中药百部归经的研究及其在海洋中药研发中的应用
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摘要
随着海洋开发力度的加强,海洋药用资源的的极大丰富为海洋中药的发展提供了广阔的前景。如何加快海洋药用资源的开发,将丰富的海洋药用资源充分的开发利用于临床成为海洋科技工作者面临的重要课题。利用现代成药理论,对海洋药用资源中的天然产物成分分离提取,进而研究其药理药效作用的方法虽然能够从海洋生物中获得很多活性的化合物,但能够进入临床的候选药物极其有限,即使进入临床研究,淘汰的几率也较大,无法充分利用如此大量的海洋药用资源。
中医药理论是我国独特的医药理论,在中华民族数千年的繁衍生息中起到了举足轻重的作用,而对中医药理论的解析及应用对于海洋中药的开发将起到巨大的推动作用。归经理论是中医药理论的重要组成部分,其不但可以有效指导临床用药,还能开发药物的潜在功效,因而在发展海洋中药的过程中借鉴归经理论,不但能够提高海洋中药研发的针对性,还能扩大海洋中药筛选的范围。在继承传统海洋中药的基础加以创新,借鉴中医药理论指导,运用现代科学技术,开发高效的符合中药特点的新型海洋中药。
本论文在实验室前期工作的基础上,选择一味归肺经的中药百部,对其含有的化学成分包括无机元素、氨基酸、多糖及生物碱类成分进行研究,重点对其入血成分进行研究,结果表明中药百部的入血成分为百部新碱。对百部新碱进行药代动力学和组织分布研究,结果表明百部新碱在大鼠体内的药代动力学呈二室模型,达峰时间为1.67±0.11h,血药峰值浓度为44.35±4.67μg/mL,生物利用度为12.41%；百部新碱在大鼠各脏器中均有所分布,90min时在肺组织中的分布最高,提示百部新碱的分布的确具有靶向性,这与其归肺经的论断是相一致的；百部新碱能够穿过血脑屏障在脑组织中分布且在120min时达到峰值,这与文献报道百部生物碱既有外周镇咳作用,也具有中枢镇咳作用相一致。
在对百部单味药研究的基础上,对含有百部的中药复方止嗽散进行研究,探讨复方给药对百部归经的影响。药代动力学研究表明,给药止嗽散后,百部新碱同样呈二室模型,达峰时间1.30±0.27h,血药峰值浓度为47.57±9.61μg/ml,生物利用度为19.19%。组织分布研究表明给药止嗽散后,百部新碱在各组织中迅速分布,90min时在肺组织中的分布最高,且高于其他组织,也高于百部单味药给药时的肺组织浓度,同时百部新碱也能够穿越血脑屏障,120min时在脑组织中分布最高。药代动力学和组织分布结果表明,复方给药能够提高百部新碱的生物利用度,促进其在组织中的分布浓度,但是并没有改变百部的归经本质。
在对止嗽散研究的基础上,对构成复方的中药成分进行总结,总结其含有的对肺部疾病起主要药效作用的化合物类型及其其结构信息。结果表明生物碱,黄酮,甾体和萜类成分是止嗽散的药效物质基础。经过对化合物的结构与活性的关系进行总结后,选择含有相类似成分及药效作用的海洋中药柽柳和海藻来替换止嗽散中陆地中药陈皮与白前,组成新的海洋复方。对含有百部的海洋自拟方进行研究,探讨替换后的海洋自拟方对百部归经的影响。药代动力学研究表明,给药海洋自拟方后,百部新碱同样呈二室模型,达峰时间1.20±0.27h,血药峰值浓度为45.16±9.74μg/ml,生物利用度为19.29%。组织分布研究表明给药海洋自拟方后,与给药止嗽散相似,百部新碱在各组织中迅速分布,90min时在肺组织中的分布最高,且高于其他组织,也高于百部单味药给药时的肺组织浓度,同时百部新碱也能够穿越血脑屏障,120min时在脑组织中分布最高。药代动力学和组织分布结果表明,替换后的海洋自拟方也能够提高百部新碱的生物利用度,促进其在组织中的分布浓度,而且也没有改变百部的归经本质。
以止咳,平喘和祛痰三种药效指标对止嗽散和海洋自拟方进行药效对比研究,结果表明,两种复方在这三种药效上均具有很大的相似性,其中海洋自拟方的平喘作用强于原方且具有显著性差异,说明海藻和柽柳的组合对于复方的平喘作用具有重要的影响。
以上结果显示以百部的药效成分的组织分布对百部的归经进行判断是可行的,而复方给药对于百部中药效成分的靶向分布具有促进作用,说明复方给药能够增强药物的归经作用；以含有相似化学结构与药理活性的海洋中药来代替复方中的陆地中药能够产生相近甚至更好的药效作用,为海洋中药的开发利用提供了一条崭新的思路,在此思路指引下,可以对海洋中的大量海洋药用资源进行研究,从而更加有效的开发利用海洋中药。
With the the ocean exploitation, the abundance of marine drug resources provided the Traditional Marine Chinese Medicine (TMCM) with a broad prospect. It became an essential issue to promote the development of marine drug resources and apply them on clinic for the oceanic scientists. Many compounds were obtained from the marine organisms after the separations of the marine drug resources. A lot of compounds were tested for various activities but a few of them became the candidates and were studied on clinic which may be still condemned at last, therefore, lots of marine drug resources couldn't be used on clinic.
The theory of Traditional Chinese Medicine is an unique theory in China and played an important role on the health of the people in China for thousands of years. The modern analysis and application of the theory of Traditional Chinese Medicine may play a huge role in promoting the development of Marine Chinese Medicine. Meridian Tropism Theory (MTT) is an important part of the theory of Traditional Chinese Medicine which can not only instruct rational use of drugs in clinic practice but also develop the potential efficacy of the drug. So applying the MTT to develop the marine drug could not only improve the target of the marine drug but also expand the screening range of the marine drug.
The study was based on the preliminary work of our laboratory and selected Baibu (Stemona tuberosa Lour.) which was a traditional drug of Lung Meridian Tropism to study its chemical components such as mineral elements, amino acids, polysaccharides. alkaloids and especially its migration component in plasma. The results showed that the stemoninine was its migration component in plasma. The pharmacokinetics of stemoninine showed that its in vivo behavior could be described with two-compartment mode and the Tmax and Cmax were 1.67±0.11 h and 44.35±4.67μg/mL after oral administration of STE. The bioavailability of stemoninine was 12.41%. The tissue distributions showed that the stemoninine could distribute in the tissues and achieved the max concentration in lung at 90 min which suggested that the distribution of stemoninine was targeted. The result was concordant with the traditional judgement of Baibu. Besides, the stemoninine could permeate the blood-brain barrier and achieve the max concentration in brain at 120 min. The stemoninine was reported to exert its antitussive action via both central and peripheral actions which concordant with its tissue distributions.
Base on the studies of the Baibu, a continue study was carried out on the complex prescription "Zhi Sou San" which contents the Baibu. The influence of the complex prescription on the meridian tropism on Baibu was approached. The pharmacokinetics results showed that the in vivo behavior of stemoninine was still two-compartment mode and the Tmax and Cmax were 1.30±0.27 h and 47.57±9.61μg/mL after oral administration of "Zhi Sou San". The bioavailability of stemoninine was 19.19%. The tissue distributions showed that the stemoninine could distribute in the tissues and also achieved the max concentration in lung at 90 min and in brain at 120 min. The results showed that the complex prescription could promote the bioavailability and tissue distribution concentrations but not change the meridian tropism on Baibu.
The pharmacodynamic components of the "Zhi Sou San" were summaried and the results showed that alkaloids, flavones, steroids and terpenes were the pharmacodynamic foundations of the "Zhi Sou San". After a summary of relationship between the chemical structures and activities, two marine Chinese medicine Chengliu (Tamarix chinensis Lour.) and Haizao (Sargassum pallidum (Turn.) C. Ag.) were selected to replace the Chenpi (Citrus reticulata Blanco.) and Baiqian (Cynanchum stauntonii (Decne.) Schltr. ex levl.) and a new complex prescription was made which was called "Hai Yang Zi Ni Fang". The continue study was similar to the study of "Zhi Sou San". The influence of the new complex prescription on the meridian tropism on Baibu was approached. The pharmacokinetics results showed that the in vivo behavior of stemoninine was still two-compartment mode and the Tmax and Cmax were 1.20±0.27 h and 45.16±9.74μg/mL after oral administration of "Hai Yang Zi Ni Fang". The bioavailability of stemoninine was 19.29%. The tissue distributions showed that the stemoninine could distribute in the tissues and also achieved the max concentration in lung at 90 min and in brain at 120 min. The results showed that the new complex prescription could also promote the bioavailability and tissue distribution concentrations but not change the meridian tropism on Baibu.
Three kinds of pharmacological activity including antitussive, antiasthmatic and expectorant were selected to compare the "Zhi Sou San" with "Hai Yang Zi Ni Fang" The results showed that the two complex prescriptions were similar on the pharmacodynamic actions except for the antiasthmatic, of which the latter was more powerful than the former. The result suggested that the combination of Chengliu and Haizao had an important contribution to the antiasthmatic activity of the "Hai Yang Zi Ni Fang".
The above results showed that it was feasible to the judge the meridian tropism on Baibu by the tissue distributions of the pharmacodynamic component. The complex prescriptions could promote the targeted distribution of stemoninine which suggested that the complex prescriptions could enhance the meridian tropism action of Baibu. After replacing marine Chinese medicines which had similar chemical structures and pharmaco-activities with the land medicines, the complex prescription could display a similar even more powerful pharmacodynamic action, which provided a brand-new path to utilize the marine drug resources with much efficiency.
