玉蝉卫肺丸治疗变应性鼻炎肺脾气虚证的临床研究
|
摘要
变应性鼻炎是耳鼻喉科的常见病,属中医“鼻鼽”范畴。近年来,尽管对鼻变态反应的研究和防治有了较大进展,但该病仍未得到有效控制。中医对本病的认识有着独特的理论体系,治疗上强调整体观念和辨证论治,取得了满意的临床疗效。本课题针对肺脾气虚证变应性鼻炎的患者以玉蝉卫肺丸作为治疗用药,进行客观系统的分析研究。
研究目的
客观评价玉蝉卫肺丸治疗变应性鼻炎肺脾气虚证的临床疗效及安全性。研究方法
将150例符合变应性鼻炎肺脾气虚证的患者按2：1随机分为治疗组和对照组。治疗组患者口服玉蝉卫肺丸,对照组患者口服盐酸西替利嗪片。观察患者用药前后及随访期主观症状、客观指标的变化情况。
研究结果
1、症候综合疗效的评价,在FAS中,治疗组和对照组的等级疗效差别有统计学意义,治疗组优于对照组(P<0.05)；在PPS中,两组的等级疗效差别无统计学意义(P>0.05)。这是由于Fas的样本含量多于PPS, PPS中脱落病例的原因为使用对照药无效,患者要求改为中药治疗。
2、治疗期单项症状变化分析,两组的鼻塞、喷嚏、嗅觉减退症状、鼻粘膜肿胀的变化在统计学上无差异(P>0.05),流涕变化治疗组明显优于对照组(P<0.01),鼻痒及鼻腔分泌物变化治疗组优于对照组(P<0.05)。
3、治疗组和对照组在随访期鼻塞、流涕、喷嚏的变化,治疗组优于对照组,说明中药疗效的持续性要优于对照组。
4、研究过程中,治疗组患者用药期间及用药后1月,均未发现不良事件。
结论
1、玉蝉卫肺丸具有补益肺脾,益气固表,祛风止痒,止嚏敛涕,通利鼻窍,,抗过敏的功效。
2、玉蝉卫肺丸治疗肺脾气虚证变应性鼻炎具有很好的临床疗效及安全性。
Allergic rhinitis(AR) is a common otorhinolaryngologic disease, belongs to "Bi Qiu" category in Chinese medicine. Although the studies and treatments on nasal allergic have made great progress, but the AR has not been effectively controlled. Chinese medicine has a unique theoretical system for the AR, it emphasized the holism and differentiation treatment, and achieved satisfactory clinical curative effect. The paper is to objectively and systematically research Allergic rhinitis with lung spleen deficiency syndrome, by analyzing the patients who take Yu Chan Wei Fei pill as a treatment medicine.
Objective
To evaluate objectively the curative effect and safety of Yu Chan Wei Fei pill in treating allergic rhinitis with lung spleen deficiency syndrome.
Methods
150 patients of allergic rhinitis with lung spleen deficiency syndrome were randomly divided into treatment and control groups, by ratio 2:1. Treatment group patients were treated with Yu Chan Wei Fei pill, control group patients were treated with cetirizine hydrochloride tablet. The patients were observed their subjective symptoms and physical sign of change before and after treatment.
Results
1. Symptom comprehensive evaluation of curative effect. In FAS, the difference in level of curative effect of treatment group and control group is statistically significant. The curative effect of treatment group is better than control group (P<0.05). In PPS, the difference in level of curative effect of two groups was not statistically significant (P> 0.05). This is because that the samples of FAS were more than PPS. The reason for PPS samples'leave was the drugs ineffective of controlled groups, hence the patient asked to treat by traditional Chinese medicine.
2. Changes analysis of individual symptoms during the treatment. The changes in nasal obstruction, sneezing, hyposmia symptoms, and nasal swelling of two groups were not statistical difference (P> 0.05). The treatment group of rhinorrhea was better than control group obviously(P<0.01). The treatment group of nasal itching and nasal discharge was better than the control group (P<0.05).
