牛初级卵泡体外培养体系的建立和miR-27a在小鼠颗粒细胞中的功能的研究
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摘要
体外培养145-170gm牛腔前卵泡能够形成卵泡腔已有人报道,但体外培养50-70μm的牛初级卵泡能否发育成腔仍没有报道。为了建立适合牛初级卵泡体外生长发育的培养体系,同时进一步揭示牛腔前卵泡体外发育的相关机制,本实验以屠宰场获取的牛卵巢为材料,以机械分离法获取直径50-70μm的牛初级卵泡,以α-MEM为基础培养基,调整不同浓度促卵泡素(FSH)、促黄体素(LH)和雌二醇(E2)激素配比以及优化碱性成纤维生长因子(bFGF)和表皮生长因子(EGF)添加量等试验,使用胶原包被的三维培养方法对牛初级卵泡进行体外培养13或21天(d),观察卵泡直径以及成腔的变化,并用Real-Time PCR检测卵泡发育及成熟相关基因：芳香化酶(CYP19A1)、抗缪勒激素(AMH)、生长分化因子9(GDF-9)、骨形成蛋白15(BMP-15)以及m型转化生长因子p受体(TGFβR3)的表达。结果发现,以α-MEM为基础培养基,0.25μg/mL FSH+5IU/mL LH+0.1μg/mL E2+50ng/mL bFGF组以及FSH+LH+E2+bFGF和25ng/mL EGF联合处理组卵泡直径在体外培养21d时显著高于其他组(p<0.05),并且在培养第19d和17d形成小的卵泡腔,成腔率分别为16.7%和33.3%。卵泡发育、成熟相关基因CYP19A1,AMH, GDF-9,BMP-15和TGFβR3的表达也有显著变化。综上,我们建立了一套有效的体外促进牛初级卵泡生长和成熟的培养体系,即α-MEM+FSH(0.25μg/mL)+LH(5IU/mL)+E2(0.1μg/mL)+bFGF(50ng/mL)+EGF(25ng/mL);
MicroRNA(miRNA)是近年来发现的一类长度为20-25nt的小干扰RNA,它通过对基因的转录后调控,在细胞的增殖、分化、凋亡等方面发挥重要作用。本实验在之前牛初级卵泡培养的基础上,发现miR-27a在牛卵巢中表达较高,但由于条件限制,我们利用小鼠模型来探讨miR-27a对颗粒细胞功能的影响。我们发现,miR-27a在小鼠腔前卵泡颗粒细胞中表达较高,但在有腔卵泡颗粒细胞中表达明显下降。因此,本实验通过体外高效转染技术,将miR-27a模拟物(mimics)和抑制剂(inhibitor)转入小鼠颗粒细胞中,利用Real-Time PCR、流式细胞术等实验方法检测miR-27a和相关基因的表达以及观察其对颗粒细胞增殖和激素分泌的影响。结果发现：miR-27a有促进颗粒细胞凋亡、抑制颗粒细胞增殖、抑制颗粒细胞分泌雌激素的功能,它可能是通过下游的靶基因CREB1来影响颗粒细胞的凋亡和雌激素分泌,但具体机理还需进一步验证。
Successful antral formation in vitro from bovine preantral follicles (145-170μm) has been described previously, but antrum formation from the primary follicle (50-70μm) has not yet been achieved in vitro. In order to establish the optimal bovine primary follicle culture system in vitro and investigate the related mechanisms. Primary follicles (50-70μm) were dissected from bovine ovaries, and cultured in a three-dimensional culture system for13or21days in alpha-minimum essential medium (a-MEM). Various treatments including follicle stimulating hormone (FSH), luteinizing hormone (LH),17β-estradiol (E2), basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) were tested. The follicular diameter and antrum formation rate were recorded, and follicular maturation markers (P450aromatase, CYP19A1; anti-Mullerian hormone, AMH; growth differentiation factor-9, GDF-9; bone morphogenetic protein-15, BMP-15; and type III transforming growth factor P receptor, TGFβR3) were analyzed by Real-Time RT-PCR. After21days of culture under each treatment condition, the follicular diameter was significantly enlarged in the presence of FSH+LH+E2+bFGF or FSH+LH+E2+bFGF+EGF (p<0.05). An addition of50ng/mL bFGF or bFGF+25ng/mL EGF initiated antrum formation by day19and day17of culture, and the antral cavity formation rate was16.7%and33.3%by21days of culture, respectively. The expression of follicular maturation markers (CYP19A1, AMH, GDF-9, BMP-15and TGFPR3) was significantly altered. We conclude that addition of50ng/mL bFGF+25ng/mL EGF to media containing FSH+LH+E2turned out to be the most effective optimized culture conditions to support the growth and maturation of bovine primary follicles in vitro.
MicroRNAs (miRNAs) are a class of small (20-25nt) non-coding RNAs which function in gene post-transcriptional regulation with important roles in cell proliferation, differentiation and apoptosis. Based on our previous bovine primary follicle culture study, we observed that expression of miR-27a was abundant in bovine ovary. We investigated the molecular function of miR-27a in mouse granulosa cell. Our results showed that expression of miR-27a in mouse preantral follicles granulose cell was higher than the expression in antral follicles granulose cell. After transfected miR-27a mimics and its inhibitor into mouse granulosa cells, we found that miR-27a played a important role in suppressing granulosa cells proliferation, promoting granulosa cell apoptosis and inhibiting estrogen secretion, and these effects were mainly by targeting transcriptional factor CREB1.
MicroRNA(miRNA)是近年来发现的一类长度为20-25nt的小干扰RNA,它通过对基因的转录后调控,在细胞的增殖、分化、凋亡等方面发挥重要作用。本实验在之前牛初级卵泡培养的基础上,发现miR-27a在牛卵巢中表达较高,但由于条件限制,我们利用小鼠模型来探讨miR-27a对颗粒细胞功能的影响。我们发现,miR-27a在小鼠腔前卵泡颗粒细胞中表达较高,但在有腔卵泡颗粒细胞中表达明显下降。因此,本实验通过体外高效转染技术,将miR-27a模拟物(mimics)和抑制剂(inhibitor)转入小鼠颗粒细胞中,利用Real-Time PCR、流式细胞术等实验方法检测miR-27a和相关基因的表达以及观察其对颗粒细胞增殖和激素分泌的影响。结果发现：miR-27a有促进颗粒细胞凋亡、抑制颗粒细胞增殖、抑制颗粒细胞分泌雌激素的功能,它可能是通过下游的靶基因CREB1来影响颗粒细胞的凋亡和雌激素分泌,但具体机理还需进一步验证。
Successful antral formation in vitro from bovine preantral follicles (145-170μm) has been described previously, but antrum formation from the primary follicle (50-70μm) has not yet been achieved in vitro. In order to establish the optimal bovine primary follicle culture system in vitro and investigate the related mechanisms. Primary follicles (50-70μm) were dissected from bovine ovaries, and cultured in a three-dimensional culture system for13or21days in alpha-minimum essential medium (a-MEM). Various treatments including follicle stimulating hormone (FSH), luteinizing hormone (LH),17β-estradiol (E2), basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) were tested. The follicular diameter and antrum formation rate were recorded, and follicular maturation markers (P450aromatase, CYP19A1; anti-Mullerian hormone, AMH; growth differentiation factor-9, GDF-9; bone morphogenetic protein-15, BMP-15; and type III transforming growth factor P receptor, TGFβR3) were analyzed by Real-Time RT-PCR. After21days of culture under each treatment condition, the follicular diameter was significantly enlarged in the presence of FSH+LH+E2+bFGF or FSH+LH+E2+bFGF+EGF (p<0.05). An addition of50ng/mL bFGF or bFGF+25ng/mL EGF initiated antrum formation by day19and day17of culture, and the antral cavity formation rate was16.7%and33.3%by21days of culture, respectively. The expression of follicular maturation markers (CYP19A1, AMH, GDF-9, BMP-15and TGFPR3) was significantly altered. We conclude that addition of50ng/mL bFGF+25ng/mL EGF to media containing FSH+LH+E2turned out to be the most effective optimized culture conditions to support the growth and maturation of bovine primary follicles in vitro.
MicroRNAs (miRNAs) are a class of small (20-25nt) non-coding RNAs which function in gene post-transcriptional regulation with important roles in cell proliferation, differentiation and apoptosis. Based on our previous bovine primary follicle culture study, we observed that expression of miR-27a was abundant in bovine ovary. We investigated the molecular function of miR-27a in mouse granulosa cell. Our results showed that expression of miR-27a in mouse preantral follicles granulose cell was higher than the expression in antral follicles granulose cell. After transfected miR-27a mimics and its inhibitor into mouse granulosa cells, we found that miR-27a played a important role in suppressing granulosa cells proliferation, promoting granulosa cell apoptosis and inhibiting estrogen secretion, and these effects were mainly by targeting transcriptional factor CREB1.
引文
Abel, M.H., Wootton, A.N., Wilkins, V., Huhtaniemi, I., Knight, P.G, and Charlton, H.M. (2000). The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology 141,1795-1803.
Abir, R., Fisch, B., Nitke, S., Okon, E., Raz, A., and Ben Rafael, Z. (2001). Morphological study of fully and partially isolated early human follicles. Fertil Steril 75,141-146.
Abir, R., Franks, S., Mobberley, M.A., Moore, P.A., Margara, R.A., and Winston, R.M.L. (1997). Mechanical isolation and in vitro growth of preantral and small antral human follicles. Fertil Steril 68,682-688.
Abir, R., Orvieto, R., Dicker, D., Zukerman, Z., Barnett, M., and Fisch, B. (2002). Preliminary studies on apoptosis in human fetal ovaries. Fertil Steril 78,259-264.
Abir, R., Roizman, P., Fisch, B., Nitke, S., Okon, E., Orvieto, R., and Ben Rafael, Z. (1999). Pilot study of isolated early human follicles cultured in collagen gels for 24 hours. Hum Reprod 14,1299-1301.
Adam, A., Takahashi, Y., Katagiri, S., and Nagano, M. (2004). In vitro culture of mouse preantral follicles using membrane inserts and developmental competence of in vitro ovulated oocytes. J Reprod Develop 50,579.
Adashi, E., and Hsueh, A. (1982). Estrogens augment the stimulation of ovarian aromatase activity by follicle-stimulating hormone in cultured rat granulosa cells. J Biol Chem 257,6077-6083.
Adashi, E.Y., Resnick, C.E., Hernandez, E.R., May, J.V., Purchio, A.F., and Twardzik, D.R. (1989). Ovarian transforming growth factor-beta (tgf-beta)-cellular site(s), and mechanism(s) of action. Mol Cell Endocrinol 61,247-256.
Adhikari, D., Zheng, W., Shen, Y., Gorre, N., Hamalainen, T., Cooney, A.J., Huhtaniemi, I., Lan, Z.J., and Liu, K. (2010). Tsc/mTORCl signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet 19,397-410.
Adriaens, I., Cortvrindt, R., and Smitz, J. (2004). Differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence. Hum Reprod 19,398-408.
Alak, B.M., Coskun, S., Friedman, C.I., Kennard, E.A., Kim, M.H., and Seifer, D.B. (1998). Activin A stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro. Fertil Steril 70,1126-1130.
Alak, B.M., Smith, G.D., Woodruff, T.K., Stouffer, R.L., and Wolf, D.P. (1996). Enhancement of primate oocyte maturation and fertilization in vitro by inhibin A and activin A. Fertil Steril 66,646-653.
Amanai, M., Brahmajosyula, M., and Perry, A.C. (2006). A restricted role for sperm-borne microRNAs in mammalian fertilization. Biol Reprod 75,877-884.
Armstrong, D.G., Baxter, G, Hogg, C.O., and Woad, K.J. (2002). Insulin-like growth factor (IGF) system in the oocyte and somatic cells of bovine preantral follicles. Reproduction 123,789-797.
Baerwald, A.R., Adams, GP., and Pierson, R.A. (2003). Characterization of ovarian follicular wave dynamics in women. Biol Reprod 69,1023-1031.
Baker, S.J., Srsen, V., Lapping, R., and Spears, N. (2001). Combined effect of follicle-follicle interactions and declining follicle-stimulating hormone on murine follicle health in vitro. Biol Reprod 65, 1304-1310.
Baker, T.G. (1963).A quantitative and cytological study of germ cells in human ovaries. P Roy Soc B-Biol Sci 158,417-420.
Baker, T.G, and Neal, P. (1974). Organ-culture of cortical fragments and graafian follicles from human ovaries. J Anat 117,361-371.
Bartel, D.P. (2004). MicroRNAs:genomics, biogenesis, mechanism, and function. Cell 116,281-297.
Baulcombe, D. (2002). DNA events. An RNA microcosm. Science 297,2002-2003.
Beaujean, N., Hartshorne, G., Cavilla, J., Taylor, J., Gardner, J., Wilmut, I., Meehan, R., and Young, L. (2004). Non-conservation of mammalian preimplantation methylation dynamics. Curr Biol 14, R266-267.
Berkholtz, C.B., Shea, L.D., and Woodruff, T.K. (2006). Extracellular matrix functions in follicle maturation. Semin Reprod Med 24,262-269.
Bernstein, E., Caudy, A.A., Hammond, S.M., and Hannon, G.J. (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409,363-366.
Biggers, J.D., Whittingham, D.G., and Donahue, R.P. (1967). The pattern of energy metabolism in the mouse oocyte and zygote. Proc Natl Acad Sci U S A 58,560-567.
Bissell, M.J., Rizki, A., and Mian, I.S. (2003). Tissue architecture:the ultimate regulator of breast epithelial function. Curr Opin Cell Biol 15,753-762.
Blandau, R.J., Warrick, E., and Rumery, R.E. (1965). In vitro cultivation of fetal mouse ovaries. Fertil Steril 16,705-715.
Boland, N.I., and Gosden, R.G. (1994). Effects of epidermal growth factor on the growth and differentiation of cultured mouse ovarian follicles. J Reprod Fertil 101,369-374.
Boland, N.I., Humpherson, P.G, Leese, H.J., and Gosden, R.G. (1993). Pattern of lactate production and steroidogenesis during growth and maturation of mouse ovarian follicles invitro. Biol Reprod 48, 798-806.
Borghol, N., Lornage, J., Blachere, T., Garret, A.S., and Lefevre, A. (2006). Epigenetic status of the H19 locus in human oocytes following in vitro maturation. Genomics 87,417-426.
BrawTal, R., and Yossefi, S. (1997). Studies in vivo and in vitro on the initiation of follicle growth in the bovine ovary. J Reprod Fertil 109,165-171.
Bukowski, R.M., Olencki, T., McLain, D., and Finke, J.H. (1994). Pleiotropic effects of cytokines:clinical and preclinical studies. Stem Cells 12 Suppl 1,129-140; discussion 140-121.
Cain, L., Chatterjee, S., and Collins, T.J. (1995). In-vitro folliculogenesis of rat preantral follicles. Endocrinology 136,3369-3377.
Campbell, B.K., Scaramuzzi, R.J., and Webb, R. (1996). Induction and maintenance of oestradiol and immunoreactive inhibin production with FSH by ovine granulosa cells cultured in serum-free media. J Reprod Fertil 106,7-16.
Carabatsos, M.J., Elvin, J., Matzuk, M.M., and Albertini, D.F. (1998). Characterization of oocyte and follicle development in growth differentiation factor-9-deficient mice. Dev Biol 204,373-384.
Carambula, S.F., Goncalves, P.B.D., Costa, L.F.S., Figueiredo, J.R., Wheeler, M.B., Neves, J.P., and Mondadori, R.G (1999). Effect of fetal age and method of recovery on isolation of preantral follicles from bovine ovaries. Theriogenology 52,563-571.
Carletti, M.Z., Fiedler, S.D., and Christenson, L.K. (2010). MicroRNA 21 Blocks Apoptosis in Mouse Periovulatory Granulosa Cells. Biol Reprod 83,286-295.
Carmell, M.A., and Hannon, G.J. (2004). RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol 11,214-218.
Carroll, J., and Gosden, R.G. (1993). Transplantation of frozen-thawed mouse primordial follicles. Hum Reprod 8,1163-1167.
Carroll, J., Whittingham, D.G, and Wood, M.J. (1991a). Effect of dibutyryl cyclic adenosine-monophosphate on granulosa-cell proliferation, oocyte growth and meiotic maturation in isolated mouse primary ovarian follicles cultured in collagen gels. J Reprod Fertil 92,197-207.
Carroll, J., Whittingham, D.G., and Wood, M.J. (1991b). Growth-invitro and acquisition of meiotic competence after the cryopreservation of isolated mouse primary ovarian follicles. Reprod Fert Develop 3,593-599.
Castrillon, D.H., Miao, L.L., Kollipara, R., Horner, J.W., and DePinho, R.A. (2003). Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301,215-218.
Cecconi, S., Barboni, B., Coccia, M., and Mattioli, M. (1999). In vitro development of sheep preantral follicles. Biol Reprod 60,594-601.
Cecconi, S., Rossi, G, Coticchio, G., Macchiarelli, G., Borini, A., and Canipari, R. (2004). Influence of thyroid hormone on mouse preantral follicle development in vitro. Fertil Steril 81,919-924.
Chang, S.C.S., Anderson, W., Lewis, J.C., Ryan, R.J., and Kang, Y.H. (1977). Porcine ovarian follicle.2. electron-microscopic study of surface features of granulosa-cells at different stages of development. Biol Reprod 16,349-357.
Chegini, N., and Flanders, K.C. (1992). Presence of transforming growth-factor-beta and their selective cellular-localization in human ovarian tissue of various reproductive stages. Endocrinology 130, 1707-1715.
Cheng, L., Gearing, D.P., White, L.S., Compton, D.L., Schooley, K., and Donovan, P.J. (1994). Role of leukemia inhibitory factor and its receptor in mouse primordial germ cell growth. Development 120, 3145-3153.
Cho, J.-H., Itoh, T., Sendai, Y, and Hoshi, H. (2008). Fibroblast Growth Factor 7 Stimulates In Vitro Growth of Oocytes Originating From Bovine Early Antral Follicles. Mol Reprod Dev 75,1736-1743.
Clark, A.R., Stokes, Y.M., Lane, M., and Thompson, J.G (2006). Mathematical modelling of oxygen concentration in bovine and murine cumulus-oocyte complexes. Reproduction 131,999-1006.
Conti, M., Andersen, C.B., Richard, F., Mehats, C., Chun, S.Y., Horner, K., Jin, C., and Tsafriri, A. (2002). Role of cyclic nucleotide signaling in oocyte maturation. Mol Cell Endocrinol 187,153-159.
Cortvrindt, R., Hu, Y, and Smitz, J. (1998). Recombinant luteinizing hormone as a survival and differentiation factor increases oocyte maturation in recombinant follicle stimulating hormone-supplemented mouse preantral follicle culture. Hum Reprod 13,1292-1302.
Cortvrindt, R., Smitz, J., and VanSteirteghem, A.C. (1996). In-vitro maturation, fertilization and embryo development of immature oocytes from early preantral follicles from prepuberal mice in a simplified culture system. Hum Reprod 11,2656-2666.
Cortvrindt, R., Smitz, J., and VanSteirteghem, A.C. (1997). Assessment of the need for follicle stimulating hormone in early preantral mouse follicle culture in vitro. Hum Reprod 12,759-768.
Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., et al. (2001). The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Gene 27,159-166.
Cushman, R.A., Wahl, C.M., and Fortune, J.E. (2002). Bovine ovarian cortical pieces grafted to chick embryonic membranes:A model for studies on the activation of primordial follicles. Hum Reprod 17, 48-54.
Daniel, S.A.J., Armstrong, D.T., and Gorelangton, R.E. (1989). Growth and development of rat oocytes invitro. Gamete Res 24,109-121.
De Baere, E., Beysen, D., Oley, C., Lorenz, B., Cocquet, J., De Sutter, P., Devriendt, K., Dixon, M., Fellous, M., Fryns, J.P., et al. (2003). FOXL2 and BPES:Mutational hotspots, phenotypic variability, and revision of the genotype-phenotype correlation. Am J Hum Genet 72,478-487.
de Vet, A., Laven, J.S.E., de Jong, F.H., Themmen, A.P.N., and Fauser, B. (2002). Antimullerian hormone serum levels:a putative marker for ovarian aging. Fertil Steril 77,357-362.
Demeestere, I., Gervy, C., Centner, J., Devreker, F., Englert, Y., and Delbaere, A. (2004). Effect of insulin-like growth factor-I during preantral follicular culture on steroidogenesis, in vitro oocyte maturation, and embryo development in mice. Biol Reprod 70,1664-1669.