中医药理论是我国独特的医药理论,在中华民族数千年的繁衍生息中起到了举足轻重的作用,而对中医药理论的解析及应用对于海洋中药的开发将起到巨大的推动作用。归经理论是中医药理论的重要组成部分,其不但可以有效指导临床用药,还能开发药物的潜在功效,因而在发展海洋中药的过程中借鉴归经理论,不但能够提高海洋中药研发的针对性,还能扩大海洋中药筛选的范围。在继承传统海洋中药的基础加以创新,借鉴中医药理论指导,运用现代科学技术,开发高效的符合中药特点的新型海洋中药。
本论文在实验室前期工作的基础上,选择一味归肺经的中药百部,对其含有的化学成分包括无机元素、氨基酸、多糖及生物碱类成分进行研究,重点对其入血成分进行研究,结果表明中药百部的入血成分为百部新碱。对百部新碱进行药代动力学和组织分布研究,结果表明百部新碱在大鼠体内的药代动力学呈二室模型,达峰时间为1.67±0.11h,血药峰值浓度为44.35±4.67μg/mL,生物利用度为12.41%；百部新碱在大鼠各脏器中均有所分布,90min时在肺组织中的分布最高,提示百部新碱的分布的确具有靶向性,这与其归肺经的论断是相一致的；百部新碱能够穿过血脑屏障在脑组织中分布且在120min时达到峰值,这与文献报道百部生物碱既有外周镇咳作用,也具有中枢镇咳作用相一致。
在对百部单味药研究的基础上,对含有百部的中药复方止嗽散进行研究,探讨复方给药对百部归经的影响。药代动力学研究表明,给药止嗽散后,百部新碱同样呈二室模型,达峰时间1.30±0.27h,血药峰值浓度为47.57±9.61μg/ml,生物利用度为19.19%。组织分布研究表明给药止嗽散后,百部新碱在各组织中迅速分布,90min时在肺组织中的分布最高,且高于其他组织,也高于百部单味药给药时的肺组织浓度,同时百部新碱也能够穿越血脑屏障,120min时在脑组织中分布最高。药代动力学和组织分布结果表明,复方给药能够提高百部新碱的生物利用度,促进其在组织中的分布浓度,但是并没有改变百部的归经本质。
在对止嗽散研究的基础上,对构成复方的中药成分进行总结,总结其含有的对肺部疾病起主要药效作用的化合物类型及其其结构信息。结果表明生物碱,黄酮,甾体和萜类成分是止嗽散的药效物质基础。经过对化合物的结构与活性的关系进行总结后,选择含有相类似成分及药效作用的海洋中药柽柳和海藻来替换止嗽散中陆地中药陈皮与白前,组成新的海洋复方。对含有百部的海洋自拟方进行研究,探讨替换后的海洋自拟方对百部归经的影响。药代动力学研究表明,给药海洋自拟方后,百部新碱同样呈二室模型,达峰时间1.20±0.27h,血药峰值浓度为45.16±9.74μg/ml,生物利用度为19.29%。组织分布研究表明给药海洋自拟方后,与给药止嗽散相似,百部新碱在各组织中迅速分布,90min时在肺组织中的分布最高,且高于其他组织,也高于百部单味药给药时的肺组织浓度,同时百部新碱也能够穿越血脑屏障,120min时在脑组织中分布最高。药代动力学和组织分布结果表明,替换后的海洋自拟方也能够提高百部新碱的生物利用度,促进其在组织中的分布浓度,而且也没有改变百部的归经本质。
以止咳,平喘和祛痰三种药效指标对止嗽散和海洋自拟方进行药效对比研究,结果表明,两种复方在这三种药效上均具有很大的相似性,其中海洋自拟方的平喘作用强于原方且具有显著性差异,说明海藻和柽柳的组合对于复方的平喘作用具有重要的影响。
以上结果显示以百部的药效成分的组织分布对百部的归经进行判断是可行的,而复方给药对于百部中药效成分的靶向分布具有促进作用,说明复方给药能够增强药物的归经作用；以含有相似化学结构与药理活性的海洋中药来代替复方中的陆地中药能够产生相近甚至更好的药效作用,为海洋中药的开发利用提供了一条崭新的思路,在此思路指引下,可以对海洋中的大量海洋药用资源进行研究,从而更加有效的开发利用海洋中药。
With the the ocean exploitation, the abundance of marine drug resources provided the Traditional Marine Chinese Medicine (TMCM) with a broad prospect. It became an essential issue to promote the development of marine drug resources and apply them on clinic for the oceanic scientists. Many compounds were obtained from the marine organisms after the separations of the marine drug resources. A lot of compounds were tested for various activities but a few of them became the candidates and were studied on clinic which may be still condemned at last, therefore, lots of marine drug resources couldn't be used on clinic.
The theory of Traditional Chinese Medicine is an unique theory in China and played an important role on the health of the people in China for thousands of years. The modern analysis and application of the theory of Traditional Chinese Medicine may play a huge role in promoting the development of Marine Chinese Medicine. Meridian Tropism Theory (MTT) is an important part of the theory of Traditional Chinese Medicine which can not only instruct rational use of drugs in clinic practice but also develop the potential efficacy of the drug. So applying the MTT to develop the marine drug could not only improve the target of the marine drug but also expand the screening range of the marine drug.
The study was based on the preliminary work of our laboratory and selected Baibu (Stemona tuberosa Lour.) which was a traditional drug of Lung Meridian Tropism to study its chemical components such as mineral elements, amino acids, polysaccharides. alkaloids and especially its migration component in plasma. The results showed that the stemoninine was its migration component in plasma. The pharmacokinetics of stemoninine showed that its in vivo behavior could be described with two-compartment mode and the Tmax and Cmax were 1.67±0.11 h and 44.35±4.67μg/mL after oral administration of STE. The bioavailability of stemoninine was 12.41%. The tissue distributions showed that the stemoninine could distribute in the tissues and achieved the max concentration in lung at 90 min which suggested that the distribution of stemoninine was targeted. The result was concordant with the traditional judgement of Baibu. Besides, the stemoninine could permeate the blood-brain barrier and achieve the max concentration in brain at 120 min. The stemoninine was reported to exert its antitussive action via both central and peripheral actions which concordant with its tissue distributions.
Base on the studies of the Baibu, a continue study was carried out on the complex prescription "Zhi Sou San" which contents the Baibu. The influence of the complex prescription on the meridian tropism on Baibu was approached. The pharmacokinetics results showed that the in vivo behavior of stemoninine was still two-compartment mode and the Tmax and Cmax were 1.30±0.27 h and 47.57±9.61μg/mL after oral administration of "Zhi Sou San". The bioavailability of stemoninine was 19.19%. The tissue distributions showed that the stemoninine could distribute in the tissues and also achieved the max concentration in lung at 90 min and in brain at 120 min. The results showed that the complex prescription could promote the bioavailability and tissue distribution concentrations but not change the meridian tropism on Baibu.
The pharmacodynamic components of the "Zhi Sou San" were summaried and the results showed that alkaloids, flavones, steroids and terpenes were the pharmacodynamic foundations of the "Zhi Sou San". After a summary of relationship between the chemical structures and activities, two marine Chinese medicine Chengliu (Tamarix chinensis Lour.) and Haizao (Sargassum pallidum (Turn.) C. Ag.) were selected to replace the Chenpi (Citrus reticulata Blanco.) and Baiqian (Cynanchum stauntonii (Decne.) Schltr. ex levl.) and a new complex prescription was made which was called "Hai Yang Zi Ni Fang". The continue study was similar to the study of "Zhi Sou San". The influence of the new complex prescription on the meridian tropism on Baibu was approached. The pharmacokinetics results showed that the in vivo behavior of stemoninine was still two-compartment mode and the Tmax and Cmax were 1.20±0.27 h and 45.16±9.74μg/mL after oral administration of "Hai Yang Zi Ni Fang". The bioavailability of stemoninine was 19.29%. The tissue distributions showed that the stemoninine could distribute in the tissues and also achieved the max concentration in lung at 90 min and in brain at 120 min. The results showed that the new complex prescription could also promote the bioavailability and tissue distribution concentrations but not change the meridian tropism on Baibu.
Three kinds of pharmacological activity including antitussive, antiasthmatic and expectorant were selected to compare the "Zhi Sou San" with "Hai Yang Zi Ni Fang" The results showed that the two complex prescriptions were similar on the pharmacodynamic actions except for the antiasthmatic, of which the latter was more powerful than the former. The result suggested that the combination of Chengliu and Haizao had an important contribution to the antiasthmatic activity of the "Hai Yang Zi Ni Fang".
The above results showed that it was feasible to the judge the meridian tropism on Baibu by the tissue distributions of the pharmacodynamic component. The complex prescriptions could promote the targeted distribution of stemoninine which suggested that the complex prescriptions could enhance the meridian tropism action of Baibu. After replacing marine Chinese medicines which had similar chemical structures and pharmaco-activities with the land medicines, the complex prescription could display a similar even more powerful pharmacodynamic action, which provided a brand-new path to utilize the marine drug resources with much efficiency.
引文
[1]郭雪申.海洋中药.北京：科学出版社.2003,6.
[2]连炜,叶波平.海洋天然抗肿瘤活性产物的临床研究现状.药学进展,2009,33(05)：204-211.
[3]谭仁祥,杨玲.浅谈海洋药物研究与开发战略.中国新药杂志.2000,9(7)：27-31.
[4]涂洪斌,卫剑文,彭立胜,等.药用海洋生物功能基因组研究.世界科学技术-中药现代化.2001,3(4)：3-9.
[5]Lee K H. Scientific Chinese herbal medicine:research and movements toward worldwide acceptance. J. Food & Drug Anal,1997, (5):233-234.
[6]Lee K H. Research and future trends in the pharmaceutical development of medicinal herbs from Chinsese medicine. Public Health Nutrition,2000, (3):515-522.
[7]李经纬,林昭庚.中国医学通史(古代卷).北京：人民卫生出版社.2000,684.
[8]李玉清.略论李时珍对归经学说的贞献.天津中医学院学报,2003,22(1)：7.
[9]杨大坚.中药归经理论的形成及在方剂靶向疗效中的作用.中医药学刊,2005,23(9)：1708.
[10]高晓山.归经引经涵义和理论源流浅识.中药归经理论学术会议资料,1984,002E.
[11]王新陆.脑血辩证-中医理论发展的探索.北京：中国医药科技出版社.2002,35.
[12]孙晓波.对确定中药归经依据的探讨.广西中西药,1999,22(2)：42.
[13]严永清,吴建新.药物的辛味与归经作用及化学成分的关系.中药通报,1987,12(1)：531.
[14]吉阳,宋秀珍.“归经”理论渊源初探.吉林中医药,1999,9(1)：2.
[15]蓝石.中药归经涵义之我见.黑龙江中医药,1983,(2)：41.
[16]凌一揆.中药学.上海：上海科技出版社.1984,10.
[17]刘继林.中药归经的讨论.中医杂志,1981,(2)：63.
[18]马峰升.试谈中药归经.云南中医学院学报,1981,(1)：16.
[19]王世民,杨勇.中药归经学说浅谈.山西中医,1985,1(1)：42.
[20]印会河.中医基础理论(五版)上海：上海科技出版社.1984,56.
[21]焦一鸣,王放,金凌,等.24味致淤药的性味、归经和功能分析.中医文献杂志,1995,(2)：17-18.
[22]李兴广,刘梅.常用中药归经的计算机分析.中医杂志,1994,35(5)：313-315.
[23]金日光,牟雪雁.中药归经学说的本质—关于中药传统理论的当代化学物理及群子(量
子)统计理论的诠释(Ⅳ).世界科学技术—中医药现代化,2004,6(2)：15-20.
[24]陆光伟.中药归经及其成分在体内的分布.中成药研究,1984,(5)：38.
[25]郭顺根,牛建昭,贲长恩.3H-川芎嗪在动物体内分布的放射自显影研究.中国医药学报,1989,4(3)：17.
[26]陈文垲,黄玉芳,王海东,等.麝香“归经入脑”的实验研究.中西医结合学报,2004,2(4)：288-291.
[27]上海第一医学院.药理学.北京：人民卫生出版社.1979,
[28]贲长恩,郭顺根.中药归经理论研究述评.北京中医药大学学报,1999,22(2)：2-7.
[29]王健,黎晓敏,贾仁勇,等.368味兽用中药材的性味、归经、毒性与11种元素含量关系的研究.畜牧兽医学报,1997,28(1)：90-96.
[30]李心河,刘少平,高海青,等.313种中药35种无机元素含量的研究.山东医科大学学报,1994,32(2)：174-179.
[31]徐经采,朱梅年.明目中药的归经与微量元素的关系.微量元素,1987,(2)：23.
[32]龚跃新,张根海.中药归经理论与微量元素的关系探讨.中医药研究,1990,(5)：23.
[33]付先军.中药归经(肺经)理论和肺系方剂配伍规律的解析及在海洋中药研发中的应用：[博士学位论文].青岛：中国海洋大学医药学院.2009,90.
[34]郑广华.阴阳学说与环核苷酸.自然杂志,1979,2(4)：208.
[35]武密山,李恩,赵素芝,等.补肾复方对骨质疏松大鼠细胞内信息调节的影响及其与药物归经相关性的实验研究.上海中医药杂志,2000,46(2)：44-46.
