新止骨增生丸和透明质酸钠治疗膝骨关节炎的临床疗效分析
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摘要
目的:探讨运用中西医两种方法治疗膝关节骨关节炎的临床疗效。
方法:选择160例门诊病例,并随机分为试验组和对照组,试验组采用新止骨增生丸口服和透明质酸钠注射液关节腔内注射治疗,对照组采用透明质酸钠注射液关节腔内注射治疗。
结果:平均随访八个月,根据国家中医药管理局制定的《中医病证诊断疗效标准》和Michel Lequesen膝骨性关节炎严重性评分标准,试验组临床治愈15例,显效42例,有效16例,无效7例,总有效率为91.25%,对照组临床治愈3例,显效12例,有效29例,无效36例,总有效率为55.0%,治疗前后在膝关节功能评分方面比较P＜0.05,有统计学差异。
结论:采用中西两种方法治疗膝骨性关节炎疗效确切,值得采用。
Purpose: To explore the clinical efficacy of Chinese and Western treatment in the cure of osteoarthritis of knee.
Method: Select 160 outpatient cases and randomly divided into two groups. Thetest adopts new bone hyperplasia pills for oral and injection of sodium hyaluronate intra-articular injections for the treatment. The control uses sodium hyaluronate injection into the articular cavity for the treatment.
Results: Average follow-up for eight months, according to the state administration of traditional Chinese medicine for the diagnosis of disease and syndrome curative standard and Michel Lequesne knee osteoarthritis severity rating criteria, the test clinical cure 15 cases, powerfully 42 cases ,effective 16 cases, invalid 7 cases. The effective rate is 91.25%; The control clinical cure 3 cases, powerfully 12 cases ,effective 29 cases, invalid 36 cases. The effective rate is 55.0%; Before and after the treatment the two groups on knee functional score compare P<0.05, there are significant difference in statistics.
Conclusion: The use of Chinese and Western treatment for osteoarthritis of knee is exactly effect ,worthy of use.
方法:选择160例门诊病例,并随机分为试验组和对照组,试验组采用新止骨增生丸口服和透明质酸钠注射液关节腔内注射治疗,对照组采用透明质酸钠注射液关节腔内注射治疗。
结果:平均随访八个月,根据国家中医药管理局制定的《中医病证诊断疗效标准》和Michel Lequesen膝骨性关节炎严重性评分标准,试验组临床治愈15例,显效42例,有效16例,无效7例,总有效率为91.25%,对照组临床治愈3例,显效12例,有效29例,无效36例,总有效率为55.0%,治疗前后在膝关节功能评分方面比较P＜0.05,有统计学差异。
结论:采用中西两种方法治疗膝骨性关节炎疗效确切,值得采用。
Purpose: To explore the clinical efficacy of Chinese and Western treatment in the cure of osteoarthritis of knee.
Method: Select 160 outpatient cases and randomly divided into two groups. Thetest adopts new bone hyperplasia pills for oral and injection of sodium hyaluronate intra-articular injections for the treatment. The control uses sodium hyaluronate injection into the articular cavity for the treatment.
Results: Average follow-up for eight months, according to the state administration of traditional Chinese medicine for the diagnosis of disease and syndrome curative standard and Michel Lequesne knee osteoarthritis severity rating criteria, the test clinical cure 15 cases, powerfully 42 cases ,effective 16 cases, invalid 7 cases. The effective rate is 91.25%; The control clinical cure 3 cases, powerfully 12 cases ,effective 29 cases, invalid 36 cases. The effective rate is 55.0%; Before and after the treatment the two groups on knee functional score compare P<0.05, there are significant difference in statistics.
Conclusion: The use of Chinese and Western treatment for osteoarthritis of knee is exactly effect ,worthy of use.
引文
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[2]王群,邵卫.膝骨性关节炎的研究进展[J].上海医学,1997,20(9):557-559.
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[4]吴在德,吴肇汉.外科学(第六版)[M]北京:人民卫生出版社,2004:909-910.
[5]毕五蝉,王亦璁.膝关节载荷传导紊乱所致关节炎关节软骨退变[J].中华骨科杂志,1991,11:303.
[6]姚树源.痹祺胶囊治疗膝骨性关节炎的临床观察[J].天津中医药,2004,21(4):285-286.
[7]吕建国,郑清莲.补肾活血方剂治疗膝关节退行性关节炎165例[J].陕西中医,2006,27(8):949-950.
[8]程玉来.复方通痹胶囊治疗膝关节骨性关节炎300例临床分析[J].中华现代临床医学杂志,2003,1(7):633-634.
[9]王春秋,王新卫.骨痹通治疗膝关节骨性关节炎92例[J].四川中医,2003,21(4):67-68.
[10]熊越海,熊暑林.自拟膝痹舒痛饮治疗膝骨性关节炎疗效观察[J].中医正骨,2007,19(1):31-32.