3. Changes analysis of nasal obstruction, runny nose, sneezing during follow up phase. The treatment group was better than the control group, which indicated that the continued curative effect of Chinese medicine is better than the control group.
4. Adverse events were not found in treatment group, during treatment and after one month of treatment
Conclusion
1. Yu Chan Wei Fei pill can tonify the lung and the spleen, replenish Qi and secure the exterior, dispel wind and itching, stop sneezing and rhinorrhea. It has the effect of relieving the stuffy nose, and anti-allergic effect.
2. Yu Chan Wei Fei Pill has a good clinical efficacy and safety, when treating allergic rhinitis with lung spleen deficiency syndrome.
研究目的
客观评价玉蝉卫肺丸治疗变应性鼻炎肺脾气虚证的临床疗效及安全性。研究方法
将150例符合变应性鼻炎肺脾气虚证的患者按2：1随机分为治疗组和对照组。治疗组患者口服玉蝉卫肺丸,对照组患者口服盐酸西替利嗪片。观察患者用药前后及随访期主观症状、客观指标的变化情况。
研究结果
1、症候综合疗效的评价,在FAS中,治疗组和对照组的等级疗效差别有统计学意义,治疗组优于对照组(P<0.05)；在PPS中,两组的等级疗效差别无统计学意义(P>0.05)。这是由于Fas的样本含量多于PPS, PPS中脱落病例的原因为使用对照药无效,患者要求改为中药治疗。
2、治疗期单项症状变化分析,两组的鼻塞、喷嚏、嗅觉减退症状、鼻粘膜肿胀的变化在统计学上无差异(P>0.05),流涕变化治疗组明显优于对照组(P<0.01),鼻痒及鼻腔分泌物变化治疗组优于对照组(P<0.05)。
3、治疗组和对照组在随访期鼻塞、流涕、喷嚏的变化,治疗组优于对照组,说明中药疗效的持续性要优于对照组。
4、研究过程中,治疗组患者用药期间及用药后1月,均未发现不良事件。
结论
1、玉蝉卫肺丸具有补益肺脾,益气固表,祛风止痒,止嚏敛涕,通利鼻窍,,抗过敏的功效。
2、玉蝉卫肺丸治疗肺脾气虚证变应性鼻炎具有很好的临床疗效及安全性。
Allergic rhinitis(AR) is a common otorhinolaryngologic disease, belongs to "Bi Qiu" category in Chinese medicine. Although the studies and treatments on nasal allergic have made great progress, but the AR has not been effectively controlled. Chinese medicine has a unique theoretical system for the AR, it emphasized the holism and differentiation treatment, and achieved satisfactory clinical curative effect. The paper is to objectively and systematically research Allergic rhinitis with lung spleen deficiency syndrome, by analyzing the patients who take Yu Chan Wei Fei pill as a treatment medicine.
Objective
To evaluate objectively the curative effect and safety of Yu Chan Wei Fei pill in treating allergic rhinitis with lung spleen deficiency syndrome.
Methods
150 patients of allergic rhinitis with lung spleen deficiency syndrome were randomly divided into treatment and control groups, by ratio 2:1. Treatment group patients were treated with Yu Chan Wei Fei pill, control group patients were treated with cetirizine hydrochloride tablet. The patients were observed their subjective symptoms and physical sign of change before and after treatment.
Results
1. Symptom comprehensive evaluation of curative effect. In FAS, the difference in level of curative effect of treatment group and control group is statistically significant. The curative effect of treatment group is better than control group (P<0.05). In PPS, the difference in level of curative effect of two groups was not statistically significant (P> 0.05). This is because that the samples of FAS were more than PPS. The reason for PPS samples'leave was the drugs ineffective of controlled groups, hence the patient asked to treat by traditional Chinese medicine.
2. Changes analysis of individual symptoms during the treatment. The changes in nasal obstruction, sneezing, hyposmia symptoms, and nasal swelling of two groups were not statistical difference (P> 0.05). The treatment group of rhinorrhea was better than control group obviously(P<0.01). The treatment group of nasal itching and nasal discharge was better than the control group (P<0.05).
