几种生理调节剂对动物生长及有关神经内分泌的影响
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摘要
本研究探讨了阶段性相继饲喂三种生理调节剂对单胃动物生长性能和复
胃动物瘤胃代谢的影响及其作用机制，同时探讨了大豆黄酮对去势仔猪生长
的影响及其作用机制。实验分两大部分。
一、阶段性相继饲喂三种生理调节剂对单胃动物生长性能和复胃动
物瘤胃代谢及有关内分泌激素的影响
实验系列一 生长期大鼠20只，第一阶段日粮内添加2mg/kg F89，饲喂
42天。第二阶段添喂剂量为14.2mg/kg·BW·d半胱胺CS87，每日饲喂，持续
25天；第三阶段添喂4mg/kg的Cimaterol（CIM），饲喂25天。与对照组相比，
第一阶段试验组大鼠日均摄食量、日增重和饲料转化率分别提高13.93％
（P＜0.01），20.25％（P＜0.05）和5.31％；第二阶段三者分别提高10.81％
（P＜0.05）、13.00％和1.97％；第三阶段三者分别提高4.11％，-56.86％（P＜0.05）
和-141.36％。相继饲喂结束时试验组大鼠腓肠肌净重和其与体重之比分别提
高33.33％（P＜0.05）和26.67％（P＜0.05）。血清中生长激素（GH），胰岛素样生
长因子—1（IGF-I）和游离脂肪酸（FFA）分别比对照组提高7.98％（P＜0.01），
27.77％（P＜0.01）和41.06％（P＜0.05），脲素氮（SUN）含量下降19.48％（P＜0.01）。
上述实验结果表明：动物生长期及生长肥育期相继添喂三种生理调节剂可以
明显影响动物的IGF-I、GH水平和代谢活动，从而促进动物生长，提高肌肉
比率。
实验系列二 选取五只装有永久性瘤胃瘘管的去势公山羊，以青干花生秧
+精料为基础日粮。实验采取前后自身对照的方法。第一阶段为对照期，饲养
一周后采取血样和瘤胃液样；第二阶段精料内添加15mg/kg·BW·d的CS87，
喂服10天；第三阶段精料内添加8mg/kg的F89喂服5天。第四阶段精料内
添加0.1mg/kgBW的CIM，喂服5天。与第一阶段相比，第二阶段瘤胃液中
郭留君几种生理调节剂对动物生长及有关神经内分泌的影响
总挥发性脂肪酸（TVFA人 乙酸l丙酸（AN人 NH3村和 Q－氨基氮（AAN）
分别提高17．47％0刃刀5），4．09％，13．98％（P＜0．05）和！．28％，第三阶段
四者分别提高．12．82％（P—0．07），7．73％，5．38％和．32．69％（P＜0．05）；第四阶
段四者分别提高3．33％，o．45％，－9．68％和8．33％：潘胃微生物蛋白（MCP）
在整个过程中没有显著变化。血液中NH。N在第二阶段，第三阶段，第四阶
段分别升高．19．70％（＊刃刀5），67人＊％（P＜o刀1），9．巴5％；AAN分别提高
0．40％，37．65％（P＜0刀1），8．37％；SUN分别下降3．44％，6乃5％，15．48％·
o＝0．00。实验结果表明阶段性相继饲喂在一定程度上提高瘤胃发酵和氮代
谢，促进体内对氮的吸收和利用，抑制蛋白降解代谢。’
实验系列三四只装有永久性瘤胃瘦管的山羊，采用自身对照的方法，第
一阶段为 1期，即对照期，饲喂青干草；第二阶段为＊期，添加 0．3mg！kg·BWd
的Clenbuterol（CL），第三阶段为互 期，添力0二m叭g”BW、d CL十sing／kg F89，
第四阶段为 IV期，添加 0．3mg／kg”BWd的 CL＋sing／kg的 F89＋15mghe”BWd
CS87，以上均饲喂7天。与对照期相比，CL期瘤胃液D汗A，NH3－N，AAN
和＊＊P分别升高－19．55％（P＜0乃5），15．51％（P＜0刀5），14．40WP功＊匀 和
－12．08％，A／P比例显著下降。CL＋F89期四者分别升高 23．00o（P＜0．of），
43．94％（＜0刀1），120．16o／o（P＜刀1）和－I6．ZI％。Ap下降不明显。CL＋F89＋CS87
期四者分另升高9．95％，55．74％（卜0刀1），181人8W卜0刀1）和25．66WP＜0刀5），
A／P 比例明显下降。血液中NH3－N 在后三个阶段依次升高
19二3仰P＜o．05），23．巴5W＊刃＊1）和3且．54WP＜o＊5）；AAN在后三个阶段依次
升高－11．29％，！3．54％（P＜o．05）和5．87％；血液中＊UN的含量依次升高9．68％，
32·26％（P＜o．05）和4O刀0仰＊仍．of）；血液中生长激素（oH）在实验处理阶段
变化不显著。本实验表明：CL使发酵类型由乙酸型转化为丙酸、丁酸型发酵，
氮代谢增强；CL＋F89能使瘤胃酵解有所提高，丙酸型发酵和氮代谢进一步
增强；CL＋F89＋CS87能加强对能量和氮的利用，使瘤胃纤维素降解和微生
物蛋白质合成均有显著性提高，氮代谢和荫留在后三阶段依次提高；三种生
理调节剂之间在一定程度上存在协同效应。
2
摘 要
二、大豆黄团对雄性大鼠和去势仔猪生长及有关内分泌的影响
实验系列四：24只断乳雄性大鼠随机分为实验组和对照组，实验组饲喂
添加 3mg八g大豆黄酮的日粮，饲喂 30大。与对照组相比，实验组大鼠日增
重，采食量，料重比分别提高 14．90％（P（．of），18．31％（P＜0．05）和 1．61％；
胭体重，腰胁部脂肪重，胖肠肌重，骨骼净重分别提高
16．6％（P＜0．05），11．5％，8．8％和14．5％（P＜0．05）；其?
F89,CS87 and ~ -agonist supplemented consecutively were used to study the
effects of them on the growth performance of non-ruminant animals and the rumen
metabolism of ruminant animals, meanwhile,daidzein was used to study the effects
on growth of male rats and castrated piglets.The research includes two parts.
Part I Effect of three physiological regulators supplemented
consecutively on the growth performance of non-ruminant animals
and the rumen metabolism of ruminant animals.
Series 1
Growing rats were fed diet supplemented with 2 mg/kg F89 for 42 days, then with
14.2 mg/kg BWd CS87 for 25 days, finally with 4 mg/kg Cimaterol for 25 days.
Compared with control group, F89 increased feed intake 13 .93%(p<0.0 1) per day
BW gain 20.25% and decreased feed/gain 5.3 1%;CS87 increased significantly feed
intake 10.81% and BW gain 13.00% and decreased feed/gain 1.97%; CIM increased
feed intake 4.11% and decreased BW gain 56.86%(P -141 .36%.At the end of this experiment, the weight of gastrocnemius (right side)
and its relative percentage to the body weight were increased by 33.33%(P<0.05)
and 26.67% (P<0.05), respectively.The concentrations of GH. IGF-I and FFA in
serum were increased by 7.98%(p<0.O1 ),27.77%(p respectively; whereas that of SUN decreased by 19.48%(p<0.01).These results
55
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demonstrate that growing rats fed F89,CS87 and Cimaterol consecutively may
enhance the levels of GH .~ IGF-l in serum and affect the activity of metabolism
significantly, furthermore increase the growth of rats and the validity of lean meat.
Series 2
Five castrated male goats with permanent rumen fistulae were used to study the
effect of Cs (15 mg/kg. BW.d) supplemented for 10 days,F89(2 mg/kg) for Sdays
and Cimaterol (8 mg/kg) for 5 days consecutively on rumen metabolism. Compared
with those of control stage, at the end of CS87 experimental stage, the A/P ratio, the
concentration of TVFA, NH3-N and AAN of the rumen liquid increased by 4.09%,
l7.47%(p experimental stage, those increased by 7.73%, ?2.82%(p<0.05), 5.38% and
?2.69%; At the end of Cimaterol experimental stage, those increased by
respectively 0.45%, 3.33%, -9.68% and 8.33%: the concentration of MCP of the
rumen liquid in respective CS87, F89 and Cimaterol stages have no significant
change, but the concentration of NH3-N of the blood increased by respectively
-19.70% (p<0.0S), 67.42%(p<0.Ol) and -9.85%; Those of AAN increased by
0.4%,37.65%(P<0.01) and 8.37% , respectively. Those of SuN decreased by 3.44%,
6.05% and 1 S.48%(p=O.09), respectively. The results indicate that CS87, F89 and
Cimaterol supplemented consecutively improve rumen fermentation and nitrogen
metabolism to a certain extent; meanwhile enhance absorbability and validity of
nitrogen in vivo.