[11]陈远林,邱仁斌,沈瑞子,等。补肾活血法治疗膝骨关节炎49例临床观察[J].国际医药卫生导报,2005,11(14):114-115.
[12]顾玉潜.独活寄生汤治疗膝关节骨性关节炎60例疗效观察[J].长春中医药大学学报,2008,24(2):202-203.
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[20]邓伟,伍新林.手法治疗膝骨性关节炎的临床研究[J].中华实用中西医杂志,2005,18(7):1027-1028.
[21]张先勇.中药配合物理疗法防治结合治疗膝关节骨性关节炎350例临床总结[J]。成都中医药大学学报,2006,29(2):17-18。
[22]杨梦林,华刚,刘守新.中药加针灸治疗膝关节骨性关节炎164例[J].吉林中医药,2007,27(2):41。
[23]唐树杰,刘复奇.中药熏洗并推拿治疗膝关节骨性关节炎78例[J].辽宁中医学院学报,2003,5(4):367。
[24]蔡水奇,华全科,徐水军,等.综合治疗膝骨性关节炎126例报告[J].中医正骨,2007,19(5):4344。
[25]徐建武,丁建中.手法配合中药外洗治疗膝关节骨性关节炎的临床疗效观察[J].首都体育学院学报,2005,17(1):25-38.
[26]胡胜平.中医药为主治疗膝关节骨关节炎53例临床观察[J].中医药导报,2007,13(5):53-54.
[27]Sandberg MM,Aro HT,Vuorio E.Gene express of bone repair[J].Clin Orthop and Related Research,1993,289:292.
[28]陈百成,张静.骨关节炎[M].北京:人民卫生出版社,2004:378-379.
[29]陈百成,张静.骨关节炎[M].北京:.人民卫生出版社,2004:376-377.
[30]马玉林,马强,张明军,等.玻璃酸钠膝关节腔注射治疗骨性关节炎[J].宁夏医学杂志,2006,28(4):265-266.
[31]杨菊玲,张李丽.施沛特关节腔内注射治疗膝关节骨性关节炎[J].中华临床医学研究杂志,2003,70:11682.
[32]Admin ARI.Type interleukin-1 beta receptor:A candidate for Gene therapy in human arthritis[J].Clin Orthop,2OOO,379(suppl):170-188.
[33]Frisbie nn,Mcwraith CW.Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis[J].Clin Orthop,2000,379(suppl):273-287.
[34]于德刚,董纪元,王岩.人工膝关节单髁置换术36例临床应用特点:1年随访影像学及膝关节功能评估[J].中国组织工程研究与临床康复,2007,11(51):10246-10250.
[35]郭万首,刘朝辉,程立明,等.小切口单髁置换术治疗膝关节骨性关节炎[J].中日友好医院学报,2008,22(5):263-265.
[36]Insall JN,Dorr LD,Scott RD,et al.Rationale of the Knee Society clicinal rating system[J].Clin Orthop,1989,(248):13-14.
[37]冯世春.全膝关节表面置换22例临床分析[J].基层医学论坛,2008,12(9):784-785.
[38]吕厚山.骨性关节炎的外科治疗[J].中华全科医师杂志,2003,2(6):344-345.
[39]Homminga GN,Bulstra SK,Bouwmeester PS,et al.Perichondral grafting for cartilage lesions of the knee[J].Bone Joint Surg(Br),1990,72(6):1003-1007.
[40]Bouwmeester SJ,Beckers JM,Kui jer R,et al.Long-term result of rib perichondral graft for repair of cartilage defects in the human knee[J].Orthop,1997,21:313-319.
[41]Rubin CT,Lanyon LE.Regulation of bone formation by applied dynamic loads.[J].Bone Joint Surg,1984,66(3):397.
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[3]Sliver FH,Bradica G,Tria A.Relationshp among biomechanical,biochemical,and celluar chang associated with osteoarthritiso Crit Rev Biomed Eng 2001,29(4):374-378.
[4]吴在德,吴肇汉.外科学(第六版)[M]北京:人民卫生出版社,2004:909-910.
[5]毕五蝉,王亦璁.膝关节载荷传导紊乱所致关节炎关节软骨退变[J].中华骨科杂志,1991,11:303.
[6]姚树源.痹祺胶囊治疗膝骨性关节炎的临床观察[J].天津中医药,2004,21(4):285-286.
[7]吕建国,郑清莲.补肾活血方剂治疗膝关节退行性关节炎165例[J].陕西中医,2006,27(8):949-950.
[8]程玉来.复方通痹胶囊治疗膝关节骨性关节炎300例临床分析[J].中华现代临床医学杂志,2003,1(7):633-634.
[9]王春秋,王新卫.骨痹通治疗膝关节骨性关节炎92例[J].四川中医,2003,21(4):67-68.