3. Changes analysis of nasal obstruction, runny nose, sneezing during follow up phase. The treatment group was better than the control group, which indicated that the continued curative effect of Chinese medicine is better than the control group.
4. Adverse events were not found in treatment group, during treatment and after one month of treatment
Conclusion
1. Yu Chan Wei Fei pill can tonify the lung and the spleen, replenish Qi and secure the exterior, dispel wind and itching, stop sneezing and rhinorrhea. It has the effect of relieving the stuffy nose, and anti-allergic effect.
2. Yu Chan Wei Fei Pill has a good clinical efficacy and safety, when treating allergic rhinitis with lung spleen deficiency syndrome.
引文
1 中华耳鼻咽喉头颈外科杂志编委会鼻科组.变应性鼻炎诊治和治疗指南[J].中华耳鼻喉头颈外科杂志2009,44(12)：977.
2 Bousquet J, Khaltaev N, Cruz A, et al. Allergic Rhinitis and its Impact on Asthma(ARIA)2008 update(in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy,2008,63(Suppl 86):8-160.
3 洪娟,黄建民.嗜酸性粒细胞趋化因子与鼻变应性疾病[J].国际耳鼻咽喉头颈外科杂志.2006,30(4)：251-253.
4 曾伟.变应性鼻炎与细胞因子的关系及意义[J].甘肃中医.2005,18(8)：5-7.
5 禹华玮,徐大韬,李筱勇.变应性鼻炎患者鼻黏膜分泌物嗜酸性粒细胞观察[J].华北煤炭医学院学报.2005,7(6)：703-704.
6吴贤,郑登滋.138例变应性鼻炎患者血清特异性IgE检测结果分析[J].检验医学与临床.2009,6(21)：1838-1839.
7杨钦泰,黄雪琨,陈玉莲,等.变应性鼻炎吸入性变应原特异性IgE检测分析[J].中山大学学报.2009,30(4)：446-449.
8梁桂珍,侯穗波,单衍梅,等.变应性鼻炎主要过敏原检测的分析及研究[J].中国医药指南.2009,7(8)：195-196.
9康国志,曾莉.变态反应性鼻炎治疗研究[J].医学研究杂志.2006,35(7)：83-85.
10祝建勋.盐酸氮卓斯汀治疗变应性鼻炎的疗效观察[J].山西医药杂志.2009,38(9)：830.
11韩德民.主编.变应性鼻炎[M].北京：人民卫生出版社,2007.246.
12李素梅,牛玲,李腊梅.丙酸倍氯米松鼻气雾剂治疗变应性鼻炎126例临床观察[J].安徽医药.2009,13(9)：1111-1112.
13宋琳娜.辅舒良鼻喷剂治疗变应性鼻炎126例疗效观察[J].中国医药导报.2009,6(3)：143.
14陈欢,刘光辉.孟鲁司特治疗变应性鼻炎的疗效观察[J].华中医学杂志.2006,30(5)：404-405.
15郑立新.色甘酸钠治疗变应性鼻炎的体会[J].中国现代药物应用.2009,3(3)：70.
16 Berger WE. Monoclonal anti-IgE antibody:a novel therapy for allergic air-ways
disease[J]. Ann Allergy Asthma Immunol,2002,88(2):152-160.
17 Lin H, Boesel KM, Griffith DT, et al. Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils [J].Allergy Clin Immunol,2004,113 (2):297-302.
18 Corren J, Diaz-Sanchez D, Saxon A, et al. Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesi[J]. Ann Allergy Asthma Immunol,2004,93 (3):243-8.
19张罗,韩德民,顾之燕.变应性鼻炎的药物治疗(一)：治疗方案[J].中国耳鼻咽喉头颈外科.2006,13(1)：62-66.
20顾瑞金.用循证医学的观点看临床耳鼻喉科变态反应学的现状[J].华中医学杂志.2006,30(4)：264-265.
21王忠喜,李文静.舌下含服粉尘螨滴剂治疗变应性鼻炎临床疗效观察[J].中国医院药学杂志.2008,28(18)：1573-1575.
