大麻素对大鼠三叉神经节神经元上TRPV1受体的调制及其机制探讨
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摘要
尽管大麻素对TRPV1受体的抑制作用可以解释大麻素在外周的抗痛觉过敏和抗伤害感受效应,但大麻素抑制初级感觉神经元上TRPV1受体的机制目前还不清楚。因此,我们使用内源性大麻素anandamide (AEA)和人工合成的大麻素WIN55,212-2 (WIN)研究大麻素如何对三叉神经节神经元上TRPV1受体进行调制。首先,我们研究AEA和WIN对Icap调制的浓度依赖性：此量效曲线呈“钟”形,并且AEA和WIN对Icap调制的浓度阈值非常低(低于10-15 M)。AEA和WIN对Icap的最大抑制浓度分别为10-10M和10-9M,此时,AEA和WIN对Icap的最大抑制率分别为89±7.5%和95±1.6%。当AEA和WIN的浓度高于10-SM,AEA和WIN对Icap的抑制作用被完全翻转。本实验中,我们检测了一些细胞内信号转导通路来探究AEA和WIN对Icap的抑制作用的胞内信号转导机制。我们发现,WIN对Icap的抑制作用可以被PKA系统特异性拮抗剂H-89和KT5720完全翻转。同样,WIN对Icap的抑制作用也可被PKC系统特异性拮抗剂BIM和staurosporine完全翻转。我们也发现PKG系统拮抗剂PKGi可部分翻转WIN对Icap的抑制作用,而G蛋白系统拮抗剂GDP-βs和PLC拮抗剂U73122则不影响WIN对Icap的抑制作用。实验表明细胞内一些信号转导通路,如PKA和PKC,参与了大麻素对Icap的抑制作用。
本实验应用全细胞膜片钳技术,在大鼠三叉神经节神经元上探讨渗透压对5-HT3受体的调制作用。结果显示：(1)实验中大部分受检细胞(75%)对胞外给予5—HT(3-300μM)敏感,可记录到具有浓度依赖性的内向电流,该电流可被5—HT3受体特异性拮抗剂ICS 205-930(1μM)阻断。(2)实验中反复给予100μM 5-HT,间隔3分钟,发现5-HT3受体激活电流无衰减现象。(3)实验中预加低渗细胞外液(260mOsm),对5-HT3受体激活电流无影响。(4)预加高渗细胞外液(348mOsm),对5-HT3受体激活电流无影响。以上结果表明,渗透压对大鼠三叉神经节神经元上5-HT3受体没有调制作用。
Although the inhibitory effect of cannabinoids on TRPV1 channel may explain the efficacy of peripheral cannabinoids in antihyperalgesia and antinociceptive actions, the mechanism for cannabinoid-induced inhibition of TRPV1 in primary sensory neurons is not understood. Therefore, we explored how anandamide (AEA, an endogenous cannabinoid) and WIN55,212-2 (WIN, a synthetic cannabinoid) inhibited TRPV1 in rat trigeminal ganglion neurons. The concentration dependence of the effect of AEA and WIN on Icap was studied:a "bell" shaped concentration dependent curve was obtained with very low threshold (less than 10-15 M for both AEA and WIN). The maximal inhibitions were at concentration 10-10M and 10-9M, and at these concentrations the Icap was reduced by 89±7.5% and 95±1.6% respectively. When the concentration of AEA or WIN was higher than 10-5M, inhibitory effects were completely reversed. In this study several intracellular signaling transduction pathways were tested to study whether they were involved in the inhibitory effects of AEA or WIN on capsaicin-induced current (Icap).It was newly found that the inhibitory effect of WIN on Icap was completely reversed by PKA antagonists H-89 and KT5720 as well as by PKC antagonists BIM and staurosporine. It was also found that the inhibitory effect was partly reversed by PKG antagonist PKGi, while G-protein antagonist GDP-βs and PLC antagonist U73122 had no effect on the inhibitory effect. It suggests that several intracellular signaling transduction pathways underlie the inhibitory effects of cannabinoids on Icap,including PKA and PKC systems.
This experiment aimed to investigate the modulation of osmolality on 5-HT-activated currents(I5-HT) in primary sensory neurons. Whole cell-patch clamp recording was performed on cultured SD rat trigeminal ganglion (TG) neurons. (1) The majority of examined neurons (75%) were sensitive to 5-HT (3-300μM).5-HT3 receptor activated inward currents in a concentration-dependent manner, and I5-HT3 were blocked by ICS 205-930 (1μM), a selective antagonist of the 5-HT3 receptor. (2) 100μM 5-HT was repeated exerted for every three minut, and 5-HT3 receptor activated inward currents had no change. (3) When 260mOsm was preapplied extracellularly,5-HT3 receptor activated inward currents had no change. (4) When 348mOsm was preapplied extracellularly,5-HT3 receptor activated inward currents also had no change. It suggests that osmolality has no modulation on 5-HT3 receptor activated current.
本实验应用全细胞膜片钳技术,在大鼠三叉神经节神经元上探讨渗透压对5-HT3受体的调制作用。结果显示：(1)实验中大部分受检细胞(75%)对胞外给予5—HT(3-300μM)敏感,可记录到具有浓度依赖性的内向电流,该电流可被5—HT3受体特异性拮抗剂ICS 205-930(1μM)阻断。(2)实验中反复给予100μM 5-HT,间隔3分钟,发现5-HT3受体激活电流无衰减现象。(3)实验中预加低渗细胞外液(260mOsm),对5-HT3受体激活电流无影响。(4)预加高渗细胞外液(348mOsm),对5-HT3受体激活电流无影响。以上结果表明,渗透压对大鼠三叉神经节神经元上5-HT3受体没有调制作用。
Although the inhibitory effect of cannabinoids on TRPV1 channel may explain the efficacy of peripheral cannabinoids in antihyperalgesia and antinociceptive actions, the mechanism for cannabinoid-induced inhibition of TRPV1 in primary sensory neurons is not understood. Therefore, we explored how anandamide (AEA, an endogenous cannabinoid) and WIN55,212-2 (WIN, a synthetic cannabinoid) inhibited TRPV1 in rat trigeminal ganglion neurons. The concentration dependence of the effect of AEA and WIN on Icap was studied:a "bell" shaped concentration dependent curve was obtained with very low threshold (less than 10-15 M for both AEA and WIN). The maximal inhibitions were at concentration 10-10M and 10-9M, and at these concentrations the Icap was reduced by 89±7.5% and 95±1.6% respectively. When the concentration of AEA or WIN was higher than 10-5M, inhibitory effects were completely reversed. In this study several intracellular signaling transduction pathways were tested to study whether they were involved in the inhibitory effects of AEA or WIN on capsaicin-induced current (Icap).It was newly found that the inhibitory effect of WIN on Icap was completely reversed by PKA antagonists H-89 and KT5720 as well as by PKC antagonists BIM and staurosporine. It was also found that the inhibitory effect was partly reversed by PKG antagonist PKGi, while G-protein antagonist GDP-βs and PLC antagonist U73122 had no effect on the inhibitory effect. It suggests that several intracellular signaling transduction pathways underlie the inhibitory effects of cannabinoids on Icap,including PKA and PKC systems.
This experiment aimed to investigate the modulation of osmolality on 5-HT-activated currents(I5-HT) in primary sensory neurons. Whole cell-patch clamp recording was performed on cultured SD rat trigeminal ganglion (TG) neurons. (1) The majority of examined neurons (75%) were sensitive to 5-HT (3-300μM).5-HT3 receptor activated inward currents in a concentration-dependent manner, and I5-HT3 were blocked by ICS 205-930 (1μM), a selective antagonist of the 5-HT3 receptor. (2) 100μM 5-HT was repeated exerted for every three minut, and 5-HT3 receptor activated inward currents had no change. (3) When 260mOsm was preapplied extracellularly,5-HT3 receptor activated inward currents had no change. (4) When 348mOsm was preapplied extracellularly,5-HT3 receptor activated inward currents also had no change. It suggests that osmolality has no modulation on 5-HT3 receptor activated current.
引文
1.AHLUWALIA, J., URBAN, L., BEVAN, S., CAPOGNA, M.& NAGY, I. (2002). Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neurones. Neuroscience,110, 747-753.
2.Ahluwalia J, Urban L, Capogna M, Bevan S, Nagy I. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience 100:685-688,2000.
3.Amol M. Patwardhan, Nathaniel A. Jeske, Theodore J. Price, Nikita Gamper, Armen N. Akopian, and Kenneth M. Hargreaves (2006). The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. PNAS 103 (30):11393-11398
4.Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, et al. (2007) Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci10:870-879.
5.Armen N. Akopian, Nikita B. Ruparel, Amol Patwardhan, Kenneth M. Hargreaves (2008). Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation. The Journal of Neuroscience,28(5):1064-1075
6.Bridges D, Rice AS, Egertova'M, Elphick MR, Winter J, Michael GJ. Localization of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridization and immunohistochemistry. Neuroscience 119:803-812,2003.
7.Binzen U, Greffrath W, Hennessy S, Bausen M, Saaler-Reinhardt S, Treede RD. Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. Neuroscience 142:527-539,2006.
8.Beatriz Fioravanti, Milena De Felice, Cheryl L. Stucky, Karen A. Medler, Miaw-Chyi Luo, Luis R. Gardell, Mohab Ibrahim, T. Phil Malan Jr, Henry I. Yamamura, Michael H. Ossipov, Tamara King, Josephine Lai, Frank Porreca, and Todd W. Vanderah (2008) Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious CB1 inverse agonists. J Neurosci.28(45):11593-11602.
