用户名: 密码: 验证码:
电子垃圾中多氯联苯的环境转移和潜在的健康风险
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
当前,电子垃圾已成为世界上增长速度最快的固体废弃物。在我国,进口的和国内淘汰的电子垃圾数量都十分巨大。随着近年来经济的飞速发展,我国对各种原材料的需求急剧增加,回收废弃物资,利用再生资源是解决目前我国资源困境的一种有效途径。由于电子垃圾中80%~90%的物质是有价值可利用的,在原材料需求和经济效益的驱动下电子垃圾拆解业在我国沿海地区迅速发展,特别是广东贵屿和浙江台州已发展成国内两个最大的电子垃圾拆解基地。本文以浙江台州的典型电子垃圾拆解区LQ为试验点,以废旧变压器和电力电容器的绝缘油中所含的PCBs为模型化合物来研究了电子垃圾中PCBs的环境转移、污染特征及其潜在的健康风险。
     从选择的三个试验点(LQ,PQ和LA)采集了大量的环境和人体组织样品。采用GC/ECD技术对样品中的PCBs进行分析;采用Micro-EROD生物测试法检测人体组织样品提取液的二噁英类毒性;利用拆解现场获得的变压器油进行活体暴露试验,研究了变压器油对斑马鱼的毒性影响。在此基础上,还对当地居民潜在的健康风险作出了初步评价。获得的主要研究结果如下:
     1.试验点LQ的所有环境和人体组织样品中均能检出PCBs,而且稻谷、鱼和鸡蛋、脐血、胎便和乳汁样品中PCBs的含量明显高于试验点PQ和LA采集的同类样品中PCBs的含量。对现场采集的变压器油的分析结果表明,其PCBs的浓度指纹与商业混合物Aroclor1242和1260的浓度指纹相吻合,表明该地区的PCBs污染主要源于电子垃圾的拆解。
     2.乳汁与脐血中PCBs的浓度之间有显著的相关性(R2 > 0.39; P < 0.05),说明PCBs在母婴之间发生了传递,胎儿在母体内受到了PCBs的暴露。胎便与脐血中PCBs的浓度之间也呈显著相关(R2 > 0.2491; P < 0.001),表明胎便是胎儿出生前PCBs暴露的一种有效生物指示物。
     3. Micro-EROD生物测试结果显示,乳汁、脐血和胎便样品的提取液对EROD的活性有明显诱导。但发现生物测试的结果高于化学分析的结果,而且生物测试的TEQs在这三类样品之间没有显著的相关性,表明样品中存在一些化学分析尚未检测、但又能诱导EROD活性的其他二噁英类化合物。
     4.斑马鱼暴露试验发现环境水平的变压器油暴露能够明显诱导鱼肝细胞中
Electrical and electronic waste (e-waste) has become the fastest growing stream among all the solid waste around the world. In China, the amounts of e-waste increases rapidly in recent years; these e-wastes can be sourced both domestically discarded products and imported waste. The demand for materials is on the increase with expanding economy. Recycling materials from e-waste is an effective way to obtain scarce industry raw materials. There are about 80 to 90 percent of substances in e-waste are valuable and reusable. The demand for recycled materials and the potential economy benefit are promoting the development of disassembly industry of e-waste in littoral. Guiyu, Guangdong and Taizhou, Zhejiang are the two largest e-waste disassembling areas in China.
     Because of their excellent stability and electrical insulation, PCBs were once widely used in transformers and capacitors. In this study PCBs were determined as target compounds; LQ (the disassembly site, located in Taizhou), LA and PQ (the non-disassembly sites) in Zhejiang were selected as the sampling sites. The collected environment and human samples included: transformer oil, river water, river sediment, paddy soil, rice, eggs, fish, cord blood, milk and newborn meconium samples. Chemical analysis was performed using a HP6890 GC/ECD. Micro-EROD bioassay was used to screen for the presence of dioxin-like pollutants in extracts of cord blood, milk and meconium samples. Zebrafish exposed by transformer oil was used to assess the toxicological effects on fish. In addition, the potential health risk was estimated
引文
1.Afghan BK, Chau ASY. 1989 Analysis of trace organics in the aquatic environment. Boca Raton, FL: CRC Press, Inc., 33-68.
    2.Ahlborg UG. 1994 Toxic equivalency factors for dioxin-like PCBs. Report on a WHO-ECEH and IPCS consultation, December 1993. Chemosphere 28:1049-1967.
    3.Albro PW, Corbett JT, Schroeder JL. 1981 Quantitative characterization of polychlorinated biphenyl mixtures (Aroclors 1248, 1254 and 1260) by gas chromatography using capillary columns. J Chromatogr 205:103.
    4.Albro PW, Fishbein L. 1972 Intestinal absorption of polychlorinated biphenyls in rats. Bull Environ Contam Toxicol 8:26-31.
    5.Andric NL, Andric SA, Zoric SN, Kostic TS, Stojilkovic SS, Kovacevic RZ. 2003 Parallelism and dissociation in the action of an Aroclor 1260-based transformer fluid on testicular steroidogenesis and antioxidant enzymes. Toxicology194:65-75.
    6.Andric NL, Kostic TS, Zoric SN, Stanic BD, Andric SA, Kovacevic RZ. 2006 Effect of a PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes. Reprod Toxicol (in press)
    7.Andric SA, Kostic TS, Dragisic SM, Andric NL, Stojilkovic SS, Kovacevic RZ. 2000 Acute effects of polychlorinated biphenyl-containing and -free transformer fluids on rat testicular steroidogenesis. Environ Health Perspect 108:955-959.
    8.Ayotte P, Dewailly E, Ryanc JJ, Bruneau S, Lebel G. 1997 PCBs and dioxin-like compounds in plasma of adult Inuit living Nunavik. Chemosphere 34(5-1):1459-1468.
    9.Ayotte P, Muckle G, Jacobson, JL, Jacobson SW and Dewailly éric. 2003 Assessment of Pre- and Postnatal Exposure to Polychlorinated Biphenyls: Lessons from the Inuit Cohort Study. Environ Health Perspect 111:1253-1258.
    10.Ballschmiter K, Zell M. 1980 Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography. Composition of technical Aroclor- and Clophen-PCB mixtures. Fresenius Z Anal Chem 302:20.
    11.BAN (The Basel Action Network) & Silicon Valley Toxicity (SVTC). 2002 Exporting harm: the high-tech trashing of Asia. Seattle,WA, and San Jose, CA. http://www.svtc.org/cleancc/pubs/technotrash.
    12.Bannister R, Safe S. 1987 Synergistic interaction of 2,3,7,8-TCDD and 2,2’,4,4’,5,5’ -hexachlorobiphenyl in C57BL/6J and FBA/2J mice: role of the Ah receptor. Toxicology 44:159.
    13.Becher G. 1995 PCDDs, PCDFs and PCBs in human milk from different parts of Norway and Lithuania. Journal of toxicology and environmental health 46:133-148.
    14.Beck H. 1994 Occurrence in food human tissues and human milk. Proceedings from the Toxicology Forum on Chlorinated organic chemicals. Their effect on human health and the environment, Berlin, Germany.
    15.Bencko V, ?erná M, Jech L, ?míd J. 2004 Exposure of breast-fed children in the Czech Republic to PCDDs, PCDFs, and dioxin-like PCBs. Environmental Toxicology and Pharmacology 18:83-90.
    16.Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A. 1998 Low inducibility of CYP1A activity by polychlorinated biphenylas (PCBs) in flounder (Platichthys flesus): Characterization of the Ah receptor and the role of CYP1A inhibition. Toxicol Sci 43:161-171.
    17.Bi X, Chu S, Meng Q, Xu X. 2002 Movement and retention of polychlorinated biphenyls in a paddy field of WenTai area in China. Agriculture Ecosystems and Environment 89:241-252.
    18.Biegel L, Harris M, Davis D, Rosengren R, Safe S, Safe S. 1989 2,2’,4,4’,5,5’-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice. Toxico Appl Pharmacol 97:561.
    19.Billsson K, Westerlund L, Tysklind M, O1ssona P. 1998 Developmental disturbances caused by Polychlorinated Biphenyls in Zebrafish (Brachydanio rerio). Mar Environ Res 46:461-464.
    20.Birnbaum LS, Weber H, Harris MW, Lamb JC, Mckinney JD. 1985 Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin: increase incidence of cledt palate in mice. Toxico Appl Pharmacol 77:292.
    21.Bjerregaard P, Hansen JC. 2000 Organochlorines and heavy metals in pregnant women from the Disko Bay area in Greenland. Sci Total Environ 245:195-202.
    22.Blais JM. 2005 Biogeochemistry of persistent bioaccumulative toxicants: processes affecting the transport of contaminants to remote areas. Can J Fish Aquat Sci 62: 236-243.
    23.Bocquené G, Roig A, Fournier D. 1997 Cholinesterases from the common oyster (Crassostrea gigas). Evidence for the presence of a soluble acetylcholinesterase insensitive to organophosphate and carbamate inhibitors. FEBS Letters:1-6.
    24.Boersma ER. 1994 Cord blood levels of potentially neurotoxic pollutants (polychlorinated biphenyls, lead and cadmium) in the areas of Prague (Czech Republic) and Katowice (Poland). Comparison with reference values in the Netherlands. Central European Journal of Public Health 2:73-76.
    25.Bordet F, Mallet J, et al. 1993 Organochlorine pesticide and PCB congener content of French human milk. Bull Environ Contam Toxicol 50:425-432.
    26.Bosveld ATC, Kennedy SW, Seinen W, Van den Berg M. 1997 Ethoxyrufin- O-deethylase (EROD) inducing potencies of planar chlorinated aromatic hydrocarbons in primary cultures of hepatocytes from different developmental stages of the chicken. Arch Toxicol 71:746.
    27.Bradford MM. 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1-2):248-254.
    28.Brown AP, Ganey PE. 1995 Neutrophil degranulation and superoxide production induced by polychlorinated biphenyls are calcium dependent. Toxicol Appl Pharmacol 131:198-205.
    29.Brown DP, Jones M. 1981 Mortality and industrial hygiene study of workers exposed to polychlorinated biphenyls. Arch Environ Health 36:120-129.