Series 3
Four castrated male goats with permanent rumen fistulae were used to study the
effect of Clenbuterol (0.3mg/kgBWd) supplemented for 10 days, Clenbuterol (0.3
mg/kgBWd) +F89 (8 mg/kg) for 10 days, Clenbuterol (0.3 mg/kgBWd)+F89 (8
mg/kg)+Cs87 (15 mg/kgBWd) for 10 days consecutively on the rumen
fermentation and metabolism. Compared with those of control stage, the
concentration of TVFA, NH3-N, AAN and MCP, at the end of CL stage, increased
by respectively -
胃动物瘤胃代谢的影响及其作用机制，同时探讨了大豆黄酮对去势仔猪生长
的影响及其作用机制。实验分两大部分。
一、阶段性相继饲喂三种生理调节剂对单胃动物生长性能和复胃动
物瘤胃代谢及有关内分泌激素的影响
实验系列一 生长期大鼠20只，第一阶段日粮内添加2mg/kg F89，饲喂
42天。第二阶段添喂剂量为14.2mg/kg·BW·d半胱胺CS87，每日饲喂，持续
25天；第三阶段添喂4mg/kg的Cimaterol（CIM），饲喂25天。与对照组相比，
第一阶段试验组大鼠日均摄食量、日增重和饲料转化率分别提高13.93％
（P＜0.01），20.25％（P＜0.05）和5.31％；第二阶段三者分别提高10.81％
（P＜0.05）、13.00％和1.97％；第三阶段三者分别提高4.11％，-56.86％（P＜0.05）
和-141.36％。相继饲喂结束时试验组大鼠腓肠肌净重和其与体重之比分别提
高33.33％（P＜0.05）和26.67％（P＜0.05）。血清中生长激素（GH），胰岛素样生
长因子—1（IGF-I）和游离脂肪酸（FFA）分别比对照组提高7.98％（P＜0.01），
27.77％（P＜0.01）和41.06％（P＜0.05），脲素氮（SUN）含量下降19.48％（P＜0.01）。
上述实验结果表明：动物生长期及生长肥育期相继添喂三种生理调节剂可以
明显影响动物的IGF-I、GH水平和代谢活动，从而促进动物生长，提高肌肉
比率。
实验系列二 选取五只装有永久性瘤胃瘘管的去势公山羊，以青干花生秧
+精料为基础日粮。实验采取前后自身对照的方法。第一阶段为对照期，饲养
一周后采取血样和瘤胃液样；第二阶段精料内添加15mg/kg·BW·d的CS87，
喂服10天；第三阶段精料内添加8mg/kg的F89喂服5天。第四阶段精料内
添加0.1mg/kgBW的CIM，喂服5天。与第一阶段相比，第二阶段瘤胃液中
郭留君几种生理调节剂对动物生长及有关神经内分泌的影响
总挥发性脂肪酸（TVFA人 乙酸l丙酸（AN人 NH3村和 Q－氨基氮（AAN）
分别提高17．47％0刃刀5），4．09％，13．98％（P＜0．05）和！．28％，第三阶段
四者分别提高．12．82％（P—0．07），7．73％，5．38％和．32．69％（P＜0．05）；第四阶
段四者分别提高3．33％，o．45％，－9．68％和8．33％：潘胃微生物蛋白（MCP）
在整个过程中没有显著变化。血液中NH。N在第二阶段，第三阶段，第四阶
段分别升高．19．70％（＊刃刀5），67人＊％（P＜o刀1），9．巴5％；AAN分别提高
0．40％，37．65％（P＜0刀1），8．37％；SUN分别下降3．44％，6乃5％，15．48％·
o＝0．00。实验结果表明阶段性相继饲喂在一定程度上提高瘤胃发酵和氮代
谢，促进体内对氮的吸收和利用，抑制蛋白降解代谢。’
实验系列三四只装有永久性瘤胃瘦管的山羊，采用自身对照的方法，第
一阶段为 1期，即对照期，饲喂青干草；第二阶段为＊期，添加 0．3mg！kg·BWd
的Clenbuterol（CL），第三阶段为互 期，添力0二m叭g”BW、d CL十sing／kg F89，
第四阶段为 IV期，添加 0．3mg／kg”BWd的 CL＋sing／kg的 F89＋15mghe”BWd
CS87，以上均饲喂7天。与对照期相比，CL期瘤胃液D汗A，NH3－N，AAN
和＊＊P分别升高－19．55％（P＜0乃5），15．51％（P＜0刀5），14．40WP功＊匀 和
－12．08％，A／P比例显著下降。CL＋F89期四者分别升高 23．00o（P＜0．of），
43．94％（＜0刀1），120．16o／o（P＜刀1）和－I6．ZI％。Ap下降不明显。CL＋F89＋CS87
期四者分另升高9．95％，55．74％（卜0刀1），181人8W卜0刀1）和25．66WP＜0刀5），
A／P 比例明显下降。血液中NH3－N 在后三个阶段依次升高
19二3仰P＜o．05），23．巴5W＊刃＊1）和3且．54WP＜o＊5）；AAN在后三个阶段依次
升高－11．29％，！3．54％（P＜o．05）和5．87％；血液中＊UN的含量依次升高9．68％，
32·26％（P＜o．05）和4O刀0仰＊仍．of）；血液中生长激素（oH）在实验处理阶段
变化不显著。本实验表明：CL使发酵类型由乙酸型转化为丙酸、丁酸型发酵，
氮代谢增强；CL＋F89能使瘤胃酵解有所提高，丙酸型发酵和氮代谢进一步
增强；CL＋F89＋CS87能加强对能量和氮的利用，使瘤胃纤维素降解和微生
物蛋白质合成均有显著性提高，氮代谢和荫留在后三阶段依次提高；三种生
理调节剂之间在一定程度上存在协同效应。
2
摘 要
二、大豆黄团对雄性大鼠和去势仔猪生长及有关内分泌的影响
实验系列四：24只断乳雄性大鼠随机分为实验组和对照组，实验组饲喂
添加 3mg八g大豆黄酮的日粮，饲喂 30大。与对照组相比，实验组大鼠日增
重，采食量，料重比分别提高 14．90％（P（．of），18．31％（P＜0．05）和 1．61％；
胭体重，腰胁部脂肪重，胖肠肌重，骨骼净重分别提高
16．6％（P＜0．05），11．5％，8．8％和14．5％（P＜0．05）；其?
F89,CS87 and ~ -agonist supplemented consecutively were used to study the
effects of them on the growth performance of non-ruminant animals and the rumen
metabolism of ruminant animals, meanwhile,daidzein was used to study the effects
on growth of male rats and castrated piglets.The research includes two parts.
Part I Effect of three physiological regulators supplemented
consecutively on the growth performance of non-ruminant animals
and the rumen metabolism of ruminant animals.
Series 1
Growing rats were fed diet supplemented with 2 mg/kg F89 for 42 days, then with
14.2 mg/kg BWd CS87 for 25 days, finally with 4 mg/kg Cimaterol for 25 days.
Compared with control group, F89 increased feed intake 13 .93%(p<0.0 1) per day
BW gain 20.25% and decreased feed/gain 5.3 1%;CS87 increased significantly feed
intake 10.81% and BW gain 13.00% and decreased feed/gain 1.97%; CIM increased
feed intake 4.11% and decreased BW gain 56.86%(P
and its relative percentage to the body weight were increased by 33.33%(P<0.05)
and 26.67% (P<0.05), respectively.The concentrations of GH. IGF-I and FFA in
serum were increased by 7.98%(p<0.O1 ),27.77%(p
55
$~
demonstrate that growing rats fed F89,CS87 and Cimaterol consecutively may
enhance the levels of GH .~ IGF-l in serum and affect the activity of metabolism
significantly, furthermore increase the growth of rats and the validity of lean meat.