9.Bhave, G., Hu, H.-J., Glauner, K. S., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S.& Gereau, R. W., Ⅳ (2003) Proc. Natl. Acad. Sci. USA 100,12480-12485.
lO.Bhave, G., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S.& Gereau, R. W., Ⅳ(2002) Neuron 35,721-731.
11.Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000;288:306-313.
12.Caterina M, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor:a heat-activated ion channel in the pain pathway. Nature 1997;389:816-824
13.Calignano A, La Rana G, Giuffrida A, Piomelli D (1998) Control of pain initiation by endogenous cannabinoids. Nature 394:277-281.
14.Croxford JL (2003) Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 17:179-202.
15.Cesare P, McNaughton P. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin.Proc Natl Acad Sci USA 93:15435-15439,1996.
16.Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183-187,2000.
17.deCharms RC, Maeda F, Glover GH, Ludlow D, Pauly JM, Soneji D, Gabrieli JD, Mackey SC. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci USA 102:18626-18631,2005.
18.DE PETROCELLIS, L., BISOGNO, T., MACCARRONE, M., DAVIS, J.B., FINAZZI-AGRO, A.& DI MARZO, V. (2001). The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem.,276,12856-12863.
19.FOX, A., KESINGLAND, A., GENTRY, C, MCNAIR, K., PATEL, S., URBAN, L.& JAMES, I. (2001). The role of central and peripheral cannabinoid 1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain,92, 91-100.
20.Greffrath W, Binzen U, Schwarz ST, Saaler-Reinhardt S, Treede RD. Co-expression of heat sensitive vanilloid receptor subtypes in rat dorsal root ganglion neurons. Neuroreport 14:2251-2255,2003.
21.Guo, J.& Schofield, G. G. (2002) J. Physiol. (London) 545,767-781.
22.Hohmann AG, Herkenham M. Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia:a double-label in situ hybridization study. Neuroscience 90:923-931,1999.
23.Hermann H, De Petrocellis L, Bisogno T, Schiano Moriello A, Lutz B, Di Marzo V. Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. Cell Mol Life Sci 60:607-616,2003.
24.Ho BY, Current L, Drewett JG. Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16). FEBS Lett 2002;522:130-134.
25.Ho BY, Uezono Y, Takada S, Takase I, Izumi F. Coupling of the expressed cannabinoid CB1 and CB2 receptors to phospholipase C and G protein-coupled inwardly rectifying K+ channels. Receptors Channels 1999;6:363-374.
26.IVERSEN, L.& CHAPMAN, V. (2002). Cannabinoids:a real prospect for pain relief? Curr. Opin. Pharmacol.,2,50-55.
27.Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan Jr TP (2006) CB(2) cannabinoid receptor mediation of antinociception. Pain 122:36-42.
28.JUNG, J., HWANG, S.W., KWAK, J., LEE, S.Y., KANG, C.J., KIM, W.B., KIM, D.& OH, U. (1999). Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J. Neurosci.,19,529-538.
29.JORDT, S.E.& JULIUS, D. (2002). Molecular basis for species specificity to'hot'chili peppers. Cell,108,421-430.
30.Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM (2006). Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem 281:32879-32890.
31.Koplas PA, Rosenberg RL, Oxford GS. The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci 1997;17:3525-3537.
32.KHASABOVA, I.A., SIMONE, D.A.& SEYBOLD, V.S. (2002). Cannabinoids attenuate depolarisation-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats. Neuroscience,115,613-625.
33.Lie Chen, Changjin Liu, Lieju Liu (2008). The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons. Neuroscience.154(2): 482-495.
34.Lei Chen, Changjin Liu, Lieju Liu, Xuehong Cao. Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons. Neuroscience Research 64(2009)199-207
35.Liu L, Simon SA. Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. JNeurophysiol 75:1503-1514,1996.
36.Liu B, Zhang C, Qin F. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. J Neurosci 25: 4835-4843,2005.
37.Ledent, C. et al. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283,401-404
38.Lopshire JC, Nicol GD. The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons:whole-cell and single-channel studies. J Neurosci 18:6081-6092,1998.
39.Melanie R. Lalonde, Christine A.B Jollimore, Kelly Stevens, Steven Barnes, Melanie E.M. Kelly (2006). Cannabinoid receptor-mediated inhibition of calcium signaling in rat retinal ganglion cells. Molecular Vision 12:1160-6
40.Martin BR, Compton DR, Thomas BF, et al. Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs. Pharmacol Biochem Behav.1991; 40: 471-478
41.Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
42.Munro S, Thomas KL, Abu-Shaar M (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65.
43.Millns PJ, Chapman V, Kendall DA (2001). Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones. Br J Pharmacol 132:969-971.
44.Malan Jr TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F (2003) CB2 cannabinoid receptor agonists:pain relief without psychoactive effects? Curr Opin Pharmacol 3:62-67.
45.Mohapatra DP, Nau C. Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 2005;280:13424-13432.
46.Marshall IC, Owen DE, Cripps TV, Davis JB, McNulty S, Smart D. Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-trisphosphate-sensitive stores. Br JPharmacol 138:172-176,2003.
47.Mao J, Price DD, Lu J, Keniston L, Mayer DJ. Two distinctive antinociceptive systems in rats with pathological pain. Neurosci Lett.2000; 280:13-16
48.Mohapatra, D. P.& Nau, C. (2003) J. Biol. Chem.278,50080-50090.
49.Mechoulam R, Fride E, Di Marzo V (1998). Endocannabinoids. Eur J Pharmacol 359:1-18.
50.Netzeband JG, Conroy SM, Parsons KL, Gruol DL (1999). Cannabinoids enhance NMDA-elicited Ca2t signals in cerebellar granule neurons in culture. J Neurosci 19: 8765-8777.
51.Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T. and Ueda, N. (2004) Molecular characterization of a phospholipase D generating anandamide and its congeners. Journal of Biological Chemistry 279,5298-5305.
52.PRICE, T.J., HELESIC, G., PARGHI, D., HARGREAVES, K.M.& FLORES, C.M. (2003). The neuronal distribution of cannabinoid receptor type one in the trigeminal ganglion of the rat. Neuroscience,120,155-162.
53.Price, T. J., Patwardhan, A. M., Akopian, A. N., Hargreaves, K. M.& Flores, C. M. (2004) Br. J. Pharmacol.141,1118-1130.
54.Patwardhan AM, Jeske NA, Price TJ, Gamper N, Akopian AN, Hargreaves KM (2006) The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci USA 103:11393-11398.
55.Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol 168: 1-51,2005.
56.PERTWEE, R.G.& ROSS, R.A. (2002). Cannabinoid receptors and their ligands. Prostagland. Leukotr. Essent. Fatty Acids,66,101-121.
57.PERTWEE, R.G. (2004). Novel pharmacological targets for cannabinoids. Curr. Neuropharmacol.,2,9-29.
58.Pertwee RG (2001). Cannabinoid receptors and pain. Prog Neurobiol 63:569-611.
59.Pacher, P. et al. (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol. Rev.58,389-462
60.Piomelli, D. (2003) The molecular logic of endocannabinoid signalling. Nature Reviews Neuroscience 4,873-884.
61.Premkumar LS, Ahern GP. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408:985-990,2000.
62.Pop E (1999). Cannabinoids endogenous ligands and synthetic analogs. Curr Opin Chem Biol 3:418-425.
63.Richardson JD, Kilo S, Hargreaves KM (1998) Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75:111-119.
64.Rice ASC, Farquhar-Smith WP, and Nagy I (2002) Endocannabinoids and pain:spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukotrienes Essent Fatty Acids 66:243-256.
65.ROSS, R.A. (2003). Anandamide and vanilloid TRPV1 receptors. Br. J. Pharmacol.,140, 790-801.
66.Rhian M. Evans, Roderick H. Scott, Ruth A. Ross (2004). Multiple actions of anandamide on neonatal rat cultured sensory neurons. British Journal of Pharmacology 141,1223-1233
67.Riddall DR, Leach MJ, Garthwaite J. A novel drug binding site on voltage-gated sodium channels in rat brain. Mol Pharmacol 69:278-287,2006.
68.Sarfaraz S, Afaq F, Adhami VM, Mukhtar H (2005). Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 65:1635-1641.
69.Stella, N., Schweitzer, P. and Piomelli, D. (1997) A second endogenous cannabinoid that modulates long-term potentiation. Nature 388,773-778.
70.Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999;51:159-212.
71.Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1:10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 2007;6:357-72.
72.Smart D, Jerman JC, Gunthorpe MJ, et al. Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology. Eur J Pharmacol 2001; 417:51-8
73.Starowicz K, Nigam S, Di Marzo V (2007). Biochemistry and pharmacology of endovanilloids. Pharmacol Ther 114:13-33.
74.Theodore J.Price, Amol Patwardhan, et al.. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. British Journal of Pharmacology (2004) 142,257-266
75.Tilo Fischbach, Wolfgang Greffrath, Hermann Nawrath, Rolf-Detlef Treede (2007). Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats. J Neurophysiol 98:929-938
76.Vladimir V. Matchkov, Christian Aalkjaer, Holger Nilsson(2004). A Cyclic GMP-dependent Calcium-activated Chloride Current in Smooth-muscle Cells from Rat Mesenteric Resistance Arteries. J. Gen. Physiol.123,121-134
77.van der Stelt M, Di Marzo V. Endovanilloids:putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem 2004;271:1827-1834.