[36]王树荣,孙冰,丁国明.中药归经的实验研究.中国中药杂志,1994,19(8)：500-502.
[37]王树荣,翟继伟,盖英臣.天麻、桔梗、元胡归经的实验研究.上海中医药杂志,1995,(1)：44.
[38]叶显纯.论“归经”.山东中医学院学报,1980,(4)：11.
[39]史正新.中药归经与受体学说.陕西中医学院学报,1993,16(2)：4.
[40]王海东.中药归经理论研究现状及受体学说关系的论证.浙江中医杂志,2001,36(8)：323-326.
[41]徐树楠.中药归经现代研究方法探讨.中国药理学通报,2004,20(5)：598-600.
[42]李仪奎,徐莲英,马建平.中药药理和归经关系的统计分析.中药通报,1988,13(7)： 48-50.
[43]高其铭.当归的药理研究与其归经功效关系的探讨.中成药研究,1985,(5)：13.
[44]曾秀池.试述中药归经的现代研究.实用中医药杂志,2004,20(3)：154-155.
[1]Ji Z H, Duyfjes BEE. Stemonaceae. In Flora of China. Beijing:Science Press.2000,70-72.
[2]国家药典委员会.中华人民共和国药典：一部.北京：化学工业出版社.2005,88.
[3]Pilli RA, Ferreira de Oliveira MC. Recent progress in the chemistry of the Stemona alkaloids. Nat. Prod. Rep,2000,17(1):117-127.
[4]Pilli RA, Giovanni B. Rosso, Maria Da Conceicao F. De Oliveira. The Stemona Alkaloids. The Alkaloids:Chemistry and Biology,2005,(62):77-173.
[5]Jiang Ren-Wang, Hon Po-Ming, Zhou Yan, et al. Alkaloids and Chemical Diversity of Stemona tuberosa. J Nat Prod.,2006,69 (5):749-754.
[6]Qian Jie, Zhan Zha-Jun. Novel alkaloids from Stemona sessilifolia. Helvetica Chimica Acta, 2007,90 (2):326-331.
[7]Chung Hoi-Sing, Hon Po-Ming, Lin Ge, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med,2003,69 (10):914-920.
[8]Ye Yang, Qin Guo-Wei, Xu Ren-Sheng. Alkaloids from Stemona tuberosa. Phytochemistry, 1994,37 (4):1201-1203.
[9]Johann Schinnerl, Elisabeth Kaltenegger, Thomas Pacher, et al. New Pyrrolo[1,2-a]azepine Type Alkaloids from Stemona and Stichoneuron (Stemonaceae). Monatshefte fuer Chemie,2005, 136(9):1671-1680.
[10]Xu Ren-Sheng. Some bioactive natural products from Chinese medicinal plants.Studies in Natural Products Chemistry. Bioactive Natural Products (Part B),2000,21 729-772.
[11]Lin Wen-Han, Fu Hong-Zheng. Three new alkaloids from the roots of Stemona tuberosa Lour. Journal of Chinese Pharmaceutical Sciences,1999,8 (1):1-7.
[12]Zou Chang-Ying, Fu Hong-Zheng, Lei Hai-Min, et al. New alkaloids from the roots of Stemona japonica Miq. Journal of Chinese Pharmaceutical Sciences,1999,8(4):185-190.
[13]Kakuta Daichi, Hitotsuyanagi Yukio, Matsuura Naofumi. Structures of new alkaloids sessilifoliamides A-D from Stemona sessilifolia. Tetrahedron,2003,59 (39):7779-7786.
[14]Lin Wen-Han, Ye Yang, Xu Ren-Sheng. Chemical studies on new Stemona alkaloids, Ⅳ. Studies on new alkaloids from Stemona tuberosa. J Nat Prod.,1992,55 (5):571-576.
[15]Jiang Ren-Wang, Hon Po-Ming. But Paul Pui-Hay, et al. Isolation and stereochemistry of two new alkaloids from Stemona tuberosa. Tetrahedron,2002,58 (33):6705-6712.
[16]Zhou Yan, Jiang Ren-Wang, Hon Po-Ming, et al. Analyses of Stemona alkaloids in Stemona tuberosa by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom, 2006.20(6):1030-1038.
[17]Cheng Dong-liang, Guo Jia, Chu Tze Tsin, et al. A study of Stemona alkaloids, Ⅲ. Application of 2D-NMR spectroscopy in the structure determination of stemoninine. J Nat Prod.. 1988.51 (2):202-211.
[18]Lin Li-Gen, Zhong Qiong-Xing, Cheng Tin-Yan, et al. Stemoninines from the Roots of Stemona tuberosa. J Nat Prod.,2006,69(7):1051-1054.
[19]Wang Peng, Liu Ai-Lin, Li Zhi-Hong, et al. Stemoninine-type alkaloids from the roots of Stemona sessilifolia. J Asian Nat Prod Res.,2008,10 (4):311-314.
[20]Lin Wen-Han, Ma Li, Cai Meng-Shen, et al. Two minor alkaloids from roots of Stemona tuberosa. Phytochemistry,1994,36(5):1333-1335.
[21]Kondo Heisaburo, Satomi Masakichi. Stemona alkaloids. Ⅻ. Alkaloids from the roots of Stemona japonica and Stemona sessilifolia. Yakugaku Zasshi,1947, (67):182-184.
[22]Wang Peng, Liu Ai-Lin, An Zheng, et al. Novel alkaloids from the roots of Stemona sessilifolia. Chem Biodivers..2007,4 (3):523-530.
[23]Ye Yang, Xu Ren-Sheng. Studies on new alkaloids of Stemona japonica. Chinese Chemical Letters,1992,3 (7):511-514.
[24]Ye Yang, Qin Guo-Wei, Xu Ren-Sheng. Alkaloids of Stemona japonica. Phytochemistry, 1994.37(4):1205-1208.
[25]Zou Chang-Ying, Li Jun, Lei Hai-Min, et al. A new alkaloid from root of Stemona japonica Miq.. Journal of Chinese Pharmaceutical Sciences,2000,9 (3):113-115.
[26]Lin LG, Li KM, Tang CP, et al. Antitussive Stemoninine Alkaloids from the Roots of Stemona tuberosa. J. Nat. Prod.,2008,71 (6):1107-1110.
[27]Jiang Ren-Wang, Hon Po-Ming, Xu Yan-Tong, et al. Isolation and chemotaxonomic significance of tuberostemospironine-type alkaloids from Stemona tuberosa. Phytochemistry,2006, 67(1):52-57.
[28]Xu Ren-Sheng. Lu Yong-Jun. Chu Jen-Hun, et al. Studies on some new Stemona alkaloids. A diagnostically useful proton NMR line-broadening effect. Tetrahedron,1982,38(17):2667-2670.
[29]Sakata Kanzo, Aoki Katsuyuki, Chang Ching-Fung, et al. Stemospironine, a new insecticidal alkaloid of Stemona japonica Miq., isolation, structural determination and activity. Agricultural and Biological Chemistry,1978,42 (2):457-463.
[30]Lu Li-Hua, Ye Wen-Cai, Zhao Shou-Xun, et al. Chemical constituents of Stemona sessilifolia. Zhongguo Yaoke Daxue Xuebao,2005,36 (5):408-410.
[31]Ye Yang, Qin Guo-Wei, Xu Ren-Sheng. Studies on Stemona alkaloids. Ⅵ. Alkaloids of Stemona japonica. J Nat Prod.,1994,57 (5):665-669.
[32]Iizuka Hisho, Irie Hiroshi, Masaki Norior, et al. X-ray crystallographic determination of the structure of stemonamine. A new alkaloid from Stemona japonica. Isolation of isostemonamine. Journal of the Chemical Society, Chemical Communications,1973, (4):125-126.
[33]Wang Peng, Qin Hai-Lin, Li Zhi-Hong, et al. A new alkaloid from Stemona sessilifolia. Chinese Chemical Letters,2007,18 (2):152-154.
[34]Hitotsuyanagi Yukio, Hikita Maho, Oda Takahisa, et al. Structures of four new alkaloids from Stemona sessilifolia. Tetrahedron,2007,63 (4):1008-1013.
[35]Hitotsuyanagi Yukio, Hikita Maho, Nakada Kazuhiro, et al. Sessilifoliamide I, a new alkaloid from Stemona Sessilifolia. Heterocycles,2007,71 (9):2035-2040.
[36]H. Shinozaki, M. Ishida. Inhibitory actions of tuberostemonine on the excitatory transmission at the crayfish neuromuscular junction. Brain Research,1985,334 (1):33-40.
[37]Liu Zhi-Long, Goh Swee Hock, Ho Shuit Hung. Screening of Chinese medicinal herbs for bioactivity against Sitophilus zeamais Motschulsky and Tribolium castaneum (Herbst). Journal of Stored Products Research,2007,43 (3):290-296.
[38]Brigitte Brem, Christoph Seger, Thomas Pacher, et al. Feeding Deterrence and Contact Toxicity of Stemona Alkaloids-A Source of Potent Natural Insecticides. J. Agric. Food Chem, 2002,50 (22):6383-6388.
[39]Xu Yan-Tong, Hon Po-Ming, Jiang Ren-Wang, et al. Antitussive effects of Stemona tuberosa with different chemical profiles. J Ethnopharmacol,2006,108 (1):46-53.
[40]Yang Xin-Zhou, Zhu Jian-Yu, Tang Chun-Ping, et al. Alkaloids from roots of Stemona sessilifolia and their antitussive activities. Planta medica.2009,75 (2):174-177.
[41]Liao Jyh-Fei, Shi Chuen-Chao, Chen Su-Ying, et al. Spasmolytic effect of water extract of Stemonae radix on the guinea-pig tracheal smooth muscle in vitro. J Ethnopharmacol,1997,57 (1): 57-62.
[42]Rinner Beate, Siegl Veronika. Purstner Peter, et al. Activity of novel plant extracts against medullary thyroid carcinoma cells. Anticancer research,2004,24 (2A):495-500.
[43]王锋鹏.生物碱化学.北京：化学工业出版社.2008,19-29.
[44]丛晓东,徐国钧,金蓉鸾,等.百部生药学研究Ⅸ.中国百部属植物块根中总生物碱的测定与评估.药学学报,1992,27(7)：556-560.
[45]Li Song-Lin, Jiang Ren-Wang, Hon Po-Ming, et al. Quality evaluation of Radix Stemonae through simultaneous quantification of bioactive alkaloids by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. Biomed Chromatogr.,2007,21 (10):1088-1094.
[46]夏敏.必需微量元素的生理功能.微量元素与健康研究,2003,20(3)：41-44.
[47]何培之,王世驹,李续娥.普通化学.北京：科学出版社.2001,372-379.
[48]卢金清,黄芳,蒋胜军,等.金菊花中微量元素和氨基酸的含量分析.湖北中医学院学报,2006.8(1)：39-40.
[49]付先军.中药归经(肺经)理论和肺系方剂配伍规律的解析及在海洋中药研发中的应用：[博士学位论文].青岛：中国海洋大学医药学院.2009,90.
[50]陈月开.半胱氨酸的抑菌作用与类SOD活力.山西大学学报(自然科学版),2004,27(1)：65-67.
[51]张建新,李立萍,董淑婷,等.L-精氨酸对大鼠内毒素性肺损伤治疗作用的研究.中国药科大学学报.2004,35(4)：349-352.
[52]曾静,罗海吉.张勇,等.L-精氨酸对热应激小鼠胸腺T细胞业群的影响.热带医学杂志,2003,3(2)：155-157.