    30.Brown DP. 1987 Mortality of workers exposed to polychlorinated biphenyls -An update. Arch Environ Health 42(6):333-339.
    31.Brown JF. 1994 Determination of PCB metabolic, excretion, and accumulation rates for use as indicators of biological response and relative risk. Environ Sci Technol 28:2295-2305.
    32.Brown JJF, Lawton RW, Morgan CB. 1994a PCB metabolism, persistence, and health effects after occupational exposure: Implications for risk assessment. Chemosphere 29:2287-2294.
    33.Brown JJF. 1994b Metabolic alterations of PCB residues in aquatic fauna: distributions of cytochrome P450lA- and P4502B-like activities. Mar Environ Res 34:261-266.
    34.Bruckner JV, Jiang WD, Brown JM, et al. 1977 The influence of ingestion of environmentally encountered levels of a commercial polychlorinated biphenyl mixture (Aroclor 1254) on drug metabolism in the rat. J Pharmacol Exp Ther 202:22-31.
    35.Bruckner JV, Khanna KL, Cornish HH. 1973 Biological responses of the rat to polychlorinated biphenyls. Toxicol Appl Pharmacol 24:434-448.
    36.Brumley CM, Haritos VS, Ahokas JT, Holdway DA. 1995 Validation of biomarkers of marine pollution exposure in sand flathead using Aroclor 1254. Aquat Toxicol 31:249-262.
    37.Burgin DE, Diliberto JJ, Derr-Yellin EC, Kannan N, Kodavanti PRS, Birnbaum LS. 2001 Differential effects of two lots of Aroclor 1254 on enzyme induction, thyroid hormones, and oxidative Stress. Environ Health Perspect 109:1163-1168.
    38.Byrne JJ, Carbone JP, Pepe MG. 1988 Suppression of serum adrenal cortex hormones by chronic low-dose polychlorobiphenyl or polybromobiphenyl treatments. Arch Environ Contam Toxicol 17:47-53.
    39.California Regional Water Quality Control Board San Fransico Bay Region. 2001 Polychlorinated biphenyls in San Fransico Bay: sources and loadings report.
    40.Capel PD, Rapaport RA, Eisenreich SJ, Looney BB. 1985 PCBQ: Computerized quantification of total PCB and congeners in environmental samples. Chemosphere 14:439-450.
    41.Carney SA, Peterson RE, Heideman W. 2004 2,3,7,8-Tetrachloro dibenzo-p-dioxinactivation of the arylhydrocarbon receptor/ arylhydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYP1A-independent mechanism in Zebrafish. Mol Pharmacol 66:512-521.
    42.Carr RL, Richardson JR, Guarisco JA, Kachroo A, Chambers JE, Couch TA, Durunna GC, Meek EC. 2002 Effects of PCB exposure on the toxic impact of organophosphorus insecticides. Toxicol sci 67:311-321
    43.CCME (Canadian Council of Ministers of the Environment): 2002, Summary of Existing Canadian Environmental Quality Guidelines. (http://www.ccme.ca/assets/ pdf/e1_06.pdf)
    44.Chao HR, Wang SL, Lin TC, Chung XH. 2006 Levels of organo- chlorine pesticides in human milk from central Taiwan. Chemosphere 62(11):1774-1785.
    45.Chase KH, Wong O, Thomas D, et al. 1982 Clinical and metabolic abnormalities associated with occupational exposure to polychlorinated biphenyls (PCBs). J Occup Med 24:109-114.
    46.Chen G, White PA. 2004 The mutagenic hazards of aquatic sediments: a review. Mutation Research 567:151-225.
    47.Code of Federal Regulations (CFR) 40 Part 136-- Definition and Procedure for the Determination of the Method Detection Limit -- Revision 1.11, Appendix B, U.S. Government, Washington D.C. 20402-9328, 554-555 (1993).
    48.Colombi A, Maroni M, Ferioli A, et al. 1982 Increase in urinary porphyrin excretion in workers exposed to polychlorinated biphenyls. J Appl Toxicol 2:117-121.
    49.Colombo A, Orsi F, Bonfanti P. 2005 Exposure to the organophosphorus pesticide chlorpyrifos inhibits acetylcholinesterase activity and affects muscular integrity in Xenopus laevis larvae. Chemosphere 61:1665-1671.
    50.Courtney Douglas Sandau BS. 2000 Analytical Chemistry of hydroxylated metabolites of PCBs and other halogenated phenolic compounds in blood and their relation to thyroid hormone and retinol homeostasis in humans and polar bears. Carleton University, Canada.
    51.Covaci A, Jorens P, Jacquemyn Y, Schepens P. 2002 Distribution of PCBs andorganochlorine pesticides in umbilical cord and maternal serum. Sci Total Environ 298:45-53.
    52.Dallaire F, Dewailly é, Laliberté C, Muckle G, Ayotte P. 2002. Temporal trends of organochlorine concentrations in umbilical cord blood of newborns from the lower North shore of the St. Lawrence River (Québec, Canada). Environ Health Perspect 110:835-838.
    53.Danis B, Wantier P, Dutrieux S, Flammang R, Dubois Ph, Warnau M. 2004 Contaminant levels in sediments and asteroids (Asterias rubens L., Echinodermata) from the Belgian coast and Scheldt estuary: polychlorinated biphenyls and heavy metals. Sci Total Environ 333:149-165.
    54.Darnerud PO. 1995 Bakgrund till de reviderade kostr?den. PCB och dioxiner I fisk. V?r f?da 47:10-21.
    55.Day KE, Scott IA. 1990 Use of acetylcholinesterase activity to detect sublethal toxicity in stream invertebrates exposed to low concentrations of organophosphate insecticides. Aquat Toxicol 18:101-114.
    56.De Vito MJ, Birnbaum LS, Farland WH, Gasiewicz TA. 1995 Comparisons of estinated body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals. Environ Health Perspect 103:820.
    57.De Vito MJ, Ma X, Babish JG, Menache M, Birnbaum LS. 1994 Dose response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo -p-dioxin: CYP1A1, CYP1A2,estrogen receptor and protein tyrosine phosphorylation. Toxico Appl Pharmacol 124:82.
    58.Demers A, Ayotte P, Brisson J, Dodin S, Robert J, Dewailly é. 2002 Plasma Concentrations of Polychlorinated Biphenyls and the Risk of Breast Cancer: A Congener-specific Analysis. Am J Epidemiol 155:629-635.
    59.Dewailly E, Ayotte P, Bruneau S, et al. 2000 Susceptibility to infections and immune status in Inuit infants exposed to organochlorines. Environ Health Perspect 108(3):205-211.
    60.Dluhy, RC. 2000 The adrenal cortex in hypothyroidism. In: Braverman LE, Utiger RD, ed. Werner and Ingbar's the thyroid: A fundamental and clinical text.Philadelphia, PA: Lippincott-Raven, 815-819.
    61.DoE. 1987 Summary of the ministerial declaration from the International Conference of the Protection of the North Sea. Department of the Environment, London.
    62.DoE. 1990 Summary of the ministerial declaration from the International Conference of the Protection of the North Sea. Department of the Environment, London.
    63.Donoso JA, Illanes JP, Samson F. 1977 Dimethylsulfoxide action on fast axoplasmic transport and ultrastructure of vagal axons. Brain Res 120:287-301.
    64.Drinker CK. 1937 The problem of possible systemic effects from certain chlorinated hydrocarbons. Journal of Industrial Hygiene and Toxicology 19:283-311.
    65.Duarta-Davidson R, Wilson SC, Jones KC. 1994 PCBs and other organochlorines in human tissue samples from the Welsh Population.2.Milk. Environ Pollut 84:79-87.
    66.Duarte-Davidson R, Jones KC. 1994. Polychlorinated biphenyls (PCBs) in the UK population: estimated intake, exposure and body burden. Sci Total Environ 151:131-152.
    67.Duinker JC, Schulz DE, Petrick G. 1988 Multidimensional gas chromatography with electron capture detection for the determination of toxic congeners in polychlorinated biphenyl mixtures. Anal Chem 60:478-482.
    68.Emmett EA, Maroni M, Jeffery JS, et al. 1988a Studies of transformer repair workers exposed to PCBs: II. Results of clinical laboratory investigations. Am J Ind Med 14:47-62.
    69.Emmett EA, Maroni M, Schmith JM, et al. 1988b Studies of transformer repair workers exposed to PCBs: I. Study design, PCB concentrations, questionnaire, and clinical examination results. Am J Ind Med 13:415-427.
    70.Enrique MO, Morales V, Ngoumgna E, Prescilla R, Tan E, Hernandez E, Ramirez GB, Cifra HL, Manlapaz ML. 2002 Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. Neurotoxicology 23(3):329-339.
    71.Erdogrul ?, Covaci A, Schepens P. 2005 Levels of organochlorine pesticides, polychlorinated biphenyls and polybrominated diphenyl ethers in fish species from Kahramanmaras, Turkey. Environ Int 31:703-711.
    72.Erdo?ula ?, Covaci A, Kurtul N, Schepens P. 2004 Levels of organo- halogenated persistent pollutants in human from Kahramanmaras region, Turkey. Environ Int 30: 659-666.
    73.European Commission. 2000 Reports on tasks for scientific cooperation. Assessment of dietary intake of dioxins and related PCBs by the population of EU member states.
    74.European Environment Agency. 2001 Late lessons from early warnings: the precautionary principle 1896-2000. Environmental issue report No 22. Copenhagen, Denmark.
    75.Ewald G, Larrsson P, Linge H, Okla L, Szarzi N. 1998 Biotransport of organic pollutants to an inland Alaska lake by migrating sockeye salmon (Oncorhynchus nerka). Artic 51(1):40-47.
    76.Fein GG, Jacobson JL, Jacobson SW, et al. 1984a Intrauterine exposure of humans to PCBs: Newborn effects. U.S. Environmental Protection Agency, Duluth, MN. EPA 600/53-84-060. NTIS PB84-188-887.
    77.Fein GG, Jacobson JL, Jacobson SW, et al. 1984b Prenatal exposure to polychlorinated biphenyls: Effects on birth size and gestational age. J Pediatr 105:315-320.
    78.Ferreira AM, Martins M, Vale C. 2003 Influence of diffuse sources on levels and distribution of polychlorinated biphenyls in the Guadiana River estuary, Portugal. Marine Chemistry 83:175-184.