78.Walker JM, Hohmann AG. Cannabinoid mechanisms of pain suppression. Handb Exp Pharmacol 168:509-554,2005.
79.Walker JM, Huang SM (2002). Cannabinoid analgesia. Pharmacol Ther 95:127-135
80.Hohmann AG, Suplita Ⅱ RL (2006). Endocannabinoid mechanisms of pain modulation. AAPS J 8:E693-708.
81.Zimmer, A. et al. (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc. Natl. Acad. Sci. U. S. A.96, 5780-5785
82.ZYGMUNT, P.M., PETERSSON, J., ANDERSSON, D.A., CHUANG, H., SFRGA°RD, M., DI MARZO, V., JULIUS, D.& HO" GESTA" TT, E.D. (1999). Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature,400, 452-457.
1.Hu W P, Guan B C, Ru L Q, et al. Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptor in trigeminal ganglion neurons of rats[J].Neuropharmacol,2004,47:8332840.
2.胡旺平,李之望,茹立强,樊友珍。大鼠三叉神经节神经元5-羟色胺激活电流及其特征。神经解剖学杂志,2004；20(6)533-556..
3.FAN, P. (1995). Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurones. J. Neurophysiol.,73,907±910.
4.Lie Chen, Changjin Liu, Lieju Liu (2008). The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons. Neuroscience.154(2): 482-495.
5.Lei Chen, Changjin Liu, Lieju Liu, Xuehong Cao. Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons. Neuroscience Research 64(2009)199-207
6.Liu L, Simon SA. Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. J Neurophysiol 75:1503-1514,1996.
7.Hu W P, Guan B C, Ru L Q, et al. Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptor in trigeminal ganglion neurons of rats[J].Neuropharmacol,2004,47:8332840.
8.Chen J J, Vasko M R, Wu X P, et al. Multiple sub-types of serotonin receptors are expressed in rat sensory neurons in culture [J]. J Pharmacol Ex p Ther,1998,287: 111921127.
9.Chen J J, Vasko M R, Wu X P, et al. Multiple sub—ypes of serotonin receptors are expressed in rat sensory neurons in culture [J]. J Pharmacol Ex p Ther,1998,287 111921127.
10.Zhu M, Wu S X, Wang W, et al. Expression of 5—HT receptor subtype mRNAs in the rat trigeminal and spinal dorsal root ganglia2a polymerase chain reaction study[J]. Chin J Neuroanat,2000,16:107211
11.Mackowiak M, et al:Psychiatria Polska,2000; 34(4):607—621.
12.Shimron—abarbanell D, et al:American Journal of Medical Genetics,1996,67(2): 225—228.
13.Maricq AV, Peterson AS, Brake AJ, et al. Primary structure and functional exp ression of the 5HT3 recep tor, a serotonin2gated ion channel[J]. Science,1991,254 (5030): 4322437.
14.Davies PA, PistisM, HannaMC, et al. The 5-HT3B subunit is ama2 jor determinant of serotonin recep tor function[J]. N ature,1999,397 (6717):3592363.
15.MoralesM,Wang SD. Differential composition of 52hydroxytryp ta2 mine3 recep tors synthesized in the rat CNS and peripheral nervous system[J]. N euroscience,2002, 22 (15):673226741.
16.Adrienne E,Dubin J, Huvar R, et al. The pharmacological and func2 tional characteristics of the serotonin 52HT3A recep tor are specifically modifiedby a 52HT3B recep tor subunit [J]. B iol Chem,1999,274 (43):30799230810.
17.NiemeyerM I, Lummis SCR. The role of the agonist binding site in Ca2+inhibition of the recombinant 52HT3A recep tor[J]. Eur J Phar2 m acol,2001,428 (2):1532161.
18.Hubbard PC, Lummis SCR. Zn2+enhancement of the recombinant 52HT3 recep tor ismodulated by divalent cations[J]. Eur J Pharm a2 col,2000,394 (223):1892197.
19.Sung K, Engel SR, Allan AM, et al.52HT (3) recep tor function and potentiation by alcohols in frontal cortex neurons from transgenic mice overexp ressing the recep tor [J]. N europharm acol,2000,39 (12),234622351.
20.Wetzel CH, Hermann B, Behl C, et al. Functional antagonism of go2 nadal steroids at the 52hydroxytryp taminetype3 recep tor[J]. M ol En2 docrinol,1998,12 (9) 144121451.
21.Wolf H. Preclinical and clinical pharmacology of the 52HT3 recep tor antagonists[J]. Scand J Rheum atol Suppl,2000,29 (4):37245.
22.Grunberg SM, Koeller JM. Palonosetron:a unique 52HT3 2recep tor antagonist for the p revention of chemotherapy2induced emesis [J]. Expert Opin Pharm acother,2003,4 (12):229722303.
23.Carley DW, Depoortere H, RadulovackiM, et al. R2zacop ride, a 52 HT3 antagonist /52HT4 agonist, reduces sleep apneas in rats [J]. Pharm acol B iochem B ehav,2001, 69(122):2832289.
24.Carley DW, RadulovackiM. Role of peripheral serotonin in the regu2 lation of central sleep apneas in rats [J]. Chest,1999,115(5):139721401.182
25.Yoshimoto K, McBrideWJ. Alcohol stimulates the release of dopa2 mine and serotonin in the nucleus accumbens[J]. A lcohol,1992,9 (1):17222.
26.Johnson BA, Roache JD, Ait2Daoud N, et al. Ondansetron reduces the craving of biologically p redisposed alcoholics[J]. Psychopharm a2 col (B erl),2002,160 (4): 4082413.
27.Spath M. Current experience with 52HT3 recep tor antagonists in fi2 bromyalgia[J]. Rheum D is Clin N orth Am,2002,28 (2):3192328.
28.Liedtke w, Choe Y, Marti-renom MA, et al. Vanllioid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell,2000, 103:525-535.
29.Okada T, Inoue R, Yamazaki K, et al.Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7 Ca2+ permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-couled receptor. J Biol Chem,1999,274:27359-27370.
30. Guler A,Lee H,Benham C D,Randall A, et al. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci,2002,23:183-191.
31. Caterina M, Schumacher M A, Tominaga M, et al. The capsaicin receptor:a heat-activated ion channel in the pain pathway. Nature,1997,389:816-824.
32. Carstens E, Kuenzler N, and Handwerker HO. Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa. J Neurophysiol 80:465-492,1998.
33.Green BG, and Gelhard B. Salt as an oral irritant. Chem Senses 14:259-271,1989.
34.Wang Y, Erickson RP, and Simon SA. Selectivity of lingual nerve fibers to chemical stimuli. J Gen Physiol 128:491-493,2006.
1.AHLUWALIA, J., URBAN, L., BEVAN, S., CAPOGNA, M.& NAGY, I. (2002). Cannabinoid 1 receptors are expressed by nerve growth factor-and glial cell-derived neurotrophic factor-responsive primary sensory neurones. Neuroscience,110, 747-753.
2.Ahluwalia J, Urban L, Capogna M, Bevan S, Nagy I. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience 100:685-688,2000.
3.Amol M. Patwardhan, Nathaniel A. Jeske, Theodore J. Price, Nikita Gamper, Armen N. Akopian, and Kenneth M. Hargreaves (2006). The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. PNAS 103 (30):11393-11398
4.Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, et al. (2007) Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci10:870-879.
5.Armen N. Akopian, Nikita B. Ruparel, Amol Patwardhan, Kenneth M. Hargreaves (2008). Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation. The Journal of Neuroscience,28(5):1064-1075
6.Azad SC, Eder M, Marsicano G, et al. Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdale of the mouse. Learn Mem.2003;10(2):116-118.
7.Andreas G Spinal and peripheral mechanisms of cannabinoid antinociception:behavioral, neurophysiological and neuroanatomical perspectives. Chem. Phys. Lipid. 2002;121:173-190.
8.Bridges D, Rice AS, Egertova'M, Elphick MR, Winter J, Michael GJ. Localization of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridization and immunohistochemistry. Neuroscience 119:803-812,2003.
9.Binzen U, Greffrath W, Hennessy S, Bausen M, Saaler-Reinhardt S, Treede RD. Co-expression of the voltage-gated potassium channel Kvl.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. Neuroscience 142:527-539,2006.
10.Beatriz Fioravanti, Milena De Felice, Cheryl L. Stucky, Karen A. Medler, Miaw-Chyi Luo, Luis R. Gardell, Mohab Ibrahim, T. Phil Malan Jr, Henry I. Yamamura, Michael H. Ossipov, Tamara King, Josephine Lai, Frank Porreca, and Todd W. Vanderah (2008) Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious CB1 inverse agonists. JNeurosci.28(45):11593-11602.
11.Bhave, G., Hu, H.-J., Glauner, K. S., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S.& Gereau, R. W., IV (2003) Proc. Natl. Acad. Sci. USA 100,12480-12485.
12.Bhave, G., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S.& Gereau, R. W., IV (2002) Neuron 35,721-731.
13.Bouabula M, Poinot-Chazel C, Bourrie B, et al. Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. Biochem J. 1995;312:637-641.
14.Breivogel CS, Childers SR. The functional neuroanatomy of brain cannabinoid receptors. Neurobiol Dis.1998; 5:417-431.
15.Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000;288:306-313.
