阜康阿魏和豆叶霸王化学成分研究
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摘要
阜康阿魏(Ferula fukanensis K. M. Shen)为药典收载品种，具有杀虫、消积、除痞等作用。文献调研表明其化学成分研究未见报道，为了研究其化学成分，完善和提高该常用中药的质量标准，并为药效药理奠定物质基础，我们为此进行了较系统的化学成分研究。从该植物的低极性部分中分离得到了7种化学成分，通过NMR、MS、IR、UV等光谱分析和理化常数比较，鉴定了7个化合物，其中甾体及其苷类2个，萜类化合物1个，芳香酸酯1个，香豆素类化合物1个，葸醌2个，其中2种化合物为本属中首次发现。通过对其化学成分的系统研究为开发研究新药及提高其质量标准打下了良好的物质基础。
豆叶霸王(Zygophyllum fabag)隶属于蒺藜科(Zygophyllaceae)驼蹄瓣属(Zygophyllum L.)，具有祛热抗炎，降低血糖，抗高血压，止腹泻，抗菌等功效。文献调研表明其化学成分研究未见报道，我们对其进行了较系统的化学成分研究。从该植物中分离鉴定了7种化学成分，它们分别是豆甾-4-烯-3-酮(stigrnast-4-en-3-one)，3-O-[β-D-glucopyranosyl]-quinovic acid，紫云英苷(astragalin)，β-谷甾醇(β-sitoster01)，胡萝卜苷(daucoster01)，正二十八烷醇n-noctacosanol，正三十二烷醇n-dotriacontanol。
此外，本文还综述了阿魏属和驼蹄瓣属植物的化学和药理学研究进展。
Ferula fukanensis, as an important drug collected in Chinese Pharmacopoeia, has been widely used to treat inflammation, dyspepsia and infection in many countries and districts. In order to study the chemical constituents and develop a more efficient quality control project, 7 compounds were isolated from the low polarity part of the 95% EtOH extract of Ferula fukanensis, from them, 7 compounds were structurally identified by means of various modern spectroscopic techniques (NMR, MS, IR.UV and so on ) and on the basis of their physical properties. Among them, two were isolated in the genus Ferula for the first time. The chemical work provided a material base for the quality control and new drug development.
Zygophyllum fabag belongs to the family Zygophyllaceae, the genus Zygophyllum, has been widely used to anti-infammatory, antipyretic, antidiarrhoeal, antihypertensive and lowwing blood glucose. In order to study the chemical constituents and develop a more efficient quality control project, 7 compounds were isolated from the 95% EtOH extract of Zygophyllum fabag. The structures of them were elucidated as follows: stigmast-4-en-3-one, 3-O-[β-D-glucopyranosyl] -quinovic acid, astragalin,β-sitosterol. daucosterol, n-noctacosanol, n-dotriacontanoL.
This thesis also reviewed advances of the chemical and pharmacological studies of the genus Ferula and the genus Zygophyllum.
豆叶霸王(Zygophyllum fabag)隶属于蒺藜科(Zygophyllaceae)驼蹄瓣属(Zygophyllum L.)，具有祛热抗炎，降低血糖，抗高血压，止腹泻，抗菌等功效。文献调研表明其化学成分研究未见报道，我们对其进行了较系统的化学成分研究。从该植物中分离鉴定了7种化学成分，它们分别是豆甾-4-烯-3-酮(stigrnast-4-en-3-one)，3-O-[β-D-glucopyranosyl]-quinovic acid，紫云英苷(astragalin)，β-谷甾醇(β-sitoster01)，胡萝卜苷(daucoster01)，正二十八烷醇n-noctacosanol，正三十二烷醇n-dotriacontanol。
此外，本文还综述了阿魏属和驼蹄瓣属植物的化学和药理学研究进展。
Ferula fukanensis, as an important drug collected in Chinese Pharmacopoeia, has been widely used to treat inflammation, dyspepsia and infection in many countries and districts. In order to study the chemical constituents and develop a more efficient quality control project, 7 compounds were isolated from the low polarity part of the 95% EtOH extract of Ferula fukanensis, from them, 7 compounds were structurally identified by means of various modern spectroscopic techniques (NMR, MS, IR.UV and so on ) and on the basis of their physical properties. Among them, two were isolated in the genus Ferula for the first time. The chemical work provided a material base for the quality control and new drug development.