22康国志,曾莉.变态反应性鼻炎治疗研究[J].医学研究杂志.2006,35(7)：83-85.
23 Mauro M,Russello M,Incorvaia Qetal. Comparison of effica-cy, safety and immunologic effects of subcutaneous and sublin-gual immunotherapy in birch pollinosis:a randomized study[J]. Allerg Immunol (Paris),2007, Apr,39(4): 119-122.
24肖楚志,张海英,杨艳臣,等.低温等离子体治疗变应性鼻炎的临床应用[J].现代医药卫生.2009,25(15)：2277-2278.
25张立,鼻内镜下微波热凝治疗变应性鼻炎临床观察[J].现代医药卫生,2009,25(12)：1782-1784.
26常秀华.鼻内窥镜下等离子射频筛前神经切断术及下鼻甲减容术治疗变应性鼻炎2823例[J].中国厂矿医学.2009,22(1)：53-54.
27刘凤云,宋文欣.激光治疗变态反应性鼻炎[J].激光医学.2006,27(3)：66.
28梁维杰.鼻内镜下联合手术治疗常年性变应性鼻炎23例报告[J].中国耳鼻咽喉头颈外科杂志.2006,12(1)：71-72.
29朱玉琴.过敏性鼻炎当责之肺脾肾[J].河南中医,2000,20(6)：16.
30陈黎明,潘文有.变应性鼻炎的中医辨治探讨[J].云南中医中药杂 志,2001,22(5)：10.
31徐鸿庆.60例过敏性鼻炎的证治[J].新中医,1996,28(12)：19.
32鹿道温,王明辉.变态反应性鼻炎的中医辨证分型与变态反应学指标的相关性研究[J].中国中西医结合耳鼻咽喉科学杂志,1996,4(3)：112.
33李寿玲.干祖望老中医治疗过敏性鼻炎的经验[J].湖北中医杂志,1981,(3)：27.
34 王士贞,等.中医耳鼻咽喉科学[M].北京：中国中医药出版社,2003,124-130.
35柴向斌,王斌全.血瘀证与常年性变应性鼻炎关系初探[J].中医药研究,2002,17(4)：24-25.
36邵健民.过敏性鼻炎从瘀论治[J].山东中医杂志,1993；12(6)：48.
37李凡成.100例变态反应性鼻炎甲皱微环初步观察[J].湖南中医学院学报,1987;(3)：48.
38吴成山.过敏性鼻炎从痰饮论治[J].陕西中医,1996；17(12)：544.
39王炎,马伟民.过敏性鼻炎的辨证论治[J].现代中医药,2004(1)：35-37.
40彭镦.龙胆泻肝汤治疗过敏性鼻炎13例[J].广西中医药,1991；(6)：253.
41金慧鸣.辨证治疗变应性鼻炎86例[J].中华中医药杂志,2005,20(10)：615-616.
42李寿岭.干祖望治疗过敏性鼻炎的经验[J].湖北中医杂志,1981,3(6)：27.
43李健民.中医辨证治疗变应性鼻炎36例[J].河南中医学院学报,2009,24(4)：88-89.
44石钟坤.中药治疗过敏性鼻炎临床观察[J].辽宁中医杂志,2006,33(5)：568.
45王广科,柴峰,蔡纪堂.鼻鼽汤治疗变应性鼻炎的临床观察[J].四川中医,2005,23(5)：80-81.
46郝建莹,郝雪莹,关洁,等.补肺益脾温肾法治疗变应性鼻炎60例[J].中医杂志,2006,47(6)：423.
47李高照.苍耳桂枝汤治疗鼻鼽84例[J].甘肃中医,2009,22(2)：43.
48洪伟.复方鼻炎汤治疗变应性鼻炎的临床研究[J].使用中西医结合临床,2005,5(5)：41.
49黄平,黄永久,马兆鑫,等.截敏祛风汤治疗变态反应性鼻炎的临床观察[J].上海中医药杂志,2006,40(2)：35.
50王晓平.温阳通窍汤治疗过敏性鼻炎的临床观察[J].中医耳鼻喉科学研究,2007,6(04)：25.
