补充复合中药对运动大鼠心肌损伤标志物及CGRP含量的影响
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摘要
目的：CGRP在心肌细胞保护方面具有重要的作用。中药是中国的国粹,在体育界一直被作为重要的抗疲劳药物。本研究试图通过建立大强度训练训练模型,观察6周的递增负荷跑台训练和复方中药对大鼠心肌损伤标志物、CGRP及CGRP mRNA含量的影响,探求该中药复合物保护心肌的机制,以期为复合中药作为一种保护心肌、抗运动性疲劳的药物提供实验依据。
方法：50只八周龄雄性SD大鼠,分为5组,每组10只；安静组(A组)、安静给药组(B组)、运动组(D组)、运动中剂量组(E组)、运动大剂量组(F组)。大鼠正常饲料喂养,B组和E组大鼠以中药浓度为0.1g/kg进行灌胃,F组大鼠以中药浓度为0.2g/kg进行灌胃,其它组大鼠灌胃等量的饮用水。各运动组进行6周的递增负荷训练。6周训练后即刻,大鼠腹腔麻醉,取血和心脏待测。比色法测量血清中心肌酶损伤标志酶的含量,比色法测定血清中抗氧化酶SOD、GSH-Px的含量,放射免疫分析法测定血清和心肌组织中CGRP的含量,采用RT-PCR检测心肌组织中CGRP mRNA的含量。
结果：1.与A组相比,D组大鼠血清中ALT、LDH、a-HBDH非常显著性增高,CK显著性增高。与D组相比,E组大鼠血清中ALT、LDH非常显著降低,CK、a-HBDH显著降低,F组大鼠ALT、CK显著降低。与E组相比,F组大鼠血清中LDH显著增高,其它指标没有差异。2.各组大鼠之间血清SOD含量和GSH-Px含量均无显著性差异。3. CGRP含量变化：与A组相比D组大鼠血清中有升高的趋势,但无差异,心肌组织非常显著性降低。与D组相比E组大鼠血清中显著升高,心肌中无显著差异,F组血清中非常显著升高,心肌中显著降低。E、F组之间没有差异。4.心肌中α-CGRP mRNA表达量：与A组相比B组没有显著性变化,D组大鼠显著升高；与D组相比E组非常显著性降低,F组大鼠显著降低。
结论：1.6周的递增负荷训练使大鼠血清心肌标志酶活性增加,心肌出现损伤。同时使心肌组织中CGRP含量降低,CGRP mRNA表达量显著升高。2.复合中药能够显著降低大强度训练引起的血清心肌标志酶活性,减轻大强度心率引起的心肌损伤程度；中药是通过增加血清中CGRP的含量来实现缓解大强度训练对心肌的损伤；但两种剂量之间的效果没有明显的差异。
Object:CGRP is very important in protecting the cardiac muscle. Chinese medicine is our Chinese quintessence, which has been regard as a medicine to resist fatigue. This research intends to make the model of hard training rats, and observing changes of indexes, CGRP and CGRP mRNA, after6weeks training and intake Chinese medicine. Through this experiment, we want to find out the mechanics behind the Chinese medicine which could protect cardiac muscles.
Method:50eight-week-old male SD rats. Rates are separated into5groups, with10for each group (N=10). There are quiet group with no medicine (A), the quiet and fed medicine group (B), exercise group (D), exercise with medicine group (E), exercise and the high-dose group (F group). Rates were fed normally, group B and group E rats were digested by0.1g/kg traditional Chinese medicine, group F with0.2g/kg traditional Chinese medicine concentration, other group fed the same amount saline. All groups had been trained for6weeks. After that, rates were killed immediately with peritoneal anesthesia. Experiment took blood and heart to be samples. Experiment used colorimetric determination of serum antioxidant enzymes SOD, GSH-Px content radioimmunoassay Determination of serum and myocardial tissue calcitonin gene-related peptide (CGRP) content, using RT-PCR detection of myocardial tissue content of CGRP mRNA.
Result:1. Comparing to group A, Group D has significant increase of serum ALT, LDH, and a-HBDH. Comparing to Group D, Group E has significant decrease of serum ALT, LDH, CK, and a-HBDH. Comparing to group E, group F has significant increase of serum LDH, with no significant changes among other indexes.2. There are no significant changes in serum SOD, and GSH-Px in each group.3. Changes of CGRP:Comparing to Group A, Group D has increasing tide, without any significant reluctance. But the myocardial tissue has decreased significantly. Comparing to GroupD, Group E has significant increasing of serum CGRP, without obvious changes in myocardial tissue. But Group F has significant increasing of serum CGRP, with significant decreasing in myocardial tissue. There are no significant changes between group E and F.4. Expression of α-CGRP mRNA: Comparing to Group A, group B has no significant changes, but group D has significant increasing. Comparing group D, group E has significant decreasing, and group F also has significant decreasing.
