日粮纤维/淀粉对生长肉兔生长、免疫、肠道菌群的影响及肠道蛋白质组学初探
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摘要
家兔消化道疾病是制约家兔养殖业发展的一个重要因素，由于抗生素的大量使用会造成细菌耐药性和肉制品安全等问题，而通过日粮调控来预防消化道腹泻被普遍认可。根据家兔的生理特点，日粮纤维在家兔饲料组分中占重要地位，饲粮淀粉是主要能量来源，保证家兔健康而又有充分的经济回报是广大养殖户所追求的。因此，日粮中合理的纤维/淀粉在家兔生产中具有重要意义。
本研究选用平均体重相近的断奶新西兰肉兔200只，根据日粮NDF/淀粉为2.3，1.9，1.4，1.0，随机分成4组，每组50只，正式期40天（42-82日龄）。围绕试兔生产指标、盲肠发酵、肠道黏膜发育、特异性及非特异性免疫、肠道微生物多样性及丰度等方面评价了日粮纤维/淀粉对试兔机体内环境的影响，并利用蛋白质组学研究初步探讨了健康与腹泻组试兔肠道蛋白表达差异，综上所述得出以下系列结果：
1.调控NDF/淀粉对试兔生产、盲肠发酵、肠道黏膜发育的影响
各处理组试兔82日龄时，每组选10只屠宰，测定各项相关指标。结果表明：饲粮NDF/淀粉对试兔平均日增重、料重比影响显著（P<0.05），随着NDF/淀粉的降低，平均日增重（ADG）先升高后降低，料重比以日粮Ⅰ组最高(P<0.05)，为4.51:1；饲粮纤维水平对家兔腹泻指数影响极显著（P<0.01），Ⅰ、Ⅱ组腹泻指数最低，在0.026-0.03之间，而第Ⅳ组最高，为3.27。随着NDF/淀粉降低，胃相对重量以日粮Ⅱ组高于与Ⅲ、Ⅳ组，差异显著（p<0.05），但与日粮Ⅰ组差异不显著（P>0.05）。小肠相对重量、胃重、小肠重和胃内容物重各组间差异显著（P<0.05）；四组日粮处理对小肠长度、小肠相对长度、盲肠重、盲肠相对重差异不显著（P>0.05）。盲肠氨氮浓度有随着NDF/淀粉的下降而升高的趋势（P>0.05），NDF/淀粉仅对丙酸的含量有显著影响(P<0.05），对pH、乙酸含量和丁酸含量及乙酸/（丙酸+丁酸）的影响均不显著（P>0.05）；试兔十二指肠肠绒毛的高度随着NDF/淀粉的降低而先升高后降低，在处理组Ⅱ达到最大值，851μm,影响极显著（P<0.01），综上所述，我们认为日粮NDF和淀粉配比在1.9能获得家兔较好的生产性能和胃肠道良好发育。
2.调控NDF/淀粉对试兔非特异性免疫的影响
利用ELISA、流式细胞计数、免疫组化等方法监测试兔分别在52、62、72和82日龄时的非特异性免疫指标变化，结果显示，日龄、日粮和日粮×日龄均对试兔圆小囊和蚓突中M细胞数量影响差异显著（P<0.001），饲喂日粮I（高纤维/低淀粉）的试兔在52-62日龄时，M细胞的数量最高（P<0.001），并且低纤维/高淀粉日粮在家兔52日龄时，M细胞数量最低（P<0.001），试兔62日龄时，除日粮I组外，其他三个日粮各组间M细胞数量差异不显著(P>0.05)。试兔72-82日龄，各日粮处理组间M细胞数量差异均不显著(P>0.05)，在光学显微镜下观察M细胞形态变化发现，62-82日龄日粮Ⅰ组比其它日粮组的M细胞尺寸明显增大；日粮×日龄主要对回肠和十二指肠内SIgA水平的影响有有交互作用，在52和62日龄时，日粮Ⅱ组中试兔回肠内SIgA水平显著最低（P<0.05），其它三组试兔SIgA水平在52日龄时无显著差异（P>0.05），62日龄时日粮Ⅰ组最高。72-82日龄各组差异不显著，而对十二指肠SIgA水平的影响主要集中在72日龄，以日粮Ⅳ组最低（P<0.05）。日粮调控对外周血的IgG水平的影响仅限于82日龄(P=0.05)，而对CD4+/CD8+的影响不显著(P>0.05)。结果表明NDF/淀粉升高可以改善局部肠道黏膜免疫，但仅限于试验早期，对局部黏膜免疫的影响（52-62日龄）早于外周免疫（82日龄）。结合临床腹泻指数认为日粮NDF/淀粉为1.9时可以维护家兔肠道健康。
3.调控NDF/淀粉对试兔肠道菌群发育的影响
分别提取试兔52、62、72和82日龄时各处理组盲肠内细菌总基因组DNA，通过高通量测序技术，获得肠道菌群丰度及多样性等生物学信息，并依据采样时间对不同日粮处理组进行比较。调控NDF/淀粉可以从细菌门的水平改变试兔早期盲肠内不同门类菌群的相对丰度，并改变种属水平的盲肠菌群的多样性及相对丰度。研究得出表明高纤维日粮（日粮Ⅰ）在早期增加了Bacteroidetes门，降低Firmicutes门丰度，而高淀粉日粮（日粮Ⅳ）组Firmicutes菌门丰度在整体试验期较稳定。在种属水平，其中高纤维日粮（日粮Ⅰ、Ⅱ组）盲肠内发现有Escherichia和Bifidobacteria；同时也在日粮Ⅰ、Ⅲ组发现致病性细菌Desulfovibrionales。Ruminococcus内被认为含有大量分解纤维素细菌种类，但是日粮因素对其数量影响不大。主成份分析、聚类分析以及Venn图分析表明82和72日龄时菌群丰度基本趋于一致，共有菌群随日龄增加。DGGE图谱聚类分析结果表明试兔个体间菌群差异较大，但随着年龄的增长，各日粮组菌群逐渐聚到一个分支上。综合上述结果，认为日粮DNF/淀粉在早期（52-62日龄）可以改变肠道菌群的丰度和多样性，当NDF/淀粉为1.9时肠道菌群分布较合理。
4.非病原性腹泻兔与健康兔间蛋白质组学研究
利用二维电泳技术和蛋白质质谱分析技术找出健康与腹泻试兔间的表达差异蛋白，结果发现得出两组共有蛋白数14个，而腹泻组特有的蛋白质点55个；在两组共有蛋白中健康组有13个蛋白点下调，1个蛋白点上调。选出GRP94和а-Smoothmuscleactin两个蛋白做免疫印迹试验印证了蛋白表达结果。结果表明在腹泻状态下а-Smoothmuscleactin蛋白表达上调，GRP94蛋白在腹泻状态下检出，而健康组没有该蛋白表达。
Enteric diseases frequently occur in rabbit restricted the farming development. Due to the extensive use of antibiotics in breeding can lead to bacterial resistance and food safety issues, and consumers as well as breeders require alternative breeding strategies including diet that improve the health of animals without using in-feed antibiotics.
Two hundred weaner rabbits were randomly assigned to4groups(Ⅰ、Ⅱ、 Ⅲ、Ⅳ) with50replicates in each group, in which they were fed each diet with NDF/starch2.3,1.9,1.4,1.0, respectively. Around the trial rabbit production performance, cecal fermentation, gastrointestinal tract development, intestinal membrane shape, non-specific immunity, intestinal microbial diversity and abundance etc, which were determined to evaluate the effect of dietary fiber/starch on rabbit body environment. Proteomics was to explore intestinal protein expression differences between the health and diarrhea group trial rabbits. The results are summarized as follows:
1. The effect of differnt NDF/starch on rabbit production, cecal fermentation, gastrointestinal development
Ten82-day old trial rabbit per treatment group were slaughtered to determined the relevant datas. Dietary NDF/starch had significantly influences on average daily gain (ADG) and feed/gain (F/G)(P<0.05),ADG and F/G deteriorated with decreasing NDF and increasing starch, F/R was the highest(4.51:1) in Diet I (P<0.05); Diarrhea index were affected by dietary NDF/starch (P<0.01), the diarrhea index was the lowest (0.026-0.03) in Diet Ⅰ and Ⅱ and largest in Group Ⅳ(3.27). The stomach weight (g/kg SW), small intestine weight (g/kg SIW) was influenced significantly among all treatment groups (P<0.05), The stomach weight (SW/LW, g/kg), small intestine weight (SIW/LW,g/kg) in Diet Ⅱ all were largest compared to Diet Ⅲ>Ⅳ treatment groups(P<0.05), and no difference with Diet Ⅰ. The NH3-N concentration increased with the descended of dietary NDF/starch, but every treatment had no significant influence (P>0.05); SIW/LW and SW was significant difference among four dietary treatments (P<0.05), while SIL SIL/LW, CW, CW/LW was not significant. Acetic acid was affected significantly by dietary NDF. Dietary NDF/starch had significant influenced illus height of the duodenum (p<0.05) and was the largest in Group Ⅱ (851μm). In conclusion, the appropriate fiber/starch in the diet of weaner to82-day-old growing rabbit is1.9.
2. The effect of different NDF/starch on rabbits' Non-specific immune
Using ELISA, flow cytometry, immunohistochemistry method, the following parameters were assessed:the number of membranous epithelial (M) cells in the appendix, total SIgA titers in the gut, total IgG levels in the serum and the CD4+/CD8+T cell ratio in the peripheral blood; as these measures were taken to determine the effect of diet with age, samples were obtained at52,62,72and82days of age. Monitoring the trail rabbits'non-specific immune changes at52,62,72,82days of age, respectively. The effect of Diet×age on trail rabbits'M cells number had significantly different (P<0.001). The number of M cells was the highest in Diet I at52and62days of age (P<0.00\), while was the lowest in Diet Ⅳ at52days (P<0.001). However, at72and82days of age, there was no difference (P>0.05) in M cell number among the four diets treatments. Using immunohistochemistry, the high fiber/low starch diet (Diet I) resulted in an increase in M cell size and number when compared with the other diets. Diet×age effected on SIgA levels in the ileum and duodenum at52and62days (P<0.05), which was no difference at72-82days of age. The SIgA level change of duodenal mainly concentrated in the72days of age and the diet IV group had the lowest (P<0.05). Serum IgG titers were only affected (P=0.05) at82days of age. The ratio of CD4+/CD8+T cells in the peripheral blood was not affected. The study revealed that increased levels of fiber might improve mucosal functionality, but only during the early stage of growth of rabbits. The effect of dietary fiber/starch levels on intestinal immunity was greater than their effect on humoral immunity in the peripheral blood. Combined with clinical diarrhea index,dietary NDF/starch1.9rabbits can maintain intestinal health.
3. The effect of different NDF/starch on trail rabbit intestinal flora abundance and diversity
In this work, we used a pyrosequencing-based analysis of16S rRNA genes to compare the cecal microbiota of rabbits fed diets containing different dietary fiber/starch ratio to determine the how the overall microbiome structure varies according to age (from52to82days of age) and diet. The different categories of bacterial phyla and species relative abundance in rabbits'cecum can be changed in early period through regulating NDF/starch. Research results show that high-fiber diets (Diet I) increased the abundance of Bacteroidetes phyla and decreased the abundance of Firmicutes during early peirod, While the abuandance of Firmicutes phyla bacteria from high-starch diet (diet IV) group was relatively stable in trial period. In the species level, including high-fiber diet (Diet Ⅰ,Ⅱ) were found Escherichia and Bifidobacteria in rabbits' cecum,While found Desulfovibrionales for pathogenic bacteria from Diet Ⅰ, Ⅲ group.the cellulose-decomposing bacteria belonging to the genus Ruminococcus which are not affected by the composition of the diet. A weighted UniFrac analysis revealed that abundance of the gut microbiome was similar at72and82days old. A hierarchical clustering heatmap analysis based on the bacterial community profiles at the family level revealed that the major samples at72and82days of age grouped together. By Venn diagram, all samples have more OTUs in common at72and82days of age. DGGE profiles cluster analysis results show that the individual flora difference among trial rabbit was found. However, flora from all diets treatments gradually gathered a branch with aging. Conclusions:Our data suggest that the bacterial community in the rabbit cecum is able to change and adapt gradually to reach a new equilibrium in response to a nutritional disturbance. More reasonable distribution of intestinal flora was established when the NDF/starch1.9.
4. Intestinal proteomics research between Non-pathogenic diarrhea rabbit and health rabbit
Under the application of two-dimensional gel electrophoresis and mass ctrometry experiments,we finally obtained organization different proteins of14shared proteins of health, including1up-regulated protein and13proteins down in health rabbits. With the application of two-dimensional LC-MS analysis, we could obtain55specific protein of diarrhea group. In order to confirm the accuracy of our experiment, we selected two proteins (GRP94, a-Smooth muscle actin) among health and diarrhea rabbits' tissues by Dimensional gel electrophoresis and mass spectrometry experiments respectively and verified the accuracy of two-dimensional gel electrophoresis by immunity signature experiment. We verified the accuracy of Two-dimensional LC-MS experiment by immunity signature.
本研究选用平均体重相近的断奶新西兰肉兔200只，根据日粮NDF/淀粉为2.3，1.9，1.4，1.0，随机分成4组，每组50只，正式期40天（42-82日龄）。围绕试兔生产指标、盲肠发酵、肠道黏膜发育、特异性及非特异性免疫、肠道微生物多样性及丰度等方面评价了日粮纤维/淀粉对试兔机体内环境的影响，并利用蛋白质组学研究初步探讨了健康与腹泻组试兔肠道蛋白表达差异，综上所述得出以下系列结果：
1.调控NDF/淀粉对试兔生产、盲肠发酵、肠道黏膜发育的影响
各处理组试兔82日龄时，每组选10只屠宰，测定各项相关指标。结果表明：饲粮NDF/淀粉对试兔平均日增重、料重比影响显著（P<0.05），随着NDF/淀粉的降低，平均日增重（ADG）先升高后降低，料重比以日粮Ⅰ组最高(P<0.05)，为4.51:1；饲粮纤维水平对家兔腹泻指数影响极显著（P<0.01），Ⅰ、Ⅱ组腹泻指数最低，在0.026-0.03之间，而第Ⅳ组最高，为3.27。随着NDF/淀粉降低，胃相对重量以日粮Ⅱ组高于与Ⅲ、Ⅳ组，差异显著（p<0.05），但与日粮Ⅰ组差异不显著（P>0.05）。小肠相对重量、胃重、小肠重和胃内容物重各组间差异显著（P<0.05）；四组日粮处理对小肠长度、小肠相对长度、盲肠重、盲肠相对重差异不显著（P>0.05）。盲肠氨氮浓度有随着NDF/淀粉的下降而升高的趋势（P>0.05），NDF/淀粉仅对丙酸的含量有显著影响(P<0.05），对pH、乙酸含量和丁酸含量及乙酸/（丙酸+丁酸）的影响均不显著（P>0.05）；试兔十二指肠肠绒毛的高度随着NDF/淀粉的降低而先升高后降低，在处理组Ⅱ达到最大值，851μm,影响极显著（P<0.01），综上所述，我们认为日粮NDF和淀粉配比在1.9能获得家兔较好的生产性能和胃肠道良好发育。
2.调控NDF/淀粉对试兔非特异性免疫的影响
利用ELISA、流式细胞计数、免疫组化等方法监测试兔分别在52、62、72和82日龄时的非特异性免疫指标变化，结果显示，日龄、日粮和日粮×日龄均对试兔圆小囊和蚓突中M细胞数量影响差异显著（P<0.001），饲喂日粮I（高纤维/低淀粉）的试兔在52-62日龄时，M细胞的数量最高（P<0.001），并且低纤维/高淀粉日粮在家兔52日龄时，M细胞数量最低（P<0.001），试兔62日龄时，除日粮I组外，其他三个日粮各组间M细胞数量差异不显著(P>0.05)。试兔72-82日龄，各日粮处理组间M细胞数量差异均不显著(P>0.05)，在光学显微镜下观察M细胞形态变化发现，62-82日龄日粮Ⅰ组比其它日粮组的M细胞尺寸明显增大；日粮×日龄主要对回肠和十二指肠内SIgA水平的影响有有交互作用，在52和62日龄时，日粮Ⅱ组中试兔回肠内SIgA水平显著最低（P<0.05），其它三组试兔SIgA水平在52日龄时无显著差异（P>0.05），62日龄时日粮Ⅰ组最高。72-82日龄各组差异不显著，而对十二指肠SIgA水平的影响主要集中在72日龄，以日粮Ⅳ组最低（P<0.05）。日粮调控对外周血的IgG水平的影响仅限于82日龄(P=0.05)，而对CD4+/CD8+的影响不显著(P>0.05)。结果表明NDF/淀粉升高可以改善局部肠道黏膜免疫，但仅限于试验早期，对局部黏膜免疫的影响（52-62日龄）早于外周免疫（82日龄）。结合临床腹泻指数认为日粮NDF/淀粉为1.9时可以维护家兔肠道健康。
3.调控NDF/淀粉对试兔肠道菌群发育的影响
分别提取试兔52、62、72和82日龄时各处理组盲肠内细菌总基因组DNA，通过高通量测序技术，获得肠道菌群丰度及多样性等生物学信息，并依据采样时间对不同日粮处理组进行比较。调控NDF/淀粉可以从细菌门的水平改变试兔早期盲肠内不同门类菌群的相对丰度，并改变种属水平的盲肠菌群的多样性及相对丰度。研究得出表明高纤维日粮（日粮Ⅰ）在早期增加了Bacteroidetes门，降低Firmicutes门丰度，而高淀粉日粮（日粮Ⅳ）组Firmicutes菌门丰度在整体试验期较稳定。在种属水平，其中高纤维日粮（日粮Ⅰ、Ⅱ组）盲肠内发现有Escherichia和Bifidobacteria；同时也在日粮Ⅰ、Ⅲ组发现致病性细菌Desulfovibrionales。Ruminococcus内被认为含有大量分解纤维素细菌种类，但是日粮因素对其数量影响不大。主成份分析、聚类分析以及Venn图分析表明82和72日龄时菌群丰度基本趋于一致，共有菌群随日龄增加。DGGE图谱聚类分析结果表明试兔个体间菌群差异较大，但随着年龄的增长，各日粮组菌群逐渐聚到一个分支上。综合上述结果，认为日粮DNF/淀粉在早期（52-62日龄）可以改变肠道菌群的丰度和多样性，当NDF/淀粉为1.9时肠道菌群分布较合理。
4.非病原性腹泻兔与健康兔间蛋白质组学研究
利用二维电泳技术和蛋白质质谱分析技术找出健康与腹泻试兔间的表达差异蛋白，结果发现得出两组共有蛋白数14个，而腹泻组特有的蛋白质点55个；在两组共有蛋白中健康组有13个蛋白点下调，1个蛋白点上调。选出GRP94和а-Smoothmuscleactin两个蛋白做免疫印迹试验印证了蛋白表达结果。结果表明在腹泻状态下а-Smoothmuscleactin蛋白表达上调，GRP94蛋白在腹泻状态下检出，而健康组没有该蛋白表达。
Enteric diseases frequently occur in rabbit restricted the farming development. Due to the extensive use of antibiotics in breeding can lead to bacterial resistance and food safety issues, and consumers as well as breeders require alternative breeding strategies including diet that improve the health of animals without using in-feed antibiotics.
