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延边地区不同民族高血压及其影响因素分布特征的比较研究
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摘要
目的:比较分析延边地区不同民族人群高血压及其影响因素分布特征,以及它们之间的相关性。
     方法:①于2005年8月至2006年8月在延边朝鲜族自治州安图县内采用简单随机抽取的方法抽取30岁以上的朝鲜族和汉族常住居民3158名进行调查。选择研究对象时,排除患有严重的器质性疾病的人群,而且被纳入的研究对象均对调查内容知情同意。②在被选社区及其卫生院,采用家访的方法和健康体检的形式收集本次调查的相关信息。③调查前对所有调查人员严格培训,规范调查内容、操作流程和方法,并按统一的调查表(内容包括研究对象的一般情况、吸烟、饮酒、心血管疾病的既往史及家族史等)进行家访询问调查。④测量身高、体重、腰围、血压等。⑤取清晨空腹(禁食12h)静脉血,测量血清总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、血糖等指标。血脂及血糖指标均用全自动生化分析仪测定。⑥计量资料行ANOVA检验,计数资料的比较采用x~2和u检验。高血压及其亚型影响因素的分析采用多因素回归分析,分别以高血压及其亚型为因变量,以性别、民族、年龄、整体型肥胖、腹型肥胖、高胆固醇血症、高甘油三酯血症、混合型高脂血症、高血糖、吸烟、饮酒为自变量进行Logistic回归分析,BACKWARD法选择变量,以a=0.05为入选变量的显著性水准,α=0.10为删除变量的显著性水准。
     结果:进入本次结果分析的总例数为3158名,其中朝鲜族1358名(男性566名、女性792名),占43.0%;汉族1800名(男性654名、女性1146名)占57.0%。①朝鲜族和汉族女性收缩压(SBP)均值分别为130.3 mmHg、124.7 mmHg,朝鲜族和汉族男性舒张压(DBP)均值分别为88.2 mmHg、86.0 mmHg,朝鲜族和汉族女性DBP均值分别为85.1 mmHg,81.7 mmHg,差异均有统计学意义(P<0.05)。②高血压粗患病率朝、汉男性分别为52.3%和41.0%,其年龄调整标准化患病率分别为44.9%和39.4%,无论粗患病率还是标化患病率朝鲜族男性均明显高于汉族(P<0.01)。朝、汉族女性高血压粗患病分别为40.9%和29.7%,其年龄调整标化患病率分别为31.6%和28.6%,无论粗患病率还是标化患病率朝鲜族女性均明显高于汉族(P<0.01)。朝、汉族男女高血压患病率均随年龄的增高而升高,其升高趋势有统计学意义(P<0.01)。③朝鲜族男性人群中,单纯收缩期高血压(Isolated systolic hypertension,ISH)、单纯舒张期高血压(Isolated diastolic hypertension,IDH)及收缩期高血压合并舒张期高血压(Systoliccombined diastolic hypertension,SDH)年龄调整患病率分别为4.3%,16.8%,23.8%,汉族男性分别为4.1%,16.8%,18.5%,其中ISH(P<0.05)和SDH(P<0.01)患病率朝鲜族高于汉族;在女性人群中,朝鲜族分别为4.3%,16.8%,23.8%,汉族分别为6.0%,8.0%,14.6%,其中IDH和SDH患病率朝鲜族高于汉族(P<0.01),而ISH则汉族高于朝鲜族(p<0.01)。朝、汉族男女的ISH和SDH的患病率均随年龄增长而升高,其升高趋势有统计学意义(P<0.01),而朝、汉族性的IDH患病率则随年龄增长而降低,其降低趋势有统计学意义(P<0.05)。④朝鲜族高血压人群中,ISH、IDH、SDH所占比例分别为12.1%,31.0%,56.9%,汉族分别为14.3%,33.7%,52.0%。不同特征人群均以SDH型高血压为最多见,且高血压不同亚型的民族分布有所不同。高血压人群中,ISH、IDH和SDH在不同年龄高血压患者中所占的比例也存在很大差别。30岁年龄组高血压患者中IDH所占的比例朝、汉族分别为53.3%和57.8%,而ISH分别为6.7%和8.4%,SDH分别为40.0%和33.7%;40~50岁年龄组高血压患者中IDH所占的比例朝、汉族分别为36.5%和34.8%,而ISH分别为8.2%和10.9%,SDH分别为55.3%和54.3%;≥60岁年龄组高血压患者中IDH分别为16.9%和13.3%,而ISH占的比例朝、鲜汉族分别为20.4%和30.0%,SDH分别为62.7%和56.7%。在高血压人群中,随着年龄的增长,ISH,SDH的比例显著增高,而IDH的比例显著降低。⑤3种亚型高血压组与正常血压(NBP)组间:a)朝鲜族人群ISH组的Age,TG,SBP,DBP较NBP组显著升高(P<0.01),汉族人群ISH组的Age,WHtR(P<0.05),SBP,DBP较NBP组显著升高(P<0.01);b)朝、汉族人群IDH组的BMI,WHtR,TC,TG,SBP,DBP较NBP组显著升高(P<0.05);c)朝、汉族人群SDH组的Age,BMI,WHtR,TC(P<0.05),TG,SBP,DBP较NBP组显著升高(P<0.01)。⑥多因素分析结果表明:a)高血压与民族、性别、年龄、整体型肥胖、腹型肥胖、高胆固醇血症、高甘油三酯血症、混合型高脂血症、吸烟显著相关;b)单纯收缩期高血压与民族、年龄、腹型肥胖、高血糖显著相关;c)单纯舒张期高血压与民族、性别、年龄、腹型肥胖显著相关;d)收缩期高血压合并舒张期高血压与民族、性别、年龄、整体型肥胖、腹型肥胖、高胆固醇血症、高甘油三酯血症、混合型高脂血症、吸烟显著相关。