Denli, A.M., Tops, B.B., Plasterk, R.H., Ketting, R.F., and Hannon, G.J. (2004). Processing of primary microRNAs by the Microprocessor complex. Nature 432,231-235.
DePaola, N., Davies, P.F., Pritchard, W.F., Jr., Florez, L., Harbeck, N., and Polacek, D.C. (1999). Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro. Proc Natl Acad Sci U S A 96,3154-3159.
Devine, P.J., Rajapaksa, K.S., and Hoyer, P.B. (2002). In vitro ovarian tissue and organ culture:A review. Front Biosci 7, D1979-D1989.
Di Pasquale, E., Beck-Peccoz, P., and Persani, L. (2004). Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. Am J Hum Genet 75, 106-111.
Dierich, A., Sairam, M.R., Monaco, L., Fimia, GM., Gansmuller, A., LeMeur, M., and Sassone-Corsi, P. (1998). Impairing follicle-stimulating hormone (FSH) signaling in vivo:Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A 95, 13612-13617.
Dodson, W.C., and Schomberg, D.W. (1987). The effect of transforming growth-factor-beta on follicle-stimulating hormone-induced differentiation of cultured rat granulosa-cells. Endocrinology 120, 512-516.
Dong, J., Albertini, D.F., Nishimori, K., Kumar, T.R., Lu, N., and Matzuk, M.M. (1996). Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 383,531-535
Downs, S.M., Daniel, S.A.J., Bornslaeger, E.A., Hoppe, P.C., and Eppig, J.J. (1989). Maintenance of meiotic arrest in mouse oocytes by purines-modulation of camp levels and camp phosphodiesterase activity. Gamete Res 23,323-334.
Durlinger, A.L., Gruijters, M.J., Kramer, P., Karels, B., Ingraham, H.A., Nachtigal, M.W., Uilenbroek, J.T., Grootegoed, J.A., and Themmen, A.P. (2002). Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology 143,1076-1084.
Durlinger, A.L., Gruijters, M.J., Kramer, P., Karels, B., Kumar, T.R., Matzuk, M.M., Rose, U.M., de Jong, F.H., Uilenbroek, J.T., Grootegoed, J.A., et al. (2001). Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology 142,4891-4899.
Durlinger, A.L., Kramer, P., Karels, B., de Jong, F.H., Uilenbroek, J.T., Grootegoed, J.A., and Themmen, A.P. (1999). Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endocrinology 140,5789-5796.
Ebner, T., Sommergruber, M., Moser, M., Shebl, O., Schreier-Lechner, E., and Tews, G. (2006). Basal level of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles. Hum Reprod 21, 2022-2026.
Eppig, J.J. (1976). Analysis of mouse oogenesis invitro oocyte isolation and utilization of exogenous energy-sources by growing oocytes. J Exp Zool 198,375-381.
Eppig, J.J. (1991). Maintenance of meiotic arrest and the induction of oocyte maturation in mouse oocyte-granulosa cell complexes developed invitro from preantral follicles. Biol Reprod 45,824-830.
Eppig, J.J. (1994). Further reflections on culture systems for the growth of oocytes in-vitro. Hum Reprod 9, 974-976.
Eppig, J.J. (2001). Oocyte control of ovarian follicular development and function in mammals. Reproduction 122,829-838.
Eppig, J.J., and Downs, S.M. (1987). The effect of hypoxanthine on mouse oocyte growth and development invitro-maintenance of meiotic arrest and gonadotropin-induced oocyte maturation. Dev Biol 119, 313-321.
Eppig, J.J., and O'Brien, M.J. (1998). Comparison of preimplantation developmental competence after mouse oocyte growth and development in vitro and in vivo. Theriogenology 49,415-422.
Eppig, J.J., O'Brien, M.J., Pendola, F.L., and Watanabe, S. (1998). Factors affecting the developmental competence of mouse oocytes grown in vitro:Follicle-stimulating hormone and insulin. Biol Reprod 59, 1445-1453.
Eppig, J.J., Obrien, M., and Wigglesworth, K. (1996). Mammalian oocyte growth, and development in vitro. Mol Reprod Dev 44,260-273.
Eppig, J.J., and Obrien, M.J. (1996). Development in vitro of mouse oocytes from primordial follicles. Biol Reprod 54,197-207.
Eppig, J.J., and Schroeder, A.C. (1989). Capacity of mouse oocytes from preantral follicles to undergo embryogenesis and development to live young after growth, maturation, and fertilization invitro. Biol Reprod 41,268-276.
Eppig, J.J., Schroeder, A.C., Vandesandt, J.J.M., Ziomek, C.A., and Bavister, B.D. (1990). Developmental capacity of mouse oocytes that grow and mature in culture-the effect of modification of the protocol. Theriogenology 33,89-100.
Eppig, J.J., Wardbailey, P.F., and Coleman, D.L. (1985). Hypoxanthine and adenosine in murine ovarian follicular-fluid-concentrations and activity in maintaining oocyte meiotic arrest. Biol Reprod 33, 1041-1049.
Eppig, J.J., and Wigglesworth, K. (1995). Factors affecting the developmental competence of mouse oocytes grown in-vitro-oxygen concentration. Mol Reprod Dev 42,447-456.
Eppig, J.J., Wigglesworth, K., and Obrien, M.J. (1992). Comparison of embryonic developmental competence of mouse oocytes grown with and without serum. Mol Reprod Dev 32,33-40.
Eppig, J.J., Wigglesworth, K., and Pendola, F.L. (2002). The mammalian oocyte orchestrates the rate of ovarian follicular development. Proc Natl Acad Sci U S A 99,2890-2894.
Erickson, B.H. (1966). Development and senescence of the postnatal bovine ovary. J Anim Sci 25,800-805.
Erickson, G.F., and Shimasaki, S. (2003). The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Reprod Biol Endocrin:RB&E 1,9-9.
Farh, K.K., Grimson, A., Jan, C., Lewis, B.P., Johnston, W.K., Lim, L.P., Burge, C.B., and Bartel, D.P. (2005). The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science 310, 1817-1821.
Fernandez-Gonzalez, R., Moreira, P., Bilbao, A., Jimenez, A., Perez-Crespo, M., Ramirez, M.A., De Fonseca, F.R., Pintado, B., and Gutierrez-Adan, A. (2004). Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior. Proc Natl Acad Sci U SA101,5880-5885.
Figueiredo, J., Hulshof, S., Thiry, M., Van den Hurk, R., Bevers, M., Nusgens, B., and Beckers, J.-F. (1995). Extracellular matrix proteins and basement membrane:their identification in bovine ovaries and significance for the attachment of cultured preantral follicles. Theriogenology 43,845-858.
Figueiredo, J.R., Hulshof, S.C., Van den Hurk, R., Ectors, FJ., Fontes, R.S., Nusgens, B., Bevers, M.M., and Beckers, J.F. (1993). Development of a combined new mechanical and enzymatic method for the isolation of intact preantral follicles from fetal, calf and adult bovine ovaries. Theriogenology 40, 789-799.
Figueiredo, J.R., Hulshof, S.C.J., Vandenhurk, R., Nusgens, B., Bevers, M.M., Ectors, F.J., and Beckers, J.F. (1994). Preservation of oocyte and granulosa-cell morphology in bovine preantral follicles cultured in-vitro. Theriogenology 41,1333-1346.
Fire, A., Xu, S.Q., Montgomery, M.K., Kostas, S.A., Driver, S.E., and Mello, C.C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391,806-811.
Fletcher, C.E., Dart, D.A., Sita-Lumsden, A., Cheng, H., Rennie, P.S., and Bevan, C.L. (2012). Androgen-regulated processing of the oncomir MiR-27a, which targets Prohibitin in prostate cancer. Hum Mol Genet 21,3112-3127.
Fortune, J.E., Cushman, R.A., Wahl, C.M., and Kito, S. (2000). The primordial to primary follicle transition. Mol Cell Endocrinol 163,53-60.
Fortune, J.E., Kito, S., Wandji, S.A., and Srsen, V. (1998). Activation of bovine and baboon primordial follicles in vitro. Theriogenology 49,441-449.
Franchimont, P., Hazee-Hagelstein, M.T., Charlet-Renard, C., and Jaspar, J.M. (1986). Effect of mouse epidermal growth factor on DNA and protein synthesis, progesterone and inhibin production by bovine granulosa cells in culture. Acta Endocrinol (Copenh) 111,122-127.
Fulka, H., Mrazek, M., Tepla, O., and Fulka, J. (2004). DNA methylation pattern in human zygotes and developing embryos. Reproduction 128,703-708.
Gallardo, T.D., John, G.B., Bradshaw, K., Welt, C., Reijo-Pera, R., Vogt, P.H., Touraine, P., Bione, S., Toniolo, D., and Nelson, L.M. (2008). Sequence variation at the human FOXO3 locus:a study of premature ovarian failure and primary amenorrhea. Hum Reprod 23,216-221.
Galloway, S.M., McNatty, K.P., Cambridge, L.M., Laitinen, M.P.E., Juengel, J.L., Jokiranta, T.S., McLaren, R.J., Luiro, K., Dodds, K.G., Montgomery, G.W., et al. (2000). Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat Gene 25,279-283.
Gandolfi, F., Milanesi, E., Pocar, P., Luciano, A.M., Brevini, T.A.L., Acocella, F., Lauria, A., and Armstrong, D.T. (1998). Comparative analysis of calf and cow oocytes during in vitro maturation. Mol Reprod Dev 49,168-175.
Gigli, I., Byrd, D., and Fortune, J. (2006). Effects of oxygen tension and supplements to the culture medium on activation and development of bovine follicles in vitro. Theriogenology 66,344-353.
Gilchrist, R.B., Ritter, L.J., Myllymaa, S., Kaivo-Oja, N., Dragovic, R.A., Hickey, T.E., Ritvos, O., and Mottershead, D.G. (2006). Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation. J Cell Sci 119,3811-3821.
Gill, A., Jamnongjit, M., and Hammes, S.R. (2004). Androgens promote maturation and signaling in mouse oocytes independent of transcription:A release of inhibition model for mammalian oocyte meiosis. Mol Endocrinol 18,97-104.
Goldenberg, R.L., Powell, R.D., Rosen, S.W., Marshall, J.R., and Ross, GT. (1976). Ovarian morphology in women with anosmia and hypogonadotropic hypogonadism. Am J Obstet Gynecol 126,91-94.
Gook, D.A., Edgar, D.H., and Stern, C. (2004). Cryopreservation of human ovarian tissue. Eur J Obstet Gynecol Reprod Biol 113 Suppl 1, S41-44.
Gore-Langton, R.E., and Daniel, S.A. (1990). Follicle-stimulating hormone and estradiol regulate antrum-like reorganization of granulosa cells in rat preantral follicle cultures. Biol Reprod 43,65-72.
Gosden, R., and TELFER, E. (1987). Numbers of follicles and oocytes in mammalian ovaries and their allometric relationships. J Zool 211,169-175.
Gosden, R.G., and Byattsmith, J.G. (1986). Oxygen concentration gradient across the ovarian follicular epithelium-model, predictions and implications. Hum Reprod 1,65-68.
Gospodarowicz, D., Ill, C.R., and Birdwell, C.R. (1977). Effects of fibroblast and epidermal growth factors on ovarian cell proliferation in vitro. I. Characterization of the response of granulosa cells to FGF and EGF. Endocrinology 100,1108-1120.
Gougeon, A. (1996). Regulation of ovarian follicular development in primates:Facts and hypotheses. Endocr Rev 17,121-155.
Greenwald, GS., and Moor, R.M. (1989). Isolation and preliminary characterization of pig primordial follicles. J Reprod Fertil 87,561-571.
Gregory, R.I., Yan, K.P., Amuthan, G, Chendrimada, T., Doratotaj, B., Cooch, N., and Shiekhattar, R. (2004). The Microprocessor complex mediates the genesis of microRNAs. Nature 432,235-240.
Griffith, L.G, and Swartz, MA. (2006). Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7,211-224.
Grishok, A., Pasquinelli, A.E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D.L., Fire, A., Ruvkun, G, and Mello, C.C. (2001). Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans. Developmental Timing. Cell 106,23-34.
Guo, Q., Kumar, T.R., Woodruff, T., Hadsell, L.A., DeMayo, F.J., and Matzuk, M.M. (1998). Overexpression of mouse follistatin causes reproductive defects in transgenic mice. Mol Endocrinol 12,96-106.
Gutierrez, C.G, Ralph, J.H., Telfer, E.E., Wilmut, I., and Webb, R. (2000). Growth and antrum formation of bovine preantral follicles in long-term culture in vitro. Biol Reprod 62,1322-1328.
Hanrahan, J.P., Gregan, S.M., Mulsant, P., Mullen, M., Davis, GH., Powell, R., and Galloway, S.M. (2004). Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). Biol Reprod 70, 900-909.
Harada, M., Miyano, T., Matsumura, K., Osaki, S., Miyake, M., and Kato, S. (1997). Bovine oocytes from early antral follicles grow to meiotic competence in vitro:Effect of FSH and hypoxanthine. Theriogenology 48,743-755.
Harris, S.E., Adriaens, I., Leese, H.J., Gosden, R.G, and Picton, H.M. (2007). Carbohydrate metabolism by murine ovarian follicles and oocytes grown in vitro. Reproduction 134,415-424.
Harris, S.E., Leese, H.J., Gosden, R.G, and Picton, H.M. (2009). Pyruvate and Oxygen Consumption Throughout the Growth and Development of Murine Oocytes. Mol Reprod Dev 76,231-238.
Hartshorne, GM. (1997). In vitro culture of ovarian follicles. Rev Reprod 2,94-104.
Hartshorne, GM., Sargent, I.L., and Barlow, D.H. (1994). Meiotic progression of mouse oocytes throughout follicle growth and ovulation in-vitro. Hum Reprod 9,352-359.
Hashimoto, S., Ohsumi, K., Tsuji, Y, Harauma, N., Miyata, Y., Fukuda, A., Hosoi, Y., Iritani, A., and Morimoto, Y. (2007). Growing porcine oocyte-granulosa cell complexes acquired meiotic competence during in vitro culture. J Reprod Develop 53,379-384.
Haug, A., Larsen, B., and Smidsrod, O. (1967). Studies on sequence of uronic acid residues in alginic acid. Acta Chem Scand 21,691-&.
Hayashi, M., McGee, E.A., Min, G, Klein, C., Rose, U.M., van Duin, M., and Hsueh, A.J.W. (1999). Recombinant growth differentiation factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles. Endocrinology 140,1236-1244.
He, L., Thomson, J.M., Hemann, M.T., Hernando-Monge, E., Mu, D., Goodson, S., Powers, S., Cordon-Cardo, C., Lowe, S.W., Hannon, GJ., et al. (2005). A microRNA polycistron as a potential human oncogene. Nature 435,828-833.
Heise, M., Koepsel, R., Russell, A.J., and McGee, E.A. (2005). Calcium alginate microencapsulation of ovarian follicles impacts FSH delivery and follicle morphology. Reprod Biol Endocrinol 3,47.
Heise, M.K., Koepsel, R., McGee, E.A., and Russell, A.J. (2009). Dynamic oxygen enhances oocyte maturation in long-term follicle culture. Tissue Eng Part C Methods 15,323-332.
Hirao, Y, Itoh, T., Shimizu, M., Iga, K., Aoyagi, K., Kobayashi, M., Kacchi, M., Hoshi, H., and Takenouchi, N. (2004). In vitro growth and development of bovine oocyte-granulosa cell complexes on the flat substratum:Effects of high polyvinylpyrrolidone concentration in culture medium. Biol Reprod 70, 83-91.
Hirao, Y., and Miyano, T. (2008). In vitro growth of mouse oocytes:oocyte size at the beginning of culture influences the appropriate length of culture period. Journal of Mammalian Ova Research 25,56-62.
Hirao, Y, Nagai, T., Kubo, M., Miyano, T., Miyake, M., and Kato, S. (1994). In-vitro growth and maturation of pig oocytes. J Reprod Fertil 100,333-339.
Hirao, Y, Shimizu, M., Iga, K., and Takenouchi, N. (2009). Growth of Bovine Oocyte-Granulosa Cell Complexes Cultured Individually in Microdrops of Various Sizes. J Reprod Develop 55,88-93.
Hossain, M.M., Ghanem, N., Hoelker, M., Rings, F., Phatsara, C., Tholen, E., Schellander, K., and Tesfaye, D. (2009). Identification and characterization of miRNAs expressed in the bovine ovary. BMC Genomics 10,443.
Hovatta, O. (2004). Cryopreservation and culture of human ovarian cortical tissue containing early follicles. Eur J Obstet Gynecol Reprod Biol 113 Suppl 1, S50-54.
Hovatta, O., Silye, R., Abir, R., Krausz, T., and Winston, R. (1997). Extracellular matrix improves survival of both stored and fresh human primordial and primary ovarian follicles in long-term culture. Hum Reprod 12,1032-1036.
Hovatta, O., Wright, C., Krausz, T., Hardy, K., and Winston, R.M.L. (1999). Human primordial, primary and secondary ovarian follicles in long-term culture:effect of partial isolation. Hum Reprod 14,2519-2524.
Hrabia, A., Ha, Y, and Shimada, K. (2004). Expression of estrogen receptor mRNA in theca and granulosa layers of the ovary in relation to follicular growth in quail. Folia Biologica 52,3-4.
Hreinsson, J.G, Scott, J.E., Rasmussen, C., Swahn, M.L., Hsueh, A.J.W., and Hovatta, O. (2002). Growth differentiation factor-9 promotes the growth, development, and survival of human ovarian follicles in organ culture. J Clin Endocr Metab 87,316-321.
Hsueh, A., Dahl, K.D., Vaughan, J., Tucker, E., Rivier, J., Bardin, C.W., and Vale, W. (1987). Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc Natl Acad Sci U S A 84,5082-5086.
Hsueh, A.J., BILLIG, H., and Tsafriri, A. (1994). Ovarian follicle atresia:a hormonally controlled apoptotic process. Endocr Rev 15,707-724.
Hu, Y, Betzendahl, I., Cortvrindt, R., Smitz, J., and Eichenlaub-Ritter, U. (2001). Effects of low O(2) and ageing on spindles and chromosomes in mouse oocytes from pre-antral follicle culture. Hum Reprod 16, 737-748.
Hudson, P.L., Dougas, I., Donahoe, P.K., Cate, R.L., Epstein, J., Pepinsky, R.B., and Maclaughlin, D.T. (1990). An immunoassay to detect human mullerian inhibiting substance in males and females during normal development. J Clin Endocr Metab 70,16-22.
Hulshof, S.C.J., Figueiredo, J.R., Beckers, J.F., Bevers, M.M., Vanderdonk, J.A., and Vandenhurk, R. (1995). effects of fetal bovine serum, fsh and 17-beta-estradiol on the culture of bovine preantral follicles. Theriogenology 44,217-226.
Huntriss, J., Gosden, R., Hinkins, M., Oliver, B., Miller, D., Rutherford, A.J., and Picton, H.M. (2002). Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes. Molecular Hum Reprod 8,1087-1095.
Huntriss, J., and Picton, H.M. (2008). Epigenetic consequences of assisted reproduction and infertility on the human preimplantation embryo. Hum Fertil (Cambridge, England) 11,85-94.
Hutvagner, G, McLachlan, J., Pasquinelli, A.E., Balint, E., Tuschl, T., and Zamore, P.D. (2001). A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293,834-838.
Hutvagner, G, and Zamore, P.D. (2002). A microRNA in a multiple-turnover RNAi enzyme complex. Science 297,2056-2060.
Huynh, K., Jones, G., Thouas, G, Britt, K.L., Simpson, E.R., and Jones, M.E.E. (2004). Estrogen is not directly required for oocyte developmental competence. Biol Reprod 70,1263-1269.
Hwa, A.J., Fry, R.C., Sivaraman, A., So, P.T., Samson, L.D., Stolz, D.B., and Griffith, L.G (2007). Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes. FASEB J 21,2564-2579.
Hwang, H.W., and Mendell, J.T. (2007). MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 96 Suppl, R40-44.
Ikeda, Y.-h., Hirao, Y., and Miyano, T. (1999). Effects of androgens on early development of mouse follicles in organ-cultured ovaries. 日本哺乳动物卵子学会誌 16,148-153.
Imamura, T., Kerjean, A., Heams, T., Kupiec, J.J., Thenevin, C., and Paldi, A. (2005). Dynamic CpG and non-CpG methylation of the Pegl/Mest gene in the mouse oocyte and preimplantation embryo. J Biol Chem 280,20171-20175.