Series 2
Five castrated male goats with permanent rumen fistulae were used to study the
effect of Cs (15 mg/kg. BW.d) supplemented for 10 days,F89(2 mg/kg) for Sdays
and Cimaterol (8 mg/kg) for 5 days consecutively on rumen metabolism. Compared
with those of control stage, at the end of CS87 experimental stage, the A/P ratio, the
concentration of TVFA, NH3-N and AAN of the rumen liquid increased by 4.09%,
l7.47%(p
?2.69%; At the end of Cimaterol experimental stage, those increased by
respectively 0.45%, 3.33%, -9.68% and 8.33%: the concentration of MCP of the
rumen liquid in respective CS87, F89 and Cimaterol stages have no significant
change, but the concentration of NH3-N of the blood increased by respectively
-19.70% (p<0.0S), 67.42%(p<0.Ol) and -9.85%; Those of AAN increased by
0.4%,37.65%(P<0.01) and 8.37% , respectively. Those of SuN decreased by 3.44%,
6.05% and 1 S.48%(p=O.09), respectively. The results indicate that CS87, F89 and
Cimaterol supplemented consecutively improve rumen fermentation and nitrogen
metabolism to a certain extent; meanwhile enhance absorbability and validity of
nitrogen in vivo.
Series 3
Four castrated male goats with permanent rumen fistulae were used to study the
effect of Clenbuterol (0.3mg/kgBWd) supplemented for 10 days, Clenbuterol (0.3
mg/kgBWd) +F89 (8 mg/kg) for 10 days, Clenbuterol (0.3 mg/kgBWd)+F89 (8
mg/kg)+Cs87 (15 mg/kgBWd) for 10 days consecutively on the rumen
fermentation and metabolism. Compared with those of control stage, the
concentration of TVFA, NH3-N, AAN and MCP, at the end of CL stage, increased
by respectively -
引文
1. Hammand, Jr.J.et al. 1983, General principle-metabolites and growth .In:Hammand's farm animals. Edward Arnold, pp.21-24
2．周光宏 主编，1999，，肉品学。中国农业科技出版社，P52-54
3. Harvey, A.L. and Marshall. I. G. 1984, Muscle. In: Physiology and biochemistry of domestic fowl. Vol. 4, B.M.Freeman(ed), Academic Press.pp 219-222
4. Moss, F.P. 1986, The relationship between the dimensions of the fibers and the number of nuclri during growth of skeletal muscle in the fowl.Am.J.Anat. 122:555-561
5. Beermann, D.H. Effects of maternal dietary restriction during gestation and lactation, muscle sex and age on various indices of skeletal muscle growth in rats.J.Anim. Sci.57: 328. 1983.
6. Swenson M.J. editor. 1984.Duke'Physiology of Domestic Animals. Tenth Edition. Cornell University Press. pp 548-580
7. Sprncer, G.S.G. 1985,Hormonal systems regulating growth-a review. Anim. Sci.12:31-46
8．宋淑兰，1990，下丘脑促垂体激素和因子。神经内分泌学(谢启文主编)，辽宁科技出版社，pp．41-58
9. Brood, C.G.D. Hindmarsh P.C. and Stanhope R. 1988.Growth and growth hormone secretion (Review).J Edocrinol, 119(2): 179-184
10. Onneau, M. 1991. Regulation of pig growth by somatotropic hormone: I secretion and mode of action. Pig News and Information 12(1): 29-37
11. Etherton TD. 1989.The mechanisms by which porcine growth hormone improves pig growth performance.biotechnology in growth regulation. Heap RB and Prosser (Eds). C.G. Butterworths, London. 97-105
12. Brandsrna H A, Henken A.M et al. 1991. Effects of recombinant porcine somatotropin on metabolic rate in growing pigs. J Anim Sci, 69:2961—2970
13. Dunshea FR, Harris DM et al. 1992. Effect of porcine somatotropin on in vivo
glucose kinetics and lipogenesis in growing pigs. J Anim Sci.70:141-151
14． Magri K.A, Gopinath R and Etherton T.D.1987． Inhibition of lipogenic enzyme activities by porcine growth hormone (pGH) J Anim Sci, 65 (Suppl 1) :258
15． Hu C.Y. Novakofski J.E. and. Mersmann H. J. 1987． Hormonal control of porcine adipose tissue fatty acid release and cyclic cAMP concentration. J Anim Sci, 64: 1031-1037
16． Walton P.E and Etherton T.D. 1986． Stimulation of lipogenesis by insulin in swine adipose tissue: Antagonism by porcine growth hormone.J.Anim Sci. 62: 1584-1595
17． Walton P.E, Etherton T.D and Evock C.M. 1986． Antagonism of insulin action in cultured adipose tissue by pituitary and recombinant porcine growth hormone: potentiation by hydrocortisone. Endocrinology,118: 2577-2581
18． Isaksson OG, Lindahl A et al.1987． Mechanism of the stimulatory effect of growth hormone on the longitudinal bone growth. Endcrine Reviews. 8:426-438
19． Tomas F.M.Campbell R.G et al. 1992． Growth hormone increases whole-body Protein turnover in growing pigs, J Anim Sci. 70:3138-3143
20． Grant. A. L. et al. 1991． Administration of growth hormone to pigs alters the relative amount of insulin-like growth factor-Ⅰ mRNA in liver and sketetal muscle. J.Endocr.130: 331-338．
21． Dauhaday W.H and Rotweh.P. 1989． Insulin-like growth factors Ⅰ and Ⅱ peptide . messenger ribonucleic acid and gene structures. Serum. and tissue concentrations. Endocrine Reviews. 10: 68-91．
22． Owens, P. C et al. 1990 . Development changes in growth hormone, insulin-like growth factors (IGF-Ⅰ and IGF-Ⅱ) and IGF-binding proteins in plasma of young growing pigs, J. Endocr.128: 439-447．
23． Hizuka, N et al. 1986． Insulin-like growth factor I stimulate growth in normal growing rats. European J .of Pharmacol. 125: 143-150．
24． Dodson M.V et al .1985． Ovine somatomedin multiplication-stimulating activity, and insulin promote skeletal muscle satellite cell proliferation in
vitro. Endocr. 117,2357-2363．
25． Zadik .Z. et al. 1985． The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J.clin.Endocrinol. Metab. 60． 513-516．
26． Tannenbaum.G.S. et al.1985． The interreactionship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion Endocr.115:1952-1957．
27． Wehreubery, WB. et al. 1982． Inhibition of the pulsation secretion of growth hormone by monoclonal antibodies to the hypothalarnic growth hormone releasing factor (GRF). Endocr. 111: 2147-2148．
28． Vale, W. et al.1983． Effects of synthetic human pancreatic tumor GH releasing factor and somatotatin, triiodothronine and dexamethasone on GH secretion in vitro Endocr. 112: 1553-1555．
29． Edens. 1979． Age and sex-related differences in episodic growth hormone secretion in the rat.Endocr.105: 555-560．
30． Clark, R.G. et al .1989． Intravenous growth hormone response to patterned infusions in hypophysectomized rats J.Endocr. 104: 53-61
31． Oppenheimer J.H and Surks M.I. 975． Biochemical basis of thyroid hormone action. Biochemical actions of hormone (Vol Ⅲ).Litwack G (Ed). academic press , New York, 119-159．
32． Brent G.A, Moore D.D and Larsen P.R.1991． Thyroid hormone regulation of gene expression (Review). Annu Rev Physiol, 53:17-35．
33． Valcari R, Zini M and Portioli I.1992． Thyroid hormone and growth hormone secretion (Review). J Endocrinol Invest, 15(4) : 313-330．
34． Gray, D.G. et al. 1986, Implanting young bulls with zeranol from birth to four slaught ages Ⅲ growth performance and endocrine aspects. J.Anim.Sci.63: 747
35． Perston, R.L. 1975, Biological responses to estrogen abbitives in maet produing cattle and lamds. J.Anim.Sci.44: 1414
36． Johson, B.H. et al .1982, Suppression of luteinzing hormone and testosterone
secretion in bulls following ACTH treatment. Biol. Reprod.26:305-312
37. Thomas, K.M.andRodway. R.G. 1983, Adrenal function in lambs implanted with trenbolone acetate plus oestradiol or with trenbolone acetate alone.Anim.prod.36:529
38. Henricks, D.M. et al. 1984,Sex difference in plasma in cortisol and growth in the bovine.Janim. Sci.59:376
39. Breier,B.H. et al.1988, The somatotrophic axis in young steers:influence of nutritional status and oestradiol-17 βon hepatic high-and low-affinity somatotrophi? binding sites. J.Endocrin. 116:169
40. 韩正康，陈杰主编．1988．反刍动物瘤胃的消化和代谢．科学出版社．pp64-79
41. Hino, T. And Russell. J.B. 1987. Relation contributions of ruminal bacteria and protozoa to the degradation of protein in vitro. J.Anim. Sci. 64:261—270.