     结论:1)本地区一般人群的高血压及其亚型的患病水平较高,其患病水平存在明显的民族差异。朝、汉族男女高血压患病率均随年龄的增高而升高。2)在高血压人群中,不同特征人群均以SDH为最多见,而且高血压不同亚型的民族分布有所不同,随着年龄的增长ISH和SDH的比例显著增高和IDH的比例显著降低。3)3种亚型高血压组与正常血压(NBP)组间:a)朝鲜族人群ISH组的Age,TG,SBP,DBP较NBP组显著升高,汉族人群ISH组的Age,WHtR,SBP,DBP较NBP组显著升高;b)朝、汉族人群IDH组的BMI,WHtR,TC,TG,SBP,DBP较NBP组显著升高;c)朝、汉族人群SDH组的Age,BMI,WHtR,TC,TG,SBP,DBP较NBP组显著升高。4)本地区高血压与民族、性别、年龄、整体型肥胖、腹型肥胖、高胆固醇血症、高甘油三酯血症、混合型高脂血症、吸烟显著相关,且其在不同亚型高血压间的分布特点有所不同。
Objective:To compare the distribution of hypertension and its influencing factors,and the relationship between hypertension and its influencing factors in Korean and Han nationality of Yanbian Korean Autonomous Prefecture area.
     Methods:①Using a simple random sampling method,3,158 permanent residents aged more than 30 years and selected in the Antu County of Yanbian were carried out an investigation from August 2005 to August 2006.All of subjects was selected after eliminating the cases suffered from serious organic diseases and knew the informed consent.②Using the home visit and health examination,the relevant information for this study were collected in the selected communities and health centers.③The investigators were trained, and it was standardized that the survey contents,operational procedures and methods,and the home visit and inquiries were performed in accordance with unified questionnaire (including the general information,smoking,drinking,past history and family history of cardiovascular diseases,etc.).④It was measured that the height,weight,waist circumference and blood pressure,etc.⑤The fasting vein blood(fasting for 12 h) was taken in early morning,and it was measured that the serum total cholesterol(TC),triglyceride (TG),high-density lipoprotein cholesterol(HDL-C),blood glucose.The blood lipids and blood glucose were measured by automatic biochemical analyzer.⑥The measurement data were examined by ANOVA test;the numeration data were compared with the Chi square and u test;the hypertension and its subtypes influencing factors were analyzed by the multi-regression analysis;hypertension and its subtypes as the dependent variable and nationality,age,sex,hyperglycemia,high total cholesterol,high triglyceride,high TC and TG,overall obesity and abdominal obesity as independent variable were analyzed by the Logistic regression analysis;the variables were selected by BACKWARD,selected variables were significant level asα=0.05 and deleted variables were significant level asα=0.10.
