity pressure was 32MPa,homogeneity times were there,Inlet air temperature was 181℃,Outlet air temperature was 80℃.Under the optimize conditions,the microencapsulation efficiency was 92.11%,the output was84.46%.The solubility of microcapsule product was well.The release rate in simulation gastric juice could attain 90% after 60min.Storge stability of microcapsule product excelled liquid state CSO.The microcapsule product was globose and its structure was well-distributed.Its ingredients were retained fundamentally by infrared spectrum analysis.
7.The irritable toxicology test indicated LD_(50)＞10.00g/kg.The results of Ames test and micronucleus test of bone marrow cell were feminine.So the CSO belonged to innocuity grade.
8.The serum TG,TC,LDL-C concentration,ApoB content and atherosclerosis index in rats fed with CSO were significantly lower than those in model group,while serum HDL-C concentration and ApoA I content were higher.CSO could prevent steatosis and cytoclasis causing by high fat diet,and it had dose-dependent.Comparing with model group,SOD activity were increased significantly in serum and liver by feeding with CSO.MDA content were decreased in serum and liver.CSO could increase antioxidase activity,decrease the freeradical.prevent the harm of lipid peroxide and intermediary metabolism.CSO could improve oxidation resistance level of hyperlipemia rats and regulate blood lipid metabolism.
As we had seen,the test studied systematically the manufacture technology condition of CSO,analysised its bioactivities ingredients,and determined the hypolipidemic function.The study could provide theoretical support for industrial production of CSO.
本文通过有机溶剂法、同时水蒸气蒸馏法和超临界流体萃取法研究芹菜籽油的提取工艺;采用分子蒸馏技术分离轻重组分纯化芹菜籽油;研究了芹菜籽油的理化性质和氧化稳定性,分析其营养成分;将芹菜籽油微胶囊化;通过动物实验评价芹菜籽油的毒理安全性,研究了芹菜籽油对高脂大鼠的血脂调节作用,并探讨其作用机理。主要研究结论如下:
1、芹菜籽中粗脂肪含量达19.05%;含有19种基本氨基酸,总氨基酸含量230.569mg/g,8种必需氨基酸均含有,以谷氨酸含量最高;原子吸收光谱分析芹菜籽中矿物元素钾含量高达8.6mg/g,镁含量为1.0mg/g,钠、铁含量也比较丰富。
2、有机溶剂法提取芹菜籽油最佳工艺条件为:粒度60目、液料比3∶1、浸泡48h、旋转蒸发温度50℃,提取率达11.47%。同时水蒸气蒸馏法最佳工艺条件为:粒度60目、液料比8∶1、浸泡时间12h、蒸馏时间8h,提取率为4.36%。超临界流体萃取法响应面优化工艺条件为:粒度60目、萃取压力21MPa、萃取温度46℃、CO_2流量16L/h、分离温度30℃、每次进料300g、萃取2h,工艺优化后芹菜籽油提取率达12.04%。
3、分子蒸馏纯化芹菜籽油响应面法优化工艺条件为:进料温度50℃、蒸发温度111℃、刮膜转速214r/min、进料速率1.6mL/min,在此优化条件下重组分馏出物收率达71.08%。气质联用分析分子蒸馏后芹菜籽油主要成分和相对含量,共鉴定出占总成分91.6%的19种主要成分。轻组分化合物被分离在蒸出物中,而不饱和脂肪酸、丁基苯酞、瑟单内酯、角鲨烯等有效成分则分离在重组分馏出物中,且相对含量均有提高。
4、芹菜籽油中不饱和脂肪酸含量丰富,不稳定。温度、时间、空气和光照可加速芹菜籽油的氧化速度。加入抗氧化剂可有效延缓氧化速度,四种抗氧化剂抗氧化性顺序为TBHQ＞PG＞BHT＞BHA,以抗坏血酸增效,抗氧化效果更好。与Cu~(2+)、Fe~(3+)两种金属离子接触,芹菜籽油过氧化值明显升高,Cu~(2+)的影响更大。芹菜籽油应尽量在低温、隔绝空气、避光条件下保存,避免与金属离子的接触,为延长贮藏期可适当加入抗氧化剂。
5、气相色谱法测定芹籽油中棕榈酸、硬脂酸、油酸、亚油酸,亚麻酸、花生酸组成及含量,在优化的色谱条件下,六种不饱和脂肪酸达到基线分离,结果表明芹菜籽油中棕榈酸的含量为92.86mg/g,硬脂酸含量为8.46mg/g,油酸含量为98.71mg/g,亚油酸的含量为283.24mg/g,亚麻酸的含量为19.69mg/g,花生酸的含量为34.28mg/g。反相高效液相色谱检测芹菜籽油中6-维生素E含量为86.9μg/g,γ-维生素E含量为120.6μg/g,β-维生素E含量为69.7μg/g,α-维生素E含量为132.5μg/g。
6、以β-环糊精和明胶为复合壁材微胶囊化芹菜籽油的最佳壁材配方为:芯材占壁材含量24.70%,β-环糊精/明胶3.03倍,固形物浓度18.82%,乳化剂用量0.75%。以最优壁材配方包埋芹菜籽油,通过工艺优化模型得出最佳微胶囊化芹菜籽油的喷雾干燥工艺参数为32MPa压力下均质3次、进风温度181℃、出风温度80℃,在此条件下,芹菜籽油的微胶囊化效率达到92.11%,产率为84.46%。制备的微胶囊化芹菜籽油产品溶解性良好,模拟胃液中60min释放率可达90%以上,贮藏稳定性明显优于液态芹菜籽油,电镜扫描观察微胶囊结构均匀呈球形。红外光谱分析微胶囊化前后芹菜籽油的成分基本保留。
7、芹菜籽油对小鼠经口LD_(50)＞10.00g/kg体重,Ames试验、小鼠骨髓微核试验结果均为阴性。所测芹菜籽油属实际无毒级,是安全的。
8、与高脂模型组比,灌胃不同剂量芹菜籽油显著降低大鼠血清的总胆固醇(TC)、总甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平和载脂蛋白B(ApoB)含量,显著提高高密度脂蛋白胆固醇(HDL-C)水平和载脂蛋白A(ApoA I)含量,动脉硬化指数LDL-C/HDL-C显著下降;能有效防止高脂饮食引起的肝脏脂肪变性及细胞坏死,且呈一定剂量依赖关系;并使高脂血症大鼠血清和肝脏的SOD活性显著提高,脂质过氧化物MDA含量显著下降,且呈现一定的剂量依赖性。表明芹菜籽油能增强抗氧化酶活性,减少自由基的产生,防止脂质过氧化及其中间代谢产物对机体的损害,可以有效提高高脂血症大鼠体内的抗氧化水平,从而改善血脂代谢。
综上所述,本论文系统的研究了制备芹菜籽油的工艺条件,分析芹菜籽油中的活性成分,明确了其降血脂的生理功能,为芹菜籽油的工业化生产提供切实可行的理论依据。
Celery seed is the seed of umbelliferae herbage apium.There have abundant resources in our country.Celery seeds are not reasonable and effective to be used.Studies have shown that celery seeds contain abundant oil and pharmacological activities ingredients.Celery seeds have the efficacy on scatter chi,detumescence,diuresis,antitumor,anti-aging and etc.The test selected the celery seeds that had the most output in our country.Celery seeds oil(CSO) was systematic studied.It was very important that determined the technology pathway and its bioactivities to provide theoretical support for developing and utilizing the resources of celery seeds.
In this paper,celery seeds oil was extracted by organic solvent extraction(SE), simultaneous water distillation-solvent extraction(SDE)and supercritical carbon dioxide fluid extraction(SFE-CO_2).The light component and weighty component were separated by molecular distillation purification.The physicochemical property and oxidative stability were tested.Nutrient content and ingredients were identified.Microencapsulation CSO was studied. The toxicological evaluation was completed.And the effects of CSO on hypolipidemic and mechanism in hyperlipidemic rats were studied by animal experiment.The main results were as follows:
1.The content of crude fat from celery seeds was 19.05%.Celery seed contained 19 kind amino acids including 8 kind sessential amino acids.The content of total amino acid was 230.569mg/g,and the highest content was glutamic acid.Through the analysis by atomic absorption spectrum,the content of mineral elements K was 8.6mg/g,the content of Mg was l.0mg/g.In addition,the content of Na and Fe were plentiful.
2.The optimum technical conditions by SE were:granularity was 60 mesh size,liquid seeds ratio was 3:1,soaking time was 48h,evaporation temperature was 50℃.Under these conditions,the extraction yield was 11.47%.The optimum technical conditions by SDE were: granularity was 60 mesh size,liquid seeds ratio was 8:1,soaking time was 12h,distilling time was 8h.Under the conditions,the extraction yield was 4.36%.The optimum response surface technical conditions by SE were:granularity was 60 mesh size,extraction pressure was 21MPa,extraction temperature was 46℃,flow rate of CO_2 was 16L/h,separation temperature was 30℃,incoming stock was 300g every time,extraction time was 2h.Under the optimize conditions,the extraction yield of CSO was 12.04%.
3.The response surface optimum technical conditions by molecular distillation were: charging temperature was 50℃,distillation temperature was 111℃,rotating speed was 214r/min,charging rate was 1.6mL/min.Under these optimize conditions,the yield of weighty constituents distillate was 71.08%.Through analyzing the main constituents of CSO by GC/MS,main components of 91.6%were identified,it included 19 kinds compound.The light constituents were separated as evaporant.The active ingredients including unsaturated fatty acid,NBP,Squalene and etc were separated in weighty constituent distillate.And the relative contents were increased.
4.Celery seeds oil contained plentiful unsaturated fatty acid,it was instability.Some external conditions such as temperature,time,oxygen and light could accelerate the oxidation rate.The oxidation rate could defer by adding in some antioxidants.The sequence of inoxidability measurement was:TBHQ＞PG＞BHT＞BHA.The oxidation resistance effect was increased by adding ascorbic acid as synergistic agent.If celery seeds oil was in touch with Cu~(2+),Fe~(3+),the peroxide number would increase obviously.The influence of Cu~(2+)was greater. Therefore,the CSO should be preserved at lower temperature,and should avoid touching oxygen,light,metallic ion.In order to prolonging the storage life of CSO,it should be appended right amount antioxidant.