51刘怀文.针刺治疗过敏性鼻炎的疗效观察[J].中医中药,2006,3(20)：99.
52谯凤英,赵铭辉,沈金城,赵海双,朱慧娴,王洪坤,赵红.针刺治疗过敏性鼻炎的临床观察[J].天津中医药,2005,22(6)：482.
53朱秀兰,刘君奇.针灸治疗过敏性鼻炎56例[J].甘肃中医,2009,22(1)：52.
54杨桂宋,郝首超,张爱华,等.艾灸为主治疗过敏性鼻炎[J].中国针灸,1995,15(4)：55.
55吴晖,庄金敏,李华,等.抗敏灵穴位贴敷治疗变应性鼻炎[J].中华中西医杂志,2003,4(5)：737.
56姚贷君.辣椒膏外敷治疗过敏性鼻炎25例[J.]辽宁中医杂志,1998,2(4)：159.
57赵超.中药敷脐治疗过敏性鼻炎30例[J].中国中西医结合杂志,1992,12(3)：173.
58吴震西.发泡膏穴位贴敷治疗过敏性鼻炎64例[J].中医杂志,1988,(9)：44.
59黄卓燕,张勉,韦子章,等.鼻敏水治疗变应性鼻炎大鼠的实验研究[J].时珍国医国药.2007,18(1)：100-102.
60王大海,退敏滴鼻液治疗过敏性鼻炎的近期疗效观察[J].湖南中医学院学报,2000,20(1)：43.
61高志银.鼻炎药枕治疗过敏性鼻炎[J].浙江中医杂志,1992,27(10)：453.
62张志泽,王卫红.耳穴贴压法治疗过敏性鼻炎300例[J].实用中医药杂志,2004,20(7):379.
63齐伟,王朝辉,耳穴贴压治疗过敏性鼻炎50例临床观察[J].长春中医药大学学报,2008,24(6)：721.
64梁吉,刘弘.耳穴埋针治疗过敏性鼻炎40例分析[J].甘肃中医,1999,12(4)：46-47.
65朱向阳,邓耀成.耳穴药物注射治疗过敏性鼻炎[J].针灸临床杂志,2000,16(6)：46-47.
66温峰云,宋永强,李丽霞,王国明.穴位注射治疗过敏性葬炎86例临床观察[J].中医中药,2006,14(18)：130.
67雷晓兰,朱皓华,柳冰.穴位注射治疗过敏性鼻炎的IgE观察[J].实用中西医 结合临床,2009,9(4)：46-47.
68郑国权,李娜萍,王书华.迎香穴封闭治疗变应性鼻炎[J].中西医结合杂志,1991,11(6)：345.
69孙燕,曹铁民.针刺加穴位注射治疗过敏性鼻炎46例[J].针灸临床杂志,2000,16(3)：2-4.
70覃继锋.穴位埋线法治疗过敏性鼻炎197例[J].JCAM,2006,22 (8):36
71陈永红.穴位刺血治疗变应性鼻炎的临床和实验观察[J].中医外治杂志,1997,6(5)：7-8.
72毕世梅,王瑛,刘月秋.过敏性鼻炎超声穴位治疗43例疗效观察[J].黑龙江中医药,1997(2)：46.
73日下史章等.新的经络磁疗法治疗变应性鼻炎[J].日本良导络自律神经学会杂志,1991,36(4)：3-4.
74涂鑫,毛海峰,汤玉君.复方辛荑注射液下鼻甲注射治疗过敏性鼻炎[J].中西医结合杂志,1984,4(3)：185.
75张天宇,曹茂良,王后国.低温等离子加中药治疗变应性鼻炎的临床观察[J].实用中西医结合临床,2009,9(4)：66-67.
76王兴鸣.微波热凝结合中药治疗过敏性鼻炎100例[J].陕西中医,2005,26(3)：234.
77陈晓征,蔡恒.中西医结合治疗常年性变应性鼻炎疗效观察[J].中原医刊2006,33(5)：60-61.
1 Bousquet J, Khaltaev N, Cruz A, et al. Allergic Rhinitis and its Impact on Asthma(ARIA)2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy,2008,63(Suppl 86):8-160.