Two hundred weaner rabbits were randomly assigned to4groups(Ⅰ、Ⅱ、 Ⅲ、Ⅳ) with50replicates in each group, in which they were fed each diet with NDF/starch2.3,1.9,1.4,1.0, respectively. Around the trial rabbit production performance, cecal fermentation, gastrointestinal tract development, intestinal membrane shape, non-specific immunity, intestinal microbial diversity and abundance etc, which were determined to evaluate the effect of dietary fiber/starch on rabbit body environment. Proteomics was to explore intestinal protein expression differences between the health and diarrhea group trial rabbits. The results are summarized as follows:
1. The effect of differnt NDF/starch on rabbit production, cecal fermentation, gastrointestinal development
Ten82-day old trial rabbit per treatment group were slaughtered to determined the relevant datas. Dietary NDF/starch had significantly influences on average daily gain (ADG) and feed/gain (F/G)(P<0.05),ADG and F/G deteriorated with decreasing NDF and increasing starch, F/R was the highest(4.51:1) in Diet I (P<0.05); Diarrhea index were affected by dietary NDF/starch (P<0.01), the diarrhea index was the lowest (0.026-0.03) in Diet Ⅰ and Ⅱ and largest in Group Ⅳ(3.27). The stomach weight (g/kg SW), small intestine weight (g/kg SIW) was influenced significantly among all treatment groups (P<0.05), The stomach weight (SW/LW, g/kg), small intestine weight (SIW/LW,g/kg) in Diet Ⅱ all were largest compared to Diet Ⅲ>Ⅳ treatment groups(P<0.05), and no difference with Diet Ⅰ. The NH3-N concentration increased with the descended of dietary NDF/starch, but every treatment had no significant influence (P>0.05); SIW/LW and SW was significant difference among four dietary treatments (P<0.05), while SIL SIL/LW, CW, CW/LW was not significant. Acetic acid was affected significantly by dietary NDF. Dietary NDF/starch had significant influenced illus height of the duodenum (p<0.05) and was the largest in Group Ⅱ (851μm). In conclusion, the appropriate fiber/starch in the diet of weaner to82-day-old growing rabbit is1.9.
2. The effect of different NDF/starch on rabbits' Non-specific immune
Using ELISA, flow cytometry, immunohistochemistry method, the following parameters were assessed:the number of membranous epithelial (M) cells in the appendix, total SIgA titers in the gut, total IgG levels in the serum and the CD4+/CD8+T cell ratio in the peripheral blood; as these measures were taken to determine the effect of diet with age, samples were obtained at52,62,72and82days of age. Monitoring the trail rabbits'non-specific immune changes at52,62,72,82days of age, respectively. The effect of Diet×age on trail rabbits'M cells number had significantly different (P<0.001). The number of M cells was the highest in Diet I at52and62days of age (P<0.00\), while was the lowest in Diet Ⅳ at52days (P<0.001). However, at72and82days of age, there was no difference (P>0.05) in M cell number among the four diets treatments. Using immunohistochemistry, the high fiber/low starch diet (Diet I) resulted in an increase in M cell size and number when compared with the other diets. Diet×age effected on SIgA levels in the ileum and duodenum at52and62days (P<0.05), which was no difference at72-82days of age. The SIgA level change of duodenal mainly concentrated in the72days of age and the diet IV group had the lowest (P<0.05). Serum IgG titers were only affected (P=0.05) at82days of age. The ratio of CD4+/CD8+T cells in the peripheral blood was not affected. The study revealed that increased levels of fiber might improve mucosal functionality, but only during the early stage of growth of rabbits. The effect of dietary fiber/starch levels on intestinal immunity was greater than their effect on humoral immunity in the peripheral blood. Combined with clinical diarrhea index,dietary NDF/starch1.9rabbits can maintain intestinal health.
3. The effect of different NDF/starch on trail rabbit intestinal flora abundance and diversity
In this work, we used a pyrosequencing-based analysis of16S rRNA genes to compare the cecal microbiota of rabbits fed diets containing different dietary fiber/starch ratio to determine the how the overall microbiome structure varies according to age (from52to82days of age) and diet. The different categories of bacterial phyla and species relative abundance in rabbits'cecum can be changed in early period through regulating NDF/starch. Research results show that high-fiber diets (Diet I) increased the abundance of Bacteroidetes phyla and decreased the abundance of Firmicutes during early peirod, While the abuandance of Firmicutes phyla bacteria from high-starch diet (diet IV) group was relatively stable in trial period. In the species level, including high-fiber diet (Diet Ⅰ,Ⅱ) were found Escherichia and Bifidobacteria in rabbits' cecum,While found Desulfovibrionales for pathogenic bacteria from Diet Ⅰ, Ⅲ group.the cellulose-decomposing bacteria belonging to the genus Ruminococcus which are not affected by the composition of the diet. A weighted UniFrac analysis revealed that abundance of the gut microbiome was similar at72and82days old. A hierarchical clustering heatmap analysis based on the bacterial community profiles at the family level revealed that the major samples at72and82days of age grouped together. By Venn diagram, all samples have more OTUs in common at72and82days of age. DGGE profiles cluster analysis results show that the individual flora difference among trial rabbit was found. However, flora from all diets treatments gradually gathered a branch with aging. Conclusions:Our data suggest that the bacterial community in the rabbit cecum is able to change and adapt gradually to reach a new equilibrium in response to a nutritional disturbance. More reasonable distribution of intestinal flora was established when the NDF/starch1.9.
4. Intestinal proteomics research between Non-pathogenic diarrhea rabbit and health rabbit
Under the application of two-dimensional gel electrophoresis and mass ctrometry experiments,we finally obtained organization different proteins of14shared proteins of health, including1up-regulated protein and13proteins down in health rabbits. With the application of two-dimensional LC-MS analysis, we could obtain55specific protein of diarrhea group. In order to confirm the accuracy of our experiment, we selected two proteins (GRP94, a-Smooth muscle actin) among health and diarrhea rabbits' tissues by Dimensional gel electrophoresis and mass spectrometry experiments respectively and verified the accuracy of two-dimensional gel electrophoresis by immunity signature experiment. We verified the accuracy of Two-dimensional LC-MS experiment by immunity signature.
引文
鲍国连,佟承刚,韦强,陶争荣,季权安,家兔大肠杆菌所致腹泻机体理化参数变化及病理特性研究.中国养兔杂志,2001,1(20)：20-22
单永利.现代养兔.中国农业出版社出版,2004,150-151
董亚芳.家兔腹泻病主要病原及防治对策(上).中国养兔杂志,1992,(2)：3-5
高静华.两种不同来源颗粒料对幼兔生长影响的比较.上海畜牧兽医通讯,1995,(1)：31
金岭梅.日粮粗纤维水平对兔饲料转化率的影响.甘肃畜牧兽医,1994：6
李福昌.家兔营养.中国农业出版社,2009,11
卢德勋.饲粮纤维的营养作用及其利用.饲料营养研究进展(中国畜牧兽医学会动物营养学分会第三届饲料营养学术研讨会论文集).成都,亚洲中医药杂志社,1998,13-23
罗茜和曹伟新.白蛋白的临床应用及在营养治疗中的意义.中国临床营养杂志,2007,15(5)：315-318
秦应和,王俐,柯尊伟,等.家兔对不同品质粗纤维利用能力的研究.饲料研究,2000,(2)：5-7
唐良美,谢晓红,刘曼丽,李红.家兔饲料消化率测定方法的研究.中国养兔杂志,1991(2)：9-17
王兴春,杨致荣,王敏,李玮,李生才.高通量测序技术及其应用,中国生物工程杂志,2012,(32)：109-114
吴秋珏.饲粮中中性洗涤纤维的研究进展.饲料工业,2006,(27)：14-18
周秀菊,刘党生,蒋宇扬.肌酸激酶结构与功能研究进展.沈阳药科大学学报,2002,(19)：386-393
祝素珍,李福昌.2-3月龄肉兔日粮消化能水平对消化代谢和产肉性能影响的研究.动物营养学报.2004,16(4)：51-57
Abecia L., Fondevila M., Balcells J., Edwards J.E., Newbold C.J., McEwan N.R.. Molecular profiling of bacterial species in the rabbit caecum. FEMS Microbiol. Lett.,2005,(244):111-115
Abecia L., Fondevila M., Balcells J., Edwards J.E., Newbold C.J., McEwan N.R.. Effect of antibiotics on the bacterial population of the rabbit caecum. FEMS Microbiol. Lett.,2007a,(272):144-153
Abecia L., Fondevila M., Balcells J., Lobley G.E., McEwan N.R.. The effect of medicated diets and level of feeding on caecal microbiota of lactating rabbit does. J. Appl. Microbiol.,2007b,(103):787-793
Abecia L., Fondevila M., Balcells J., McEwan N.R.The effect of lactating rabbit does on the development of the caecal microbial community in the pups they nurture. J. Appl. Microbiol,2007c,(103):557-564
Aboul-Ela S.. Effect of dietary fiber and energy levels on performance of post. World Rabbit Science,2008,(Suppli):61
Abreu-Martin M.T., Targan S.R.. Regulation of immune responses of the intestinal mucosa. Crit. Rev. Immunol,1996,(16):227-309
Adjiri D., Bouillier Oudot M., Lebas F., Candau M.. Simulation in vitro des fermentations caecales du lapin en fermenteur a flux semi-continu.1. Role du pretraitement du substrat alimentaire. Reprod. Nutr. Dev.,1992,(32):351-360
Almendral J.M., Santaren J.F., Perera J., Zerial M., Bravo R..Expression, cloning and cDNA sequence of a fibroblast serumregulated gene encoding a putative actin-associated protein (p27). Exp. Cell Res,1989,(181):518-530
Alanen H. I., Williamson R. A., Howard M. J., Hatahet F.S., Salo K.E.H., Kauppila A.,Kellokumpu S. and Ruddock L.W.. ERp27, a new non-catalytic endoplasmic reticulum-locatedhuman protein disulfide isomerase family member,interacts with ERp57. J. Biol. Chem.,2006,(281):33727-33738.
Alpers C.E., Hudkins K.L., Gown A.M., Johnson R.J.. Enhanced expression of "muscle-specific" actin in glomerulonephritis. Kidney Int.,1992,(41):1134-1142
Alpers C.E., Pichler R., Johnson R.J.. Phenotypic features of cortical interstitial cells potentially important in fibrosis. Kidney Int.,1996,(49):S-28-31
Altieri D.C., Duperray A., Plescia J., Thornton G.B. and Languino L.R.. Structural Recognition of a Novel Fibrinogen Chain Sequence (117133) by Intercellular Adhesion Molecule-1Mediates Leukocyte-Endothelium Interaction. J. Biol. Chem.,1995,(2):696-699.