Iorio, M.V., Visone, R., Di Leva, G, Donati, V., Petrocca, F., Casalini, P., Taccioli, C., Volinia, S., Liu, C.-G., Alder, H., et al. (2007). MicroRNA signatures in human ovarian cancer. Cancer Res 67,8699-8707.
Ireland, J., Zielak-Steciwko, A., Jimenez-Krassel, F., Folger, J., Bettegowda, A., Scheetz, D., Walsh, S., Mossa, F., Knight, P., and Smith, G. (2009). Variation in the ovarian reserve is linked to alterations in intrafollicular estradiol production and ovarian biomarkers of follicular differentiation and oocyte quality in cattle. Biol Reprod 80,954-964.
Itoh, T., and Hoshi, H. (2000). Efficient isolation and long-term viability of bovine small preantral follicles in vitro. In Vitro Cell Dev Biol Anim 36,235-240.
Itoh, T., Kacchi, M., Abe, H., Sendai, Y., and Hoshi, H. (2002). Growth, antrum formation, and estradiol production of bovine preantral follicles cultured in a serum-free medium. Biol Reprod 67,1099-1105.
Jewgenow, K. (1996). Impact of peptide growth factors on the culture of small preantral follicles of domestic cats. Theriogenology 45,889-895.
Jewgenow, K. (1998). Role of media, protein and energy supplements on maintenance of morphology and DNA-synthesis of small preantral domestic cat follicles during short-term culture. Theriogenology 49, 1567-1577.
John, GB., Gallardo, T.D., Shirley, L.J., and Castrillon, D.H. (2008). Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth. Dev Biol 321,197-204.
Joyce, I.M., Clark, A.T., Pendola, F.L., and Eppig, J.J. (2000). Comparison of recombinant growth differentiation factor-9 and oocyte regulation of KIT ligand messenger ribonucleic acid expression in mouse ovarian follicles. Biol Reprod 63,1669-1675.
Joyce, I.M., Pendola, F.L., Wigglesworth, K., and Eppig, J.J. (1999). Oocyte regulation of kit ligand expression in mouse ovarian follicles. Dev Biol 214,342-353.
Juengel, J.L., Hudson, N.L., Berg, M., Hamel, K., Smith, P., Lawrence, S.B., Whiting, L., and McNatty, K.P. (2009). Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle. Reproduction 138,107-114.
Juengel, J.L., Hudson, N.L., Heath, D.A., Smith, P., Reader, K.L., Lawrence, S.B., O'Connell, A.R., Laitinen, M.P.E., Cranfield, M., Groome, N.P., et al. (2002). Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep. Biol Reprod 67, 1777-1789.
Juengel, J.L., and McNatty, K.P. (2005). The role of proteins of the transforming growth factor-beta superfamily in the intraovarian regulation of follicular development. Hum Reprod Update 11,143-160.
Juneja, S.C., Barr, K.J., Enders, G.C., and Kidder, G.M. (1999). Defects in the germ line and gonads of mice lacking connexin43. Biol Reprod 60,1263-1270.
Katska, L., Alm, H., and Rynska, B. (2000). Nuclear configuration of bovine oocytes derived from fresh and in vitro-cultured preantral and early antral ovarian follicles. Theriogenology 54,247-260.
Katska, L., and Rynska, B. (1998). The isolation and in vitro culture of bovine preantral and early antral follicles of different size classes. Theriogenology 50,213-222.
Kerjean, A., Couvert, P., Heams, T., Chalas, L., Poirier, K., Chelly, J., Jouannet, P., Paldi, A., and Poirot, C. (2003). In vitro follicular growth affects oocyte imprinting establishment in mice. Eur J Hum Genet 11, 493-496.
Ketting, R.F., Fischer, S.E., Bernstein, E., Sijen, T., Hannon, G.J., and Plasterk, R.H. (2001). Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev 15,2654-2659.
Kezele, P., Nilsson, E.E., and Skinner, M.K. (2005). Keratinocyte growth factor acts as a mesenchymal factor that promotes ovarian primordial to primary follicle transition. Biol Reprod 73,967-973.
Kezele, P.R., Nilsson, E.E., and Skinner, M.K. (2002). Insulin but not insulin-like growth factor-1 promotes the primordial to primary follicle transition. Mol Cell Endocrinol 192,37-43.
Khosla, S., Dean, W., Brown, D., Reik, W., and Feil, R. (2001). Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol Reprod 64,918-926.
Khvorova, A., Reynolds, A., and Jayasena, S.D. (2003). Functional siRNAs and miRNAs exhibit strand bias. Cell 115,209-216.
Knight, P.G., and Glister, C. (2006). TGF-beta superfamily members and ovarian follicle development. Reproduction 132,191-206.
Kotsuji, F., Kubo, M., and Tominaga, T. (1994). Effect of interactions between granulosa and thecal cells on meiotic arrest in bovine oocytes. J Reprod Fertil 100,151-156.
Kreeger, P.K., Deck, J.W., Woodruff, T.K., and Shea, L.D. (2006). The in vitro regulation of ovarian follicle development using alginate-extracellular matrix gels. Biomaterials 27,714-723.
Kreeger, P.K., Fernandes, N.N., Woodruff, T.K., and Shea, L.D. (2005). Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose. Biol Reprod 73,942-950.
Lane, M., and Gardner, D.K. (2003). Ammonium induces aberrant blastocyst differentiation, metabolism, pH regulation, gene expression and subsequently alters fetal development in the mouse. Biol Reprod 69, 1109-1117.
Lange, U.C., Saitou, M., Western, P.S., Barton, S.C., and Surani, M.A. (2003). The Fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice. BMC Dev Biol 3, (19 March 2003)-(2019 March 2003).
Lee, R.C., Feinbaum, R.L., and Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75,843-854.
Lee, W.S., Otsuka, F., Moore, R.K., and Shimasaki, S. (2001). Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat. Biol Reprod 65,994-999.
Lee, W.S., Yoon, S.J., Yoon, T.K., Cha, K.Y., Lee, S.H., Shimasaki, S., Lee, S., and Lee, K.A. (2004). Effects of bone morphogenetic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary. Mol Reprod Dev 69,159-163.
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Radmark, O., Kim, S., et al. (2003). The nuclear RNase III Drosha initiates microRNA processing. Nature 425,415-419.
Lee, Y., Jeon, K., Lee, J.T., Kim, S., and Kim, V.N. (2002a). MicroRNA maturation:stepwise processing and subcellular localization. EMBO J 21,4663-4670.
Lee, Y, Yu, X., Gonzales, F., Mangelsdorf, D.J., Wang, M.Y., Richardson, C., Witters, L.A., and Unger, R.H. (2002b). PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci U S A 99,11848-11853.
Leese, H.J., and Barton, A.M. (1984). Pyruvate and glucose-uptake by mouse ova and preimplantation embryos. J Reprod Fertil 72,9-13.
Lenie, S., and Smitz, J. (2009). Functional AR Signaling Is Evident in an In Vitro Mouse Follicle Culture Bioassay That Encompasses Most Stages of Folliculogenesis. Biol Reprod 80,685-695.
Lewis, B.P., Shih, I.H., Jones-Rhoades, M.W., Bartel, D.P., and Burge, C.B. (2003). Prediction of mammalian microRNA targets. Cell 115,787-798.
Li, Y, Yue, P., Deng, X., Ueda, T., Fukunaga, R., Khuri, F.R., and Sun, S.-Y. (2010). Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E. Neoplasia 12,848-855.
Liaw, D., Marsh, D.J., Li, J., Dahia, P.L.M., Wang, S.I., Zheng, Z.M., Bose, S., Call, K.M., Tsou, H.C., Peacocke, M., et al. (1997). Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Gene 16,64-67.
Liu, H.C., He, Z., and Rosenwaks, Z. (2001a). Application of complementary DNA microarray (DNA chip) technology in the study of gene expression profiles during folliculogenesis. Fertil Steril 75,947-955.
Liu, H.C., He, Z., and Rosenwaks, Z. (2002). In vitro culture and in vitro maturation of mouse preantral follicles with recombinant gonadotropins. Fertil Steril 77,373-383.
Liu, J., Van der Elst, J., Van den Broecke, R., and Dhont, M. (2001b). Live offspring by in vitro fertilization of oocytes from cryopreserved primordial mouse follicles after sequential in vivo transplantation and in vitro maturation. Biol Reprod 64,171-178.
Liu, X., Andoh, K., Abe, Y., Kobayashi, J., Yamada, K., Mizunuma, H., and Ibuki, Y. (1999). A comparative study on transforming growth factor-beta and activin A for preantral follicles from adult, immature, and diethylstilbestrol-primed immature mice. Endocrinology 140,2480-2485.
Liu, X., Andoh, K., Yokota, H., Kobayashi, J., Abe, Y., Yamada, K., Mizunuma, H., and Ibuki, Y. (1998). Effects of growth hormone, activin, and follistatin on the development of preantral follicle from immature female mice. Endocrinology 139,2342-2347.
Louhio, H., Hovatta, O., Sjoberg, J., and Tuuri, T. (2000). The effects of insulin, and insulin-like growth factors I and II on human ovarian follicles in long-term culture. Mol Hum Reprod 6,694-698.
Lubahn, D.B., Moyer, J.S., Golding, T.S., Couse, J.F., Korach, K.S., and Smithies, O. (1993). Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A 90,11162-11166.
Lucci, C.M., Rumpf, R., Figueiredo, J.R., and Bao, S.N. (2002). Zebu (Bos indicus) ovarian preantral follicles:morphological characterization and development of an efficient isolation method. Theriogenology 57,1467-1483.
Lund, E., Guttinger, S., Calado, A., Dahlberg, J.E., and Kutay, U. (2004). Nuclear export of microRNA precursors. Science 303,95-98.
Luque-Ramirez, M., San Millan, J.L., and Escobar-Morreale, H.F. (2006). Genomic variants in polycystic ovary syndrome. Clin Chim Acta 366,14-26.
Lussier, J.G., Matton, P., and Dufour, J.J. (1987). Growth rates of follicles in the ovary of the cow. J Reprod Fertil 81,301-307.
Ma, T., Jiang, H., Gao, Y, Zhao, Y, Dai, L., Xiong, Q., Xu, Y, Zhao, Z., and Zhang, J. (2011). Microarray analysis of differentially expressed microRNAs in non-regressed and regressed bovine corpus luteum tissue; microRNA-378 may suppress luteal cell apoptosis by targeting the interferon gamma receptor 1 gene. J Appl Genet 52,481-486.
Mao, J., Smith, M.F., Rucker, E.B., Wu, GM., McCauley, T.C., Cantley, T.C., Prather, R.S., Didion, BA., and Day, B.N. (2004). Effect of epidermal growth factor and insulin-like growth factor I on porcine preantral follicular growth, antrum formation, and stimulation of granulosal cell proliferation and suppression of apoptosis in vitro. J Anim Sci 82,1967-1975.
Matzuk, M.M., Burns, K.H., Viveiros, M.M., and Eppig, J.J. (2002). Intercellular communication in the mammalian ovary:Oocytes carry the conversation. Science 296,2178-2180.
Matzuk, M.M., Kumar, T.R., and Bradley, A. (1995). Different phenotypes for mice deficient in either activins or activin receptor-type-II. Nature 374,356-360.
May, J.V., Frost, J.P., and Schomberg, D.W. (1988). Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. Endocrinology 123,168-179.
McCaffery, F.H., Leask, R., Riley, S.C., and Telfer, E.E. (2000). Culture of bovine preantral follicles in a serum-free system:Markers for assessment of growth and development. Biol Reprod 63,267-273.
McGee, E., Spears, N., Minami, S., Hsu, S.Y., Chun, S.Y., Billig, H., and Hsueh, A.J.W. (1997). Preantral ovarian follicles in serum-free culture:Suppression of apoptosis after activation of the cyclic guanosine 3',5'-monophosphate pathway and stimulation of growth and differentiation by follicle-stimulating hormone. Endocrinology 138,2417-2424.
McGee, E.A., and Hsueh, AJ.W. (2000). Initial and cyclic recruitment of ovarian follicles. Endocr Rev 21, 200-214.
McLaughlin, M., and Telfer, E.E. (2010). Oocyte development in bovine primordial follicles is promoted by activin and FSH within a two-step serum-free culture system. Reproduction 139,971-978.
McNatty, K.P., Smith, P., Hudson, N.L., Heath, D.A., Tisdall, D.J., O, W.S., and Braw-Tal, R. (1995). Development of the sheep ovary during fetal and early neonatal life and the effect of fecundity genes. J Reprod Fertil Suppl 49,123-135.
Mitchell, L.M., Kennedy, C.R., and Hartshorne, G.M. (2002). Effects of varying gonadotrophin dose and timing on antrum formation and ovulation efficiency of mouse follicles in vitro. Hum Reprod 17, 1181-1188.
Mizunuma, H., Liu, X.W., Andoh, K., Abe, Y., Kobayashi, J., Yamada, K., Yokota, H., Ibuki, Y, and Hasegawa, Y. (1999). Activin from secondary follicles causes small preantral follicles to remain dormant at the resting stage. Endocrinology 140,37-42.
Monget, P., Fabre, S., Mulsant, P., Lecerf, F., Elsen, J.M., Mazerbourg, S., Pisselet, C., and Monniaux, D. (2002). Regulation of ovarian folliculogenesis by IGF and BMP system in domestic animals. Domest Anim Endocrinol 23,139-154.
Morimoto, Y., Oku, Y, Sonoda, M., Haruk, A., Ito, K., Hashimoto, S., and Fukuda, A. (2007). High oxygen atmosphere improves human follicle development in organ cultures of ovarian cortical tissues in vitro. Hum Reprod 22,3170-3177.
Morison, I.M., Ramsay, J.P., and Spencer, H.G (2005). A census of mammalian imprinting. Trends Genet 21, 457-465.
Moritake, S., Hirao, Y, and Miyano, T. (2002). Hypoxanthine promotes the acquisition of meiotic competence in pig oocytes from early antral follicles during growth culture.日本哺乳勤物卵子学会誌19,3945.
Moss, E.G., Lee, R.C., and Ambros, V. (1997). The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell 88,637-646.
Mousset-Simeon, N., Jouannet, P., Le Cointre, L., Coussieu, C., and Poirot, C. (2005). Comparison of three in vitro culture systems for maturation of early preantral mouse ovarian follicles. Zygote 13,167-175.
Murchison, E.P., Stein, P., Xuan, Z., Pan, H., Zhang, M.Q., Schultz, R.M., and Hannon, GJ. (2007). Critical roles for Dicer in the female germline. Genes Dev 21,682-693.
Murray, A.A., Gosden, R.G, Allison, V., and Spears, N. (1998). Effect of androgens on the development of mouse follicles growing in vitro. J Reprod Fertil 113,27-33.
Murray, A.A., Swales, A.K.E., Smith, R.E., Molinek, M.D., Hillier, S.G, and Spears, N. (2008). Follicular growth and oocyte competence in the in vitro cultured mouse follicle:effects of gonadotrophins and steroids. Molecular Hum Reprod 14,75-83.
Muruvi, W., Picton, H.M., Rodway, R.G, and Joyce, I.M. (2005). In vitro growth of oocytes from primordial follicles isolated from frozen-thawed lamb ovaries. Theriogenology 64,1357-1370.
Muruvi, W., Picton, H.M., Rodway, R.G, and Joyce, I.M. (2009). In vitro growth and differentiation of primary follicles isolated from cryopreserved sheep ovarian tissue. Anim Reprod Sci 112,36-50.
Muttukrishna, S., Tannetta, D., Groome, N., and Sargent, I. (2004). Activin and follistatin in female reproduction. Mol Cell Endocrinol 225,45-56.
Nation, A., and Selwood, L. (2009). The production of mature oocytes from adult ovaries following primary follicle culture in a marsupial. Reproduction 138,247-255.
Nayudu, P.L., Fehrenbach, A., Kiesel, P., Vitt, U.A., Pancharatna, K., and Osborn, S. (2001). Progress toward understanding follicle development in vitro:Appearances are not deceiving. Arch Med Res 32,587-594.
Nayudu, P.L., and Osborn, S.M. (1992). Factors influencing the rate of preantral and antral growth of mouse ovarian follicles invitro. J Reprod Fertil 95,349-362.
Neufeld, G, Ferrara, N., Schweigerer, L., Mitchell, R., and Gospodarowicz, D. (1987). Bovine granulosa cells produce basic fibroblast growth factor. Endocrinology 121,597-603.
Newton, H., and Illingworth, P. (2001). In-vitro growth of murine pre-antral follicles after isolation from cryopreserved ovarian tissue. Hum Reprod 16,423-429.
Newton, H., Picton, H., and Gosden, R.G (1999). In vitro growth of oocyte-granulosa cell complexes isolated from cryopreserved ovine tissue. J Reprod Fertil 115,141-150.
Nilsson, E.E., Kezele, P., and Skinner, M.K. (2002). Leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transition in rat ovaries. Mol Cell Endocrinol 188,65-73.
Nilsson, E.E., and Skinner, M.K. (2002). Growth and differentiation factor-9 stimulates progression of early primary but not primordial rat ovarian follicle development. Biol Reprod 67,1018-1024.
Nilsson, E.E., and Skinner, M.K. (2003). Bone morphogenetic protein-4 acts as an ovarian follicle survival factor and promotes primordial follicle development. Biol Reprod 69,1265-1272.
Nilsson, E.E., and Skinner, M.K. (2004). Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transition. Mol Cell Endocrinol 214,19-25.
Nogueira, D., Cortvrindt, R., Everaerdt, B., and Smitz, J. (2005). Effects of long-term in vitro exposure to phosphodiesterase type-3 inhibitors on follicle and oocyte development. Reproduction 130,177-186.
Nonowaki, S., Takahashi, K., and Horiuchi, T. (2010). Culture media affect follicle survival and oocyte maturation in preantral mouse follicle cultures. Journal of Mammalian Ova Research 27,35-41.
Nuttinck, F., Mermillod, P., Massip, A., and Dessy, F. (1993). Characterization of invitro growth of bovine preantral ovarian follicles-a preliminary-study. Theriogenology 39,811-821.
O'Brien, M.J., Pendola, J.K., and Eppig, J.J. (2003). A revised protocol for in vitro development of mouse oocytes from primordial follicles dramatically improves their developmental competence. Biol Reprod 68,1682-1686.
O'Donnell, K.A., Wentzel, E.A., Zeller, K.I., Dang, C.V., and Mendell, J.T. (2005). c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435,839-843.
Obata, Y., Kono, T., and Hatada, I. (2002). Oogenesis:Maturation of mouse fetal germ cells in vitro-Even immature oocytes can eventually be fertilized after some skilful manipulation. Nature 418,497-498.
Ohinata, Y., Ohta, H., Shigeta, M., Yamanaka, K., Wakayama, T., and Saitou, M. (2009). A signaling principle for the specification of the germ cell lineage in mice. Cell 137,571-584.
Oktay, K., Briggs, D., and Gosden, R.G (1997). Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles. J Clin Endocr Metab 82,3748-3751.
Oktay, K., Karlikaya, G., Akman, O., Ojakian, GK., and Oktay, M. (2000). Interaction of extracellular matrix and activin-A in the initiation of follicle growth in the mouse ovary. Biol Reprod 63,457-461.
Oktay, K., Newton, H., Mullan, J., and Gosden, R.G (1998). Development of human primordial follicles to antral stages in scid/hpg mice stimulated with follicle stimulating hormone. Hum Reprod 13,1133-1138.
Oktem, O., and Oktay, K. (2007). The role of extracellular matrix and activin-A in in vitro growth and survival of murine preantral follicles. Reprod Sci 14,358-366.
Otsuka, F., Moore, R.K., Iemura, S., Ueno, N., and Shimasaki, S. (2001). Follistatin inhibits the function of the oocyte-derived factor BMP-15. Biochem Biophys Res Commun 289,961-966.
Otsuka, F., Yao, Z.X., Lee, T.H., Yamamoto, S., Erickson, G.F., and Shimasaki, S. (2000). Bone morphogenetic protein-15-Identification of target cells and biological functions. J Biol Chem 275, 39523-39528.
Palter, S.F., Tavares, A.B., Hourvitz, A., Veldhuis, J.D., and Adashi, E.Y. (2001). Are estrogens of import to primate/human ovarian folliculogenesis? Endocr Rev 22,389-424.
Pangas, S.A., Saudye, H., Shea, L.D., and Woodruff, T.K. (2003). Novel approach for the three-dimensional culture of granulosa cell-oocyte complexes. Tissue Eng 9,1013-1021.