    79.Fischbein A, Wolff MS, Lilis R, et al. 1979 Clinical findings among PCB-exposed capacitor manufacturing workers. Ann NY Acad Sci 320:703-715.
    80.Fischbein A. 1985 Liver function tests in workers with occupational exposure to polychlorinated biphenyls (PCBs): Comparison with Yusho and Yu-Cheng. Environ Health Perspect 60:145-150.
    81.Focant JF, Pirard C, Thielen C, De Pauw E. 2002 Levels and profiles of PCDDs,PCDFs and cPCBs in Belgian breast milk. Estimation of infant intake. Chemosphere 48:763-770.
    82.Frame GM, Cochran JW, Boewadt SS. 1996 Complete PCB congener distributions for 17 Aroclor mixtures determined by 3 HRGC systems optimized for comprehensive, quantitative, congener-specific analysis. J High Resol Chromatogr 19:657-668.
    83.Frame GM, Wagner RE, Carnahan JC, Brown JJF, May RJ, Smullen LA, Bedard DL. 1996 Comprehensive, quantitative, congener-specific analyses of eight Aroclors and complete PCB congener assignments on DB-1 capillary GC columns. Chemosphere 33:603-623.
    84.Frignani M, Bellucci LG, Carraro C, Russo A. 2001 Distribution of polychlorinated biphenyls in dated sediments cores from the Venice Lagoon and the industrial area of Porto Marghera. Organohalogen Compd 51:65-68.
    85.Gage JC, Holm S. 1976 The influence of molecular structure on the retention and excretion of polychlorinated biphenyls by the mouse. Toxicol Appl Pharmacol 36:555-560.
    86.Galgani F, Bocquené G. 2000 Molecular biomarkers of exposure of marine organisms to organophosphorus pesticides and carbamates. In: Lagadic, L. (Ed.), Use of Biomarkers for Environmental Quality Assessment. Elsevier Science Publisher, Amsterdam,113-137.
    87.Gevao B, Hamilton-Taylor J, Jones KC. 1998 Polychlorinated biphenyl and polycyclic aromatic hydrocarbon deposition to and exchange at the air-water interface of Esthwaite Water, a small lake in Cumbria, UK. Environ Pollut 102:63-75.
    88.Geyer HJ, Gerhard GR, Scheunert I, Kaune A, Schramm KW, Kettrup A, Zeeman M, Muir DCG, Hansen LG, Mackay D. 2000 Bioaccumulation and Occurrence od Endocrine-Disrupting Chemicals(EDCs), Persistent Organic Pollutants(POPs), and Other Organic Compounds in Fish and Other Organisms including Humans. The handbook of Environmantal Chemistry, Vol. 2 Part J Bioaccumulation. Springer-Verlag Berlin Heidelberg.
    89.Giesy JP, Kannan K. 1998 Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls(PCBs): implications for risk assessment. Crit Rev Toxicol 28(6):511-569.
    90.Goks?yr A, F?rlin L. 1992 The cytochrome P450 system in fish, aquatic toxicology and environmental monitoring. Aquat Toxicol 22:287-312.
    91.Goks?yr A. 1995 Cytochrome P450 in marine mammals: isozyme forms, catalytic functions, and physiological regulations. In: Blix, A.S., Wall?e, L., Ulltang, ?. (Eds.), Whales, seals, fish and man. Developments in marine biology 4. Elsevier, Amsterdam, 629-639.
    92.Green S, Carr JV, Palmer KA, et al. 1975 Lack of cytogenetic effects in bone marrow and spermatogonial cells in rats treated with polychlorinated biphenyls (Aroclors 1242 and 1254). Bull Environ Contam Toxicol 13:14-22.
    93.Guilhermino L, Barros B, Silva MC, Soares AMVM. 1998 Should the use of inhibition of cholinesterases as a specific biomarker for organophosphate and carbamate pesticides be questioned? Biomarkers 3:157-163.
    94.Guo LY. 1999 Human health effects from PCBs and dioxin-like chemicals in the rice-oil poisonings as compared with other exposure episodes. Organohalogen Compounds 42:241-243.
    95.Guo YL, Yu ML, Hsu CC, et al. 1999 Chloracne, goiter, arthritis, and anemia after polychlorinated biphenyl poisoning: 14-year follow-up of the Taiwan Yucheng cohort. Environ Health Perspect 107(9):715-719.
    96.Gustavsson P, Hogstedt C. 1997 A cohort study of Swedish capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Am J Ind Med 32(3):234-239.
    97.Guzzella L, Roscioli C, Viganò L, Saha M, Sarkar SK, Bhattacharya A. 2005 Evaluation of the concentration of HCH, DDT, HCB, PCB and PAH in the sediments along the lower stretch of Hugli estuary, West Bengal, northeast India. Environ Int 31:523-534.
    98.Haake JM, Safe S, Mayara K, Phillips TD. 1987 Aroclor1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol lett 38:299.
    99.Haasch ML, Graf WK, Quardokus EM, Mayer RT, Lech JJ. 1994 Use of 7-alkoxyphenoxazones, 7-alkoxycoumarins and 7-alkoxyquinolines as fluorescent substrates for rainbow trout hepatic microsomes after treatment with various inducers. Biochem Pharmacol 47: 893-903.
    100.Habig WH, Pabst MJ, Jakoby WB. 1974 Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 246:7130-7139.
    101.Hagmar L, Hallberg T, Leja M, et al. 1995 High consumption of fatty fish from the Baltic Sea is associated with changes in human lymphocyte levels. Toxicol Lett 77:335-342.
    102.Hahn ME, Woodward BL, Stegeman JJ, Kennedy SW. 1996 Rapid assessment of induced cytochrome P4501A(CYP1A) protein and catalytic activity in fish hepatoma cells grown in multi-well plates: Response to TCDD, TCDF, and two planar PCBs. Environ Toxicol Chem 15:582-591.
    103.Hammae T. 1992 PCB i fogmassor. Rapport, L?nsstyrelsen i Kalmar l?n [in Swedish].
    104.Hanberg A, Strahlberg M, Georgellis A, de Wit C, Ahlborg U G. 1991 Swedish dioxin survey: envalution of the 4IIE bioassay for screening environmental samples for dioxin-like enzyme induction. Pharmacol Toxicol 69:442-449.
    105.Haraguchi K, Koga N, Yoshimura H, et al. 1999 Comparative metabolism of polychlorinated biphenyls (Kanechlor-500) in rats, hamsters and guinea pigs. Organohalogen Compounds 42:177-179.
    106.Hayes MA. 1987 Carcinogenic and mutagenic effects of PCBs. In: Safe S, Hytzinger O, eds. Environmental toxin series. Vol 1: Polychlorinated biphenyls (PCBs: Mammalian and environmental toxicology). Heidelberg: Springer-Verlag, 77-95.
    107.Hicks C, Dietmar R, Eugster M. 2005 The recycling and disposal of electrical and electronic waste in China-legislative and market responses. Environmental Impact Assessment Review 25:459-471.
    108.Hinck JE, Schmitt CJ, Blazer VS, Denslow ND, Bartish TM, Anderson PJ, Coyle JJ, Dethloff GM, Tillitt DE. 2005 Environmental contaminants and biomarkerresponses in fish from the Columbia River and its tributaries: Spatial and temporal trends. Sci Total Environ (in press).
    109.Holden AV. 1970 Monitoring organochlorine contamination of the marine environment by the analysis of residues in seals. Marine pollution and sea life 266-272. Fishing News Books Ltd, England.
    110.Hong SH, Yim UH, Shim WJ, Li DH, Oh JR. 2006 Nationwide monitoring of polychlorinated biphenyls and organochlorine pesticides in sediments from coastal environment of Korea. Chemosphere (in press).
    111.Hong ZY, Günter M, Randow FFE. 2002 Meconium: a matrix reflecting potential fetal exposure to organochlorine pesticides and its metabolites. Ecotoxicol Environ Saf 51:60-64.
    112.Honkakoski P, Moore R, Washburn K, Negishi M. 1998a Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol Pharmacol 53:597-601.
    113.Honkakoski P, Zelko I, Sueyoshi T, Negishi M. 1998b The orphan nuclear receptor CAR-retinoid X receptor heterodimer activates the phenobarbital- responsive enhancer module ofthe CYP2B gene. Mol Cell Biol 18:5652-5658.
    114.Hoppin JA, Tolbert PE, Holly EA, Brock JW, Korrick SA, Altshul LM, Zhang RH, Bracci PM, Burse VW, Needham LL. 2000 Pancreatic Cancer and Serum Organochlorine Levels. Cancer Epidemiology, Biomarkers & Prevention 9:199-205.
    115.Huang S, Gibson GG. 1992 Species and congener specific induction of hepatic cytochrome P4504A by polychlorinated biphenyls. Biochem Pharmacol 43:637-639.
    116.Huisman M, Koopman-Esseboom C, Fidler V, Hadders-Algra M, van der Paauw C, Tuinstra L, Weisglas-Kuperus N, Sauer P, Touwen B, Boersma R. 1995a Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development. Early Hum Dev 41:111-127.
    117.Huisman M, Koopman-Esseboom C, Lanting CI, et al. 1995b Neurological condition in 18-month-old children perinatally exposed to polychlorinatedbiphenyls and dioxins. Early Hum Dev 43:165-176
    118.Huisman M. 1996 Effects of early infant nutrition and perinatal exposure to PCBs and dioxins on neurological development: A study of breast-fed and formula-fed infants, Dissertation (ISBN 90-3670688-2), University of Groningen, Groningen.
    119.Hutzinger O, Safe S, Zitko V, eds. 1974 The chemistry of PCBs. Boca Raton, FL: CRC Press.
    120.Huuskonen S, Lindstr?m-Sepp? P, Koponen K, Roy S. 1996 Effects of non-ortho-substituted polychlorinated biphenyls (Congeners 77 and 126) on cytochrome P4501A and conjugation activities in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol 113C (2):205-213.
    121.IUPAC/ISO/AOAC INTERNATIONAL/EURACHEM. 1999 Harmonised Guidelines for the Use of Recovery Information in the Analytical Measurement.