42. Wallace, R.J. and Brammall. M. L. 1985. The rate of different species of bacteria in the hydrolysis of protein in the rumen. J.Gen. Microbiol. 131:821.
43. Maxshall and Stern, D.et al. 1979. Methods for determining and factors affecting rumen microbial protein synthesis: a review. J.Anim. Sci. 49:1590—1603.
44. Broderick, G.A. and Wallace. R.J. 1988. Effects of dietary nitrogen source on concentrations of ammonia, free amino acids and fluorescamine reactive peptides in the sheep rumen. J.Anim. Sci. 66: 2233—2238.
45．杨国宇．1994．睾酮调控瘤胃消化代谢的研究．南京农业大学博士论文。
46．蔡天权，韩正康，陈伟华，陈杰。1990。17β-雌二醇对瘤胃消化代谢调节的研究。南京农业大学学报。13(4 增)：131-136。
47．王金洛，韩正康，陈杰。1990。孕酮调节消化代谢的研究。南京农业大学学报。14(2)：74-78。
48. Fox,M.T.etal.1989.Effect of omeprazole treatment on food intake and blood gastrin and pepsinogen levels in the calf.Res.Vet.Sci.46:280-288
49．余雄。1994。反刍动物瘤胃和十二指肠内容物肽类和胃泌素含量变化的研究。南京农业大学硕士论文。
50．沈赞明，陈杰，陈伟华。1999，五肽胃泌素对瘤胃微生物代谢的影响。动物营养学报。11(增)：269-270
51. Kennedy, P.M.et al. 1997.Studies on relationship between thyroid function, cold acclimation and retention in time of digesta in sheep. J.Anim. Sci.45:1084-1090.
52．华刚，韩正康。1990。甲状腺片或甲基硫脲嘧啶对血液甲状腺激素及瘤胃代谢的影响。南京农业大学学报。13(增)：125-130。
53. Randall L.O. 1960. Pharmacology of methaminodiazepoxide. Dis Nerv Syst. 21:7—15
54. Bail C.A and McLanghlin C.L. 1979. A review of the behavioral and Physiological responses to elfazepam,a chemical feed intake stimulant. J.Anim Sci.49(5):1371—1395
55．姜洪林，韩正康。1993。苯二氮卓类化合物F89对大鼠、肉鸡摄食和增重的影响。南京农业大学学报，16(增刊)：9-14。
56．丁宏标，韩正康等。1997。苯二氮卓化合物F89对猪的生长胴体组成组成和养分代谢的影响。中国农业科学。30(5)：75-80
57. Han Zengkang, Ge shenfang and Lu Tianshui 1992 studies on improving theperformance of chinese Langshan chicken by neuroendocrine control.The sixth animal Science Congress of Asian-Australian association of animal production societies (AAAP), Bangkok,Tailand.
58．葛盛芳等。1999。克伦特罗和苯二氮卓化合物F89对肉鸡生长、胴体组成和血液代谢物的影响。南京农业大学学报。22(1)：73-76
59. Dinus,D.A. and Baile,C.A. 1997, Beef cattle responses to a feed intake stimulate given along and in combination with a propionate enhancer. J.Anim. Sci. 45:147-153
60. Della Fera, M.A., Mclaughlin, C.L. Weston. R.H.1977, Rumen function during elfazepam and 9-aza-cannabinol elicited feeding in sheep. Fed. Proc.36:1141 (Abstr.4600)
61．潘同斌，韩正康。1993，F89对湖羊摄食、消化率及复胃消化代谢的影响。南京农业大学学报。16(增)：35-40
62. Klotz U.1991. Occurrence of "natural" benzodiazepines. Life sci,48:209—215
63．朱国庆。1993．苯二氮卓和γ-氨基丁酸A／苯二氮卓／氯离子通道复合物。生理科学进展。24(2)，145-148
64．颜光美。1990．中枢型苯二氮卓受体研究．生理科学进展，21(3)：258—259
65. Sander DJ. 1985. Minireview. GABA and behavioral effects of anxiolytic drugs Life Sci, 36:1503—1513
66．姜洪林，韩正康．1992，侧脑室注射氟安定对家兔摄食的影响。中国应用生理学杂志。8(1)：77～78
67．赵茹茜，韩正康．1993。F89对鹅摄食和血浆胰岛素、β-内啡肽水平的影响。南京农业大学学报。16(增)：1-4
68. Selye,H. and Szabo. S.1973. An experimental model for the production of perforating duodenal ulcers by cysteamine in the rat. Nature.244: 258.
69. Millard, W.J. Sager, S. M, Badger, T.M and Martin. S. B. 1983. Cysteamine effects on growth hormone secretion in the male rat. Endocrinology. 112:509—517.
70．林玲，韩正康。1991。生长抑素抑制剂-半胱胺促进大鼠、幼兔生长的研究。中国应用生理学杂志。7(4)：345-347
71．韩正康，林玲。1992。生长抑素抑制剂-半胱胺促进肉用仔鸡生长的研究。畜牧兽医学报。23(4)：314-318
72．刘皙洁，韩正康，1997。半胱胺颗粒料促进羔羊增重的实验。黑龙江畜牧兽医。11：9～11
73．刘皙洁，韩正康等。1998。半胱胺对香猪胃液分泌、血液胃泌素和生长抑素水平的影响。畜牧与兽医。30(3)：105-107
74．王艳玲等。1997。半胱胺促进绵羊生长的实验研究。全国动物生理生化第五次学术会议论文摘要汇编。P106
75．丁宏标、陈杰、韩正康。1994，CS87促进猪生长的研究。南京农业大学学报。17(4)：87～91
76．王艳玲、陈伟华、韩正康。1997。不同剂量半胱胺对肉用仔鸡增重及血液生长抑素、生长激素含量的影响。中国畜牧兽医杂志。33(4)：11-13
77．王子荣，陈杰等。1999。半胱胺和生长抑素基因工程苗对反刍动物消化、代谢和生长的影响及作用机理研究。博士研究生毕业论文
78．刘宗柱，韩正康。1996。去势及灌注半胱胺对湖羊消化、代谢的影响。南京农业大学学报。19(2)：54-58
79．刘宗柱，沈延法，韩正康。1996。半胱胺对绵羊消化代谢的影响。畜牧兽医学报。27(3)：212-219
80．韩正康等。1996。半胱胺引起绵羊外周血液β-内啡肽和几种主要代谢激素的变化。畜牧兽医学报。27(3)：193-198
81. William J.M et al.1983.Cysteamine effects on growth hormone secretion in the male rat. Endocrinology, 112:509—517
82. Williams. P.E.V.1987, The use of β-agonists as a maens of altering body composition in livestock species. Nutrition Abtracts and Reviews (Serie B).57:453-464
83. Baker,P.K., Dalrymple, R.H., Ingle,D.L, Ricks,C.A.1984,Use of a β-adrenergic agonist to alter muscle and fat deposition in lamds.J.Anim. Sci.59:1256-1261
84. Ricks, C.A., Baker, P.K., Dalrymple, R.H. 1984. Use of clenbuterol to alter muscle and fat accretation in swine. Fed. Proc.43:857
85. Dalrymple, R.H. baker, P.K., Ginger, P.E. 1984. A repartitioning agent to improve performance and carcass composition of broilers. Poultry Sci .63:2376-2383
86. Maltin, C.A., Delday, M.I., Reeds, P.J. 1986,The effect of a growth promoting drug clenbuterol on fibre frequency and area in hind limd muscles from young male rats. Bioscience Reports.6:293
87. Williams, P.E.V., Pagliani, L. Innes,G.M. 1987, Effects of a β-agonist(clenbuterol) on growth, carcass composition, protein and energy metabolism of veal calves. British Journal of Nutrition,57:417-428
88. Emery,P.W., Rothwell, N.J., Stock, M.J. Winter, P.D. 1984 Chornic effects of β-adrenergic agonists on body composition and protein synthesis in the rat.Bioscienee Reports,4:83-92
89. Beermann, D.H. Butler, W.E. Hogue. D. E. 1987, Cimaterol-induced muscle hypertrophy and alterd endocrine status in lambs.J.Anim.Sci.65:1514-1524
90．姜卫红，韩正康，陈杰，1990，β-肾上腺素能激动剂克伦特罗对瘤胃微生物蛋白质分解作用的影响。全国动物生理生化第二次学术会议论文摘要汇编。1990年10月于山东烟台。
91. Terry, L.C. and Craig. R. 1985. Cysteamine effects on menoamines, dopamine β-hydroxylase and hypothalamic-pituitary axis (Abstr). Neuroendocrinology.41(6): 467
92．朱祖康，韩正康。1992。β-肾上腺素能激动剂克伦特罗对湖羊消化代谢的影响。全国动物生理生化第三次学术会议论文摘要汇编。1992年10月于四川成都。
93. Mersmann Harry J. 1998. Overview of the effects of β-Adrenergic receptor agonists on animal growth including mechanisms of action. J.Animal Sci,76:160—172