5.The content of unsaturated fatty acid including hexadecanoic acid,stearic acid,oleic acid,linoleic acid,linolenic acid,arachidic acid was determined by GC.The optimum chromatogram conditions,it achieved baseline separation.The content of hexadecanoic acid was 92.86mg/g,content of stearic acid was 8.46mg/g,content of oleic acid was 98.71mg/g, content of linoleic acid was 283.24mg/g,content of linolenic acid was 19.69mg/g,content of arachidic acid was 34.28mg/g.The content ofδ-V_E was 86.9μg/g,content ofγ-V_E was 120.6μg/g,content ofβ-V_e was 69.7μg/g,content ofα-V_E was 132.5μg/g.
6.Glutin and p-CD were selected as complex wall material to embed celery seeds oil. The optimum prescription of wall material was:rate of core material to wall material was 24.70%,β-CD/glutin was 3.03,total solid concentration was 18.82%,content of emulsifier was 0.75%.The response surface optimum technical conditions of sponging drying were: homogeneity pressure was 32MPa,homogeneity times were there,Inlet air temperature was 181℃,Outlet air temperature was 80℃.Under the optimize conditions,the microencapsulation efficiency was 92.11%,the output was84.46%.The solubility of microcapsule product was well.The release rate in simulation gastric juice could attain 90% after 60min.Storge stability of microcapsule product excelled liquid state CSO.The microcapsule product was globose and its structure was well-distributed.Its ingredients were retained fundamentally by infrared spectrum analysis.
7.The irritable toxicology test indicated LD_(50)＞10.00g/kg.The results of Ames test and micronucleus test of bone marrow cell were feminine.So the CSO belonged to innocuity grade.
8.The serum TG,TC,LDL-C concentration,ApoB content and atherosclerosis index in rats fed with CSO were significantly lower than those in model group,while serum HDL-C concentration and ApoA I content were higher.CSO could prevent steatosis and cytoclasis causing by high fat diet,and it had dose-dependent.Comparing with model group,SOD activity were increased significantly in serum and liver by feeding with CSO.MDA content were decreased in serum and liver.CSO could increase antioxidase activity,decrease the freeradical.prevent the harm of lipid peroxide and intermediary metabolism.CSO could improve oxidation resistance level of hyperlipemia rats and regulate blood lipid metabolism.
As we had seen,the test studied systematically the manufacture technology condition of CSO,analysised its bioactivities ingredients,and determined the hypolipidemic function.The study could provide theoretical support for industrial production of CSO.
引文
1.鲍鲁生.1999.食品工业中应用的微胶囊技术,食品科学,(9):69.
2.毕丽君,李慧.1999.水芹中黄酮类化合物最佳提取工艺的研究.食品科学,12:35-37.
3.毕艳红.2007.分子蒸馏技术分离提纯大蒜精油的研究.山东农业大学硕士学位论文.
4.臣战国,张怀涛,李伟.2008.芹菜籽精油成分以及清除亚硝酸作用.化学与粘合,30(6):38-40.
5.程志清,吴惠勤,张桂英.1989.GC/MS法快速测定食用植物油中脂肪酸含量.分析测试学报,8(16):11-14.
6.董高翔,冯亦璞.1999.丁基苯酞及其光学异构体的抗惊厥作用.中国药理学通报,(01):92-93.
7.董高翔,冯亦璞.2002.丁基苯酞对局部脑缺血再灌注大鼠脑线粒体ATPase,抗氧化酶活性和脂质过氧化的影响.中国医学科学院学报,(01):93-97.
8.董丽花,范增民.2004.不同品种芹菜不同部位微量元素含量研究.微量元素与健康研究,6:70-71.
9.范培军,郭振德,张镜澄等.1995.芹菜籽的超临界CO_2流体萃取物的化学成分研究.天然产物研究与开发,(6):89-92.
10.范伟忠,章荣华.2002.薏苡仁油的毒性研究及安全性评价.上海医学预防杂志,12(4):178-179.
11.方景岩,于才渊,姚辉,朱琳.2005.喷雾干燥制备番茄红素微胶囊.干燥技术与设备,3(1):19-23.
12.方允中,郑荣梁.2002.自由基生物学的理论与应用.北京:科学出版社,60-69.
13.冯卫华.2003.猕猴桃籽油微胶囊化技术研究.西北农林科技大学硕士学位论文.
14.冯武文,杨村.2002.分子蒸馏技术在日化工业中的应用及前景.日用化学工业,6:73-75.
15.傅红,裘爱咏.2002.分子蒸馏法制备鱼油多不饱和脂肪酸田.无锡轻工大学学报,21(6):617-621.
16.高尔,王金红.2001.乳化葛根素对高脂血症家兔血清NO及PC量的影响.潍坊医学院学报,23(1);1-3.
17.高金燕,陈红兵.2005.芹菜籽中活性成分研究进展.中国食物与营养,7:28-31.
18.高金燕,曾小花,王毅辉等.2004.从芹菜中提取黄酮类物质的初步研究.中国食品添加剂,3:19-21.
19.顾冬雨,吕金良,古丽娜·沙比尔,阿吉艾克拜尔·艾萨.2007.高效液相色谱法测定芹菜籽中3-正丁基苯酞的含量.时珍国医国药,18(3):513-514.
20.顾刘金,杨校华,陈琼姜等.2004.SD大鼠脏器正常参考值探讨.浙江省医学科学院学报,57(6):25-27.
21.郭红,陈在嘉,徐义枢.1991.血清脂质与脂质过氧化关系的临床研究.中国循环杂志,6(5):373-375.
22.郭蕾,陈彤,陈哓岚等.2003.芹菜籽挥发油化学成分的研究.河南科学,21(6):728-729.
23.郭美丽,周燕平,何海健等.2008.杜仲籽油毒理学安全性评价.毒理学杂志,22(3):248-249.
24.郭燕.1999.超临界流体萃取的原理和应用.湖北人民出版社.
25.何耀,李良涛,万志恒.1990.冠心病血清载脂蛋白A1和B100的观察.中华心血管病杂志,18(4):217-219.
26.胡庆国.2003.超临界CO_2萃取芹菜籽油的工艺研究.食品研究与开发,24(2):30-31.
27.贾海伦.2008.芹菜黄酮提取及分离纯化工艺研究.黑龙江大学硕士学位论文.
28.李爱民,王玉兰,赵淑兰,赵景辉,王玉方.1997.儿种野生芹菜营养成分分析.特产研究,(03):18-19.
29.李全宏,倪元颖.2002超临界CO_2流体萃取南瓜籽油的质量研究.食品工业科技,23(4):22-25.
30.李雪梅,周谨,张晓龙,杨叶昆,邓国宾.2004.超临界CO_2流体萃取与常规提取方法制备芹菜籽精油的比较.精细化工,21(8):581-585.
31.李艳.2006.核桃油的提取及微胶囊化制备技术的研究.中国农业大学硕士学位论文.
32.李延辉.2005.微胶囊化榛仁油的制备技术及工艺研究.吉林农业大学硕士学位论文.
33.李毅敏,周连发,王士贤.2004.复方益母草膏治疗痛经药理机制的实验研究.中成药,26(4):311-314.
34.李岳.2004.新疆芹菜籽和苦豆子活性成分的药效学、毒理学实验及苦豆子降血脂分子生物学机制研究.中国科学院新疆理化技术研究所硕士学位论文.
35.林红秀,伍培辉,柯于家.1999.超临界CO_2萃取玉米黄色素的研究.郑州粮食学院学报.20(3):57-60.
36.刘冬文.2003.大蒜油的提取及微胶囊化研究.中国农业大学硕士学位论文.
37.刘峰林,王瑞琼,马中山等.2006.当归油治疗痛经的药效学实验研究.现代中药研究与实践,20(6):22-23.
38.刘洛生,娄红祥.任健,郭启雷.2001.安清益智胶囊的质量标准研究.山东医科大学学报,39(6):562-564.
39.刘小光,冯亦璞.1995.丁基苯酞对局部脑缺血大鼠行为和病理改变的保护作用.药学学报,30(10):896-902.
40.刘咏松.2004.芹菜的本草研究及功用.四川中医,22(7):25-26.
41.陆韩涛,程玉镜.1993.芳香油的分子蒸馏提纯.精细化工,10:44-46.
42.陆生椿.汪清泉,郭傅衍.1995.超临界CO_2流体萃取芹菜籽香料的应用技术研究.四川日化,(1):1-3.
43.陆战国.张怀涛,苏荣军.2008.芹菜籽香气成分分析.化学研究,19(2):58-64.
44.吕金良,牟新利,王武宝等.2006.维药芹菜籽化学成分研究.时珍国医国药,17(1):6-7.
45.马海乐.2001a.超临界CO_2萃取技术及其在生物资源开发利用中应用的最新进展(Ⅰ).包装与食品机械.19(20):1-5.
46.马海乐.2001b.超临界CO_2萃取技术及其在生物资源开发利用中应用的最新进展(Ⅱ).包装与食品机械.19(3):7-10,17.
47.马传国,王兴国,张根旺等.2001.分予燕馏对高酸值花椒籽油脱酸的初步探讨.中国油脂,26(3):50-52.
48.马中春.2005.葡萄籽原花青素的安全性毒理学评价及抗突变作用研究.吉林大学硕士学位论文.
49.麦利.章达礼,徐焱,潘少鹏.2003.共轭亚油酸食品安全性毒理学试验研究.粮油食品科技,11(4):4-7.
50.孟宪军,刘学,周艳.2007.树莓叶片中精油的提取工艺.食品生物技术学报,26(3):6-9.
51.孟宪军.2006.食品工艺学概论.北京:中国农业出版社.
52.蒲育栋.2007.芹菜对雄性小鼠生殖系统影响的实验研究.兰州大学硕士学位论文.