    122.Iwata H, Yoshinari K, Negishi M, Stegeman JJ. 2002 Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops). Comp Biochem Physiol C 131:501-510.
    123.Jacobson JL, Fein GG, Jacobson SW, Schwartz PM, Dowler JK. 1984 The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls across human placenta and into maternal milk. Am J Public Health 74(4): 378-379.
    124.Jacobson JL, Jacobson SW. 1993 A 4-year followup study of children born to consumers of Lake Michigan fish. J Great Lakes Res 19(4):776 -783.
    125.James RC, Busch H, Tamburro CH, et al. 1993 Polychlorinated biphenyl exposure and human disease. J Occup Med 35:136-148.
    126.Jensen S, Johnels AG, Olsson M, Otterlind G. 1969 DDT and PCB in marine animals from Swedish waters. Nature 224:247.
    127.Johansen HR, Becher G, Polder A, et al. 1994 Congener-specific determination of polychlorinated biphenyls and organochlorine pesticides in human milk from Norwegian mothers living in Oslo. J Toxicol Environ Health 42(2):157-171.
    128.Johansen HR. 1996 PCDDs, PCDFs and PCB in human blood in relation to consumption of crabs from a contaminated fjord area in Norway. Environ health perspect 104:756-764.
    129.Kannan N, Tanaba S, Ono M, Tatsukawa R. 1989 Critical evaluatiuon of polychlorinated biphenyls toxicity in terretrial and marine mammals: increasing impact of non-ortho and mono-ortho coplanar polychlorinated biphenyls from land to ocean. Arch Environ Contam Toxicol 18:850.
    130.Kato N, Mochizuki S, Kawai K, et al. 1982a Effect of dietary level of sulfur-containing amino acids on liver drug-metabolizing enzymes, serum cholesterol and urinary ascorbic acid in rats fed PCB. J Nutr 112:848-854.
    131.Kennedy SW, Fox GA, Jones SP, Trudeau SF. 2003 Hepatic EROD activity is not a useful biomarker of polychlorinated biphenyl exposure in the adult herring gull (Larus argentatus). Ecotoxicology 12:153-161.
    132.Kim MK, Kim S, Yun S, Lee M, Cho B, Park J, Son S, Kim O. 2004 Comparison of seven indicator PCBs and three coplanar PCBs in beef, pork, and chicken fat. Chemosphere 54:1533-1538.
    133.Kimbrough RD, Doemland ML, LeVois ME. 1999 Mortality in male and female capacitor workers exposed to polychlorinated biphenyls. J Occup Environ Med 41(3):161-171.
    134.Klamer HJC, Leonards PEG, Lamoree MH, Villerius LA, ?kerman JE, Bakker JF. 2005 A chemical and toxicological profile of Dutch North Sea surface sediments. Chemosphere 581:1579-1587.
    135.Klecka G, et al. 2000 Evaluation of persistence and long-range transport of organic chemicals in the environment. (Society of Environmental Toxicology and Chemistry (SETAC). Special Publication Series, Pensacola, FL.
    136.Kleinow KM, Haasch ML, Williams DE, Lech JJ. 1990 A comparison of hepatic P450 induction in rat and trout (Oncorhynchus mykiss): delineation ofthe site of resistance off ish to phenobarbital-type inducers. Comp Biochem Physiol 96C:259-270.
    137.Kling D, Kunkle J, Roller AS, et al. 1978 Polychlorinated biphenyls: In vivoand in vitro modifications of cholesterol and fatty acid biosynthesis. J Environ Pathol Toxicol 1:813-828.
    138.Klotz A, Stegeman J, Woodin B, Snowberger E, Thomas P, Walsh C. 1986 Cytochrome P450 isozymes from the marine teleost Stenotomus chrysops: their roles in steroid hydroxylation and the influence of cytochrome b5. Arch Biochem Biophys 249:326-338.
    139.Kodavanti PRS, Kannan N, Yamashita N, Derr-Yellin EC, Ward TR, Burgin DE, Tilson HA, Birnbaum LS. 2001 Differential Effects of Two Lots of Aroclor 1254: Congener-Specific Analysis and Neurochemical End Points. Environ Health Perspect 109:1153-1161.
    140.Kono TK, Yamana Y. 1979 Ocular symptoms of oil disease patients (report 4): Investigation 10 years after onset. Fukuoka Igaku Zasshi 70:181-186. (Japanese)
    141.Koopman-Esseboom C, Huisman M, Weisglas-Kuperus N, et al. 1994 PCB and dioxin levels in plasma and human milk of 418 Dutch women and their infants. Predictive value of PCB congener levels in maternal plasma for fetal and infant’s exposure to PCBs and dioxins. Chemosphere 28(9):1721-1732.
    142.Koopman-Esseboom C, Weisglas-Kuperus N, de Ridder MAJ, et al. 1996 Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development. Pediatrics 97:700-706.
    143.Koponen K, Lindstr?m-Sepp? P, Koponen K. 2000 Accumulation pattern and biotransformation enzyme induction in rainbow trout embryos exposed to sublethal aqueous concentrations of 3,3’,4,4’-tetrachlorobiphenyl. Chemosphere 40:245-253.
    144.Korrick SA, Altshul L. 1998 High breast milk levels of Polychlorinated Biphenyls (PCBs) among four women living adjacent to a PCB-Contaminated waste site. Environ Health Perspect 106: 513-518.
    145.Kreiss K, Zack MM, Kimbrough RD, et al. 1981 Association of blood pressure and polychlorinated biphenyl levels. J Am Med Assoc 245:2505-2509.
    146.Krümmel E, Macdonald R, Kimpe LE, Gregory-Eaves I, Smol JP, Finney B, Blais JM. 2003 Delivery of pollutants by spawning salmon. Nature (Lond.)425:255-256.
    147.Kunisue T, Someya M, Kayama F, Jin Y, Tanabe S. 2004 Persistent organo- chlorines in human breast milk collected from primiparae in Dalian and Shenyang, China. Environ Pollut 131:381-392.
    148.Kuratsune M. 1989 Yusho, with reference to Yu-Cheng. In: Kimbrough RD, Jensen AA, eds. Halogenated biphenyls, terphenyls, naphthalenes, dibenzo- dioxins and related products. 2nd ed. Amsterdam, The Netherlands: Elsevier Science Publishers, 381-400.
    149.Kusuda M. 1971 A study on the sexual functions of women suffering from rice-bran oil poisoning. Sanka to Fujinka 38:1062-1072.
    150.Lai KP, Li W, Xu Y, Wong MH, Wong Chris KC. 2004 Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou. Environ Res 96:88-94.
    151.Landrigan PJ, Sonawane B, Mattison D, McCally M, Garg A. 2002 Chemical contaminants in breast milk and their impacts on children’s health: an overview. Environ Health Perspect 110:313-315.
    152.Langer P, Tajtakova M, Fodor G, et al. 1998 Increased thyroid volume and prevalence of thyroid disorders in an area heavily polluted by polychlorinated biphenyls. Eur J Endocrinol 139:402-409.
    153.Lanting CI, Patandin S, Fidler V, et al. 1998 Neurological condition in 42-month-old children in relation to pre- and postnatal exposure to polychlorinated biphenyls and dioxins. Early Hum Dev 50:283-292.
    154.Lanting CI. 1999 Effects of perinatal PCB and dioxin exposure and early feeding on child development, Dissertation (ISBN90-3671002-2), University of Groningen, Groningen.
    155.Lavado R, Ure?a R, Martin-Skilton R, Torreblanca A, Ramo J, Raldúa D, Porte C. 2006 The combined use of chemical and biochemical markers to assess water quality along the Ebro River. Environ Pollut 139:330-339.
    156.Lawrence GS,Gobas FAPC. 1997 A pharmacokinetic analysis of interspecies extrapolation in dioxin risk addeessment. Chemosphere 35:427.
    157.Lawton RW, Ross MR, Feingold J, et al. 1985 Effects of PCB exposure on biochemical and hematological findings in capacitor workers. Environ Health Perspect 60:165-184.
    158.Lee L, Kang SA, Lee HO. 2001 Effect of supplementation of vitamin E and vitamin C on brain acetylcholinesterase activity and neurotransmitter concentrations in rats treated with scopolamine, an inducer of dementia. J Nutr Sci Vitaminol 47:323-328.
    159.Lee RGM, Hung H, Mackay D, Jones KC. 1998 Measurement and modelling of the diurnal cycling of atmospheric PCBs and PAHs. Environ Sci Technol 32:2172-2179.
    160.Li W, Wu WZ, Barbara RB, Schramm K-W, Kettrup A. 1999 A new enzyme immunoassay for PCDD/F TEQ screening environmental samples: comparison to micro-EROD assay and to chemical analysis. Chemosphere 38(14):3313- 3318.
    161.Liem AKD, F?rst P, Rappe C. 2000 Exposure of populations to dioxins and related compounds. Food Addit Contam 17:241-259.
    162.Liem AKD. 1999 Basic aspects of methods for the determination of dioxins and PCBs in foodstuffs and human tissues. Trends in Analytical Chemistry 18(6): 429-439.
    163.Liu X, Tanaka M, Matsui Y. 2006 Electrical and electronic waste management in China: progress and the barriers to overcome. Waste Manage Res 24:92-101.
    164.Lonky E, Reihman J, Darvill T, et al. 1996 Neonatal behavioral assessment scale performance in humans influenced by maternal consumption of environmentally contaminated Lake Ontario fish. J Great Lakes Res 22(2):198-212.
    165.Lord H, Pawliszyn J. 2000 Evolution of solid-phase microextraction technology Journal of Chromatography A 885:153-193.
    166.Loved AA, Foxall CD, Chad CS, Chewe D. 1998 PCB and PCDD/DF concentrations in egg and poultry meat samples from known urban and rural locations in Wales and England. Chemosphere 31(9-12):1671-1685.
    167.Lu YC, Wu YC. 1985 Clinical findings and immunological abnormalities in Yu-Cheng patients. Environ Health Perspect 59:17-29.
    168.Ludke LK, Hill EF, Dieteer MP. 1975 Cholinesterase (ChE) response and related mortality among birds fed ChE inhibitors. Environ Contam Toxicol 3:1-21.
    169.Lundén ?, Norén K. 1998 Polychlorinated naphthalenes and other organochlorine contaminants in Swedish human milk, 1972–1992. Arch Environ Contam Toxicol 34:414-423.