Appenzeller-Herzog C., Ellgaard L.. The human PDI family:Versatility packed into a single fold. Biochim. Biophys. Acta.,2008,(1783):535-548
Argenzio R. A..Physiology of diarrhea-large intestine. JAVMA,1978,(5):667-672
Arora P.D., N. Narani and C.A. McCulloch. The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fi broblasts. Am.J.Pathol,1999,(154):871-882
Asp N.G., Johansson C.G.. Dietary fibre analysis. Nutrition Abstract Review,1984,(54):735-752
Backhed F., Ding H., Wang T., Hooper L. V., Koh G. Y., Nagy A, Semenkovich C. F. and Gordon J.. The gut microbiota as an environmental factor that regulates fat storage. PNAS,2004,(101):15718-15723
Bennegadi N., Fonty G., Millet L., Gidenne T., Licois D.. Effects of age and dietary fibre level on caecal microbial communities of conventional and specific pathogen-free rabbits. Microbial Ecology in Health and Disease,2003,(5):23-32
Bennegadi N., Gidenne T., Licois L.. Impact of fibre deficiency and sanitary status on non-specific enteropathy of the growing rabbit. Anim. Res.,2001,(50):401-413
Bennegadi, N.. Non specific enteropathies in growing rabbit:Impacts of microbial and nutritional factors. PhD thesis, Institut National Polytechnique, Toulouse,2002:161
Beong O. L., Koji Y., Michiko N., Yuichiro K., Pham H. And Michihiro S.. Dietary Fibers Modulate Indices of Intestinal Immune Function in Rats. J. Nutr.,1997,(127):663-667
Blas E., Cervera C., Fernandez Carmona J.. Effect of two diets with varied starch and fibre levels on the performances of4-7weeks old rabbits. World Rabbit Sci.,1994,(2)117-121
Borghesi C., Taussig M. J., Nicoletti C.. Rapid appearance of M cells after microbial challenge is restricted at the periphery of the follicle-associated epithelium of Peyer's patch. Lab. Invest.,1999,(79):1393-1401
Boulahrouf A., Fonty G., Gouet P.. Establishment, counts and identification of the fibrolytic bacteria in the digestive tract of rabbit. Influence of feed cellulose content. Current microb.,1991,(22):1-25
Bosschaerts T., Guilliams M., Noel W., Herin M., Burk R.F., Hill K.E.,Brys L., RAES G., Ghassabeh G.H., Baetselier R.D. and Beschin A..Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10inducible gene selenoprotein P.J. Immunol.,2008,(180):6168-6175
Burk R.F., Hill K.E., Selenoprotein P-expression, functions, and roles in mai' nmals. Biochim. Biophys. Acta.,2009,(1790):1441-1447
Cabanes D., Sousa S., Cebria A., Lecuit M., Garcia-del Portillo F.&Cossart P.. Gp96is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein. EMBO J.,2005,(24):2827-2838
Carabano R., Badiola I., Chamorro S., Garcia J., Garcia-Ruiz A.I., Garcia-Rebollar P. Gomez-Conde M. S., Gutierrez I., Nicodemus N., Villamide M. J., De Blas J. C..New trends in rabbit feeding:influence of nutrition on intestinal health. Span. J. Agric. Res.(Special issue J. M. Malpica),2008,(6):15-25
Carabano R., Garcia J., De Blas J.C.. Effect of fibre source on ileal apparent digestibility of non-starch polysaccharides in rabbits. Anim. Sci.,2001,(72):343-350
Carpita N.C., Gibeaut D.M.. Structural models of primary cell walls in flowering plants: consistency of molecular structure with the physical properties of the walls during growth. Plant J.,1993,(3):1-30
Carpita N.C.. Structure and biogenesis of the cell walls of grasses. Annual Review of Plant Physiology and Plant Molecular Biology,1996,(47):445-476
Chamorro S., Gomez-Conde M.S., Perez de Rozas A.M., Carabano R., De Blas J.C.. Effect on digestion andperfomance of dietary protein content and of increased substitution of lucerne hay with soya-bean protein concentrate in starter diets fo young rabbits. Animal,2007,(1):651-659
Chao G.T.,O'Leary-Kelly A.M.,Wolf S..Organizational socialization:its content and consequences.JAP,1994,(79):730-743
Chao H.Y., Li F.C.. Effect of level of fibre on performance and digestion traits in growing rabbits. Animal Feed Science and Technology,2008,(144):279-291
Cheeke P.R., Patton N.M., Carbohydrate overload of the hindgut. A probable cause of enteritis. J. Appl. Rabbit Res.,1980,(3):20-23
Cheeke PR..Rabbit feeding and nutrition. Academic Press,USA,1987
Chesson A.. Dietary fiber. In:Stephen, A.M.(Ed.), Food polysaccharides and their applications. Marcel Dekker, New York,1995:547-576
Chiou P.W.S., Yu B., Lin C.. Effect of different components of dietary fibre on the intestinal morphology of domestic rabbits. Comp. Biochem. Physiol. A,1994,(108):629-638
Clark M. A., Hirst B. H., Jepson M. A.. Lectin-mediated mucosal delivery of drugs and microparticles. Adv. Drug Deliv. Rev.,2000,(43):207-223
Clark M.A., Jepson M.A., Hirst B.H.. Exploiting M cells for drug and vaccine delivery. Adv. Drug Deliv. Rev,2001,(50):81-106
Clark M.A., Jepson M.A., Simmons N.L., Booth T.A., Hirst B.H.. Differential expression of lectin-binding sites defines mouse intestinal M-cells. J. Histochem. Cytochem.,1993,(41):1679-1687
Clark M.A., Jepson M.A.. Intestinal M cells and their role in bacterial infection. Int. J. Med. Microbiol.,2003,(293):17-39
Combes S., Fortun-Lamothe L., Cauquil L., Gidenne T.. Controlling the rabbit digestive ecosystem to improve digestive health and efficacy. Proceedings10th World Rabbit Congress September3-6,2012-Sharm El-Sheikh-Egypt,2012:475-494
Combes S., Michelland R.J., Monteils V., Cauquil L., Soulie V., Tran N.U., Gidenne T. Fortun-Lamothe L.. Postnatal development of the rabbit caecal microbiota composition and activity. FEMS Microbiol. Ecol,2011,(77):680-689
Corthier G.. Bonnes bacteries et bonne sante.Quae ed.Versailles,2011,(2):128
Coudert P., Licois D. and Besnard J.. Establishment of a specified pathogen free breeding colony (SPF) without hysterectomy and hand-rearing procedures. In:Proc.4th Congress of the World Rabbit Science Assoc.,10-14October,1988:137-148
Cummings J.H.. Short chain fatty acids in the human colon.Gut.,1981,(22):763-779
Daly K., Stewart C.S., Flint H.J., Shirazi-Beechey S.P.. Bacterial diversity within the equine large intestine as revealed by molecular analysis of cloned16S rRNA genes. FEMS Microbiol. Ecol,2001,(38):141-151
Danninger C., Gimona M.. Live dynamics of GFP-calponin:Isoform-specific modulation of the actincytoskeleton and autoregulation by C-terminal sequences. J. Cell Sci.,2000,(113):3725-3736
De Arruda A.M.V., Lopes D.C., Ferreira W.M., Rostagno H.S., Queiroz A.C., Pereira E.S., Albino L.F.T. and Da Silva J.F.. Digestibilidade aparente dos nutrientes de racoes contendo diferentes fontes de fibra e niveis de amido com coelhos em crescimento. Revista Brasileira de Zootecnia,2002,(31):1166-1175
De Blas C, Mateos G.G.. Feed formulation In:De Blas C., Wiseman J.J.(Eds).The nutrition of the rabbit. New York:CABI Publishing,1998:241-253
De Blas J.C., Santoma G.,Carabno R.and Fraga M. J.. Fiber and starch levels in fattening rabbit diets.Journal of Animal Science,1986,(63):1897-1904
De Vries J.W., Prosky L., Li B., Cho S.. A historical perspective on defining dietary fiber. Cereal Foods World,1999,(44):367-369
Didierlaurent A., Sirard J. C, Kraehenbuhl J. P., Neutra M. R.. How the gut senses its content. Cell. Microbiol,2002,(4):61-72
Dorsey C.W., Laarakker M.C., Humphries A.D., Weening E.H.&Baumler A.J.. Salmonella enterica serotype Typhimurium MisL is an intestinal colonization factor that binds fibronectin. Mol Microbiol,2005,(57):196-211
Dowd S.E., Callaway T.R., Wolcott R.D., Sun Y., McKeehan T., Hagevoort R.G and Edrington T.S.. Evaluation of the bacterial diversity in the feces of cattle using16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP).BMC Microbiology,2008,(8):125
Doweiko J.P., Nompleggi D.J.. Role of albumin in human physiology and pathophysiology.J. Parent Ent. Nutr.,1991,15(2):207-211
Eliasson A.C. and Gudmundsson M.. Starch:physicochemical and functional aspects.In: Eliasson,A.C.(Ed) Carbohydrates in Food. Marcel Dekker Inc, Basel,Switzerlan,1996:431-503
Ellgaard L.,Ruddock L. W.. The human protein disulphide isomerase family:substrate interactions andfunctional properties. EMBO Rep.,2005,(6):28-32
Ermak T. H., Giannasca P. J.. Microparticle targeting to M cells. Adv. Drug Deliv. Rev.,1998,(34):261-283
Ermak T.H., Bhagat H.R., Pappo J.. Lymphocyte compartments in antigen-sampling regions of rabbit mucosal lymphoid organs. Am. J. Trop. Med. Hyg.,1994,(50):14-28 Evolution,1988,(42):387-391FAOSTAT,2011
Farfan M.J., Inman K.G.&Nataro J.P.. The major pilin subunit of the AAF/II fimbriae from enteroaggregative Escherichia coli mediates binding to extracellular matrix proteins. Infect Immun.,2008,(76):4378-4384
Feyzullah Beyaz E., Erggun A. G., Bayraktaroglu L., Ergun. The identification of intestinal M cells in the sacculus rotundus and appendix of the Angora rabbit. Vet. Res. Commun.,2010,(34):255-265
Field C.J., McBurneya M.I., Massiminob S., Hayekb M.G., and Sunvold G.D.. The fermentable fiber content of the diet alters the function and composition of canine gut associated lymphoid tissue. Vet. Immunol. Immunopathol.,1999,(72):325-341
Fischer S.G., Lerman L.S..DNA fragmentdiffering by single basepair substitutions are separated in denaturing gradientgels:correspondencewithmelting theory.Proc. Natl.Acad.
Fonty G., Gouet P., Riou Y.. Effect of milk composition on the gastrointestinal microflora of the rabbit. Ann Biol Anim. Bioch. Biophys,1979,(19):567-571
Fonty G., Gouet P..Fibre-degradating microorganisms in the monogastric digestive trac. Anim. Feed Sci. Technol.,1989,(23):91-107
Forsythe S.J., Parker D.S.. Nitrogen metabolism by the microbial flora of the rabbit. J. Appl. Bacteriology.,1985,(58):363-369
Fu Y.P., Liu H.W., Forsythe S.M., Kogut P., McConville J.F., Halayko A.J., Camoretti-Mercado B. and Solway J.,. Mutagenesis analysis of human SM22: characterization of actin binding. J. Appl. Physiol.,2000,(89):1985-1990
Gallois M., Fortun-Lamothe L., Michelan A. and Gidenne T.. Adaptability of the digestive function according to age at weaning in the rabbit:Ⅱ. Effect on nutrient digestion in the small intestine and in the whole digestive tract. Animal,2008,(2):536-547
Garcia J., Carabano R., De Blas J. C. Effect of fibre source on cell wall digestibility and rate of passage in rabbits. Animal Sciecne,1999,(77):898-905
Garcia J., Carabano R., Perez-Alba L., De Blas J.C.. Effect of fiber source on cecal fermentation and nitrogenrecycled through cecotrophy in rabbits. J. Anim. Sci.,2000,(78):638-646
Garcia J., Gidenne T., Falcao-e-Cunha L. and de Blas C.. Identification of the main factors that influence caecal fermentation traits in growing rabbits. Animal Research,2002,(51):165-173
Gebert A., Hach G., Bartels H.. Co-localization of vimentin and cytokeratins in M-cells of rabbit gutassociated lymphoid tissue (GALT). Cell Tissue Res.,1992,(269):331-340
Gebert A., Pabst R.. M cells at locations outside the gut. Semin. Immunl,1999,(11):165-170
Gebert A., Posselt W.. Glycoconjugate expression defines the origin and differentiation pathway of intestinal M-cells. J. Histochem. Cytochem.,1997,(45):1341-1350
Gebert A., Rothkotter H. J., Pabst R.. M cells in Peyer's patches of the intestine. Int. Rev. Cytol.,1996,(167):91-159
Gebert A., Steinmetz I., Fassbender S., Wendlandt K.H.. Antigen transport into Peyer's patches:Increased uptake by constant numbers of M cells. Am. J. PathoL.,2004,(164):65-72
Gibson G., Roberfroid M.. Dietary modulation of the human colonic microbiota:introducing the concept of prebiotics. J. Nutr.,1995,(125):1401-1412
Giddene T., Garcia J.. Nutritional strategies improving the digestive health of he weaned rabbits. In:Maertens L,Coudert P, editors. Recent Advances in rabbit sciences. ILVO, Merelbeke, Belgium,2006:229-238
Gidenne T., Arveux P., Madec O.. The effect of the quality of dietary lignocellulose on digestion, zootechnical performance and health of the growing rabbit. Anim. Sci.,2001,(73):97-104
Gidenne T., Bellier R., Van Eys J.. Effect of the dietary fibre origin on the digestion and on the caecal fermentation pattern of the growing rabbit. Anim. Sci.,1998,(66):509-517
Gidenne T., Bellier R.. Use of digestible fibre in replacement to available carbihydrates-Effect on digestion, rate of passage and caecal fermentation pattern during the growth of the rabbit. Livest. Prod. Sci.,2000,(63):141-152
Gidenne T., Combes S., Licois D., Carabano R., Badiola I., Garcia J.. Ecosysteme caecal et nutrition du lapin:interactions avec la sante digestive. INRA Prod. Anim.,2008,(21):239-250
Gidenne T., Debray L., Fortun-Lamothe L., Le Huerou-Luronz I..Maturation of the intestinal digestion and of microbial activity in the young rabbit:Impact of the dietary fibre:starch ratio. Comparative Biochemistry and Physiology, Part A,2007,(148):834-844
Gidenne T., Garcia J., Lebas F., Licois D.. Nutrition and feeding strategy:interactions with pathology. In:De Blas C, Wiseman J,editors. CABI:Nutrition of the rabbit.,2010a179-199
Gidenne T., Jehl N., Lapanouse A., Segura M.. Inter-relationship of microbial activity, digestion and gut health in the rabbit:effect of substituting fibre by starch in diets having a high proportion of rapidly fermentable polysaccharides. Brit. J. Nutr.,2004a,(92)95-104
Gidenne T., Jehl N., Perez J.M., Arveux P., Bourdillon A., Mousset J.L., Duperray J., Stephan S. and Lamboley B.. Effect of cereal sources and processing in diets for the growing rabbits. Ⅱ. Effects on performance and mortality by enteropathy. Animal Research,2005b,(54):65-72
Gidenne T., Jehl N., Segura M., Michalet-Doreau B.. Microbial activity in the caecum of the rabbit around weaning:impact of a dietary fibre deficiency and of intake level. Animal Feed Science and Technology,2002,(99):107-118
Gidenne T., Jehl N.. Re'ponse zootechnique du lapin en croissance face aune reduction de l'apport de fibres, dans des re'gimes riches en fibres digestibles. In:Perez, J.M.(Ed.),8e me J.Rech Cunicoles Fr.,9-10June. ITAVI, Paris,1999:109-113
Gidenne T., Lebas F., Fortun-Lamothe L.. Feeding behaviour of rabbits. In:De Blas, C., Wiseman, J.(Ed.), Nutrition of the rabbit. CABI,2010b:233-252
Gidenne T., Licois D.. Effect of a high fibre intake on the resistance of the growing rabbit to an experimental inoculation with an enteropathogenic strain of Escherichia coli..Anim. Sci.,2005c,(80):281-288
Gidenne T., Mirabito L., Jehl N., Perez J.M., Arveux P., Bourdillon A., Briens C., Duperray J. and Corrent E.. Impact of replacing starch by digestible fibre, at two levels of lignocellulose, on digestion, growth and digestive health of the rabbit. Animal Science,2004b,(78):389-398
Gidenne T., Perez J.M.. Apports de cellulose dans l'alimentation du lapin en croissance. I. Conse quences sur la digestion et le transit. Ann. Zootech,1996,(45):289-298
Gidenne T., Perez J.M.. Replacement of digestible fibre by starch in the diet of the growing rabbit. I. Effects on digestion, rate of passage and retention of nutrients. Ann. Zootech,2000,(49):357-368
Gidenne T., Pinheiro V., Falcao E., Cunha L.. A comprehensive approach of the rabbit digestion:consequences of a reduction in dietary fibre supply. Livest. Prod. Sci.,2000,(64):225-237
Gidenne T., Poncet C, Gomez L..Digestive transit of the components of fiber rich diets distributed at two feeding levels to adult rabbit females. Journees de la Recherche Cunicole en France, Paris (France),1986:10-11