2韩德民,张罗,黄丹.我国11个城市变应性鼻炎自报患病率调查[J].中华耳鼻咽喉头颈外科杂志.2007,42：378-384.
3张颖,张蓉,朱海静.中药治疗变应性鼻炎用药特点及分析[J].中国中医药信息杂志.2009,16(5)：97-98.
2 Bousquet J, Khaltaev N, Cruz A, et al. Allergic Rhinitis and its Impact on Asthma(ARIA)2008 update(in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy,2008,63(Suppl 86):8-160.
3 洪娟,黄建民.嗜酸性粒细胞趋化因子与鼻变应性疾病[J].国际耳鼻咽喉头颈外科杂志.2006,30(4)：251-253.
4 曾伟.变应性鼻炎与细胞因子的关系及意义[J].甘肃中医.2005,18(8)：5-7.
5 禹华玮,徐大韬,李筱勇.变应性鼻炎患者鼻黏膜分泌物嗜酸性粒细胞观察[J].华北煤炭医学院学报.2005,7(6)：703-704.
6吴贤,郑登滋.138例变应性鼻炎患者血清特异性IgE检测结果分析[J].检验医学与临床.2009,6(21)：1838-1839.
7杨钦泰,黄雪琨,陈玉莲,等.变应性鼻炎吸入性变应原特异性IgE检测分析[J].中山大学学报.2009,30(4)：446-449.
8梁桂珍,侯穗波,单衍梅,等.变应性鼻炎主要过敏原检测的分析及研究[J].中国医药指南.2009,7(8)：195-196.
9康国志,曾莉.变态反应性鼻炎治疗研究[J].医学研究杂志.2006,35(7)：83-85.
10祝建勋.盐酸氮卓斯汀治疗变应性鼻炎的疗效观察[J].山西医药杂志.2009,38(9)：830.
11韩德民.主编.变应性鼻炎[M].北京：人民卫生出版社,2007.246.
12李素梅,牛玲,李腊梅.丙酸倍氯米松鼻气雾剂治疗变应性鼻炎126例临床观察[J].安徽医药.2009,13(9)：1111-1112.
13宋琳娜.辅舒良鼻喷剂治疗变应性鼻炎126例疗效观察[J].中国医药导报.2009,6(3)：143.
14陈欢,刘光辉.孟鲁司特治疗变应性鼻炎的疗效观察[J].华中医学杂志.2006,30(5)：404-405.
15郑立新.色甘酸钠治疗变应性鼻炎的体会[J].中国现代药物应用.2009,3(3)：70.
16 Berger WE. Monoclonal anti-IgE antibody:a novel therapy for allergic air-ways
disease[J]. Ann Allergy Asthma Immunol,2002,88(2):152-160.
17 Lin H, Boesel KM, Griffith DT, et al. Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils [J].Allergy Clin Immunol,2004,113 (2):297-302.
18 Corren J, Diaz-Sanchez D, Saxon A, et al. Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesi[J]. Ann Allergy Asthma Immunol,2004,93 (3):243-8.
19张罗,韩德民,顾之燕.变应性鼻炎的药物治疗(一)：治疗方案[J].中国耳鼻咽喉头颈外科.2006,13(1)：62-66.
20顾瑞金.用循证医学的观点看临床耳鼻喉科变态反应学的现状[J].华中医学杂志.2006,30(4)：264-265.
21王忠喜,李文静.舌下含服粉尘螨滴剂治疗变应性鼻炎临床疗效观察[J].中国医院药学杂志.2008,28(18)：1573-1575.
22康国志,曾莉.变态反应性鼻炎治疗研究[J].医学研究杂志.2006,35(7)：83-85.
23 Mauro M,Russello M,Incorvaia Qetal. Comparison of effica-cy, safety and immunologic effects of subcutaneous and sublin-gual immunotherapy in birch pollinosis:a randomized study[J]. Allerg Immunol (Paris),2007, Apr,39(4): 119-122.