    170.Lutter C, Lyengar V, Barnes R, Chuvakova T, Kazbekova G, Sharmanov T. 1998 Breast milk contamination in Kazakhstan: implications for infant feeding. Chemosphere 31(9-12):1761-1772.
    171.Machala M, Nezveda K, Pet?ivalsky M, Jaro?ová A, Pia?ka V, Svobodová Z. 1997 Monooxygenase activities in carp as biochemical markers of pollution by polycyclic and polyhalogenated aromatic hydrocarbons: choice of substrates and effects of temperature, gender and capture stress. Aquat Toxicol 37:113-123.
    172.Maroni M, Columbi A, Arbosti G, et al. 1981a Occupational exposure to polychlorinated biphenyls in electrical workers. II Health effects. Br J Ind Med 38:55-60.
    173.Maroni M, Columbi A, Arbosti G, et al. 1981b Occupational exposure to polychlorinated biphenyls in electrical workers. I Environmental and blood polychlorinated biphenyls concentrations. Br J Ind Med 38:49-54.
    174.Marvin CH, Painter S, Charlton MN, Fox ME, Lina Thiessen PA. 2004 Trends in spatial and temporal levels of persistent organic pollutants in Lake Erie sediments. Chemosphere 54:33-40.
    175.Masuda Y. 1994 The Yusho rice oil poisoning incident’ in Schecter, A. (ed.) Dioxins and health 633-659. PlenumPress, New York and London.
    176.Matsui M, Kashima Y, Kawano M, Matsuda M, Ambe K, Wakimoto T, Doi R. 2003 Dioxin-like potencies and extractable organohalogens (EOX) in medical, municipal and domestic waste incinerator ashes in Japan. Chemosphere 53:971-980.
    177.Matthews HB, Anderson MW. 1975 Effect of chlorination on the distribution and excretion of polychlorinated biphenyls. Drug Metab Dispos 3:371-380.
    178.Matthews HB, Dedrick RL. 1984 Pharmacokinetics of PCBs. Annu Rev Pharmacol Toxicol 24:85-103.
    179.Matthews HB. 1982 Aryl halides. In: Jakoby WB, Bend JR, Caldwell J, eds. Metabolic basis of detoxification. Metabolism of functional groups. New York: Academic Press, 51-68.
    180.Maynard E, Amoroso LP, Oh W. 1991 Meconium for drug testing. Am J Dis Child 45:650-653.
    181.Miller DB, Gray LE Jr, Andrews JE, et al. 1993 Repeated exposure to the polychlorinated biphenyl (Aroclor 1254) elevates the basal serum levels of corticosterone but does not affect the stress-induced rise. Toxicology 81(3):217-222.
    182.Mochizuki H, Oda H, Yokogoshi H. 2000 Dietary taurine alters ascorbic acid metabolism in rats fed diets containing polychlorinated biphenyls. J Nutr 130:873-876.
    183.Moilanen R, Pyysalo H, Kumpulainen J. 1986 Average total dietary intakes of organochlorine compounds from the Finnish diet. Zeitung fur Lebensmittel Untersuchung und Forschung 182:484-488.
    184.Mort I, Piazza R, Benedetti, Gambaro A, Barbante C, Cescon P. 2001 Determination of polychlorobiphenyls in Venice Lagoon sediments. Chemosphere 43:559-565.
    185.Muckle G, Ayotte P, Dewailly é, Jacobson SW, Jacobson JL. 2001 Prenatal exposure of the Northern Québec Inuit infants to environmental contaminants. Environ Health Perspect 109:1291-1299.
    186.Mueller T, Vernier P, Wullimann MF. 2004 The adult central nervous cholinergic system of a neurogenetic model animal, the zebrafish Danio rerio. Brain res 1011(2):156-169.
    187.Mullin MD, Pochini CM, McCrindle S, Romkes M, Safe S, Safe L. 1984 High-resolution PCB analysis: the synthesis and chromatographic properties ofall 209 PCB congeners. Environ Sci Technol 18:468.
    188.Murugesan P, Senthilkumar J, Balasubramanian K, Aruldhas MM, Arunakaran J. 2005 Impact of polychlorinated biphenyl Aroclor 1254 on testicular antioxidant system in adult rats. Human Exp Toxicol 24:61-66.
    189.Muthuvel R, Venkataraman P, Krishnamoorthy G, Gunadharini DN, Kanagaraj P, Stanley AJ, Srinivasan N, Balasubramanian K, Aruldhas MM, Arunakaran J. 2006 Antioxidant effect of ascorbic acid on PCB (Aroclor 1254) induced oxidative stress in hypothalamus of albino rats. Clin Chim Acta 365:297-303.
    190.Nakanishi Y, Shigematsu N, Kurita Y, et al. 1985 Respiratory involvement and immune status in Yusho patients. Environ Health Perspect 59:31-36.
    191.Neubert D, Golor G, Neubert R. 1992 TCDD-toxicity equivalencies for PCDD/PCDF congeners: prerequisites and limitations. Chemosphere 25:65.
    192.Neumann HG.. 1996 Toxic equivalence factors, problems and limitation. Food Chem Toxicol 34:1045.
    193.Newman JW, Becker JS, Blodina G, Tjeerdema RS. 1998 Quantitation of Aroclors using congener-specific results. Environ Toxicol Chem 11:2159-2167.
    194.Newsome WH, Davies D, Doucet J. 1995 PCB and organochlorine pesticides in Canadian human milk--1992. Chemosphere 30:2143-2153.
    195.Ngui JS, Bandiera SM. 1999 Induction of hepatic CYP2B is more sensitive indicator of exposure to Aroclor 1260 than CYP1A in male rats. Toxicol Appl Pharmacol 161:160-70.
    196.NIOSH. 1990 NIOSH pocket guide to chemical hazards. National Institute for Occupational Safety and Health, Cincinnati, OH.
    197.Norén K, Lundén A. 1991 Trend studies of polychlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans in human milk. Chemesphere 23(11-12):1895-1901
    198.Norén K, Meironyt D. 2000 Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 40:1111-1123.
    199.OECD. 1987 Decision-recommendation of the Council concerning furthermeasures for the protection of the environment by control of polychlorinated biphenyls, C(87) 2 (Final).
    200.OECD. 1973 Decision-recommendation of the Council on Protection of the Environment by control of polychlorinated biphenyls, C(73) 1 (Final).
    201.?rn S, Andersson PL, F?rlin L, Tysklind M, Norrgren L. 1998 The impact on reproduction of an orally administered mixture of selected PCBs in zebrafish (Danio rerio). Arch Environ Contam Toxicol 35:52-57.
    202.Ostrea Jr, EM, Brady M, Gause S, Raymundo A. 1992 Drug screening of newborn infants by meconium analysis: a large scale prospective, epidemiologic study. Pediatrics 89:107-113.
    203.Ostrea Jr, EM, Morales V, Ngoumgna E, Prescilla R, Tan E, Hernandez E, Ramirez GB, Cifra HL, Manlapaz ML. 2002 Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. NeuroToxicology 23:329-339.
    204.Ostrea Jr, EM, Ngoumgna E, Alano M, Tan E, Hernandez E, Ramirez GB, Manlapaz M. 1998 Biomarkers of fetal exposure to pesticides and their correlates to outcome. Pediatr Res 43:224A.
    205.Ouw HK, Simpson GR, Siyali DS. 1976 Use and health effects of Aroclor 1242, a polychlorinated biphenyl, in an electrical industry. Arch Environ Health 31:189-194.
    206.Patandin S, Dagnelie PC, Mulder PGH, Op de Coul E, van der Veen JE, Weisglas- Kuperus N, Sauer PJJ. 1999Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood: a comparison between breast-feeding, toddler, and long-term exposure. Environ Health Perspect 107:45-51.
    207.Patandin S, Lanting C, Mulder P, Boersma E, Sauer P, Weisglas-Kuperus N. 1999 Effects of environmental exposure to Polychlorinated Biphenyls and Dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr 134 (1):33-41.
    208.Patandin S, Lanting CI, Mulder PGH, et al. 1999 Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutchchildren at 42 months of age. J Pediatr 134:33-41.
    209.Pellizzari E, Moseley MA, Cooper SD. 1985 Recent advances in the analysis of polychlorinated biphenyls in environmental and biological media. J Chromatogr 334:227.
    210.Pérez López M, Nóvoa Vali?as MC, Melgar Riol MJ. 2002 Induction of cytosolic Glutathione S-transferases from Atlantic eel (Anguilla anguilla) after intraperitoneal treatment with polychlorinated biphenyls. Sci Total Environ 297: 141-151.
    211.Pfeifer S, Schiedek D, Dippner JW. 2005 Effect of temperature and salinity on acetylcholinesterase activity, a common pollution biomarker, in Mytilus sp. from the south-western Baltic Sea. Journal of Experimental Marine Biology and Ecology 320:93-103.
    212.Polder A, Odland JO, Tkachev A, F?reid S, Savinova TN, Skaare JU. 2003 Geographic variation of chlorinated pesticides, toxaphenes and PCBs in human milk from sub-arctic and arctic locations in Russia. Sci Total Environ 306: 179-195.
    213.Poon BHT, Leung CKM, Wong CKC, Wong MH. 2005 Polychlorinated biphenyls and organochlorine pesticides in human adipose tissue and breast milk collected in Hong Kong. Arch Environ Contam Toxicol 49:274-282.
    214.Preston BD, Miller JA, Miller EC. 1984 Reactions of 2,2',5,5'-tetrachlorobiphenyl -3,4-oxide with methionine, cysteine and glutathione in relation to the formation of methylthio-metabolites of 2,2',5,5'-tetrachlorobiphenyl in the rat and mouse. Chem-Biol Ineract 50:289-312.
    215.Putzrath RM. 1997 Estimating relative potency for receptor-mediated toxicity: Reevaluating the toxicity equivalence factor (TEF) model. Reg Toxico Pharmacol 25:68.
    216.Ramachandran SD, Hodson PV, Khan CW, Lee K. 2004 Oil dispersant increases PAH uptake by fish exposed to crude oil. Ecotoxicol Environ Saf 59:300-308.