Gidenne T., Segura M. and Lapanouse A.. Effect of cereal sources and processing in diets for the growing rabbits. I. Effects on digestion and fermentative activity in the caecum. Animal Research,2005a,(54):55-64
Gidenne T.. Caeco-colic digestion in the growing rabbit:impact of nutritional factors and related disturbances. Livest. Prod. Sci.,1997,(51):73-88
Gidenne T.. Effect of fibre level reduction and gluco-oligosaccharide addition on the growth performance and caecal fermentation in the growing rabbit. Animal Feed Science and Technology,1995,(56):253-263
Gidenne T.. Effect of fibre level, particle size and adaptation period on digestibility and rate of passage as measured at the ileum and in the faeces in the adult rabbit. Brit. J. Nutr,1992,(67):133-146
Gidenne T.. Estimation of volatile fatty acids and of their energetic supply in the rabbit caecum:effect of the dietary fibre level. In Proc.:VIeme Journees de la Recherche Cunicole,Paris6&7dec.,1994,(2):293-299
Gidenne T.. Evolution nycth6m6rale des produits de la fermentation bacterienne dans le tube digest if du lapin en croissance. Relations avec la teneur en lignines de la ration. Ann. Zootech.1986,(35):121-136
Gidenne T.. Fibres in rabbit feeding for digestive troubles prevention:Respective role of low-digested and digestible fibre. Livestock production science. Livest. Prod. Sci.,2003,(81):105-117
Gidenne T.Effect of fibre level reduction and Gluco-oligosaccharide addition on the growth performance and caecal fermentation in the growing rabbit.Anim.Feed Sci.Tech.,1995,(56):253-263
Goldman R.D., Khuon S., Chou Y.H., Opal V., Steinert P.M.. The function of intermediate filaments in cell shape and cytoskeletal integrity. J Cell Bio.,1996,(134):971-983
Gomez-Conde M.S., de Rozas A.P., Badiola I, Perez-Alba L., de Blas C, Carabano R., Garcia J.. Effect of neutral detergent soluble fibre on digestion, intestinal microbiota and performance in twenty five day old weaned rabbits. Livest. Sci.,2009,(125):192-198
Gomez-Conde M.S., Garcia J., Chamorro S., Eiras P., Rebollar P.G., Perez de Rozas A., Badiola I., De Blas C., Carabano R.. Neutral detergent-soluble fiber improves gut barrier function in twenty-five-day-old weaned rabbits. J. Anim. Sci.,2007,(85):3313-3321
Goodlad J. S., Mathers J. C.. Large bowel fermentation in rats given diets containing raw peas (Pisum sativum). British Journal of Nutrition,1990,(64):569-587
Goodlad J.S., Mathers J.C.. Large bowel fermentation in rats given diets containing raw peas. Br.J.Nutr,1990,(64):569-587
Gouet P., Fonty G.. Changes in the digestive microflora of holoxenic rabbits from birth until adullthood. Ann. Biol Anim. Bioch. Biophys.,1979,(19):553-566
Gouet P., Fonty G.. Evolution de la microflore digestive du lapin holoxenique de la naissance au sevrage. Ann. Bio.l anim. Biochim.Biophys.,1973,(13):733-735
Gregory M. S., Edwin A. D.. Role of the Gut in Multiple Organ Failure:Bacterial Translocation and Permeability Changes. World Journal of Surgery,1996,(20):411-417
Grinnell F.. Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol,2003,(13):264-269
Guarner F., Malagelada J.-R.. Gut flora in health and disease. The Lancet,2003,(361)512-519
Gutierrez A., Espinosa J., Garcia R., Caraban o, and J. C. De Blas. Effect of levels of starch, fiber, and lactose on digestion and growth performance of early-weaned rabbits. J. Anim. Sci.,2002,(80):1029-1037
Hanson N.B., Lanning D.K.. Microbial induction of B and T Cell areas in rabbit appendix. Dev. Comp. Immun.l,2008,(32):980-991
Haynes P.A., Gygi S.P., Figeys D., Aebersold R.. Proteome analysis:Biological assay or data archive? Electrophoresis,1998,(19):1862-1871
Helfand B.T., Chou Y.H., Shumaker D.K., Goldman R.D.. Intermediate filament proteins participate in signal transduction. Trends Cell Biol.,2005,(15):568-570
Hoover W.H. and Heitman R.N.. Effects of dietary fibre levels on weight gain,cecal volume and volatile fatty acid production in rabbits.JournalofNutrition,1972,(102):375-380
Huybens N., Houeix J., Licois D., Mainil J., Marlier D.. Pyrosequencing of epizootic rabbit enteropathy inocula and rabbit caecal samples. Vet. J.,2012, in press, doi:10.1016/j.bbr.2011.03.031
Ivaska J., Pallari H.M., Nevo J., Eriksson J.E.. Novel functions of vimentin in cell adhesion, migration, and signaling. Experimental Cell Res.,2007,(313):2050-2062
Jehl N., Gidenne T.. Replacement of starch by digestible fibre in feed for the growing rabbit.2. Consequences for microbial activity in the caecum and on incidence of digestive disorders. Anim. Feed Sci. Tech.,1996,(61):193-204
Jepson M. A., Clark M. A., Foster N., Mason C. M., Bennett M. K., Simmons N. L., Hirst B. H. Targeting to intestinal M cells. J. Anat,1996,(189):507-516
Jepson M. A., Clark M. A.. Studying M cells and their role in infection. Trends Microbio,1998,(6):359-365
Jepson M. A., Simmons N. L., O'Hagan D. T., Hirst B. H.. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J. Drug Target,1993,(1):245-249
Jepson M.A., Mason C.M., Bennett M.K., Simmons N.L., Hirst B.H.. Co-expression of vimentin and cytokeratins in M-cells of rabbit intestinal lymphoid follicle associated eptihelium. Histochem J,1992,(24):33-39
Jimenez E., Marin M.L., Martin R., Odriozola J.M., Olivares M., Xaus J., Fernandez L. Rodriguez J.M.. Is meconium from healthy newborns actually sterile? Res. Microbiol,2008,(159):187-193
Jin S., Song Y.C., Emili A., Sherman P.M. and Chan V.L.. J1pA of Campylobacter jejuni interacts with surface-exposed heat shock protein90alpha and triggers signalling pathways leading to the activation of NF-kappaB and p38MAP kinase in epithelial cells. Cell Microbiol,,2003,(5):165-174
Johnson R.J., Floege J., Yoshimura A., Iida H., Couser W.G., Alpers C.E.. The activated mesangial cell:a glomerular "myofibroblast"? J. Am. Soc. Nephrol.,1992,(2):190-197
Johnson R.J., Iida H., Alpers C.E., Majesky M.W., Schwartz S.M., Pritzl P., Gordon K. Gown A.M.. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation..J Clin. Invest.,1991,(87):847-858
J(?)rgensen R. B., Andersen L., Landbo and Mikkelsen T.. Spontaneous hybridization between oilseed rape(Brassica napus) and weedy relatives. Acta Horticulturae,1996(407)193-200
J(?)rgensen X., Zhao B.O., Eggum..The influence of dietary fibre and environmental temperature on the development of the gastrointestinal tract, digestibility, degree of fermentation in the hing-gut and energy metabolism in pigs.Br. J. Nutr.,1996,(75)365-378
Karlsson K.A.. Animal glycosphingolipids as membrane attachment sites for bacteria. Annu.Rev. Biochem.,1989,(58):309-350
Karolina A. Majorek, Przemyslaw J. Porebski, Arjun Dayal, Matthew D. Zimmerman, Kamila Jablonska, Alan J. Stewart, Maksymilian Chruszcz, Wladek Minor. Structural and immunologic characterization of bovine, horse, and rabbit serum albumins. Molecular Immunology,2012,(52):174-182
Kim G.B., Seo Y.M., Kim C.H., Paik I.K.. Effect of dietary prebiotic supplementation on the performance, intestinal microflora, and immune response of broilers. Poult. Sci.,2011,(90):75-82
Kimse M., Bayourthe C., Monteils V., Fortun-Lamothe L., Cauquil L., Combes S., Gidenne T.. Live yeast stability in rabbit digestive tract:Consequences on the caecal ecosystem, digestion, growth and digestive health. Anim. Feed Sri. Technol.,2012,(173):235-243
Koenig J.E., Spor A., Scalfone N., Fricker A.D., Stombaugh J., Knight R., Angenent L.T. Ley R.E.. Succession of microbial consortia in the developing infant gut microbiome. Proceedings of the National Academy of Sciences,2011,(108):4578-4585
Koikea J., Kobayashia T., Mukaib T., Watanabeb H., Suzukia M., Maruyamaa K., Higashic K..The activity of non-basal slip systems and dynamic recovery at room temperature in fine-grained AZ31B magnesium alloys.Acta Materialia,2003,(51):2055-2065
Kong Y., Teather R., Forster R.. Composition, spatial distribution, and diversity of the bacterial communities in the rumen of cows fed different forages. FEMS Microbiol. Ecol,2010,(74):612-622
Konkel M.E., Garvis S.G., Tipton S.L., Anderson D.E. Jr&Cieplak W. Jr Identification and molecular cloning of a gene encoding a fibronectin-binding protein (CadF) from Campylobacter jejuni. Mol. Microbio.l,1997,(24):953-963
Kovacs M., Szendro Z., Milisits G., Biro-Nemeth E., Radnai I., Posa R., Bonai A., Kovacs F., Horn P.. Effect of nursing method and faeces consumption on the development of bacetroides, lactobacillus and coliform flora in the caecum of the newborn rabbits. Reprod Nutr. Dev.,2006,(46):205-210
KozlowskiF..L'amidon,quell dosage pour quel echantillon?Cahiers Techniqued de Linra,1994,(35):5-22
Kraehenbuhl J. P., Neutra M. R.. Epithelial M cells:differentiation and function. Annu. Rev. Cell Dev. Biol.,2000,(16):301-332
Kuhn C., McDonald J.A.. The roles of the myofibroblasts in idiopathic pulmonary fibrosis. Ultrastructural and mmunohistochemical features of sites of active extracellular matrix synthesis. Am. J. Pathol,1991,(138):1257-1265
Kusar D., Avgustin G.. Molecular profiling and identification of methanogenic archaeal species from rabbit caecum. FEMS Microbiol. Ecol,2010,(74):623-630
Lackmann M., Rajasekariah P., Iismaa S.E.,Jones G., Cornish C.J.,Hu S., Simpson R.J.,Moritz R.L. and Geczy C.L.. Identification of a chemotactic domain of the pro-inflammatory S100protein CP-10. J.Immunol.,1993,(150):2981-2991
Lamendella R., VerBerkmoes N., Jansson J.K.."Omics" of the mammalian gut-new insights into function. Curr. Opin. Biotechnol,2012,(23):491-500
Lan R., Reeves P.R.. Escherichia coli in disguise:molecular origins of Shigella. Microbe. S. Infect.,2002,(4):1125-1132
Lanning D., Zhu X., Zhai S.-K., Knight K.L.. Development of the antibody repertoire in rabbit:gut-associated lymphoid tissue, microbes, and selection. Immunol. Rev.,2000,(175):214-228
Lee A. S.. Trends Biochem. Sci.1988,(12):20-23
Lelkes L., Chang C. Microbial dysbiosis in rabbit mucoid enteropathy. lab. Anim. Sci.,1987,(37):757-764
Lelouard H., Sahuquet A., Reggio H., Montcourrier P.. Rabbit M cells and dome enterocytes are distinct cell lineages. J. Cell Sci.,2001,(114):2077-2083
Ley R.E., Backhed F., Turnbaugh P., Lozupone C.A., Knight R.D., Gordon J.I.. Obesity alters gut microbial ecology.Proc. Natl. Acad. Sci. USA,2005,(102):11070-11075
Ley R.E., Turnbaugh P., Klein S., Gordon J.I.. Microbial ecology:human gut microbes associated with obesity. Nature,2006,(444):1022-1023
Li Z. and Srivastava P.K.. Tumor rejection antigen gp96/grp94is an ATPase:implications for protein folding and antigen presentation. EMBO J.,1993,(12):3143-3151
Lim B. O., K.Yamada, M. Nonaka, K. Yuichiro, P. Hung and M. Sugano. Dietary fiber modulates indices of intestinal immune function in rats. J. Nutr,1997,(127):663-667
Loubinoux J., Bronowicki J.P., Pereira I.A.C., Mougenel J.L., Faou A.E.L.. Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases. FEMS Microbiol Ecol,2002,(40):107-112
Mach J., Hshieh T., Hsieh D., Grubbs N., Chervonsky A.. Development of intestinal M cells. Immunol.Rev,2005,(206):177-189
Mage R.. Immunology of lagomorphs. In:Griebel, P., Pastoret, P.P., Bazin, H., Govaerts, A.(Eds.), Handbook of Vertebrate Immunology. Academic Press Iimited,1998:673
Mage R.G., Lanning D., Knight K.L., B cell and antibody repertoire development in rabbits: The requirement of gutassociated lymphoid tissues. Dev. Comp. Immunol,2006,(30)137-153
Maitre M.. A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties.JPET,1990,(255):657-663
Marlier D.,Dewree R.,Delleur V., Licois D., Lassence C., Poulipoulis A., Vindevogel H.. A review of the major causes of digestive disorders in the European rabbit.Annales de Medecine Veterinaire,2003,(147):385-392
Marounek M., Vovk S.J., Skrivanova V.. Distribution of activity of hydrolytic enzymes in the digestive tract of rabbits. Br. J. Nutr,1995,(73):463-469
Martin, T.A., Harrison, G., Mansel, R.E., and Jiang, W.G.. The role of the CD44/ezrin complex in cancer metastasis. Crit. Rev.Oncol. Hematol.,2003,(46):165-186
Marty J.and Vernay M.. Absorption and metabolism of the volatile fatty acids in the hind-gut of the rabbit.British Journal of Wutrition,1984,(52):265-277
Massip K., Combes S., Cauquil L., Zemb O., Gidenne T.. High throughput16S-DNA sequencing for phylogenetic affiliation of the caecal bacterial community in the rabbit-Impact of the hygiene of housing and of the intake level. In Proc.:Symposium on Gut Microbiology. Gut microbiota:friend or foe?,Clermont-Ferrand-France17-20June,2012
Mazmanian S.K., Liu C.H., Tzianabos A.O., Kasper D.L.. An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System. Cell,2005,(122):107-118
Mazzaferro E. M., Rudloff E., Kirby R.. The role of albumin replacement in the critically ill veterinary patient. J.Vet.Emerg. Crit. Care,2002(12):113-124
Meers P.,Mealy T..Calcium-dependent annexin V binding to phospholipids:stoichiometry, speciWcity, and the role of negative charge. Biochemistry,1993,(32):11711-11721
Mertens D.R.. Creating a System for Meeting the Fiber Requirements of Dairy Cows. Journal of Dairy Science,1997,(80):1463-1481
Meynell H. M., Thomas N. W., James P. S., Holland J., Taussig M. J., Nicoletti C Up-regulation of microsphere transport across the follicle-associated epithelium of Peyer's patch by exposure to Streptococcus pneumoniae R36a. FASEB J,1999,(13)611-619
Michelland R., Combes S., Monteils V., Cauquil L., Gidenne T., Fortun-Lamothe L.. Rapid adaptation of the bacterial community in the growing rabbit caecum after a change of dietary fibre supply. Animal,2011, in press
Michelland R.J., Combes S., Monteils V., Cauquil L., Gidenne T., Fortun-Lamothe L Molecular analysis of the bacterial community in digestive tract of rabbit. Anaerobe,2010,(16):61-65
Middelbos I.S., Vester Boler B.M., Qu A., White B.A., Swanson K.S.. Phylogenetic haracterization of Fecal Microbial Communities of Dogs Fed Diets with or without Supplemental Dietary Fiber Using454Pyrosequencing. Plos One,2010,(5):1-9
Mitsuoka T.. The human gastrointestinal tract. In:Wood BJB, editor. The Lactic Acid Bacteria. Vol.1. The Lactic Acid Bacteria in Health and Disease. London:Elsevier Applied Science,1992:69-114
Miyazawa K., Aso V., Kanaya T., Kido T., Minashima T., Watanabe K., Ohwada V., Kitazawa H., Rose M.T., Tahara K., Yamasaki T., Yamaguchi T.. Apoptotic process of porcine intestinal M cells. Cell Tissue Res,2006,(323):425-432.
Monica K., Oshima S., Anshu P. and Sujata G.. Identification of key proteins of cultured human intestinal cells involved in interaction with enteroaggregative Escherichia coli.2012,DOI:10.1111/j.1574-695X.2012.00998.x
Montagne L., Pluske J.R., Hampson D.J.. A review of interactions between dietary fibre and the intestinal mucosa, and their consequences on digestive health in young non-ruminant animals. Anim. Feed Sci.Technol,2003,(108):95-117
Monteils V., Cauquil L., Combes S., Godon J.-J., Gidenne T.. Potential core species and satellite species in the bacterial community within the rabbit caecum. FEMS Microbiol Ecol,2008,(66):620-629
Moore A.J., Moore P.J.. Female Strategy During Mate Choice:Threshold Assessment. Evolution,1988,(42):387-391
Moore M.N., Livingstone D.R. and Widdows J.. Hydrocarbons in marine molluscs:biological effects and ecological consequences. In Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment (edited by Varanasi V.),1988:291-328.