53.倪郁,李加纳.2003.多不饱和脂肪酸研究及植物育种策略.中国油料作物学报,(2):100-103.
54.乔丽名,陈海生,梁爽,金丽.2006.青芹籽低极性部位化学成分GC-MS分析.解放军药学学报,22(2):101-103.
55.秦立虎,宗青山.2003.微胶囊技术及其在乳品加工业中的应用.山西食品工业,14(1):12-15.
56.孙爱东,葛毅强,倪元颖,阎红,蔡同一.1999.CO_2超临界流体萃取技术提取甜橙皮精油的研究.食品工业科技,20(3):7-8.
57.孙焕.2006.大豆分离蛋白复合改性及其在海豹油微胶囊中应用的研究.沈阳农业大学硕士学位论文.
58.孙庆杰,丁霄霖.1998.超临界流体萃取番茄籽油的研究.中国油脂,23(3):12-14.
59.王朝臣,阮美娟,王晓洁,于铁成.2007.柞蚕粉微胶囊化制备工艺的研究.农业工程学报,23(6):262-264.
60.王辰,张金木.2006.芹菜叶提取物抗氧化性的研究,安徽农业科学,34(13):3174-3175.
61.王发松,胡海燕,黄世亮等.2003.姜油的分子蒸馏纯化与化学成分分析.中国医药工业杂志,34(3):125-127.
62.王凤岩,谭剑斌,陈瑞仪,黄俊明.2005.深海鲨鱼月十油对小鼠耐缺氧能力、SOD活力及MDA含量的影响.毒理学杂志,(S1):330.
63.王金红,高尔.2001.乳化葛根素对高脂血症家兔模型调血脂和抗氧化作用.潍坊医学院学报,23(1);6.
64.王琳琳,凌文华,马静等.2002.黑米皮抑制高脂诱导家兔动脉粥样硬化形成及机制研究.营养学报,24(4):372-376.
65.王萍,赵清岩,王若菁等.1997.籽用南瓜种子脂肪和脂肪酸成分分析.内蒙古农业大学学报(自然科学版)6:42-45.
66.王顺民,郑丹,汤斌,孙建峰,周丽娟.2009.山核桃油中的脂肪酸GC法分析.中国调味品,(01):106-108,117.
67.王伟丽,刘学武,张晓冬,李志义.2002.超临界流体萃取技术及其在食品工业中的应用.食品研究与开发,23(1):4-6.
68.王小荣,邱明丰,谢国祥,张汉杰,贾伟.2006.当归油对痛经小鼠子宫组织中一氧化氮和钙离子的影响.时珍国医国药,17(5):723-724.
69.王燕,车振明.2005.食品防腐剂的研究进展.食品研究与开发,26(5):167-169.
70.王迎军,赵淑萍,郑翠兰.2003.芹菜治疗原发性高血压80例.中国民间疗法,7:57-58.
71.乌莉娅·沙衣提,耿萍,虞慧云.2007.维药芹菜籽总黄酮含量测定及提取工艺研究.时珍国医国药,(09):2102-2103.
72.吴彩娥.2001.超临界CO_2流体萃取技术提取核桃油的研究.农业工程学报,17(6):135-137.
73.吴东升,金磊.1997.食品工业中的喷雾干燥法微胶囊化.食品工业科技,(01):78-82.
74.吴克刚,余纲哲,柴向华.1998.油脂喷雾干燥微胶囊化的研究.食品科学,19(1):34-37.
75.吴鹏,张东明,张庆波.2000.短程燕馏原理及工业应用.化工进展,(1):49-52.
76.吴琼英,马海乐,李国文.2000.脂类及脂溶性物质的微胶囊技术.粮油加工食品机械,(5):4-6.
77.吴雪.2000.姜油树脂微胶囊化生产工艺的试验研究.中国农业大学硕士学位论文.
78.夏微,隋焕平,邱隽.2001.芹菜提取物对喂饲高脂饲料大鼠血.脂的影响.中国公共卫生,17(4):337-338.
79.夏向东,吕飞杰,台建祥.2001.生育三烯酚的研究进展.食品与发酵工业,(8):65-70.
80.肖西峰,金凡,谢丽,闵保华.2008.当归精油治疗痛经的机制研究.陕西医学杂志,37(2):141-143.
81.辛欣,范青生,罗眼科,王书满.2007.杜仲籽油可食用性研究.中国油脂,32(4):15-19.
82.熊华,郑为完.2002.粉末油质的特点与在食品工业中的应用.食品科学,23(5):154-157.
83.徐成.2001.芹菜籽油对脑衰老和脑缺血.的防治作用及机制探讨.沈阳药科大学硕士学位论文.
84.徐兴军,邵淑丽,吕建伟.2001.芹菜、绿豆、苦瓜对小白鼠高脂血症的影响.高师理科学刊,21(4):47-49.
85.许松林,应安国.2005.应用分子蒸馏技术提纯胡椒基丁醚.农业工程学报,21(2):169-171.
86.薛峰,黄晓青.1990.微胶囊技术主要方法概论.食品科学,13(11):5-8.
87.严建刚,张名位,杨公明等.2004.芹菜提取物清除自由基作用研究.食品科学,25(8):39-42.
88.严建刚,张名位,杨公明等.2005.芹菜黄酮的提取条件及其抗氧化活性研究.西北农林科技大学学报(自然科学版),33(1):131-135.
89.杨保收,陈越,龚伟,等.1999.氧自由基致损伤的分子生物学机制.中国兽医杂志,1(25):41-45.
90.扬桢.1999.超临界萃取洋葱油的研究.食品工业科技,20(3):9-10.
91.杨继红.2006.苹果籽油CO_2超临界萃取及微胶囊化研究.西北农林科技大学硕士学位论文.
92.杨君佑,杨浩,戴忠等.2004.芹菜水提物对心肌缺血再灌注损伤的保护作用.中国现代医学杂志,14(8):40-42.
93.杨晓泉,卞华伟.1999.食品毒理学.北京:中国轻工业出版社.
94.银建中,孙献文,原华山,丁信伟.2001.超临界CO_2流体萃取沙棘油实验研究.化学工业与工程技术,22(6):9-11
95.银建中,孙献文,李志义,丁信伟.2001.超临界CO_2流体萃取植物油的实验研究.现代化工,21(10):26-28.
96.应安国等.2005.分子蒸馏技术提纯胡椒基丁醚的工艺研究.化工进展,24(1):57-60.
97.于恩平,朱美文,方之蓉.1989.关于超临界萃取过程中使用夹带剂的研究.化学工程,1(4):21-24.
98.于海峰,王芳,孙玉洁,白红进.2008.刺山柑种子油中矿质元素含量的测定.塔里木大学学报,(04):26-29.
99.喻健良,翟志勇.2001.分子蒸馏技术的发展及研究现状闭.化学工程,29(5):70-75.
100.于守洋,崔鸿斌,石华主编.1996.中国营养保健食品指南.哈尔滨:黑龙江省科学出版社,134.
101.于澍人,高楠楠.1988a.芹菜甲素保护脑细胞的作用.药学学报,23(9):656-661.
102.于澍人,高楠楠.1988b.芹菜甲素增强学习记忆的作用.中国药理学报,9(5):385-388.
103.丁澍仁,尤胜权.1984a.芹菜甲素的药理作用.药学学报,19(7):484-490.
104.于澍仁,尤胜权.1984b.芹菜甲素和芹菜乙素的抗惊厥作用.药学学报,19(8):566-570.
105.余蜀宜,李建华,余蜀兴.1997.超临界技术在食品工业中的应用新进展.江苏食品与发酵,(3):28-32.
106.于志庚,陈卫军,王新春.2005.月红胶囊中经基红花黄色素A的HPLC定量分析.中国中药杂志,30(15):126-127.
107.原华山,银建中,丁信伟.2002.超临界CO_2萃取大豆油的实验研究.化学工业与工程技术,23(1):3-5.
108.苑林宏,吴坤.2004.芹菜素抗肿瘤作用的研究进展.中国公共卫生,20(2):241-242.
109.曾明华,沈咏舟,李琳等.蜂胶·蜂皇浆类冻干粉对小鼠的急性毒性试验.2005.安徽农业科学,33(1):120.
110.郑弢,许松林.2004.分子蒸馏提纯a-亚麻酸的研究.化学工业与工程,21(1):25-28.
111.郑宗林,黄朝芳.2001.ω-3型多不饱和脂肪酸对动物生产性能和免疫的作用.动物科学与动物医学,(06):51-53.
112.张德权,吕飞杰,台建祥.2001.超临界CO_2流体技术萃取姜油树脂的研究.食品工业科技,22(1):21.
113.张桂,畅天狮,刘俊果等.2002.芹菜中提取黄酮类物质的研究.食品科学,21(8):121-125.
114.张国栋,马力,唐僖,高毅.2005.分子包埋法制备姜油树脂微胶囊的研究.食品研究与开发,26(4):6-8.
115.张国宏,刘丽新,沈锋.1997.超临界二氧化碳萃取技术提取胡椒风味成分的研究.食品科学,18(11):21-24.
116.张捷莉,李铁醇,王君等.2004.两种不同芹菜籽油中脂肪酸的GC/MS分析.中国油脂,6:70-71.
117.张捷莉,王君,李铁纯等.2002.美国西芹菜籽挥发性成分的GC/MS分析.食品科学,23(8):225-227.
118.张捷莉,张胜彪,王君,李铁纯,侯东岩.2003.天津实心芹菜籽挥发性成分的GC/MS分析.鞍山示范学院学报,5(4):58-60.
119.张镜澄.2000超临界流体萃取.北京:化学工业出版社,7-9.
120.张丽英,冯亦璞,1996.丁基苯酞对脑卒中型自发性高血压大鼠寿命及卒中后神经症状的影响.药学学报,(01)18-23.
121.张秋霞.2007.薰衣草精油的提取、纯化及微胶囊化研究.石河子大学硕士学位论文.
122.张守尧,王鹏,张忠义,吴惠勤.2003.超临界CO_2萃取-分子蒸馏对当归的提取分离.解放军药学学报,19(5):375-377.