    217.Ramirez GB, Cruz MCV, Pagulayan O, Ostrea E, Dalisay C. 2000 The TagumStudy I: Analysis and clinical correlates of mercury in maternal and cord blood, breast milk, meconium, and infants’ hair. Pediatrics 106:774-781.
    218.Rao CV, Banerji SA. 1993 Effect of polychlorinated biphenyls (Aroclor 1260) on histology of adrenal of rats. J Environ Biol 14:1-6.
    219.Rawn DFK, Forsyth DS, Ryan JJ, Breakell K, Verigin V, Nicolidakis H, Hayward, Laffey SP, Conacher HBS. 2006 PCB, PCDD and PCDF residues in fin and non-fin fish products from the Canadian retail market 2002. Sci Total Environ 359:101-110.
    220.Rice CD, Roszell LE, Banes MM, Arnold RE. 1998 Effects of Dietary PCBs and Nonyl-phenol on Immune function and CYPlA Activity in Channel Catfish, Ictalurus punctatus. Mar Environ Res 46 (1-5):351-354.
    221.Rice RH, Cohen DE. 1996 Toxic responses of the skin. In: Klaassen CD, ed. Cassarett and Doull’s toxicology: The basic science of poisons. New York, NY: McGraw-Hill, 529-546.
    222.Robertson LW, Gupta RC. 2000 Metabolism of polychlorinated biphenyls (PCBs) generates electrophiles and reactive oxygen species that damage DNA. In: Williams GM, Aruoma OI, eds. Molecular drug metabolism and toxicology. OICA International, 1-19.
    223.Rogan WJ, Gladen BC, McKinney JD, Carreras N, Hardy P, Thullen J, Tingelstad J, Tully M. 1986 Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr 109:335-341.
    224.Rogan WJ, Gladen BC. 1991 PCBs and DDE and child development at 18 and 24 months. Ann Epidemiol 1:407-413.
    225.Rogan WJ, Gladen BC. 1992 Neurotoxicity of PCBs. Neurotoxicology 13:27 -39.
    226.Rogan WJ. 1989 Yu-Cheng. In: Kimbrough RD, Jensen AA, eds. Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products. 2nd ed. Amsterdam, The Netherlands: Elsevier Science Publishers, 401-415.
    227.Ruus A, Green NW, Maage A, Skei J. 2006 PCB-containing paint and plaster caused extreme PCB-concentrations in biota from the S?fjord (WesternNorway)-A case study. Mar Pollut Bull 52:100-103.
    228.Ruus A, Sandvil M, Ugland KI, Skaare JU. 2002 Factors influencing activities of biotransformation enzymes, concentrations and compositional patterns of organochlorine contaminants in members of a marine food web. Aquat Toxicol 61:73-87.
    229.Rylander L and Hagmar L. 1995 Mortality and cancer incidence among women with a high consumption of fatty fish contaminated with persistent organochlorine compounds. Scand J Work Environ Health 21(6):419-426.
    230.Safe S, Bandiera S, Sawyer T, et al. 1985 PCBs: Structure-function relationships and mechanism of action. Environ Health Perspect 60:47-56.
    231.Safe S, Mullin M, Safe L, Pochini C, McCrindle S, Romkes M. 1983 High resolution PCB analysis, in Physical Behavior of PCBs in the Great Lakes, Mackay D, Paterson S, Eisenreich SJ, Simons MS, Eds, Ann Arbor Science, Ann Arbor MI:1.
    232.Safe S, Safe L, Mullin M. 1987 Polychlorinated biphenyls: environmental occurrence and analysis in Polychlorinated biphenyls (PCBs): Msmmalian and Environmental Toxicology, Environmental Toxin Series, Springer-Verlag, Heidelberg 1.
    233.Safe S. 1987 Determination of 2,3,7,8-TCDD toxic equivalent factors (TEFs): support for the use of in the vitro AHH induction assay. Chemosphere 16: 791-802.
    234.Safe S. 1990 Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 21:51-88.
    235.Safe S. 1993 Toxicology structure-function relationships, human and environmental health impacts of polychlorinated biphenyls (PCBs): progress and problems. Environ Health Perspect 101:317-322.
    236.Safe S. 1994 Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit RevToxicol 24(2):87-149.
    237.Safe S. 1987 Determination of 2,3,7,8-TCDD toxic equivalent factor(TEFs): support for the use of in the vitro AHH induction assay. Chemosphere 16:791-802.
    238.Sala M, Ribas-Fitó N, Cardo E, de Muga ME, Marco E, Mazón C, Verdú A, Grimact JO, Sunyer J. 2001 Levels of hexachlorobenzene and other organochlorine compounds in cord blood: exposure across placenta. Chemosphere 43:895-901.
    239.Sanders OT, Zepp RL, Kirkpatrick RL. 1974 Effect of PCB ingestion on sleeping times, organ weights, food consumption, serum corticosterone and survival of albino mice. Bull Environ Contam Toxicol 12:394-399.
    240.Sawyer T, Safe S. 1982 PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin-O-deethylase enzyme activities in rat hepatoma cells. Toxicol Lett 13:87-94.
    241.Schade G, Heinzow B. 1998 Organochlorine pesticides and polychlorinated biphenyls in human milk of mothers living in northern Germany: Current extent of contamination, time trend from 1986 to 1997 and factors that influence the levels of contamination. Sci Total Environ 215:31-39.
    242.Schantz SL, Widholm JJ, Rice DC. 2003 Effects of PCB exposure on neuropsychological function in children. Eviron Health Perspect 111:357-376.
    243.Schmidt H, Schultz G. 1881 Patent formanufactureofpentachlorobiphenyl. Ann 207:338.
    244.Schmidt K, Staaks GBO, Pflugmacher S, Steinberg CEW. 2005 Impact of PCB mixture (Aroclor 1254) and TBT and a mixture of both on swimming behavior, body growth and enzymatic biotransformation activities (GST) of young carp (Cyprinus carpio). Aquat Toxicol 71:49-59.
    245.Schmitz HJ, Hagenmaier A, Hagenmaier HP, Bock KW, Schrenk D. 1995. Potency of mixtures of polychlorinated biphenyls as inducers of dioxin receptor-regulated CYP1A activity in rat hepatocytes and H4IIE cells. Toxicology 99:47-54.
    246.Schultz DE, Patrick G, Duinkeyr JC. 1989 Complete characterization of polychlorinated biphenyl congeners in commercial Aroclor and Clophen mixtures by multidimensional gas chromatography-electron capture detection. Environ Sci Technol 23:852-859.
    247.Seegal RF. 1998 Neurochemical effects of co-Planar and non-coplanar Polychlorinated Biphenyls. Neurotoxicol Teratol 20(3):349-350.
    248.Seegal RF. 1999 Are PCBs the Major Neurotoxicant in Great Lakes Salmon? Environ Res 80:38-45.
    249.She J, Petreas MX, Visita P, McKinney M, Sy FJ, Winkler JJ, Hooper K, Stephens RD. 1998 Congener-specific analisis of PCBs in human milk from Kazakhstan. Chemosphere 31(3):431-442.
    250.Shigematsu N, Norimatsu Y, Ishibashi T, et al. 1971 Clinical and experimental studies on respiratory involvement in chlorobiphenyls poisoning. Fukuoka Ishi 62(1):150-156.
    251.Silberhorn EM, Glauert HP, Robertson LW. 1990 Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit Rev Toxicol 20:440-496.
    252.Skaare JU, Tuveng JM, Sande HA. 1988 Organochlorine pesticides and polychlorinated biphenyls in materal adipose tissue, blood, milk, and blood from mothers and their infants living in Norway. Arch Environ Contam Toxicol 17(1):55-63.
    253.Smith AB, Schloemer J, Lowry LK, et al. 1982 Metabolic and health consequences of occupational exposure to polychlorinated biphenyls. Br J Ind Med 39:361-369.
    254.Smith LM, Schwartz TR, Feltz K, Kubiak TJ. 1990 Determination and occurrence of AHH-active polychlorinated biphenyls, 2,3,7,8-tetrachloro -p-dioxin and 2,3,7,8-tetrachlorodibenzofuran in Lake Michigan sediment and biota. The Question of Their Relative Toxicological Significance. Chemosphere 21:1063-1085.
    255.Soechitram SD, Athanasiadou M, Hovander L, Bergman ?, Sauer PJJ. 2004 Fetal exposure to PCBs and their hydroxylated metabolites in a Dutch cohort.Environ Health Perspect 112:1208-1212.
    256.Stegeman JJ, Woodin BR, Waxman DJ. 1990a Structual relatedness of mammalian cytochromes P450 IIB and cytochrome P450 B from the marine fish scup (Stenotomus chrysops). FASEB J 4:A739.
    257.Stegeman JJ, Woodlin BR, Smolowitz RM. 1990b Structure, function and regulation of cytochrome P450 forms in fish. Biochem Sot Trans 18:19-21.
    258.Stewart P, Darvill T, Lonky E, Reihman J, Pagano J, Bush B. 1999 Assessment of Prenatal Exposure to PCBs from Maternal Consumption of Great Lakes Fish: An Analysis of PCB Pattern and Concentration. Environ Res 80:87-96.
    259.Stewart P, Pagano J, Sargent D, et al. 2000 Effects of Great Lakes fish consumption on brain PCB pattern, concentration, and progressive-ratio performance. Environ Res 82:18-32.
    260.Stewart P, Reihman J, Lonky E, Darvill T, Pagano J. 2000 Prenatal PCB exposure and neonatal behavioral assessment scale (NBAS) performance. Neurotoxicol Teratol 22:21-29.
    261.Straus DL, Schlenk D, Chambers JE. 2000 Hepatic microsomal desulfuration and dearylation of chlorpyrifos and parathion in fingerling channel catfish: lack of effect from Aroclor 1254. Aquat Toxicol 50:141-149.
    262.Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M. 1999 The repressed nuclear receptor CAR responds tophenobarbital in activating the human CYP2B6 gene. J Biol Chem 274:6043-6046.
    263.Svensson BG, Hallberg T, Nilsson A, et al. 1994 Parameters of immunological competence in subjects with high consumption of fish contaminated with persistent organochlorine compounds. Int Arch Occup Environ Health 65(6):351 -358.