94. Squires E.J,Adeolao,et al.1993.The role of growth hormones,β-Adrenergic agents and intact males in pork production: A review. Can. J. Animal Sci,73(1): 1—23
95．王国杰，韩正康，陈伟华。1995。大豆黄酮对大鼠肌肉生长和几种内源激素水平的影响。动物学研究。16(1)：23-29
96．王国杰等。1994。大豆黄酮对肉鸡生长的影响及其作用机制的研究。广东畜牧兽医科技。19(3)：3-4
97．赵志辉，陆天水。1997。大豆黄酮对猪生长的影响及其神经内分泌机理研究。硕士研究生毕业论文
98．王国杰，韩正康。1993。克伦特罗和异黄酮植物雌激素对骨骼肌细胞生长的影响。南京农业大学学报。16(增刊)：15～18
99．王国杰。1992。异黄酮植物雌激素对肌肉生长的影响及作用机制的研究。博士研究生毕业论文
100．谢启文主编 1990。神经内分泌学 辽宁科学技术出版社 53：185
101. Arimandi, B.H. Getlinger, M.J. Goyal, N.V. Birbaum. I.R. 1996. A soy proteincontaining diet prevents bone loss due to ovarian hormone deficiency. Second international symposium on the role of soy in preventing and treating chronic disease.Brussels-Belgium.pp19
102．张荣庆，韩正康。异黄酮植物激素IFD对胎儿生长的影响。生理通讯，1993，12(增)：153
103．刘根桃，陈伟华，陈杰等。妊娠后期母猪饲喂大豆黄酮对哺乳仔猪的肝脏生长激素受体发育的影响。生理通讯，1996，15(增)：69
104. Anderson, J. B. Garner, S.C. Ambrose, W.W. and Ohue, T. 1996. Genistein and bone: studies in rat models and bone cell lines. Second international symposium on the role of soy in preventing and treating chronic disease. Brussels-Belgium. pp 19
105. Grossman, C.J., Interactions between the gonadal steroids and the immune system. Sci. 1985,227:257-261
106．刘林兰等。雌二醇对大鼠细胞免疫功能的影响。中国免疫学杂志。1992。8(2)：95-99
107．张荣庆(1993)。异黄酮植物雌激素对乳腺发育和免疫功能的作用及其神经内分泌的参与。南京农业大学博士生论文
108. E.LSamannoudy F.A. et al. 1980. Adverse effects of phytoestrogen: effect of beta-sitosterol treatment on follicular development, ovarian structure and uterus in the immature female sheep. Cell Molec. Biol. 26:255-266
109. Adlercreatz. H.et al.1982. Excretion of the lignans enterolactone and odiol and equol in omnivorous and vegetarian postrnenopausal women and in women with breast cancer. The Lancet. 11: 1295-1307
110．上海市医学化验所主编，1982。临床生化检验。上海科学技术出版社。pp102
111．上海市医学化验所主编，1982。临床生化检验。上海科学技术出版社。pp169
112．丁宏标，韩正康，陈杰。1996。日粮添加塞曼特罗(CIM)对大鼠生长胴体组成及GH水平的影响。动物学研究，17(3)：233-238。
113．秦为琳。1982。应用气相色谱测定瘤胃挥发性脂肪酸方法的研究改进。南京农业大学学报。4：110-115
114. Brodrick, G.A. and J.H.Kang. 1980. Automatrd simultaneous determination of ammonia and total amino acids in ruminal fluid and in vitro media. J.Dairy Sci. 63:64-75
115. Makkar, H.P.S., Sharma, O.P., Dawra, R.K., and S.S.Negi. 1982. Simple determinatiom of microbial protein in rureen liquor. J.Dairy Sci .65:2701-2713
116．蔡武城，袁厚积，1982，生物物质常用化学分析法。科学出版社，pp168-170
117．陆保年。1980。《常用临床检验意义》。江苏科学出版社。pp188
118．《兽医临床诊断学》。1979。东北农学院主编。农业出版社。pp222
119. Walton, P.E. et al. 1987. Exogenous Pituitary and recombinant growth hormones induce insulin and insulin-like growth hormone factor I resistance in pig adipose tissue. Domestic Animal Endocrinology 4:183-189
120. Walton. P.E. and Etherton. T.D.1987. The culture of adipose tissue explants in serum-free medium. Journal of Aimal Science 65(Supple.2) 25-30
121. Schofield. P.N. 1992. The insulin-like growth factors: structure and biological functions. Oxford University Press, New York, pp. 12-43
122. Froesch ER, Schmid C, Schwand J, et a1.1985. Actions of insulin-like growth factors. Ann Rev Physiol. 47:443-467
123. Gosteli-Peter M.A, Winterthalter K.H, Schmid C, et al.1994. Expression and regulation of insulin-llike growth factor-I (IGF-I)and IGF-I binding protein messenger ribonucleic acid levels in tissues of hypophyseetomized rats infused with IGF-Iand growth hormone .Endocrinology 135:2558-2567
124. Froesch ER, Schmid CH, ZangerI, et al. 1986. Effects of IGF/somatomedins on growth and differentiation of muscle and bone J Anita Sci.(suppl 2) 63:57-75
125. Maes M, Underwood, LE and Ketelslegers JM.1983. Plasma somatomedin-C in fasted and refed rats: close relationship with changes in liver, somatogenic but not laetogenic binding sites, J Endocrinology 97:243-252
126. Jocb RJ, Barrett. Pleqe. G. et al. 1989. Acute effects of insulin-like growth factor 1 on glucose and amino acid metabolism in the awake fasted rat. J Clin Invest. 83:1717-1723
127．韩正康，1993，《家畜营养生理学》农业出版社，pp.49-51
128. Schlechter. N.L, Russell. S.M, Spence. E.M, Nicoll. C.S. 1986. Evidence suggesting that the direct growth-promoting effect of GH on cartilage in vivo ismediated by local production of somatomedin .Proc Natl Acad Sci USA 83:7935-7934
129. Gopinath R and Etherton TD .1989. Effects of porcine growth hormone on glucose metabolism of pigs:Ⅱ.Glucose tolerance, peripheral tissue insulin sensitivity and glucose kinetics. J Anim Sci.67:689-697
130. Mersmann Harry J.1998.Overview of the effects of β-Adrenergic receptor agonists on animal growth including mechanisms of action. J.Animal Sci,76:169—172
131. 陆保年 1980。《常用临床检验意义》。江苏科学技术出版社。pp215
132. Setchell. K.D.R.et al. 1984, Nonsteroid estrogens of dietary origin: possible roles in hormone-dependent disease. Am.J. Clin.Nutr. 40:569-575
133. Jansson, J., Ekberg, S. Isaksson, O. Mode, A.and Gustafsson. J.1985. Imprinting of growth, and hepatic steroid metabolism by neonatal testosterone. Endocrinology. 117:1881-1890
134. Shelton, M. and Carpenter. Z.L. 1972. Influence of sex, stilbestrol treatment and slaughter weight on performance and carcass traits of slaughter lambs.J.Anim. Sci. 34:203-215
135. Dehaan, K.C., Berger, L.L.Kesler, D.J.McKeith, F.K. Thomas, D.L. and Nash,T.G.1987.Effect of prenatal androgenization on lamb performance.cacass composition and reproductive function. J.Anim. Sci. 65:1465-1470
136. Klindt, J., Jenkins, T.G. and Ford . J.J. 1986.Effect of prenatal androfen exposure on growth and the secretion of growth hormone (GH) and prolactin (PRL). J.Anim. Sci. 63 (Suppl. 1): 230(Abstr.)