123.张燕萍,刘秋育.变性淀粉作微胶囊壁材研究初探.食品工业科技,(01):19-21.
124.张忠义,王鹏,雷正杰,吴惠勤.2003.超临界CO_2萃取-分子蒸馏对白术挥发油的提取分离和 GC/MS分析.分析测试学报,22(4):61-64.
125.章朝晖,冯巧嫦.2001.高纯度单脂肪酸甘油酷的制备.精细石油化工,3(2):18-22.
126.赵春顺.2003.3-正丁基苯酞体内药动学及脑内转运机理的研究.沈阳药科大学博士学位论文.
127.赵国志,陈燕,董剑林等.1997.油脂脱臭馏出物的回收和利用团中国油脂.22(2):51-53.
128.赵晓燕,冯作山,陈复生.2005.番茄红素微胶囊的稳定性研究.食品与发酵工业,31(10):45-48.
129.赵亚平,胡成一,林茂福等.1996.超临界CO_2流体萃取辣椒精细成分的研究(Ⅰ)--从干辣椒中提取辣椒色素.食品工业科技.(4):15-18.
130.赵妍嫣,姜绍通,唐文婷,邵平.2004.菜籽油脱臭馏出物中维生素E萃取分离的研究.食品科学,(12):132-135.
131.中华人民共和国国家标准.2003.食品安全性毒理学评价程序和方法,19-58,85-94.
132.中医大辞典.1985.江苏新医学院.上海科技出版社,286-287.
133.钟耕.魏益民,史吕欧.2006.含二十八烷醇油胶囊安全性毒理学评价.食品与生物技术学报,25(4):11-15.
134.钟耕,吴永娴,曾儿坤.1995.从甜橙油中提取类胡萝卜素工艺及其性质研究.四川日化,(3):6-9.
135.钟敬波,徐成,丁倩,曹颖林.2008.芹菜籽油抗D-半乳糖致衰老模型动物的作用研究.中国药房,(24):55.
136.朱倚.1987.生物化学实验.上海:上海科学技术出版社.
137.朱选,汪洋.1999.微胶囊技术及其在食品工业中的应用.粮食与饲料工业,(11):47-49.
138.朱迅涛,许时婴.1998.以大豆蛋白制备微胶囊化鱼油的研究(Ⅰ)—微胶囊化鱼油的壁材选择.中国油脂,(05):31-34.
139.朱迅涛,许时婴.1998.以大豆蛋白制备微胶囊化鱼油的研究(Ⅱ)—微胶囊化鱼油的工艺研究.中国油脂,(06):35-382.
140.朱自强,2000,超临界流体技术—原理和应用.北京:化学工业出版社
141.邹丹,刘维春.2001.中华大蒜油对家兔实验性高脂血症的防治作用.河南医学研究,10(1):20-21.
142.Molero Gomez,et al.1996.Recovery of grape seed oil by liquid and supercritical carbon dioxide extraction a comparison with conventional solvent extraction.The Chemical Engineering Journal,61:227-231.
143.Arterburn L M,Boswell K D,Koskelo E K,et al.2000.A combined subchronic(90-day)toxicity and neurotoxicity:study of a single-cell source of docosahexaenoic acid triglyceride(DHASCOoil).Food and Chemical Toxicology,38:35-49.
144.Shoetan,Augusti K T,Joseph P K.1984.Hypolipidemic effects of garlic oil in rats fed ethanol and a high lipid-diet.Cellular and Molecular Life Sciences,40(3):261-263.
145.Sipailiene,Venskutonis P R,Sarkinas A,et al.1993.Composition and antimicrobial activity of celery(Apium graveolens)leaf and root extracts obtained with liquid carbon dioxide.http://www.actahort.org/books/677/677-9.
146.Ahn J H,Kim Y P.Lee Y M,et al.2008.Optimization of microencapsulation of seed oil by response surface methodology.Food Chemistry,107(1):98-105.
147.Ahn J H,Kim Y P,Seo E M,et al.2008.Antioxidant effect of natural plant extracts on the microencapsulated high oleic sunflower oil.Journal of Food Engineering,84(2):327-334.
148.Anonymous.Residues of some veterinary drugs in animals and food[z].FAO Food and Nutrition Paper 41/3,19-30,53-62,85-96.
149.Batistella C B,Moraes E B,Maciel Filho R,et al.2002.Moleclar distillation process for recovering biodiesel and carotenoids from palm oil.Applied Biochemistry and Biotechnology,(Spring):1149-1159.
150.Bjieldanes L F,el al.1978.Sedative activity of celery oil constituents.J Food Sci,43:143.
151.Buck,Griffith J.1979.Carefree Beauty Rose.Hort Science,14(2):196-197.
152.Batistella C B,Wolf Maciel M R.1998.Recovery of carotenoids from palm oil by molecular distillation.Computers and Chemical Engineering,22:53-60.
153.Chang Q,Wang X L.2003.Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats.Acta Pharmacol Sin,24(8):796.
154.Chen Y T,et al.1990.Flavonoids as superoxide scavengers and antioxidants.Free Rad Biol Med,9:19-21.
155.Choochote W,Tuetun B,Kanjanapothi D,et al.2004.Potential of crude seed extract ofcelety,Apium graveolens L,against the mosquito Aedes aegypti(L)(Diptera:Culicidae).J Vector Ecol,29(2):340-6.
156.Dahlin M Bergman U,Jansson B,Bjork E,Britebo E.2000.Transfer of dopamine in theolfactory pathway following nasal administration in mice.Pharm Res,17:737-742.
157.De Almeida R N.2004.Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze testin rats.Pharmacology,Biochemistry and Behavior,77(2):361-364.
158.Dionisi F,Hug B,Aeschlimann J M.1999.Supercritical CO_2 extraction for total fat analysis of food products.Journal of Food Science,64(4):612-615.
159.Durak I,Karaayvaz M,Cimen M Y,et al.2001.Aspirin impairs antioxidant system and causes peroxidation in human erythrocytes and guinea pig myocardial tissue.HumExp Toxico,20(1):34-37.
160.Reverchon E,et al.1995.Supercritical CO_2 Extraction and Fractionation of Lavender Essential Oil and Waxes.J Agric Food Chem,43:1654-1658.
161.Siah l E,Schutz E and Mangold K.1980.Extraction of seed oils with liquid and supercritical carbon dioxide.J.Agric.Food Chem,28:1153-1157.
162.Fabre,Cathy E,Marty.1999.Extractive fermentation of aroma with supercritical CO_2.Biotechnology and Bioengineering,64(4):392-400.
163.Favatai F.1991.Supercritical carbon dioxide extraction of evening primrose oil.JAOCS,68(6):422-427.
164.Fereidoon S,X.Q.Han.1993.Encapsulation of Food Ingredients.CRC Reviews in Food Sci and Nutri,33(6):501-547.
165.Food and Agreculture Organization of the Unition Nations.1991.Residues of some veterinary drugs in animals and foods.FAO Food and Nutrition Paper,41(3):85-96.
166.Fozia Anjum,Farooq Anwar,Amer Jamil,M.Iqbal.2006.Microwave roasting effects on the physico-chemical composition and oxidative stability of sunflower seed oil.Journal of the American Oil Chemists'Society,83(9):777-784.
167.Guo C J,Yang J J,Wei JY,et al.2003.Antioxidant activities of peel,pulp and seed fractions of common fruits as determined by FRAP assay.Nutr Res,23:1719.
168.Hogan SA,Mcnamee BF.2001.Microencapsulating properties of whey protein concentrate 75.Journal of Food Science,66(5):675-680.
169.Papamichail;V.Louli;K.Magoulas.2000.Supercritical fluid extraction of celery seed oil.The Journal of Supercritical Fluids,18(3):213-226.
170.In Hwan Kim,Suk Hoo Yoon.1990.Effect of extraction solvents on oxidative stability of crude soybean oil.Journal of the American Oil Chemists'Society,67(3):165-167.
171.Jakovljevic V,Raskovic A,Popovic M,et al.2002.The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism.Eur J Drug Metab Pharmacokinet,27(3):153-6.
172.Jan Cvengios,et al.2000.Modelling of fraction in a molecular evaporator with divided condenser.J Chen Eng,39:191.
173.Jerry W K,James HJ,John PF.1989.Extraction of Fat Tissue from Meat Products With Supercritical Carbon Dioxide.J Agric Food Chem,37:951-954.
174.John P.Friedrich et al.1982.Characterization of soybean oil extracted by supercritical CO_2 and hexane.J.Agric Food Chem,30:192-193.
175.Judie D.Dziezak.1988.Microdencapsulation and encapsulated ingredients.Food Technology,25(4)::136-149.
176.Juraj.Lutisan Miroslaw Micro,Jan Cvengros.1998.The influence of entrainment separator on the process of molecular distillation.Separation Science and Technology,33(1):83.
177.Kayamori F,lgarashi K.1994.Effects of dietary nasunio on the serum cholesterol level in rats.Biosci Biotechnol.Biochem,58:507-571.
178.Kjeld Hermansen,Bo Dinesen,LarsH.Hoie,Eve Morgenstern,Joerg G ruenwald.2003.Effects of soy and other natural products on LDL:HDL ratio and other lipid parameters:A literature review.Advances in:Therapy,20(1):50-78.
179,Ko FN,Huang TF,Teng CM.1991.Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rt thoracic aorta.Biophys Acta,1115(1):69-74.
180.L Cinquanra,M Esti,M Matteo.2001.Oxidative stability of virgin olive oils.Journal of the American Oil Chemists'Society,78(12):1197-1202.
181.Lin LZ,LuS,Harnly JM.2007.Detection and quantification of glycosylated flavonoid malonates in celery,Chinese celery,and celery seed by LC-DAD-ESI/MS.Journal of Agricultural and Food Chemistry,55(4):1321-1326.
182.M.A.Trindade,C.R.F.Grosso.2000.The stability of ascorbic acid microencapsulated in granules of rice starch and in gum Arabic.Journal Microencapsulation,17(2):169-176.