[10]熊越海,熊暑林.自拟膝痹舒痛饮治疗膝骨性关节炎疗效观察[J].中医正骨,2007,19(1):31-32.
[11]陈远林,邱仁斌,沈瑞子,等。补肾活血法治疗膝骨关节炎49例临床观察[J].国际医药卫生导报,2005,11(14):114-115.
[12]顾玉潜.独活寄生汤治疗膝关节骨性关节炎60例疗效观察[J].长春中医药大学学报,2008,24(2):202-203.
[13]冯国军,席占东,郭继芳.自拟活血舒筋洗剂治疗报道[J].北京中医,2004,23(6):356-357.
[14]许二平,李根林,杨钦河,等.骨痹贴治疗骨性关节炎78例[J].新中医,2002,34(10):56.
[15]李文庆,王胜利,朱通伯.骨伤风湿膏治疗膝骨关节病的临床观察[J].中国中医骨伤科杂志,2000,8(4):42-43.
[16]孙娟,陈晔,沈娟清.中药离子导入治疗慢性骨关节病[J].中国骨伤,1999,12(5):5.
[17]李雁,毋中安.电脑中频药物导入治疗膝关节骨关节炎60例[J].中医研究,2002,15(5):33.
[18]张玉柱,徐超英,郭进修.推拿治疗增生性膝关节炎68例报告[J].中医正骨,1999,11(6):26.
[19]谢凯,苏继承,胡兴山,等.磁化砭针治疗膝关节增生性关节炎60例报告[J].中医正骨,1999,11(1):27.
[20]邓伟,伍新林.手法治疗膝骨性关节炎的临床研究[J].中华实用中西医杂志,2005,18(7):1027-1028.
[21]张先勇.中药配合物理疗法防治结合治疗膝关节骨性关节炎350例临床总结[J]。成都中医药大学学报,2006,29(2):17-18。
[22]杨梦林,华刚,刘守新.中药加针灸治疗膝关节骨性关节炎164例[J].吉林中医药,2007,27(2):41。
[23]唐树杰,刘复奇.中药熏洗并推拿治疗膝关节骨性关节炎78例[J].辽宁中医学院学报,2003,5(4):367。
[24]蔡水奇,华全科,徐水军,等.综合治疗膝骨性关节炎126例报告[J].中医正骨,2007,19(5):4344。
[25]徐建武,丁建中.手法配合中药外洗治疗膝关节骨性关节炎的临床疗效观察[J].首都体育学院学报,2005,17(1):25-38.
[26]胡胜平.中医药为主治疗膝关节骨关节炎53例临床观察[J].中医药导报,2007,13(5):53-54.
[27]Sandberg MM,Aro HT,Vuorio E.Gene express of bone repair[J].Clin Orthop and Related Research,1993,289:292.
[28]陈百成,张静.骨关节炎[M].北京:人民卫生出版社,2004:378-379.
[29]陈百成,张静.骨关节炎[M].北京:.人民卫生出版社,2004:376-377.
[30]马玉林,马强,张明军,等.玻璃酸钠膝关节腔注射治疗骨性关节炎[J].宁夏医学杂志,2006,28(4):265-266.
[31]杨菊玲,张李丽.施沛特关节腔内注射治疗膝关节骨性关节炎[J].中华临床医学研究杂志,2003,70:11682.
[32]Admin ARI.Type interleukin-1 beta receptor:A candidate for Gene therapy in human arthritis[J].Clin Orthop,2OOO,379(suppl):170-188.
[33]Frisbie nn,Mcwraith CW.Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis[J].Clin Orthop,2000,379(suppl):273-287.
[34]于德刚,董纪元,王岩.人工膝关节单髁置换术36例临床应用特点:1年随访影像学及膝关节功能评估[J].中国组织工程研究与临床康复,2007,11(51):10246-10250.
[35]郭万首,刘朝辉,程立明,等.小切口单髁置换术治疗膝关节骨性关节炎[J].中日友好医院学报,2008,22(5):263-265.
[36]Insall JN,Dorr LD,Scott RD,et al.Rationale of the Knee Society clicinal rating system[J].Clin Orthop,1989,(248):13-14.
[37]冯世春.全膝关节表面置换22例临床分析[J].基层医学论坛,2008,12(9):784-785.
[38]吕厚山.骨性关节炎的外科治疗[J].中华全科医师杂志,2003,2(6):344-345.
[39]Homminga GN,Bulstra SK,Bouwmeester PS,et al.Perichondral grafting for cartilage lesions of the knee[J].Bone Joint Surg(Br),1990,72(6):1003-1007.
[40]Bouwmeester SJ,Beckers JM,Kui jer R,et al.Long-term result of rib perichondral graft for repair of cartilage defects in the human knee[J].Orthop,1997,21:313-319.
[41]Rubin CT,Lanyon LE.Regulation of bone formation by applied dynamic loads.[J].Bone Joint Surg,1984,66(3):397.
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