健康年青人含碳脂肪餐后血脂血糖变化及影响因素
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摘要
目的:探讨健康不同体重指数年青人(平均年龄18.81±1.6岁)脂肪餐后血脂变化及影响因素,并观察含碳与无碳脂肪餐对餐后甘油三酯(TG)和血糖(PG)影响的差别以及年青人与中年人餐后TG和PG的差别。
方法:(1)112例健康年青人(平均18.81±1.6岁)进食含碳脂肪餐(热量600kal,其中脂肪27g(42%),含碳水化合物为67g(50%),蛋白质为24g(18%))后测定空腹、餐后2、4、6小时血脂(TG)、血糖(PG),同时测量基础状态下体重、身高、血压、心率,计算体重指数(BMI)。根据BMI分为偏重、正常、偏轻。(2)选20名30-50岁健康成年人(中年)为对照,以观察年龄对餐后各时间段TG、PG的影响。(3)选择18-20岁的健康男性40名,随机进食含碳脂肪餐(同前)和无碳脂肪餐(热量600kal,其中脂肪36g(56%),蛋白质64g(44%)),观察含碳与无碳脂肪餐对餐后各时间段的TG和PG影响的差别。
结果:(1)健康年青人含碳脂肪餐后TG变化呈现由下降至恢复的变化趋势;PG呈现由升高至恢复的变化趋势;不同体重指数组之间TG、TG-AUC有显著性差异(P<0.05),三组曲线明显不同,BMI越高,空腹及餐后各时间点的TG越高(P<0.05)。(2)男性和女性基础TG无明显差异,但女性餐后TG下降更为明显。(3)不同体重指数的空腹及餐后各时点的血糖水平无显著性差异(p>0.05);体重指数与TG0、PG0呈正相关(TG0,r=0.317,p=0.001;PG0, r =0.247,p=0.009)。(4)中年组空腹TG稍高,含碳脂肪负荷餐后3个时间点TG水平增高,而青年组呈下降趋势,反应曲线明显不同。TG2、TG4、TG6以及TG-AUC均明显高于青年组。(5)含碳脂肪餐组餐后2h、4h的TG下降,6h仍低于空腹水平;无碳脂肪餐组2h的TG上升,4h达高峰,6h有所下降,曲线特点完全不同。
结论:(1)健康年青人含碳脂肪餐后TG变化呈现由下降至恢复的变化趋势;(2)健康年青人含碳脂肪餐后BMI越高,空腹及餐后TG越高,BMI偏重者,存在餐后脂代谢紊乱的可能;(3)年龄、性别是影响脂肪负荷餐后TG代谢的重要因素;(4)含碳脂肪餐与无碳脂肪餐对餐后TG的影响不同,含碳脂肪餐可导致健康年青人餐后TG水平下降,无碳脂肪餐易致健康年青人餐后水平升高,TG清除减慢。
Objective: To investigate the lipid changes and influencing factors after carbonaceous fatty meal of different weight index of healthy young (average age:18.81±1.6), and to observe the differences of the effect after different fatty meal postprandial TG and PG and the differences of postprandial TG and PG between young people and middle-aged .
Methods: (1) 112 healthy young people(average age:18.81±1.6) ate carbonaceous fatty meal(600kal heat, in which 27g fat (42%), 67g carbohydrates (50%), 24g protein (18%)) then measured fasting and postprandial TG and PG after 2, 4 and 6 hours. and made simultaneous measurement of fasting weight, height, blood pressure, heart rate and body mass index (BMI) at Basic condition. According to BMI, we divided three groups of specific criteria into overweight , normal, partial light.(2) Select 20 30-50 year old healthy adults (aged) to observe the effect of their age on postprandial TG, PG of different fatty meal. (3) 40 18-20 year healthy young people(young) ate carbonaceous fatty meal (the same before) and No carbon fatty meal(600kal heat, in which 36g fat (56%), 64g protein (44%) at random to observe the effect of on postprandial TG, PG of different fatty meal.
Results: (1) The postprandial TG change of carbonaceous fatty meal of Healthy young people showed the trend from decline to recovery.PG presents increasing trend to recovery; there are significantly differences (P <0.05) of TG, TG-AUC among different weight index. Three curves are quite different, the higher BMI is, the fasting and postprandial TG at all time points is higher (P <0.05))(2)Men and women have no significant differences on TG, but the postprandial TG decline of female are more marked.(3)There are no significant difference on fasting and postprandial glucose at each time point.(p>0.05)weight index and TG0, PG0 show positive correlation. (TG0,r=0.317,p=0.001;PG0, r =0.247,p=0.009)(4)fasting plasma TG of middle-aged is slightly higher, fat load of postprandial TG increases at 3 time points after carbonaceous fatty meal, while the young group decreasing, the reaction curves are quite different.TG2、TG4、TG6 and TG-AUC are all significant higher than the young group.
(5)2h, 4h of TG decrease after Carbonaceous fatty meal, 6h still below the fasting level; TG of fat fatty meal 2h increase, 4h gets peak, 6h declines and the curve characteristics are totally different.
Conclusions: (1) The postprandial TG change of carbonaceous fatty meal of Healthy young people showed the trend from decline to recovery.PG presents increasing trend to recovery.(2) The BMI of healthy young people after carbonaceous fatty meal is higher, the TG after fasting and postprandial index is greater, overweight people of BMI have the possiblity of postprandial lipid metabolism disorder.(3)Age and sex are the main influencing factors to TG.(4)The effect of Carbonaceous fatty meal and No carbon fatty meal on postprandial TG is different. carbonaceous fatty meal can lead to postprandial TG levels healthy young decreases, postprandial levels of No carbon fatty meal of healthy young people increased, TG clearance speed is slow.
