安痔消炎片的药效学研究
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摘要
痔疮是肛肠科最常见的疾病,任何年龄均可发生,其中以20——40岁人群多见,并随着年龄的增加症状逐渐加重,至70岁以后才有下降趋势,男女发生率无差异。痔疮的病因有诱因和惹因,诱因包括遗传、年龄、风俗、习惯、气候、妊娠、生理禀赋、消化道疾患等;惹因包括滥用泻药、食物及便秘等。痔疮的表现呈多样化的形式,而出血、脱垂、疼痛、嵌顿等症状是其主要的表现形式。
关于痔病的治疗,大致可分为保守疗法和手术方法两种,各有其适应证。痔疮患者由于长期处于疼痛的折磨下,对于手术的治疗方法普遍有恐惧心理,所以保守治疗往往是广大痔疮患者的选择。近年来,随着医学技术的飞速发展和解剖学理论研究的进一步深入,对痔疾病本身及其治疗方法的研究正逐步深入。在痔病的保守治疗方面,各种形式的药物相继出现,而现在痔疮药在市场上销售及患者对药物的选择、应用比较混乱,盲目性很大,所以治疗效果也不尽如人意。因而对于痔疮的研究和治疗是一项很有意义的工作。
本文旨在通过不同的动物模型,观察安痔消炎片在抗炎、镇痛、止血方面的疗效。而研究治疗痔疮药物的难点在于痔疮为直立行走的人类所特有,由于其解剖、生理的原因,难于用四肢行走的动物复制模拟人类痔疮的理想模型。因此痔疮在药效学上没有固定的动物模型,我们根据痔疮临床症状即疼痛、红肿、出血,应用抗炎、镇痛、止血、抗肛门溃疡的实验方法证明其药效学。在抗炎方面,采用小鼠耳廓肿胀法、腹腔毛细血管通透性法和大鼠足肿胀法,结果表明安痔消炎片能明显改善小鼠的耳廓局部血液循环,对二甲苯诱发的急性炎症有明显的抗炎消肿作用,能够明显降低醋酸引起的腹腔通透性的增高亢进,对蛋清致大鼠足肿胀有明显的抑制作用。在镇痛方面,采用热板法和扭体法,结果表明安痔消炎片没有提高小鼠对热刺激耐受性,不能够提高小鼠的痛阈值,而对醋酸引起的疼痛有抑制作用,能明显的降低小鼠的扭体次数。在止血方面,采用断尾法、毛细玻璃管法及玻片法证明有明显的止血、凝血作用。对醋酸所致的大鼠肛门溃疡,安痔消炎片能够减少大鼠的肛门的渗出及促进大鼠肛门溃疡的愈合。本实验通过对安痔消炎片的动物实验研究为临床用药提供重要的依据。
Hemorrhoids is the most common disease,Any age may occur,20 of them to a 40-year-old crowd Most of the increase,with age and symptoms gradually worsened,to 70-year-old only after the downward trend,There is no difference between men and women.Hemorrhoids are the cause of incentives and due Anger,Incentive including genetics,age,customs,habits,climate,pregnancy,Physiologicalendowment,gastrointestinal d-disorders;Positions for laxaive abuse, such as food and constipation.Hemorrhoids performance was in the form of diversification and bleeding, prolapse, pain and other symptoms incarcerated is the main form of expression.
On the treatment of hemorrhoids, Hemorrhoids can be broadly classified into two types Conservative therapy and surgical methods, Each has its own indications.Hemorrhoids patients in pain due to the long suffering, Surgical treatment for a general fear Therefore conservative treatment is often overwhelming majority of patients with hemorrhoids choice. In recent years, with the rapid development of medical technology and anatomy further theoretical studies on the treatment of hemorrhoid disease itself and its methods of research is gradually deepening. in the conservative treatment of hemorrhoids, Various forms of drug appeared one after another.Now hemorrhoids drugs on the market and sales of the drug in patients with the choice of confusion, blindness great, Therefore, treatment is unsatisfactory. Thus, for the research and treatment of hemorrhoids is a very significant work.