24肖楚志,张海英,杨艳臣,等.低温等离子体治疗变应性鼻炎的临床应用[J].现代医药卫生.2009,25(15)：2277-2278.
25张立,鼻内镜下微波热凝治疗变应性鼻炎临床观察[J].现代医药卫生,2009,25(12)：1782-1784.
26常秀华.鼻内窥镜下等离子射频筛前神经切断术及下鼻甲减容术治疗变应性鼻炎2823例[J].中国厂矿医学.2009,22(1)：53-54.
27刘凤云,宋文欣.激光治疗变态反应性鼻炎[J].激光医学.2006,27(3)：66.
28梁维杰.鼻内镜下联合手术治疗常年性变应性鼻炎23例报告[J].中国耳鼻咽喉头颈外科杂志.2006,12(1)：71-72.
29朱玉琴.过敏性鼻炎当责之肺脾肾[J].河南中医,2000,20(6)：16.
30陈黎明,潘文有.变应性鼻炎的中医辨治探讨[J].云南中医中药杂 志,2001,22(5)：10.
31徐鸿庆.60例过敏性鼻炎的证治[J].新中医,1996,28(12)：19.
32鹿道温,王明辉.变态反应性鼻炎的中医辨证分型与变态反应学指标的相关性研究[J].中国中西医结合耳鼻咽喉科学杂志,1996,4(3)：112.
33李寿玲.干祖望老中医治疗过敏性鼻炎的经验[J].湖北中医杂志,1981,(3)：27.
34 王士贞,等.中医耳鼻咽喉科学[M].北京：中国中医药出版社,2003,124-130.
35柴向斌,王斌全.血瘀证与常年性变应性鼻炎关系初探[J].中医药研究,2002,17(4)：24-25.
36邵健民.过敏性鼻炎从瘀论治[J].山东中医杂志,1993；12(6)：48.
37李凡成.100例变态反应性鼻炎甲皱微环初步观察[J].湖南中医学院学报,1987;(3)：48.
38吴成山.过敏性鼻炎从痰饮论治[J].陕西中医,1996；17(12)：544.
39王炎,马伟民.过敏性鼻炎的辨证论治[J].现代中医药,2004(1)：35-37.
40彭镦.龙胆泻肝汤治疗过敏性鼻炎13例[J].广西中医药,1991；(6)：253.
41金慧鸣.辨证治疗变应性鼻炎86例[J].中华中医药杂志,2005,20(10)：615-616.
42李寿岭.干祖望治疗过敏性鼻炎的经验[J].湖北中医杂志,1981,3(6)：27.
43李健民.中医辨证治疗变应性鼻炎36例[J].河南中医学院学报,2009,24(4)：88-89.
44石钟坤.中药治疗过敏性鼻炎临床观察[J].辽宁中医杂志,2006,33(5)：568.
45王广科,柴峰,蔡纪堂.鼻鼽汤治疗变应性鼻炎的临床观察[J].四川中医,2005,23(5)：80-81.
46郝建莹,郝雪莹,关洁,等.补肺益脾温肾法治疗变应性鼻炎60例[J].中医杂志,2006,47(6)：423.
47李高照.苍耳桂枝汤治疗鼻鼽84例[J].甘肃中医,2009,22(2)：43.
48洪伟.复方鼻炎汤治疗变应性鼻炎的临床研究[J].使用中西医结合临床,2005,5(5)：41.
49黄平,黄永久,马兆鑫,等.截敏祛风汤治疗变态反应性鼻炎的临床观察[J].上海中医药杂志,2006,40(2)：35.
50王晓平.温阳通窍汤治疗过敏性鼻炎的临床观察[J].中医耳鼻喉科学研究,2007,6(04)：25.
51刘怀文.针刺治疗过敏性鼻炎的疗效观察[J].中医中药,2006,3(20)：99.
52谯凤英,赵铭辉,沈金城,赵海双,朱慧娴,王洪坤,赵红.针刺治疗过敏性鼻炎的临床观察[J].天津中医药,2005,22(6)：482.
53朱秀兰,刘君奇.针灸治疗过敏性鼻炎56例[J].甘肃中医,2009,22(1)：52.