137. Adlercrenutz H. 1990. Diet breast cancer and sex hormone metabolism anticarcinogenesis and radiation protection: Strategies in protection from radiation and cancer (O.f. Nygaard,ed.), Plenum press, New york, 18
138．潘同斌，韩正康。1991，氟安定、克伦特罗对绵羊摄食、消化率及复胃消化代谢的影响。硕士研究生毕业论文
139．刘宗柱，韩正康。1993，半胱胺对湖羊消化、代谢及外周血液中几种代谢激素水平的影响。硕士研究生毕业论文
2．周光宏 主编，1999，，肉品学。中国农业科技出版社，P52-54
3. Harvey, A.L. and Marshall. I. G. 1984, Muscle. In: Physiology and biochemistry of domestic fowl. Vol. 4, B.M.Freeman(ed), Academic Press.pp 219-222
4. Moss, F.P. 1986, The relationship between the dimensions of the fibers and the number of nuclri during growth of skeletal muscle in the fowl.Am.J.Anat. 122:555-561
5. Beermann, D.H. Effects of maternal dietary restriction during gestation and lactation, muscle sex and age on various indices of skeletal muscle growth in rats.J.Anim. Sci.57: 328. 1983.
6. Swenson M.J. editor. 1984.Duke'Physiology of Domestic Animals. Tenth Edition. Cornell University Press. pp 548-580
7. Sprncer, G.S.G. 1985,Hormonal systems regulating growth-a review. Anim. Sci.12:31-46
8．宋淑兰，1990，下丘脑促垂体激素和因子。神经内分泌学(谢启文主编)，辽宁科技出版社，pp．41-58
9. Brood, C.G.D. Hindmarsh P.C. and Stanhope R. 1988.Growth and growth hormone secretion (Review).J Edocrinol, 119(2): 179-184
10. Onneau, M. 1991. Regulation of pig growth by somatotropic hormone: I secretion and mode of action. Pig News and Information 12(1): 29-37
11. Etherton TD. 1989.The mechanisms by which porcine growth hormone improves pig growth performance.biotechnology in growth regulation. Heap RB and Prosser (Eds). C.G. Butterworths, London. 97-105
12. Brandsrna H A, Henken A.M et al. 1991. Effects of recombinant porcine somatotropin on metabolic rate in growing pigs. J Anim Sci, 69:2961—2970
13. Dunshea FR, Harris DM et al. 1992. Effect of porcine somatotropin on in vivo
glucose kinetics and lipogenesis in growing pigs. J Anim Sci.70:141-151
14． Magri K.A, Gopinath R and Etherton T.D.1987． Inhibition of lipogenic enzyme activities by porcine growth hormone (pGH) J Anim Sci, 65 (Suppl 1) :258
15． Hu C.Y. Novakofski J.E. and. Mersmann H. J. 1987． Hormonal control of porcine adipose tissue fatty acid release and cyclic cAMP concentration. J Anim Sci, 64: 1031-1037
16． Walton P.E and Etherton T.D. 1986． Stimulation of lipogenesis by insulin in swine adipose tissue: Antagonism by porcine growth hormone.J.Anim Sci. 62: 1584-1595
17． Walton P.E, Etherton T.D and Evock C.M. 1986． Antagonism of insulin action in cultured adipose tissue by pituitary and recombinant porcine growth hormone: potentiation by hydrocortisone. Endocrinology,118: 2577-2581
18． Isaksson OG, Lindahl A et al.1987． Mechanism of the stimulatory effect of growth hormone on the longitudinal bone growth. Endcrine Reviews. 8:426-438
19． Tomas F.M.Campbell R.G et al. 1992． Growth hormone increases whole-body Protein turnover in growing pigs, J Anim Sci. 70:3138-3143
20． Grant. A. L. et al. 1991． Administration of growth hormone to pigs alters the relative amount of insulin-like growth factor-Ⅰ mRNA in liver and sketetal muscle. J.Endocr.130: 331-338．
21． Dauhaday W.H and Rotweh.P. 1989． Insulin-like growth factors Ⅰ and Ⅱ peptide . messenger ribonucleic acid and gene structures. Serum. and tissue concentrations. Endocrine Reviews. 10: 68-91．
22． Owens, P. C et al. 1990 . Development changes in growth hormone, insulin-like growth factors (IGF-Ⅰ and IGF-Ⅱ) and IGF-binding proteins in plasma of young growing pigs, J. Endocr.128: 439-447．
23． Hizuka, N et al. 1986． Insulin-like growth factor I stimulate growth in normal growing rats. European J .of Pharmacol. 125: 143-150．
24． Dodson M.V et al .1985． Ovine somatomedin multiplication-stimulating activity, and insulin promote skeletal muscle satellite cell proliferation in
vitro. Endocr. 117,2357-2363．
25． Zadik .Z. et al. 1985． The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J.clin.Endocrinol. Metab. 60． 513-516．
26． Tannenbaum.G.S. et al.1985． The interreactionship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion Endocr.115:1952-1957．
27． Wehreubery, WB. et al. 1982． Inhibition of the pulsation secretion of growth hormone by monoclonal antibodies to the hypothalarnic growth hormone releasing factor (GRF). Endocr. 111: 2147-2148．
28． Vale, W. et al.1983． Effects of synthetic human pancreatic tumor GH releasing factor and somatotatin, triiodothronine and dexamethasone on GH secretion in vitro Endocr. 112: 1553-1555．
29． Edens. 1979． Age and sex-related differences in episodic growth hormone secretion in the rat.Endocr.105: 555-560．
30． Clark, R.G. et al .1989． Intravenous growth hormone response to patterned infusions in hypophysectomized rats J.Endocr. 104: 53-61
31． Oppenheimer J.H and Surks M.I. 975． Biochemical basis of thyroid hormone action. Biochemical actions of hormone (Vol Ⅲ).Litwack G (Ed). academic press , New York, 119-159．
32． Brent G.A, Moore D.D and Larsen P.R.1991． Thyroid hormone regulation of gene expression (Review). Annu Rev Physiol, 53:17-35．
33． Valcari R, Zini M and Portioli I.1992． Thyroid hormone and growth hormone secretion (Review). J Endocrinol Invest, 15(4) : 313-330．
34． Gray, D.G. et al. 1986, Implanting young bulls with zeranol from birth to four slaught ages Ⅲ growth performance and endocrine aspects. J.Anim.Sci.63: 747
35． Perston, R.L. 1975, Biological responses to estrogen abbitives in maet produing cattle and lamds. J.Anim.Sci.44: 1414
36． Johson, B.H. et al .1982, Suppression of luteinzing hormone and testosterone
secretion in bulls following ACTH treatment. Biol. Reprod.26:305-312
37. Thomas, K.M.andRodway. R.G. 1983, Adrenal function in lambs implanted with trenbolone acetate plus oestradiol or with trenbolone acetate alone.Anim.prod.36:529
38. Henricks, D.M. et al. 1984,Sex difference in plasma in cortisol and growth in the bovine.Janim. Sci.59:376
39. Breier,B.H. et al.1988, The somatotrophic axis in young steers:influence of nutritional status and oestradiol-17 βon hepatic high-and low-affinity somatotrophi? binding sites. J.Endocrin. 116:169
40. 韩正康，陈杰主编．1988．反刍动物瘤胃的消化和代谢．科学出版社．pp64-79
41. Hino, T. And Russell. J.B. 1987. Relation contributions of ruminal bacteria and protozoa to the degradation of protein in vitro. J.Anim. Sci. 64:261—270.
42. Wallace, R.J. and Brammall. M. L. 1985. The rate of different species of bacteria in the hydrolysis of protein in the rumen. J.Gen. Microbiol. 131:821.
43. Maxshall and Stern, D.et al. 1979. Methods for determining and factors affecting rumen microbial protein synthesis: a review. J.Anim. Sci. 49:1590—1603.