Park, S.M., Shell, S., Radjabi, A.R., Schickel, R., Feig, C., Boyerinas, B., Dinulescu, D.M., Lengyel, E., and Peter, M.E. (2007). Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle 6,2585-2590.
Pasquinelli, A.E., Reinhart, B.J., Slack, F., Martindale, M.Q., Kuroda, M.I., Maller, B., Hayward, D.C., Ball, E.E., Degnan, B., Muller, P., et al. (2000). Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408,86-89.
Pesty, A., Miyara, F., Debey, P., Lefevre, B., and Poirot, C. (2007). Multiparameter assessment of mouse oogenesis during follicular growth in vitro. Molecular Hum Reprod 13,3-9.
Picton, H.M., Danfour, M.A., Harris, S.E., Chambers, E.L., and Huntriss, J. (2003). Growth and maturation of oocytes in vitro. Reproduction (Cambridge, England) Supplement 61,445-462.
Picton, H.M., Harris, S.E., Muruvi, W., and Chambers, E.L. (2008). The in vitro growth and maturation of follicles. Reproduction 136,703-715.
Picton, H.M., Mkandla, A., Salha, O., Wynn, P., and Gosden, R.G. (1999). Initiation of human primordial follicle growth in vitro in ultrathin slices of ovarian cortex. Hum Reprod 14,11-11.
Qureshi, A.I., Nussey, S.S., Bano, G, Musonda, P., Whitehead, S.A., and Mason, H.D. (2008). Testosterone selectively increases primary follicles in ovarian cortex grafted onto embryonic chick membranes: relevance to polycystic ovaries. Reproduction 136,187-194.
Rajkovic, A. (2007). Genetics of ovarian failure and development. Semin Reprod Med 25,223-224.
Rajkovic, A., Pangas, S.A., Ballow, D., Suzumori, N., and Matzuk, M.M. (2004). NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science 305,1157-1159.
Rajpert-De Meyts, E., Jorgensen, N., Graem, N., Muller, J., Cate, R.L., and Skakkebaek, N.E. (1999). Expression of anti-Mullerian hormone during normal and pathological gonadal development: Association with differentiation of Sertoli and granulosa cells. J Clin Endocr Metab 84,3836-3844.
Rankin, T., Familari, M., Lee, E., Ginsberg, A., Dwyer, N., BlanchetteMackie, J., Drago, J., Westphal, H., and Dean, J. (1996). Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development 122,2903-2910.
Redding, G.P., Bronlund, J.E., and Hart, A.L. (2007). Mathematical modelling of oxygen transport-limited follicle growth. Reproduction 133,1095-1106.
Reddy, P., Liu, L., Adhikari, D., Jagarlamudi, K., Rajareddy, S., Shen, Y., Du, C., Tang, W., Hamalainen, T., Peng, S.L., et al. (2008). Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science 319,611-613.
Reinhart, B.J., Slack, F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E., Horvitz, H.R., and Ruvkun, G (2000). The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403,901-906.
Reinhart, B.J., Weinstein, E.G., Rhoades, M.W., Bartel, B., and Bartel, D.P. (2002). MicroRNAs in plants. Genes Dev 16,1616-1626.
Rhoades, M.W., Reinhart, B.J., Lim, L.P., Burge, C.B., Bartel, B., and Bartel, D.P. (2002). Prediction of plant microRNA targets. Cell 110,513-520.
Rice, S., Ojha, K., and Mason, H. (2008). Human ovarian biopsies as a viable source of pre-antral follicles. Hum Reprod 23,600-605.
Richard, F.J., and Sirard, M.A. (1996). Effects of follicular cells on oocyte maturation.2. Theca cell inhibition of bovine oocyte maturation in vitro. Biol Reprod 54,22-28.
Richards, J.S. (1980). Maturation of ovarian follicles:actions and interactions of pituitary and ovarian hormones on follicular cell differentiation. Physiol Rev 60,51-89.
Richards, J.S., Jonassen, J.A., Rolfes, A.I., Kersey, K., and Reichert, L.E. (1979). Adenosine 3', 5'-monophosphate, luteinizing hormone receptor, and progesterone during granulosa cell differentiation: effects of estradiol and follicle-stimulating hormone. Endocrinology 104,765-773.
Rico, C., Fabre, S., Medigue, C., Di Clemente, N., Clement, F., Bontoux, M., Touze, J.-L., Dupont, M., Briant, E., and Remy, B. (2009). Anti-mtlllerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow. Biol Reprod 80,50-59.
Roberts, R., Franks, S., and Hardy, K. (2002). Culture environment modulates maturation and metabolism of human oocytes. Hum Reprod 17,2950-2956.
Robker, R.L., and Richards, J.S. (1998). Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1. Mol Endocrinol 12,924-940.
Rodriguez, A., Griffiths-Jones, S., Ashurst, J.L., and Bradley, A. (2004). Identification of mammalian microRNA host genes and transcription units. Genome Res 14,1902-1910.
Rose, U.M., Hanssen, R., and Kloosterboer, H.J. (1999). Development and characterization of an in vitro ovulation model using mouse ovarian follicles. Biol Reprod 61,503-511.
Rosenfeld, N., Aharonov, R., Meiri, E., Rosenwald, S., Spector, Y, Zepeniuk, M., Benjamin, H., Shabes, N., Tabak, S., Levy, A., et al. (2008). MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol 26,462-469.
Rowghani, N.M., Heise, M.K., McKeel, D., McGee, E.A., Koepsel, R.R., and Russell, A.J. (2004). Maintenance of morphology and growth of ovarian follicles in suspension culture. Tissue Eng 10, 545-552.
Roy, S.K., and Kole, A.R. (1998). Ovarian transforming growth factor-beta (TGF-beta) receptors:in-vitro effects of follicle stimulating hormone, epidermal growth factor and TGF-beta on receptor expression in human preantral follicles. Molecular Hum Reprod 4,207-214.
Roy, S.K., and Treacy, B.J. (1993). Isolation and long-term culture of human preantral follicles. Fertil Steril 59,783-790.
Sadatsuki, M., Tsutsumi, O., Yamada, R., Muramatsu, M., and Taketani, Y. (1993). Local regulatory effects of activin-a and follistatin on meiotic maturation of rat oocytes. Biochem Biophys Res Commun 196, 388-395.
Sagirkaya, H., Misirlioglu, M., Kaya, A., First, N.L., Parrish, J.J., and Memili, E. (2007). Developmental potential of bovine oocytes cultured in different maturation and culture conditions. Anim Reprod Sci 101,225-240.
Saha, S., Shimizu, M., Geshi, M., and Izaike, Y. (2000a). In vitro culture of bovine preantral follicles. Anim Reprod Sci 63,27-39.
Saha, S., Shimizu, M., Geshi, M., and Izaike, Y. (2000b). In vitro culture of bovine preantral follicles. Anim Reprod Sci 63,27-39.
Saha, S., Shimizu, M., Geshi, M., and Izaike, Y. (2002). Comparison of enzymatic and mechanical methods for the collection of bovine preantral follicles. J Anim Sci 74,155-161.
Saha, S., Shimizu, M., and Izaike, Y (1999). In vitro culture and characterization of bovine preantral follicles (PAF). Theriogenology 51,308.
Saitou, M., Barton, S.C., and Surani, M.A. (2002). A molecular programme for the specification of germ cell fate in mice. Nature 418,293-300.
Santos, M.A., Kuijk, E.W., and Macklon, N.S. (2010). The impact of ovarian stimulation for IVF on the developing embryo. Reproduction 139,23-34.
Saragueta, P.E., Lanuza, G.M., and Baranao, J.L. (2002). Autocrine role of transforming growth factor beta 1 on rat granulosa cell proliferation. Biol Reprod 66,1862-1868.
SASSON, R., DANTES, A., TAJIMA, K., and AMSTERDAM, A. (2003). Novel genes modulated by FSH in normal and immortalized FSH-responsive cells:new insights into the mechanism of FSH action. FASEB J 17,1256-1266.
Schier, A.F. (2007). The maternal-zygotic transition:death and birth of RNAs. Science 316,406-407.
Schwarz, D.S., Hutvagner, G., Du, T., Xu, Z., Aronin, N., and Zamore, P.D. (2003). Asymmetry in the assembly of the RNAi enzyme complex. Cell 115,199-208.
Scott, J.E., Zhang, P., and Hovatta, O. (2004). Benefits of 8-bromo-guanosine 3',5'-cyclic monophosphate (8-br-cGMP) in human ovarian cortical tissue culture. Reprod Biomed Online 8,319-324.
Sen, A., and Hammes, S.R. (2010). Granulosa Cell-Specific Androgen Receptors Are Critical Regulators of Ovarian Development and Function. Mol Endocrinol 24,1393-1403.
Senbon, S., and Miyano, T. (2002). Bovine oocytes in early antral follicles grow in serum-free media:effect of hypoxanthine on follicular morphology and oocyte growth. Zygote 10,301-309.
Shaywitz, A.J., and Greenberg, M.E. (1999). CREB:a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68,821-861.
Shimasaki, S., Moore, R.K., Otsuka, F., and Erickson, GF. (2004). The bone morphogenetic protein system in mammalian reproduction. Endocr Rev 25,72-101.
Shimasaki, S., Zachow, R.J., Li, D.M., Kim, H., Iemura, S., Ueno, N., Sampath, K., Chang, R.J., and Erickson, GF. (1999). A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci USA96,7282-7287.
Shuttleworth, G, Pipkin, F.B., and Hunter, M.G (2002). In vitro development of pig preantral follicles cultured in a serum-free medium and the effect of angiotensin II. Reproduction 123,807-818.
Silva, C.C., Groome, N.P., and Knight, P.G. (1999). Demonstration of a suppressive effect of inhibin alpha-subunit on the developmental competence of in vitro matured bovine oocytes. J Reprod Fertil 115,381-388.
Simon, A.M., Goodenough, D.A., Li, E., and Paul, D.L. (1997). Female infertility in mice lacking connexin 37. Nature 385,525-529.
Sirotkin, A.V., Laukova, M., Ovcharenko, D., Brenaut, P., and MLyncek, M. (2010). Identification of microRNAs controlling human ovarian cell proliferation and apoptosis. J Cell Physiol 223,49-56.
Sirotkin, A.V., Ovcharenko, D., Grossmann, R., Laukova, M., and MLyntek, M. (2009). Identification of MicroRNAs Controlling Human Ovarian Cell Steroidogenesis Via a Genome-Scale Screen. J Cell Physiol 219,415-420.
Skinner, M.K. (2005). Regulation of primordial follicle assembly and development. Hum Reprod Update 11, 461-471.
Smitz, J., and Cortvrindt, R. (1998). Follicle culture after ovarian cryostorage. Maturitas 30,171-179.
Smitz, J., Cortvrindt, R., Hu, Y.X., and Vanderstichele, H. (1998). Effects of recombinant activin A on in vitro culture of mouse preantral follicles. Mol Reprod Dev 50,294-304.
Smitz, J., Cortvrindt, R., and vanSteirteghem, A.C. (1996). Normal oxygen atmosphere is essential for the solitary long-term culture of early preantral mouse follicles. Mol Reprod Dev 45,466-475.
Smitz, J., Dolmans, M.M., Donnez, J., Fortune, J.E., Hovatta, O., Jewgenow, K., Picton, H.M., Plancha, C., Shea, L.D., Stouffer, R.L., et al. (2010). Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation:implications for fertility preservation. Hum Reprod Update 16,395-414.
Solloway, M.J., Dudley, A.T., Bikoff, E.K., Lyons, K.M., Hogan, B.L.M., and Robertson, E.J. (1998). Mice lacking Bmp6 function. Dev Genet 22,321-339.
Spears, N., Boland, N.I., Murray, A.A., and Gosden, R.G. (1994). Mouse oocytes derived from in-vitro grown primary ovarian follicles are fertile. Hum Reprod 9,527-532.
Spears, N., Murray, A.A., Allison, V., Boland, N.I., and Gosden, R.G. (1998). Role of gonadotrophins and ovarian steroids in the development of mouse follicles in vitro. J Reprod Fertil 113,19-26.
Spicer, L.J., Aad, P.Y., Allen, D.T., Mazerbourg, S., Payne, A.H., and Hsueh, A.J. (2008). Growth differentiation factor 9 (GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells:influence of follicle size on responses to GDF9. Biol Reprod 78,243-253.
Stitzel, M.L., and Seydoux, G. (2007). Regulation of the oocyte-to-zygote transition. Science 316,407-408.
Su, Y.Q., Sugiura, K., Woo, Y., Wigglesworth, K., Kamdar, S., Affourtit, J., and Eppig, J.J. (2007). Selective degradation of transcripts during meiotic maturation of mouse oocytes. Dev Biol 302,104-117.
Tang, F., Kaneda, M., O'Carroll, D., Hajkova, P., Barton, S.C., Sun, YA., Lee, C., Tarakhovsky, A., Lao, K., and Surani, M.A. (2007). Maternal microRNAs are essential for mouse zygotic development. Genes Dev 21,644-648.
Taylor, D.D., and Gercel-Taylor, C. (2008). MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 110,13-21.
Telfer, E., Webb, R., Moor, R., and Gosden, R. (1999). New approaches to increasing oocyte yield from ruminants. J Anim Sci 68.
Telfer, E.E. (1996). The development of methods for isolation and culture of preantral follicles from bovine and porcine ovaries. Theriogenology 45,101-110.
Telfer, E.E., Binnie, J.P., McCaffery, F.H., and Campbell, B.K. (2000). In vitro development of oocytes from porcine and bovine primary follicles. Mol Cell Endocrinol 163,117-123.
Telfer, E.E., McLaughlin, M., Ding, C., and Thong, K.J. (2008). A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin. Hum Reprod 23,1151-1158.
Thomas, F.H., Campbell, B.K., Armstrong, D.G, and Telfer, E.E. (2007). Effects of IGF-I bioavailability on bovine preantral follicular development in vitro. Reproduction 133,1121-1128.
Thomas, F.H., Ismail, R.S., Jiang, J.-Y., and Vanderhyden, B.C. (2008). Kit ligand 2 promotes murine oocyte growth in vitro. Biol Reprod 78,167-175.
Thomas, F.H., Leask, R., Srsen, V., Riley, S.C., Spears, N., and Telfer, E.E. (2001). Effect of ascorbic acid on health and morphology of bovine preantral follicles during long-term culture. Reproduction 122, 487-495.
Tilly, J.L., and Tilly, K.I. (1995). Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles. Endocrinology 136,242-252.
Tomic, D., Miller, K.P., Kenny, H.A., Woodruff, T.K., Hoyer, P., and Flaws, J.A. (2004). Ovarian follicle development requires Smad3. Mol Endocrinol 18,2224-2240.
Tonetta, S.A., and diZerega, G.S. (1989). Intragonadal regulation of follicular maturation. Endocr Rev 10, 205-229.
Van den Hurk, R., Bevers, M., and Beckers, J.-F. (1997). In-vivo and in-vitro development of preantral follicles. Theriogenology 47,73-82.
van Rooij, I.A.J., Broekmans, F.J.M., te Velde, E.R., Fauser, B., Bancsi, L., de Jong, F.H., and Themmen, A.P.N. (2002). Serum anti-Mullerian hormone levels:a novel measure of ovarian reserve. Hum Reprod 17,3065-3071.
van Wagtendonk-de Leeuw, A.M., Mullaart, E., de Roos, A.P.W., Merton, J.S., den Daas, J.H.G., Kemp, B., and de Ruigh, L. (2000). Effects of different reproduction techniques:AI, MOET or IVP, on health and welfare of bovine offspring. Theriogenology 53,575-597.
Vanderhyden, B., Cohen, J., and Morley, P. (1993). Mouse oocytes regulate granulosa cell steroidogenesis. Endocrinology 133,423-426.
Vanderhyden, B.C., and Macdonald, E.A. (1998). Mouse oocytes regulate granulosa cell steroidogenesis throughout follicular development. Biol Reprod 59,1296-1301.
Vassena, R., Schramm, R.D., and Latham, K.E. (2005). Species-dependent expression patterns of DNA methyltransferase genes in mammalian oocytes and preimplantation embryos. Mol Reprod Dev 72, 430-436.
Visser, J.A., de Jong, F.H., Laven, J.S., and Themmen, A.P. (2006). Anti-Mullerian hormone:a new marker for ovarian function. Reproduction 131,1-9.
Visser, J.A., and Themmen, A.P.N. (2005). Anti-Mullerian hormone and folliculogenesis. Mol Cell Endocrinol 234,81-86.
Vitt, U.A., Hayashi, M., Klein, C., and Hsueh, A.J.W. (2000a). Growth differentiation factor-9 stimulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulosa cells from small antral and preovulatory rat follicles. Biol Reprod 62,370-377.
Vitt, U.A., McGee, E.A., Hayashi, M., and Hsueh, A.J.W. (2000b). In vivo treatment with GDF-9 stimulates primordial and primary follicle progression and theca cell marker CYP17 in ovaries of immature rats. Endocrinology 141,3814-3820.
W-S, O., Robertson, D., and De Kretser, D. (1989). Inhibin as an oocyte meiotic inhibitor. Mol Cell Endocrinol 62,307-311.
Walters, K.A., Allan, C.M., and Handelsman, D.J. (2008). Androgen actions and the ovary. Biol Reprod 78, 380-389.
Walters, K.A., Binnie, J.P., Campbell, B.K., Armstrong, D.G, and Telfer, E.E. (2006). The effects of IGF-I on bovine follicle development and IGFBP-2 expression are dose and stage dependent. Reproduction 131, 515-523.
Wandji, S.A., Srsen, V., Nathanielsz, P.W., Eppig, J.J., and Fortune, J.E. (1997). Initiation of growth of baboon primordial follicles in vitro. Hum Reprod 12,1993-2001.
Wandji, S.A., Srsen, V., Voss, A.K., Eppig, J.J., and Fortune, J.E. (1996). Initiation in vitro of growth of bovine primordial follicles. Biol Reprod 55,942-948.
Wang, J.R., and Roy, S.K. (2004). Growth differentiation factor-9 and stem cell factor promote primordial follicle formation in the hamster:Modulation by follicle-stimulating hormone. Biol Reprod 70,577-585.
Wassarman, P.M., Josefowicz, W.J., and Letourneau, GE. (1976). Meiotic maturation of mouse oocytes invitro-inhibition of maturation at specific stages of nuclear progression. J Cell Sci 22,531-545.
Watanabe, T., Takeda, A., Tsukiyama, T., Mise, K., Okuno, T., Sasaki, H., Minami, N., and Imai, H. (2006). Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev 20, 1732-1743.
Weaver, V.M., Fischer, A.H., Peterson, O.W., and Bissell, M.J. (1996). The importance of the microenvironment in breast cancer progression:recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochem Cell Biol 74,833-851.
Webber, L.J., Stubbs, S.A., Stark, J., Margara, R.A., Trew, GH., Lavery, S.A., Hardy, K., and Franks, S. (2007). Prolonged survival in culture of preantral follicles from polycystic ovaries. J Clin Endocr Metab 92,1975-1978.
Weenen, C, Laven, J.S.E., von Bergh, A.R.M., Cranfield, M., Groome, N.P., Visser, J.A., Kramer, P., Fauser, B., and Themmen, A.P.N. (2004). Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Molecular Hum Reprod 10,77-83.
West, E.R., Xu, M., Woodruff, T.K., and Shea, L.D. (2007). Physical properties of alginate hydrogels and their effects on in vitro follicle development. Biomaterials 28,4439-4448.
Wightman, B., Ha, I., and Ruvkun, G. (1993). Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75,855-862.
Williams, A.H., Liu, N., van Rooij, E., and Olson, E.N. (2009). MicroRNA control of muscle development and disease. Curr Opin Cell Biol 21,461-469.
Wood, J.R., Dumesic, D.A., Abbott, D.H., and Strauss, J.F.,3rd (2007). Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab 92,705-713.
Wright, C.S., Hovatta, O., Margara, R., Trew, G, Winston, R.M.L., Franks, S., and Hardy, K. (1999). Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles. Hum Reprod 14,1555-1562.
Wu, J., Emery, B.R., and Carrell, D.T. (2001). In vitro growth, maturation, fertilization, and embryonic development of oocytes from porcine preantral follicles. Biol Reprod 64,375-381.
Wycherley, G, Downey, D., Kane, M.T., and Hynes, A.C. (2004). A novel follicle culture system markedly increases follicle volume, cell number and oestradiol secretion. Reproduction 127,669-677.