    264.Svensson BG. 1991 Exposure to dioxins and dibenzofurans through consumption of fish. New England journal of medicine 324:8-12.
    265.Tanaba S, Kannan N, Ono M, Wakimoto T, Tatsukawa R. 1987 Method for the determination of three toxic non-ortho chlorines substituted coplanar PCBs in environmental samples at part-per-trillion level. Int J Environ Anal Chem 29:199.
    266.Tanaba S, Tanaka H, Tatsukawa R. 1984 Polychlorobiphenyls, DDT, and hexachlorocyclohexane isomers in the western North Pacific ecosystem. Arch Environ Contam Toxicol 13:731-738.
    267.Tanabe S, Iwata H, Tatsukawa R. 1994 Global contamination by persistent organochlorines and their ecotoxicological impact on marine mammals. Sci Total Environ 154:163-177.
    268.Tanabe S, Kannan N, Subramanian A, et al. 1987 Highly toxic coplanar PCBs: Occurrence, source, persistency and toxic implications to wildlife and humans. Environ Pollut 47:147-163.
    269.Tanabe S, Kannan N, Wakimoto T, et al. 1989 Isomer-specific determination and toxic evaluation of potentially hazardous coplanar PCBs, dibenzofurans and dioxins in the tissues of "Yusho" PCB poisoning victim and in the causal oil. Toxicol Environ Chem 24:215-231.
    270.Taylor PR, Stelma JM, Lawrence CE. 1989 The relation of polychlorinated biphenyls to birth weight and gestational age in the offspring of occupationally exposed mothers. Am J Epidemiol 129:395-406.
    271.Ten Tusscher GW, Koppe JG. 2004 Perinatal dioxin exposure and later effects-a review. Chemosphere 54:1329-1336.
    272.Till M, Behnisch P, Hagenmaier H, Bock KW, Schrenk D. 1997 Dioxin-like components in incinerator fly ash: a comparison between chemical analysis data and results from a cell culture bioassay. Environ Health Perspect 105:1326- 1332.
    273.Tillitt DE, Ankley GT, Giesy JP. 1991 Characterisation of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar halogenated hydrocarbons in environmental samples. Environ Sci Technol 25:87-92.
    274.Tilson HA, Kodavanti PRS, Mundy WR, Bushnell PJ. 1998 Neurotoxicity of environmental chemicals and their mechanism of action. Toxicol Lett 102-103:631-635.
    275.Timchalk C, Poet TS, Kousba AA. 2006 Age-dependent pharmacokinetic andpharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos. Toxicology 220:13-25.
    276.Toft G, Hagmar L, Giwercman A, Bonde JP. 2004 Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reproductive Toxicology 19:5-26.
    277.Treon JF, Cleveland FP, Cappel JW, et al. 1956 The toxicity of the vapours of Aroclor 1242 and Aroclor1254. Am Ind Hyg Assoc Q 17:204-213.
    278.Troxel CM, Buhler DR, Hendricks JD, Bailey GS. 1997 CYP1A Induction by β-Naphthoflavone, Aroclor 1254, and 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Its Influence on Aflatoxin B1 Metabolism and DNA Adduction in Zebrafish (Danio rerio). Toxicol appl pharmacol 146:69-78.
    279.Tuinstra LGMTh, Huisman M, Boersma ER. 1994 The Dutch PCB/Dioxin study: contents of dioxins, planar and other PCBs in human milk from the Rotterdam and Groningen Area. Chemosphere 29:2267-2277.
    280.UNECE. 1998 Protocol of Persistent Organic Pollutants under the 1979 Convention on Long-Range Transboundary Air Pollution, UNECE (ECE/EB.Air/60).
    281.United States Court of Appeal. 1980 Environmental defense fund, Inc., petitioner, v.environmental protection agency, respondent, adHoc committee on liquid dielectrics of the electronic industries association et al., Joy manufacturing company, edison electric institute et al., and Aluminum company of America, intervenors, Nos 79-1580, 79-1811 and 79-1816, United States Court of Appeals, Districtof Columbia Circuit, argued 6 June 1980, decided 30 October 1980, http://www.manhattan.edu/wcb/schools/ENGINEERING/envl/wmatysti/2/files/edfcase.htm.
    282.US EPA (United States Environmental Protection Agency). 1984 Guidelines establishing test procedures for the analysis of pollutants under the clean water act. Appendix B: definition and procedures for the determination of method detection limit, reversion 1.11. Federal Register 40 CFR Part 136, vol. 49. U. S. Environmental Protection Agency, Washington, 198-199.
    283.US EPA (United States Environmental Protection Agency). 1986 Guidelines for the health risk assessment of chemical mixtures. Federal Register 51(185): 34014-34025.
    284.US EPA (United States Environmental Protection Agency). 1987 Quality Assurance/Quality Control (QA/QC) for 301(h) Monitoring Programs: Guidance on Field and Laboratory Methods.
    285.US EPA (United States Environmental Protection Agency). 1992 Guidelines for Exposure Assessment Published on May 29. Federal Register 57(104):22888- 22938, EPA/600/Z-92/001.
    286.US EPA (United States Environmental Protection Agency). 1996 Determinative chromatographic separations. Method 8000B..
    287.US EPA (United States Environmental Protection Agency). 1996 PCBs: Cancer dose-response assessment and application to environmental mixtures. National Center for Environmental Assessment Office of Research and Development EPA/600/P-96/001F, September.
    288.US EPA (United States Environmental Protection Agency). 1996 Proposed guidelines for carcinogen risk assessment. Federal Register 61(79):17960- 18011.
    289.US EPA (United States Environmental Protection Agency). 1996 Method 3630C–Silica Gel Cleanup, SW-846 Manual (Test Methods for Evaluating Solid Waste, Physical/Chemical Methods, third edition). (http://www.epa.gov/ epaoswer/hazwaste/test/3_series.htm)
    290.US EPA (United States Environmental Protection Agency). 1996 Method 3620B-Florisil Cleanup, SW-846 Manual (Test Methods for Evaluating Solid Waste, Physical/Chemical Methods, third edition). (http://www.epa.gov/ epaoswer/hazwaste/test/3_series.htm)
    291.US EPA (United States Environmental Protection Agency). 1999 Guidance for Conducting Health Risk Assessment of Chemical Mixtures. NCEA-C-0148. Risk Assessment Forum Technical Panel, Office of Research and Development, Office of Pesticide Programs, Office of Pollution Prevention and Toxics, and Office ofWater, Washington, DC. April.
    292.US EPA (United States Environmental Protection Agency). 2000 Integrated Risk Information System (IRIS) Online. National Center for Environmental Assessment, Washington, DC. (http://www.epa.gov/iris)
    293.US EPA (United States Environmental Protection Agency). 2002 A Guidance mannual to support the assassment of comtanimated sediments in freshwater ecosystem. EPA-905-B02-001-C.
    294.US EPA (United States Environmental Protection Agency). 2003 Exposure and Human Health Reassessment of 2,3,7,8-Tetrachloro dibenzo-p-Dioxin (TCDD) and Related Compounds, Exposure Assessment and Risk Characterization Group National Center for Environmental Assessment - Washington Office Office of Research and Development, Washington, DC. (http://www.epa.gov/ncea/dioxin)
    295.US EPA (United States Environmental Protection Agency). 2005 Region III Risk-Based Concentration (RBC) Table. Jennifer Hubbard, Toxicologist Technical Support Section (3HS41). (http://www.epa.gov/reg3hwmd/risk/human /index.htm)
    296.US EPA(United States Environmental Protection Agency). 1986 Quality criteria for water. EPA 440/5-86-001.
    297.US EPA(United States Environmental Protection Agency). 1995 Method 8082, Polychlorinated biphenyls (PCBs) by capillary column gas chromatography.
    298.US EPA(United States Environmental Protection Agency). 1999 Method 1668, Revision A: Chlorinated biphenyl congeners in water, soil, sediment, and tissue by HRGC/HRMS. U.S. Environmental Protection Agency, Office of Water. EPA-821-R-00-002.
    299.US EPA(United States Environmental Protection Agency). 1999 National Recommended Water Quality Criteria-Correction, EPA 822-Z-99-001.
    300.US Food & Drug Administration Center for Food Safety & Applied Nutrition. FISH AND FISHERIES PRODUCTS HAZARDS AND CONTROLS GUIDANCE: Third Edition June 2001.
    301.Van de Meet D, Mckone TE, Parkerton T, Matthies M, Scheringer M, Wania F,Purdy R, Bennett DH. 2000 Persistence and transport potential of chemicals in a multimedia environment. In: Klecka G, et al., eds. Evaluation of Persistence and Long Range Transport of Organic Chemicals in the Environment. Society of Environmental Toxicology and Chemistry (SETAC).
    302.Van den Berg et al. 1998 Toxic Equivalency Factors (TEFs) for PCBs, PCDDS, PCDFS for humans and wildlife. Environ Health Perspect 106(12):775-792.
    303.Van der Oost R, Goksaryr A, Celander M, Heida H, Vermeulen NPE. 1996 Biomonitoring of aquatic pollution with feral eel (Anguilla anguilla) II. Biomarkers:pollution-induced biochemical responses. Aquat Toxicol 36:189-222.
    304.van Leeuwen FXR, Younes M. 1998 WHO revises the tolerable daily intake (TDI) for dioxins. Organohalogen Compounds 38:295-298.
    305.Van Oostdam J, Donaldson SG, Feeley M, Arnold D, Ayotte P, Bondy G, Chan L, Dewaily é, Furgal CM, Kuhnlein H, Loring E, Muckle G, Myles E, Receveur O, Tracy B, Gill U, Kalhok S. 2005 Human health implications of environmental contaminants in Arctic Canada: A review. Sci Total Environ 351-352:165-246.
    306.Van Oostdam J, Gilman A, Dewailly é , Usher P, Wheatley B, Kuhnlein H, et al. 1999 human health implications of environmental contaminants in Arctic Canada: a review. Sci Total Environ 230:1-282.
    307.Varo I, Navarro JC, Amat F, Guilhermino L. 2002 Characterisation of cholinesterases and evaluation ofthe inhibitory potential of chlorpyrifos and dichlorvos to Artemia salina and Artemia parthenogenetica. Chemosphere 48:563-569.