44. Broderick, G.A. and Wallace. R.J. 1988. Effects of dietary nitrogen source on concentrations of ammonia, free amino acids and fluorescamine reactive peptides in the sheep rumen. J.Anim. Sci. 66: 2233—2238.
45．杨国宇．1994．睾酮调控瘤胃消化代谢的研究．南京农业大学博士论文。
46．蔡天权，韩正康，陈伟华，陈杰。1990。17β-雌二醇对瘤胃消化代谢调节的研究。南京农业大学学报。13(4 增)：131-136。
47．王金洛，韩正康，陈杰。1990。孕酮调节消化代谢的研究。南京农业大学学报。14(2)：74-78。
48. Fox,M.T.etal.1989.Effect of omeprazole treatment on food intake and blood gastrin and pepsinogen levels in the calf.Res.Vet.Sci.46:280-288
49．余雄。1994。反刍动物瘤胃和十二指肠内容物肽类和胃泌素含量变化的研究。南京农业大学硕士论文。
50．沈赞明，陈杰，陈伟华。1999，五肽胃泌素对瘤胃微生物代谢的影响。动物营养学报。11(增)：269-270
51. Kennedy, P.M.et al. 1997.Studies on relationship between thyroid function, cold acclimation and retention in time of digesta in sheep. J.Anim. Sci.45:1084-1090.
52．华刚，韩正康。1990。甲状腺片或甲基硫脲嘧啶对血液甲状腺激素及瘤胃代谢的影响。南京农业大学学报。13(增)：125-130。
53. Randall L.O. 1960. Pharmacology of methaminodiazepoxide. Dis Nerv Syst. 21:7—15
54. Bail C.A and McLanghlin C.L. 1979. A review of the behavioral and Physiological responses to elfazepam,a chemical feed intake stimulant. J.Anim Sci.49(5):1371—1395
55．姜洪林，韩正康。1993。苯二氮卓类化合物F89对大鼠、肉鸡摄食和增重的影响。南京农业大学学报，16(增刊)：9-14。
56．丁宏标，韩正康等。1997。苯二氮卓化合物F89对猪的生长胴体组成组成和养分代谢的影响。中国农业科学。30(5)：75-80
57. Han Zengkang, Ge shenfang and Lu Tianshui 1992 studies on improving theperformance of chinese Langshan chicken by neuroendocrine control.The sixth animal Science Congress of Asian-Australian association of animal production societies (AAAP), Bangkok,Tailand.
58．葛盛芳等。1999。克伦特罗和苯二氮卓化合物F89对肉鸡生长、胴体组成和血液代谢物的影响。南京农业大学学报。22(1)：73-76
59. Dinus,D.A. and Baile,C.A. 1997, Beef cattle responses to a feed intake stimulate given along and in combination with a propionate enhancer. J.Anim. Sci. 45:147-153
60. Della Fera, M.A., Mclaughlin, C.L. Weston. R.H.1977, Rumen function during elfazepam and 9-aza-cannabinol elicited feeding in sheep. Fed. Proc.36:1141 (Abstr.4600)
61．潘同斌，韩正康。1993，F89对湖羊摄食、消化率及复胃消化代谢的影响。南京农业大学学报。16(增)：35-40
62. Klotz U.1991. Occurrence of "natural" benzodiazepines. Life sci,48:209—215
63．朱国庆。1993．苯二氮卓和γ-氨基丁酸A／苯二氮卓／氯离子通道复合物。生理科学进展。24(2)，145-148
64．颜光美。1990．中枢型苯二氮卓受体研究．生理科学进展，21(3)：258—259
65. Sander DJ. 1985. Minireview. GABA and behavioral effects of anxiolytic drugs Life Sci, 36:1503—1513
66．姜洪林，韩正康．1992，侧脑室注射氟安定对家兔摄食的影响。中国应用生理学杂志。8(1)：77～78
67．赵茹茜，韩正康．1993。F89对鹅摄食和血浆胰岛素、β-内啡肽水平的影响。南京农业大学学报。16(增)：1-4
68. Selye,H. and Szabo. S.1973. An experimental model for the production of perforating duodenal ulcers by cysteamine in the rat. Nature.244: 258.
69. Millard, W.J. Sager, S. M, Badger, T.M and Martin. S. B. 1983. Cysteamine effects on growth hormone secretion in the male rat. Endocrinology. 112:509—517.
70．林玲，韩正康。1991。生长抑素抑制剂-半胱胺促进大鼠、幼兔生长的研究。中国应用生理学杂志。7(4)：345-347
71．韩正康，林玲。1992。生长抑素抑制剂-半胱胺促进肉用仔鸡生长的研究。畜牧兽医学报。23(4)：314-318
72．刘皙洁，韩正康，1997。半胱胺颗粒料促进羔羊增重的实验。黑龙江畜牧兽医。11：9～11
73．刘皙洁，韩正康等。1998。半胱胺对香猪胃液分泌、血液胃泌素和生长抑素水平的影响。畜牧与兽医。30(3)：105-107
74．王艳玲等。1997。半胱胺促进绵羊生长的实验研究。全国动物生理生化第五次学术会议论文摘要汇编。P106
75．丁宏标、陈杰、韩正康。1994，CS87促进猪生长的研究。南京农业大学学报。17(4)：87～91
76．王艳玲、陈伟华、韩正康。1997。不同剂量半胱胺对肉用仔鸡增重及血液生长抑素、生长激素含量的影响。中国畜牧兽医杂志。33(4)：11-13
77．王子荣，陈杰等。1999。半胱胺和生长抑素基因工程苗对反刍动物消化、代谢和生长的影响及作用机理研究。博士研究生毕业论文
78．刘宗柱，韩正康。1996。去势及灌注半胱胺对湖羊消化、代谢的影响。南京农业大学学报。19(2)：54-58
79．刘宗柱，沈延法，韩正康。1996。半胱胺对绵羊消化代谢的影响。畜牧兽医学报。27(3)：212-219
80．韩正康等。1996。半胱胺引起绵羊外周血液β-内啡肽和几种主要代谢激素的变化。畜牧兽医学报。27(3)：193-198
81. William J.M et al.1983.Cysteamine effects on growth hormone secretion in the male rat. Endocrinology, 112:509—517
82. Williams. P.E.V.1987, The use of β-agonists as a maens of altering body composition in livestock species. Nutrition Abtracts and Reviews (Serie B).57:453-464
83. Baker,P.K., Dalrymple, R.H., Ingle,D.L, Ricks,C.A.1984,Use of a β-adrenergic agonist to alter muscle and fat deposition in lamds.J.Anim. Sci.59:1256-1261
84. Ricks, C.A., Baker, P.K., Dalrymple, R.H. 1984. Use of clenbuterol to alter muscle and fat accretation in swine. Fed. Proc.43:857
85. Dalrymple, R.H. baker, P.K., Ginger, P.E. 1984. A repartitioning agent to improve performance and carcass composition of broilers. Poultry Sci .63:2376-2383
86. Maltin, C.A., Delday, M.I., Reeds, P.J. 1986,The effect of a growth promoting drug clenbuterol on fibre frequency and area in hind limd muscles from young male rats. Bioscience Reports.6:293
87. Williams, P.E.V., Pagliani, L. Innes,G.M. 1987, Effects of a β-agonist(clenbuterol) on growth, carcass composition, protein and energy metabolism of veal calves. British Journal of Nutrition,57:417-428
88. Emery,P.W., Rothwell, N.J., Stock, M.J. Winter, P.D. 1984 Chornic effects of β-adrenergic agonists on body composition and protein synthesis in the rat.Bioscienee Reports,4:83-92
89. Beermann, D.H. Butler, W.E. Hogue. D. E. 1987, Cimaterol-induced muscle hypertrophy and alterd endocrine status in lambs.J.Anim.Sci.65:1514-1524
90．姜卫红，韩正康，陈杰，1990，β-肾上腺素能激动剂克伦特罗对瘤胃微生物蛋白质分解作用的影响。全国动物生理生化第二次学术会议论文摘要汇编。1990年10月于山东烟台。
91. Terry, L.C. and Craig. R. 1985. Cysteamine effects on menoamines, dopamine β-hydroxylase and hypothalamic-pituitary axis (Abstr). Neuroendocrinology.41(6): 467
92．朱祖康，韩正康。1992。β-肾上腺素能激动剂克伦特罗对湖羊消化代谢的影响。全国动物生理生化第三次学术会议论文摘要汇编。1992年10月于四川成都。
93. Mersmann Harry J. 1998. Overview of the effects of β-Adrenergic receptor agonists on animal growth including mechanisms of action. J.Animal Sci,76:160—172
94. Squires E.J,Adeolao,et al.1993.The role of growth hormones,β-Adrenergic agents and intact males in pork production: A review. Can. J. Animal Sci,73(1): 1—23
95．王国杰，韩正康，陈伟华。1995。大豆黄酮对大鼠肌肉生长和几种内源激素水平的影响。动物学研究。16(1)：23-29
96．王国杰等。1994。大豆黄酮对肉鸡生长的影响及其作用机制的研究。广东畜牧兽医科技。19(3)：3-4