[53]Barbul Adrian. Wasserkrug Hannah L., Seifter Eli, et al. Immunostimulatory effects of arginine in normal and injured rats. Journal of Surgical Research,1980,29 (3):228-235.
[54]程俊文,吴学谦,孙培虎,等.灵芝多糖提取物胶囊对小鼠免疫功能的影响.中国食用菌,2009,28(6)：41-44.
[55]乔进,薛华,孟国梁,等.灵芝多糖对2型糖尿病大鼠胸主动脉内皮功能的保护作用.中国动脉硬化杂志,2009.17(9)：709-713.
[56]张勇,刘小玲,刘小雷.红景天多糖体外抗CVB3病毒活性.中国医院药学杂志,2009, 29(20)：1749-1753.
[57]龚海英,李建宇,梁林,等.枸杞多糖对神经元缺氧损伤的保护作用.武警医学院学报.2009,18(12)：1002-1017.
[58]王希玉,路莉,胡燕,等.不同红芪多糖抗肿瘤和免疫调节作用研究.中药药理与临床.2009,25(5)：72-74.
[59]陈永,安洪庆,宋利,等.红毛五加多糖中单糖组成的气相色谱分析.江苏中医药,2008,40(1)：65-66.
[60]大连轻工业学院.食品分析.北京：中国轻工业出版社.1994,177-180.
[61]李铁林,吴昌贤,张燕霞.糖和糖醇的气相色谱分析研究：Ⅱ.糖腈乙酰酯衍生物气相色谱分析的改进.分析化学,1982,10(5)：272.
[62]武汉大学.仪器分析.北京：高等教育出版社.2002,379.
[63]Cheng Donglian, Guo Jia, Chu Tze Tsin, et al. A STUDY OF STEMONA ALKALOIDS, III. APPLICATION OF 2D-NMR SPECTROSCOPY IN THE STRUCTURE DETERMINATION OF STEMONININE. Journal of Nature Products,1988,51(2):202-211.
[64]潘坚扬,赵筱萍,邵青.丹参素大鼠体内药代动力学及生物利用度研究.中国中药杂志,2008,33(2)：146-149.
[65]陈淑娟,杨毅梅,刘奕明,等.蝙蝠葛碱大鼠体内药物代谢动力学研究.中国药理学通报,2001,17(2)：225-229.
[66]张海防,郭健新,黄罗生,等.羟基红花黄色素A在大鼠体内的药代动力学.中国药科大学学报,2006,37(5)：456-460.
[67]顾轶,王广基,孙建国,等LC-MS法测定Beagle犬血浆中人参皂苷20(R)-Rh2及其药代动力学研究.中国临床药理学与治疗学,2006,11(3)：256-260.
[68]李静,王广基.药物胃肠道吸收屏障及新型促吸收方法.药学学报,2005,40(7)：600.
[69]Leung Pak Ho Henry. Chemical, pharmacological and intestinal absorption studies of Stemona alkaloids from Radix Stemonae[博士学位论文].香港：香港中文大学.2006.
[1]陈潮祖.中医治法与方剂.北京：人民卫生出版社.1995,245.
[2]林琳,罗细贞,张忠德.止嗽散加减治疗外感咳嗽证392例临床分析.按摩与引导,1999,15(5)：53-54.
[3]李景昌.止嗽散加味治疗老年性肺部感染89例.新中医,2000,32(7)：58-59.
[4]许轶兰.止嗽散加减治疗慢性支气管炎30例.中原医刊,1994,21(5)：44.
[5]徐雯.止嗽散为主治疗小儿支原体肺炎18例.浙江中医杂志,1997,32(12)：543.
[6]陈允旺,陈丽华.加味止嗽散治疗顽固性干咳50例-附西药治疗30例对照.黑龙江中医药,2002,(5)：27-28.
[7]冯桂贞,杨宜中,朱芳富.加味止嗽散治疗间质性肺炎30例.四川中医,1995,13(6)：29.
[8]陈秀虹.麻蝉止嗽散治疗百日咳.浙江中医学院学报,1994,18(3)：11.
[9]王志云,赵国云.加味止嗽散治疗百日咳40例.陕西中医,1994,15(8)：368.
[10]秦芝芳.代赭止嗽散加味治疗外感咳嗽疗效观察.河北中医,2000,22(8)：591.
[11]刘蕾,代立娟,赵玉珍,等.荆芥百部合剂药效学实验研究.黑龙江医药科学,2005,28(1)：33-34.
[12]徐乃玉.加味止嗽散平喘作用及其机制实验研究.[硕士学位论文],苏州：苏州大学,2003.
[13]Xu Yan-Tong, Hon Po-Ming, Jiang Ren-Wang, et al. Antitussive effects of Stemona tuberosa with different chemical profiles. J Ethnopharmacol,2006,108(1):46-53.
[14]Lin LG, Li KM, Tang CP, et al. Antitussive Stemoninine Alkaloids from the Roots of Stemona tuberosa. J. Nat. Prod.,2008,71 (6):1107-1110.
[15]Jiang Ren-Wang, Hon Po-Ming, Zhou Yan, et al. Alkaloids and chemical diversity of Stemona tuberosa. J Nat Prod,2006,69 (5):749-754.
[16]Chung Hoi-Sing, Hon Po-Ming, Lin Ge, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med,2003,69 (10):914-920.
[17]Takagi K, Lee E. B. Pharmacological studies on Platycodonrandiflorum A. DC. Yakgaku zasshi,1972,92 (8):969-973.
[18]Shin C. Y., Lee W. J., Lee E. B. Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters. PlantaMed,2002,68 (3):221-225.
[19]Lin N, Sato T, Takayama Y, et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblast and mouse macrophages. Biochem plarmacol,2003,65 (12):2065.
[20]卞如谦,杨秋水,任熙云,等.荆芥油的药理研究.浙江医科大学学报,1981,10(5)：219.
[21]郑虎占,董泽宏,佘靖.中药现代研究与应用.北京：学苑出版社.1999,3072.
[22]贺平,贾随旺,吴孟超,等.小鼠甘草酸的药代动力学及其与人血装蛋白结合率.中国药理学通报,1998,14(1)：89.
[23]吕小华,吴铁,覃冬云.甘草酸对哮喘小鼠一氧化氮及一氧化氮合酶的影响.时珍国医国药,2009,20(1)：40-41.
[24]Fu N W, Liu Z Y, Zhang R Y, et al. Studies from Glycyrrhiza Pharmacol Clin Chin Mater Med,1994, (5):26-29.
[25]娄红祥,李铣,朱廷儒.华北白前中的C21甾体类化合物.药学学报,1992,27(8)：595-602.
[26]龚小见.柳叶白前和多毛板凳果的化学成分研究.贵州大学硕士论文,2006.
[27]魏金婷,刘文奇.植物药活性成分β-谷甾醇研究概况.莆田学院学报,2007,14(2)：38-41.
[28]梁爱华.芫花叶白前的镇咳、祛痰及平喘作用.中国中药杂志,1995,20(3)：176.
[29]梁爱华,薛宝云,杨庆,等.柳叶白前的镇咳、祛痰及抗炎作用.中国中药杂志,1996,21(3)：173-175.
[30]吴坚东.板蓝根注射液在家兔体内药代动力学的评价.中成药研究,1993,15(3)：5.
[31]徐凯建,孙考祥,陆义成,等.“双黄连”注射剂与气雾剂的人体生物利用度研究.中国医院药学杂志,1992,12(11)：484.
[32]张志荣,胡晓颖,蒋大义,等.银黄冲剂中黄芩苷在家兔体内的代谢动力学研究.中成药研究,1996,18(6)：1.
[33]周莉玲,李锐,魏敏,等.丁公藤注射液的药动学相关性研究.中成药研究,1999,21(9)：439-440.
[34]富杭育,贺玉琢,周爱香.以解热的药效法初探麻黄汤、桂枝汤、银翘散、桑菊饮的药代动力学.中药药理与临床,1992,8(1)：1-7.
[35]富杭育,贺玉琢,周爱香.以发汗的药效法初探麻黄汤、桂枝汤、银翘散、桑菊饮的药 代动力学.中药药理与临床,1992,8(5)：1-5.
[36]贺玉琢,富杭育,周爱香.以抗炎的药效法再探麻黄汤、桂枝汤、银翘散、桑菊饮的药代动力学.中药药理与临床,1993,9(1)：1-4.
[37]富杭育,周爱香,贺玉琢.以抑制肠蠕动亢进作用再探麻黄汤、桂枝汤、银翘散、桑菊饮的药代动力学.中成药,1993,15(1)：35-36.
[38]赵智强,王小勤,陆跃鸣,等.镇肝熄风汤与天麻钩藤饮对小鼠自发活动抑制作用的药效动力学研究.中药药理与临床,1996,12(6)：23-25.
[39]赵智强,陆跃鸣,俞晶华,等.天麻钩藤饮等三方抗小鼠惊厥的药效动力学研究.中药药理与临床,1998,14(6)：4-6.
[40]赵智强,陆跃鸣,周仲瑛,等.天麻钩藤饮等三方对高血压大鼠模型降压作用的药效动力学研究.中药药理与临床,1999,15(4)：12-13.
[41]赵智强,陆跃呜,俞晶华,等.天麻钩藤饮等三方对小鼠自发活动效应的药效动力学研究.中药药理与临床,1999,15(1)：6-7.
[42]周京滋,陈长勋,苏健美,等.附子、四逆汤镇痛、抗炎作用的药效动力学研究.中国中药杂志,1992,17(2)：101.
[43]刘延福,赵福民,周毅生,等.小活络丸镇痛药效成分的药物动力学研究.中成药,1994,16(3)：34.
[44]卢贺起,张智,魏雅力,等.以药效法测定四物汤药动学参数的研究.中药药理与临床,1995,11(1)：11.
[45]任天池,王玉蓉,曾立品,等.用药物积累法考察九分散和疏风定痛丸的药物动力学实验.中成药,1991,13(7)：2.
[46]阴健,任天池,曹春林.黄芩苷及其在清开灵注射液中的药代动力学研究.中国实验方剂学杂志,1998,4(4)：31.
[47]常明向,徐莲英,陶建生.当归及其配伍对当归芍药汤的药动学研究.中药药理与临床,1992,8(4)：34.
[48]王晖,许卫铭,王宗锐.薄荷醇对柴胡镇痛成分表观生物利用度的影响.中成药,1996,18(6)：4-6.
[49]Yang Xiao-Ning, Wang Yan-Jiao, Liu Yu-Shi, et al. Pharmacokinetics of salvianolic acids after intravenous injection, with and without Panax quinquefolium protopanaxadiol saponins, in rats. Journal of ethnopharmacology,2008,117:408-414.
[50]沈群.麻黄汤不同配伍对麻黄碱和伪麻黄碱在小鼠体内药代动力学的影响.[硕士学位论文],广州：第一军医大学,2002.
[1]管华诗.我国海洋创新药物的研究和开发.中国天然药物,2006,4(1)：1.
[2]国家药典委员会.中华人民共和国药典(2005年版).北京：化学工业出版社.2005.
[3]徐国钧,王强.中草药彩色图谱.福州：福建科学技术出版社.2006,380-401.
[4]王巧玲.贾绍华.川陈皮素抗癌作用及机制的研究进展中草药,2009,40 40-42.
[5]Manthey J A, Guthrie N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J Agric Food Chemistry,2002,50 (21):5837-5843.