16.Caterina M, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor:a heat-activated ion channel in the pain pathway. Nature 1997;389:816-824
17.Calignano A, La Rana G, Giuffrida A, Piomelli D (1998) Control of pain initiation by endogenous cannabinoids. Nature 394:277-281.
18.Croxford JL (2003) Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 17:179-202.
19.Cesare P, McNaughton P. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc Natl Acad Sci USA 93:15435-15439,1996.
20.Christopher S, Breivogel, Steven R, et al. The functional neuroanatomy of brain cannabinoid receptors. Neurobiology of Disease.1998;5:417-431.
21.Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183-187,2000.
22.deCharms RC, Maeda F, Glover GH, Ludlow D, Pauly JM, Soneji D, Gabrieli JD, Mackey SC. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci USA 102:18626-18631,2005.
23.DE PETROCELLIS, L., BISOGNO, T., MACCARRONE, M., DAVIS, J.B., FINAZZI-AGRO, A.& DI MARZO, V. (2001). The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem.,276,12856-12863.
24.Devane WA, Dysarz FA, Johnson MR, et al. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol.1998; 34:605-613.
25.Deadwyler S, Hampson RE, Childers SR. Functional significance of cannabinoid receptors in brain. Academic Press.1995; 206-227.
26.Felder, CC, Joyce KE, Briley EM, et al. A novel cannabinoid CB1 receptor antagonist unmasks coupling of the CB1 receptor to stimulation of Camp accumulation. J Pharmacol Exp Ther. 1988; 284:291-297.
27.Felder CC, Joy KE, Briley EM, et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol.1995; 48:443-450.
28.FOX, A., KESINGLAND, A., GENTRY, C., MCNAIR, K., PATEL, S., URBAN, L.& JAMES, I. (2001). The role of central and peripheral cannabinoid 1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain,92, 91-100.
29.Greffrath W, Binzen U, Schwarz ST, Saaler-Reinhardt S, Treede RD. Co-expression of heat sensitive vanilloid receptor subtypes in rat dorsal root ganglion neurons. Neuroreport 14:2251-2255,2003.
30.Guo, J.& Schofield, G. G. (2002) J. Physiol (London) 545,767-781.
31.Glass M, Dragunow M, Faull RLM. Cannabinoid receptors in the human brain:a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 1997; 77:299-318.
32.Gerard CM, Molerau C, Vassart TM, et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J.1991; 279:129-134.
33.Gatley SJ, Lan R, Volkow ND, et al. Imaging of the brain marijuana receptor-development of a radio-ligand that binds to cannabinoid CB1 receptor in vivio. J Neurochem 1998; 70:417-423.
34.Goutopoulos A, Makriyannis A. From cannabis to cannabinergics:new therapeutic opportunities. Pharmcol Ther.2002;95:103-117.
35.Hohmann AG, Herkenham M. Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia:a double-label in situ hybridization study. Neuroscience 90:923-931,1999.
36.Hermann H, De Petrocellis L, Bisogno T, Schiano Moriello A, Lutz B, Di Marzo V. Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. Cell Mol Life Sci 60:607-616,2003.
37.Hohmann AG, Suplita Ⅱ RL (2006). Endocannabinoid mechanisms of pain modulation. AAPS J 8:E693-708.
38.Ho BY, Current L, Drewett JG. Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alphal6). FEBS Lett 2002;522:130-134.
39.Ho BY, Uezono Y, Takada S, Takase I, Izumi F. Coupling of the expressed cannabinoid CB1 and CB2 receptors to phospholipase C and G protein-coupled inwardly rectifying K+ channels. Receptors Channels 1999;6:363-374.
40.Herkenham M, Lynn AB, Little MD, et al. Cannabinoid receptor localization in brain. Pro Natl Acad Sci.1990;87:1932-1936.
41.Howlett AC. Song C, Berglund BA, et al. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed mutagenesis. Mol Pharmacol.1998;53:504-510
42.Howlett AC, Mukhopadhyay S, Shim JY, et al. Signal transduction of eicosanoid CB1 receptor ligands. Life Sci.1999; 65:617-625.
43.IVERSEN, L.& CHAPMAN, V. (2002). Cannabinoids:a real prospect for pain relief? Curr. Opin. Pharmacol.,2,50-55.
44.Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan Jr TP (2006) CB(2) cannabinoid receptor mediation of antinociception. Pain 122:36-42.
45.JUNG, J., HWANG, S.W., KWAK, J., LEE, S.Y., KANG, C.J., KIM, W.B., KIM, D.& OH, U. (1999). Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J. Neurosci.,19,529-538.
46 JORDT, S.E.& JULIUS, D. (2002). Molecular basis for species specificity to'hot'chili peppers. Cell,108,421-430.
47.Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM (2006). Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem 281:32879-32890.
48.Kearn CS, Hillard CJ. A model for the study of cannabinoid actions in microglia 1999; p.44.
49.Koplas PA, Rosenberg RL, Oxford GS. The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci 1997;17:3525-3537.
50.KHASABOVA, I.A., SIMONE, D.A.& SEYBOLD, V.S. (2002). Cannabinoids attenuate depolarisation-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats. Neuroscience,115,613-625.
51.Lie Chen, Changjin Liu, Lieju Liu (2008). The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons. Neuroscience.154(2): 482-495.
52.Lei Chen, Changjin Liu, Lieju Liu, Xuehong Cao. Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons. Neuroscience Research 64(2009)199-207
53.Liu L, Simon SA. Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. JNeurophysiol 75:1503-1514,1996.
54.Liu B, Zhang C, Qin F. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. JNeurosci 25: 4835-4843,2005.
55.Ledent, C. et al. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283,401-404
56.Lopshire JC, Nicol GD. The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons:whole-cell and single-channel studies. J Neurosci 18:6081-6092,1998.
57.Lichtman AH, Martin BR. Spinal and supraspinal components of cannabinoid-induced antinociception. J. Pharmacol. Exp. Ther.1991;258:517-523.
58.Lichtman AH, Cook SA, Martin BR. Investigation of brain sites mediating cannabinoid-induced antinociception in rats:evidence supporting periaqueductal gray involvement. J Pharmacol Exp Ther.1996; 276:585-593.
59.Melanie R. Lalonde, Christine A.B Jollimore, Kelly Stevens, Steven Barnes, Melanie E.M. Kelly (2006). Cannabinoid receptor-mediated inhibition of calcium signaling in rat retinal ganglion cells. Molecular Vision 12:1160-6
60.Martin BR, Compton DR, Thomas BF, et al. Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs. Pharmacol Biochem Behav.1991; 40: 471-478
61.Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
62.Munro S, Thomas KL, Abu-Shaar M (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65.
63.Millns PJ, Chapman V, Kendall DA (2001). Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones. Br J Pharmacol 132:969-971.
64.Malan Jr TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F (2003) CB2 cannabinoid receptor agonists:pain relief without psychoactive effects? Curr Opin Pharmacol 3:62-67.
65.Mohapatra DP, Nau C. Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 2005;280:13424-13432.
66.Marshall IC, Owen DE, Cripps TV, Davis JB, McNulty S, Smart D. Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-trisphosphate-sensitive stores. Br JPharmacol 138:172-176,2003.
67.Mao J, Price DD, Lu J, Keniston L, Mayer DJ. Two distinctive antinociceptive systems in rats with pathological pain. Neurosci Lett.2000; 280:13-16
68.Mohapatra, D. P.& Nau, C. (2003) J. Biol. Chem.278,50080-50090.
69.Mechoulam R, Fride E, Di Marzo V (1998). Endocannabinoids. Eur J Pharmacol 359:1-18.
70.Mu J, Zhuang SY, Kirby MT, et al. Cannabinoid receptors differentially modulate potassium A and D currents in hippocampal neurons. J Pharmcol Exp Ther.1999; 291:893-902.
71. Martin WJ, Tsou K, Walker JM. Cannabinoid receptor mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla. Neurosci. Lett.1998; 242:33-36.
72. Martin WJ, Coffin PO, Attias E, et al. Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections. Brin Res.1999; 822:237-242.
73 Martin WJ, Lai NK, Patrick SL, et al. Antinociceptive actions of cannabinoids following intraventricular administration in rats. Brain Res.1993;629:300-304.
74.Nicholson RA, Liao C, Zheng J, et al. Sodium channel inhibition by anandemide and synthetic annabimimetics in brain. Brain Res.2003; 978(1-2):194-204.
75.Netzeband JG, Conroy SM, Parsons KL, Gruol DL (1999). Cannabinoids enhance NMDA-elicited Ca2t signals in cerebellar granule neurons in culture. J Neurosci 19: 8765-8777.
76.Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T. and Ueda, N. (2004) Molecular characterization of a phospholipase D generating anandamide and its congeners. Journal of Biological Chemistry 279,5298-5305.
77.PRICE, T.J., HELESIC, G., PARGHI, D., HARGREAVES, K.M.& FLORES, C.M. (2003). The neuronal distribution of cannabinoid receptor type one in the trigeminal ganglion of the rat. Neuroscience,120,155-162.
78.Price, T. J., Patwardhan, A. M., Akopian, A. N., Hargreaves, K. M.& Flores, C. M. (2004) Br. J. Pharmacol.141,1118-1130.
79.Patwardhan AM, Jeske NA, Price TJ, Gamper N, Akopian AN, Hargreaves KM (2006) The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci USA 103:11393-11398.
80.Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol 168: 1-51,2005.