97．赵志辉，陆天水。1997。大豆黄酮对猪生长的影响及其神经内分泌机理研究。硕士研究生毕业论文
98．王国杰，韩正康。1993。克伦特罗和异黄酮植物雌激素对骨骼肌细胞生长的影响。南京农业大学学报。16(增刊)：15～18
99．王国杰。1992。异黄酮植物雌激素对肌肉生长的影响及作用机制的研究。博士研究生毕业论文
100．谢启文主编 1990。神经内分泌学 辽宁科学技术出版社 53：185
101. Arimandi, B.H. Getlinger, M.J. Goyal, N.V. Birbaum. I.R. 1996. A soy proteincontaining diet prevents bone loss due to ovarian hormone deficiency. Second international symposium on the role of soy in preventing and treating chronic disease.Brussels-Belgium.pp19
102．张荣庆，韩正康。异黄酮植物激素IFD对胎儿生长的影响。生理通讯，1993，12(增)：153
103．刘根桃，陈伟华，陈杰等。妊娠后期母猪饲喂大豆黄酮对哺乳仔猪的肝脏生长激素受体发育的影响。生理通讯，1996，15(增)：69
104. Anderson, J. B. Garner, S.C. Ambrose, W.W. and Ohue, T. 1996. Genistein and bone: studies in rat models and bone cell lines. Second international symposium on the role of soy in preventing and treating chronic disease. Brussels-Belgium. pp 19
105. Grossman, C.J., Interactions between the gonadal steroids and the immune system. Sci. 1985,227:257-261
106．刘林兰等。雌二醇对大鼠细胞免疫功能的影响。中国免疫学杂志。1992。8(2)：95-99
107．张荣庆(1993)。异黄酮植物雌激素对乳腺发育和免疫功能的作用及其神经内分泌的参与。南京农业大学博士生论文
108. E.LSamannoudy F.A. et al. 1980. Adverse effects of phytoestrogen: effect of beta-sitosterol treatment on follicular development, ovarian structure and uterus in the immature female sheep. Cell Molec. Biol. 26:255-266
109. Adlercreatz. H.et al.1982. Excretion of the lignans enterolactone and odiol and equol in omnivorous and vegetarian postrnenopausal women and in women with breast cancer. The Lancet. 11: 1295-1307
110．上海市医学化验所主编，1982。临床生化检验。上海科学技术出版社。pp102
111．上海市医学化验所主编，1982。临床生化检验。上海科学技术出版社。pp169
112．丁宏标，韩正康，陈杰。1996。日粮添加塞曼特罗(CIM)对大鼠生长胴体组成及GH水平的影响。动物学研究，17(3)：233-238。
113．秦为琳。1982。应用气相色谱测定瘤胃挥发性脂肪酸方法的研究改进。南京农业大学学报。4：110-115
114. Brodrick, G.A. and J.H.Kang. 1980. Automatrd simultaneous determination of ammonia and total amino acids in ruminal fluid and in vitro media. J.Dairy Sci. 63:64-75
115. Makkar, H.P.S., Sharma, O.P., Dawra, R.K., and S.S.Negi. 1982. Simple determinatiom of microbial protein in rureen liquor. J.Dairy Sci .65:2701-2713
116．蔡武城，袁厚积，1982，生物物质常用化学分析法。科学出版社，pp168-170
117．陆保年。1980。《常用临床检验意义》。江苏科学出版社。pp188
118．《兽医临床诊断学》。1979。东北农学院主编。农业出版社。pp222
119. Walton, P.E. et al. 1987. Exogenous Pituitary and recombinant growth hormones induce insulin and insulin-like growth hormone factor I resistance in pig adipose tissue. Domestic Animal Endocrinology 4:183-189
120. Walton. P.E. and Etherton. T.D.1987. The culture of adipose tissue explants in serum-free medium. Journal of Aimal Science 65(Supple.2) 25-30
121. Schofield. P.N. 1992. The insulin-like growth factors: structure and biological functions. Oxford University Press, New York, pp. 12-43
122. Froesch ER, Schmid C, Schwand J, et a1.1985. Actions of insulin-like growth factors. Ann Rev Physiol. 47:443-467
123. Gosteli-Peter M.A, Winterthalter K.H, Schmid C, et al.1994. Expression and regulation of insulin-llike growth factor-I (IGF-I)and IGF-I binding protein messenger ribonucleic acid levels in tissues of hypophyseetomized rats infused with IGF-Iand growth hormone .Endocrinology 135:2558-2567
124. Froesch ER, Schmid CH, ZangerI, et al. 1986. Effects of IGF/somatomedins on growth and differentiation of muscle and bone J Anita Sci.(suppl 2) 63:57-75
125. Maes M, Underwood, LE and Ketelslegers JM.1983. Plasma somatomedin-C in fasted and refed rats: close relationship with changes in liver, somatogenic but not laetogenic binding sites, J Endocrinology 97:243-252
126. Jocb RJ, Barrett. Pleqe. G. et al. 1989. Acute effects of insulin-like growth factor 1 on glucose and amino acid metabolism in the awake fasted rat. J Clin Invest. 83:1717-1723
127．韩正康，1993，《家畜营养生理学》农业出版社，pp.49-51
128. Schlechter. N.L, Russell. S.M, Spence. E.M, Nicoll. C.S. 1986. Evidence suggesting that the direct growth-promoting effect of GH on cartilage in vivo ismediated by local production of somatomedin .Proc Natl Acad Sci USA 83:7935-7934
129. Gopinath R and Etherton TD .1989. Effects of porcine growth hormone on glucose metabolism of pigs:Ⅱ.Glucose tolerance, peripheral tissue insulin sensitivity and glucose kinetics. J Anim Sci.67:689-697
130. Mersmann Harry J.1998.Overview of the effects of β-Adrenergic receptor agonists on animal growth including mechanisms of action. J.Animal Sci,76:169—172
131. 陆保年 1980。《常用临床检验意义》。江苏科学技术出版社。pp215
132. Setchell. K.D.R.et al. 1984, Nonsteroid estrogens of dietary origin: possible roles in hormone-dependent disease. Am.J. Clin.Nutr. 40:569-575
133. Jansson, J., Ekberg, S. Isaksson, O. Mode, A.and Gustafsson. J.1985. Imprinting of growth, and hepatic steroid metabolism by neonatal testosterone. Endocrinology. 117:1881-1890
134. Shelton, M. and Carpenter. Z.L. 1972. Influence of sex, stilbestrol treatment and slaughter weight on performance and carcass traits of slaughter lambs.J.Anim. Sci. 34:203-215
135. Dehaan, K.C., Berger, L.L.Kesler, D.J.McKeith, F.K. Thomas, D.L. and Nash,T.G.1987.Effect of prenatal androgenization on lamb performance.cacass composition and reproductive function. J.Anim. Sci. 65:1465-1470
136. Klindt, J., Jenkins, T.G. and Ford . J.J. 1986.Effect of prenatal androfen exposure on growth and the secretion of growth hormone (GH) and prolactin (PRL). J.Anim. Sci. 63 (Suppl. 1): 230(Abstr.)
137. Adlercrenutz H. 1990. Diet breast cancer and sex hormone metabolism anticarcinogenesis and radiation protection: Strategies in protection from radiation and cancer (O.f. Nygaard,ed.), Plenum press, New york, 18
138．潘同斌，韩正康。1991，氟安定、克伦特罗对绵羊摄食、消化率及复胃消化代谢的影响。硕士研究生毕业论文
139．刘宗柱，韩正康。1993，半胱胺对湖羊消化、代谢及外周血液中几种代谢激素水平的影响。硕士研究生毕业论文
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