应变率成像评价高血压患者左心房功能
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摘要
目的：应用应变率成像(SRI)技术比较不同左心室构型原发性高血压患者左心房应变(S)及应变率(SR),分析SR与左心房功能传统超声参数的相关性,探讨SRI评价原发性高血压患者左心房功能的临床价值。
方法：原发性高血压患者160例,分为左室正常构型(LVN)组40例、左室向心性重构(CR)组40例、左室向心性肥厚(CH)组40例、左室离心性肥厚(EH)组40例；正常人41例为对照组。(1)于心尖二腔、三腔及四腔切面,应用SRI技术分别获取左心房前壁、下壁、后壁、侧壁及房间隔中段S及SR曲线,测量左室收缩期左心房峰值应变率(SRs)、左室舒张早期左心房峰值应变率(SRe)、左室舒张晚期左心房峰值应变率(SRa)及左心房最大S值。(2)于心尖四腔切面,应用组织多普勒(TDI)获得二尖瓣环附着处TDI频谱,测量二尖瓣环左室舒张早期峰值速率(E’)和左室舒张晚期峰值速率(A’),计算E'/A’；应用脉冲多普勒获得二尖瓣口血流频谱,测量左室舒张早期血流峰值速率(E)和左室舒张晚期血流峰值速率(A),计算E/A。(3)于心尖四腔切面,应用单平面simpson法测量左心房最大容积(LAVmax)、左心房最小容积(LAVmin)及左心房收缩前容积(LAVpre),计算左心房主动射血分数(LAAEF)、左心房被动射血分数(LAPEF)；于胸骨旁左室长轴切面测量左室收缩末期左心房前后径(LAD)、左室舒张末期左心室前后径(LVDd)、左心室后壁厚度(LVPWd)及室间隔厚度(IVSd)。
结果：(1)与对照组比较,高血压各组SRe及SRs均显著减低,LVN组、CR组及CH组SRa均显著增高,EH组SRa显著减低(P<0.05)。(2)LAAEF在以下四组组间呈递增趋势,对照组0.05),余组间差异均有统计学意义(p<0.05)。(3)SRa与LAAEF相关性良好(r=0.735,P<0.01)；SRe与LAPEF相关性良好(r=0.597,P<0.01)。(4)E/A在对照组与LVN组间无显著差异(P>0.05),CR组、CH组及EH组分别与对照组及LVN组比较显著减低(P<0.05),CR组、CH组及EH组之间比较无显著差异(p>0.05)。高血压各组与对照组比较E'/A'均显著减低(p<0.01),CR组、CH组及EH组之间比较E'/A’无显著差异(p>0.05)。(5)对照组左心房各壁SR及S均显著大于房间隔(P<0.05)。
结论：(1)SRa、SRe、SRs能够评价高血压患者左心房收缩及舒张功能。(2)左心房SR指标在左心室发生重构前就能够反映高血压患者左心房功能改变；随着高血压的病程进展,左心房储蓄及管道功能逐步减弱,辅泵功能逐步增强；当左心室发生离心性肥厚时,左心房辅泵功能亦减弱。(3)左心房SRa及SRe在高血压早期能够敏感地反映左心室舒张功能变化。(4)左心房各壁与房间隔比较SR及S有显著差异,左心房各壁形变程度均大于房间隔。
Objective:To compare strain and strain rate in primary hypertensive patients with different configuration of left ventricular(LV) by Strian Rate Imaging(SRI), analysis the dependability of strain rate and traditional ultrasound parameter, and approach the clinical value of evaluating left atrial(LA) function by SRI.
