温肾壮督、散寒活血中药内外合用治疗强直性脊柱炎肾虚督寒证的临床研究
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摘要
研究目的
本研究旨在探讨温肾壮督、散寒活血中药内外合用治疗强直性脊柱炎肾虚督寒证的临床疗效、安全性及不良反应,通过设立对照组,进行治疗前后比较及组间横向比较,以进一步探索中医药治疗强直性脊柱炎安全有效的方法。
研究方法
将40例符合纳入标准的强直性脊柱炎肾虚督寒证患者随机分为两组,治疗组20例,给予常规治疗+柳氮磺胺吡啶片+中药熏蒸配合温肾壮督,散寒活血中药水煎剂；对照组20例,给予常规治疗+柳氮磺吡啶片,制定观察表,通过对患者体征的改善情况、BASDAI、BASFI评分及ESR、CRP、血流变等的测定,并采用国际ASAS工作组制定的ASAS20、BASDAI50标准及中医证候疗效标准,评价温肾壮督、散寒活血中药内外合用治疗强直性脊柱炎的疗效。
研究结果
通过对40例患者12周的观察,温肾壮督、散寒活血中药内外合用在Bath病情活动指数、Bath功能指数、疼痛、炎症指数等临床症状有明显的改善(P<0.05), ESR、CRP和血流变指标亦有明显改善(P<0.05),治疗组疗效优于对照组。
结论
温肾壮督、散寒活血中药内外合用治疗强直性脊柱炎肾虚督寒证在改善患者症状体征,提高生活质量,减轻疾病活动性等方面都具有良好的疗效,安全性及依从性好,具有广阔的应用前景。
Objective
This research is for the purpose of discussing warming-invigorating kidney and stringing ridge,dispelling cold and activating blood circulation for treatment conbined with external and internal chinese herbs of kidney deficiency and cold in governor vessel of ankylosing spondylitis the clinical effectiveness,the drug safety and adverse reactions.By setting the control group,crosswise comparing on the effectiveness by contrasting with the treatment group in order to explore the chinese medicine in treating the ankylosing spondylitis safely and effectively.
Methods
Conforming to the ankylosing spondylitis kidney deficiency and cold in governor vessel patients who 40 examples integrates the standard to divide into two groups stochastically.The treatment group of 20 examples,gives conventional treatment and sulfasalazine and chinese medicine fumigating conbined with decoction of warming-invigorating kidney and stringing ridge,dispelling cold and activating blood circulation.The control group of 20 examples,give conventional treatment and sulfasalazine,and formulate observation table.Through patient symptom improved situation,the Bath disease activity index (BASDAI),Bath functional index (BASFI) and to routine blood test,ESR,CRP,hemorheologic test and so on,and Adopting the ASAS20 and BASDAI50 standards developed by international ASAS Working Group and efficiency of TCM syndromes criteria to evaluate the efficiency of chinese medicine conbined external and internal treatment of AS.
Results
Through to 40 example patients of 12 week-long observations the chinese medicine conbined external and internal of warming-invigorating kidney and stringing ridge,dispelling cold and activating blood circulation to improve the patient's symptom,the Bath disease activity index(BASDAI),Bath functional index(BASFI),pain,inflammation index and clinical symptoms have shown obvious improvement(P<0.05),ESR,CRP and hemorheologic test were also improved(P<0.05). The treatment group's clinical symptoms improved significantly.
Conclusion
warming-invigorating kidney and stringing ridge,dispelling cold and activating blood circulation for treatment conbined external and internal chinese herbs of kidney deficiency and cold in governor vessel of ankylosing spondylitis,regardless of improving the patient symptom,enhanceing life,reduceing the disease activity to have the good curative effect,and its security and the compliance is good,which has certain utilization prospect.
本研究旨在探讨温肾壮督、散寒活血中药内外合用治疗强直性脊柱炎肾虚督寒证的临床疗效、安全性及不良反应,通过设立对照组,进行治疗前后比较及组间横向比较,以进一步探索中医药治疗强直性脊柱炎安全有效的方法。
研究方法
将40例符合纳入标准的强直性脊柱炎肾虚督寒证患者随机分为两组,治疗组20例,给予常规治疗+柳氮磺胺吡啶片+中药熏蒸配合温肾壮督,散寒活血中药水煎剂；对照组20例,给予常规治疗+柳氮磺吡啶片,制定观察表,通过对患者体征的改善情况、BASDAI、BASFI评分及ESR、CRP、血流变等的测定,并采用国际ASAS工作组制定的ASAS20、BASDAI50标准及中医证候疗效标准,评价温肾壮督、散寒活血中药内外合用治疗强直性脊柱炎的疗效。
研究结果
通过对40例患者12周的观察,温肾壮督、散寒活血中药内外合用在Bath病情活动指数、Bath功能指数、疼痛、炎症指数等临床症状有明显的改善(P<0.05), ESR、CRP和血流变指标亦有明显改善(P<0.05),治疗组疗效优于对照组。
结论
温肾壮督、散寒活血中药内外合用治疗强直性脊柱炎肾虚督寒证在改善患者症状体征,提高生活质量,减轻疾病活动性等方面都具有良好的疗效,安全性及依从性好,具有广阔的应用前景。
Objective
This research is for the purpose of discussing warming-invigorating kidney and stringing ridge,dispelling cold and activating blood circulation for treatment conbined with external and internal chinese herbs of kidney deficiency and cold in governor vessel of ankylosing spondylitis the clinical effectiveness,the drug safety and adverse reactions.By setting the control group,crosswise comparing on the effectiveness by contrasting with the treatment group in order to explore the chinese medicine in treating the ankylosing spondylitis safely and effectively.
Methods
Conforming to the ankylosing spondylitis kidney deficiency and cold in governor vessel patients who 40 examples integrates the standard to divide into two groups stochastically.The treatment group of 20 examples,gives conventional treatment and sulfasalazine and chinese medicine fumigating conbined with decoction of warming-invigorating kidney and stringing ridge,dispelling cold and activating blood circulation.The control group of 20 examples,give conventional treatment and sulfasalazine,and formulate observation table.Through patient symptom improved situation,the Bath disease activity index (BASDAI),Bath functional index (BASFI) and to routine blood test,ESR,CRP,hemorheologic test and so on,and Adopting the ASAS20 and BASDAI50 standards developed by international ASAS Working Group and efficiency of TCM syndromes criteria to evaluate the efficiency of chinese medicine conbined external and internal treatment of AS.
Results
Through to 40 example patients of 12 week-long observations the chinese medicine conbined external and internal of warming-invigorating kidney and stringing ridge,dispelling cold and activating blood circulation to improve the patient's symptom,the Bath disease activity index(BASDAI),Bath functional index(BASFI),pain,inflammation index and clinical symptoms have shown obvious improvement(P<0.05),ESR,CRP and hemorheologic test were also improved(P<0.05). The treatment group's clinical symptoms improved significantly.
Conclusion
warming-invigorating kidney and stringing ridge,dispelling cold and activating blood circulation for treatment conbined external and internal chinese herbs of kidney deficiency and cold in governor vessel of ankylosing spondylitis,regardless of improving the patient symptom,enhanceing life,reduceing the disease activity to have the good curative effect,and its security and the compliance is good,which has certain utilization prospect.
引文
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