81.PERTWEE, R.G.& ROSS, R.A. (2002). Cannabinoid receptors and their ligands. Prostagland. Leukotr. Essent. Fatty Acids,66,101-121.
82.PERTWEE, R.G. (2004). Novel pharmacological targets for cannabinoids. Curr. Neuropharmacol.,2,9-29.
83.Pertwee RG (2001). Cannabinoid receptors and pain. Prog Neurobiol 63:569-611.
84.Pacher, P. et al. (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol. Rev.58,389-462
85.Piomelli, D. (2003) The molecular logic of endocannabinoid signalling. Nature Reviews Neuroscience 4,873-884.
86.Premkumar LS, Ahern GP. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408:985-990,2000.
87.Pop E (1999). Cannabinoids endogenous ligands and synthetic analogs. Curr Opin Chem Biol 3:418-425.
88.Richardson JD, Kilo S, Hargreaves KM (1998) Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75:111-119.
89.Rice ASC, Farquhar-Smith WP, and Nagy Ⅰ (2002) Endocannabinoids and pain:spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukotrienes Essent Fatty Acids 66:243-256.
90.ROSS, R.A. (2003). Anandamide and vanilloid TRPV1 receptors. Br. J. Pharmacol.,140, 790-801.
91.Rhian M. Evans, Roderick H. Scott, Ruth A. Ross (2004). Multiple actions of anandamide on neonatal rat cultured sensory neurons. British Journal of Pharmacology 141,1223-1233
92.Riddall DR, Leach MJ, Garthwaite J. A novel drug binding site on voltage-gated sodium channels in rat brain. Mol Pharmacol 69:278-287,2006.
93.Sarfaraz S, Afaq F, Adhami VM, Mukhtar H (2005). Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 65:1635-1641.
94.Stella, N., Schweitzer, P. and Piomelli, D. (1997) A second endogenous cannabinoid that modulates long-term potentiation. Nature 388,773-778.
95.Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999;51:159-212.
96.Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1:10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 2007;6:357-72.
97.Smart D, Jerman JC, Gunthorpe MJ, et al. Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology. Eur J Pharmacol 2001; 417:51-8
98.Starowicz K, Nigam S, Di Marzo V (2007). Biochemistry and pharmacology of endovanilloids. Pharmacol Ther 114:13-33.
99.Skaper SD, Buriani A, DalToso R, et al. The ALIAmid palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Nat Acad Sci.1996; 93:3984-3989.
100.Schweitzer P. Cannabinoids decrease the K(+) M-current in hippocampal CA1 neurons. JNeurosi.2000; 20:51-58.
101.Theodore J.Price, Amol Patwardhan, et al.. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. British Journal of Pharmacology (2004) 142,257-266
102.Tilo Fischbach, Wolfgang Greffrath, Hermann Nawrath, Rolf-Detlef Treede (2007). Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats. J Neurophysiol 98:929-938
103.Twitchell W, Brown S, Mackie K. Cannbinoids inhibit N-and P/O-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol.1997;78:43-50.
104.Vladimir V. Matchkov, Christian Aalkjaer, Holger Nilsson(2004). A Cyclic GMP-dependent Calcium-activated Chloride Current in Smooth-muscle Cells from Rat Mesenteric Resistance Arteries. J. Gen. Physiol.123,121-134
105.van der Stelt M, Di Marzo V. Endovanilloids:putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem 2004;271:1827-1834.
106.Walker JM, Hohmann G, Martin WJ, et al. The neurobiology of cannabinoid analgesia. Life Sci.1999;65:665-673.
107. Walker JM, Hohmann AG. Cannabinoid mechanisms of pain suppression. Handb Exp Pharmacol 168:509-554,2005.
108.Walker JM, Huang SM (2002). Cannabinoid analgesia. Pharmacol Ther 95:127-135
109.Zimmer, A. et al. (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc. Natl. Acad. Sci. U. S. A.96, 5780-5785
11O.ZYGMUNT, P.M., PETERSSON, J., ANDERSSON, D.A., CHUANG, H., SFRGA0 RD, M., DI MARZO, V., JULIUS, D.& HO" GESTA" TT, E.D. (1999). Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature,400, 452-457.
2.Ahluwalia J, Urban L, Capogna M, Bevan S, Nagy I. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience 100:685-688,2000.
3.Amol M. Patwardhan, Nathaniel A. Jeske, Theodore J. Price, Nikita Gamper, Armen N. Akopian, and Kenneth M. Hargreaves (2006). The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. PNAS 103 (30):11393-11398
4.Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, et al. (2007) Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci10:870-879.
5.Armen N. Akopian, Nikita B. Ruparel, Amol Patwardhan, Kenneth M. Hargreaves (2008). Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation. The Journal of Neuroscience,28(5):1064-1075
6.Bridges D, Rice AS, Egertova'M, Elphick MR, Winter J, Michael GJ. Localization of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridization and immunohistochemistry. Neuroscience 119:803-812,2003.
7.Binzen U, Greffrath W, Hennessy S, Bausen M, Saaler-Reinhardt S, Treede RD. Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. Neuroscience 142:527-539,2006.
8.Beatriz Fioravanti, Milena De Felice, Cheryl L. Stucky, Karen A. Medler, Miaw-Chyi Luo, Luis R. Gardell, Mohab Ibrahim, T. Phil Malan Jr, Henry I. Yamamura, Michael H. Ossipov, Tamara King, Josephine Lai, Frank Porreca, and Todd W. Vanderah (2008) Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious CB1 inverse agonists. J Neurosci.28(45):11593-11602.
9.Bhave, G., Hu, H.-J., Glauner, K. S., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S.& Gereau, R. W., Ⅳ (2003) Proc. Natl. Acad. Sci. USA 100,12480-12485.
lO.Bhave, G., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S.& Gereau, R. W., Ⅳ(2002) Neuron 35,721-731.
11.Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000;288:306-313.
12.Caterina M, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor:a heat-activated ion channel in the pain pathway. Nature 1997;389:816-824
13.Calignano A, La Rana G, Giuffrida A, Piomelli D (1998) Control of pain initiation by endogenous cannabinoids. Nature 394:277-281.
14.Croxford JL (2003) Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 17:179-202.
15.Cesare P, McNaughton P. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin.Proc Natl Acad Sci USA 93:15435-15439,1996.
16.Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183-187,2000.
17.deCharms RC, Maeda F, Glover GH, Ludlow D, Pauly JM, Soneji D, Gabrieli JD, Mackey SC. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci USA 102:18626-18631,2005.
18.DE PETROCELLIS, L., BISOGNO, T., MACCARRONE, M., DAVIS, J.B., FINAZZI-AGRO, A.& DI MARZO, V. (2001). The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem.,276,12856-12863.
19.FOX, A., KESINGLAND, A., GENTRY, C, MCNAIR, K., PATEL, S., URBAN, L.& JAMES, I. (2001). The role of central and peripheral cannabinoid 1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain,92, 91-100.
20.Greffrath W, Binzen U, Schwarz ST, Saaler-Reinhardt S, Treede RD. Co-expression of heat sensitive vanilloid receptor subtypes in rat dorsal root ganglion neurons. Neuroreport 14:2251-2255,2003.
21.Guo, J.& Schofield, G. G. (2002) J. Physiol. (London) 545,767-781.
22.Hohmann AG, Herkenham M. Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia:a double-label in situ hybridization study. Neuroscience 90:923-931,1999.
23.Hermann H, De Petrocellis L, Bisogno T, Schiano Moriello A, Lutz B, Di Marzo V. Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. Cell Mol Life Sci 60:607-616,2003.
24.Ho BY, Current L, Drewett JG. Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16). FEBS Lett 2002;522:130-134.
25.Ho BY, Uezono Y, Takada S, Takase I, Izumi F. Coupling of the expressed cannabinoid CB1 and CB2 receptors to phospholipase C and G protein-coupled inwardly rectifying K+ channels. Receptors Channels 1999;6:363-374.
26.IVERSEN, L.& CHAPMAN, V. (2002). Cannabinoids:a real prospect for pain relief? Curr. Opin. Pharmacol.,2,50-55.
27.Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan Jr TP (2006) CB(2) cannabinoid receptor mediation of antinociception. Pain 122:36-42.
28.JUNG, J., HWANG, S.W., KWAK, J., LEE, S.Y., KANG, C.J., KIM, W.B., KIM, D.& OH, U. (1999). Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J. Neurosci.,19,529-538.
29.JORDT, S.E.& JULIUS, D. (2002). Molecular basis for species specificity to'hot'chili peppers. Cell,108,421-430.
30.Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM (2006). Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem 281:32879-32890.
31.Koplas PA, Rosenberg RL, Oxford GS. The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci 1997;17:3525-3537.
32.KHASABOVA, I.A., SIMONE, D.A.& SEYBOLD, V.S. (2002). Cannabinoids attenuate depolarisation-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats. Neuroscience,115,613-625.
33.Lie Chen, Changjin Liu, Lieju Liu (2008). The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons. Neuroscience.154(2): 482-495.
34.Lei Chen, Changjin Liu, Lieju Liu, Xuehong Cao. Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons. Neuroscience Research 64(2009)199-207
35.Liu L, Simon SA. Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. JNeurophysiol 75:1503-1514,1996.
36.Liu B, Zhang C, Qin F. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. J Neurosci 25: 4835-4843,2005.
37.Ledent, C. et al. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283,401-404
38.Lopshire JC, Nicol GD. The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons:whole-cell and single-channel studies. J Neurosci 18:6081-6092,1998.