     Results:Out of 3,158 cases,1,358 cases(43.0%) were Korean nationality(566 of male and 792 of female),and 1,800 cases(57.0%) were Han nationality(654 of male and 1,146 of female).①For female,the average level(mmHg) of systolic blood pressure(SBP) 130.3 in Korean nationality,and that was 124.7 in Han nationality,and there was significant ethnic difference(P<0.05);the average level(mmHg) of diastolic blood pressure(DBP) was 88.2 in Korean men and 86.0 in Han men,and 85.1 in Korean women and 81.7 in Han women, respectively,and there were significant ethnic differences(P<0.05).②In this study population,the crude rate of hypertension was 52.3%in Korean men,41.0%in Han men, 40.9%in Korean women and 29.7%in Han women,respectively;the age-adjusted prevalence of hypertension was 44.9%in Korean men,39.4%in Han men,31.6%in Korean women and 28.6%in Han women,respectively.The crude and the age-adjusted prevalence of hypertension in Korean nationality were significantly higher than those in Han nationality in both sexes(P<0.01).The prevalence of hypertension increased along with the increase of age(P<0.01).③The age-adjusted prevalence of isolated systolic hypertension(ISH), isolated diastolic hypertension(IDH) and systolic combined diastolic hypertension(SDH) was 4.3%,16.8%and 23.8%in Korean men and that was 4.1%,16.8%and 18.5%in Han men,respectively,and there were significant ethnic differences in ISH(P<0.05) and SDH (P<0.01).For female,the age-adjusted prevalence of ISH,IDH and SDH was 4.3%,16.8% and 23.8%in Korean and that was 6.0%,8.0%and 14.6%in Han,respectively,and there were significant ethnic differences(P<0.01) in all subtypes of hypertension.The prevalence of ISH and SDH was progressively higher and the IDH progressively lower with the increases of age.④The proportion of ISH,IDH and SDH were12.1%,31.0%and 56.9% among Korean hypertensive population,and that were 14.3%,33.7%and 52.0%among Han hypertensive population,and SDH was more frequent in this area.The ages in proportion of IDH,ISH and SDH were significant differences.Among Korean hypertensive population of age<30 years,the proportion of IDH,ISH and SDH were 53.3%,6.7%and 40.0%, respectively,and that of Han were 57.8%,8.4%and 33.7%,respectively,and among Korean hypertensive population of 40~50 years,that were 36.5%,8.2%and 55.3%,respectively,and that of Han were 34.8%,10.9%and 54.3%.In contrast,among Korean patients of age≥60 years,the proportion of IDH,ISH and SDH were 16.9%,20.4%and 62.7,respectively,and that of Han were 13.3%,30.0%and 56.7%,respectively.Among hypertensive population, the proportion of ISH and SDH were progressively higher and that of IDH progressively lower with the increases of age.⑤In comparison with normal blood pressure(NBP) subgroup,age,TG,SBP and DBP was significantly increased in ISH among Korean population(P<0.01),and age,WHtR(P<0.05),SBP and DBP were significantly increased in ISH among Han population(P<0.01);BMI,WHtR,TC,TG,SBP and DBP were significantly increased in IDH among combined population of Korean and Han(P<0.05); age,BMI,WHtR,TC(P<0.05),TG,SBP and DBP were significantly increased in SDH among combined population of Korean and Han(P<0.01).⑥The results of multifactor analysis showed that hypertension is closely related with nationality(Korean),sex,age, overall obesity,abdominal obesity,high TC,high TG,high TC combined high TG and smoking;ISH is closely related with nationality(Korean),age,abdominal obesity and hyperglycemia;IDH is closely related with nationality(Korean),sex,age and abdominal obesity;SDH is closely related with nationality(Korean),sex,age,overall obesity, abdominal obesity,high TC,high TG,high TC combined high TG and smoking.
     Conclusion:①The prevalence of hypertension and its subtypes in the general population is relatively high in Yanbian area and the distribution of that between Korean nationality and Han nationality were significant difference,and the prevalence of hypertension increased along with the increase of age(P<0.01);②The proportion of ISH,IDH and SDH among hypertensive population had significant ethnic differences.ISH and SDH were progressively higher and the IDH progressively lower with the increases of age,and the SDH was more frequent in this area;③In comparison with normal blood pressure(NBP) subgroup,age,TG, SBP and DBP was significantly increased in ISH among Korean population,and age,WHtR, SBP and DBP were significantly increased in ISH among Han population;BMI,WHtR,TC, TG,SBP and DBP were significantly increased in IDH among combined population of Korean and Han;age,BMI,WHtR,TC,TG,SBP and DBP were significantly increased in SDH among combined population of Korean and Han(P<0.01).④Hypertension is closely related with nationality(Korean),sex,age,overall obesity,abdominal obesity,high TC,high TG,high TC combined high TG and smoking,and the distribution of these influencing factors in subtypes of hypertension were significant difference.
引文
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