The paper through different animal model, Observer the Anzhi anti-inflammatory tablets in anti-inflammatory, analgesic, and the hemostatic effect. Research on treatment of hemorrhoids and the drug is difficult to walk upright hemorrhoids unique human, Because of its anatomy and physiology of reasons, Difficult to walk with the animals limbs copy of hemorrhoids to simulate human pathology model.Therefore,hemorrhoids in the pharmacodynamics of no fixed on the animal model, According to hemorrhoids clinical symptoms of pain, swelling, bleeding, Application of anti-inflammatory, analgesic, to stop bleeding, anti-ulcer anal experimental methods prove the Pharmacodynamics. Using mice ear edema, abdominal vascular permeability law and swelling of feet,The results show that anti-inflammatory tablets Anzhi mice can significantly improve the auricle local blood circulation, Of xylene-induced acute inflammation has obvious anti-inflammatory swelling, Acetate can significantly reduce the peritoneal permeability caused by the increase of hyperthyroidism, Of the egg white rat paw edema can be inhibited. in analgesia,Using hot plate and writhing law,The results show that anti-inflammatory tablets Anzhi mice did not increase the thermal resistance of mice can not increase the pain threshold, On the pain caused by acetic acid, it has inhibitinon significantly and reduced the number of mice writhing. In hemostasis, By Duan Wei, capillary glass tube slide of law and prove that there are obvious bleeding, clotting effect.Of acetic acid-induced ulcer in the anus ,Anzhi anti-inflammatory tablets t can reduce the leakage of the anus and promote the anal ulcer healing. Through this experimental anti-inflammatory tablets Anzhi animals for clinical drug research provides an important basis.
关于痔病的治疗,大致可分为保守疗法和手术方法两种,各有其适应证。痔疮患者由于长期处于疼痛的折磨下,对于手术的治疗方法普遍有恐惧心理,所以保守治疗往往是广大痔疮患者的选择。近年来,随着医学技术的飞速发展和解剖学理论研究的进一步深入,对痔疾病本身及其治疗方法的研究正逐步深入。在痔病的保守治疗方面,各种形式的药物相继出现,而现在痔疮药在市场上销售及患者对药物的选择、应用比较混乱,盲目性很大,所以治疗效果也不尽如人意。因而对于痔疮的研究和治疗是一项很有意义的工作。
本文旨在通过不同的动物模型,观察安痔消炎片在抗炎、镇痛、止血方面的疗效。而研究治疗痔疮药物的难点在于痔疮为直立行走的人类所特有,由于其解剖、生理的原因,难于用四肢行走的动物复制模拟人类痔疮的理想模型。因此痔疮在药效学上没有固定的动物模型,我们根据痔疮临床症状即疼痛、红肿、出血,应用抗炎、镇痛、止血、抗肛门溃疡的实验方法证明其药效学。在抗炎方面,采用小鼠耳廓肿胀法、腹腔毛细血管通透性法和大鼠足肿胀法,结果表明安痔消炎片能明显改善小鼠的耳廓局部血液循环,对二甲苯诱发的急性炎症有明显的抗炎消肿作用,能够明显降低醋酸引起的腹腔通透性的增高亢进,对蛋清致大鼠足肿胀有明显的抑制作用。在镇痛方面,采用热板法和扭体法,结果表明安痔消炎片没有提高小鼠对热刺激耐受性,不能够提高小鼠的痛阈值,而对醋酸引起的疼痛有抑制作用,能明显的降低小鼠的扭体次数。在止血方面,采用断尾法、毛细玻璃管法及玻片法证明有明显的止血、凝血作用。对醋酸所致的大鼠肛门溃疡,安痔消炎片能够减少大鼠的肛门的渗出及促进大鼠肛门溃疡的愈合。本实验通过对安痔消炎片的动物实验研究为临床用药提供重要的依据。
Hemorrhoids is the most common disease,Any age may occur,20 of them to a 40-year-old crowd Most of the increase,with age and symptoms gradually worsened,to 70-year-old only after the downward trend,There is no difference between men and women.Hemorrhoids are the cause of incentives and due Anger,Incentive including genetics,age,customs,habits,climate,pregnancy,Physiologicalendowment,gastrointestinal d-disorders;Positions for laxaive abuse, such as food and constipation.Hemorrhoids performance was in the form of diversification and bleeding, prolapse, pain and other symptoms incarcerated is the main form of expression.