Moran E.T.. Starch digestion in fowl.Poult.Sri.,1982,(61):1257-1267
Morisse J. P., Boillietot E. and Maurice R.. Alimentation et modifications du milieu intestinal chez le lapin [J]. Recueil Medicine Veterinaire,1985,(161):443-449
Moser I, Schroeder W.&Salnikow J.. Campylobacter jejuni major outer membrane protein and a59-kDa protein are involved in binding to fibronectin and INT407cell membranes. FEMS Microbiol Lett,1997,(157):233-238
Miiller M., Kersten S.. Nutrigenomics:goals and strategies. Nat. Rev. Genet.,2003,(4):315-322
Muyzer G., De Waal E.C., Uitterlinden A.G.. Profiling of complex microbial Populationsby denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for16SrRNA.Appl.Environ.Mierobiol,1993,(59):695-700
Neutra M. R., Mantis N. J., Frey A., Giannasca P. J.. The composition and function of M cell apical membranes:implications for microbial pathogenesis. Semin. Immunol.,1999,(11):171-181
Neutra M.R.. M Cells in antigen sampling in mucosal tissue. Curr. Top. Microbial Immunol.,1999,(236):17-32
Nicodemus N., Garcia J. and De Blas J.C..Effect of inclusion of sunflower hulls in the diet on performance,disaccharidase activity in the small intestine and caecal traits of growing r abbits Animal science,2002,(75):237-243
Padilha M. T. S., Licois D., Gidenne T., Carre B. and Fonty G.. Relationships between microflora and caecal fermentation in rabbits before and after weaning. Reproduction Nutrition Development,1995,(35):375-386
Padilha M.T.S., Licois D., Coudert P.. Frequency of the carriage and enumeration of Escherichia coli in caecal content of15to49day old rabbits. In Proc.:6th World Rabbit Congress,Toulouse, France July09-12,1996,(3):99-102
Pappo J., Owen R.L.. Absence of secretory component expression by epithelial cells overlying rabbit gut-associated lymphoid tissue. Gastroenterology,1988,(95):1173-1177
Parigi-Bini R., Xiccato G. and Cinetto M.. Influenza del contenuto di amido alimentare sulla produttivita,sulla digeribilita e sulla composizione corporea di conigli in accrescimento. Zootecnica e Nutrizione Animale,1990,(16):271-282
Perez J.M., Gidenne T., Bouvarel I., Arveux P., Bourdillon A., Briens C, Le Naour J., Messager B., Mirabito L.. Apports de cellulose dans1'alimentation du lapin en croissance. Ⅱ. Conse quences sur les performances et la mortalite. Ann. Zootech.,1996,(45):299-309
Perez J.M., Gidenne T., Bouvarel I, Arveux P., Bourdillon A., Briens C., Le Naour J., Messager B., Mirabito L.. Replacement of digestible fibre by starch in the diet of the growing rabbit. II. Effects on performances and mortality by polysacdiarrhoea. Ann. Zootech.,2000,(49):369-377
Portsmouth J.I.. The nutrition of the rabbits.In:HaresignW., Swan H.and Lewis D.(eds) Nutriton and the Climatic Environment.Butterworths,London, UK,1977:93-111
Prasadarao N.V., Srivastava P.K., Rudrabhatla R.S., Kim K.S., Huang S.H.&Sukumaran S.K.. Cloning and expression of the Escherichia coli K1outer membrane protein A receptor, a gp96homologue. Infect. Immun.,2003,(71):1680-1688
Pupo G.M., Karaolis D.K.R., Lan R., Reeves P.R.. Evolutionary relationships among pathogenic and nonpathogenic Escherichia coli strains inferred from multilocus enzyme electrophoresis and mdh sequence studies. Infect. Immun,1997,(65):2685-2692
Quevedo F., Cervera C., Blas E., Baselga M. and Pascual J.J.. Long-term effect of selection for litter size and feeding programme on the performance of reproductive rabbit does1. Pregnancy of multiparous does. Animal Science,2006,(82):739-750
Rabbani G.H., Albert M.J., Rahman H., Islam M., Mahalanabis D., Kabir I., Alam K. and Ansaruzzaman M.. Development of an improved animal model of shigellosis in the adult rabbit by colonic infection with Shigella flexneri2a. Infect. Immun,199'5,(63)4350-4357
Rappsilber J., Ryder U., Lamond A.I. and Mann M..Large-Scale Proteomic Analysis of the Human Spliceosome. Genome Res.,2002,(12):1231-1245
Rautenberg K., Cichon C., Heyer G., Demel M., Schmidt M.A.. Immunohistochemical characterization of the follicle-associated epithelium of Peyer's patches:anti-cytokeratin8antibody (clone4.1.18) as a molecular marker for rat M cells. Eur. J. Cell Biol.,1996,(71):363-370
Raynal P., Pollard H.B.. Annexins:the problem of assessing the biological role for a gene family of multifunctional calcium-and phospholipid-binding proteins. Biochim. Biophys. Acta.,1994(1197):63-93
Rechner C., Kuhlewein C., Muller A., Schild H. and Rudel T.. Host glycoprotein Gp96and scavenger receptor SREC interact with PorB of disseminating Neisseria gonorrhoeae in an epithelial invasion pathway. Cell Host Microbe,2007,(2):393-403
Rhee K..-J., Sethupathi P., Driks A., Lanning D.K., Knight K.L.. Role of Commensal Bacteria in Development of Gut-Associated Lymphoid Tissues and Preimmune Antibody Repertoire. J Immunol,2004,(172):1118-1124
Rodriguez-Romero N., Abecia L., Balcells J., Martinez B., Fondevila M.. Comparison of bacterial profile from cecal content and caecotrophes in growing rabbits fed on two levels of indigestible fibre. In Proc.:ⅩⅩⅩⅨ Jornadas de Estudio, ⅩⅢ Jornadas sobre Production Animal, Zaragoza, Espana,12y13de mayo de2009:784-786
Sansonetti P. J., Arondel J., Cantey J. R., Prevost M. C., Huerre M.. Infection of rabbit Peyer's patches by Shigella flexneri:effect of adhesive or invasive bacterial phenotypes on follicle-associated epithelium. Infect. Immun,1996,(64):2752-2764
Sappino A.-P., Schurch W., Gabbiani G.. Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. lab. Invest.,1990,(63):144-161
Savidge T. C., Smith M. W., James P. S., Aldred P.. Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue. Am. J. Pathol.,1991,(139):177-184
Schroder J., Delmann W.E., Winlcler W.,Fandrich F., Schweizer E.,Schroeder P.. Glutamine dipeptide-supplemented parenteral nutrition reverses gut atrophy,disaccharidase enzyme activity,and absorption in rats. JPEN,1995,19(6):502-506.
Schweigert F.J.. Nutritional proteomics:methods and concepts for research in nutritional science. Ann. Nutr. Meta.b,2007,(51):99-107
Sci.USA,1983,(80):1579-1583
Severson K.M., Mallozzi M., Driks A., Knight K.L.. B Cell Development in GALT:Role of Bacterial Superantigen-Like Molecules. The Journal of Immunology,2010,(184):6782-6789
Shepherd M.L., Swecker W.S., Jensen R.V., Ponder M.A.. Characterization of the fecal bacteria communities of forage-fed horses by pyrosequencing of16S rRNA V4gene amplicons. FEMSMicrobiol Lett.,2012,(326):62-68
Sijpesteijn A.K.. On Ruminococcus flavefaciens, a cellulose-decomposing:bacterium from the rumen of sheep and cattle. J. Gen. Microbiol,1951,(5):869-879
Simecka J.W.. Mucosal immunity of the gastrointestinal tract and oral tolerance. Adv. Drug Deliv. Rev,1998,(34):235-259
Singh-Jasuja H.,Toes R.E.,Spee P.,Miinz C, Hilf N., Schoenberger S.P.,Ricciardi-Castagnoli P.,Neefjes J.,Rammensee H.G.,Arnold-Schild D.and Schild H..Crosspresentation of glycoprotein96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis. J. Exp. Med.,1999,(191):1965-1974
Skrivanova V., Copikova J., Sinica A., Marounek M.. Effects of a rabbit diet with sugar-beet pulp on gains, di gestibility of nutrients and quality of rabbit meat. Sci. Agric. Bohemica.,1996,(27):221-227
Soler M. D., Blas E., Cano J. L., Pascual J. J., Cervera C.,Fernandez-Carmona J.. Effect of digestible fiber/starch ratio animal fat level in diets around weaning on mortality rate of rabbits. Proceedings-8th World Rabbit Congress-September7-10,2004-Puebla, Mexico.
Soler M.D., Blas E., Biglia S., Casado C., Moya J. and Cervera C.. Digestibilidad ileal de piensos con distinto contenido en fibra digestible, almidon y grasa animal en gazapos en postdestete. In:Proceedings ⅩⅩⅪ Symposium de Cunicultura, lorca. ASESCU, Canet de Mar, Spain,2006:73-77
Suau A., Bonnet R., Sutren M., Godon J.-J., Gibson G.R., Collins M.D., Dore J.. Direct Analysis of Genes Encoding16S rRNA from Complex Communities Reveals Many Novel Molecular Species within the Human Gut. Appl. Environ. Microbiol.,1999,(65)4799-4807
Tajima K.,AminovR.I., Nagamine T., Matsui H., Nakamura M. and Benno Y. Diet-dependent shifts in the bacterial population of the rumen revealed with real-time PCR. Appl. Environ. Microbiol,2001,(67):2766-2774
Tao Z. Y. and Li F. C. Effects of dietary neutral detergent fibre on productionperformance, nutrient utilization, caecum fermentation and fibrolytic activity in2-to3-month-old New Zealand rabbits. Journal of Animal Physiology and Animal Nutrition,2006,(90):467-473
Tomasek J.J., Gabbiani G., Hinz B., Chaponnier C. and Brown R.A.. Myofi broblasts and mechano-regulation of connective tissue remodelling. Nat. Rev. Mol Cell Biol,2002,(3):349-363
Trowell H.. Ischemic heart disease and dietary fiber. Am. J. Clin. Nutr.,1972,(25):926-932
Turnbaugh P. J., Ley R.E., Mahowald M.A., Magrini V., Mardis E.R., Gordon J.I.. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature,2006,(444):1027-1031
Turnbaugh P.J., Hamady M., Yatsunenko T., Cantarel B.L., Duncan A., Ley R.E., Sogin M.L. Jones W.J., Roe B.A., Affourtit J.P., Egholm M., Henrissat B., Heath A.C., Knight R. and Gordon J.I.. A core gut microbiome in obese and lean twins. Nature,2008,(457):480-484
Tyrer P.C., Ruth Foxwell A., Kyd J.M., Otczyk D.C., Cripps A.W.. Receptor mediated targeting of M-cells. Vaccine,2007,(25):4204-3209
Vanhoutte T., Huys G., De Brandt E., Swings J.. Temporal stability analysis of the microbiota in human feces by denaturing gradient gel electrophoresis using universal and group specific16S rRNA primers. FEMS Microbiol. Ecol.,2004,(48):437-446
Weimer P.J.. Ruminal cellulolytic bacteria:physiology, ecology and beyond. In:USDA-ARS Proceedings of the Dairy Forage Research Center Conference with the Dairy and Forage Industries, Madison, WI.1996:53-60
Wielen P.W.J.J., Keuzenkamp D.A., Lipman L.J.A., Knapen F., Biesterveld S.. Spatial and Temporal Variation of the Intestinal Bacterial Community in Commercially Raised Broiler Chickens During Growth. Microbial Ecology,2002,(44):286-293
Wu S.G., Wang G.T., Angert E.R., Wang W.W., Li W.X., Zou H.. Composition, Diversity, and Origin of the Bacterial Community in Grass Carp Intestine. PLOS one,2012,(7):1-11
Xu K., Geczy C.L.. IFN-gamma and TNF regulat e macrophage expression of the chemotact ic S100prot ein S100A8. J. Immunol.,2000,(164):4916-4923
Xu R., Ho Y.S., Ritchie R.P., Li L.. Human SM22a BAC encompasses regulatory sequences for expression invascular and visceral smooth muscles at fetal and adult stages. Am. J. Heart Circ Physiol.,2003,(284):1398-1407
Yoo B.C., Vlkolinsky R., Engidawork E., Cairns N., Fountoulakis M., Lubec G.. Differential expression of molecular chaperones in brain of patients with Down syndrome. Electrophoresis,2001,(22):1233-1241
Yu B. and Chiou P. W. S.. Effects of crude fibre level in the diet on the intestinal morphology of growing rabbits. Lab. Anim,1996,(30):143-148
Yu B., Tsen H.Y.. Lactobacillus cells in the rabbit digestive tract and factors affecting their distribution. J Appl Bact,1993,(75):269-275
Zhao L., Zhao J., Wang S., Xia Y., Liu J., He J., Wang X.. Evaluation of immunocompatibility of tissue-engineered periosteum. Biomed. Mater.,2011,(6):1-8
Zhao X., J(?)rgensen H., Eggum B.O..The influence of dietary fibre on body composition, visceral organ weight, digestibility and energy balance in rats housed in different thermal environments. Br. J. Nutr.,1995,(73):687-699
Zoetendal E.G.,Akkermans A.D.L., De Vos W.M.. Temperature Gradient Gel Electrophoresis Analysis of16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria. Appl. Environ. Microbiol.,1998,(64):3854-3859
单永利.现代养兔.中国农业出版社出版,2004,150-151
董亚芳.家兔腹泻病主要病原及防治对策(上).中国养兔杂志,1992,(2)：3-5
高静华.两种不同来源颗粒料对幼兔生长影响的比较.上海畜牧兽医通讯,1995,(1)：31
金岭梅.日粮粗纤维水平对兔饲料转化率的影响.甘肃畜牧兽医,1994：6
李福昌.家兔营养.中国农业出版社,2009,11
卢德勋.饲粮纤维的营养作用及其利用.饲料营养研究进展(中国畜牧兽医学会动物营养学分会第三届饲料营养学术研讨会论文集).成都,亚洲中医药杂志社,1998,13-23
罗茜和曹伟新.白蛋白的临床应用及在营养治疗中的意义.中国临床营养杂志,2007,15(5)：315-318
秦应和,王俐,柯尊伟,等.家兔对不同品质粗纤维利用能力的研究.饲料研究,2000,(2)：5-7
唐良美,谢晓红,刘曼丽,李红.家兔饲料消化率测定方法的研究.中国养兔杂志,1991(2)：9-17
王兴春,杨致荣,王敏,李玮,李生才.高通量测序技术及其应用,中国生物工程杂志,2012,(32)：109-114
吴秋珏.饲粮中中性洗涤纤维的研究进展.饲料工业,2006,(27)：14-18
周秀菊,刘党生,蒋宇扬.肌酸激酶结构与功能研究进展.沈阳药科大学学报,2002,(19)：386-393
祝素珍,李福昌.2-3月龄肉兔日粮消化能水平对消化代谢和产肉性能影响的研究.动物营养学报.2004,16(4)：51-57
Abecia L., Fondevila M., Balcells J., Edwards J.E., Newbold C.J., McEwan N.R.. Molecular profiling of bacterial species in the rabbit caecum. FEMS Microbiol. Lett.,2005,(244):111-115
Abecia L., Fondevila M., Balcells J., Edwards J.E., Newbold C.J., McEwan N.R.. Effect of antibiotics on the bacterial population of the rabbit caecum. FEMS Microbiol. Lett.,2007a,(272):144-153
Abecia L., Fondevila M., Balcells J., Lobley G.E., McEwan N.R.. The effect of medicated diets and level of feeding on caecal microbiota of lactating rabbit does. J. Appl. Microbiol.,2007b,(103):787-793
Abecia L., Fondevila M., Balcells J., McEwan N.R.The effect of lactating rabbit does on the development of the caecal microbial community in the pups they nurture. J. Appl. Microbiol,2007c,(103):557-564
Aboul-Ela S.. Effect of dietary fiber and energy levels on performance of post. World Rabbit Science,2008,(Suppli):61
Abreu-Martin M.T., Targan S.R.. Regulation of immune responses of the intestinal mucosa. Crit. Rev. Immunol,1996,(16):227-309
Adjiri D., Bouillier Oudot M., Lebas F., Candau M.. Simulation in vitro des fermentations caecales du lapin en fermenteur a flux semi-continu.1. Role du pretraitement du substrat alimentaire. Reprod. Nutr. Dev.,1992,(32):351-360
Almendral J.M., Santaren J.F., Perera J., Zerial M., Bravo R..Expression, cloning and cDNA sequence of a fibroblast serumregulated gene encoding a putative actin-associated protein (p27). Exp. Cell Res,1989,(181):518-530
Alanen H. I., Williamson R. A., Howard M. J., Hatahet F.S., Salo K.E.H., Kauppila A.,Kellokumpu S. and Ruddock L.W.. ERp27, a new non-catalytic endoplasmic reticulum-locatedhuman protein disulfide isomerase family member,interacts with ERp57. J. Biol. Chem.,2006,(281):33727-33738.