[6]Rodiiguez J, Yanez J, Vicente V, et al. Effects of several flavonoids on the growth of B16F10 and SK·MEL-1 melanoma cell lines:relationship between structure and activity. Melanoma Res, 2002,2(12):99-107.
[7]Kawaii S, Tomono Y, Katase E, et al. Effect of citrus flavonoids on HL-60 cell differentiation. Anticancer Res,1999,2A (19):0250-7005.
[8]Satoru K, Yasuhiko T, Eriko K, et al. Antiproliferative activity of flavonoidson several cancer cell lines. Biosci Biotechnol Biochem,1999,63(5):896-899.
[9]Bracke M, Vyncke B, Opdenakker G, et al. Effect of catechins and citrus flavonoids on invasionin vitro. Clin Exp Metastasis,1991,9 13-25.
[10]Takashi S, Leona K. Yoshiki M, et al. Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metallo-proteinases-1 and-9 in human fibrosarcoma HT-1080 cells. Cancer Res,2002, 62(4):1025-1029.
[11]Minagawa A, Otani Y, Kubota T. et al. The citrus flavonoid, nobiletin inhibit peritoneal dissemination of human gastric carcinoma in SCID mice. Jpn J Cancer Res,2001,92(12): 1322-1328.
[12]Garg A. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res, 2001,15 (2):655.
[13]季宇彬.中药有效成分药理与应用.哈尔滨：黑龙江科技出版社,1995,254.
[14]徐任生,叶阳,赵维民.天然产物化学.北京：科学出版社.2006,562-564.
[15]彭丽莎,方俊,孟德连,等.橙皮苷对病原微生物的影响.现代农业科技.2006,(10)：18-19.
[16]孙文基.天然活性成分简明手册.北京：中国医药科技出版社.1998,292.
[17]中国医学科学院药物研究所.中草药有效成分的研究.北京：人民卫生出版社.1972,396.
[18]娄桂予,江渝,彭家和.橙皮甙抗LDL氧化及对MCP-1mRNA转化的影响.第三军医大学学报,2004,26(8)：717-719.
[19]秦得安,王晓玲.橙皮苷对羟自由基的清除作用.中国药学杂志,1996,31(7)：390.
[20]秦得安,王晓玲.橙皮苷对羟自由基引发红细胞膜损伤的影响.中国药学杂志,1996,31(7)：396-398.
[21]李荣,李俊,胡成穆,等.橙皮苷对免疫功能低下小鼠免疫调节作用的实验研究.中国药理学通报,2007,23(2)：169-172.
[22]FernA Andez SebastiAAn P., W asowski Cristina, PaladiniAlejandro C, et al. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. European Journal ofPharmacology,2005,512 (2-3):189-198.
[23]T. Tanaka. Chemoprevention of human cancer:biology and therapy. Crit Rev. Oncol. /Hematol,1997,25 139-174.
[24]S.V. Jovanovic, S. Steenken, M. Tosic, et al. Simic Flovoniods as Antioxidants. J. Am. Chem. Soc,1994,116 4846.
[25]张秀尧,凌罗庆,毛泉明.西河柳化学成分的研究.中草药,1991,22(7)：229-230.
[26]张秀尧,凌罗庆,毛泉明.西河柳化学成分的研究.中草药,1989,20(8)：4-5.
[27]许福泉.柽柳和萹蓄归经的比较研究.中国海洋大学博士论文,2009,
[28]王斌.黄河三角洲滨海湿地药用耐盐植物蒙古鸦葱和柽柳化学成分及生物活性研究.[博士学位论文],青岛：中国海洋大学,2007.
[29]宋霞林,黄子君.西河柳槲皮素和异鼠李素在植物体内分布及随季节变化.中国药师,2007,10(5)：459-461.
[30]姜岩清,左春旭.柽柳化学成分的研究.药学学报,1988,23(10)：749-755.
[31]Yang L L, Yen K Y, Kiso Y, et al. Antihepatotoxic actions of Formosan plant drugs. Journal of ethnopharmacology,1987,19 (1):103-110.
[32]吴慧英.西河柳治痹.江西中医药,1996,(增刊)：94.
[33]赵润洲,孙仕银,陈发奎,等.西河柳药理作用的研究.中草药,1995,26(2)：85.
[34]张媛,屠鹏飞.柽柳属药用植物研究进展.中草药,2008,39(6)：947-951.
[35]Sultanova N. Makhmoor T, Abilov Z A. et al. Antioxidant and antimicrobial activities of Tamarix ramosissima. Journal of ethnopharmacology,2001,28 (2-3):201-205.
[36]Fazilatun N, Nornisah M, Zhari I. Superoxide radical scavenging properties of extracts and flavonoids isolated from the leaves of Blumea balsamifera. Pharmaceutical Biology.2005,43 (1): 15-20.
[37]Nessa F, Ismail Z, Mohamed N. Free radical-scavenging activity of organic extracts and of pure flavonoids of Blumea balsamifera DC leaves. Food Chemistry,2004,88 (2):243-252.
[38]Edenharder R, Grunhage D. Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. Mutation research,2003,540 (1):1-18.
[39]Yannai S, Day A J, Williamson G. Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines. Food and Chemical Toxicology,1998,36 (8):623-630.
[40]McPhail D B, Hartley R C, Gardner P T, et al. Kinetic and Stoichiometric Assessment of the Antioxidant Activity of Flavonoids by Electron Spin Resonance Spectroscopy. Journal of Agricultural and Food Chemistry,2003,51 (6):1684-1690.
[41]Von Moltke L L, Weemhoff J L, Bedir E, et al. Inhibition of human cytochromes P450 by components of Ginkgo biloba. The Journal of pharmacy and pharmacology,2004,56 (8): 1039-1044.
[42]邱声祥,柳叶白前化学成分研究.中国中药杂志,1994,19(8)：488-489.
[43]Wang Peng, Qin Hai-Lin, Zhang Ling, el al. Steroids from the roots of Cynanchum stauntonii. Planta Medica,2004,70 (11):1075-1079.
[44]NakagawaTakashi, Hayashi Koji. Mitsuhashi Hiroshi. Studies on the constituents of Asclepiadaceae plants. LV. The structures of three new glycosides, glaucoside-H,-I, and -J from the Chinese drug "Pai-ch'ien," Cynanchum glaucescens Hand-Mazz.. Chemical & Pharmaceutical Bulletin,1983,31(7):2244-2253.
[45]NakagawaTakashi, Hayashi Koji. Wada Keiji. et al. Studies on the constituents of Asclepiadaceae plants-LⅡ. The structures of five glycosides glaucoside A, B, C, D, and E from Chinese drug "Pai-ch'ien" Cyanchum glaucescens Hand-Mazz.. Tetrahedron,1983,39 (4): 607-612.
[46]Nakagawa Takash, Hayashi Koji, Mitsuhashi Hiroshi. Studies on the constituents of Asclepiadaceae plants. LIV. The structures of glaucoside-F and -G from the Chinese drug "Pai-ch'ien," Cynanchum glaucescens Hand-Mazz.. Chemical & Pharmaceutical Bulletin, 1983,31(3):879-882.
[47]魏金婷,刘文奇.植物药活性成分β-谷甾醇研究概况.莆田学院学报,2007,14(2)：38-41.
[48]梁爱华.芫花叶白前的镇咳、祛痰及平喘作用.中国中药杂志,1995,20(3)：176.
[49]梁爱华,薛宝云,杨庆,等.柳叶白前的镇咳、祛痰及抗炎作用.中国中药杂志,1996,21(3)：173-175.
[50]Yang Zai-Chang, Wang Bo-Chu, Yang Xiao-Sheng, et al. Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus. Colloids and Surfaces, B:Biointerfaces,2005,43 (3-4):198-202.
[51]赵宇.中药海蒿子多糖的分离纯化及结构研究.山东农业大学(自然科学版),2005,36(2)：247-250.
[52]刘新.中药复方海藻制剂药效物质基础的研究.中国海洋大学博士论文,2009,
[53]王景禄,胡永明,陆懋荪.中药海蒿子脂肪酸类成分分析.中国海洋药物,2001,140-41.
[54]Sadish Kumar S, Kumar Yatendra, Khan M S Y, et al. Antihistaminic, anticholinergic and antiviral activities of fucosterol from Turbinaria conoides (J.Agardh) kutzing. Pharmacologyonline, 2009,(1):1104-1112.
[55]Lee Yeon Sil, Shin Kuk Hyun, Kim Bak-Kwang, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa.. Archives of Pharmacal Research,2004,27(11):1120-1122.
[56]Lee Sanghyun, Lee Yeon Sil, Jung Sang Hoon, et al. Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa.. Archives of Pharmacal Research,2003,26 (9):719-722.
[57]Tang Hai-Feng, Yi Yang-Hua, Yao Xin-Sheng, et al. Bioactive steroids from the brown alga Sargassum carpophyllum.. Journal of Asian Natural Products Research,2002,4 (2):95-101.
[58]徐树楠,张美玉,王永梅,等.蝉蜕镇咳、祛痰、平喘作用的药理研究中国药理学通报.2007,23(12)：1678.
[59]陈奇.中药药理研究方法学(第2版).北京：人民卫生出版社,2006,630.
[60]杜勤,叶木荣,王振华,等.青天葵镇咳、平喘药理作用研究.广州中医药大学学报,2006,23(1)：45.
[61]Lu YH, Dai Y, Wang ZT, et al. The anti-tussive part and component of Aster Tataricus L. F. Chinese traditional and herbal drugs,1999,30(5):360-362.
[2]连炜,叶波平.海洋天然抗肿瘤活性产物的临床研究现状.药学进展,2009,33(05)：204-211.
[3]谭仁祥,杨玲.浅谈海洋药物研究与开发战略.中国新药杂志.2000,9(7)：27-31.
[4]涂洪斌,卫剑文,彭立胜,等.药用海洋生物功能基因组研究.世界科学技术-中药现代化.2001,3(4)：3-9.
[5]Lee K H. Scientific Chinese herbal medicine:research and movements toward worldwide acceptance. J. Food & Drug Anal,1997, (5):233-234.
[6]Lee K H. Research and future trends in the pharmaceutical development of medicinal herbs from Chinsese medicine. Public Health Nutrition,2000, (3):515-522.
[7]李经纬,林昭庚.中国医学通史(古代卷).北京：人民卫生出版社.2000,684.
[8]李玉清.略论李时珍对归经学说的贞献.天津中医学院学报,2003,22(1)：7.
[9]杨大坚.中药归经理论的形成及在方剂靶向疗效中的作用.中医药学刊,2005,23(9)：1708.
[10]高晓山.归经引经涵义和理论源流浅识.中药归经理论学术会议资料,1984,002E.
[11]王新陆.脑血辩证-中医理论发展的探索.北京：中国医药科技出版社.2002,35.
[12]孙晓波.对确定中药归经依据的探讨.广西中西药,1999,22(2)：42.
[13]严永清,吴建新.药物的辛味与归经作用及化学成分的关系.中药通报,1987,12(1)：531.
[14]吉阳,宋秀珍.“归经”理论渊源初探.吉林中医药,1999,9(1)：2.
[15]蓝石.中药归经涵义之我见.黑龙江中医药,1983,(2)：41.
[16]凌一揆.中药学.上海：上海科技出版社.1984,10.
[17]刘继林.中药归经的讨论.中医杂志,1981,(2)：63.
[18]马峰升.试谈中药归经.云南中医学院学报,1981,(1)：16.
[19]王世民,杨勇.中药归经学说浅谈.山西中医,1985,1(1)：42.
[20]印会河.中医基础理论(五版)上海：上海科技出版社.1984,56.