183.Macdonald H,Bedwell B,Gulari E.1986,FTIR spectroscopy of microemulsion structure.Langmuir,2(6):704-708.
184.M.M.Saleh,J.H.Zwaving,Th.M.Malingr6,R.Bos.1985.The essential oil of Apium graveolens vat.secalinum and its cercaricidal activity.Pharmaceutisch Weekblad Scientific Edition,7(6):277-279.
185.M.Z.Ozel,A.A.Clifford.2004.Superheated water extraction of fragrance cornpounds from Rosa canina.Flavour and Fragrance Journal,19(4):354-359.
186.Momin RA,Nair M G.2001.Mosquito cidal nematicidal,and antifungal compounds from Apium graveolens L.seeds.J Agric Food Chem,49(1):142-5.
187.Momin RA,Nair MG.2002.Antioxidant cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn.seeds.Phytomedicine,9(4):312-8.
188.Momin RA,Ramsewak RS,Nair MG.2000.Bioactive compounds and 1,3-Di[(cis)-9-o ctadecenoyl]-2-[(cis,cis)-9,12-o ctadecadienoyl]glycerol from Apium graveolen L.seeds[J].J Agric Food Chem,48(9):3785-8.
189.Moreau DL,Rosenberg M.1996.Oxidative stability of anhydrous milkfat microencapsulated in whey proteins.Food Sci,61(1):39.
190.Mukul Das,KaushalK.Upreti,SubhashK.Khanna.1991.Biochemical toxicology of argemone oil.Role of reactive oxygen species in iron catalyzed lipid peroxidation,46(3):422-430.
191.Nikita Sihag,Asha Kawatra.2003.Hypolipidemic effect of pulse seed coats in rats.Plant Foods for Human Nutrition.58(3):1-1 0.
192.Nurhayat Tabanca,Betul Demirci,Temel Ozek,Nese Kirimer,K.Husnu Can Baser,Erdal Bedir,Ikhlas.Khand,eDavid E.Wedge.2006.Gas chromatographic-mass spectrometric analysis of essential oils from Pimpinella species gathered from Central and Northern Turkey.Journal of Chromatography A,1117:194-205.
193.Pal E.Ho N,Santos C,et al.2003.Red wine polyphenolics Increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human hepG2 cells.J Nutr,133:700.
194.Palmer M.V,Ting.1995.Applications for Supercriticalfluid Technology in Food Processing.Food Chemistry,52:345-352.
195.Papamichail I,Loull V,Mlagoulas K.2000.Supercritical fluid extraction of celery seed oil.The Journal of Suoercritical Fluids,18(3):213-226
196.Pauleti MS,Mestoy P.1999.Butter m icroencapsulation as affected by composition of wall material and fat.J.Food Sci,64(2):279
197.Popovid M,Kaurinovid B,Trivid S,Mimica—Dukid N,Bursa6 M.2006.Effect of celery(Apium graveolens)extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride.Phytother Res,20(7):531-537.
198.Reorge AS,Hao C,Steven JS.1993.Supercritical CO_2 extraction of 13-carotene from sweet potatoes.Food Sci,58(4):817-820.
199.Rezvukin,Berezovikova,Shalaurova,Nikitin.Fatty acid composition of alfalfa seed oil.Chemistry of Natural Compounds,1996,31(4):518.
200.Rincon J,Garcia I,De Lucas.2000.Isolation of rock rose essential oil using supercritical CO_2extraction.Separation Science and Technology,35(16):2745-2763.
201.Roshanai F.1985.Sanders TAB:Influence of different supplements of n-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid.Ann Nutr Metab,29:189.
202.Sovova H,et al.1994.Rate of the vegetable oil extraction with supercritical CO_2 Extraction of grape oil.Chemical Engineering Science,49(3):415-420.
203.S.Sudheesh,G.Presannakumar,S.Vijayakumar,N.R.Vijayalakshmi.1997.Hypolipidemic effect of flavonoids from Solanum melongena.Plant Foods for Human Nutrition,51(4):321-330.
204.Stratton SP,Dorr RT,Alberts DS,et al.2000.The state-of-the-art in chemoprevention of skin cancer.Eur,I Cancer.36(10):1292-1297.
20.5:Szentmihalvi K,Vinkler P,Lakatos B.2002.Rose hip oil obtained from waste hip seeds by different extraction methods Bioresource Technology,82(2):195-201.
206.TammyD Crowe,PamelaJ White.2003.Oxidative stability of walnut oils extracted with supercritical carbon dioxide.Journal of the American Oil Chemists'Society,80(6):575-578.
207.Tong Wang.Yongzhi Jiang,EarlG Hammond.2005.Effect of randomization on the oxidative stability of corn oil.Journal of the American Oil Chemists'Society,82(2):111-117.
208.Tsi D,Das NP,Tan BK.1995.Effects of aqueous celery(Apium graveolens)extract on lipid parameters os rats fed a high fat diet.Planta Med,61(1):18-21.
209.Tsi D,Tan BK.1996:Effects of celery extract and 3-N-butylphthalide on lipid level in gentically hypercholesterolaemic(RICO)rats.Clin Exp Pharmacol Physiol,23(3):214-7.
210.Wei A,Shibamoto T.2007.Antioxidant activities and volatile constituents of various essential oils.Journal of Agricultural and Food Chemistry,55(5):1737-1742.
211.Witschi H,Uyeminami D,Moran D,et al.2000.Chemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposure.Carcinogenesis,21(5):977-982.
212.Witulski B.;Zimmermann A.2002.Synthesis of chiral 3-substituted phthalides via rhodium (1)-catalyzed crossed alkyne cyclotrimerisation.Synlett,(11):1855-1859.
213.Wojciech Kolanowski,Maciej Ziolkowski,Jenny Weiβbrodt.Benno Kunz,G(u|¨)nther Laufenberg.2005.Microencapsulation of fish oil by spray drying--impact on oxidative stability.European Food Research and Technology,222(3):336-342.
214.Yah CH,Fen YP.1998.Effect ofdl-3-n-butylphthalid on striatum cerebral blood flow in normal and middle cerebral artery occlusion rats.Acta Pharmacol Sin,12(1):36-39.
215.Zhang H Y,Chen D Z.2000.Theoretical elucidation on activity differences of ten flavonoid antioxidants.Acta Biochimica Sinica,32(4):317-321.
216.Zheng GQ,Kenney PM,Zhang J,et al.1993.Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil.Nutr Cancer,19(1):77-86.
2.毕丽君,李慧.1999.水芹中黄酮类化合物最佳提取工艺的研究.食品科学,12:35-37.
3.毕艳红.2007.分子蒸馏技术分离提纯大蒜精油的研究.山东农业大学硕士学位论文.
4.臣战国,张怀涛,李伟.2008.芹菜籽精油成分以及清除亚硝酸作用.化学与粘合,30(6):38-40.
5.程志清,吴惠勤,张桂英.1989.GC/MS法快速测定食用植物油中脂肪酸含量.分析测试学报,8(16):11-14.
6.董高翔,冯亦璞.1999.丁基苯酞及其光学异构体的抗惊厥作用.中国药理学通报,(01):92-93.
7.董高翔,冯亦璞.2002.丁基苯酞对局部脑缺血再灌注大鼠脑线粒体ATPase,抗氧化酶活性和脂质过氧化的影响.中国医学科学院学报,(01):93-97.
8.董丽花,范增民.2004.不同品种芹菜不同部位微量元素含量研究.微量元素与健康研究,6:70-71.
9.范培军,郭振德,张镜澄等.1995.芹菜籽的超临界CO_2流体萃取物的化学成分研究.天然产物研究与开发,(6):89-92.
10.范伟忠,章荣华.2002.薏苡仁油的毒性研究及安全性评价.上海医学预防杂志,12(4):178-179.
11.方景岩,于才渊,姚辉,朱琳.2005.喷雾干燥制备番茄红素微胶囊.干燥技术与设备,3(1):19-23.
12.方允中,郑荣梁.2002.自由基生物学的理论与应用.北京:科学出版社,60-69.
13.冯卫华.2003.猕猴桃籽油微胶囊化技术研究.西北农林科技大学硕士学位论文.
14.冯武文,杨村.2002.分子蒸馏技术在日化工业中的应用及前景.日用化学工业,6:73-75.
15.傅红,裘爱咏.2002.分子蒸馏法制备鱼油多不饱和脂肪酸田.无锡轻工大学学报,21(6):617-621.
16.高尔,王金红.2001.乳化葛根素对高脂血症家兔血清NO及PC量的影响.潍坊医学院学报,23(1);1-3.
17.高金燕,陈红兵.2005.芹菜籽中活性成分研究进展.中国食物与营养,7:28-31.
18.高金燕,曾小花,王毅辉等.2004.从芹菜中提取黄酮类物质的初步研究.中国食品添加剂,3:19-21.
19.顾冬雨,吕金良,古丽娜·沙比尔,阿吉艾克拜尔·艾萨.2007.高效液相色谱法测定芹菜籽中3-正丁基苯酞的含量.时珍国医国药,18(3):513-514.
20.顾刘金,杨校华,陈琼姜等.2004.SD大鼠脏器正常参考值探讨.浙江省医学科学院学报,57(6):25-27.
21.郭红,陈在嘉,徐义枢.1991.血清脂质与脂质过氧化关系的临床研究.中国循环杂志,6(5):373-375.
22.郭蕾,陈彤,陈哓岚等.2003.芹菜籽挥发油化学成分的研究.河南科学,21(6):728-729.
23.郭美丽,周燕平,何海健等.2008.杜仲籽油毒理学安全性评价.毒理学杂志,22(3):248-249.
24.郭燕.1999.超临界流体萃取的原理和应用.湖北人民出版社.
25.何耀,李良涛,万志恒.1990.冠心病血清载脂蛋白A1和B100的观察.中华心血管病杂志,18(4):217-219.
26.胡庆国.2003.超临界CO_2萃取芹菜籽油的工艺研究.食品研究与开发,24(2):30-31.