方法:(1)112例健康年青人(平均18.81±1.6岁)进食含碳脂肪餐(热量600kal,其中脂肪27g(42%),含碳水化合物为67g(50%),蛋白质为24g(18%))后测定空腹、餐后2、4、6小时血脂(TG)、血糖(PG),同时测量基础状态下体重、身高、血压、心率,计算体重指数(BMI)。根据BMI分为偏重、正常、偏轻。(2)选20名30-50岁健康成年人(中年)为对照,以观察年龄对餐后各时间段TG、PG的影响。(3)选择18-20岁的健康男性40名,随机进食含碳脂肪餐(同前)和无碳脂肪餐(热量600kal,其中脂肪36g(56%),蛋白质64g(44%)),观察含碳与无碳脂肪餐对餐后各时间段的TG和PG影响的差别。
结果:(1)健康年青人含碳脂肪餐后TG变化呈现由下降至恢复的变化趋势;PG呈现由升高至恢复的变化趋势;不同体重指数组之间TG、TG-AUC有显著性差异(P<0.05),三组曲线明显不同,BMI越高,空腹及餐后各时间点的TG越高(P<0.05)。(2)男性和女性基础TG无明显差异,但女性餐后TG下降更为明显。(3)不同体重指数的空腹及餐后各时点的血糖水平无显著性差异(p>0.05);体重指数与TG0、PG0呈正相关(TG0,r=0.317,p=0.001;PG0, r =0.247,p=0.009)。(4)中年组空腹TG稍高,含碳脂肪负荷餐后3个时间点TG水平增高,而青年组呈下降趋势,反应曲线明显不同。TG2、TG4、TG6以及TG-AUC均明显高于青年组。(5)含碳脂肪餐组餐后2h、4h的TG下降,6h仍低于空腹水平;无碳脂肪餐组2h的TG上升,4h达高峰,6h有所下降,曲线特点完全不同。
结论:(1)健康年青人含碳脂肪餐后TG变化呈现由下降至恢复的变化趋势;(2)健康年青人含碳脂肪餐后BMI越高,空腹及餐后TG越高,BMI偏重者,存在餐后脂代谢紊乱的可能;(3)年龄、性别是影响脂肪负荷餐后TG代谢的重要因素;(4)含碳脂肪餐与无碳脂肪餐对餐后TG的影响不同,含碳脂肪餐可导致健康年青人餐后TG水平下降,无碳脂肪餐易致健康年青人餐后水平升高,TG清除减慢。
Objective: To investigate the lipid changes and influencing factors after carbonaceous fatty meal of different weight index of healthy young (average age:18.81±1.6), and to observe the differences of the effect after different fatty meal postprandial TG and PG and the differences of postprandial TG and PG between young people and middle-aged .
Methods: (1) 112 healthy young people(average age:18.81±1.6) ate carbonaceous fatty meal(600kal heat, in which 27g fat (42%), 67g carbohydrates (50%), 24g protein (18%)) then measured fasting and postprandial TG and PG after 2, 4 and 6 hours. and made simultaneous measurement of fasting weight, height, blood pressure, heart rate and body mass index (BMI) at Basic condition. According to BMI, we divided three groups of specific criteria into overweight , normal, partial light.(2) Select 20 30-50 year old healthy adults (aged) to observe the effect of their age on postprandial TG, PG of different fatty meal. (3) 40 18-20 year healthy young people(young) ate carbonaceous fatty meal (the same before) and No carbon fatty meal(600kal heat, in which 36g fat (56%), 64g protein (44%) at random to observe the effect of on postprandial TG, PG of different fatty meal.
Results: (1) The postprandial TG change of carbonaceous fatty meal of Healthy young people showed the trend from decline to recovery.PG presents increasing trend to recovery; there are significantly differences (P <0.05) of TG, TG-AUC among different weight index. Three curves are quite different, the higher BMI is, the fasting and postprandial TG at all time points is higher (P <0.05))(2)Men and women have no significant differences on TG, but the postprandial TG decline of female are more marked.(3)There are no significant difference on fasting and postprandial glucose at each time point.(p>0.05)weight index and TG0, PG0 show positive correlation. (TG0,r=0.317,p=0.001;PG0, r =0.247,p=0.009)(4)fasting plasma TG of middle-aged is slightly higher, fat load of postprandial TG increases at 3 time points after carbonaceous fatty meal, while the young group decreasing, the reaction curves are quite different.TG2、TG4、TG6 and TG-AUC are all significant higher than the young group.
(5)2h, 4h of TG decrease after Carbonaceous fatty meal, 6h still below the fasting level; TG of fat fatty meal 2h increase, 4h gets peak, 6h declines and the curve characteristics are totally different.
Conclusions: (1) The postprandial TG change of carbonaceous fatty meal of Healthy young people showed the trend from decline to recovery.PG presents increasing trend to recovery.(2) The BMI of healthy young people after carbonaceous fatty meal is higher, the TG after fasting and postprandial index is greater, overweight people of BMI have the possiblity of postprandial lipid metabolism disorder.(3)Age and sex are the main influencing factors to TG.(4)The effect of Carbonaceous fatty meal and No carbon fatty meal on postprandial TG is different. carbonaceous fatty meal can lead to postprandial TG levels healthy young decreases, postprandial levels of No carbon fatty meal of healthy young people increased, TG clearance speed is slow.
引文
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