Xiao, S., Robertson, D.M., and Findlay, J.K. (1992). Effects of activin and follicle-stimulating-hormone (fsh)-suppressing protein follistatin on fsh receptors and differentiation of cultured rat granulosa-cells. Endocrinology 131,1009-1016.
Xu, M., West, E., Shea, L.D., and Woodruff, T.K. (2006). Identification of a stage-specific permissive in vitro culture environment for follicle growth and oocyte development. Biol Reprod 75,916-923.
Xu, S., Linher-Melville, K., Yang, B.B., Wu, D., and Li, J. (2011). Micro-RNA378 (miR-378) regulates ovarian estradiol production by targeting aromatase. Endocrinology 152,3941-3951.
Yamoto, M., Minami, S., Nakano, R., and Kobayashi, M. (1992). Immunohistochemical localization of inhibin activin subunits in human ovarian follicles during the menstrual-cycle. J Clin Endocr Metab 74, 989-993.
Yan, C.N., Wang, P., DeMayo, J., DeMayo, F.J., Elvin, J.A., Carino, C., Prasad, S.V., Skinner, S.S., Dunbar, B.S., Dube, J.L., et al. (2001). Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol 15,854-866.
Yan, W., Morozumi, K., Zhang, J., Ro, S., Park, C., and Yanagimachi, R. (2008). Birth of mice after intracytoplasmic injection of single purified sperm nuclei and detection of messenger RNAs and MicroRNAs in the sperm nuclei. Biol Reprod 78,896-902.
Yang, X., Kubota, C., Suzuki, H., Taneja, M., Bols, P.E., and Presicce, G.A. (1998). Control of oocyte maturation in cows--biological factors. Theriogenology 49,471-482.
Yang, Y.Z., Balla, A., Danilovich, N., and Sairam, M.R. (2003). Developmental and molecular aberrations associated with deterioration of oogenesis during complete or partial follicle-stimulating hormone receptor deficiency in mice. Biol Reprod 69,1294-1302.
Yao, G, Yin, M., Lian, J., Tian, H., Liu, L., Li, X., and Sun, F. (2010). MicroRNA-224 Is Involved in Transforming Growth Factor-beta-Mediated Mouse Granulosa Cell Proliferation and Granulosa Cell Function by Targeting Smad4. Mol Endocrinol 24,540-551.
Yin, M., Lu, M., Yao, G, Tian, H., Lian, J., Liu, L., Liang, M., Wang, Y, and Sun, F. (2012). Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by targeting RBMS1. Mol Endocrinol 26,1129-1143.
Ying, Y., Qi, X.X., and Zhao, GQ. (2001). Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways. Proc Natl Acad Sci U S A 98,7858-7862.
Ying, Y, and Zhao, G.Q. (2001). Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. Dev Biol 232,484-492.
Young, L.E., Sinclair, K.D., and Wilmut, I. (1998). Large offspring syndrome in cattle and sheep. Rev Reprod 3,155-163.
Yu, N., and Roy, S.K. (1999). Development of primordial and prenatal follicles from undifferentiated somatic cells and oocytes in the hamster prenatal ovary in vitro:Effect of insulin. Biol Reprod 61,1558-1567.
Zeng, Y., and Cullen, B.R. (2003). Sequence requirements for micro RNA processing and function in human cells. RNA 9,112-123.
Zeng, Y., and Cullen, B.R. (2004). Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res 32,4776-4785.
Zeng, Y., Wagner, E.J., and Cullen, B.R. (2002). Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell 9,1327-1333.
Zeng, Y., Yi, R., and Cullen, B.R. (2003). MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci U S A100,9779-9784.
Zhao, J., Dorland, M., Taverne, M.A.M., Van der Weijden, G.C., Bevers, M.M., and Van den Hurk, R. (2000). In vitro culture of rat pre-antral follicles with emphasis on follicular interactions. Mol Reprod Dev 55, 65-74.
Zhao, J., Taverne, M.A.M., van der Weijden, G.C., Bevers, M.M., and van den Hurk, R. (2001). Effect of activin A on in vitro development of rat preantral follicles and localization of activin A and activin receptor Ⅱ. Biol Reprod 65,967-977.
Zhou, H.M., and Zhang, Y. (2005). Effect of growth factors on in vitro development of caprine preantral follicle oocytes. Anim Reprod Sci 90,265-272.
Zhou, Y., Zhu, Y., Zhang, S., Wang, H., Wang, S., and Yang, X. (2011). MicroRNA expression profiles in premature ovarian failure patients and its potential regulate functions. Chinese journal of birth health and heredity 19,20-22.
Abir, R., Fisch, B., Nitke, S., Okon, E., Raz, A., and Ben Rafael, Z. (2001). Morphological study of fully and partially isolated early human follicles. Fertil Steril 75,141-146.
Abir, R., Franks, S., Mobberley, M.A., Moore, P.A., Margara, R.A., and Winston, R.M.L. (1997). Mechanical isolation and in vitro growth of preantral and small antral human follicles. Fertil Steril 68,682-688.
Abir, R., Orvieto, R., Dicker, D., Zukerman, Z., Barnett, M., and Fisch, B. (2002). Preliminary studies on apoptosis in human fetal ovaries. Fertil Steril 78,259-264.
Abir, R., Roizman, P., Fisch, B., Nitke, S., Okon, E., Orvieto, R., and Ben Rafael, Z. (1999). Pilot study of isolated early human follicles cultured in collagen gels for 24 hours. Hum Reprod 14,1299-1301.
Adam, A., Takahashi, Y., Katagiri, S., and Nagano, M. (2004). In vitro culture of mouse preantral follicles using membrane inserts and developmental competence of in vitro ovulated oocytes. J Reprod Develop 50,579.
Adashi, E., and Hsueh, A. (1982). Estrogens augment the stimulation of ovarian aromatase activity by follicle-stimulating hormone in cultured rat granulosa cells. J Biol Chem 257,6077-6083.
Adashi, E.Y., Resnick, C.E., Hernandez, E.R., May, J.V., Purchio, A.F., and Twardzik, D.R. (1989). Ovarian transforming growth factor-beta (tgf-beta)-cellular site(s), and mechanism(s) of action. Mol Cell Endocrinol 61,247-256.
Adhikari, D., Zheng, W., Shen, Y., Gorre, N., Hamalainen, T., Cooney, A.J., Huhtaniemi, I., Lan, Z.J., and Liu, K. (2010). Tsc/mTORCl signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet 19,397-410.
Adriaens, I., Cortvrindt, R., and Smitz, J. (2004). Differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence. Hum Reprod 19,398-408.
Alak, B.M., Coskun, S., Friedman, C.I., Kennard, E.A., Kim, M.H., and Seifer, D.B. (1998). Activin A stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro. Fertil Steril 70,1126-1130.
Alak, B.M., Smith, G.D., Woodruff, T.K., Stouffer, R.L., and Wolf, D.P. (1996). Enhancement of primate oocyte maturation and fertilization in vitro by inhibin A and activin A. Fertil Steril 66,646-653.
Amanai, M., Brahmajosyula, M., and Perry, A.C. (2006). A restricted role for sperm-borne microRNAs in mammalian fertilization. Biol Reprod 75,877-884.
Armstrong, D.G., Baxter, G, Hogg, C.O., and Woad, K.J. (2002). Insulin-like growth factor (IGF) system in the oocyte and somatic cells of bovine preantral follicles. Reproduction 123,789-797.
Baerwald, A.R., Adams, GP., and Pierson, R.A. (2003). Characterization of ovarian follicular wave dynamics in women. Biol Reprod 69,1023-1031.
Baker, S.J., Srsen, V., Lapping, R., and Spears, N. (2001). Combined effect of follicle-follicle interactions and declining follicle-stimulating hormone on murine follicle health in vitro. Biol Reprod 65, 1304-1310.
Baker, T.G. (1963).A quantitative and cytological study of germ cells in human ovaries. P Roy Soc B-Biol Sci 158,417-420.
Baker, T.G, and Neal, P. (1974). Organ-culture of cortical fragments and graafian follicles from human ovaries. J Anat 117,361-371.
Bartel, D.P. (2004). MicroRNAs:genomics, biogenesis, mechanism, and function. Cell 116,281-297.
Baulcombe, D. (2002). DNA events. An RNA microcosm. Science 297,2002-2003.
Beaujean, N., Hartshorne, G., Cavilla, J., Taylor, J., Gardner, J., Wilmut, I., Meehan, R., and Young, L. (2004). Non-conservation of mammalian preimplantation methylation dynamics. Curr Biol 14, R266-267.
Berkholtz, C.B., Shea, L.D., and Woodruff, T.K. (2006). Extracellular matrix functions in follicle maturation. Semin Reprod Med 24,262-269.
Bernstein, E., Caudy, A.A., Hammond, S.M., and Hannon, G.J. (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409,363-366.
Biggers, J.D., Whittingham, D.G., and Donahue, R.P. (1967). The pattern of energy metabolism in the mouse oocyte and zygote. Proc Natl Acad Sci U S A 58,560-567.
Bissell, M.J., Rizki, A., and Mian, I.S. (2003). Tissue architecture:the ultimate regulator of breast epithelial function. Curr Opin Cell Biol 15,753-762.
Blandau, R.J., Warrick, E., and Rumery, R.E. (1965). In vitro cultivation of fetal mouse ovaries. Fertil Steril 16,705-715.
Boland, N.I., and Gosden, R.G. (1994). Effects of epidermal growth factor on the growth and differentiation of cultured mouse ovarian follicles. J Reprod Fertil 101,369-374.
Boland, N.I., Humpherson, P.G, Leese, H.J., and Gosden, R.G. (1993). Pattern of lactate production and steroidogenesis during growth and maturation of mouse ovarian follicles invitro. Biol Reprod 48, 798-806.
Borghol, N., Lornage, J., Blachere, T., Garret, A.S., and Lefevre, A. (2006). Epigenetic status of the H19 locus in human oocytes following in vitro maturation. Genomics 87,417-426.
BrawTal, R., and Yossefi, S. (1997). Studies in vivo and in vitro on the initiation of follicle growth in the bovine ovary. J Reprod Fertil 109,165-171.
Bukowski, R.M., Olencki, T., McLain, D., and Finke, J.H. (1994). Pleiotropic effects of cytokines:clinical and preclinical studies. Stem Cells 12 Suppl 1,129-140; discussion 140-121.
Cain, L., Chatterjee, S., and Collins, T.J. (1995). In-vitro folliculogenesis of rat preantral follicles. Endocrinology 136,3369-3377.
Campbell, B.K., Scaramuzzi, R.J., and Webb, R. (1996). Induction and maintenance of oestradiol and immunoreactive inhibin production with FSH by ovine granulosa cells cultured in serum-free media. J Reprod Fertil 106,7-16.
Carabatsos, M.J., Elvin, J., Matzuk, M.M., and Albertini, D.F. (1998). Characterization of oocyte and follicle development in growth differentiation factor-9-deficient mice. Dev Biol 204,373-384.
Carambula, S.F., Goncalves, P.B.D., Costa, L.F.S., Figueiredo, J.R., Wheeler, M.B., Neves, J.P., and Mondadori, R.G (1999). Effect of fetal age and method of recovery on isolation of preantral follicles from bovine ovaries. Theriogenology 52,563-571.
Carletti, M.Z., Fiedler, S.D., and Christenson, L.K. (2010). MicroRNA 21 Blocks Apoptosis in Mouse Periovulatory Granulosa Cells. Biol Reprod 83,286-295.
Carmell, M.A., and Hannon, G.J. (2004). RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol 11,214-218.
Carroll, J., and Gosden, R.G. (1993). Transplantation of frozen-thawed mouse primordial follicles. Hum Reprod 8,1163-1167.
Carroll, J., Whittingham, D.G, and Wood, M.J. (1991a). Effect of dibutyryl cyclic adenosine-monophosphate on granulosa-cell proliferation, oocyte growth and meiotic maturation in isolated mouse primary ovarian follicles cultured in collagen gels. J Reprod Fertil 92,197-207.
Carroll, J., Whittingham, D.G., and Wood, M.J. (1991b). Growth-invitro and acquisition of meiotic competence after the cryopreservation of isolated mouse primary ovarian follicles. Reprod Fert Develop 3,593-599.
Castrillon, D.H., Miao, L.L., Kollipara, R., Horner, J.W., and DePinho, R.A. (2003). Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301,215-218.
Cecconi, S., Barboni, B., Coccia, M., and Mattioli, M. (1999). In vitro development of sheep preantral follicles. Biol Reprod 60,594-601.
Cecconi, S., Rossi, G, Coticchio, G., Macchiarelli, G., Borini, A., and Canipari, R. (2004). Influence of thyroid hormone on mouse preantral follicle development in vitro. Fertil Steril 81,919-924.
Chang, S.C.S., Anderson, W., Lewis, J.C., Ryan, R.J., and Kang, Y.H. (1977). Porcine ovarian follicle.2. electron-microscopic study of surface features of granulosa-cells at different stages of development. Biol Reprod 16,349-357.
Chegini, N., and Flanders, K.C. (1992). Presence of transforming growth-factor-beta and their selective cellular-localization in human ovarian tissue of various reproductive stages. Endocrinology 130, 1707-1715.
Cheng, L., Gearing, D.P., White, L.S., Compton, D.L., Schooley, K., and Donovan, P.J. (1994). Role of leukemia inhibitory factor and its receptor in mouse primordial germ cell growth. Development 120, 3145-3153.
Cho, J.-H., Itoh, T., Sendai, Y, and Hoshi, H. (2008). Fibroblast Growth Factor 7 Stimulates In Vitro Growth of Oocytes Originating From Bovine Early Antral Follicles. Mol Reprod Dev 75,1736-1743.
Clark, A.R., Stokes, Y.M., Lane, M., and Thompson, J.G (2006). Mathematical modelling of oxygen concentration in bovine and murine cumulus-oocyte complexes. Reproduction 131,999-1006.
Conti, M., Andersen, C.B., Richard, F., Mehats, C., Chun, S.Y., Horner, K., Jin, C., and Tsafriri, A. (2002). Role of cyclic nucleotide signaling in oocyte maturation. Mol Cell Endocrinol 187,153-159.
Cortvrindt, R., Hu, Y, and Smitz, J. (1998). Recombinant luteinizing hormone as a survival and differentiation factor increases oocyte maturation in recombinant follicle stimulating hormone-supplemented mouse preantral follicle culture. Hum Reprod 13,1292-1302.
Cortvrindt, R., Smitz, J., and VanSteirteghem, A.C. (1996). In-vitro maturation, fertilization and embryo development of immature oocytes from early preantral follicles from prepuberal mice in a simplified culture system. Hum Reprod 11,2656-2666.
Cortvrindt, R., Smitz, J., and VanSteirteghem, A.C. (1997). Assessment of the need for follicle stimulating hormone in early preantral mouse follicle culture in vitro. Hum Reprod 12,759-768.
Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., et al. (2001). The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Gene 27,159-166.
Cushman, R.A., Wahl, C.M., and Fortune, J.E. (2002). Bovine ovarian cortical pieces grafted to chick embryonic membranes:A model for studies on the activation of primordial follicles. Hum Reprod 17, 48-54.
Daniel, S.A.J., Armstrong, D.T., and Gorelangton, R.E. (1989). Growth and development of rat oocytes invitro. Gamete Res 24,109-121.
De Baere, E., Beysen, D., Oley, C., Lorenz, B., Cocquet, J., De Sutter, P., Devriendt, K., Dixon, M., Fellous, M., Fryns, J.P., et al. (2003). FOXL2 and BPES:Mutational hotspots, phenotypic variability, and revision of the genotype-phenotype correlation. Am J Hum Genet 72,478-487.
de Vet, A., Laven, J.S.E., de Jong, F.H., Themmen, A.P.N., and Fauser, B. (2002). Antimullerian hormone serum levels:a putative marker for ovarian aging. Fertil Steril 77,357-362.
Demeestere, I., Gervy, C., Centner, J., Devreker, F., Englert, Y., and Delbaere, A. (2004). Effect of insulin-like growth factor-I during preantral follicular culture on steroidogenesis, in vitro oocyte maturation, and embryo development in mice. Biol Reprod 70,1664-1669.
Denli, A.M., Tops, B.B., Plasterk, R.H., Ketting, R.F., and Hannon, G.J. (2004). Processing of primary microRNAs by the Microprocessor complex. Nature 432,231-235.
DePaola, N., Davies, P.F., Pritchard, W.F., Jr., Florez, L., Harbeck, N., and Polacek, D.C. (1999). Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro. Proc Natl Acad Sci U S A 96,3154-3159.
Devine, P.J., Rajapaksa, K.S., and Hoyer, P.B. (2002). In vitro ovarian tissue and organ culture:A review. Front Biosci 7, D1979-D1989.
Di Pasquale, E., Beck-Peccoz, P., and Persani, L. (2004). Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. Am J Hum Genet 75, 106-111.
Dierich, A., Sairam, M.R., Monaco, L., Fimia, GM., Gansmuller, A., LeMeur, M., and Sassone-Corsi, P. (1998). Impairing follicle-stimulating hormone (FSH) signaling in vivo:Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A 95, 13612-13617.
Dodson, W.C., and Schomberg, D.W. (1987). The effect of transforming growth-factor-beta on follicle-stimulating hormone-induced differentiation of cultured rat granulosa-cells. Endocrinology 120, 512-516.
Dong, J., Albertini, D.F., Nishimori, K., Kumar, T.R., Lu, N., and Matzuk, M.M. (1996). Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 383,531-535
Downs, S.M., Daniel, S.A.J., Bornslaeger, E.A., Hoppe, P.C., and Eppig, J.J. (1989). Maintenance of meiotic arrest in mouse oocytes by purines-modulation of camp levels and camp phosphodiesterase activity. Gamete Res 23,323-334.
Durlinger, A.L., Gruijters, M.J., Kramer, P., Karels, B., Ingraham, H.A., Nachtigal, M.W., Uilenbroek, J.T., Grootegoed, J.A., and Themmen, A.P. (2002). Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology 143,1076-1084.
Durlinger, A.L., Gruijters, M.J., Kramer, P., Karels, B., Kumar, T.R., Matzuk, M.M., Rose, U.M., de Jong, F.H., Uilenbroek, J.T., Grootegoed, J.A., et al. (2001). Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology 142,4891-4899.
Durlinger, A.L., Kramer, P., Karels, B., de Jong, F.H., Uilenbroek, J.T., Grootegoed, J.A., and Themmen, A.P. (1999). Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endocrinology 140,5789-5796.
Ebner, T., Sommergruber, M., Moser, M., Shebl, O., Schreier-Lechner, E., and Tews, G. (2006). Basal level of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles. Hum Reprod 21, 2022-2026.
Eppig, J.J. (1976). Analysis of mouse oogenesis invitro oocyte isolation and utilization of exogenous energy-sources by growing oocytes. J Exp Zool 198,375-381.
Eppig, J.J. (1991). Maintenance of meiotic arrest and the induction of oocyte maturation in mouse oocyte-granulosa cell complexes developed invitro from preantral follicles. Biol Reprod 45,824-830.
Eppig, J.J. (1994). Further reflections on culture systems for the growth of oocytes in-vitro. Hum Reprod 9, 974-976.
Eppig, J.J. (2001). Oocyte control of ovarian follicular development and function in mammals. Reproduction 122,829-838.
Eppig, J.J., and Downs, S.M. (1987). The effect of hypoxanthine on mouse oocyte growth and development invitro-maintenance of meiotic arrest and gonadotropin-induced oocyte maturation. Dev Biol 119, 313-321.
Eppig, J.J., and O'Brien, M.J. (1998). Comparison of preimplantation developmental competence after mouse oocyte growth and development in vitro and in vivo. Theriogenology 49,415-422.
Eppig, J.J., O'Brien, M.J., Pendola, F.L., and Watanabe, S. (1998). Factors affecting the developmental competence of mouse oocytes grown in vitro:Follicle-stimulating hormone and insulin. Biol Reprod 59, 1445-1453.
Eppig, J.J., Obrien, M., and Wigglesworth, K. (1996). Mammalian oocyte growth, and development in vitro. Mol Reprod Dev 44,260-273.
Eppig, J.J., and Obrien, M.J. (1996). Development in vitro of mouse oocytes from primordial follicles. Biol Reprod 54,197-207.
Eppig, J.J., and Schroeder, A.C. (1989). Capacity of mouse oocytes from preantral follicles to undergo embryogenesis and development to live young after growth, maturation, and fertilization invitro. Biol Reprod 41,268-276.