[21]焦一鸣,王放,金凌,等.24味致淤药的性味、归经和功能分析.中医文献杂志,1995,(2)：17-18.
[22]李兴广,刘梅.常用中药归经的计算机分析.中医杂志,1994,35(5)：313-315.
[23]金日光,牟雪雁.中药归经学说的本质—关于中药传统理论的当代化学物理及群子(量
子)统计理论的诠释(Ⅳ).世界科学技术—中医药现代化,2004,6(2)：15-20.
[24]陆光伟.中药归经及其成分在体内的分布.中成药研究,1984,(5)：38.
[25]郭顺根,牛建昭,贲长恩.3H-川芎嗪在动物体内分布的放射自显影研究.中国医药学报,1989,4(3)：17.
[26]陈文垲,黄玉芳,王海东,等.麝香“归经入脑”的实验研究.中西医结合学报,2004,2(4)：288-291.
[27]上海第一医学院.药理学.北京：人民卫生出版社.1979,
[28]贲长恩,郭顺根.中药归经理论研究述评.北京中医药大学学报,1999,22(2)：2-7.
[29]王健,黎晓敏,贾仁勇,等.368味兽用中药材的性味、归经、毒性与11种元素含量关系的研究.畜牧兽医学报,1997,28(1)：90-96.
[30]李心河,刘少平,高海青,等.313种中药35种无机元素含量的研究.山东医科大学学报,1994,32(2)：174-179.
[31]徐经采,朱梅年.明目中药的归经与微量元素的关系.微量元素,1987,(2)：23.
[32]龚跃新,张根海.中药归经理论与微量元素的关系探讨.中医药研究,1990,(5)：23.
[33]付先军.中药归经(肺经)理论和肺系方剂配伍规律的解析及在海洋中药研发中的应用：[博士学位论文].青岛：中国海洋大学医药学院.2009,90.
[34]郑广华.阴阳学说与环核苷酸.自然杂志,1979,2(4)：208.
[35]武密山,李恩,赵素芝,等.补肾复方对骨质疏松大鼠细胞内信息调节的影响及其与药物归经相关性的实验研究.上海中医药杂志,2000,46(2)：44-46.
[36]王树荣,孙冰,丁国明.中药归经的实验研究.中国中药杂志,1994,19(8)：500-502.
[37]王树荣,翟继伟,盖英臣.天麻、桔梗、元胡归经的实验研究.上海中医药杂志,1995,(1)：44.
[38]叶显纯.论“归经”.山东中医学院学报,1980,(4)：11.
[39]史正新.中药归经与受体学说.陕西中医学院学报,1993,16(2)：4.
[40]王海东.中药归经理论研究现状及受体学说关系的论证.浙江中医杂志,2001,36(8)：323-326.
[41]徐树楠.中药归经现代研究方法探讨.中国药理学通报,2004,20(5)：598-600.
[42]李仪奎,徐莲英,马建平.中药药理和归经关系的统计分析.中药通报,1988,13(7)： 48-50.
[43]高其铭.当归的药理研究与其归经功效关系的探讨.中成药研究,1985,(5)：13.
[44]曾秀池.试述中药归经的现代研究.实用中医药杂志,2004,20(3)：154-155.
[1]Ji Z H, Duyfjes BEE. Stemonaceae. In Flora of China. Beijing:Science Press.2000,70-72.
[2]国家药典委员会.中华人民共和国药典：一部.北京：化学工业出版社.2005,88.
[3]Pilli RA, Ferreira de Oliveira MC. Recent progress in the chemistry of the Stemona alkaloids. Nat. Prod. Rep,2000,17(1):117-127.
[4]Pilli RA, Giovanni B. Rosso, Maria Da Conceicao F. De Oliveira. The Stemona Alkaloids. The Alkaloids:Chemistry and Biology,2005,(62):77-173.
[5]Jiang Ren-Wang, Hon Po-Ming, Zhou Yan, et al. Alkaloids and Chemical Diversity of Stemona tuberosa. J Nat Prod.,2006,69 (5):749-754.
[6]Qian Jie, Zhan Zha-Jun. Novel alkaloids from Stemona sessilifolia. Helvetica Chimica Acta, 2007,90 (2):326-331.
[7]Chung Hoi-Sing, Hon Po-Ming, Lin Ge, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med,2003,69 (10):914-920.
[8]Ye Yang, Qin Guo-Wei, Xu Ren-Sheng. Alkaloids from Stemona tuberosa. Phytochemistry, 1994,37 (4):1201-1203.
[9]Johann Schinnerl, Elisabeth Kaltenegger, Thomas Pacher, et al. New Pyrrolo[1,2-a]azepine Type Alkaloids from Stemona and Stichoneuron (Stemonaceae). Monatshefte fuer Chemie,2005, 136(9):1671-1680.
[10]Xu Ren-Sheng. Some bioactive natural products from Chinese medicinal plants.Studies in Natural Products Chemistry. Bioactive Natural Products (Part B),2000,21 729-772.
[11]Lin Wen-Han, Fu Hong-Zheng. Three new alkaloids from the roots of Stemona tuberosa Lour. Journal of Chinese Pharmaceutical Sciences,1999,8 (1):1-7.
[12]Zou Chang-Ying, Fu Hong-Zheng, Lei Hai-Min, et al. New alkaloids from the roots of Stemona japonica Miq. Journal of Chinese Pharmaceutical Sciences,1999,8(4):185-190.
[13]Kakuta Daichi, Hitotsuyanagi Yukio, Matsuura Naofumi. Structures of new alkaloids sessilifoliamides A-D from Stemona sessilifolia. Tetrahedron,2003,59 (39):7779-7786.
[14]Lin Wen-Han, Ye Yang, Xu Ren-Sheng. Chemical studies on new Stemona alkaloids, Ⅳ. Studies on new alkaloids from Stemona tuberosa. J Nat Prod.,1992,55 (5):571-576.
[15]Jiang Ren-Wang, Hon Po-Ming. But Paul Pui-Hay, et al. Isolation and stereochemistry of two new alkaloids from Stemona tuberosa. Tetrahedron,2002,58 (33):6705-6712.
[16]Zhou Yan, Jiang Ren-Wang, Hon Po-Ming, et al. Analyses of Stemona alkaloids in Stemona tuberosa by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom, 2006.20(6):1030-1038.
[17]Cheng Dong-liang, Guo Jia, Chu Tze Tsin, et al. A study of Stemona alkaloids, Ⅲ. Application of 2D-NMR spectroscopy in the structure determination of stemoninine. J Nat Prod.. 1988.51 (2):202-211.
[18]Lin Li-Gen, Zhong Qiong-Xing, Cheng Tin-Yan, et al. Stemoninines from the Roots of Stemona tuberosa. J Nat Prod.,2006,69(7):1051-1054.
[19]Wang Peng, Liu Ai-Lin, Li Zhi-Hong, et al. Stemoninine-type alkaloids from the roots of Stemona sessilifolia. J Asian Nat Prod Res.,2008,10 (4):311-314.
[20]Lin Wen-Han, Ma Li, Cai Meng-Shen, et al. Two minor alkaloids from roots of Stemona tuberosa. Phytochemistry,1994,36(5):1333-1335.
[21]Kondo Heisaburo, Satomi Masakichi. Stemona alkaloids. Ⅻ. Alkaloids from the roots of Stemona japonica and Stemona sessilifolia. Yakugaku Zasshi,1947, (67):182-184.
[22]Wang Peng, Liu Ai-Lin, An Zheng, et al. Novel alkaloids from the roots of Stemona sessilifolia. Chem Biodivers..2007,4 (3):523-530.
[23]Ye Yang, Xu Ren-Sheng. Studies on new alkaloids of Stemona japonica. Chinese Chemical Letters,1992,3 (7):511-514.
[24]Ye Yang, Qin Guo-Wei, Xu Ren-Sheng. Alkaloids of Stemona japonica. Phytochemistry, 1994.37(4):1205-1208.
[25]Zou Chang-Ying, Li Jun, Lei Hai-Min, et al. A new alkaloid from root of Stemona japonica Miq.. Journal of Chinese Pharmaceutical Sciences,2000,9 (3):113-115.
[26]Lin LG, Li KM, Tang CP, et al. Antitussive Stemoninine Alkaloids from the Roots of Stemona tuberosa. J. Nat. Prod.,2008,71 (6):1107-1110.
[27]Jiang Ren-Wang, Hon Po-Ming, Xu Yan-Tong, et al. Isolation and chemotaxonomic significance of tuberostemospironine-type alkaloids from Stemona tuberosa. Phytochemistry,2006, 67(1):52-57.
[28]Xu Ren-Sheng. Lu Yong-Jun. Chu Jen-Hun, et al. Studies on some new Stemona alkaloids. A diagnostically useful proton NMR line-broadening effect. Tetrahedron,1982,38(17):2667-2670.
[29]Sakata Kanzo, Aoki Katsuyuki, Chang Ching-Fung, et al. Stemospironine, a new insecticidal alkaloid of Stemona japonica Miq., isolation, structural determination and activity. Agricultural and Biological Chemistry,1978,42 (2):457-463.
[30]Lu Li-Hua, Ye Wen-Cai, Zhao Shou-Xun, et al. Chemical constituents of Stemona sessilifolia. Zhongguo Yaoke Daxue Xuebao,2005,36 (5):408-410.
[31]Ye Yang, Qin Guo-Wei, Xu Ren-Sheng. Studies on Stemona alkaloids. Ⅵ. Alkaloids of Stemona japonica. J Nat Prod.,1994,57 (5):665-669.
[32]Iizuka Hisho, Irie Hiroshi, Masaki Norior, et al. X-ray crystallographic determination of the structure of stemonamine. A new alkaloid from Stemona japonica. Isolation of isostemonamine. Journal of the Chemical Society, Chemical Communications,1973, (4):125-126.
[33]Wang Peng, Qin Hai-Lin, Li Zhi-Hong, et al. A new alkaloid from Stemona sessilifolia. Chinese Chemical Letters,2007,18 (2):152-154.
[34]Hitotsuyanagi Yukio, Hikita Maho, Oda Takahisa, et al. Structures of four new alkaloids from Stemona sessilifolia. Tetrahedron,2007,63 (4):1008-1013.
[35]Hitotsuyanagi Yukio, Hikita Maho, Nakada Kazuhiro, et al. Sessilifoliamide I, a new alkaloid from Stemona Sessilifolia. Heterocycles,2007,71 (9):2035-2040.
[36]H. Shinozaki, M. Ishida. Inhibitory actions of tuberostemonine on the excitatory transmission at the crayfish neuromuscular junction. Brain Research,1985,334 (1):33-40.
[37]Liu Zhi-Long, Goh Swee Hock, Ho Shuit Hung. Screening of Chinese medicinal herbs for bioactivity against Sitophilus zeamais Motschulsky and Tribolium castaneum (Herbst). Journal of Stored Products Research,2007,43 (3):290-296.
[38]Brigitte Brem, Christoph Seger, Thomas Pacher, et al. Feeding Deterrence and Contact Toxicity of Stemona Alkaloids-A Source of Potent Natural Insecticides. J. Agric. Food Chem, 2002,50 (22):6383-6388.
[39]Xu Yan-Tong, Hon Po-Ming, Jiang Ren-Wang, et al. Antitussive effects of Stemona tuberosa with different chemical profiles. J Ethnopharmacol,2006,108 (1):46-53.
[40]Yang Xin-Zhou, Zhu Jian-Yu, Tang Chun-Ping, et al. Alkaloids from roots of Stemona sessilifolia and their antitussive activities. Planta medica.2009,75 (2):174-177.
[41]Liao Jyh-Fei, Shi Chuen-Chao, Chen Su-Ying, et al. Spasmolytic effect of water extract of Stemonae radix on the guinea-pig tracheal smooth muscle in vitro. J Ethnopharmacol,1997,57 (1): 57-62.
[42]Rinner Beate, Siegl Veronika. Purstner Peter, et al. Activity of novel plant extracts against medullary thyroid carcinoma cells. Anticancer research,2004,24 (2A):495-500.
[43]王锋鹏.生物碱化学.北京：化学工业出版社.2008,19-29.
[44]丛晓东,徐国钧,金蓉鸾,等.百部生药学研究Ⅸ.中国百部属植物块根中总生物碱的测定与评估.药学学报,1992,27(7)：556-560.
[45]Li Song-Lin, Jiang Ren-Wang, Hon Po-Ming, et al. Quality evaluation of Radix Stemonae through simultaneous quantification of bioactive alkaloids by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. Biomed Chromatogr.,2007,21 (10):1088-1094.
[46]夏敏.必需微量元素的生理功能.微量元素与健康研究,2003,20(3)：41-44.
[47]何培之,王世驹,李续娥.普通化学.北京：科学出版社.2001,372-379.
[48]卢金清,黄芳,蒋胜军,等.金菊花中微量元素和氨基酸的含量分析.湖北中医学院学报,2006.8(1)：39-40.
[49]付先军.中药归经(肺经)理论和肺系方剂配伍规律的解析及在海洋中药研发中的应用：[博士学位论文].青岛：中国海洋大学医药学院.2009,90.
[50]陈月开.半胱氨酸的抑菌作用与类SOD活力.山西大学学报(自然科学版),2004,27(1)：65-67.
[51]张建新,李立萍,董淑婷,等.L-精氨酸对大鼠内毒素性肺损伤治疗作用的研究.中国药科大学学报.2004,35(4)：349-352.
[52]曾静,罗海吉.张勇,等.L-精氨酸对热应激小鼠胸腺T细胞业群的影响.热带医学杂志,2003,3(2)：155-157.
[53]Barbul Adrian. Wasserkrug Hannah L., Seifter Eli, et al. Immunostimulatory effects of arginine in normal and injured rats. Journal of Surgical Research,1980,29 (3):228-235.
[54]程俊文,吴学谦,孙培虎,等.灵芝多糖提取物胶囊对小鼠免疫功能的影响.中国食用菌,2009,28(6)：41-44.
[55]乔进,薛华,孟国梁,等.灵芝多糖对2型糖尿病大鼠胸主动脉内皮功能的保护作用.中国动脉硬化杂志,2009.17(9)：709-713.
[56]张勇,刘小玲,刘小雷.红景天多糖体外抗CVB3病毒活性.中国医院药学杂志,2009, 29(20)：1749-1753.
[57]龚海英,李建宇,梁林,等.枸杞多糖对神经元缺氧损伤的保护作用.武警医学院学报.2009,18(12)：1002-1017.
[58]王希玉,路莉,胡燕,等.不同红芪多糖抗肿瘤和免疫调节作用研究.中药药理与临床.2009,25(5)：72-74.
[59]陈永,安洪庆,宋利,等.红毛五加多糖中单糖组成的气相色谱分析.江苏中医药,2008,40(1)：65-66.
[60]大连轻工业学院.食品分析.北京：中国轻工业出版社.1994,177-180.
[61]李铁林,吴昌贤,张燕霞.糖和糖醇的气相色谱分析研究：Ⅱ.糖腈乙酰酯衍生物气相色谱分析的改进.分析化学,1982,10(5)：272.
[62]武汉大学.仪器分析.北京：高等教育出版社.2002,379.
[63]Cheng Donglian, Guo Jia, Chu Tze Tsin, et al. A STUDY OF STEMONA ALKALOIDS, III. APPLICATION OF 2D-NMR SPECTROSCOPY IN THE STRUCTURE DETERMINATION OF STEMONININE. Journal of Nature Products,1988,51(2):202-211.
[64]潘坚扬,赵筱萍,邵青.丹参素大鼠体内药代动力学及生物利用度研究.中国中药杂志,2008,33(2)：146-149.
[65]陈淑娟,杨毅梅,刘奕明,等.蝙蝠葛碱大鼠体内药物代谢动力学研究.中国药理学通报,2001,17(2)：225-229.
[66]张海防,郭健新,黄罗生,等.羟基红花黄色素A在大鼠体内的药代动力学.中国药科大学学报,2006,37(5)：456-460.
[67]顾轶,王广基,孙建国,等LC-MS法测定Beagle犬血浆中人参皂苷20(R)-Rh2及其药代动力学研究.中国临床药理学与治疗学,2006,11(3)：256-260.
[68]李静,王广基.药物胃肠道吸收屏障及新型促吸收方法.药学学报,2005,40(7)：600.
[69]Leung Pak Ho Henry. Chemical, pharmacological and intestinal absorption studies of Stemona alkaloids from Radix Stemonae[博士学位论文].香港：香港中文大学.2006.
[1]陈潮祖.中医治法与方剂.北京：人民卫生出版社.1995,245.
[2]林琳,罗细贞,张忠德.止嗽散加减治疗外感咳嗽证392例临床分析.按摩与引导,1999,15(5)：53-54.
[3]李景昌.止嗽散加味治疗老年性肺部感染89例.新中医,2000,32(7)：58-59.
[4]许轶兰.止嗽散加减治疗慢性支气管炎30例.中原医刊,1994,21(5)：44.
[5]徐雯.止嗽散为主治疗小儿支原体肺炎18例.浙江中医杂志,1997,32(12)：543.
[6]陈允旺,陈丽华.加味止嗽散治疗顽固性干咳50例-附西药治疗30例对照.黑龙江中医药,2002,(5)：27-28.
[7]冯桂贞,杨宜中,朱芳富.加味止嗽散治疗间质性肺炎30例.四川中医,1995,13(6)：29.
[8]陈秀虹.麻蝉止嗽散治疗百日咳.浙江中医学院学报,1994,18(3)：11.
[9]王志云,赵国云.加味止嗽散治疗百日咳40例.陕西中医,1994,15(8)：368.
[10]秦芝芳.代赭止嗽散加味治疗外感咳嗽疗效观察.河北中医,2000,22(8)：591.
[11]刘蕾,代立娟,赵玉珍,等.荆芥百部合剂药效学实验研究.黑龙江医药科学,2005,28(1)：33-34.
[12]徐乃玉.加味止嗽散平喘作用及其机制实验研究.[硕士学位论文],苏州：苏州大学,2003.
[13]Xu Yan-Tong, Hon Po-Ming, Jiang Ren-Wang, et al. Antitussive effects of Stemona tuberosa with different chemical profiles. J Ethnopharmacol,2006,108(1):46-53.
[14]Lin LG, Li KM, Tang CP, et al. Antitussive Stemoninine Alkaloids from the Roots of Stemona tuberosa. J. Nat. Prod.,2008,71 (6):1107-1110.
[15]Jiang Ren-Wang, Hon Po-Ming, Zhou Yan, et al. Alkaloids and chemical diversity of Stemona tuberosa. J Nat Prod,2006,69 (5):749-754.
[16]Chung Hoi-Sing, Hon Po-Ming, Lin Ge, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med,2003,69 (10):914-920.
[17]Takagi K, Lee E. B. Pharmacological studies on Platycodonrandiflorum A. DC. Yakgaku zasshi,1972,92 (8):969-973.
[18]Shin C. Y., Lee W. J., Lee E. B. Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters. PlantaMed,2002,68 (3):221-225.
[19]Lin N, Sato T, Takayama Y, et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblast and mouse macrophages. Biochem plarmacol,2003,65 (12):2065.
[20]卞如谦,杨秋水,任熙云,等.荆芥油的药理研究.浙江医科大学学报,1981,10(5)：219.
[21]郑虎占,董泽宏,佘靖.中药现代研究与应用.北京：学苑出版社.1999,3072.
[22]贺平,贾随旺,吴孟超,等.小鼠甘草酸的药代动力学及其与人血装蛋白结合率.中国药理学通报,1998,14(1)：89.
[23]吕小华,吴铁,覃冬云.甘草酸对哮喘小鼠一氧化氮及一氧化氮合酶的影响.时珍国医国药,2009,20(1)：40-41.
[24]Fu N W, Liu Z Y, Zhang R Y, et al. Studies from Glycyrrhiza Pharmacol Clin Chin Mater Med,1994, (5):26-29.
[25]娄红祥,李铣,朱廷儒.华北白前中的C21甾体类化合物.药学学报,1992,27(8)：595-602.
[26]龚小见.柳叶白前和多毛板凳果的化学成分研究.贵州大学硕士论文,2006.
[27]魏金婷,刘文奇.植物药活性成分β-谷甾醇研究概况.莆田学院学报,2007,14(2)：38-41.
[28]梁爱华.芫花叶白前的镇咳、祛痰及平喘作用.中国中药杂志,1995,20(3)：176.
[29]梁爱华,薛宝云,杨庆,等.柳叶白前的镇咳、祛痰及抗炎作用.中国中药杂志,1996,21(3)：173-175.
[30]吴坚东.板蓝根注射液在家兔体内药代动力学的评价.中成药研究,1993,15(3)：5.
[31]徐凯建,孙考祥,陆义成,等.“双黄连”注射剂与气雾剂的人体生物利用度研究.中国医院药学杂志,1992,12(11)：484.
[32]张志荣,胡晓颖,蒋大义,等.银黄冲剂中黄芩苷在家兔体内的代谢动力学研究.中成药研究,1996,18(6)：1.
[33]周莉玲,李锐,魏敏,等.丁公藤注射液的药动学相关性研究.中成药研究,1999,21(9)：439-440.
[34]富杭育,贺玉琢,周爱香.以解热的药效法初探麻黄汤、桂枝汤、银翘散、桑菊饮的药代动力学.中药药理与临床,1992,8(1)：1-7.
[35]富杭育,贺玉琢,周爱香.以发汗的药效法初探麻黄汤、桂枝汤、银翘散、桑菊饮的药 代动力学.中药药理与临床,1992,8(5)：1-5.
[36]贺玉琢,富杭育,周爱香.以抗炎的药效法再探麻黄汤、桂枝汤、银翘散、桑菊饮的药代动力学.中药药理与临床,1993,9(1)：1-4.
[37]富杭育,周爱香,贺玉琢.以抑制肠蠕动亢进作用再探麻黄汤、桂枝汤、银翘散、桑菊饮的药代动力学.中成药,1993,15(1)：35-36.
[38]赵智强,王小勤,陆跃鸣,等.镇肝熄风汤与天麻钩藤饮对小鼠自发活动抑制作用的药效动力学研究.中药药理与临床,1996,12(6)：23-25.
[39]赵智强,陆跃鸣,俞晶华,等.天麻钩藤饮等三方抗小鼠惊厥的药效动力学研究.中药药理与临床,1998,14(6)：4-6.
[40]赵智强,陆跃鸣,周仲瑛,等.天麻钩藤饮等三方对高血压大鼠模型降压作用的药效动力学研究.中药药理与临床,1999,15(4)：12-13.
[41]赵智强,陆跃呜,俞晶华,等.天麻钩藤饮等三方对小鼠自发活动效应的药效动力学研究.中药药理与临床,1999,15(1)：6-7.