Alpers C.E., Hudkins K.L., Gown A.M., Johnson R.J.. Enhanced expression of "muscle-specific" actin in glomerulonephritis. Kidney Int.,1992,(41):1134-1142
Alpers C.E., Pichler R., Johnson R.J.. Phenotypic features of cortical interstitial cells potentially important in fibrosis. Kidney Int.,1996,(49):S-28-31
Altieri D.C., Duperray A., Plescia J., Thornton G.B. and Languino L.R.. Structural Recognition of a Novel Fibrinogen Chain Sequence (117133) by Intercellular Adhesion Molecule-1Mediates Leukocyte-Endothelium Interaction. J. Biol. Chem.,1995,(2):696-699.
Appenzeller-Herzog C., Ellgaard L.. The human PDI family:Versatility packed into a single fold. Biochim. Biophys. Acta.,2008,(1783):535-548
Argenzio R. A..Physiology of diarrhea-large intestine. JAVMA,1978,(5):667-672
Arora P.D., N. Narani and C.A. McCulloch. The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fi broblasts. Am.J.Pathol,1999,(154):871-882
Asp N.G., Johansson C.G.. Dietary fibre analysis. Nutrition Abstract Review,1984,(54):735-752
Backhed F., Ding H., Wang T., Hooper L. V., Koh G. Y., Nagy A, Semenkovich C. F. and Gordon J.. The gut microbiota as an environmental factor that regulates fat storage. PNAS,2004,(101):15718-15723
Bennegadi N., Fonty G., Millet L., Gidenne T., Licois D.. Effects of age and dietary fibre level on caecal microbial communities of conventional and specific pathogen-free rabbits. Microbial Ecology in Health and Disease,2003,(5):23-32
Bennegadi N., Gidenne T., Licois L.. Impact of fibre deficiency and sanitary status on non-specific enteropathy of the growing rabbit. Anim. Res.,2001,(50):401-413
Bennegadi, N.. Non specific enteropathies in growing rabbit:Impacts of microbial and nutritional factors. PhD thesis, Institut National Polytechnique, Toulouse,2002:161
Beong O. L., Koji Y., Michiko N., Yuichiro K., Pham H. And Michihiro S.. Dietary Fibers Modulate Indices of Intestinal Immune Function in Rats. J. Nutr.,1997,(127):663-667
Blas E., Cervera C., Fernandez Carmona J.. Effect of two diets with varied starch and fibre levels on the performances of4-7weeks old rabbits. World Rabbit Sci.,1994,(2)117-121
Borghesi C., Taussig M. J., Nicoletti C.. Rapid appearance of M cells after microbial challenge is restricted at the periphery of the follicle-associated epithelium of Peyer's patch. Lab. Invest.,1999,(79):1393-1401
Boulahrouf A., Fonty G., Gouet P.. Establishment, counts and identification of the fibrolytic bacteria in the digestive tract of rabbit. Influence of feed cellulose content. Current microb.,1991,(22):1-25
Bosschaerts T., Guilliams M., Noel W., Herin M., Burk R.F., Hill K.E.,Brys L., RAES G., Ghassabeh G.H., Baetselier R.D. and Beschin A..Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10inducible gene selenoprotein P.J. Immunol.,2008,(180):6168-6175
Burk R.F., Hill K.E., Selenoprotein P-expression, functions, and roles in mai' nmals. Biochim. Biophys. Acta.,2009,(1790):1441-1447
Cabanes D., Sousa S., Cebria A., Lecuit M., Garcia-del Portillo F.&Cossart P.. Gp96is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein. EMBO J.,2005,(24):2827-2838
Carabano R., Badiola I., Chamorro S., Garcia J., Garcia-Ruiz A.I., Garcia-Rebollar P. Gomez-Conde M. S., Gutierrez I., Nicodemus N., Villamide M. J., De Blas J. C..New trends in rabbit feeding:influence of nutrition on intestinal health. Span. J. Agric. Res.(Special issue J. M. Malpica),2008,(6):15-25
Carabano R., Garcia J., De Blas J.C.. Effect of fibre source on ileal apparent digestibility of non-starch polysaccharides in rabbits. Anim. Sci.,2001,(72):343-350
Carpita N.C., Gibeaut D.M.. Structural models of primary cell walls in flowering plants: consistency of molecular structure with the physical properties of the walls during growth. Plant J.,1993,(3):1-30
Carpita N.C.. Structure and biogenesis of the cell walls of grasses. Annual Review of Plant Physiology and Plant Molecular Biology,1996,(47):445-476
Chamorro S., Gomez-Conde M.S., Perez de Rozas A.M., Carabano R., De Blas J.C.. Effect on digestion andperfomance of dietary protein content and of increased substitution of lucerne hay with soya-bean protein concentrate in starter diets fo young rabbits. Animal,2007,(1):651-659
Chao G.T.,O'Leary-Kelly A.M.,Wolf S..Organizational socialization:its content and consequences.JAP,1994,(79):730-743
Chao H.Y., Li F.C.. Effect of level of fibre on performance and digestion traits in growing rabbits. Animal Feed Science and Technology,2008,(144):279-291
Cheeke P.R., Patton N.M., Carbohydrate overload of the hindgut. A probable cause of enteritis. J. Appl. Rabbit Res.,1980,(3):20-23
Cheeke PR..Rabbit feeding and nutrition. Academic Press,USA,1987
Chesson A.. Dietary fiber. In:Stephen, A.M.(Ed.), Food polysaccharides and their applications. Marcel Dekker, New York,1995:547-576
Chiou P.W.S., Yu B., Lin C.. Effect of different components of dietary fibre on the intestinal morphology of domestic rabbits. Comp. Biochem. Physiol. A,1994,(108):629-638
Clark M. A., Hirst B. H., Jepson M. A.. Lectin-mediated mucosal delivery of drugs and microparticles. Adv. Drug Deliv. Rev.,2000,(43):207-223
Clark M.A., Jepson M.A., Hirst B.H.. Exploiting M cells for drug and vaccine delivery. Adv. Drug Deliv. Rev,2001,(50):81-106
Clark M.A., Jepson M.A., Simmons N.L., Booth T.A., Hirst B.H.. Differential expression of lectin-binding sites defines mouse intestinal M-cells. J. Histochem. Cytochem.,1993,(41):1679-1687
Clark M.A., Jepson M.A.. Intestinal M cells and their role in bacterial infection. Int. J. Med. Microbiol.,2003,(293):17-39
Combes S., Fortun-Lamothe L., Cauquil L., Gidenne T.. Controlling the rabbit digestive ecosystem to improve digestive health and efficacy. Proceedings10th World Rabbit Congress September3-6,2012-Sharm El-Sheikh-Egypt,2012:475-494
Combes S., Michelland R.J., Monteils V., Cauquil L., Soulie V., Tran N.U., Gidenne T. Fortun-Lamothe L.. Postnatal development of the rabbit caecal microbiota composition and activity. FEMS Microbiol. Ecol,2011,(77):680-689
Corthier G.. Bonnes bacteries et bonne sante.Quae ed.Versailles,2011,(2):128
Coudert P., Licois D. and Besnard J.. Establishment of a specified pathogen free breeding colony (SPF) without hysterectomy and hand-rearing procedures. In:Proc.4th Congress of the World Rabbit Science Assoc.,10-14October,1988:137-148
Cummings J.H.. Short chain fatty acids in the human colon.Gut.,1981,(22):763-779
Daly K., Stewart C.S., Flint H.J., Shirazi-Beechey S.P.. Bacterial diversity within the equine large intestine as revealed by molecular analysis of cloned16S rRNA genes. FEMS Microbiol. Ecol,2001,(38):141-151
Danninger C., Gimona M.. Live dynamics of GFP-calponin:Isoform-specific modulation of the actincytoskeleton and autoregulation by C-terminal sequences. J. Cell Sci.,2000,(113):3725-3736
De Arruda A.M.V., Lopes D.C., Ferreira W.M., Rostagno H.S., Queiroz A.C., Pereira E.S., Albino L.F.T. and Da Silva J.F.. Digestibilidade aparente dos nutrientes de racoes contendo diferentes fontes de fibra e niveis de amido com coelhos em crescimento. Revista Brasileira de Zootecnia,2002,(31):1166-1175
De Blas C, Mateos G.G.. Feed formulation In:De Blas C., Wiseman J.J.(Eds).The nutrition of the rabbit. New York:CABI Publishing,1998:241-253
De Blas J.C., Santoma G.,Carabno R.and Fraga M. J.. Fiber and starch levels in fattening rabbit diets.Journal of Animal Science,1986,(63):1897-1904
De Vries J.W., Prosky L., Li B., Cho S.. A historical perspective on defining dietary fiber. Cereal Foods World,1999,(44):367-369
Didierlaurent A., Sirard J. C, Kraehenbuhl J. P., Neutra M. R.. How the gut senses its content. Cell. Microbiol,2002,(4):61-72
Dorsey C.W., Laarakker M.C., Humphries A.D., Weening E.H.&Baumler A.J.. Salmonella enterica serotype Typhimurium MisL is an intestinal colonization factor that binds fibronectin. Mol Microbiol,2005,(57):196-211
Dowd S.E., Callaway T.R., Wolcott R.D., Sun Y., McKeehan T., Hagevoort R.G and Edrington T.S.. Evaluation of the bacterial diversity in the feces of cattle using16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP).BMC Microbiology,2008,(8):125
Doweiko J.P., Nompleggi D.J.. Role of albumin in human physiology and pathophysiology.J. Parent Ent. Nutr.,1991,15(2):207-211
Eliasson A.C. and Gudmundsson M.. Starch:physicochemical and functional aspects.In: Eliasson,A.C.(Ed) Carbohydrates in Food. Marcel Dekker Inc, Basel,Switzerlan,1996:431-503
Ellgaard L.,Ruddock L. W.. The human protein disulphide isomerase family:substrate interactions andfunctional properties. EMBO Rep.,2005,(6):28-32
Ermak T. H., Giannasca P. J.. Microparticle targeting to M cells. Adv. Drug Deliv. Rev.,1998,(34):261-283
Ermak T.H., Bhagat H.R., Pappo J.. Lymphocyte compartments in antigen-sampling regions of rabbit mucosal lymphoid organs. Am. J. Trop. Med. Hyg.,1994,(50):14-28 Evolution,1988,(42):387-391FAOSTAT,2011
Farfan M.J., Inman K.G.&Nataro J.P.. The major pilin subunit of the AAF/II fimbriae from enteroaggregative Escherichia coli mediates binding to extracellular matrix proteins. Infect Immun.,2008,(76):4378-4384
Feyzullah Beyaz E., Erggun A. G., Bayraktaroglu L., Ergun. The identification of intestinal M cells in the sacculus rotundus and appendix of the Angora rabbit. Vet. Res. Commun.,2010,(34):255-265
Field C.J., McBurneya M.I., Massiminob S., Hayekb M.G., and Sunvold G.D.. The fermentable fiber content of the diet alters the function and composition of canine gut associated lymphoid tissue. Vet. Immunol. Immunopathol.,1999,(72):325-341
Fischer S.G., Lerman L.S..DNA fragmentdiffering by single basepair substitutions are separated in denaturing gradientgels:correspondencewithmelting theory.Proc. Natl.Acad.
Fonty G., Gouet P., Riou Y.. Effect of milk composition on the gastrointestinal microflora of the rabbit. Ann Biol Anim. Bioch. Biophys,1979,(19):567-571
Fonty G., Gouet P..Fibre-degradating microorganisms in the monogastric digestive trac. Anim. Feed Sci. Technol.,1989,(23):91-107
Forsythe S.J., Parker D.S.. Nitrogen metabolism by the microbial flora of the rabbit. J. Appl. Bacteriology.,1985,(58):363-369
Fu Y.P., Liu H.W., Forsythe S.M., Kogut P., McConville J.F., Halayko A.J., Camoretti-Mercado B. and Solway J.,. Mutagenesis analysis of human SM22: characterization of actin binding. J. Appl. Physiol.,2000,(89):1985-1990
Gallois M., Fortun-Lamothe L., Michelan A. and Gidenne T.. Adaptability of the digestive function according to age at weaning in the rabbit:Ⅱ. Effect on nutrient digestion in the small intestine and in the whole digestive tract. Animal,2008,(2):536-547
Garcia J., Carabano R., De Blas J. C. Effect of fibre source on cell wall digestibility and rate of passage in rabbits. Animal Sciecne,1999,(77):898-905
Garcia J., Carabano R., Perez-Alba L., De Blas J.C.. Effect of fiber source on cecal fermentation and nitrogenrecycled through cecotrophy in rabbits. J. Anim. Sci.,2000,(78):638-646
Garcia J., Gidenne T., Falcao-e-Cunha L. and de Blas C.. Identification of the main factors that influence caecal fermentation traits in growing rabbits. Animal Research,2002,(51):165-173
Gebert A., Hach G., Bartels H.. Co-localization of vimentin and cytokeratins in M-cells of rabbit gutassociated lymphoid tissue (GALT). Cell Tissue Res.,1992,(269):331-340
Gebert A., Pabst R.. M cells at locations outside the gut. Semin. Immunl,1999,(11):165-170
Gebert A., Posselt W.. Glycoconjugate expression defines the origin and differentiation pathway of intestinal M-cells. J. Histochem. Cytochem.,1997,(45):1341-1350
Gebert A., Rothkotter H. J., Pabst R.. M cells in Peyer's patches of the intestine. Int. Rev. Cytol.,1996,(167):91-159
Gebert A., Steinmetz I., Fassbender S., Wendlandt K.H.. Antigen transport into Peyer's patches:Increased uptake by constant numbers of M cells. Am. J. PathoL.,2004,(164):65-72
Gibson G., Roberfroid M.. Dietary modulation of the human colonic microbiota:introducing the concept of prebiotics. J. Nutr.,1995,(125):1401-1412
Giddene T., Garcia J.. Nutritional strategies improving the digestive health of he weaned rabbits. In:Maertens L,Coudert P, editors. Recent Advances in rabbit sciences. ILVO, Merelbeke, Belgium,2006:229-238
Gidenne T., Arveux P., Madec O.. The effect of the quality of dietary lignocellulose on digestion, zootechnical performance and health of the growing rabbit. Anim. Sci.,2001,(73):97-104
Gidenne T., Bellier R., Van Eys J.. Effect of the dietary fibre origin on the digestion and on the caecal fermentation pattern of the growing rabbit. Anim. Sci.,1998,(66):509-517
Gidenne T., Bellier R.. Use of digestible fibre in replacement to available carbihydrates-Effect on digestion, rate of passage and caecal fermentation pattern during the growth of the rabbit. Livest. Prod. Sci.,2000,(63):141-152
Gidenne T., Combes S., Licois D., Carabano R., Badiola I., Garcia J.. Ecosysteme caecal et nutrition du lapin:interactions avec la sante digestive. INRA Prod. Anim.,2008,(21):239-250
Gidenne T., Debray L., Fortun-Lamothe L., Le Huerou-Luronz I..Maturation of the intestinal digestion and of microbial activity in the young rabbit:Impact of the dietary fibre:starch ratio. Comparative Biochemistry and Physiology, Part A,2007,(148):834-844
Gidenne T., Garcia J., Lebas F., Licois D.. Nutrition and feeding strategy:interactions with pathology. In:De Blas C, Wiseman J,editors. CABI:Nutrition of the rabbit.,2010a179-199
Gidenne T., Jehl N., Lapanouse A., Segura M.. Inter-relationship of microbial activity, digestion and gut health in the rabbit:effect of substituting fibre by starch in diets having a high proportion of rapidly fermentable polysaccharides. Brit. J. Nutr.,2004a,(92)95-104
Gidenne T., Jehl N., Perez J.M., Arveux P., Bourdillon A., Mousset J.L., Duperray J., Stephan S. and Lamboley B.. Effect of cereal sources and processing in diets for the growing rabbits. Ⅱ. Effects on performance and mortality by enteropathy. Animal Research,2005b,(54):65-72
Gidenne T., Jehl N., Segura M., Michalet-Doreau B.. Microbial activity in the caecum of the rabbit around weaning:impact of a dietary fibre deficiency and of intake level. Animal Feed Science and Technology,2002,(99):107-118
Gidenne T., Jehl N.. Re'ponse zootechnique du lapin en croissance face aune reduction de l'apport de fibres, dans des re'gimes riches en fibres digestibles. In:Perez, J.M.(Ed.),8e me J.Rech Cunicoles Fr.,9-10June. ITAVI, Paris,1999:109-113
Gidenne T., Lebas F., Fortun-Lamothe L.. Feeding behaviour of rabbits. In:De Blas, C., Wiseman, J.(Ed.), Nutrition of the rabbit. CABI,2010b:233-252
Gidenne T., Licois D.. Effect of a high fibre intake on the resistance of the growing rabbit to an experimental inoculation with an enteropathogenic strain of Escherichia coli..Anim. Sci.,2005c,(80):281-288
Gidenne T., Mirabito L., Jehl N., Perez J.M., Arveux P., Bourdillon A., Briens C., Duperray J. and Corrent E.. Impact of replacing starch by digestible fibre, at two levels of lignocellulose, on digestion, growth and digestive health of the rabbit. Animal Science,2004b,(78):389-398