27.贾海伦.2008.芹菜黄酮提取及分离纯化工艺研究.黑龙江大学硕士学位论文.
28.李爱民,王玉兰,赵淑兰,赵景辉,王玉方.1997.儿种野生芹菜营养成分分析.特产研究,(03):18-19.
29.李全宏,倪元颖.2002超临界CO_2流体萃取南瓜籽油的质量研究.食品工业科技,23(4):22-25.
30.李雪梅,周谨,张晓龙,杨叶昆,邓国宾.2004.超临界CO_2流体萃取与常规提取方法制备芹菜籽精油的比较.精细化工,21(8):581-585.
31.李艳.2006.核桃油的提取及微胶囊化制备技术的研究.中国农业大学硕士学位论文.
32.李延辉.2005.微胶囊化榛仁油的制备技术及工艺研究.吉林农业大学硕士学位论文.
33.李毅敏,周连发,王士贤.2004.复方益母草膏治疗痛经药理机制的实验研究.中成药,26(4):311-314.
34.李岳.2004.新疆芹菜籽和苦豆子活性成分的药效学、毒理学实验及苦豆子降血脂分子生物学机制研究.中国科学院新疆理化技术研究所硕士学位论文.
35.林红秀,伍培辉,柯于家.1999.超临界CO_2萃取玉米黄色素的研究.郑州粮食学院学报.20(3):57-60.
36.刘冬文.2003.大蒜油的提取及微胶囊化研究.中国农业大学硕士学位论文.
37.刘峰林,王瑞琼,马中山等.2006.当归油治疗痛经的药效学实验研究.现代中药研究与实践,20(6):22-23.
38.刘洛生,娄红祥.任健,郭启雷.2001.安清益智胶囊的质量标准研究.山东医科大学学报,39(6):562-564.
39.刘小光,冯亦璞.1995.丁基苯酞对局部脑缺血大鼠行为和病理改变的保护作用.药学学报,30(10):896-902.
40.刘咏松.2004.芹菜的本草研究及功用.四川中医,22(7):25-26.
41.陆韩涛,程玉镜.1993.芳香油的分子蒸馏提纯.精细化工,10:44-46.
42.陆生椿.汪清泉,郭傅衍.1995.超临界CO_2流体萃取芹菜籽香料的应用技术研究.四川日化,(1):1-3.
43.陆战国.张怀涛,苏荣军.2008.芹菜籽香气成分分析.化学研究,19(2):58-64.
44.吕金良,牟新利,王武宝等.2006.维药芹菜籽化学成分研究.时珍国医国药,17(1):6-7.
45.马海乐.2001a.超临界CO_2萃取技术及其在生物资源开发利用中应用的最新进展(Ⅰ).包装与食品机械.19(20):1-5.
46.马海乐.2001b.超临界CO_2萃取技术及其在生物资源开发利用中应用的最新进展(Ⅱ).包装与食品机械.19(3):7-10,17.
47.马传国,王兴国,张根旺等.2001.分予燕馏对高酸值花椒籽油脱酸的初步探讨.中国油脂,26(3):50-52.
48.马中春.2005.葡萄籽原花青素的安全性毒理学评价及抗突变作用研究.吉林大学硕士学位论文.
49.麦利.章达礼,徐焱,潘少鹏.2003.共轭亚油酸食品安全性毒理学试验研究.粮油食品科技,11(4):4-7.
50.孟宪军,刘学,周艳.2007.树莓叶片中精油的提取工艺.食品生物技术学报,26(3):6-9.
51.孟宪军.2006.食品工艺学概论.北京:中国农业出版社.
52.蒲育栋.2007.芹菜对雄性小鼠生殖系统影响的实验研究.兰州大学硕士学位论文.
53.倪郁,李加纳.2003.多不饱和脂肪酸研究及植物育种策略.中国油料作物学报,(2):100-103.
54.乔丽名,陈海生,梁爽,金丽.2006.青芹籽低极性部位化学成分GC-MS分析.解放军药学学报,22(2):101-103.
55.秦立虎,宗青山.2003.微胶囊技术及其在乳品加工业中的应用.山西食品工业,14(1):12-15.
56.孙爱东,葛毅强,倪元颖,阎红,蔡同一.1999.CO_2超临界流体萃取技术提取甜橙皮精油的研究.食品工业科技,20(3):7-8.
57.孙焕.2006.大豆分离蛋白复合改性及其在海豹油微胶囊中应用的研究.沈阳农业大学硕士学位论文.
58.孙庆杰,丁霄霖.1998.超临界流体萃取番茄籽油的研究.中国油脂,23(3):12-14.
59.王朝臣,阮美娟,王晓洁,于铁成.2007.柞蚕粉微胶囊化制备工艺的研究.农业工程学报,23(6):262-264.
60.王辰,张金木.2006.芹菜叶提取物抗氧化性的研究,安徽农业科学,34(13):3174-3175.
61.王发松,胡海燕,黄世亮等.2003.姜油的分子蒸馏纯化与化学成分分析.中国医药工业杂志,34(3):125-127.
62.王凤岩,谭剑斌,陈瑞仪,黄俊明.2005.深海鲨鱼月十油对小鼠耐缺氧能力、SOD活力及MDA含量的影响.毒理学杂志,(S1):330.
63.王金红,高尔.2001.乳化葛根素对高脂血症家兔模型调血脂和抗氧化作用.潍坊医学院学报,23(1);6.
64.王琳琳,凌文华,马静等.2002.黑米皮抑制高脂诱导家兔动脉粥样硬化形成及机制研究.营养学报,24(4):372-376.
65.王萍,赵清岩,王若菁等.1997.籽用南瓜种子脂肪和脂肪酸成分分析.内蒙古农业大学学报(自然科学版)6:42-45.
66.王顺民,郑丹,汤斌,孙建峰,周丽娟.2009.山核桃油中的脂肪酸GC法分析.中国调味品,(01):106-108,117.
67.王伟丽,刘学武,张晓冬,李志义.2002.超临界流体萃取技术及其在食品工业中的应用.食品研究与开发,23(1):4-6.
68.王小荣,邱明丰,谢国祥,张汉杰,贾伟.2006.当归油对痛经小鼠子宫组织中一氧化氮和钙离子的影响.时珍国医国药,17(5):723-724.
69.王燕,车振明.2005.食品防腐剂的研究进展.食品研究与开发,26(5):167-169.
70.王迎军,赵淑萍,郑翠兰.2003.芹菜治疗原发性高血压80例.中国民间疗法,7:57-58.
71.乌莉娅·沙衣提,耿萍,虞慧云.2007.维药芹菜籽总黄酮含量测定及提取工艺研究.时珍国医国药,(09):2102-2103.
72.吴彩娥.2001.超临界CO_2流体萃取技术提取核桃油的研究.农业工程学报,17(6):135-137.
73.吴东升,金磊.1997.食品工业中的喷雾干燥法微胶囊化.食品工业科技,(01):78-82.
74.吴克刚,余纲哲,柴向华.1998.油脂喷雾干燥微胶囊化的研究.食品科学,19(1):34-37.
75.吴鹏,张东明,张庆波.2000.短程燕馏原理及工业应用.化工进展,(1):49-52.
76.吴琼英,马海乐,李国文.2000.脂类及脂溶性物质的微胶囊技术.粮油加工食品机械,(5):4-6.
77.吴雪.2000.姜油树脂微胶囊化生产工艺的试验研究.中国农业大学硕士学位论文.
78.夏微,隋焕平,邱隽.2001.芹菜提取物对喂饲高脂饲料大鼠血.脂的影响.中国公共卫生,17(4):337-338.
79.夏向东,吕飞杰,台建祥.2001.生育三烯酚的研究进展.食品与发酵工业,(8):65-70.
80.肖西峰,金凡,谢丽,闵保华.2008.当归精油治疗痛经的机制研究.陕西医学杂志,37(2):141-143.
81.辛欣,范青生,罗眼科,王书满.2007.杜仲籽油可食用性研究.中国油脂,32(4):15-19.
82.熊华,郑为完.2002.粉末油质的特点与在食品工业中的应用.食品科学,23(5):154-157.
83.徐成.2001.芹菜籽油对脑衰老和脑缺血.的防治作用及机制探讨.沈阳药科大学硕士学位论文.
84.徐兴军,邵淑丽,吕建伟.2001.芹菜、绿豆、苦瓜对小白鼠高脂血症的影响.高师理科学刊,21(4):47-49.
85.许松林,应安国.2005.应用分子蒸馏技术提纯胡椒基丁醚.农业工程学报,21(2):169-171.
86.薛峰,黄晓青.1990.微胶囊技术主要方法概论.食品科学,13(11):5-8.
87.严建刚,张名位,杨公明等.2004.芹菜提取物清除自由基作用研究.食品科学,25(8):39-42.
88.严建刚,张名位,杨公明等.2005.芹菜黄酮的提取条件及其抗氧化活性研究.西北农林科技大学学报(自然科学版),33(1):131-135.
89.杨保收,陈越,龚伟,等.1999.氧自由基致损伤的分子生物学机制.中国兽医杂志,1(25):41-45.
90.扬桢.1999.超临界萃取洋葱油的研究.食品工业科技,20(3):9-10.
91.杨继红.2006.苹果籽油CO_2超临界萃取及微胶囊化研究.西北农林科技大学硕士学位论文.
92.杨君佑,杨浩,戴忠等.2004.芹菜水提物对心肌缺血再灌注损伤的保护作用.中国现代医学杂志,14(8):40-42.
93.杨晓泉,卞华伟.1999.食品毒理学.北京:中国轻工业出版社.
94.银建中,孙献文,原华山,丁信伟.2001.超临界CO_2流体萃取沙棘油实验研究.化学工业与工程技术,22(6):9-11
95.银建中,孙献文,李志义,丁信伟.2001.超临界CO_2流体萃取植物油的实验研究.现代化工,21(10):26-28.
96.应安国等.2005.分子蒸馏技术提纯胡椒基丁醚的工艺研究.化工进展,24(1):57-60.
97.于恩平,朱美文,方之蓉.1989.关于超临界萃取过程中使用夹带剂的研究.化学工程,1(4):21-24.
98.于海峰,王芳,孙玉洁,白红进.2008.刺山柑种子油中矿质元素含量的测定.塔里木大学学报,(04):26-29.
99.喻健良,翟志勇.2001.分子蒸馏技术的发展及研究现状闭.化学工程,29(5):70-75.
100.于守洋,崔鸿斌,石华主编.1996.中国营养保健食品指南.哈尔滨:黑龙江省科学出版社,134.
101.于澍人,高楠楠.1988a.芹菜甲素保护脑细胞的作用.药学学报,23(9):656-661.
102.于澍人,高楠楠.1988b.芹菜甲素增强学习记忆的作用.中国药理学报,9(5):385-388.
103.丁澍仁,尤胜权.1984a.芹菜甲素的药理作用.药学学报,19(7):484-490.
104.于澍仁,尤胜权.1984b.芹菜甲素和芹菜乙素的抗惊厥作用.药学学报,19(8):566-570.
105.余蜀宜,李建华,余蜀兴.1997.超临界技术在食品工业中的应用新进展.江苏食品与发酵,(3):28-32.
106.于志庚,陈卫军,王新春.2005.月红胶囊中经基红花黄色素A的HPLC定量分析.中国中药杂志,30(15):126-127.
107.原华山,银建中,丁信伟.2002.超临界CO_2萃取大豆油的实验研究.化学工业与工程技术,23(1):3-5.
108.苑林宏,吴坤.2004.芹菜素抗肿瘤作用的研究进展.中国公共卫生,20(2):241-242.
109.曾明华,沈咏舟,李琳等.蜂胶·蜂皇浆类冻干粉对小鼠的急性毒性试验.2005.安徽农业科学,33(1):120.
110.郑弢,许松林.2004.分子蒸馏提纯a-亚麻酸的研究.化学工业与工程,21(1):25-28.
111.郑宗林,黄朝芳.2001.ω-3型多不饱和脂肪酸对动物生产性能和免疫的作用.动物科学与动物医学,(06):51-53.
112.张德权,吕飞杰,台建祥.2001.超临界CO_2流体技术萃取姜油树脂的研究.食品工业科技,22(1):21.
113.张桂,畅天狮,刘俊果等.2002.芹菜中提取黄酮类物质的研究.食品科学,21(8):121-125.
114.张国栋,马力,唐僖,高毅.2005.分子包埋法制备姜油树脂微胶囊的研究.食品研究与开发,26(4):6-8.
115.张国宏,刘丽新,沈锋.1997.超临界二氧化碳萃取技术提取胡椒风味成分的研究.食品科学,18(11):21-24.
116.张捷莉,李铁醇,王君等.2004.两种不同芹菜籽油中脂肪酸的GC/MS分析.中国油脂,6:70-71.
117.张捷莉,王君,李铁纯等.2002.美国西芹菜籽挥发性成分的GC/MS分析.食品科学,23(8):225-227.
118.张捷莉,张胜彪,王君,李铁纯,侯东岩.2003.天津实心芹菜籽挥发性成分的GC/MS分析.鞍山示范学院学报,5(4):58-60.
119.张镜澄.2000超临界流体萃取.北京:化学工业出版社,7-9.
120.张丽英,冯亦璞,1996.丁基苯酞对脑卒中型自发性高血压大鼠寿命及卒中后神经症状的影响.药学学报,(01)18-23.
121.张秋霞.2007.薰衣草精油的提取、纯化及微胶囊化研究.石河子大学硕士学位论文.
122.张守尧,王鹏,张忠义,吴惠勤.2003.超临界CO_2萃取-分子蒸馏对当归的提取分离.解放军药学学报,19(5):375-377.
123.张燕萍,刘秋育.变性淀粉作微胶囊壁材研究初探.食品工业科技,(01):19-21.
124.张忠义,王鹏,雷正杰,吴惠勤.2003.超临界CO_2萃取-分子蒸馏对白术挥发油的提取分离和 GC/MS分析.分析测试学报,22(4):61-64.
125.章朝晖,冯巧嫦.2001.高纯度单脂肪酸甘油酷的制备.精细石油化工,3(2):18-22.
126.赵春顺.2003.3-正丁基苯酞体内药动学及脑内转运机理的研究.沈阳药科大学博士学位论文.
127.赵国志,陈燕,董剑林等.1997.油脂脱臭馏出物的回收和利用团中国油脂.22(2):51-53.
128.赵晓燕,冯作山,陈复生.2005.番茄红素微胶囊的稳定性研究.食品与发酵工业,31(10):45-48.
129.赵亚平,胡成一,林茂福等.1996.超临界CO_2流体萃取辣椒精细成分的研究(Ⅰ)--从干辣椒中提取辣椒色素.食品工业科技.(4):15-18.
130.赵妍嫣,姜绍通,唐文婷,邵平.2004.菜籽油脱臭馏出物中维生素E萃取分离的研究.食品科学,(12):132-135.
131.中华人民共和国国家标准.2003.食品安全性毒理学评价程序和方法,19-58,85-94.
132.中医大辞典.1985.江苏新医学院.上海科技出版社,286-287.
133.钟耕.魏益民,史吕欧.2006.含二十八烷醇油胶囊安全性毒理学评价.食品与生物技术学报,25(4):11-15.
134.钟耕,吴永娴,曾儿坤.1995.从甜橙油中提取类胡萝卜素工艺及其性质研究.四川日化,(3):6-9.
135.钟敬波,徐成,丁倩,曹颖林.2008.芹菜籽油抗D-半乳糖致衰老模型动物的作用研究.中国药房,(24):55.
136.朱倚.1987.生物化学实验.上海:上海科学技术出版社.
137.朱选,汪洋.1999.微胶囊技术及其在食品工业中的应用.粮食与饲料工业,(11):47-49.
138.朱迅涛,许时婴.1998.以大豆蛋白制备微胶囊化鱼油的研究(Ⅰ)—微胶囊化鱼油的壁材选择.中国油脂,(05):31-34.
139.朱迅涛,许时婴.1998.以大豆蛋白制备微胶囊化鱼油的研究(Ⅱ)—微胶囊化鱼油的工艺研究.中国油脂,(06):35-382.
140.朱自强,2000,超临界流体技术—原理和应用.北京:化学工业出版社
141.邹丹,刘维春.2001.中华大蒜油对家兔实验性高脂血症的防治作用.河南医学研究,10(1):20-21.
142.Molero Gomez,et al.1996.Recovery of grape seed oil by liquid and supercritical carbon dioxide extraction a comparison with conventional solvent extraction.The Chemical Engineering Journal,61:227-231.
143.Arterburn L M,Boswell K D,Koskelo E K,et al.2000.A combined subchronic(90-day)toxicity and neurotoxicity:study of a single-cell source of docosahexaenoic acid triglyceride(DHASCOoil).Food and Chemical Toxicology,38:35-49.
144.Shoetan,Augusti K T,Joseph P K.1984.Hypolipidemic effects of garlic oil in rats fed ethanol and a high lipid-diet.Cellular and Molecular Life Sciences,40(3):261-263.
145.Sipailiene,Venskutonis P R,Sarkinas A,et al.1993.Composition and antimicrobial activity of celery(Apium graveolens)leaf and root extracts obtained with liquid carbon dioxide.http://www.actahort.org/books/677/677-9.
146.Ahn J H,Kim Y P.Lee Y M,et al.2008.Optimization of microencapsulation of seed oil by response surface methodology.Food Chemistry,107(1):98-105.
147.Ahn J H,Kim Y P,Seo E M,et al.2008.Antioxidant effect of natural plant extracts on the microencapsulated high oleic sunflower oil.Journal of Food Engineering,84(2):327-334.
148.Anonymous.Residues of some veterinary drugs in animals and food[z].FAO Food and Nutrition Paper 41/3,19-30,53-62,85-96.
149.Batistella C B,Moraes E B,Maciel Filho R,et al.2002.Moleclar distillation process for recovering biodiesel and carotenoids from palm oil.Applied Biochemistry and Biotechnology,(Spring):1149-1159.
150.Bjieldanes L F,el al.1978.Sedative activity of celery oil constituents.J Food Sci,43:143.
151.Buck,Griffith J.1979.Carefree Beauty Rose.Hort Science,14(2):196-197.
152.Batistella C B,Wolf Maciel M R.1998.Recovery of carotenoids from palm oil by molecular distillation.Computers and Chemical Engineering,22:53-60.
153.Chang Q,Wang X L.2003.Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats.Acta Pharmacol Sin,24(8):796.
154.Chen Y T,et al.1990.Flavonoids as superoxide scavengers and antioxidants.Free Rad Biol Med,9:19-21.
155.Choochote W,Tuetun B,Kanjanapothi D,et al.2004.Potential of crude seed extract ofcelety,Apium graveolens L,against the mosquito Aedes aegypti(L)(Diptera:Culicidae).J Vector Ecol,29(2):340-6.
156.Dahlin M Bergman U,Jansson B,Bjork E,Britebo E.2000.Transfer of dopamine in theolfactory pathway following nasal administration in mice.Pharm Res,17:737-742.
157.De Almeida R N.2004.Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze testin rats.Pharmacology,Biochemistry and Behavior,77(2):361-364.
158.Dionisi F,Hug B,Aeschlimann J M.1999.Supercritical CO_2 extraction for total fat analysis of food products.Journal of Food Science,64(4):612-615.
159.Durak I,Karaayvaz M,Cimen M Y,et al.2001.Aspirin impairs antioxidant system and causes peroxidation in human erythrocytes and guinea pig myocardial tissue.HumExp Toxico,20(1):34-37.
160.Reverchon E,et al.1995.Supercritical CO_2 Extraction and Fractionation of Lavender Essential Oil and Waxes.J Agric Food Chem,43:1654-1658.
161.Siah l E,Schutz E and Mangold K.1980.Extraction of seed oils with liquid and supercritical carbon dioxide.J.Agric.Food Chem,28:1153-1157.