39.Melanie R. Lalonde, Christine A.B Jollimore, Kelly Stevens, Steven Barnes, Melanie E.M. Kelly (2006). Cannabinoid receptor-mediated inhibition of calcium signaling in rat retinal ganglion cells. Molecular Vision 12:1160-6
40.Martin BR, Compton DR, Thomas BF, et al. Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs. Pharmacol Biochem Behav.1991; 40: 471-478
41.Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
42.Munro S, Thomas KL, Abu-Shaar M (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65.
43.Millns PJ, Chapman V, Kendall DA (2001). Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones. Br J Pharmacol 132:969-971.
44.Malan Jr TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F (2003) CB2 cannabinoid receptor agonists:pain relief without psychoactive effects? Curr Opin Pharmacol 3:62-67.
45.Mohapatra DP, Nau C. Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 2005;280:13424-13432.
46.Marshall IC, Owen DE, Cripps TV, Davis JB, McNulty S, Smart D. Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-trisphosphate-sensitive stores. Br JPharmacol 138:172-176,2003.
47.Mao J, Price DD, Lu J, Keniston L, Mayer DJ. Two distinctive antinociceptive systems in rats with pathological pain. Neurosci Lett.2000; 280:13-16
48.Mohapatra, D. P.& Nau, C. (2003) J. Biol. Chem.278,50080-50090.
49.Mechoulam R, Fride E, Di Marzo V (1998). Endocannabinoids. Eur J Pharmacol 359:1-18.
50.Netzeband JG, Conroy SM, Parsons KL, Gruol DL (1999). Cannabinoids enhance NMDA-elicited Ca2t signals in cerebellar granule neurons in culture. J Neurosci 19: 8765-8777.
51.Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T. and Ueda, N. (2004) Molecular characterization of a phospholipase D generating anandamide and its congeners. Journal of Biological Chemistry 279,5298-5305.
52.PRICE, T.J., HELESIC, G., PARGHI, D., HARGREAVES, K.M.& FLORES, C.M. (2003). The neuronal distribution of cannabinoid receptor type one in the trigeminal ganglion of the rat. Neuroscience,120,155-162.
53.Price, T. J., Patwardhan, A. M., Akopian, A. N., Hargreaves, K. M.& Flores, C. M. (2004) Br. J. Pharmacol.141,1118-1130.
54.Patwardhan AM, Jeske NA, Price TJ, Gamper N, Akopian AN, Hargreaves KM (2006) The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci USA 103:11393-11398.
55.Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol 168: 1-51,2005.
56.PERTWEE, R.G.& ROSS, R.A. (2002). Cannabinoid receptors and their ligands. Prostagland. Leukotr. Essent. Fatty Acids,66,101-121.
57.PERTWEE, R.G. (2004). Novel pharmacological targets for cannabinoids. Curr. Neuropharmacol.,2,9-29.
58.Pertwee RG (2001). Cannabinoid receptors and pain. Prog Neurobiol 63:569-611.
59.Pacher, P. et al. (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol. Rev.58,389-462
60.Piomelli, D. (2003) The molecular logic of endocannabinoid signalling. Nature Reviews Neuroscience 4,873-884.
61.Premkumar LS, Ahern GP. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408:985-990,2000.
62.Pop E (1999). Cannabinoids endogenous ligands and synthetic analogs. Curr Opin Chem Biol 3:418-425.
63.Richardson JD, Kilo S, Hargreaves KM (1998) Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75:111-119.
64.Rice ASC, Farquhar-Smith WP, and Nagy I (2002) Endocannabinoids and pain:spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukotrienes Essent Fatty Acids 66:243-256.
65.ROSS, R.A. (2003). Anandamide and vanilloid TRPV1 receptors. Br. J. Pharmacol.,140, 790-801.
66.Rhian M. Evans, Roderick H. Scott, Ruth A. Ross (2004). Multiple actions of anandamide on neonatal rat cultured sensory neurons. British Journal of Pharmacology 141,1223-1233
67.Riddall DR, Leach MJ, Garthwaite J. A novel drug binding site on voltage-gated sodium channels in rat brain. Mol Pharmacol 69:278-287,2006.
68.Sarfaraz S, Afaq F, Adhami VM, Mukhtar H (2005). Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 65:1635-1641.
69.Stella, N., Schweitzer, P. and Piomelli, D. (1997) A second endogenous cannabinoid that modulates long-term potentiation. Nature 388,773-778.
70.Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999;51:159-212.
71.Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1:10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 2007;6:357-72.
72.Smart D, Jerman JC, Gunthorpe MJ, et al. Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology. Eur J Pharmacol 2001; 417:51-8
73.Starowicz K, Nigam S, Di Marzo V (2007). Biochemistry and pharmacology of endovanilloids. Pharmacol Ther 114:13-33.
74.Theodore J.Price, Amol Patwardhan, et al.. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. British Journal of Pharmacology (2004) 142,257-266
75.Tilo Fischbach, Wolfgang Greffrath, Hermann Nawrath, Rolf-Detlef Treede (2007). Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats. J Neurophysiol 98:929-938
76.Vladimir V. Matchkov, Christian Aalkjaer, Holger Nilsson(2004). A Cyclic GMP-dependent Calcium-activated Chloride Current in Smooth-muscle Cells from Rat Mesenteric Resistance Arteries. J. Gen. Physiol.123,121-134
77.van der Stelt M, Di Marzo V. Endovanilloids:putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem 2004;271:1827-1834.
78.Walker JM, Hohmann AG. Cannabinoid mechanisms of pain suppression. Handb Exp Pharmacol 168:509-554,2005.
79.Walker JM, Huang SM (2002). Cannabinoid analgesia. Pharmacol Ther 95:127-135
80.Hohmann AG, Suplita Ⅱ RL (2006). Endocannabinoid mechanisms of pain modulation. AAPS J 8:E693-708.
81.Zimmer, A. et al. (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc. Natl. Acad. Sci. U. S. A.96, 5780-5785
82.ZYGMUNT, P.M., PETERSSON, J., ANDERSSON, D.A., CHUANG, H., SFRGA°RD, M., DI MARZO, V., JULIUS, D.& HO" GESTA" TT, E.D. (1999). Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature,400, 452-457.
1.Hu W P, Guan B C, Ru L Q, et al. Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptor in trigeminal ganglion neurons of rats[J].Neuropharmacol,2004,47:8332840.
2.胡旺平,李之望,茹立强,樊友珍。大鼠三叉神经节神经元5-羟色胺激活电流及其特征。神经解剖学杂志,2004；20(6)533-556..
3.FAN, P. (1995). Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurones. J. Neurophysiol.,73,907±910.
4.Lie Chen, Changjin Liu, Lieju Liu (2008). The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons. Neuroscience.154(2): 482-495.
5.Lei Chen, Changjin Liu, Lieju Liu, Xuehong Cao. Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons. Neuroscience Research 64(2009)199-207
6.Liu L, Simon SA. Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. J Neurophysiol 75:1503-1514,1996.
7.Hu W P, Guan B C, Ru L Q, et al. Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptor in trigeminal ganglion neurons of rats[J].Neuropharmacol,2004,47:8332840.
8.Chen J J, Vasko M R, Wu X P, et al. Multiple sub-types of serotonin receptors are expressed in rat sensory neurons in culture [J]. J Pharmacol Ex p Ther,1998,287: 111921127.
9.Chen J J, Vasko M R, Wu X P, et al. Multiple sub—ypes of serotonin receptors are expressed in rat sensory neurons in culture [J]. J Pharmacol Ex p Ther,1998,287 111921127.
10.Zhu M, Wu S X, Wang W, et al. Expression of 5—HT receptor subtype mRNAs in the rat trigeminal and spinal dorsal root ganglia2a polymerase chain reaction study[J]. Chin J Neuroanat,2000,16:107211
11.Mackowiak M, et al:Psychiatria Polska,2000; 34(4):607—621.
12.Shimron—abarbanell D, et al:American Journal of Medical Genetics,1996,67(2): 225—228.
13.Maricq AV, Peterson AS, Brake AJ, et al. Primary structure and functional exp ression of the 5HT3 recep tor, a serotonin2gated ion channel[J]. Science,1991,254 (5030): 4322437.
14.Davies PA, PistisM, HannaMC, et al. The 5-HT3B subunit is ama2 jor determinant of serotonin recep tor function[J]. N ature,1999,397 (6717):3592363.
15.MoralesM,Wang SD. Differential composition of 52hydroxytryp ta2 mine3 recep tors synthesized in the rat CNS and peripheral nervous system[J]. N euroscience,2002, 22 (15):673226741.
16.Adrienne E,Dubin J, Huvar R, et al. The pharmacological and func2 tional characteristics of the serotonin 52HT3A recep tor are specifically modifiedby a 52HT3B recep tor subunit [J]. B iol Chem,1999,274 (43):30799230810.
17.NiemeyerM I, Lummis SCR. The role of the agonist binding site in Ca2+inhibition of the recombinant 52HT3A recep tor[J]. Eur J Phar2 m acol,2001,428 (2):1532161.
18.Hubbard PC, Lummis SCR. Zn2+enhancement of the recombinant 52HT3 recep tor ismodulated by divalent cations[J]. Eur J Pharm a2 col,2000,394 (223):1892197.