Gidenne T., Perez J.M.. Apports de cellulose dans l'alimentation du lapin en croissance. I. Conse quences sur la digestion et le transit. Ann. Zootech,1996,(45):289-298
Gidenne T., Perez J.M.. Replacement of digestible fibre by starch in the diet of the growing rabbit. I. Effects on digestion, rate of passage and retention of nutrients. Ann. Zootech,2000,(49):357-368
Gidenne T., Pinheiro V., Falcao E., Cunha L.. A comprehensive approach of the rabbit digestion:consequences of a reduction in dietary fibre supply. Livest. Prod. Sci.,2000,(64):225-237
Gidenne T., Poncet C, Gomez L..Digestive transit of the components of fiber rich diets distributed at two feeding levels to adult rabbit females. Journees de la Recherche Cunicole en France, Paris (France),1986:10-11
Gidenne T., Segura M. and Lapanouse A.. Effect of cereal sources and processing in diets for the growing rabbits. I. Effects on digestion and fermentative activity in the caecum. Animal Research,2005a,(54):55-64
Gidenne T.. Caeco-colic digestion in the growing rabbit:impact of nutritional factors and related disturbances. Livest. Prod. Sci.,1997,(51):73-88
Gidenne T.. Effect of fibre level reduction and gluco-oligosaccharide addition on the growth performance and caecal fermentation in the growing rabbit. Animal Feed Science and Technology,1995,(56):253-263
Gidenne T.. Effect of fibre level, particle size and adaptation period on digestibility and rate of passage as measured at the ileum and in the faeces in the adult rabbit. Brit. J. Nutr,1992,(67):133-146
Gidenne T.. Estimation of volatile fatty acids and of their energetic supply in the rabbit caecum:effect of the dietary fibre level. In Proc.:VIeme Journees de la Recherche Cunicole,Paris6&7dec.,1994,(2):293-299
Gidenne T.. Evolution nycth6m6rale des produits de la fermentation bacterienne dans le tube digest if du lapin en croissance. Relations avec la teneur en lignines de la ration. Ann. Zootech.1986,(35):121-136
Gidenne T.. Fibres in rabbit feeding for digestive troubles prevention:Respective role of low-digested and digestible fibre. Livestock production science. Livest. Prod. Sci.,2003,(81):105-117
Gidenne T.Effect of fibre level reduction and Gluco-oligosaccharide addition on the growth performance and caecal fermentation in the growing rabbit.Anim.Feed Sci.Tech.,1995,(56):253-263
Goldman R.D., Khuon S., Chou Y.H., Opal V., Steinert P.M.. The function of intermediate filaments in cell shape and cytoskeletal integrity. J Cell Bio.,1996,(134):971-983
Gomez-Conde M.S., de Rozas A.P., Badiola I, Perez-Alba L., de Blas C, Carabano R., Garcia J.. Effect of neutral detergent soluble fibre on digestion, intestinal microbiota and performance in twenty five day old weaned rabbits. Livest. Sci.,2009,(125):192-198
Gomez-Conde M.S., Garcia J., Chamorro S., Eiras P., Rebollar P.G., Perez de Rozas A., Badiola I., De Blas C., Carabano R.. Neutral detergent-soluble fiber improves gut barrier function in twenty-five-day-old weaned rabbits. J. Anim. Sci.,2007,(85):3313-3321
Goodlad J. S., Mathers J. C.. Large bowel fermentation in rats given diets containing raw peas (Pisum sativum). British Journal of Nutrition,1990,(64):569-587
Goodlad J.S., Mathers J.C.. Large bowel fermentation in rats given diets containing raw peas. Br.J.Nutr,1990,(64):569-587
Gouet P., Fonty G.. Changes in the digestive microflora of holoxenic rabbits from birth until adullthood. Ann. Biol Anim. Bioch. Biophys.,1979,(19):553-566
Gouet P., Fonty G.. Evolution de la microflore digestive du lapin holoxenique de la naissance au sevrage. Ann. Bio.l anim. Biochim.Biophys.,1973,(13):733-735
Gregory M. S., Edwin A. D.. Role of the Gut in Multiple Organ Failure:Bacterial Translocation and Permeability Changes. World Journal of Surgery,1996,(20):411-417
Grinnell F.. Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol,2003,(13):264-269
Guarner F., Malagelada J.-R.. Gut flora in health and disease. The Lancet,2003,(361)512-519
Gutierrez A., Espinosa J., Garcia R., Caraban o, and J. C. De Blas. Effect of levels of starch, fiber, and lactose on digestion and growth performance of early-weaned rabbits. J. Anim. Sci.,2002,(80):1029-1037
Hanson N.B., Lanning D.K.. Microbial induction of B and T Cell areas in rabbit appendix. Dev. Comp. Immun.l,2008,(32):980-991
Haynes P.A., Gygi S.P., Figeys D., Aebersold R.. Proteome analysis:Biological assay or data archive? Electrophoresis,1998,(19):1862-1871
Helfand B.T., Chou Y.H., Shumaker D.K., Goldman R.D.. Intermediate filament proteins participate in signal transduction. Trends Cell Biol.,2005,(15):568-570
Hoover W.H. and Heitman R.N.. Effects of dietary fibre levels on weight gain,cecal volume and volatile fatty acid production in rabbits.JournalofNutrition,1972,(102):375-380
Huybens N., Houeix J., Licois D., Mainil J., Marlier D.. Pyrosequencing of epizootic rabbit enteropathy inocula and rabbit caecal samples. Vet. J.,2012, in press, doi:10.1016/j.bbr.2011.03.031
Ivaska J., Pallari H.M., Nevo J., Eriksson J.E.. Novel functions of vimentin in cell adhesion, migration, and signaling. Experimental Cell Res.,2007,(313):2050-2062
Jehl N., Gidenne T.. Replacement of starch by digestible fibre in feed for the growing rabbit.2. Consequences for microbial activity in the caecum and on incidence of digestive disorders. Anim. Feed Sci. Tech.,1996,(61):193-204
Jepson M. A., Clark M. A., Foster N., Mason C. M., Bennett M. K., Simmons N. L., Hirst B. H. Targeting to intestinal M cells. J. Anat,1996,(189):507-516
Jepson M. A., Clark M. A.. Studying M cells and their role in infection. Trends Microbio,1998,(6):359-365
Jepson M. A., Simmons N. L., O'Hagan D. T., Hirst B. H.. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J. Drug Target,1993,(1):245-249
Jepson M.A., Mason C.M., Bennett M.K., Simmons N.L., Hirst B.H.. Co-expression of vimentin and cytokeratins in M-cells of rabbit intestinal lymphoid follicle associated eptihelium. Histochem J,1992,(24):33-39
Jimenez E., Marin M.L., Martin R., Odriozola J.M., Olivares M., Xaus J., Fernandez L. Rodriguez J.M.. Is meconium from healthy newborns actually sterile? Res. Microbiol,2008,(159):187-193
Jin S., Song Y.C., Emili A., Sherman P.M. and Chan V.L.. J1pA of Campylobacter jejuni interacts with surface-exposed heat shock protein90alpha and triggers signalling pathways leading to the activation of NF-kappaB and p38MAP kinase in epithelial cells. Cell Microbiol,,2003,(5):165-174
Johnson R.J., Floege J., Yoshimura A., Iida H., Couser W.G., Alpers C.E.. The activated mesangial cell:a glomerular "myofibroblast"? J. Am. Soc. Nephrol.,1992,(2):190-197
Johnson R.J., Iida H., Alpers C.E., Majesky M.W., Schwartz S.M., Pritzl P., Gordon K. Gown A.M.. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation..J Clin. Invest.,1991,(87):847-858
J(?)rgensen R. B., Andersen L., Landbo and Mikkelsen T.. Spontaneous hybridization between oilseed rape(Brassica napus) and weedy relatives. Acta Horticulturae,1996(407)193-200
J(?)rgensen X., Zhao B.O., Eggum..The influence of dietary fibre and environmental temperature on the development of the gastrointestinal tract, digestibility, degree of fermentation in the hing-gut and energy metabolism in pigs.Br. J. Nutr.,1996,(75)365-378
Karlsson K.A.. Animal glycosphingolipids as membrane attachment sites for bacteria. Annu.Rev. Biochem.,1989,(58):309-350
Karolina A. Majorek, Przemyslaw J. Porebski, Arjun Dayal, Matthew D. Zimmerman, Kamila Jablonska, Alan J. Stewart, Maksymilian Chruszcz, Wladek Minor. Structural and immunologic characterization of bovine, horse, and rabbit serum albumins. Molecular Immunology,2012,(52):174-182
Kim G.B., Seo Y.M., Kim C.H., Paik I.K.. Effect of dietary prebiotic supplementation on the performance, intestinal microflora, and immune response of broilers. Poult. Sci.,2011,(90):75-82
Kimse M., Bayourthe C., Monteils V., Fortun-Lamothe L., Cauquil L., Combes S., Gidenne T.. Live yeast stability in rabbit digestive tract:Consequences on the caecal ecosystem, digestion, growth and digestive health. Anim. Feed Sri. Technol.,2012,(173):235-243
Koenig J.E., Spor A., Scalfone N., Fricker A.D., Stombaugh J., Knight R., Angenent L.T. Ley R.E.. Succession of microbial consortia in the developing infant gut microbiome. Proceedings of the National Academy of Sciences,2011,(108):4578-4585
Koikea J., Kobayashia T., Mukaib T., Watanabeb H., Suzukia M., Maruyamaa K., Higashic K..The activity of non-basal slip systems and dynamic recovery at room temperature in fine-grained AZ31B magnesium alloys.Acta Materialia,2003,(51):2055-2065
Kong Y., Teather R., Forster R.. Composition, spatial distribution, and diversity of the bacterial communities in the rumen of cows fed different forages. FEMS Microbiol. Ecol,2010,(74):612-622
Konkel M.E., Garvis S.G., Tipton S.L., Anderson D.E. Jr&Cieplak W. Jr Identification and molecular cloning of a gene encoding a fibronectin-binding protein (CadF) from Campylobacter jejuni. Mol. Microbio.l,1997,(24):953-963
Kovacs M., Szendro Z., Milisits G., Biro-Nemeth E., Radnai I., Posa R., Bonai A., Kovacs F., Horn P.. Effect of nursing method and faeces consumption on the development of bacetroides, lactobacillus and coliform flora in the caecum of the newborn rabbits. Reprod Nutr. Dev.,2006,(46):205-210
KozlowskiF..L'amidon,quell dosage pour quel echantillon?Cahiers Techniqued de Linra,1994,(35):5-22
Kraehenbuhl J. P., Neutra M. R.. Epithelial M cells:differentiation and function. Annu. Rev. Cell Dev. Biol.,2000,(16):301-332
Kuhn C., McDonald J.A.. The roles of the myofibroblasts in idiopathic pulmonary fibrosis. Ultrastructural and mmunohistochemical features of sites of active extracellular matrix synthesis. Am. J. Pathol,1991,(138):1257-1265
Kusar D., Avgustin G.. Molecular profiling and identification of methanogenic archaeal species from rabbit caecum. FEMS Microbiol. Ecol,2010,(74):623-630
Lackmann M., Rajasekariah P., Iismaa S.E.,Jones G., Cornish C.J.,Hu S., Simpson R.J.,Moritz R.L. and Geczy C.L.. Identification of a chemotactic domain of the pro-inflammatory S100protein CP-10. J.Immunol.,1993,(150):2981-2991
Lamendella R., VerBerkmoes N., Jansson J.K.."Omics" of the mammalian gut-new insights into function. Curr. Opin. Biotechnol,2012,(23):491-500
Lan R., Reeves P.R.. Escherichia coli in disguise:molecular origins of Shigella. Microbe. S. Infect.,2002,(4):1125-1132
Lanning D., Zhu X., Zhai S.-K., Knight K.L.. Development of the antibody repertoire in rabbit:gut-associated lymphoid tissue, microbes, and selection. Immunol. Rev.,2000,(175):214-228
Lee A. S.. Trends Biochem. Sci.1988,(12):20-23
Lelkes L., Chang C. Microbial dysbiosis in rabbit mucoid enteropathy. lab. Anim. Sci.,1987,(37):757-764
Lelouard H., Sahuquet A., Reggio H., Montcourrier P.. Rabbit M cells and dome enterocytes are distinct cell lineages. J. Cell Sci.,2001,(114):2077-2083
Ley R.E., Backhed F., Turnbaugh P., Lozupone C.A., Knight R.D., Gordon J.I.. Obesity alters gut microbial ecology.Proc. Natl. Acad. Sci. USA,2005,(102):11070-11075
Ley R.E., Turnbaugh P., Klein S., Gordon J.I.. Microbial ecology:human gut microbes associated with obesity. Nature,2006,(444):1022-1023
Li Z. and Srivastava P.K.. Tumor rejection antigen gp96/grp94is an ATPase:implications for protein folding and antigen presentation. EMBO J.,1993,(12):3143-3151
Lim B. O., K.Yamada, M. Nonaka, K. Yuichiro, P. Hung and M. Sugano. Dietary fiber modulates indices of intestinal immune function in rats. J. Nutr,1997,(127):663-667
Loubinoux J., Bronowicki J.P., Pereira I.A.C., Mougenel J.L., Faou A.E.L.. Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases. FEMS Microbiol Ecol,2002,(40):107-112
Mach J., Hshieh T., Hsieh D., Grubbs N., Chervonsky A.. Development of intestinal M cells. Immunol.Rev,2005,(206):177-189
Mage R.. Immunology of lagomorphs. In:Griebel, P., Pastoret, P.P., Bazin, H., Govaerts, A.(Eds.), Handbook of Vertebrate Immunology. Academic Press Iimited,1998:673
Mage R.G., Lanning D., Knight K.L., B cell and antibody repertoire development in rabbits: The requirement of gutassociated lymphoid tissues. Dev. Comp. Immunol,2006,(30)137-153
Maitre M.. A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties.JPET,1990,(255):657-663
Marlier D.,Dewree R.,Delleur V., Licois D., Lassence C., Poulipoulis A., Vindevogel H.. A review of the major causes of digestive disorders in the European rabbit.Annales de Medecine Veterinaire,2003,(147):385-392
Marounek M., Vovk S.J., Skrivanova V.. Distribution of activity of hydrolytic enzymes in the digestive tract of rabbits. Br. J. Nutr,1995,(73):463-469
Martin, T.A., Harrison, G., Mansel, R.E., and Jiang, W.G.. The role of the CD44/ezrin complex in cancer metastasis. Crit. Rev.Oncol. Hematol.,2003,(46):165-186
Marty J.and Vernay M.. Absorption and metabolism of the volatile fatty acids in the hind-gut of the rabbit.British Journal of Wutrition,1984,(52):265-277
Massip K., Combes S., Cauquil L., Zemb O., Gidenne T.. High throughput16S-DNA sequencing for phylogenetic affiliation of the caecal bacterial community in the rabbit-Impact of the hygiene of housing and of the intake level. In Proc.:Symposium on Gut Microbiology. Gut microbiota:friend or foe?,Clermont-Ferrand-France17-20June,2012
Mazmanian S.K., Liu C.H., Tzianabos A.O., Kasper D.L.. An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System. Cell,2005,(122):107-118
Mazzaferro E. M., Rudloff E., Kirby R.. The role of albumin replacement in the critically ill veterinary patient. J.Vet.Emerg. Crit. Care,2002(12):113-124
Meers P.,Mealy T..Calcium-dependent annexin V binding to phospholipids:stoichiometry, speciWcity, and the role of negative charge. Biochemistry,1993,(32):11711-11721
Mertens D.R.. Creating a System for Meeting the Fiber Requirements of Dairy Cows. Journal of Dairy Science,1997,(80):1463-1481
Meynell H. M., Thomas N. W., James P. S., Holland J., Taussig M. J., Nicoletti C Up-regulation of microsphere transport across the follicle-associated epithelium of Peyer's patch by exposure to Streptococcus pneumoniae R36a. FASEB J,1999,(13)611-619
Michelland R., Combes S., Monteils V., Cauquil L., Gidenne T., Fortun-Lamothe L.. Rapid adaptation of the bacterial community in the growing rabbit caecum after a change of dietary fibre supply. Animal,2011, in press
Michelland R.J., Combes S., Monteils V., Cauquil L., Gidenne T., Fortun-Lamothe L Molecular analysis of the bacterial community in digestive tract of rabbit. Anaerobe,2010,(16):61-65
Middelbos I.S., Vester Boler B.M., Qu A., White B.A., Swanson K.S.. Phylogenetic haracterization of Fecal Microbial Communities of Dogs Fed Diets with or without Supplemental Dietary Fiber Using454Pyrosequencing. Plos One,2010,(5):1-9
Mitsuoka T.. The human gastrointestinal tract. In:Wood BJB, editor. The Lactic Acid Bacteria. Vol.1. The Lactic Acid Bacteria in Health and Disease. London:Elsevier Applied Science,1992:69-114
Miyazawa K., Aso V., Kanaya T., Kido T., Minashima T., Watanabe K., Ohwada V., Kitazawa H., Rose M.T., Tahara K., Yamasaki T., Yamaguchi T.. Apoptotic process of porcine intestinal M cells. Cell Tissue Res,2006,(323):425-432.