54杨桂宋,郝首超,张爱华,等.艾灸为主治疗过敏性鼻炎[J].中国针灸,1995,15(4)：55.
55吴晖,庄金敏,李华,等.抗敏灵穴位贴敷治疗变应性鼻炎[J].中华中西医杂志,2003,4(5)：737.
56姚贷君.辣椒膏外敷治疗过敏性鼻炎25例[J.]辽宁中医杂志,1998,2(4)：159.
57赵超.中药敷脐治疗过敏性鼻炎30例[J].中国中西医结合杂志,1992,12(3)：173.
58吴震西.发泡膏穴位贴敷治疗过敏性鼻炎64例[J].中医杂志,1988,(9)：44.
59黄卓燕,张勉,韦子章,等.鼻敏水治疗变应性鼻炎大鼠的实验研究[J].时珍国医国药.2007,18(1)：100-102.
60王大海,退敏滴鼻液治疗过敏性鼻炎的近期疗效观察[J].湖南中医学院学报,2000,20(1)：43.
61高志银.鼻炎药枕治疗过敏性鼻炎[J].浙江中医杂志,1992,27(10)：453.
62张志泽,王卫红.耳穴贴压法治疗过敏性鼻炎300例[J].实用中医药杂志,2004,20(7):379.
63齐伟,王朝辉,耳穴贴压治疗过敏性鼻炎50例临床观察[J].长春中医药大学学报,2008,24(6)：721.
64梁吉,刘弘.耳穴埋针治疗过敏性鼻炎40例分析[J].甘肃中医,1999,12(4)：46-47.
65朱向阳,邓耀成.耳穴药物注射治疗过敏性鼻炎[J].针灸临床杂志,2000,16(6)：46-47.
66温峰云,宋永强,李丽霞,王国明.穴位注射治疗过敏性葬炎86例临床观察[J].中医中药,2006,14(18)：130.
67雷晓兰,朱皓华,柳冰.穴位注射治疗过敏性鼻炎的IgE观察[J].实用中西医 结合临床,2009,9(4)：46-47.
68郑国权,李娜萍,王书华.迎香穴封闭治疗变应性鼻炎[J].中西医结合杂志,1991,11(6)：345.
69孙燕,曹铁民.针刺加穴位注射治疗过敏性鼻炎46例[J].针灸临床杂志,2000,16(3)：2-4.
70覃继锋.穴位埋线法治疗过敏性鼻炎197例[J].JCAM,2006,22 (8):36
71陈永红.穴位刺血治疗变应性鼻炎的临床和实验观察[J].中医外治杂志,1997,6(5)：7-8.
72毕世梅,王瑛,刘月秋.过敏性鼻炎超声穴位治疗43例疗效观察[J].黑龙江中医药,1997(2)：46.
73日下史章等.新的经络磁疗法治疗变应性鼻炎[J].日本良导络自律神经学会杂志,1991,36(4)：3-4.
74涂鑫,毛海峰,汤玉君.复方辛荑注射液下鼻甲注射治疗过敏性鼻炎[J].中西医结合杂志,1984,4(3)：185.
75张天宇,曹茂良,王后国.低温等离子加中药治疗变应性鼻炎的临床观察[J].实用中西医结合临床,2009,9(4)：66-67.
76王兴鸣.微波热凝结合中药治疗过敏性鼻炎100例[J].陕西中医,2005,26(3)：234.
77陈晓征,蔡恒.中西医结合治疗常年性变应性鼻炎疗效观察[J].中原医刊2006,33(5)：60-61.
1 Bousquet J, Khaltaev N, Cruz A, et al. Allergic Rhinitis and its Impact on Asthma(ARIA)2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy,2008,63(Suppl 86):8-160.
2韩德民,张罗,黄丹.我国11个城市变应性鼻炎自报患病率调查[J].中华耳鼻咽喉头颈外科杂志.2007,42：378-384.
3张颖,张蓉,朱海静.中药治疗变应性鼻炎用药特点及分析[J].中国中医药信息杂志.2009,16(5)：97-98.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |