两种钼钨多酸抑制肿瘤细胞活性研究
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摘要
多金属氧酸盐(POMs)是一类具有丰富拓扑结构和性质的簇合物,由于在催化、吸附、光化学、电磁、医疗等领域有广泛的应用,引起人们广泛的研究兴趣。很多研究小组都以多酸作为无机构筑单元,利用有机及有机金属或过渡金属复合物对其结构进行修饰,并通过低温水热合成技术得到了一些结构新颖、功能独特的无机-有机杂化材料。
本文以合成的3-(2-吡啶基)吡唑(L)作为有机配体,以[Mo8O26]4-为无机构筑单元,通过3-(2-吡啶基)吡唑、(NH4)2Mo4O13·2H2O和NiCl2·6H2O的低温水热反应,合成了1种新型化合物:[Ni(C8N3H7)3]4[Mo8O26]2·7H2O(1),晶体结构通过X-射线单晶衍射确定。化合物1具有一种新型的三维超分子结构,而且是以3-(2-吡啶基)吡唑作为配体,和经典的[Mo8O26]4-形成的首个具有一维孔道的三维蜂窝状超分子网状结构,且分子中同时具有α-和β-[Mo8O26]4-结构单元。同时建立乳腺癌、卵巢癌和肺癌等细胞的体外培养模型,研究部分多酸化合物和合成的多酸分子的体外抗肿瘤活性。
Polyoxometalates(POMs) have recently been attracting extensive interest in solid state materials chemistry due to their fascinating properties and great potential applications in many fields such as catalysis, material science, medicine, and magnetochemistry. Polyoxometalates(POMs) as one kind of significant metal oxide clusters with nanosizes and abundant topologies have recently been employed as inorganic building blocks for the construction of new materials. In particular, the chemistry of coordination compounds of polyoxometalates with organic ligands provides knowledge about the interaction of small organic molecules with polyoxometalates surface.
In this paper, we used the L ligand and octamolybdate as structural building blocks, reaction of 3-(2-pyridyl)pyrazol with (NH4)2Mo4O13·2H2O and NiCl2·6H2O afforded the complex: [Ni(C8N3H7)3]4[Mo8O26]2·7H2O(1), crystal structure was characterized by using X-ray single–crystal diffraction. Compound(1) is with a novel three-dimensional supramolecular structure. This is hitherto the example observed that the L ligand was used to construct a three-dimensional honeycomb‘host’supramolecular network with one-dimensional channels,in whichα- andβ-octamolybdate anions‘guest’reside. The tumor growth inhibition activity of some compounds including [Ni(C8N3H7)3]4[Mo8O26]2·7H2O on breast,ovary and lung cancer were measured by cell culturing and interfering in vitro.
本文以合成的3-(2-吡啶基)吡唑(L)作为有机配体,以[Mo8O26]4-为无机构筑单元,通过3-(2-吡啶基)吡唑、(NH4)2Mo4O13·2H2O和NiCl2·6H2O的低温水热反应,合成了1种新型化合物:[Ni(C8N3H7)3]4[Mo8O26]2·7H2O(1),晶体结构通过X-射线单晶衍射确定。化合物1具有一种新型的三维超分子结构,而且是以3-(2-吡啶基)吡唑作为配体,和经典的[Mo8O26]4-形成的首个具有一维孔道的三维蜂窝状超分子网状结构,且分子中同时具有α-和β-[Mo8O26]4-结构单元。同时建立乳腺癌、卵巢癌和肺癌等细胞的体外培养模型,研究部分多酸化合物和合成的多酸分子的体外抗肿瘤活性。
Polyoxometalates(POMs) have recently been attracting extensive interest in solid state materials chemistry due to their fascinating properties and great potential applications in many fields such as catalysis, material science, medicine, and magnetochemistry. Polyoxometalates(POMs) as one kind of significant metal oxide clusters with nanosizes and abundant topologies have recently been employed as inorganic building blocks for the construction of new materials. In particular, the chemistry of coordination compounds of polyoxometalates with organic ligands provides knowledge about the interaction of small organic molecules with polyoxometalates surface.
In this paper, we used the L ligand and octamolybdate as structural building blocks, reaction of 3-(2-pyridyl)pyrazol with (NH4)2Mo4O13·2H2O and NiCl2·6H2O afforded the complex: [Ni(C8N3H7)3]4[Mo8O26]2·7H2O(1), crystal structure was characterized by using X-ray single–crystal diffraction. Compound(1) is with a novel three-dimensional supramolecular structure. This is hitherto the example observed that the L ligand was used to construct a three-dimensional honeycomb‘host’supramolecular network with one-dimensional channels,in whichα- andβ-octamolybdate anions‘guest’reside. The tumor growth inhibition activity of some compounds including [Ni(C8N3H7)3]4[Mo8O26]2·7H2O on breast,ovary and lung cancer were measured by cell culturing and interfering in vitro.
引文
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