Eppig, J.J., Schroeder, A.C., Vandesandt, J.J.M., Ziomek, C.A., and Bavister, B.D. (1990). Developmental capacity of mouse oocytes that grow and mature in culture-the effect of modification of the protocol. Theriogenology 33,89-100.
Eppig, J.J., Wardbailey, P.F., and Coleman, D.L. (1985). Hypoxanthine and adenosine in murine ovarian follicular-fluid-concentrations and activity in maintaining oocyte meiotic arrest. Biol Reprod 33, 1041-1049.
Eppig, J.J., and Wigglesworth, K. (1995). Factors affecting the developmental competence of mouse oocytes grown in-vitro-oxygen concentration. Mol Reprod Dev 42,447-456.
Eppig, J.J., Wigglesworth, K., and Obrien, M.J. (1992). Comparison of embryonic developmental competence of mouse oocytes grown with and without serum. Mol Reprod Dev 32,33-40.
Eppig, J.J., Wigglesworth, K., and Pendola, F.L. (2002). The mammalian oocyte orchestrates the rate of ovarian follicular development. Proc Natl Acad Sci U S A 99,2890-2894.
Erickson, B.H. (1966). Development and senescence of the postnatal bovine ovary. J Anim Sci 25,800-805.
Erickson, G.F., and Shimasaki, S. (2003). The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Reprod Biol Endocrin:RB&E 1,9-9.
Farh, K.K., Grimson, A., Jan, C., Lewis, B.P., Johnston, W.K., Lim, L.P., Burge, C.B., and Bartel, D.P. (2005). The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science 310, 1817-1821.
Fernandez-Gonzalez, R., Moreira, P., Bilbao, A., Jimenez, A., Perez-Crespo, M., Ramirez, M.A., De Fonseca, F.R., Pintado, B., and Gutierrez-Adan, A. (2004). Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior. Proc Natl Acad Sci U SA101,5880-5885.
Figueiredo, J., Hulshof, S., Thiry, M., Van den Hurk, R., Bevers, M., Nusgens, B., and Beckers, J.-F. (1995). Extracellular matrix proteins and basement membrane:their identification in bovine ovaries and significance for the attachment of cultured preantral follicles. Theriogenology 43,845-858.
Figueiredo, J.R., Hulshof, S.C., Van den Hurk, R., Ectors, FJ., Fontes, R.S., Nusgens, B., Bevers, M.M., and Beckers, J.F. (1993). Development of a combined new mechanical and enzymatic method for the isolation of intact preantral follicles from fetal, calf and adult bovine ovaries. Theriogenology 40, 789-799.
Figueiredo, J.R., Hulshof, S.C.J., Vandenhurk, R., Nusgens, B., Bevers, M.M., Ectors, F.J., and Beckers, J.F. (1994). Preservation of oocyte and granulosa-cell morphology in bovine preantral follicles cultured in-vitro. Theriogenology 41,1333-1346.
Fire, A., Xu, S.Q., Montgomery, M.K., Kostas, S.A., Driver, S.E., and Mello, C.C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391,806-811.
Fletcher, C.E., Dart, D.A., Sita-Lumsden, A., Cheng, H., Rennie, P.S., and Bevan, C.L. (2012). Androgen-regulated processing of the oncomir MiR-27a, which targets Prohibitin in prostate cancer. Hum Mol Genet 21,3112-3127.
Fortune, J.E., Cushman, R.A., Wahl, C.M., and Kito, S. (2000). The primordial to primary follicle transition. Mol Cell Endocrinol 163,53-60.
Fortune, J.E., Kito, S., Wandji, S.A., and Srsen, V. (1998). Activation of bovine and baboon primordial follicles in vitro. Theriogenology 49,441-449.
Franchimont, P., Hazee-Hagelstein, M.T., Charlet-Renard, C., and Jaspar, J.M. (1986). Effect of mouse epidermal growth factor on DNA and protein synthesis, progesterone and inhibin production by bovine granulosa cells in culture. Acta Endocrinol (Copenh) 111,122-127.
Fulka, H., Mrazek, M., Tepla, O., and Fulka, J. (2004). DNA methylation pattern in human zygotes and developing embryos. Reproduction 128,703-708.
Gallardo, T.D., John, G.B., Bradshaw, K., Welt, C., Reijo-Pera, R., Vogt, P.H., Touraine, P., Bione, S., Toniolo, D., and Nelson, L.M. (2008). Sequence variation at the human FOXO3 locus:a study of premature ovarian failure and primary amenorrhea. Hum Reprod 23,216-221.
Galloway, S.M., McNatty, K.P., Cambridge, L.M., Laitinen, M.P.E., Juengel, J.L., Jokiranta, T.S., McLaren, R.J., Luiro, K., Dodds, K.G., Montgomery, G.W., et al. (2000). Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat Gene 25,279-283.
Gandolfi, F., Milanesi, E., Pocar, P., Luciano, A.M., Brevini, T.A.L., Acocella, F., Lauria, A., and Armstrong, D.T. (1998). Comparative analysis of calf and cow oocytes during in vitro maturation. Mol Reprod Dev 49,168-175.
Gigli, I., Byrd, D., and Fortune, J. (2006). Effects of oxygen tension and supplements to the culture medium on activation and development of bovine follicles in vitro. Theriogenology 66,344-353.
Gilchrist, R.B., Ritter, L.J., Myllymaa, S., Kaivo-Oja, N., Dragovic, R.A., Hickey, T.E., Ritvos, O., and Mottershead, D.G. (2006). Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation. J Cell Sci 119,3811-3821.
Gill, A., Jamnongjit, M., and Hammes, S.R. (2004). Androgens promote maturation and signaling in mouse oocytes independent of transcription:A release of inhibition model for mammalian oocyte meiosis. Mol Endocrinol 18,97-104.
Goldenberg, R.L., Powell, R.D., Rosen, S.W., Marshall, J.R., and Ross, GT. (1976). Ovarian morphology in women with anosmia and hypogonadotropic hypogonadism. Am J Obstet Gynecol 126,91-94.
Gook, D.A., Edgar, D.H., and Stern, C. (2004). Cryopreservation of human ovarian tissue. Eur J Obstet Gynecol Reprod Biol 113 Suppl 1, S41-44.
Gore-Langton, R.E., and Daniel, S.A. (1990). Follicle-stimulating hormone and estradiol regulate antrum-like reorganization of granulosa cells in rat preantral follicle cultures. Biol Reprod 43,65-72.
Gosden, R., and TELFER, E. (1987). Numbers of follicles and oocytes in mammalian ovaries and their allometric relationships. J Zool 211,169-175.
Gosden, R.G., and Byattsmith, J.G. (1986). Oxygen concentration gradient across the ovarian follicular epithelium-model, predictions and implications. Hum Reprod 1,65-68.
Gospodarowicz, D., Ill, C.R., and Birdwell, C.R. (1977). Effects of fibroblast and epidermal growth factors on ovarian cell proliferation in vitro. I. Characterization of the response of granulosa cells to FGF and EGF. Endocrinology 100,1108-1120.
Gougeon, A. (1996). Regulation of ovarian follicular development in primates:Facts and hypotheses. Endocr Rev 17,121-155.
Greenwald, GS., and Moor, R.M. (1989). Isolation and preliminary characterization of pig primordial follicles. J Reprod Fertil 87,561-571.
Gregory, R.I., Yan, K.P., Amuthan, G, Chendrimada, T., Doratotaj, B., Cooch, N., and Shiekhattar, R. (2004). The Microprocessor complex mediates the genesis of microRNAs. Nature 432,235-240.
Griffith, L.G, and Swartz, MA. (2006). Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7,211-224.
Grishok, A., Pasquinelli, A.E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D.L., Fire, A., Ruvkun, G, and Mello, C.C. (2001). Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans. Developmental Timing. Cell 106,23-34.
Guo, Q., Kumar, T.R., Woodruff, T., Hadsell, L.A., DeMayo, F.J., and Matzuk, M.M. (1998). Overexpression of mouse follistatin causes reproductive defects in transgenic mice. Mol Endocrinol 12,96-106.
Gutierrez, C.G, Ralph, J.H., Telfer, E.E., Wilmut, I., and Webb, R. (2000). Growth and antrum formation of bovine preantral follicles in long-term culture in vitro. Biol Reprod 62,1322-1328.
Hanrahan, J.P., Gregan, S.M., Mulsant, P., Mullen, M., Davis, GH., Powell, R., and Galloway, S.M. (2004). Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). Biol Reprod 70, 900-909.
Harada, M., Miyano, T., Matsumura, K., Osaki, S., Miyake, M., and Kato, S. (1997). Bovine oocytes from early antral follicles grow to meiotic competence in vitro:Effect of FSH and hypoxanthine. Theriogenology 48,743-755.
Harris, S.E., Adriaens, I., Leese, H.J., Gosden, R.G, and Picton, H.M. (2007). Carbohydrate metabolism by murine ovarian follicles and oocytes grown in vitro. Reproduction 134,415-424.
Harris, S.E., Leese, H.J., Gosden, R.G, and Picton, H.M. (2009). Pyruvate and Oxygen Consumption Throughout the Growth and Development of Murine Oocytes. Mol Reprod Dev 76,231-238.
Hartshorne, GM. (1997). In vitro culture of ovarian follicles. Rev Reprod 2,94-104.
Hartshorne, GM., Sargent, I.L., and Barlow, D.H. (1994). Meiotic progression of mouse oocytes throughout follicle growth and ovulation in-vitro. Hum Reprod 9,352-359.
Hashimoto, S., Ohsumi, K., Tsuji, Y, Harauma, N., Miyata, Y., Fukuda, A., Hosoi, Y., Iritani, A., and Morimoto, Y. (2007). Growing porcine oocyte-granulosa cell complexes acquired meiotic competence during in vitro culture. J Reprod Develop 53,379-384.
Haug, A., Larsen, B., and Smidsrod, O. (1967). Studies on sequence of uronic acid residues in alginic acid. Acta Chem Scand 21,691-&.
Hayashi, M., McGee, E.A., Min, G, Klein, C., Rose, U.M., van Duin, M., and Hsueh, A.J.W. (1999). Recombinant growth differentiation factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles. Endocrinology 140,1236-1244.
He, L., Thomson, J.M., Hemann, M.T., Hernando-Monge, E., Mu, D., Goodson, S., Powers, S., Cordon-Cardo, C., Lowe, S.W., Hannon, GJ., et al. (2005). A microRNA polycistron as a potential human oncogene. Nature 435,828-833.
Heise, M., Koepsel, R., Russell, A.J., and McGee, E.A. (2005). Calcium alginate microencapsulation of ovarian follicles impacts FSH delivery and follicle morphology. Reprod Biol Endocrinol 3,47.
Heise, M.K., Koepsel, R., McGee, E.A., and Russell, A.J. (2009). Dynamic oxygen enhances oocyte maturation in long-term follicle culture. Tissue Eng Part C Methods 15,323-332.
Hirao, Y, Itoh, T., Shimizu, M., Iga, K., Aoyagi, K., Kobayashi, M., Kacchi, M., Hoshi, H., and Takenouchi, N. (2004). In vitro growth and development of bovine oocyte-granulosa cell complexes on the flat substratum:Effects of high polyvinylpyrrolidone concentration in culture medium. Biol Reprod 70, 83-91.
Hirao, Y., and Miyano, T. (2008). In vitro growth of mouse oocytes:oocyte size at the beginning of culture influences the appropriate length of culture period. Journal of Mammalian Ova Research 25,56-62.
Hirao, Y, Nagai, T., Kubo, M., Miyano, T., Miyake, M., and Kato, S. (1994). In-vitro growth and maturation of pig oocytes. J Reprod Fertil 100,333-339.
Hirao, Y, Shimizu, M., Iga, K., and Takenouchi, N. (2009). Growth of Bovine Oocyte-Granulosa Cell Complexes Cultured Individually in Microdrops of Various Sizes. J Reprod Develop 55,88-93.
Hossain, M.M., Ghanem, N., Hoelker, M., Rings, F., Phatsara, C., Tholen, E., Schellander, K., and Tesfaye, D. (2009). Identification and characterization of miRNAs expressed in the bovine ovary. BMC Genomics 10,443.
Hovatta, O. (2004). Cryopreservation and culture of human ovarian cortical tissue containing early follicles. Eur J Obstet Gynecol Reprod Biol 113 Suppl 1, S50-54.
Hovatta, O., Silye, R., Abir, R., Krausz, T., and Winston, R. (1997). Extracellular matrix improves survival of both stored and fresh human primordial and primary ovarian follicles in long-term culture. Hum Reprod 12,1032-1036.
Hovatta, O., Wright, C., Krausz, T., Hardy, K., and Winston, R.M.L. (1999). Human primordial, primary and secondary ovarian follicles in long-term culture:effect of partial isolation. Hum Reprod 14,2519-2524.
Hrabia, A., Ha, Y, and Shimada, K. (2004). Expression of estrogen receptor mRNA in theca and granulosa layers of the ovary in relation to follicular growth in quail. Folia Biologica 52,3-4.
Hreinsson, J.G, Scott, J.E., Rasmussen, C., Swahn, M.L., Hsueh, A.J.W., and Hovatta, O. (2002). Growth differentiation factor-9 promotes the growth, development, and survival of human ovarian follicles in organ culture. J Clin Endocr Metab 87,316-321.
Hsueh, A., Dahl, K.D., Vaughan, J., Tucker, E., Rivier, J., Bardin, C.W., and Vale, W. (1987). Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc Natl Acad Sci U S A 84,5082-5086.
Hsueh, A.J., BILLIG, H., and Tsafriri, A. (1994). Ovarian follicle atresia:a hormonally controlled apoptotic process. Endocr Rev 15,707-724.
Hu, Y, Betzendahl, I., Cortvrindt, R., Smitz, J., and Eichenlaub-Ritter, U. (2001). Effects of low O(2) and ageing on spindles and chromosomes in mouse oocytes from pre-antral follicle culture. Hum Reprod 16, 737-748.
Hudson, P.L., Dougas, I., Donahoe, P.K., Cate, R.L., Epstein, J., Pepinsky, R.B., and Maclaughlin, D.T. (1990). An immunoassay to detect human mullerian inhibiting substance in males and females during normal development. J Clin Endocr Metab 70,16-22.
Hulshof, S.C.J., Figueiredo, J.R., Beckers, J.F., Bevers, M.M., Vanderdonk, J.A., and Vandenhurk, R. (1995). effects of fetal bovine serum, fsh and 17-beta-estradiol on the culture of bovine preantral follicles. Theriogenology 44,217-226.
Huntriss, J., Gosden, R., Hinkins, M., Oliver, B., Miller, D., Rutherford, A.J., and Picton, H.M. (2002). Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes. Molecular Hum Reprod 8,1087-1095.
Huntriss, J., and Picton, H.M. (2008). Epigenetic consequences of assisted reproduction and infertility on the human preimplantation embryo. Hum Fertil (Cambridge, England) 11,85-94.
Hutvagner, G, McLachlan, J., Pasquinelli, A.E., Balint, E., Tuschl, T., and Zamore, P.D. (2001). A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293,834-838.
Hutvagner, G, and Zamore, P.D. (2002). A microRNA in a multiple-turnover RNAi enzyme complex. Science 297,2056-2060.
Huynh, K., Jones, G., Thouas, G, Britt, K.L., Simpson, E.R., and Jones, M.E.E. (2004). Estrogen is not directly required for oocyte developmental competence. Biol Reprod 70,1263-1269.
Hwa, A.J., Fry, R.C., Sivaraman, A., So, P.T., Samson, L.D., Stolz, D.B., and Griffith, L.G (2007). Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes. FASEB J 21,2564-2579.
Hwang, H.W., and Mendell, J.T. (2007). MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 96 Suppl, R40-44.
Ikeda, Y.-h., Hirao, Y., and Miyano, T. (1999). Effects of androgens on early development of mouse follicles in organ-cultured ovaries. 日本哺乳动物卵子学会誌 16,148-153.
Imamura, T., Kerjean, A., Heams, T., Kupiec, J.J., Thenevin, C., and Paldi, A. (2005). Dynamic CpG and non-CpG methylation of the Pegl/Mest gene in the mouse oocyte and preimplantation embryo. J Biol Chem 280,20171-20175.
Iorio, M.V., Visone, R., Di Leva, G, Donati, V., Petrocca, F., Casalini, P., Taccioli, C., Volinia, S., Liu, C.-G., Alder, H., et al. (2007). MicroRNA signatures in human ovarian cancer. Cancer Res 67,8699-8707.
Ireland, J., Zielak-Steciwko, A., Jimenez-Krassel, F., Folger, J., Bettegowda, A., Scheetz, D., Walsh, S., Mossa, F., Knight, P., and Smith, G. (2009). Variation in the ovarian reserve is linked to alterations in intrafollicular estradiol production and ovarian biomarkers of follicular differentiation and oocyte quality in cattle. Biol Reprod 80,954-964.
Itoh, T., and Hoshi, H. (2000). Efficient isolation and long-term viability of bovine small preantral follicles in vitro. In Vitro Cell Dev Biol Anim 36,235-240.
Itoh, T., Kacchi, M., Abe, H., Sendai, Y., and Hoshi, H. (2002). Growth, antrum formation, and estradiol production of bovine preantral follicles cultured in a serum-free medium. Biol Reprod 67,1099-1105.
Jewgenow, K. (1996). Impact of peptide growth factors on the culture of small preantral follicles of domestic cats. Theriogenology 45,889-895.
Jewgenow, K. (1998). Role of media, protein and energy supplements on maintenance of morphology and DNA-synthesis of small preantral domestic cat follicles during short-term culture. Theriogenology 49, 1567-1577.
John, GB., Gallardo, T.D., Shirley, L.J., and Castrillon, D.H. (2008). Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth. Dev Biol 321,197-204.
Joyce, I.M., Clark, A.T., Pendola, F.L., and Eppig, J.J. (2000). Comparison of recombinant growth differentiation factor-9 and oocyte regulation of KIT ligand messenger ribonucleic acid expression in mouse ovarian follicles. Biol Reprod 63,1669-1675.
Joyce, I.M., Pendola, F.L., Wigglesworth, K., and Eppig, J.J. (1999). Oocyte regulation of kit ligand expression in mouse ovarian follicles. Dev Biol 214,342-353.
Juengel, J.L., Hudson, N.L., Berg, M., Hamel, K., Smith, P., Lawrence, S.B., Whiting, L., and McNatty, K.P. (2009). Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle. Reproduction 138,107-114.
Juengel, J.L., Hudson, N.L., Heath, D.A., Smith, P., Reader, K.L., Lawrence, S.B., O'Connell, A.R., Laitinen, M.P.E., Cranfield, M., Groome, N.P., et al. (2002). Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep. Biol Reprod 67, 1777-1789.
Juengel, J.L., and McNatty, K.P. (2005). The role of proteins of the transforming growth factor-beta superfamily in the intraovarian regulation of follicular development. Hum Reprod Update 11,143-160.
Juneja, S.C., Barr, K.J., Enders, G.C., and Kidder, G.M. (1999). Defects in the germ line and gonads of mice lacking connexin43. Biol Reprod 60,1263-1270.
Katska, L., Alm, H., and Rynska, B. (2000). Nuclear configuration of bovine oocytes derived from fresh and in vitro-cultured preantral and early antral ovarian follicles. Theriogenology 54,247-260.
Katska, L., and Rynska, B. (1998). The isolation and in vitro culture of bovine preantral and early antral follicles of different size classes. Theriogenology 50,213-222.
Kerjean, A., Couvert, P., Heams, T., Chalas, L., Poirier, K., Chelly, J., Jouannet, P., Paldi, A., and Poirot, C. (2003). In vitro follicular growth affects oocyte imprinting establishment in mice. Eur J Hum Genet 11, 493-496.
Ketting, R.F., Fischer, S.E., Bernstein, E., Sijen, T., Hannon, G.J., and Plasterk, R.H. (2001). Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev 15,2654-2659.
Kezele, P., Nilsson, E.E., and Skinner, M.K. (2005). Keratinocyte growth factor acts as a mesenchymal factor that promotes ovarian primordial to primary follicle transition. Biol Reprod 73,967-973.
Kezele, P.R., Nilsson, E.E., and Skinner, M.K. (2002). Insulin but not insulin-like growth factor-1 promotes the primordial to primary follicle transition. Mol Cell Endocrinol 192,37-43.
Khosla, S., Dean, W., Brown, D., Reik, W., and Feil, R. (2001). Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol Reprod 64,918-926.
Khvorova, A., Reynolds, A., and Jayasena, S.D. (2003). Functional siRNAs and miRNAs exhibit strand bias. Cell 115,209-216.