162.Fabre,Cathy E,Marty.1999.Extractive fermentation of aroma with supercritical CO_2.Biotechnology and Bioengineering,64(4):392-400.
163.Favatai F.1991.Supercritical carbon dioxide extraction of evening primrose oil.JAOCS,68(6):422-427.
164.Fereidoon S,X.Q.Han.1993.Encapsulation of Food Ingredients.CRC Reviews in Food Sci and Nutri,33(6):501-547.
165.Food and Agreculture Organization of the Unition Nations.1991.Residues of some veterinary drugs in animals and foods.FAO Food and Nutrition Paper,41(3):85-96.
166.Fozia Anjum,Farooq Anwar,Amer Jamil,M.Iqbal.2006.Microwave roasting effects on the physico-chemical composition and oxidative stability of sunflower seed oil.Journal of the American Oil Chemists'Society,83(9):777-784.
167.Guo C J,Yang J J,Wei JY,et al.2003.Antioxidant activities of peel,pulp and seed fractions of common fruits as determined by FRAP assay.Nutr Res,23:1719.
168.Hogan SA,Mcnamee BF.2001.Microencapsulating properties of whey protein concentrate 75.Journal of Food Science,66(5):675-680.
169.Papamichail;V.Louli;K.Magoulas.2000.Supercritical fluid extraction of celery seed oil.The Journal of Supercritical Fluids,18(3):213-226.
170.In Hwan Kim,Suk Hoo Yoon.1990.Effect of extraction solvents on oxidative stability of crude soybean oil.Journal of the American Oil Chemists'Society,67(3):165-167.
171.Jakovljevic V,Raskovic A,Popovic M,et al.2002.The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism.Eur J Drug Metab Pharmacokinet,27(3):153-6.
172.Jan Cvengios,et al.2000.Modelling of fraction in a molecular evaporator with divided condenser.J Chen Eng,39:191.
173.Jerry W K,James HJ,John PF.1989.Extraction of Fat Tissue from Meat Products With Supercritical Carbon Dioxide.J Agric Food Chem,37:951-954.
174.John P.Friedrich et al.1982.Characterization of soybean oil extracted by supercritical CO_2 and hexane.J.Agric Food Chem,30:192-193.
175.Judie D.Dziezak.1988.Microdencapsulation and encapsulated ingredients.Food Technology,25(4)::136-149.
176.Juraj.Lutisan Miroslaw Micro,Jan Cvengros.1998.The influence of entrainment separator on the process of molecular distillation.Separation Science and Technology,33(1):83.
177.Kayamori F,lgarashi K.1994.Effects of dietary nasunio on the serum cholesterol level in rats.Biosci Biotechnol.Biochem,58:507-571.
178.Kjeld Hermansen,Bo Dinesen,LarsH.Hoie,Eve Morgenstern,Joerg G ruenwald.2003.Effects of soy and other natural products on LDL:HDL ratio and other lipid parameters:A literature review.Advances in:Therapy,20(1):50-78.
179,Ko FN,Huang TF,Teng CM.1991.Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rt thoracic aorta.Biophys Acta,1115(1):69-74.
180.L Cinquanra,M Esti,M Matteo.2001.Oxidative stability of virgin olive oils.Journal of the American Oil Chemists'Society,78(12):1197-1202.
181.Lin LZ,LuS,Harnly JM.2007.Detection and quantification of glycosylated flavonoid malonates in celery,Chinese celery,and celery seed by LC-DAD-ESI/MS.Journal of Agricultural and Food Chemistry,55(4):1321-1326.
182.M.A.Trindade,C.R.F.Grosso.2000.The stability of ascorbic acid microencapsulated in granules of rice starch and in gum Arabic.Journal Microencapsulation,17(2):169-176.
183.Macdonald H,Bedwell B,Gulari E.1986,FTIR spectroscopy of microemulsion structure.Langmuir,2(6):704-708.
184.M.M.Saleh,J.H.Zwaving,Th.M.Malingr6,R.Bos.1985.The essential oil of Apium graveolens vat.secalinum and its cercaricidal activity.Pharmaceutisch Weekblad Scientific Edition,7(6):277-279.
185.M.Z.Ozel,A.A.Clifford.2004.Superheated water extraction of fragrance cornpounds from Rosa canina.Flavour and Fragrance Journal,19(4):354-359.
186.Momin RA,Nair M G.2001.Mosquito cidal nematicidal,and antifungal compounds from Apium graveolens L.seeds.J Agric Food Chem,49(1):142-5.
187.Momin RA,Nair MG.2002.Antioxidant cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn.seeds.Phytomedicine,9(4):312-8.
188.Momin RA,Ramsewak RS,Nair MG.2000.Bioactive compounds and 1,3-Di[(cis)-9-o ctadecenoyl]-2-[(cis,cis)-9,12-o ctadecadienoyl]glycerol from Apium graveolen L.seeds[J].J Agric Food Chem,48(9):3785-8.
189.Moreau DL,Rosenberg M.1996.Oxidative stability of anhydrous milkfat microencapsulated in whey proteins.Food Sci,61(1):39.
190.Mukul Das,KaushalK.Upreti,SubhashK.Khanna.1991.Biochemical toxicology of argemone oil.Role of reactive oxygen species in iron catalyzed lipid peroxidation,46(3):422-430.
191.Nikita Sihag,Asha Kawatra.2003.Hypolipidemic effect of pulse seed coats in rats.Plant Foods for Human Nutrition.58(3):1-1 0.
192.Nurhayat Tabanca,Betul Demirci,Temel Ozek,Nese Kirimer,K.Husnu Can Baser,Erdal Bedir,Ikhlas.Khand,eDavid E.Wedge.2006.Gas chromatographic-mass spectrometric analysis of essential oils from Pimpinella species gathered from Central and Northern Turkey.Journal of Chromatography A,1117:194-205.
193.Pal E.Ho N,Santos C,et al.2003.Red wine polyphenolics Increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human hepG2 cells.J Nutr,133:700.
194.Palmer M.V,Ting.1995.Applications for Supercriticalfluid Technology in Food Processing.Food Chemistry,52:345-352.
195.Papamichail I,Loull V,Mlagoulas K.2000.Supercritical fluid extraction of celery seed oil.The Journal of Suoercritical Fluids,18(3):213-226
196.Pauleti MS,Mestoy P.1999.Butter m icroencapsulation as affected by composition of wall material and fat.J.Food Sci,64(2):279
197.Popovid M,Kaurinovid B,Trivid S,Mimica—Dukid N,Bursa6 M.2006.Effect of celery(Apium graveolens)extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride.Phytother Res,20(7):531-537.
198.Reorge AS,Hao C,Steven JS.1993.Supercritical CO_2 extraction of 13-carotene from sweet potatoes.Food Sci,58(4):817-820.
199.Rezvukin,Berezovikova,Shalaurova,Nikitin.Fatty acid composition of alfalfa seed oil.Chemistry of Natural Compounds,1996,31(4):518.
200.Rincon J,Garcia I,De Lucas.2000.Isolation of rock rose essential oil using supercritical CO_2extraction.Separation Science and Technology,35(16):2745-2763.
201.Roshanai F.1985.Sanders TAB:Influence of different supplements of n-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid.Ann Nutr Metab,29:189.
202.Sovova H,et al.1994.Rate of the vegetable oil extraction with supercritical CO_2 Extraction of grape oil.Chemical Engineering Science,49(3):415-420.
203.S.Sudheesh,G.Presannakumar,S.Vijayakumar,N.R.Vijayalakshmi.1997.Hypolipidemic effect of flavonoids from Solanum melongena.Plant Foods for Human Nutrition,51(4):321-330.
204.Stratton SP,Dorr RT,Alberts DS,et al.2000.The state-of-the-art in chemoprevention of skin cancer.Eur,I Cancer.36(10):1292-1297.
20.5:Szentmihalvi K,Vinkler P,Lakatos B.2002.Rose hip oil obtained from waste hip seeds by different extraction methods Bioresource Technology,82(2):195-201.
206.TammyD Crowe,PamelaJ White.2003.Oxidative stability of walnut oils extracted with supercritical carbon dioxide.Journal of the American Oil Chemists'Society,80(6):575-578.
207.Tong Wang.Yongzhi Jiang,EarlG Hammond.2005.Effect of randomization on the oxidative stability of corn oil.Journal of the American Oil Chemists'Society,82(2):111-117.
208.Tsi D,Das NP,Tan BK.1995.Effects of aqueous celery(Apium graveolens)extract on lipid parameters os rats fed a high fat diet.Planta Med,61(1):18-21.
209.Tsi D,Tan BK.1996:Effects of celery extract and 3-N-butylphthalide on lipid level in gentically hypercholesterolaemic(RICO)rats.Clin Exp Pharmacol Physiol,23(3):214-7.
210.Wei A,Shibamoto T.2007.Antioxidant activities and volatile constituents of various essential oils.Journal of Agricultural and Food Chemistry,55(5):1737-1742.
211.Witschi H,Uyeminami D,Moran D,et al.2000.Chemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposure.Carcinogenesis,21(5):977-982.
212.Witulski B.;Zimmermann A.2002.Synthesis of chiral 3-substituted phthalides via rhodium (1)-catalyzed crossed alkyne cyclotrimerisation.Synlett,(11):1855-1859.
213.Wojciech Kolanowski,Maciej Ziolkowski,Jenny Weiβbrodt.Benno Kunz,G(u|¨)nther Laufenberg.2005.Microencapsulation of fish oil by spray drying--impact on oxidative stability.European Food Research and Technology,222(3):336-342.
214.Yah CH,Fen YP.1998.Effect ofdl-3-n-butylphthalid on striatum cerebral blood flow in normal and middle cerebral artery occlusion rats.Acta Pharmacol Sin,12(1):36-39.
215.Zhang H Y,Chen D Z.2000.Theoretical elucidation on activity differences of ten flavonoid antioxidants.Acta Biochimica Sinica,32(4):317-321.
216.Zheng GQ,Kenney PM,Zhang J,et al.1993.Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil.Nutr Cancer,19(1):77-86.