19.Sung K, Engel SR, Allan AM, et al.52HT (3) recep tor function and potentiation by alcohols in frontal cortex neurons from transgenic mice overexp ressing the recep tor [J]. N europharm acol,2000,39 (12),234622351.
20.Wetzel CH, Hermann B, Behl C, et al. Functional antagonism of go2 nadal steroids at the 52hydroxytryp taminetype3 recep tor[J]. M ol En2 docrinol,1998,12 (9) 144121451.
21.Wolf H. Preclinical and clinical pharmacology of the 52HT3 recep tor antagonists[J]. Scand J Rheum atol Suppl,2000,29 (4):37245.
22.Grunberg SM, Koeller JM. Palonosetron:a unique 52HT3 2recep tor antagonist for the p revention of chemotherapy2induced emesis [J]. Expert Opin Pharm acother,2003,4 (12):229722303.
23.Carley DW, Depoortere H, RadulovackiM, et al. R2zacop ride, a 52 HT3 antagonist /52HT4 agonist, reduces sleep apneas in rats [J]. Pharm acol B iochem B ehav,2001, 69(122):2832289.
24.Carley DW, RadulovackiM. Role of peripheral serotonin in the regu2 lation of central sleep apneas in rats [J]. Chest,1999,115(5):139721401.182
25.Yoshimoto K, McBrideWJ. Alcohol stimulates the release of dopa2 mine and serotonin in the nucleus accumbens[J]. A lcohol,1992,9 (1):17222.
26.Johnson BA, Roache JD, Ait2Daoud N, et al. Ondansetron reduces the craving of biologically p redisposed alcoholics[J]. Psychopharm a2 col (B erl),2002,160 (4): 4082413.
27.Spath M. Current experience with 52HT3 recep tor antagonists in fi2 bromyalgia[J]. Rheum D is Clin N orth Am,2002,28 (2):3192328.
28.Liedtke w, Choe Y, Marti-renom MA, et al. Vanllioid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell,2000, 103:525-535.
29.Okada T, Inoue R, Yamazaki K, et al.Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7 Ca2+ permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-couled receptor. J Biol Chem,1999,274:27359-27370.
30. Guler A,Lee H,Benham C D,Randall A, et al. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci,2002,23:183-191.
31. Caterina M, Schumacher M A, Tominaga M, et al. The capsaicin receptor:a heat-activated ion channel in the pain pathway. Nature,1997,389:816-824.
32. Carstens E, Kuenzler N, and Handwerker HO. Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa. J Neurophysiol 80:465-492,1998.
33.Green BG, and Gelhard B. Salt as an oral irritant. Chem Senses 14:259-271,1989.
34.Wang Y, Erickson RP, and Simon SA. Selectivity of lingual nerve fibers to chemical stimuli. J Gen Physiol 128:491-493,2006.
1.AHLUWALIA, J., URBAN, L., BEVAN, S., CAPOGNA, M.& NAGY, I. (2002). Cannabinoid 1 receptors are expressed by nerve growth factor-and glial cell-derived neurotrophic factor-responsive primary sensory neurones. Neuroscience,110, 747-753.
2.Ahluwalia J, Urban L, Capogna M, Bevan S, Nagy I. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience 100:685-688,2000.
3.Amol M. Patwardhan, Nathaniel A. Jeske, Theodore J. Price, Nikita Gamper, Armen N. Akopian, and Kenneth M. Hargreaves (2006). The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. PNAS 103 (30):11393-11398
4.Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, et al. (2007) Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci10:870-879.
5.Armen N. Akopian, Nikita B. Ruparel, Amol Patwardhan, Kenneth M. Hargreaves (2008). Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation. The Journal of Neuroscience,28(5):1064-1075
6.Azad SC, Eder M, Marsicano G, et al. Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdale of the mouse. Learn Mem.2003;10(2):116-118.
7.Andreas G Spinal and peripheral mechanisms of cannabinoid antinociception:behavioral, neurophysiological and neuroanatomical perspectives. Chem. Phys. Lipid. 2002;121:173-190.
8.Bridges D, Rice AS, Egertova'M, Elphick MR, Winter J, Michael GJ. Localization of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridization and immunohistochemistry. Neuroscience 119:803-812,2003.
9.Binzen U, Greffrath W, Hennessy S, Bausen M, Saaler-Reinhardt S, Treede RD. Co-expression of the voltage-gated potassium channel Kvl.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. Neuroscience 142:527-539,2006.
10.Beatriz Fioravanti, Milena De Felice, Cheryl L. Stucky, Karen A. Medler, Miaw-Chyi Luo, Luis R. Gardell, Mohab Ibrahim, T. Phil Malan Jr, Henry I. Yamamura, Michael H. Ossipov, Tamara King, Josephine Lai, Frank Porreca, and Todd W. Vanderah (2008) Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious CB1 inverse agonists. JNeurosci.28(45):11593-11602.
11.Bhave, G., Hu, H.-J., Glauner, K. S., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S.& Gereau, R. W., IV (2003) Proc. Natl. Acad. Sci. USA 100,12480-12485.
12.Bhave, G., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S.& Gereau, R. W., IV (2002) Neuron 35,721-731.
13.Bouabula M, Poinot-Chazel C, Bourrie B, et al. Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. Biochem J. 1995;312:637-641.
14.Breivogel CS, Childers SR. The functional neuroanatomy of brain cannabinoid receptors. Neurobiol Dis.1998; 5:417-431.
15.Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000;288:306-313.
16.Caterina M, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor:a heat-activated ion channel in the pain pathway. Nature 1997;389:816-824
17.Calignano A, La Rana G, Giuffrida A, Piomelli D (1998) Control of pain initiation by endogenous cannabinoids. Nature 394:277-281.
18.Croxford JL (2003) Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 17:179-202.
19.Cesare P, McNaughton P. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc Natl Acad Sci USA 93:15435-15439,1996.
20.Christopher S, Breivogel, Steven R, et al. The functional neuroanatomy of brain cannabinoid receptors. Neurobiology of Disease.1998;5:417-431.
21.Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183-187,2000.
22.deCharms RC, Maeda F, Glover GH, Ludlow D, Pauly JM, Soneji D, Gabrieli JD, Mackey SC. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci USA 102:18626-18631,2005.
23.DE PETROCELLIS, L., BISOGNO, T., MACCARRONE, M., DAVIS, J.B., FINAZZI-AGRO, A.& DI MARZO, V. (2001). The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem.,276,12856-12863.
24.Devane WA, Dysarz FA, Johnson MR, et al. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol.1998; 34:605-613.
25.Deadwyler S, Hampson RE, Childers SR. Functional significance of cannabinoid receptors in brain. Academic Press.1995; 206-227.
26.Felder, CC, Joyce KE, Briley EM, et al. A novel cannabinoid CB1 receptor antagonist unmasks coupling of the CB1 receptor to stimulation of Camp accumulation. J Pharmacol Exp Ther. 1988; 284:291-297.
27.Felder CC, Joy KE, Briley EM, et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol.1995; 48:443-450.
28.FOX, A., KESINGLAND, A., GENTRY, C., MCNAIR, K., PATEL, S., URBAN, L.& JAMES, I. (2001). The role of central and peripheral cannabinoid 1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain,92, 91-100.
29.Greffrath W, Binzen U, Schwarz ST, Saaler-Reinhardt S, Treede RD. Co-expression of heat sensitive vanilloid receptor subtypes in rat dorsal root ganglion neurons. Neuroreport 14:2251-2255,2003.
30.Guo, J.& Schofield, G. G. (2002) J. Physiol (London) 545,767-781.
31.Glass M, Dragunow M, Faull RLM. Cannabinoid receptors in the human brain:a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 1997; 77:299-318.
32.Gerard CM, Molerau C, Vassart TM, et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J.1991; 279:129-134.
33.Gatley SJ, Lan R, Volkow ND, et al. Imaging of the brain marijuana receptor-development of a radio-ligand that binds to cannabinoid CB1 receptor in vivio. J Neurochem 1998; 70:417-423.
34.Goutopoulos A, Makriyannis A. From cannabis to cannabinergics:new therapeutic opportunities. Pharmcol Ther.2002;95:103-117.
35.Hohmann AG, Herkenham M. Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia:a double-label in situ hybridization study. Neuroscience 90:923-931,1999.
36.Hermann H, De Petrocellis L, Bisogno T, Schiano Moriello A, Lutz B, Di Marzo V. Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. Cell Mol Life Sci 60:607-616,2003.
37.Hohmann AG, Suplita Ⅱ RL (2006). Endocannabinoid mechanisms of pain modulation. AAPS J 8:E693-708.
38.Ho BY, Current L, Drewett JG. Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alphal6). FEBS Lett 2002;522:130-134.
39.Ho BY, Uezono Y, Takada S, Takase I, Izumi F. Coupling of the expressed cannabinoid CB1 and CB2 receptors to phospholipase C and G protein-coupled inwardly rectifying K+ channels. Receptors Channels 1999;6:363-374.
40.Herkenham M, Lynn AB, Little MD, et al. Cannabinoid receptor localization in brain. Pro Natl Acad Sci.1990;87:1932-1936.
41.Howlett AC. Song C, Berglund BA, et al. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed mutagenesis. Mol Pharmacol.1998;53:504-510
42.Howlett AC, Mukhopadhyay S, Shim JY, et al. Signal transduction of eicosanoid CB1 receptor ligands. Life Sci.1999; 65:617-625.
