凋亡抑制基因SURVIVIN在喉癌中的表达及与caspase-3，p53，cyclin E及ki-67之间的关系
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摘要
目的：喉癌是耳鼻咽喉科最常见的恶性肿瘤之一，它的形成是多种体内外因素共同作用的结果。细胞凋亡功能的异常将导致肿瘤的形成。Survivin是新近发现的一种凋亡抑制蛋白基因。本文研究了凋亡抑制蛋白Survivin与喉癌的发生发展关系，应用半定量RT-PCR方法和免疫组化方法对喉癌组织、癌旁组织及正常的喉粘膜组织中的Survivin的表达进行了分析，以了解Survivin在喉癌中的表达情况，同时探讨Survivin的表达与喉癌的发生有无联系。还应用免疫组化的方法对喉癌组织、喉粘膜白斑组织及成人喉乳头状瘤组织中Survivin蛋白的表达进行了探讨，为临床早期诊断喉癌，判断喉癌的预后寻找标记物。并对喉癌组织中Survivin蛋白与caspase-3、p53、cyclin E及ki-67之间的相互关系进行了研究，以了解它们在喉癌中的共同作用。
方法：将经病理确诊的新鲜的喉癌组织20例、癌旁组织18例及正常的喉粘膜组织10例用半定量RT-PCR方法检测Survivin mRNA的表达情况，同时测序证实所表达产物确为Survivin；取经病理确诊的喉癌组织46例、喉粘膜白斑组织28例和喉乳头状瘤组织20例，用免疫组化的方法检测Survivin蛋白的表达，并对喉癌组织中Survivin蛋白的表达情况与临床病理方面的指标的相关性进行了分析；同时用免疫组化的方法对46例喉癌组织、18例癌旁组织和10例正常的喉粘膜组织中caspase-3、p53、cyclin E及ki-67蛋白的表达分别进行了研究，分别探讨了Survivin与caspase-3、p53、cyclin E及ki-67之间的相关性。
结果：在所有的喉癌组织和癌旁组织中均有Survivin基因的表达，但两者的表达量有着显著性差异(p＜0.001)，癌组织中的表达高于癌旁组织中的表达，在正常的喉粘膜中没有Survivin基因的表达；在71.7％的喉癌组织，38.9％的癌旁组织中有Survivin蛋白的表达，两者之间存在显著性差异(p＜0.001)，但在喉癌组织中Survivin蛋白的表达与年龄、性别、肿瘤的位置、临床分期、病理分级和淋
Objective: Laryngeai carcinoma is one of the most common malignant neoplasms in the otorhinolarynogology. Carcinogenesis is a multistage process involving the activation of oncogenes , the inactivation of tumor suppressor genes and the carcinogenic circumstance. Abnormalities in the control of apoptosis play an important role in tumorigensis. Survivin is a novel inhibitors of apoptosis proteins gene. To investigate the relationship between Survivin and the development of laryngeai carcinoma, we studied the expression of survivin in laryngeai carcinoma, adjacent nontumorous laryngeai epithelium and normal laryngeai epithelium by semi-quantitative RT-PCR and immunohistochemistry. To determine the potential involvement of survivin in laryngeai carcinogenesis and to search a marker for early diagnosis and prognostic value of laryngeai carcinoma, we investigated the distribution of survivin protein expression in laryngeai carcinoma, laryngeai leukoplakias and laryngeai papillomas in adults. We also analyzed the relationship between the expression of survivin protein and the expression of caspase-3, p53, cyclin-E, ki-67 proteins in laryngeai carcinoma by immunohistochemistry in order to study their combined effect in laryngeai carcinoma.
Methods: Fresh tissues of 20 cases laryngeai carcinoma, 18 cases adjacent nontumorous laryngeai epithelium and 10 normal laryngeai epithelium were examined the survivin expression by semi-quantitative RT-PCR which were proved by sequencer analysis. The expression of survivin protein was detected by
方法：将经病理确诊的新鲜的喉癌组织20例、癌旁组织18例及正常的喉粘膜组织10例用半定量RT-PCR方法检测Survivin mRNA的表达情况，同时测序证实所表达产物确为Survivin；取经病理确诊的喉癌组织46例、喉粘膜白斑组织28例和喉乳头状瘤组织20例，用免疫组化的方法检测Survivin蛋白的表达，并对喉癌组织中Survivin蛋白的表达情况与临床病理方面的指标的相关性进行了分析；同时用免疫组化的方法对46例喉癌组织、18例癌旁组织和10例正常的喉粘膜组织中caspase-3、p53、cyclin E及ki-67蛋白的表达分别进行了研究，分别探讨了Survivin与caspase-3、p53、cyclin E及ki-67之间的相关性。
结果：在所有的喉癌组织和癌旁组织中均有Survivin基因的表达，但两者的表达量有着显著性差异(p＜0.001)，癌组织中的表达高于癌旁组织中的表达，在正常的喉粘膜中没有Survivin基因的表达；在71.7％的喉癌组织，38.9％的癌旁组织中有Survivin蛋白的表达，两者之间存在显著性差异(p＜0.001)，但在喉癌组织中Survivin蛋白的表达与年龄、性别、肿瘤的位置、临床分期、病理分级和淋
Objective: Laryngeai carcinoma is one of the most common malignant neoplasms in the otorhinolarynogology. Carcinogenesis is a multistage process involving the activation of oncogenes , the inactivation of tumor suppressor genes and the carcinogenic circumstance. Abnormalities in the control of apoptosis play an important role in tumorigensis. Survivin is a novel inhibitors of apoptosis proteins gene. To investigate the relationship between Survivin and the development of laryngeai carcinoma, we studied the expression of survivin in laryngeai carcinoma, adjacent nontumorous laryngeai epithelium and normal laryngeai epithelium by semi-quantitative RT-PCR and immunohistochemistry. To determine the potential involvement of survivin in laryngeai carcinogenesis and to search a marker for early diagnosis and prognostic value of laryngeai carcinoma, we investigated the distribution of survivin protein expression in laryngeai carcinoma, laryngeai leukoplakias and laryngeai papillomas in adults. We also analyzed the relationship between the expression of survivin protein and the expression of caspase-3, p53, cyclin-E, ki-67 proteins in laryngeai carcinoma by immunohistochemistry in order to study their combined effect in laryngeai carcinoma.
Methods: Fresh tissues of 20 cases laryngeai carcinoma, 18 cases adjacent nontumorous laryngeai epithelium and 10 normal laryngeai epithelium were examined the survivin expression by semi-quantitative RT-PCR which were proved by sequencer analysis. The expression of survivin protein was detected by
引文
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傅松滨主编 医学生物学 第6版 人民卫生出版社出版 2004年
同济医科大学生化教研室 同济医科大学研究生讲义——高级生化讲座(基因、蛋白质和细胞信息传递)，1998年
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杨抚华，胡以平主编 医学细胞生物学 科学出版社出版，2002年300-3061
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吕正华 栾信庸 喉癌临床治疗的辩证思维——浅谈当前临床医学为什么需要哲学．医学与哲学2005年1月第26卷第1期 34-35。
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傅松滨主编 医学生物学 第6版 人民卫生出版社出版 2004年
同济医科大学生化教研室 同济医科大学研究生讲义——高级生化讲座(基因、蛋白质和细胞信息传递)，1998年
王梅，王冰，王小丽等。Survivin在宫颈上皮内瘤样变及宫颈癌中的表达的初步研究。肿瘤研究及临床，2001，13(4)：229-231。
杨抚华，胡以平主编 医学细胞生物学 科学出版社出版，2002年300-3061
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