Knight, P.G., and Glister, C. (2006). TGF-beta superfamily members and ovarian follicle development. Reproduction 132,191-206.
Kotsuji, F., Kubo, M., and Tominaga, T. (1994). Effect of interactions between granulosa and thecal cells on meiotic arrest in bovine oocytes. J Reprod Fertil 100,151-156.
Kreeger, P.K., Deck, J.W., Woodruff, T.K., and Shea, L.D. (2006). The in vitro regulation of ovarian follicle development using alginate-extracellular matrix gels. Biomaterials 27,714-723.
Kreeger, P.K., Fernandes, N.N., Woodruff, T.K., and Shea, L.D. (2005). Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose. Biol Reprod 73,942-950.
Lane, M., and Gardner, D.K. (2003). Ammonium induces aberrant blastocyst differentiation, metabolism, pH regulation, gene expression and subsequently alters fetal development in the mouse. Biol Reprod 69, 1109-1117.
Lange, U.C., Saitou, M., Western, P.S., Barton, S.C., and Surani, M.A. (2003). The Fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice. BMC Dev Biol 3, (19 March 2003)-(2019 March 2003).
Lee, R.C., Feinbaum, R.L., and Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75,843-854.
Lee, W.S., Otsuka, F., Moore, R.K., and Shimasaki, S. (2001). Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat. Biol Reprod 65,994-999.
Lee, W.S., Yoon, S.J., Yoon, T.K., Cha, K.Y., Lee, S.H., Shimasaki, S., Lee, S., and Lee, K.A. (2004). Effects of bone morphogenetic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary. Mol Reprod Dev 69,159-163.
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Radmark, O., Kim, S., et al. (2003). The nuclear RNase III Drosha initiates microRNA processing. Nature 425,415-419.
Lee, Y., Jeon, K., Lee, J.T., Kim, S., and Kim, V.N. (2002a). MicroRNA maturation:stepwise processing and subcellular localization. EMBO J 21,4663-4670.
Lee, Y, Yu, X., Gonzales, F., Mangelsdorf, D.J., Wang, M.Y., Richardson, C., Witters, L.A., and Unger, R.H. (2002b). PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci U S A 99,11848-11853.
Leese, H.J., and Barton, A.M. (1984). Pyruvate and glucose-uptake by mouse ova and preimplantation embryos. J Reprod Fertil 72,9-13.
Lenie, S., and Smitz, J. (2009). Functional AR Signaling Is Evident in an In Vitro Mouse Follicle Culture Bioassay That Encompasses Most Stages of Folliculogenesis. Biol Reprod 80,685-695.
Lewis, B.P., Shih, I.H., Jones-Rhoades, M.W., Bartel, D.P., and Burge, C.B. (2003). Prediction of mammalian microRNA targets. Cell 115,787-798.
Li, Y, Yue, P., Deng, X., Ueda, T., Fukunaga, R., Khuri, F.R., and Sun, S.-Y. (2010). Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E. Neoplasia 12,848-855.
Liaw, D., Marsh, D.J., Li, J., Dahia, P.L.M., Wang, S.I., Zheng, Z.M., Bose, S., Call, K.M., Tsou, H.C., Peacocke, M., et al. (1997). Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Gene 16,64-67.
Liu, H.C., He, Z., and Rosenwaks, Z. (2001a). Application of complementary DNA microarray (DNA chip) technology in the study of gene expression profiles during folliculogenesis. Fertil Steril 75,947-955.
Liu, H.C., He, Z., and Rosenwaks, Z. (2002). In vitro culture and in vitro maturation of mouse preantral follicles with recombinant gonadotropins. Fertil Steril 77,373-383.
Liu, J., Van der Elst, J., Van den Broecke, R., and Dhont, M. (2001b). Live offspring by in vitro fertilization of oocytes from cryopreserved primordial mouse follicles after sequential in vivo transplantation and in vitro maturation. Biol Reprod 64,171-178.
Liu, X., Andoh, K., Abe, Y., Kobayashi, J., Yamada, K., Mizunuma, H., and Ibuki, Y. (1999). A comparative study on transforming growth factor-beta and activin A for preantral follicles from adult, immature, and diethylstilbestrol-primed immature mice. Endocrinology 140,2480-2485.
Liu, X., Andoh, K., Yokota, H., Kobayashi, J., Abe, Y., Yamada, K., Mizunuma, H., and Ibuki, Y. (1998). Effects of growth hormone, activin, and follistatin on the development of preantral follicle from immature female mice. Endocrinology 139,2342-2347.
Louhio, H., Hovatta, O., Sjoberg, J., and Tuuri, T. (2000). The effects of insulin, and insulin-like growth factors I and II on human ovarian follicles in long-term culture. Mol Hum Reprod 6,694-698.
Lubahn, D.B., Moyer, J.S., Golding, T.S., Couse, J.F., Korach, K.S., and Smithies, O. (1993). Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A 90,11162-11166.
Lucci, C.M., Rumpf, R., Figueiredo, J.R., and Bao, S.N. (2002). Zebu (Bos indicus) ovarian preantral follicles:morphological characterization and development of an efficient isolation method. Theriogenology 57,1467-1483.
Lund, E., Guttinger, S., Calado, A., Dahlberg, J.E., and Kutay, U. (2004). Nuclear export of microRNA precursors. Science 303,95-98.
Luque-Ramirez, M., San Millan, J.L., and Escobar-Morreale, H.F. (2006). Genomic variants in polycystic ovary syndrome. Clin Chim Acta 366,14-26.
Lussier, J.G., Matton, P., and Dufour, J.J. (1987). Growth rates of follicles in the ovary of the cow. J Reprod Fertil 81,301-307.
Ma, T., Jiang, H., Gao, Y, Zhao, Y, Dai, L., Xiong, Q., Xu, Y, Zhao, Z., and Zhang, J. (2011). Microarray analysis of differentially expressed microRNAs in non-regressed and regressed bovine corpus luteum tissue; microRNA-378 may suppress luteal cell apoptosis by targeting the interferon gamma receptor 1 gene. J Appl Genet 52,481-486.
Mao, J., Smith, M.F., Rucker, E.B., Wu, GM., McCauley, T.C., Cantley, T.C., Prather, R.S., Didion, BA., and Day, B.N. (2004). Effect of epidermal growth factor and insulin-like growth factor I on porcine preantral follicular growth, antrum formation, and stimulation of granulosal cell proliferation and suppression of apoptosis in vitro. J Anim Sci 82,1967-1975.
Matzuk, M.M., Burns, K.H., Viveiros, M.M., and Eppig, J.J. (2002). Intercellular communication in the mammalian ovary:Oocytes carry the conversation. Science 296,2178-2180.
Matzuk, M.M., Kumar, T.R., and Bradley, A. (1995). Different phenotypes for mice deficient in either activins or activin receptor-type-II. Nature 374,356-360.
May, J.V., Frost, J.P., and Schomberg, D.W. (1988). Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. Endocrinology 123,168-179.
McCaffery, F.H., Leask, R., Riley, S.C., and Telfer, E.E. (2000). Culture of bovine preantral follicles in a serum-free system:Markers for assessment of growth and development. Biol Reprod 63,267-273.
McGee, E., Spears, N., Minami, S., Hsu, S.Y., Chun, S.Y., Billig, H., and Hsueh, A.J.W. (1997). Preantral ovarian follicles in serum-free culture:Suppression of apoptosis after activation of the cyclic guanosine 3',5'-monophosphate pathway and stimulation of growth and differentiation by follicle-stimulating hormone. Endocrinology 138,2417-2424.
McGee, E.A., and Hsueh, AJ.W. (2000). Initial and cyclic recruitment of ovarian follicles. Endocr Rev 21, 200-214.
McLaughlin, M., and Telfer, E.E. (2010). Oocyte development in bovine primordial follicles is promoted by activin and FSH within a two-step serum-free culture system. Reproduction 139,971-978.
McNatty, K.P., Smith, P., Hudson, N.L., Heath, D.A., Tisdall, D.J., O, W.S., and Braw-Tal, R. (1995). Development of the sheep ovary during fetal and early neonatal life and the effect of fecundity genes. J Reprod Fertil Suppl 49,123-135.
Mitchell, L.M., Kennedy, C.R., and Hartshorne, G.M. (2002). Effects of varying gonadotrophin dose and timing on antrum formation and ovulation efficiency of mouse follicles in vitro. Hum Reprod 17, 1181-1188.
Mizunuma, H., Liu, X.W., Andoh, K., Abe, Y., Kobayashi, J., Yamada, K., Yokota, H., Ibuki, Y, and Hasegawa, Y. (1999). Activin from secondary follicles causes small preantral follicles to remain dormant at the resting stage. Endocrinology 140,37-42.
Monget, P., Fabre, S., Mulsant, P., Lecerf, F., Elsen, J.M., Mazerbourg, S., Pisselet, C., and Monniaux, D. (2002). Regulation of ovarian folliculogenesis by IGF and BMP system in domestic animals. Domest Anim Endocrinol 23,139-154.
Morimoto, Y., Oku, Y, Sonoda, M., Haruk, A., Ito, K., Hashimoto, S., and Fukuda, A. (2007). High oxygen atmosphere improves human follicle development in organ cultures of ovarian cortical tissues in vitro. Hum Reprod 22,3170-3177.
Morison, I.M., Ramsay, J.P., and Spencer, H.G (2005). A census of mammalian imprinting. Trends Genet 21, 457-465.
Moritake, S., Hirao, Y, and Miyano, T. (2002). Hypoxanthine promotes the acquisition of meiotic competence in pig oocytes from early antral follicles during growth culture.日本哺乳勤物卵子学会誌19,3945.
Moss, E.G., Lee, R.C., and Ambros, V. (1997). The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell 88,637-646.
Mousset-Simeon, N., Jouannet, P., Le Cointre, L., Coussieu, C., and Poirot, C. (2005). Comparison of three in vitro culture systems for maturation of early preantral mouse ovarian follicles. Zygote 13,167-175.
Murchison, E.P., Stein, P., Xuan, Z., Pan, H., Zhang, M.Q., Schultz, R.M., and Hannon, GJ. (2007). Critical roles for Dicer in the female germline. Genes Dev 21,682-693.
Murray, A.A., Gosden, R.G, Allison, V., and Spears, N. (1998). Effect of androgens on the development of mouse follicles growing in vitro. J Reprod Fertil 113,27-33.
Murray, A.A., Swales, A.K.E., Smith, R.E., Molinek, M.D., Hillier, S.G, and Spears, N. (2008). Follicular growth and oocyte competence in the in vitro cultured mouse follicle:effects of gonadotrophins and steroids. Molecular Hum Reprod 14,75-83.
Muruvi, W., Picton, H.M., Rodway, R.G, and Joyce, I.M. (2005). In vitro growth of oocytes from primordial follicles isolated from frozen-thawed lamb ovaries. Theriogenology 64,1357-1370.
Muruvi, W., Picton, H.M., Rodway, R.G, and Joyce, I.M. (2009). In vitro growth and differentiation of primary follicles isolated from cryopreserved sheep ovarian tissue. Anim Reprod Sci 112,36-50.
Muttukrishna, S., Tannetta, D., Groome, N., and Sargent, I. (2004). Activin and follistatin in female reproduction. Mol Cell Endocrinol 225,45-56.
Nation, A., and Selwood, L. (2009). The production of mature oocytes from adult ovaries following primary follicle culture in a marsupial. Reproduction 138,247-255.
Nayudu, P.L., Fehrenbach, A., Kiesel, P., Vitt, U.A., Pancharatna, K., and Osborn, S. (2001). Progress toward understanding follicle development in vitro:Appearances are not deceiving. Arch Med Res 32,587-594.
Nayudu, P.L., and Osborn, S.M. (1992). Factors influencing the rate of preantral and antral growth of mouse ovarian follicles invitro. J Reprod Fertil 95,349-362.
Neufeld, G, Ferrara, N., Schweigerer, L., Mitchell, R., and Gospodarowicz, D. (1987). Bovine granulosa cells produce basic fibroblast growth factor. Endocrinology 121,597-603.
Newton, H., and Illingworth, P. (2001). In-vitro growth of murine pre-antral follicles after isolation from cryopreserved ovarian tissue. Hum Reprod 16,423-429.
Newton, H., Picton, H., and Gosden, R.G (1999). In vitro growth of oocyte-granulosa cell complexes isolated from cryopreserved ovine tissue. J Reprod Fertil 115,141-150.
Nilsson, E.E., Kezele, P., and Skinner, M.K. (2002). Leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transition in rat ovaries. Mol Cell Endocrinol 188,65-73.
Nilsson, E.E., and Skinner, M.K. (2002). Growth and differentiation factor-9 stimulates progression of early primary but not primordial rat ovarian follicle development. Biol Reprod 67,1018-1024.
Nilsson, E.E., and Skinner, M.K. (2003). Bone morphogenetic protein-4 acts as an ovarian follicle survival factor and promotes primordial follicle development. Biol Reprod 69,1265-1272.
Nilsson, E.E., and Skinner, M.K. (2004). Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transition. Mol Cell Endocrinol 214,19-25.
Nogueira, D., Cortvrindt, R., Everaerdt, B., and Smitz, J. (2005). Effects of long-term in vitro exposure to phosphodiesterase type-3 inhibitors on follicle and oocyte development. Reproduction 130,177-186.
Nonowaki, S., Takahashi, K., and Horiuchi, T. (2010). Culture media affect follicle survival and oocyte maturation in preantral mouse follicle cultures. Journal of Mammalian Ova Research 27,35-41.
Nuttinck, F., Mermillod, P., Massip, A., and Dessy, F. (1993). Characterization of invitro growth of bovine preantral ovarian follicles-a preliminary-study. Theriogenology 39,811-821.
O'Brien, M.J., Pendola, J.K., and Eppig, J.J. (2003). A revised protocol for in vitro development of mouse oocytes from primordial follicles dramatically improves their developmental competence. Biol Reprod 68,1682-1686.
O'Donnell, K.A., Wentzel, E.A., Zeller, K.I., Dang, C.V., and Mendell, J.T. (2005). c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435,839-843.
Obata, Y., Kono, T., and Hatada, I. (2002). Oogenesis:Maturation of mouse fetal germ cells in vitro-Even immature oocytes can eventually be fertilized after some skilful manipulation. Nature 418,497-498.
Ohinata, Y., Ohta, H., Shigeta, M., Yamanaka, K., Wakayama, T., and Saitou, M. (2009). A signaling principle for the specification of the germ cell lineage in mice. Cell 137,571-584.
Oktay, K., Briggs, D., and Gosden, R.G (1997). Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles. J Clin Endocr Metab 82,3748-3751.
Oktay, K., Karlikaya, G., Akman, O., Ojakian, GK., and Oktay, M. (2000). Interaction of extracellular matrix and activin-A in the initiation of follicle growth in the mouse ovary. Biol Reprod 63,457-461.
Oktay, K., Newton, H., Mullan, J., and Gosden, R.G (1998). Development of human primordial follicles to antral stages in scid/hpg mice stimulated with follicle stimulating hormone. Hum Reprod 13,1133-1138.
Oktem, O., and Oktay, K. (2007). The role of extracellular matrix and activin-A in in vitro growth and survival of murine preantral follicles. Reprod Sci 14,358-366.
Otsuka, F., Moore, R.K., Iemura, S., Ueno, N., and Shimasaki, S. (2001). Follistatin inhibits the function of the oocyte-derived factor BMP-15. Biochem Biophys Res Commun 289,961-966.
Otsuka, F., Yao, Z.X., Lee, T.H., Yamamoto, S., Erickson, G.F., and Shimasaki, S. (2000). Bone morphogenetic protein-15-Identification of target cells and biological functions. J Biol Chem 275, 39523-39528.
Palter, S.F., Tavares, A.B., Hourvitz, A., Veldhuis, J.D., and Adashi, E.Y. (2001). Are estrogens of import to primate/human ovarian folliculogenesis? Endocr Rev 22,389-424.
Pangas, S.A., Saudye, H., Shea, L.D., and Woodruff, T.K. (2003). Novel approach for the three-dimensional culture of granulosa cell-oocyte complexes. Tissue Eng 9,1013-1021.
Park, S.M., Shell, S., Radjabi, A.R., Schickel, R., Feig, C., Boyerinas, B., Dinulescu, D.M., Lengyel, E., and Peter, M.E. (2007). Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle 6,2585-2590.
Pasquinelli, A.E., Reinhart, B.J., Slack, F., Martindale, M.Q., Kuroda, M.I., Maller, B., Hayward, D.C., Ball, E.E., Degnan, B., Muller, P., et al. (2000). Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408,86-89.
Pesty, A., Miyara, F., Debey, P., Lefevre, B., and Poirot, C. (2007). Multiparameter assessment of mouse oogenesis during follicular growth in vitro. Molecular Hum Reprod 13,3-9.
Picton, H.M., Danfour, M.A., Harris, S.E., Chambers, E.L., and Huntriss, J. (2003). Growth and maturation of oocytes in vitro. Reproduction (Cambridge, England) Supplement 61,445-462.
Picton, H.M., Harris, S.E., Muruvi, W., and Chambers, E.L. (2008). The in vitro growth and maturation of follicles. Reproduction 136,703-715.
Picton, H.M., Mkandla, A., Salha, O., Wynn, P., and Gosden, R.G. (1999). Initiation of human primordial follicle growth in vitro in ultrathin slices of ovarian cortex. Hum Reprod 14,11-11.
Qureshi, A.I., Nussey, S.S., Bano, G, Musonda, P., Whitehead, S.A., and Mason, H.D. (2008). Testosterone selectively increases primary follicles in ovarian cortex grafted onto embryonic chick membranes: relevance to polycystic ovaries. Reproduction 136,187-194.
Rajkovic, A. (2007). Genetics of ovarian failure and development. Semin Reprod Med 25,223-224.
Rajkovic, A., Pangas, S.A., Ballow, D., Suzumori, N., and Matzuk, M.M. (2004). NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science 305,1157-1159.
Rajpert-De Meyts, E., Jorgensen, N., Graem, N., Muller, J., Cate, R.L., and Skakkebaek, N.E. (1999). Expression of anti-Mullerian hormone during normal and pathological gonadal development: Association with differentiation of Sertoli and granulosa cells. J Clin Endocr Metab 84,3836-3844.
Rankin, T., Familari, M., Lee, E., Ginsberg, A., Dwyer, N., BlanchetteMackie, J., Drago, J., Westphal, H., and Dean, J. (1996). Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development 122,2903-2910.
Redding, G.P., Bronlund, J.E., and Hart, A.L. (2007). Mathematical modelling of oxygen transport-limited follicle growth. Reproduction 133,1095-1106.
Reddy, P., Liu, L., Adhikari, D., Jagarlamudi, K., Rajareddy, S., Shen, Y., Du, C., Tang, W., Hamalainen, T., Peng, S.L., et al. (2008). Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science 319,611-613.
Reinhart, B.J., Slack, F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E., Horvitz, H.R., and Ruvkun, G (2000). The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403,901-906.
Reinhart, B.J., Weinstein, E.G., Rhoades, M.W., Bartel, B., and Bartel, D.P. (2002). MicroRNAs in plants. Genes Dev 16,1616-1626.
Rhoades, M.W., Reinhart, B.J., Lim, L.P., Burge, C.B., Bartel, B., and Bartel, D.P. (2002). Prediction of plant microRNA targets. Cell 110,513-520.
Rice, S., Ojha, K., and Mason, H. (2008). Human ovarian biopsies as a viable source of pre-antral follicles. Hum Reprod 23,600-605.
Richard, F.J., and Sirard, M.A. (1996). Effects of follicular cells on oocyte maturation.2. Theca cell inhibition of bovine oocyte maturation in vitro. Biol Reprod 54,22-28.
Richards, J.S. (1980). Maturation of ovarian follicles:actions and interactions of pituitary and ovarian hormones on follicular cell differentiation. Physiol Rev 60,51-89.
Richards, J.S., Jonassen, J.A., Rolfes, A.I., Kersey, K., and Reichert, L.E. (1979). Adenosine 3', 5'-monophosphate, luteinizing hormone receptor, and progesterone during granulosa cell differentiation: effects of estradiol and follicle-stimulating hormone. Endocrinology 104,765-773.
Rico, C., Fabre, S., Medigue, C., Di Clemente, N., Clement, F., Bontoux, M., Touze, J.-L., Dupont, M., Briant, E., and Remy, B. (2009). Anti-mtlllerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow. Biol Reprod 80,50-59.