    308.Waliszewski SM, Pardio VTS, Chantiri JNP, Infanzbn RMR, Rivera J. 1996 Organochlorine pesticide residues in adipose tissue of Mexicans. Sci Total Environ 181:125-131.
    309.Walker CH, Mackness MI. 1987 A-esterases and their role in regulating the toxicity of organophosphates. Arch Toxicol 60:30-33.
    310.Walker JB, Seddon L, McMullen E, Houseman J, Tofflemire K, Corriveau A, Weber JP, Mills C, Smith S, Van Oostdam J. 1999 Organochlorine levels in maternal and umbilical cord blood plasma in Arctic Canada. Sci Total Environ230:1-82.
    311.Walkowiak J, Wiener J, Fastabend A, Heinzow B, Kramer U, Schmidt E, Steingruber H, Wundram S, Winneke G. 2001 Environmental exposure to polychlorinated biphenyls and quality of the home environment: effects on psychodevelopment in early childhood. Lancet 358 (92-93):1602-1607.
    312.Wang SL, Lin CY, Leon Guo Y, Lin LY, Chou WL, Chang LW. 2004 Infant exposure to polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls (PCDD/Fs, PCBs) correlation between prenatal and postnatal exposure. Chemosphere 54:1459-1473.
    313.Wania F, Mackay D. 1996 Tracking the distribution of persistent organic pollutants. Environ Sci Technol 30:390-396.
    314.Warren DA, Kerger BD, Britt JK, Jamesa RC. 2004 Development of an oral cancer slope factor for Aroclor 1268. Regulatory Toxicology and Pharmacology 40:42-53.
    315.Wassermann D, Wassermann M, Cucos S, et al. 1973 Function of adrenal gland-zona fasciculata in rats receiving polychlorinated biphenyls. Environ Res 6:334-338.
    316.Webb RG, McCall AC. 1973 Quantitative PCB standards for electron capture gas chromatography. J Chromatogr Sci 11:366.
    317.Weisglas-Kuperus N, Sas TCJ, Koopman-Esseboom C, et al. 1995 Immunologic effects of background prenatal and postnatal exposure to dioxins and polychlorinated biphenyls in Dutch infants. Pediatr Res 38(3):404-410.
    318.Wessels D, Barr DB, Mendola P. 2003 Use of biomarkers to indicate exposure of children to organophosphate pesticides: implications for a longitudinal study of children’s environmental health. Environ Health Perspect 111:1939-1946.
    319.WHO. 1993 Polychlorinated biphenyls and terphenyls. Environmental Health Criteria, 140. Geneva, Switzerland: World Health Organization, 48-52:444-479.
    320.WHO. 1999 Dioxins and their effects on human health, Fact Sheet No. 225, World Health Organization, Geneva. (http://www.who.int/inf-fs/en/fact225. html)
    321.Whyatt RM, Barr DB. 2001 Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environ Health Perspect 109:417-420.
    322.Winneke G, Bucholski A, Heinzow B, et al. 1998a. Developmental neurotoxicity of polychlorinated biphenyls (PCBs): cognitive and psychomotor functions in 7-month old children. Toxicol Lett 102-103:423-428.
    323.Wolff MS. 1985 Occupational exposure to polychlorinated biphenyls (PCBs). Environ Health Perspect 60:133-138.
    324.Yamashita N, Kannan K, Imagawa T, Miyazaki A, Giesy JP. 2000 Concentrations and profiles of polychlorinated naphthalene congeners in eighteen technical polychlorinated biphenyl preparations. Environ Sci Technol 34:4236-4241.
    325.Yawetz A, Zilberman B, Woodin B, Stegeman JJ. 1998 Cytochromes P-4501A, P-4503A and P-4502B in liver and heart of Mugil capito treated with CYP1A inducers. Environmental Toxicology and Pharmacology 6:13-25.
    326.毕新慧,储少岗,徐晓白. 2001 多氯联苯在水稻田中的迁移行为. 环境科学学报 21(4):454-458.
    327.毕新慧,储少岗,徐晓白. 2001 多氯联苯在土壤中的吸附行为. 中国环境科学 21(3):284-288.
    328.曹文宣,王剑伟.稀有鮈鲫一种新的鱼类实验动物第四届生物多样性保护与利用高新科学技术国际研讨会.
    329.曹玉春,严建华,李晓东,陈彤,岑可法. 2005 垃圾焚烧炉中二噁英生成机理的研究进展. 热力发电(9):15-20.
    330.陈满荣,俞立中,许世远,封克,韩晓非. 2003 长江口潮滩沉积物中PCBs及其空间分布. 海洋环境科学 22(2):20-23.
    331.储少岗,徐晓白,童逸平. 1995 多氯联苯在典型污染地区环境中的分布及其环境行为. 环境科学学报 15(4):423-432.
    332.储少岗,杨春,徐晓白,刘晓星. 1995 典型污染地区底泥和土壤中残留多氯联苯的情况调查。中国环境科学 15(3):199-203.
    333.方展强,张凤君,郑文彪,马广智. 2004 多氯联苯对剑尾鱼超氧化物岐化酶活性的影响. 中国实验动物学报 12(2):96-99.
    334.国家地表水水质标准 (GB-3838-2002). 国家环保局 2002《地表水环境质量标准》(GB3838-2002).
    335.霍传林,王菊英,韩庚辰,关道明. 2002鱼体内EROD活性对多氯联苯类的指示作用. 海洋环境科学 21(1):5-9
    336.贾可欣,麦碧娴,盛国英,傅家谟,彭平安. 2003 珠江广州河段不同粒径沉积物中多氯联苯(PCBs)的分布特征. 地球化学 32(6):606-612.
    337.康跃惠,麦碧娴,盛国英,傅家谟. 2000 珠江三角洲河口及其临近海区含氯有机污染物的分布特征.中国环境科学 20(3):245-249.
    338.黎雯,徐盈,吴文忠,Schramm KW,Kettrup A. 2000鱼肝EROD酶活力诱导作为二噁英的水生态毒理学指标. 水生生物学报 24(3):201-207.
    339.黎雯. 1998 环境样品中二噁英毒性效应的生物标志物研究. 中国科学院水生生物研究所硕士论文.
    340.黎雯. 2003 典型内分泌干扰物的生物筛选方法研究.中国科学院水生生物研究所博士论文.
    341.李春雷,麦碧娴,郝永梅,盛国英,傅家谟. 2004 珠江三角洲空气中多氯联苯污染的区域背景研究. 中国环境科学 24(4):501-504.
    342.李春雷,麦碧娴,郝永梅,王新明,盛国英,傅家谟. 2004 深圳市空气中多氯联苯污染的初步研究. 环境科学研究 17(5):7-9
    343.刘季昂,王文华,王子健. 1998 第二松花江水体沉积物中难降解污染物的种类和含量.中国环境科学,18(6):518-520.
    344.绿色和平组织. 2005 电子废弃物回收在中国和印度:工作场所和环境污染.
    345.绿网. 2003 http://www.green-web.org/infocenter.
    346.马梅,王子健,Anders SD. 2001 官厅水库和永定河沉积物中多氯朕苯和有机氯农药的污染.环境化学 20(3):238-243.
    347.孟庆昱,毕新慧,储少岗,徐晓白. 2000 污染区大气中多氯联苯的表征与分布研究初探. 环境化学 19(6):501-506.
    348.聂湘平,蓝崇钰,栾天罡,黄铭洪,麦志勤. 2001 珠江广州段水体、沉积物及底栖生物中的多氯联苯. 中国环境科学 21(5):417-421.
    349.聂湘平,张凤君,蓝崇钰. 2004 多氯联苯(PCB1254)对斑马鱼(Brachydanio rerio)毒性及其组织结构的影响. 生态科学 23(2):106-109
    350.全球机械网. 2004 http://www.qqma.com/hyzx_detail.asp.
    351.人民网 2006 http://zj.people.com.cn/GB/channel10/36/200601/05/6663.html.
    352.任朝辉. 2004 多氯联苯的测定方法研究及应用. 四川
    353.邵春岩. 2001 中国多氯联苯(PCBs)管理现状及污染防治对策. 持久性有机污染物(POPs)控制研讨会论文集. 北京
    354.宋云横,姜荻,丁超,李国刚. 2005多氯联苯封存点土壤污染情况的调查监测. 中国环境监测 21(4):88-89.
    355.王子健,王毅,马梅. 2001 淮河信阳和淮南段沉积物中PCBs的生态风险评估. 中国环境科学 21(3):262-265.
    356.习志群 储少岗 徐晓白 张甬元 徐盈. 1998 东湖水体中多氯联苯的研究.海洋与湖沼 29(4):436-440.
    357.新华网. 2005 http://news.xinhuanet.com/focus/2005-04/24/content_ 2864341. htm.
    358.新华网. 2004 http:// www.cern.gov.cn/files/h/xinhua22.htm.
    359.新华网. 2005 http://news.xinhuanet.com/ fortune/2005-02/07/ content_2557578. htm
    360.徐盈,吴文忠,张甬元. 1996 利用EROD生物测试法快速筛选二恶英类化合物.中国环境科学 16(4):279-284.
    361.杨永亮,潘静,李悦,石磊,殷效彩,李凤业,Kevin Jones. 2003 青岛近海沉积物PCBs的水平与垂直分布及贝类污染. 中国环境科学 23(5):515-520.
    362.袁东星,杨东宁,陈猛,许鹏翔,钱耀荣,王建林. 2001 厦门西港及闽江口表层沉积物中多环芳烃和有机氯污染物的含量及分布.环境科学学报 21(1):107-112.
    363.张庆华. 2004 太湖和海河流域天津段二恶英类化合物污染特征的研究. 北京
    364.中国家电在线. 2004 http://www.eaonline.com.cn/info.
    365.中国科技信息网. 2001 http://www.chinainfo.gov.cn/data/ 200112/1_20011211 _ 24514.html.
    366.中国循环经济网. 2005 http://www.chinace.org.cn/Content.
    367.周春宏,柏仇勇,胡冠九,张爱茜. 2005 江苏省典型饮用水源地多氯联苯污染特性调查. 化工时刊 19(3):22-25.
    368.朱经发,林辉东,王德汉,彭俊杰. 2002 电子废物现状评述与资源化初探.土壤与环境 11(3):307-310.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700