43.IVERSEN, L.& CHAPMAN, V. (2002). Cannabinoids:a real prospect for pain relief? Curr. Opin. Pharmacol.,2,50-55.
44.Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan Jr TP (2006) CB(2) cannabinoid receptor mediation of antinociception. Pain 122:36-42.
45.JUNG, J., HWANG, S.W., KWAK, J., LEE, S.Y., KANG, C.J., KIM, W.B., KIM, D.& OH, U. (1999). Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J. Neurosci.,19,529-538.
46 JORDT, S.E.& JULIUS, D. (2002). Molecular basis for species specificity to'hot'chili peppers. Cell,108,421-430.
47.Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM (2006). Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem 281:32879-32890.
48.Kearn CS, Hillard CJ. A model for the study of cannabinoid actions in microglia 1999; p.44.
49.Koplas PA, Rosenberg RL, Oxford GS. The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci 1997;17:3525-3537.
50.KHASABOVA, I.A., SIMONE, D.A.& SEYBOLD, V.S. (2002). Cannabinoids attenuate depolarisation-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats. Neuroscience,115,613-625.
51.Lie Chen, Changjin Liu, Lieju Liu (2008). The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons. Neuroscience.154(2): 482-495.
52.Lei Chen, Changjin Liu, Lieju Liu, Xuehong Cao. Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons. Neuroscience Research 64(2009)199-207
53.Liu L, Simon SA. Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. JNeurophysiol 75:1503-1514,1996.
54.Liu B, Zhang C, Qin F. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. JNeurosci 25: 4835-4843,2005.
55.Ledent, C. et al. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283,401-404
56.Lopshire JC, Nicol GD. The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons:whole-cell and single-channel studies. J Neurosci 18:6081-6092,1998.
57.Lichtman AH, Martin BR. Spinal and supraspinal components of cannabinoid-induced antinociception. J. Pharmacol. Exp. Ther.1991;258:517-523.
58.Lichtman AH, Cook SA, Martin BR. Investigation of brain sites mediating cannabinoid-induced antinociception in rats:evidence supporting periaqueductal gray involvement. J Pharmacol Exp Ther.1996; 276:585-593.
59.Melanie R. Lalonde, Christine A.B Jollimore, Kelly Stevens, Steven Barnes, Melanie E.M. Kelly (2006). Cannabinoid receptor-mediated inhibition of calcium signaling in rat retinal ganglion cells. Molecular Vision 12:1160-6
60.Martin BR, Compton DR, Thomas BF, et al. Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs. Pharmacol Biochem Behav.1991; 40: 471-478
61.Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
62.Munro S, Thomas KL, Abu-Shaar M (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65.
63.Millns PJ, Chapman V, Kendall DA (2001). Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones. Br J Pharmacol 132:969-971.
64.Malan Jr TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F (2003) CB2 cannabinoid receptor agonists:pain relief without psychoactive effects? Curr Opin Pharmacol 3:62-67.
65.Mohapatra DP, Nau C. Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 2005;280:13424-13432.
66.Marshall IC, Owen DE, Cripps TV, Davis JB, McNulty S, Smart D. Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-trisphosphate-sensitive stores. Br JPharmacol 138:172-176,2003.
67.Mao J, Price DD, Lu J, Keniston L, Mayer DJ. Two distinctive antinociceptive systems in rats with pathological pain. Neurosci Lett.2000; 280:13-16
68.Mohapatra, D. P.& Nau, C. (2003) J. Biol. Chem.278,50080-50090.
69.Mechoulam R, Fride E, Di Marzo V (1998). Endocannabinoids. Eur J Pharmacol 359:1-18.
70.Mu J, Zhuang SY, Kirby MT, et al. Cannabinoid receptors differentially modulate potassium A and D currents in hippocampal neurons. J Pharmcol Exp Ther.1999; 291:893-902.
71. Martin WJ, Tsou K, Walker JM. Cannabinoid receptor mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla. Neurosci. Lett.1998; 242:33-36.
72. Martin WJ, Coffin PO, Attias E, et al. Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections. Brin Res.1999; 822:237-242.
73 Martin WJ, Lai NK, Patrick SL, et al. Antinociceptive actions of cannabinoids following intraventricular administration in rats. Brain Res.1993;629:300-304.
74.Nicholson RA, Liao C, Zheng J, et al. Sodium channel inhibition by anandemide and synthetic annabimimetics in brain. Brain Res.2003; 978(1-2):194-204.
75.Netzeband JG, Conroy SM, Parsons KL, Gruol DL (1999). Cannabinoids enhance NMDA-elicited Ca2t signals in cerebellar granule neurons in culture. J Neurosci 19: 8765-8777.
76.Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T. and Ueda, N. (2004) Molecular characterization of a phospholipase D generating anandamide and its congeners. Journal of Biological Chemistry 279,5298-5305.
77.PRICE, T.J., HELESIC, G., PARGHI, D., HARGREAVES, K.M.& FLORES, C.M. (2003). The neuronal distribution of cannabinoid receptor type one in the trigeminal ganglion of the rat. Neuroscience,120,155-162.
78.Price, T. J., Patwardhan, A. M., Akopian, A. N., Hargreaves, K. M.& Flores, C. M. (2004) Br. J. Pharmacol.141,1118-1130.
79.Patwardhan AM, Jeske NA, Price TJ, Gamper N, Akopian AN, Hargreaves KM (2006) The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci USA 103:11393-11398.
80.Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol 168: 1-51,2005.
81.PERTWEE, R.G.& ROSS, R.A. (2002). Cannabinoid receptors and their ligands. Prostagland. Leukotr. Essent. Fatty Acids,66,101-121.
82.PERTWEE, R.G. (2004). Novel pharmacological targets for cannabinoids. Curr. Neuropharmacol.,2,9-29.
83.Pertwee RG (2001). Cannabinoid receptors and pain. Prog Neurobiol 63:569-611.
84.Pacher, P. et al. (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol. Rev.58,389-462
85.Piomelli, D. (2003) The molecular logic of endocannabinoid signalling. Nature Reviews Neuroscience 4,873-884.
86.Premkumar LS, Ahern GP. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408:985-990,2000.
87.Pop E (1999). Cannabinoids endogenous ligands and synthetic analogs. Curr Opin Chem Biol 3:418-425.
88.Richardson JD, Kilo S, Hargreaves KM (1998) Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75:111-119.
89.Rice ASC, Farquhar-Smith WP, and Nagy Ⅰ (2002) Endocannabinoids and pain:spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukotrienes Essent Fatty Acids 66:243-256.
90.ROSS, R.A. (2003). Anandamide and vanilloid TRPV1 receptors. Br. J. Pharmacol.,140, 790-801.
91.Rhian M. Evans, Roderick H. Scott, Ruth A. Ross (2004). Multiple actions of anandamide on neonatal rat cultured sensory neurons. British Journal of Pharmacology 141,1223-1233
92.Riddall DR, Leach MJ, Garthwaite J. A novel drug binding site on voltage-gated sodium channels in rat brain. Mol Pharmacol 69:278-287,2006.
93.Sarfaraz S, Afaq F, Adhami VM, Mukhtar H (2005). Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 65:1635-1641.
94.Stella, N., Schweitzer, P. and Piomelli, D. (1997) A second endogenous cannabinoid that modulates long-term potentiation. Nature 388,773-778.
95.Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999;51:159-212.
96.Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1:10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 2007;6:357-72.
97.Smart D, Jerman JC, Gunthorpe MJ, et al. Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology. Eur J Pharmacol 2001; 417:51-8
98.Starowicz K, Nigam S, Di Marzo V (2007). Biochemistry and pharmacology of endovanilloids. Pharmacol Ther 114:13-33.
99.Skaper SD, Buriani A, DalToso R, et al. The ALIAmid palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Nat Acad Sci.1996; 93:3984-3989.
100.Schweitzer P. Cannabinoids decrease the K(+) M-current in hippocampal CA1 neurons. JNeurosi.2000; 20:51-58.
101.Theodore J.Price, Amol Patwardhan, et al.. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. British Journal of Pharmacology (2004) 142,257-266
102.Tilo Fischbach, Wolfgang Greffrath, Hermann Nawrath, Rolf-Detlef Treede (2007). Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats. J Neurophysiol 98:929-938
103.Twitchell W, Brown S, Mackie K. Cannbinoids inhibit N-and P/O-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol.1997;78:43-50.
104.Vladimir V. Matchkov, Christian Aalkjaer, Holger Nilsson(2004). A Cyclic GMP-dependent Calcium-activated Chloride Current in Smooth-muscle Cells from Rat Mesenteric Resistance Arteries. J. Gen. Physiol.123,121-134
105.van der Stelt M, Di Marzo V. Endovanilloids:putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem 2004;271:1827-1834.
106.Walker JM, Hohmann G, Martin WJ, et al. The neurobiology of cannabinoid analgesia. Life Sci.1999;65:665-673.
107. Walker JM, Hohmann AG. Cannabinoid mechanisms of pain suppression. Handb Exp Pharmacol 168:509-554,2005.
108.Walker JM, Huang SM (2002). Cannabinoid analgesia. Pharmacol Ther 95:127-135
109.Zimmer, A. et al. (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc. Natl. Acad. Sci. U. S. A.96, 5780-5785
11O.ZYGMUNT, P.M., PETERSSON, J., ANDERSSON, D.A., CHUANG, H., SFRGA0 RD, M., DI MARZO, V., JULIUS, D.& HO" GESTA" TT, E.D. (1999). Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature,400, 452-457.
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