[42]周京滋,陈长勋,苏健美,等.附子、四逆汤镇痛、抗炎作用的药效动力学研究.中国中药杂志,1992,17(2)：101.
[43]刘延福,赵福民,周毅生,等.小活络丸镇痛药效成分的药物动力学研究.中成药,1994,16(3)：34.
[44]卢贺起,张智,魏雅力,等.以药效法测定四物汤药动学参数的研究.中药药理与临床,1995,11(1)：11.
[45]任天池,王玉蓉,曾立品,等.用药物积累法考察九分散和疏风定痛丸的药物动力学实验.中成药,1991,13(7)：2.
[46]阴健,任天池,曹春林.黄芩苷及其在清开灵注射液中的药代动力学研究.中国实验方剂学杂志,1998,4(4)：31.
[47]常明向,徐莲英,陶建生.当归及其配伍对当归芍药汤的药动学研究.中药药理与临床,1992,8(4)：34.
[48]王晖,许卫铭,王宗锐.薄荷醇对柴胡镇痛成分表观生物利用度的影响.中成药,1996,18(6)：4-6.
[49]Yang Xiao-Ning, Wang Yan-Jiao, Liu Yu-Shi, et al. Pharmacokinetics of salvianolic acids after intravenous injection, with and without Panax quinquefolium protopanaxadiol saponins, in rats. Journal of ethnopharmacology,2008,117:408-414.
[50]沈群.麻黄汤不同配伍对麻黄碱和伪麻黄碱在小鼠体内药代动力学的影响.[硕士学位论文],广州：第一军医大学,2002.
[1]管华诗.我国海洋创新药物的研究和开发.中国天然药物,2006,4(1)：1.
[2]国家药典委员会.中华人民共和国药典(2005年版).北京：化学工业出版社.2005.
[3]徐国钧,王强.中草药彩色图谱.福州：福建科学技术出版社.2006,380-401.
[4]王巧玲.贾绍华.川陈皮素抗癌作用及机制的研究进展中草药,2009,40 40-42.
[5]Manthey J A, Guthrie N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J Agric Food Chemistry,2002,50 (21):5837-5843.
[6]Rodiiguez J, Yanez J, Vicente V, et al. Effects of several flavonoids on the growth of B16F10 and SK·MEL-1 melanoma cell lines:relationship between structure and activity. Melanoma Res, 2002,2(12):99-107.
[7]Kawaii S, Tomono Y, Katase E, et al. Effect of citrus flavonoids on HL-60 cell differentiation. Anticancer Res,1999,2A (19):0250-7005.
[8]Satoru K, Yasuhiko T, Eriko K, et al. Antiproliferative activity of flavonoidson several cancer cell lines. Biosci Biotechnol Biochem,1999,63(5):896-899.
[9]Bracke M, Vyncke B, Opdenakker G, et al. Effect of catechins and citrus flavonoids on invasionin vitro. Clin Exp Metastasis,1991,9 13-25.
[10]Takashi S, Leona K. Yoshiki M, et al. Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metallo-proteinases-1 and-9 in human fibrosarcoma HT-1080 cells. Cancer Res,2002, 62(4):1025-1029.
[11]Minagawa A, Otani Y, Kubota T. et al. The citrus flavonoid, nobiletin inhibit peritoneal dissemination of human gastric carcinoma in SCID mice. Jpn J Cancer Res,2001,92(12): 1322-1328.
[12]Garg A. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res, 2001,15 (2):655.
[13]季宇彬.中药有效成分药理与应用.哈尔滨：黑龙江科技出版社,1995,254.
[14]徐任生,叶阳,赵维民.天然产物化学.北京：科学出版社.2006,562-564.
[15]彭丽莎,方俊,孟德连,等.橙皮苷对病原微生物的影响.现代农业科技.2006,(10)：18-19.
[16]孙文基.天然活性成分简明手册.北京：中国医药科技出版社.1998,292.
[17]中国医学科学院药物研究所.中草药有效成分的研究.北京：人民卫生出版社.1972,396.
[18]娄桂予,江渝,彭家和.橙皮甙抗LDL氧化及对MCP-1mRNA转化的影响.第三军医大学学报,2004,26(8)：717-719.
[19]秦得安,王晓玲.橙皮苷对羟自由基的清除作用.中国药学杂志,1996,31(7)：390.
[20]秦得安,王晓玲.橙皮苷对羟自由基引发红细胞膜损伤的影响.中国药学杂志,1996,31(7)：396-398.
[21]李荣,李俊,胡成穆,等.橙皮苷对免疫功能低下小鼠免疫调节作用的实验研究.中国药理学通报,2007,23(2)：169-172.
[22]FernA Andez SebastiAAn P., W asowski Cristina, PaladiniAlejandro C, et al. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. European Journal ofPharmacology,2005,512 (2-3):189-198.
[23]T. Tanaka. Chemoprevention of human cancer:biology and therapy. Crit Rev. Oncol. /Hematol,1997,25 139-174.
[24]S.V. Jovanovic, S. Steenken, M. Tosic, et al. Simic Flovoniods as Antioxidants. J. Am. Chem. Soc,1994,116 4846.
[25]张秀尧,凌罗庆,毛泉明.西河柳化学成分的研究.中草药,1991,22(7)：229-230.
[26]张秀尧,凌罗庆,毛泉明.西河柳化学成分的研究.中草药,1989,20(8)：4-5.
[27]许福泉.柽柳和萹蓄归经的比较研究.中国海洋大学博士论文,2009,
[28]王斌.黄河三角洲滨海湿地药用耐盐植物蒙古鸦葱和柽柳化学成分及生物活性研究.[博士学位论文],青岛：中国海洋大学,2007.
[29]宋霞林,黄子君.西河柳槲皮素和异鼠李素在植物体内分布及随季节变化.中国药师,2007,10(5)：459-461.
[30]姜岩清,左春旭.柽柳化学成分的研究.药学学报,1988,23(10)：749-755.
[31]Yang L L, Yen K Y, Kiso Y, et al. Antihepatotoxic actions of Formosan plant drugs. Journal of ethnopharmacology,1987,19 (1):103-110.
[32]吴慧英.西河柳治痹.江西中医药,1996,(增刊)：94.
[33]赵润洲,孙仕银,陈发奎,等.西河柳药理作用的研究.中草药,1995,26(2)：85.
[34]张媛,屠鹏飞.柽柳属药用植物研究进展.中草药,2008,39(6)：947-951.
[35]Sultanova N. Makhmoor T, Abilov Z A. et al. Antioxidant and antimicrobial activities of Tamarix ramosissima. Journal of ethnopharmacology,2001,28 (2-3):201-205.
[36]Fazilatun N, Nornisah M, Zhari I. Superoxide radical scavenging properties of extracts and flavonoids isolated from the leaves of Blumea balsamifera. Pharmaceutical Biology.2005,43 (1): 15-20.
[37]Nessa F, Ismail Z, Mohamed N. Free radical-scavenging activity of organic extracts and of pure flavonoids of Blumea balsamifera DC leaves. Food Chemistry,2004,88 (2):243-252.
[38]Edenharder R, Grunhage D. Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. Mutation research,2003,540 (1):1-18.
[39]Yannai S, Day A J, Williamson G. Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines. Food and Chemical Toxicology,1998,36 (8):623-630.
[40]McPhail D B, Hartley R C, Gardner P T, et al. Kinetic and Stoichiometric Assessment of the Antioxidant Activity of Flavonoids by Electron Spin Resonance Spectroscopy. Journal of Agricultural and Food Chemistry,2003,51 (6):1684-1690.
[41]Von Moltke L L, Weemhoff J L, Bedir E, et al. Inhibition of human cytochromes P450 by components of Ginkgo biloba. The Journal of pharmacy and pharmacology,2004,56 (8): 1039-1044.
[42]邱声祥,柳叶白前化学成分研究.中国中药杂志,1994,19(8)：488-489.
[43]Wang Peng, Qin Hai-Lin, Zhang Ling, el al. Steroids from the roots of Cynanchum stauntonii. Planta Medica,2004,70 (11):1075-1079.
[44]NakagawaTakashi, Hayashi Koji. Mitsuhashi Hiroshi. Studies on the constituents of Asclepiadaceae plants. LV. The structures of three new glycosides, glaucoside-H,-I, and -J from the Chinese drug "Pai-ch'ien," Cynanchum glaucescens Hand-Mazz.. Chemical & Pharmaceutical Bulletin,1983,31(7):2244-2253.
[45]NakagawaTakashi, Hayashi Koji. Wada Keiji. et al. Studies on the constituents of Asclepiadaceae plants-LⅡ. The structures of five glycosides glaucoside A, B, C, D, and E from Chinese drug "Pai-ch'ien" Cyanchum glaucescens Hand-Mazz.. Tetrahedron,1983,39 (4): 607-612.
[46]Nakagawa Takash, Hayashi Koji, Mitsuhashi Hiroshi. Studies on the constituents of Asclepiadaceae plants. LIV. The structures of glaucoside-F and -G from the Chinese drug "Pai-ch'ien," Cynanchum glaucescens Hand-Mazz.. Chemical & Pharmaceutical Bulletin, 1983,31(3):879-882.
[47]魏金婷,刘文奇.植物药活性成分β-谷甾醇研究概况.莆田学院学报,2007,14(2)：38-41.
[48]梁爱华.芫花叶白前的镇咳、祛痰及平喘作用.中国中药杂志,1995,20(3)：176.
[49]梁爱华,薛宝云,杨庆,等.柳叶白前的镇咳、祛痰及抗炎作用.中国中药杂志,1996,21(3)：173-175.
[50]Yang Zai-Chang, Wang Bo-Chu, Yang Xiao-Sheng, et al. Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus. Colloids and Surfaces, B:Biointerfaces,2005,43 (3-4):198-202.
[51]赵宇.中药海蒿子多糖的分离纯化及结构研究.山东农业大学(自然科学版),2005,36(2)：247-250.
[52]刘新.中药复方海藻制剂药效物质基础的研究.中国海洋大学博士论文,2009,
[53]王景禄,胡永明,陆懋荪.中药海蒿子脂肪酸类成分分析.中国海洋药物,2001,140-41.
[54]Sadish Kumar S, Kumar Yatendra, Khan M S Y, et al. Antihistaminic, anticholinergic and antiviral activities of fucosterol from Turbinaria conoides (J.Agardh) kutzing. Pharmacologyonline, 2009,(1):1104-1112.
[55]Lee Yeon Sil, Shin Kuk Hyun, Kim Bak-Kwang, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa.. Archives of Pharmacal Research,2004,27(11):1120-1122.
[56]Lee Sanghyun, Lee Yeon Sil, Jung Sang Hoon, et al. Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa.. Archives of Pharmacal Research,2003,26 (9):719-722.
[57]Tang Hai-Feng, Yi Yang-Hua, Yao Xin-Sheng, et al. Bioactive steroids from the brown alga Sargassum carpophyllum.. Journal of Asian Natural Products Research,2002,4 (2):95-101.
[58]徐树楠,张美玉,王永梅,等.蝉蜕镇咳、祛痰、平喘作用的药理研究中国药理学通报.2007,23(12)：1678.
[59]陈奇.中药药理研究方法学(第2版).北京：人民卫生出版社,2006,630.
[60]杜勤,叶木荣,王振华,等.青天葵镇咳、平喘药理作用研究.广州中医药大学学报,2006,23(1)：45.
[61]Lu YH, Dai Y, Wang ZT, et al. The anti-tussive part and component of Aster Tataricus L. F. Chinese traditional and herbal drugs,1999,30(5):360-362.
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