On the treatment of hemorrhoids, Hemorrhoids can be broadly classified into two types Conservative therapy and surgical methods, Each has its own indications.Hemorrhoids patients in pain due to the long suffering, Surgical treatment for a general fear Therefore conservative treatment is often overwhelming majority of patients with hemorrhoids choice. In recent years, with the rapid development of medical technology and anatomy further theoretical studies on the treatment of hemorrhoid disease itself and its methods of research is gradually deepening. in the conservative treatment of hemorrhoids, Various forms of drug appeared one after another.Now hemorrhoids drugs on the market and sales of the drug in patients with the choice of confusion, blindness great, Therefore, treatment is unsatisfactory. Thus, for the research and treatment of hemorrhoids is a very significant work.
The paper through different animal model, Observer the Anzhi anti-inflammatory tablets in anti-inflammatory, analgesic, and the hemostatic effect. Research on treatment of hemorrhoids and the drug is difficult to walk upright hemorrhoids unique human, Because of its anatomy and physiology of reasons, Difficult to walk with the animals limbs copy of hemorrhoids to simulate human pathology model.Therefore,hemorrhoids in the pharmacodynamics of no fixed on the animal model, According to hemorrhoids clinical symptoms of pain, swelling, bleeding, Application of anti-inflammatory, analgesic, to stop bleeding, anti-ulcer anal experimental methods prove the Pharmacodynamics. Using mice ear edema, abdominal vascular permeability law and swelling of feet,The results show that anti-inflammatory tablets Anzhi mice can significantly improve the auricle local blood circulation, Of xylene-induced acute inflammation has obvious anti-inflammatory swelling, Acetate can significantly reduce the peritoneal permeability caused by the increase of hyperthyroidism, Of the egg white rat paw edema can be inhibited. in analgesia,Using hot plate and writhing law,The results show that anti-inflammatory tablets Anzhi mice did not increase the thermal resistance of mice can not increase the pain threshold, On the pain caused by acetic acid, it has inhibitinon significantly and reduced the number of mice writhing. In hemostasis, By Duan Wei, capillary glass tube slide of law and prove that there are obvious bleeding, clotting effect.Of acetic acid-induced ulcer in the anus ,Anzhi anti-inflammatory tablets t can reduce the leakage of the anus and promote the anal ulcer healing. Through this experimental anti-inflammatory tablets Anzhi animals for clinical drug research provides an important basis.
引文
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[2]谢锦生.五倍子洗剂治疗痔疮[J].河南中医,2003,05:12.
[3]杨吉水.止痛如神汤治疗痔疮178例[J].中医外治杂志,1996,(2):42
[4]王明轩.三黄熏洗汤治疗炎性痔106例疗效观察[J].湖南中医杂志,2004,20(4):32
[5]王常民.盖秀花.桓树学.苦冰洗剂治疗痔疮130例[J].中医外治杂志,2003,12(3):46
[6]董善鼎.三味汤熏洗治疗痔疮196例[J].中国民间疗法,2001,9(6):28
[7]杨光.汤良庚.王为.熏洗Ⅰ号治疗痔疮146例[J].南京中医药大学学报,1995,11(4):57
[8]邱正堂.冷红兰.中药熏洗治疗痔疮38例[J].中医外治杂志,2004,13(3):47
[9]刘芙蓉.陈霞.水晶丹熏洗治疗痔疮120例[J].现代中西医结合杂志,2003,12(3):275
[10]徐伟祥.徐秀凤.丁春华.外用熏洗方治疗痔疮500例[J].上海中医药杂志,2000,9:32
[11]王克非.消痔浴治疗炎性外痔85例临床观察[J].中医外治杂志,2002,11(5):43
[12]韩吉华.孙继芬.杜鹃.双硝散坐浴治疗痔疮50例[J].中国民间疗法,2004,12(2):24
[13]李立.左进.武文红.三黄汤加味坐浴治疗痔疮临床疗效观察[J].内蒙古中医药,2003,(4):8
[14]周志成.消痔洗剂坐浴治疗痔疮132例[J].中国中医药科技,1998,5(6):362
[15]张茂香.中药坐浴治疗痔疮200例疗效观察[J].黑龙江中医药,1999,4:98
[16]陈霞.复方坐浴液治疗痔疮的临床观察[J].云南中医中药杂志,2001,8(1):21
[17]吴建国.韭菜汤坐浴治疗痔疮[J].中国针灸,2003,23(10):603
[18]梁劲军.吴维城.李华山.等.敷痔散治疗嵌顿痔95例疗效观察[J].新中医,2000,32(5):15
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