Conclusion:1. After6weeks incremental load training, there more injuries happened among cardiac muscle. Simultaneously, CGRP's contents has been decreased with much expression of CGRP mRNA.2. Chinese medicine can effective inhibit ascending of serum cardiac marker enzyme activity and alleviate cardiac injured caused by high seep of hear rat. Through enhancing CGRP's content in serum, cardiac injury will be mitigated. However there is no distinguishing difference between two dosages.
方法：50只八周龄雄性SD大鼠,分为5组,每组10只；安静组(A组)、安静给药组(B组)、运动组(D组)、运动中剂量组(E组)、运动大剂量组(F组)。大鼠正常饲料喂养,B组和E组大鼠以中药浓度为0.1g/kg进行灌胃,F组大鼠以中药浓度为0.2g/kg进行灌胃,其它组大鼠灌胃等量的饮用水。各运动组进行6周的递增负荷训练。6周训练后即刻,大鼠腹腔麻醉,取血和心脏待测。比色法测量血清中心肌酶损伤标志酶的含量,比色法测定血清中抗氧化酶SOD、GSH-Px的含量,放射免疫分析法测定血清和心肌组织中CGRP的含量,采用RT-PCR检测心肌组织中CGRP mRNA的含量。
结果：1.与A组相比,D组大鼠血清中ALT、LDH、a-HBDH非常显著性增高,CK显著性增高。与D组相比,E组大鼠血清中ALT、LDH非常显著降低,CK、a-HBDH显著降低,F组大鼠ALT、CK显著降低。与E组相比,F组大鼠血清中LDH显著增高,其它指标没有差异。2.各组大鼠之间血清SOD含量和GSH-Px含量均无显著性差异。3. CGRP含量变化：与A组相比D组大鼠血清中有升高的趋势,但无差异,心肌组织非常显著性降低。与D组相比E组大鼠血清中显著升高,心肌中无显著差异,F组血清中非常显著升高,心肌中显著降低。E、F组之间没有差异。4.心肌中α-CGRP mRNA表达量：与A组相比B组没有显著性变化,D组大鼠显著升高；与D组相比E组非常显著性降低,F组大鼠显著降低。
结论：1.6周的递增负荷训练使大鼠血清心肌标志酶活性增加,心肌出现损伤。同时使心肌组织中CGRP含量降低,CGRP mRNA表达量显著升高。2.复合中药能够显著降低大强度训练引起的血清心肌标志酶活性,减轻大强度心率引起的心肌损伤程度；中药是通过增加血清中CGRP的含量来实现缓解大强度训练对心肌的损伤；但两种剂量之间的效果没有明显的差异。
Object:CGRP is very important in protecting the cardiac muscle. Chinese medicine is our Chinese quintessence, which has been regard as a medicine to resist fatigue. This research intends to make the model of hard training rats, and observing changes of indexes, CGRP and CGRP mRNA, after6weeks training and intake Chinese medicine. Through this experiment, we want to find out the mechanics behind the Chinese medicine which could protect cardiac muscles.
Method:50eight-week-old male SD rats. Rates are separated into5groups, with10for each group (N=10). There are quiet group with no medicine (A), the quiet and fed medicine group (B), exercise group (D), exercise with medicine group (E), exercise and the high-dose group (F group). Rates were fed normally, group B and group E rats were digested by0.1g/kg traditional Chinese medicine, group F with0.2g/kg traditional Chinese medicine concentration, other group fed the same amount saline. All groups had been trained for6weeks. After that, rates were killed immediately with peritoneal anesthesia. Experiment took blood and heart to be samples. Experiment used colorimetric determination of serum antioxidant enzymes SOD, GSH-Px content radioimmunoassay Determination of serum and myocardial tissue calcitonin gene-related peptide (CGRP) content, using RT-PCR detection of myocardial tissue content of CGRP mRNA.
Result:1. Comparing to group A, Group D has significant increase of serum ALT, LDH, and a-HBDH. Comparing to Group D, Group E has significant decrease of serum ALT, LDH, CK, and a-HBDH. Comparing to group E, group F has significant increase of serum LDH, with no significant changes among other indexes.2. There are no significant changes in serum SOD, and GSH-Px in each group.3. Changes of CGRP:Comparing to Group A, Group D has increasing tide, without any significant reluctance. But the myocardial tissue has decreased significantly. Comparing to GroupD, Group E has significant increasing of serum CGRP, without obvious changes in myocardial tissue. But Group F has significant increasing of serum CGRP, with significant decreasing in myocardial tissue. There are no significant changes between group E and F.4. Expression of α-CGRP mRNA: Comparing to Group A, group B has no significant changes, but group D has significant increasing. Comparing group D, group E has significant decreasing, and group F also has significant decreasing.
Conclusion:1. After6weeks incremental load training, there more injuries happened among cardiac muscle. Simultaneously, CGRP's contents has been decreased with much expression of CGRP mRNA.2. Chinese medicine can effective inhibit ascending of serum cardiac marker enzyme activity and alleviate cardiac injured caused by high seep of hear rat. Through enhancing CGRP's content in serum, cardiac injury will be mitigated. However there is no distinguishing difference between two dosages.
引文
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