Monica K., Oshima S., Anshu P. and Sujata G.. Identification of key proteins of cultured human intestinal cells involved in interaction with enteroaggregative Escherichia coli.2012,DOI:10.1111/j.1574-695X.2012.00998.x
Montagne L., Pluske J.R., Hampson D.J.. A review of interactions between dietary fibre and the intestinal mucosa, and their consequences on digestive health in young non-ruminant animals. Anim. Feed Sci.Technol,2003,(108):95-117
Monteils V., Cauquil L., Combes S., Godon J.-J., Gidenne T.. Potential core species and satellite species in the bacterial community within the rabbit caecum. FEMS Microbiol Ecol,2008,(66):620-629
Moore A.J., Moore P.J.. Female Strategy During Mate Choice:Threshold Assessment. Evolution,1988,(42):387-391
Moore M.N., Livingstone D.R. and Widdows J.. Hydrocarbons in marine molluscs:biological effects and ecological consequences. In Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment (edited by Varanasi V.),1988:291-328.
Moran E.T.. Starch digestion in fowl.Poult.Sri.,1982,(61):1257-1267
Morisse J. P., Boillietot E. and Maurice R.. Alimentation et modifications du milieu intestinal chez le lapin [J]. Recueil Medicine Veterinaire,1985,(161):443-449
Moser I, Schroeder W.&Salnikow J.. Campylobacter jejuni major outer membrane protein and a59-kDa protein are involved in binding to fibronectin and INT407cell membranes. FEMS Microbiol Lett,1997,(157):233-238
Miiller M., Kersten S.. Nutrigenomics:goals and strategies. Nat. Rev. Genet.,2003,(4):315-322
Muyzer G., De Waal E.C., Uitterlinden A.G.. Profiling of complex microbial Populationsby denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for16SrRNA.Appl.Environ.Mierobiol,1993,(59):695-700
Neutra M. R., Mantis N. J., Frey A., Giannasca P. J.. The composition and function of M cell apical membranes:implications for microbial pathogenesis. Semin. Immunol.,1999,(11):171-181
Neutra M.R.. M Cells in antigen sampling in mucosal tissue. Curr. Top. Microbial Immunol.,1999,(236):17-32
Nicodemus N., Garcia J. and De Blas J.C..Effect of inclusion of sunflower hulls in the diet on performance,disaccharidase activity in the small intestine and caecal traits of growing r abbits Animal science,2002,(75):237-243
Padilha M. T. S., Licois D., Gidenne T., Carre B. and Fonty G.. Relationships between microflora and caecal fermentation in rabbits before and after weaning. Reproduction Nutrition Development,1995,(35):375-386
Padilha M.T.S., Licois D., Coudert P.. Frequency of the carriage and enumeration of Escherichia coli in caecal content of15to49day old rabbits. In Proc.:6th World Rabbit Congress,Toulouse, France July09-12,1996,(3):99-102
Pappo J., Owen R.L.. Absence of secretory component expression by epithelial cells overlying rabbit gut-associated lymphoid tissue. Gastroenterology,1988,(95):1173-1177
Parigi-Bini R., Xiccato G. and Cinetto M.. Influenza del contenuto di amido alimentare sulla produttivita,sulla digeribilita e sulla composizione corporea di conigli in accrescimento. Zootecnica e Nutrizione Animale,1990,(16):271-282
Perez J.M., Gidenne T., Bouvarel I., Arveux P., Bourdillon A., Briens C, Le Naour J., Messager B., Mirabito L.. Apports de cellulose dans1'alimentation du lapin en croissance. Ⅱ. Conse quences sur les performances et la mortalite. Ann. Zootech.,1996,(45):299-309
Perez J.M., Gidenne T., Bouvarel I, Arveux P., Bourdillon A., Briens C., Le Naour J., Messager B., Mirabito L.. Replacement of digestible fibre by starch in the diet of the growing rabbit. II. Effects on performances and mortality by polysacdiarrhoea. Ann. Zootech.,2000,(49):369-377
Portsmouth J.I.. The nutrition of the rabbits.In:HaresignW., Swan H.and Lewis D.(eds) Nutriton and the Climatic Environment.Butterworths,London, UK,1977:93-111
Prasadarao N.V., Srivastava P.K., Rudrabhatla R.S., Kim K.S., Huang S.H.&Sukumaran S.K.. Cloning and expression of the Escherichia coli K1outer membrane protein A receptor, a gp96homologue. Infect. Immun.,2003,(71):1680-1688
Pupo G.M., Karaolis D.K.R., Lan R., Reeves P.R.. Evolutionary relationships among pathogenic and nonpathogenic Escherichia coli strains inferred from multilocus enzyme electrophoresis and mdh sequence studies. Infect. Immun,1997,(65):2685-2692
Quevedo F., Cervera C., Blas E., Baselga M. and Pascual J.J.. Long-term effect of selection for litter size and feeding programme on the performance of reproductive rabbit does1. Pregnancy of multiparous does. Animal Science,2006,(82):739-750
Rabbani G.H., Albert M.J., Rahman H., Islam M., Mahalanabis D., Kabir I., Alam K. and Ansaruzzaman M.. Development of an improved animal model of shigellosis in the adult rabbit by colonic infection with Shigella flexneri2a. Infect. Immun,199'5,(63)4350-4357
Rappsilber J., Ryder U., Lamond A.I. and Mann M..Large-Scale Proteomic Analysis of the Human Spliceosome. Genome Res.,2002,(12):1231-1245
Rautenberg K., Cichon C., Heyer G., Demel M., Schmidt M.A.. Immunohistochemical characterization of the follicle-associated epithelium of Peyer's patches:anti-cytokeratin8antibody (clone4.1.18) as a molecular marker for rat M cells. Eur. J. Cell Biol.,1996,(71):363-370
Raynal P., Pollard H.B.. Annexins:the problem of assessing the biological role for a gene family of multifunctional calcium-and phospholipid-binding proteins. Biochim. Biophys. Acta.,1994(1197):63-93
Rechner C., Kuhlewein C., Muller A., Schild H. and Rudel T.. Host glycoprotein Gp96and scavenger receptor SREC interact with PorB of disseminating Neisseria gonorrhoeae in an epithelial invasion pathway. Cell Host Microbe,2007,(2):393-403
Rhee K..-J., Sethupathi P., Driks A., Lanning D.K., Knight K.L.. Role of Commensal Bacteria in Development of Gut-Associated Lymphoid Tissues and Preimmune Antibody Repertoire. J Immunol,2004,(172):1118-1124
Rodriguez-Romero N., Abecia L., Balcells J., Martinez B., Fondevila M.. Comparison of bacterial profile from cecal content and caecotrophes in growing rabbits fed on two levels of indigestible fibre. In Proc.:ⅩⅩⅩⅨ Jornadas de Estudio, ⅩⅢ Jornadas sobre Production Animal, Zaragoza, Espana,12y13de mayo de2009:784-786
Sansonetti P. J., Arondel J., Cantey J. R., Prevost M. C., Huerre M.. Infection of rabbit Peyer's patches by Shigella flexneri:effect of adhesive or invasive bacterial phenotypes on follicle-associated epithelium. Infect. Immun,1996,(64):2752-2764
Sappino A.-P., Schurch W., Gabbiani G.. Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. lab. Invest.,1990,(63):144-161
Savidge T. C., Smith M. W., James P. S., Aldred P.. Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue. Am. J. Pathol.,1991,(139):177-184
Schroder J., Delmann W.E., Winlcler W.,Fandrich F., Schweizer E.,Schroeder P.. Glutamine dipeptide-supplemented parenteral nutrition reverses gut atrophy,disaccharidase enzyme activity,and absorption in rats. JPEN,1995,19(6):502-506.
Schweigert F.J.. Nutritional proteomics:methods and concepts for research in nutritional science. Ann. Nutr. Meta.b,2007,(51):99-107
Sci.USA,1983,(80):1579-1583
Severson K.M., Mallozzi M., Driks A., Knight K.L.. B Cell Development in GALT:Role of Bacterial Superantigen-Like Molecules. The Journal of Immunology,2010,(184):6782-6789
Shepherd M.L., Swecker W.S., Jensen R.V., Ponder M.A.. Characterization of the fecal bacteria communities of forage-fed horses by pyrosequencing of16S rRNA V4gene amplicons. FEMSMicrobiol Lett.,2012,(326):62-68
Sijpesteijn A.K.. On Ruminococcus flavefaciens, a cellulose-decomposing:bacterium from the rumen of sheep and cattle. J. Gen. Microbiol,1951,(5):869-879
Simecka J.W.. Mucosal immunity of the gastrointestinal tract and oral tolerance. Adv. Drug Deliv. Rev,1998,(34):235-259
Singh-Jasuja H.,Toes R.E.,Spee P.,Miinz C, Hilf N., Schoenberger S.P.,Ricciardi-Castagnoli P.,Neefjes J.,Rammensee H.G.,Arnold-Schild D.and Schild H..Crosspresentation of glycoprotein96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis. J. Exp. Med.,1999,(191):1965-1974
Skrivanova V., Copikova J., Sinica A., Marounek M.. Effects of a rabbit diet with sugar-beet pulp on gains, di gestibility of nutrients and quality of rabbit meat. Sci. Agric. Bohemica.,1996,(27):221-227
Soler M. D., Blas E., Cano J. L., Pascual J. J., Cervera C.,Fernandez-Carmona J.. Effect of digestible fiber/starch ratio animal fat level in diets around weaning on mortality rate of rabbits. Proceedings-8th World Rabbit Congress-September7-10,2004-Puebla, Mexico.
Soler M.D., Blas E., Biglia S., Casado C., Moya J. and Cervera C.. Digestibilidad ileal de piensos con distinto contenido en fibra digestible, almidon y grasa animal en gazapos en postdestete. In:Proceedings ⅩⅩⅪ Symposium de Cunicultura, lorca. ASESCU, Canet de Mar, Spain,2006:73-77
Suau A., Bonnet R., Sutren M., Godon J.-J., Gibson G.R., Collins M.D., Dore J.. Direct Analysis of Genes Encoding16S rRNA from Complex Communities Reveals Many Novel Molecular Species within the Human Gut. Appl. Environ. Microbiol.,1999,(65)4799-4807
Tajima K.,AminovR.I., Nagamine T., Matsui H., Nakamura M. and Benno Y. Diet-dependent shifts in the bacterial population of the rumen revealed with real-time PCR. Appl. Environ. Microbiol,2001,(67):2766-2774
Tao Z. Y. and Li F. C. Effects of dietary neutral detergent fibre on productionperformance, nutrient utilization, caecum fermentation and fibrolytic activity in2-to3-month-old New Zealand rabbits. Journal of Animal Physiology and Animal Nutrition,2006,(90):467-473
Tomasek J.J., Gabbiani G., Hinz B., Chaponnier C. and Brown R.A.. Myofi broblasts and mechano-regulation of connective tissue remodelling. Nat. Rev. Mol Cell Biol,2002,(3):349-363
Trowell H.. Ischemic heart disease and dietary fiber. Am. J. Clin. Nutr.,1972,(25):926-932
Turnbaugh P. J., Ley R.E., Mahowald M.A., Magrini V., Mardis E.R., Gordon J.I.. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature,2006,(444):1027-1031
Turnbaugh P.J., Hamady M., Yatsunenko T., Cantarel B.L., Duncan A., Ley R.E., Sogin M.L. Jones W.J., Roe B.A., Affourtit J.P., Egholm M., Henrissat B., Heath A.C., Knight R. and Gordon J.I.. A core gut microbiome in obese and lean twins. Nature,2008,(457):480-484
Tyrer P.C., Ruth Foxwell A., Kyd J.M., Otczyk D.C., Cripps A.W.. Receptor mediated targeting of M-cells. Vaccine,2007,(25):4204-3209
Vanhoutte T., Huys G., De Brandt E., Swings J.. Temporal stability analysis of the microbiota in human feces by denaturing gradient gel electrophoresis using universal and group specific16S rRNA primers. FEMS Microbiol. Ecol.,2004,(48):437-446
Weimer P.J.. Ruminal cellulolytic bacteria:physiology, ecology and beyond. In:USDA-ARS Proceedings of the Dairy Forage Research Center Conference with the Dairy and Forage Industries, Madison, WI.1996:53-60
Wielen P.W.J.J., Keuzenkamp D.A., Lipman L.J.A., Knapen F., Biesterveld S.. Spatial and Temporal Variation of the Intestinal Bacterial Community in Commercially Raised Broiler Chickens During Growth. Microbial Ecology,2002,(44):286-293
Wu S.G., Wang G.T., Angert E.R., Wang W.W., Li W.X., Zou H.. Composition, Diversity, and Origin of the Bacterial Community in Grass Carp Intestine. PLOS one,2012,(7):1-11
Xu K., Geczy C.L.. IFN-gamma and TNF regulat e macrophage expression of the chemotact ic S100prot ein S100A8. J. Immunol.,2000,(164):4916-4923
Xu R., Ho Y.S., Ritchie R.P., Li L.. Human SM22a BAC encompasses regulatory sequences for expression invascular and visceral smooth muscles at fetal and adult stages. Am. J. Heart Circ Physiol.,2003,(284):1398-1407
Yoo B.C., Vlkolinsky R., Engidawork E., Cairns N., Fountoulakis M., Lubec G.. Differential expression of molecular chaperones in brain of patients with Down syndrome. Electrophoresis,2001,(22):1233-1241
Yu B. and Chiou P. W. S.. Effects of crude fibre level in the diet on the intestinal morphology of growing rabbits. Lab. Anim,1996,(30):143-148
Yu B., Tsen H.Y.. Lactobacillus cells in the rabbit digestive tract and factors affecting their distribution. J Appl Bact,1993,(75):269-275
Zhao L., Zhao J., Wang S., Xia Y., Liu J., He J., Wang X.. Evaluation of immunocompatibility of tissue-engineered periosteum. Biomed. Mater.,2011,(6):1-8
Zhao X., J(?)rgensen H., Eggum B.O..The influence of dietary fibre on body composition, visceral organ weight, digestibility and energy balance in rats housed in different thermal environments. Br. J. Nutr.,1995,(73):687-699
Zoetendal E.G.,Akkermans A.D.L., De Vos W.M.. Temperature Gradient Gel Electrophoresis Analysis of16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria. Appl. Environ. Microbiol.,1998,(64):3854-3859