Roberts, R., Franks, S., and Hardy, K. (2002). Culture environment modulates maturation and metabolism of human oocytes. Hum Reprod 17,2950-2956.
Robker, R.L., and Richards, J.S. (1998). Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1. Mol Endocrinol 12,924-940.
Rodriguez, A., Griffiths-Jones, S., Ashurst, J.L., and Bradley, A. (2004). Identification of mammalian microRNA host genes and transcription units. Genome Res 14,1902-1910.
Rose, U.M., Hanssen, R., and Kloosterboer, H.J. (1999). Development and characterization of an in vitro ovulation model using mouse ovarian follicles. Biol Reprod 61,503-511.
Rosenfeld, N., Aharonov, R., Meiri, E., Rosenwald, S., Spector, Y, Zepeniuk, M., Benjamin, H., Shabes, N., Tabak, S., Levy, A., et al. (2008). MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol 26,462-469.
Rowghani, N.M., Heise, M.K., McKeel, D., McGee, E.A., Koepsel, R.R., and Russell, A.J. (2004). Maintenance of morphology and growth of ovarian follicles in suspension culture. Tissue Eng 10, 545-552.
Roy, S.K., and Kole, A.R. (1998). Ovarian transforming growth factor-beta (TGF-beta) receptors:in-vitro effects of follicle stimulating hormone, epidermal growth factor and TGF-beta on receptor expression in human preantral follicles. Molecular Hum Reprod 4,207-214.
Roy, S.K., and Treacy, B.J. (1993). Isolation and long-term culture of human preantral follicles. Fertil Steril 59,783-790.
Sadatsuki, M., Tsutsumi, O., Yamada, R., Muramatsu, M., and Taketani, Y. (1993). Local regulatory effects of activin-a and follistatin on meiotic maturation of rat oocytes. Biochem Biophys Res Commun 196, 388-395.
Sagirkaya, H., Misirlioglu, M., Kaya, A., First, N.L., Parrish, J.J., and Memili, E. (2007). Developmental potential of bovine oocytes cultured in different maturation and culture conditions. Anim Reprod Sci 101,225-240.
Saha, S., Shimizu, M., Geshi, M., and Izaike, Y. (2000a). In vitro culture of bovine preantral follicles. Anim Reprod Sci 63,27-39.
Saha, S., Shimizu, M., Geshi, M., and Izaike, Y. (2000b). In vitro culture of bovine preantral follicles. Anim Reprod Sci 63,27-39.
Saha, S., Shimizu, M., Geshi, M., and Izaike, Y. (2002). Comparison of enzymatic and mechanical methods for the collection of bovine preantral follicles. J Anim Sci 74,155-161.
Saha, S., Shimizu, M., and Izaike, Y (1999). In vitro culture and characterization of bovine preantral follicles (PAF). Theriogenology 51,308.
Saitou, M., Barton, S.C., and Surani, M.A. (2002). A molecular programme for the specification of germ cell fate in mice. Nature 418,293-300.
Santos, M.A., Kuijk, E.W., and Macklon, N.S. (2010). The impact of ovarian stimulation for IVF on the developing embryo. Reproduction 139,23-34.
Saragueta, P.E., Lanuza, G.M., and Baranao, J.L. (2002). Autocrine role of transforming growth factor beta 1 on rat granulosa cell proliferation. Biol Reprod 66,1862-1868.
SASSON, R., DANTES, A., TAJIMA, K., and AMSTERDAM, A. (2003). Novel genes modulated by FSH in normal and immortalized FSH-responsive cells:new insights into the mechanism of FSH action. FASEB J 17,1256-1266.
Schier, A.F. (2007). The maternal-zygotic transition:death and birth of RNAs. Science 316,406-407.
Schwarz, D.S., Hutvagner, G., Du, T., Xu, Z., Aronin, N., and Zamore, P.D. (2003). Asymmetry in the assembly of the RNAi enzyme complex. Cell 115,199-208.
Scott, J.E., Zhang, P., and Hovatta, O. (2004). Benefits of 8-bromo-guanosine 3',5'-cyclic monophosphate (8-br-cGMP) in human ovarian cortical tissue culture. Reprod Biomed Online 8,319-324.
Sen, A., and Hammes, S.R. (2010). Granulosa Cell-Specific Androgen Receptors Are Critical Regulators of Ovarian Development and Function. Mol Endocrinol 24,1393-1403.
Senbon, S., and Miyano, T. (2002). Bovine oocytes in early antral follicles grow in serum-free media:effect of hypoxanthine on follicular morphology and oocyte growth. Zygote 10,301-309.
Shaywitz, A.J., and Greenberg, M.E. (1999). CREB:a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68,821-861.
Shimasaki, S., Moore, R.K., Otsuka, F., and Erickson, GF. (2004). The bone morphogenetic protein system in mammalian reproduction. Endocr Rev 25,72-101.
Shimasaki, S., Zachow, R.J., Li, D.M., Kim, H., Iemura, S., Ueno, N., Sampath, K., Chang, R.J., and Erickson, GF. (1999). A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci USA96,7282-7287.
Shuttleworth, G, Pipkin, F.B., and Hunter, M.G (2002). In vitro development of pig preantral follicles cultured in a serum-free medium and the effect of angiotensin II. Reproduction 123,807-818.
Silva, C.C., Groome, N.P., and Knight, P.G. (1999). Demonstration of a suppressive effect of inhibin alpha-subunit on the developmental competence of in vitro matured bovine oocytes. J Reprod Fertil 115,381-388.
Simon, A.M., Goodenough, D.A., Li, E., and Paul, D.L. (1997). Female infertility in mice lacking connexin 37. Nature 385,525-529.
Sirotkin, A.V., Laukova, M., Ovcharenko, D., Brenaut, P., and MLyncek, M. (2010). Identification of microRNAs controlling human ovarian cell proliferation and apoptosis. J Cell Physiol 223,49-56.
Sirotkin, A.V., Ovcharenko, D., Grossmann, R., Laukova, M., and MLyntek, M. (2009). Identification of MicroRNAs Controlling Human Ovarian Cell Steroidogenesis Via a Genome-Scale Screen. J Cell Physiol 219,415-420.
Skinner, M.K. (2005). Regulation of primordial follicle assembly and development. Hum Reprod Update 11, 461-471.
Smitz, J., and Cortvrindt, R. (1998). Follicle culture after ovarian cryostorage. Maturitas 30,171-179.
Smitz, J., Cortvrindt, R., Hu, Y.X., and Vanderstichele, H. (1998). Effects of recombinant activin A on in vitro culture of mouse preantral follicles. Mol Reprod Dev 50,294-304.
Smitz, J., Cortvrindt, R., and vanSteirteghem, A.C. (1996). Normal oxygen atmosphere is essential for the solitary long-term culture of early preantral mouse follicles. Mol Reprod Dev 45,466-475.
Smitz, J., Dolmans, M.M., Donnez, J., Fortune, J.E., Hovatta, O., Jewgenow, K., Picton, H.M., Plancha, C., Shea, L.D., Stouffer, R.L., et al. (2010). Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation:implications for fertility preservation. Hum Reprod Update 16,395-414.
Solloway, M.J., Dudley, A.T., Bikoff, E.K., Lyons, K.M., Hogan, B.L.M., and Robertson, E.J. (1998). Mice lacking Bmp6 function. Dev Genet 22,321-339.
Spears, N., Boland, N.I., Murray, A.A., and Gosden, R.G. (1994). Mouse oocytes derived from in-vitro grown primary ovarian follicles are fertile. Hum Reprod 9,527-532.
Spears, N., Murray, A.A., Allison, V., Boland, N.I., and Gosden, R.G. (1998). Role of gonadotrophins and ovarian steroids in the development of mouse follicles in vitro. J Reprod Fertil 113,19-26.
Spicer, L.J., Aad, P.Y., Allen, D.T., Mazerbourg, S., Payne, A.H., and Hsueh, A.J. (2008). Growth differentiation factor 9 (GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells:influence of follicle size on responses to GDF9. Biol Reprod 78,243-253.
Stitzel, M.L., and Seydoux, G. (2007). Regulation of the oocyte-to-zygote transition. Science 316,407-408.
Su, Y.Q., Sugiura, K., Woo, Y., Wigglesworth, K., Kamdar, S., Affourtit, J., and Eppig, J.J. (2007). Selective degradation of transcripts during meiotic maturation of mouse oocytes. Dev Biol 302,104-117.
Tang, F., Kaneda, M., O'Carroll, D., Hajkova, P., Barton, S.C., Sun, YA., Lee, C., Tarakhovsky, A., Lao, K., and Surani, M.A. (2007). Maternal microRNAs are essential for mouse zygotic development. Genes Dev 21,644-648.
Taylor, D.D., and Gercel-Taylor, C. (2008). MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 110,13-21.
Telfer, E., Webb, R., Moor, R., and Gosden, R. (1999). New approaches to increasing oocyte yield from ruminants. J Anim Sci 68.
Telfer, E.E. (1996). The development of methods for isolation and culture of preantral follicles from bovine and porcine ovaries. Theriogenology 45,101-110.
Telfer, E.E., Binnie, J.P., McCaffery, F.H., and Campbell, B.K. (2000). In vitro development of oocytes from porcine and bovine primary follicles. Mol Cell Endocrinol 163,117-123.
Telfer, E.E., McLaughlin, M., Ding, C., and Thong, K.J. (2008). A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin. Hum Reprod 23,1151-1158.
Thomas, F.H., Campbell, B.K., Armstrong, D.G, and Telfer, E.E. (2007). Effects of IGF-I bioavailability on bovine preantral follicular development in vitro. Reproduction 133,1121-1128.
Thomas, F.H., Ismail, R.S., Jiang, J.-Y., and Vanderhyden, B.C. (2008). Kit ligand 2 promotes murine oocyte growth in vitro. Biol Reprod 78,167-175.
Thomas, F.H., Leask, R., Srsen, V., Riley, S.C., Spears, N., and Telfer, E.E. (2001). Effect of ascorbic acid on health and morphology of bovine preantral follicles during long-term culture. Reproduction 122, 487-495.
Tilly, J.L., and Tilly, K.I. (1995). Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles. Endocrinology 136,242-252.
Tomic, D., Miller, K.P., Kenny, H.A., Woodruff, T.K., Hoyer, P., and Flaws, J.A. (2004). Ovarian follicle development requires Smad3. Mol Endocrinol 18,2224-2240.
Tonetta, S.A., and diZerega, G.S. (1989). Intragonadal regulation of follicular maturation. Endocr Rev 10, 205-229.
Van den Hurk, R., Bevers, M., and Beckers, J.-F. (1997). In-vivo and in-vitro development of preantral follicles. Theriogenology 47,73-82.
van Rooij, I.A.J., Broekmans, F.J.M., te Velde, E.R., Fauser, B., Bancsi, L., de Jong, F.H., and Themmen, A.P.N. (2002). Serum anti-Mullerian hormone levels:a novel measure of ovarian reserve. Hum Reprod 17,3065-3071.
van Wagtendonk-de Leeuw, A.M., Mullaart, E., de Roos, A.P.W., Merton, J.S., den Daas, J.H.G., Kemp, B., and de Ruigh, L. (2000). Effects of different reproduction techniques:AI, MOET or IVP, on health and welfare of bovine offspring. Theriogenology 53,575-597.
Vanderhyden, B., Cohen, J., and Morley, P. (1993). Mouse oocytes regulate granulosa cell steroidogenesis. Endocrinology 133,423-426.
Vanderhyden, B.C., and Macdonald, E.A. (1998). Mouse oocytes regulate granulosa cell steroidogenesis throughout follicular development. Biol Reprod 59,1296-1301.
Vassena, R., Schramm, R.D., and Latham, K.E. (2005). Species-dependent expression patterns of DNA methyltransferase genes in mammalian oocytes and preimplantation embryos. Mol Reprod Dev 72, 430-436.
Visser, J.A., de Jong, F.H., Laven, J.S., and Themmen, A.P. (2006). Anti-Mullerian hormone:a new marker for ovarian function. Reproduction 131,1-9.
Visser, J.A., and Themmen, A.P.N. (2005). Anti-Mullerian hormone and folliculogenesis. Mol Cell Endocrinol 234,81-86.
Vitt, U.A., Hayashi, M., Klein, C., and Hsueh, A.J.W. (2000a). Growth differentiation factor-9 stimulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulosa cells from small antral and preovulatory rat follicles. Biol Reprod 62,370-377.
Vitt, U.A., McGee, E.A., Hayashi, M., and Hsueh, A.J.W. (2000b). In vivo treatment with GDF-9 stimulates primordial and primary follicle progression and theca cell marker CYP17 in ovaries of immature rats. Endocrinology 141,3814-3820.
W-S, O., Robertson, D., and De Kretser, D. (1989). Inhibin as an oocyte meiotic inhibitor. Mol Cell Endocrinol 62,307-311.
Walters, K.A., Allan, C.M., and Handelsman, D.J. (2008). Androgen actions and the ovary. Biol Reprod 78, 380-389.
Walters, K.A., Binnie, J.P., Campbell, B.K., Armstrong, D.G, and Telfer, E.E. (2006). The effects of IGF-I on bovine follicle development and IGFBP-2 expression are dose and stage dependent. Reproduction 131, 515-523.
Wandji, S.A., Srsen, V., Nathanielsz, P.W., Eppig, J.J., and Fortune, J.E. (1997). Initiation of growth of baboon primordial follicles in vitro. Hum Reprod 12,1993-2001.
Wandji, S.A., Srsen, V., Voss, A.K., Eppig, J.J., and Fortune, J.E. (1996). Initiation in vitro of growth of bovine primordial follicles. Biol Reprod 55,942-948.
Wang, J.R., and Roy, S.K. (2004). Growth differentiation factor-9 and stem cell factor promote primordial follicle formation in the hamster:Modulation by follicle-stimulating hormone. Biol Reprod 70,577-585.
Wassarman, P.M., Josefowicz, W.J., and Letourneau, GE. (1976). Meiotic maturation of mouse oocytes invitro-inhibition of maturation at specific stages of nuclear progression. J Cell Sci 22,531-545.
Watanabe, T., Takeda, A., Tsukiyama, T., Mise, K., Okuno, T., Sasaki, H., Minami, N., and Imai, H. (2006). Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev 20, 1732-1743.
Weaver, V.M., Fischer, A.H., Peterson, O.W., and Bissell, M.J. (1996). The importance of the microenvironment in breast cancer progression:recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochem Cell Biol 74,833-851.
Webber, L.J., Stubbs, S.A., Stark, J., Margara, R.A., Trew, GH., Lavery, S.A., Hardy, K., and Franks, S. (2007). Prolonged survival in culture of preantral follicles from polycystic ovaries. J Clin Endocr Metab 92,1975-1978.
Weenen, C, Laven, J.S.E., von Bergh, A.R.M., Cranfield, M., Groome, N.P., Visser, J.A., Kramer, P., Fauser, B., and Themmen, A.P.N. (2004). Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Molecular Hum Reprod 10,77-83.
West, E.R., Xu, M., Woodruff, T.K., and Shea, L.D. (2007). Physical properties of alginate hydrogels and their effects on in vitro follicle development. Biomaterials 28,4439-4448.
Wightman, B., Ha, I., and Ruvkun, G. (1993). Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75,855-862.
Williams, A.H., Liu, N., van Rooij, E., and Olson, E.N. (2009). MicroRNA control of muscle development and disease. Curr Opin Cell Biol 21,461-469.
Wood, J.R., Dumesic, D.A., Abbott, D.H., and Strauss, J.F.,3rd (2007). Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab 92,705-713.
Wright, C.S., Hovatta, O., Margara, R., Trew, G, Winston, R.M.L., Franks, S., and Hardy, K. (1999). Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles. Hum Reprod 14,1555-1562.
Wu, J., Emery, B.R., and Carrell, D.T. (2001). In vitro growth, maturation, fertilization, and embryonic development of oocytes from porcine preantral follicles. Biol Reprod 64,375-381.
Wycherley, G, Downey, D., Kane, M.T., and Hynes, A.C. (2004). A novel follicle culture system markedly increases follicle volume, cell number and oestradiol secretion. Reproduction 127,669-677.
Xiao, S., Robertson, D.M., and Findlay, J.K. (1992). Effects of activin and follicle-stimulating-hormone (fsh)-suppressing protein follistatin on fsh receptors and differentiation of cultured rat granulosa-cells. Endocrinology 131,1009-1016.
Xu, M., West, E., Shea, L.D., and Woodruff, T.K. (2006). Identification of a stage-specific permissive in vitro culture environment for follicle growth and oocyte development. Biol Reprod 75,916-923.
Xu, S., Linher-Melville, K., Yang, B.B., Wu, D., and Li, J. (2011). Micro-RNA378 (miR-378) regulates ovarian estradiol production by targeting aromatase. Endocrinology 152,3941-3951.
Yamoto, M., Minami, S., Nakano, R., and Kobayashi, M. (1992). Immunohistochemical localization of inhibin activin subunits in human ovarian follicles during the menstrual-cycle. J Clin Endocr Metab 74, 989-993.
Yan, C.N., Wang, P., DeMayo, J., DeMayo, F.J., Elvin, J.A., Carino, C., Prasad, S.V., Skinner, S.S., Dunbar, B.S., Dube, J.L., et al. (2001). Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol 15,854-866.
Yan, W., Morozumi, K., Zhang, J., Ro, S., Park, C., and Yanagimachi, R. (2008). Birth of mice after intracytoplasmic injection of single purified sperm nuclei and detection of messenger RNAs and MicroRNAs in the sperm nuclei. Biol Reprod 78,896-902.
Yang, X., Kubota, C., Suzuki, H., Taneja, M., Bols, P.E., and Presicce, G.A. (1998). Control of oocyte maturation in cows--biological factors. Theriogenology 49,471-482.
Yang, Y.Z., Balla, A., Danilovich, N., and Sairam, M.R. (2003). Developmental and molecular aberrations associated with deterioration of oogenesis during complete or partial follicle-stimulating hormone receptor deficiency in mice. Biol Reprod 69,1294-1302.
Yao, G, Yin, M., Lian, J., Tian, H., Liu, L., Li, X., and Sun, F. (2010). MicroRNA-224 Is Involved in Transforming Growth Factor-beta-Mediated Mouse Granulosa Cell Proliferation and Granulosa Cell Function by Targeting Smad4. Mol Endocrinol 24,540-551.
Yin, M., Lu, M., Yao, G, Tian, H., Lian, J., Liu, L., Liang, M., Wang, Y, and Sun, F. (2012). Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by targeting RBMS1. Mol Endocrinol 26,1129-1143.
Ying, Y., Qi, X.X., and Zhao, GQ. (2001). Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways. Proc Natl Acad Sci U S A 98,7858-7862.
Ying, Y, and Zhao, G.Q. (2001). Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. Dev Biol 232,484-492.
Young, L.E., Sinclair, K.D., and Wilmut, I. (1998). Large offspring syndrome in cattle and sheep. Rev Reprod 3,155-163.
Yu, N., and Roy, S.K. (1999). Development of primordial and prenatal follicles from undifferentiated somatic cells and oocytes in the hamster prenatal ovary in vitro:Effect of insulin. Biol Reprod 61,1558-1567.
Zeng, Y., and Cullen, B.R. (2003). Sequence requirements for micro RNA processing and function in human cells. RNA 9,112-123.
Zeng, Y., and Cullen, B.R. (2004). Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res 32,4776-4785.
Zeng, Y., Wagner, E.J., and Cullen, B.R. (2002). Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell 9,1327-1333.
Zeng, Y., Yi, R., and Cullen, B.R. (2003). MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci U S A100,9779-9784.
Zhao, J., Dorland, M., Taverne, M.A.M., Van der Weijden, G.C., Bevers, M.M., and Van den Hurk, R. (2000). In vitro culture of rat pre-antral follicles with emphasis on follicular interactions. Mol Reprod Dev 55, 65-74.
Zhao, J., Taverne, M.A.M., van der Weijden, G.C., Bevers, M.M., and van den Hurk, R. (2001). Effect of activin A on in vitro development of rat preantral follicles and localization of activin A and activin receptor Ⅱ. Biol Reprod 65,967-977.
Zhou, H.M., and Zhang, Y. (2005). Effect of growth factors on in vitro development of caprine preantral follicle oocytes. Anim Reprod Sci 90,265-272.
Zhou, Y., Zhu, Y., Zhang, S., Wang, H., Wang, S., and Yang, X. (2011). MicroRNA expression profiles in premature ovarian failure patients and its potential regulate functions. Chinese journal of birth health and heredity 19,20-22.