Zygophyllum fabag belongs to the family Zygophyllaceae, the genus Zygophyllum, has been widely used to anti-infammatory, antipyretic, antidiarrhoeal, antihypertensive and lowwing blood glucose. In order to study the chemical constituents and develop a more efficient quality control project, 7 compounds were isolated from the 95% EtOH extract of Zygophyllum fabag. The structures of them were elucidated as follows: stigmast-4-en-3-one, 3-O-[β-D-glucopyranosyl] -quinovic acid, astragalin,β-sitosterol. daucosterol, n-noctacosanol, n-dotriacontanoL.
This thesis also reviewed advances of the chemical and pharmacological studies of the genus Ferula and the genus Zygophyllum.
引文
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[2] Saidkhodzhaev AV. Sesquiterpene derivative of Ferula L. Khim Prir Soedin, 1979, (4): 437
[3] Sagirtdinova GV, Saidkhodzhaev AV, Malikov VM. Structure and stereochemistry of the coumarins of Ferula lehmannii. Khim Prir Soedin, 1983, (8): 709
[4] Veselovskaya NV, Sklyarl YE, Fesenko DA, et al. Fekrol-a terpenoid coumarin from Ferula krylovii. Khim Prir Soedin, 1979, (6): 851
[5] Veselovskaya NV. Khim Prir Soedin, 1981, (4): 798
[6] Kuliev ZA, Khasanev TK, Malikov VM. Coumarins ofFerula conocaula. Khim Prir Soedin, 1982, (1): 120
[7] Kuliev ZA, Khasanev TK, Malikov VM. Structure and configuration of cauferinin. Khim Prir Soedin, 1979, (2): 151
[8] 顾新宇，张涵庆，薛怡琛，等．大果阿魏酮化学结构的研究．植物资源与环境，1995，(2)：13～16
[9] Saidkhodzhaev AV, Mamatkhanov AU. Terpenonids of plant of the Ferula Genus I: Natural carotane derivatives. Khim Prir Soedin, 1995, (6): 767
[10] 刘启新，惠红．阿魏属挥发油成分及分类学意义．植物资源与环境，1997，6(2)：26～31
[11] 倪慧，姜传义，刘淑兰，等．阿魏属中挥发油成分的比较研究．中草药，1997，28(6)：331
[12] 倪慧，姜传义，刘淑兰，等．新疆多伞阿魏中挥发油成分报道．中药材，1997，20(1)：34
[13] 朱耕新，张涵庆．铜山阿魏根化学成分的研究．中国药科大学学报，1996，27(10)：585
[14] 戴斌，丘翠嫦．中国传统药物阿魏挥发油成分的气相色谱～质谱分析比较．药 物分析杂志，12(5)：285
[15] NazhimitdinovNN. Khim Prir Soedin, 1994, (4): 504
[16] GargSN, AgarwalSK. Phytochenisty, 1988, 27(3): 936～937
[17] Garg SN, Misra LN, Agarwal SK. Phytochenisty, 1989, 28(2): 634～636
[18] Golovina LA, Saidkhodzhaev AV. Khim Prir Soedin, 1987, (5): 763
[19] Gonzalev AG, Diaz JG. Phytochemisty, 1993, 33: 863-866
[20] Min Zhida, Mai Qifi, Mizuno M, et al. Polysulfanes in the volatile oils of Ferula species. Plant Medica, 1987, 53(3): 300～302.
[21]．陈晓亚，刘启新．中国阿魏属的黄酮体成分及其分类学意义．植物分类学报，1989，27(3)：184～189
[22] CA114: 18203
[23] 王年鹤，袁昌齐，马场江，等．铜山阿魏和草甸阿魏根的化学成分及其系统分类学意义．植物资源与环境，1997，6(4)：15～18
[24] 朱耕新，张涵庆．铜山阿魏根中的一个新化合物．中国药科大学学报，1998，29(1)：19～20
[25] CA108: 128486d
[26] CA110:. 72512f
[27] 杨宗孟，等．中药阿魏抗生育的动物实验观察小结．吉林中医药，1982，(4)：42
[28] CA 103: 135341c: CA108: 101333q
[29] Singh M M, Agnihotri A, Gupla D N, Planta medica 1988, 54(6): 492～494
[30] 王大铭，等．阿魏对小鼠、家兔离体子宫的作用极其与体内雌激素和孕酮水平的关系．中草药，1986，17(4)：28
[31] SinghMM, GuplaDN, WadhwaV. PlantaMediea, 1995, (3): 412
[32] 张洪泉，等．新疆阿魏抗过敏的药理作用．中药通报，1986，11(8)：49
[33] 张洪泉，等．中药通报，1986，13(5)：45
[34] 胡慧娟，杭秉茜，王朋书，等．阿魏酸的抗炎作用．中国药科大学学报，1990，21(5)：279～282
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