Methods:160 patients with primary hypertensions were divided into normal pattern LV (LVN,n=40) and concentric remodeling pattern LV (CR,n=40),concentric hypertrophy LV(CH,n=40),eccentric hypertrophy LV(EH,n=40),and 41 healthy participants were also included.(1)At three-chamber and four-chamber view,the strain and the strain rate curves was gained in the middle segments of each left atrial wall(left atrial anterior wall,inferior Wall,posterior wall,lateral wall and Atrial Septum) by SRI. Strain rate parameters SRs were measured during left ventrial systolic phase,SRe were measured during left ventrial diastolic early phase,SRa were measured during left ventrial diastolic later phase and max strain were measured. (2)At four-chamber view,Peak velocity during left ventrial diastolic early phase(E') and Peak velocity during left ventrial diastolic later phase (A') of each mitral annulus were measured on Tissure Doppler imaging(TDI) and then E'/A' were calculate. Peak velocity during left ventrial diastolic early phase (E) and Peak velocity during left ventrial diastolic later phase (A) of mitralis bloodstream spectra were measured on pulsed wave Doppler(PW) imaging,then E/A were calculate. (3) At four-chamber view, left atrail maximum volurne(LAVmax), left atrail minimum volume(LAVmin) and left atrial preliminary systole Volurne(LAVpre) were measured by single plane simpson way, and left atrail active ejection fraction(LAAEF) and passive ejection fraction (LAPEF) were calculated; At LV long axis view, left atrail maximum internal diameter(LAD),LV maximum internal diameter(LVDd),thickness of LV posterior wall(LVPWd) and ventricularl Septum(IVSd) were measured during LV end-diastole.
Results:(1)Compared with the control group,the SRs and SRe were reduced in hypertensive group,meanwhile the SRa were higher in LVN group,CR group and CH group,and the SRa were reduced in EH group(p<0.05). (2) LAAEF increased by degree in the four group, Nomal groupLVN group>CR group>CH group>EH group (p<0.05).(3)The dependability of SRa and LAAEF was closely(r=0.735,P<0.01),SRe and LAPEF was closely too(r=0.579,p<0.01).(4) Compared with the control group,E'/A' were reduced in hypertensive group, E/A were reduced in CR group,CH group and EH group,but E/A were not reduced in LVN;LAD,LAVmax,LAVmin,LAVpre,LAAEF and LAPEF was higher in hypertensive group(p<0.05). (5)SR of LA with health adult walls were higher than atrial septum(p<0.05).
Conclusions:(1)The SRa、SRe and SRs can acess LA function. (2)The SR parameter can reflect the change of LA function before LV reconstitute;Following development of hypertension,LA saving and tuding function were weakened,pumping function was reinforced gradually, and LA pumping function was weakened during hypertensive later period.(3)SRa and SRe of LA can assess the change of LV diastolic function sensitively during hypertensive earlier period. (4) The eformation of LA walls were higher than atrial septum.
方法：原发性高血压患者160例,分为左室正常构型(LVN)组40例、左室向心性重构(CR)组40例、左室向心性肥厚(CH)组40例、左室离心性肥厚(EH)组40例；正常人41例为对照组。(1)于心尖二腔、三腔及四腔切面,应用SRI技术分别获取左心房前壁、下壁、后壁、侧壁及房间隔中段S及SR曲线,测量左室收缩期左心房峰值应变率(SRs)、左室舒张早期左心房峰值应变率(SRe)、左室舒张晚期左心房峰值应变率(SRa)及左心房最大S值。(2)于心尖四腔切面,应用组织多普勒(TDI)获得二尖瓣环附着处TDI频谱,测量二尖瓣环左室舒张早期峰值速率(E’)和左室舒张晚期峰值速率(A’),计算E'/A’；应用脉冲多普勒获得二尖瓣口血流频谱,测量左室舒张早期血流峰值速率(E)和左室舒张晚期血流峰值速率(A),计算E/A。(3)于心尖四腔切面,应用单平面simpson法测量左心房最大容积(LAVmax)、左心房最小容积(LAVmin)及左心房收缩前容积(LAVpre),计算左心房主动射血分数(LAAEF)、左心房被动射血分数(LAPEF)；于胸骨旁左室长轴切面测量左室收缩末期左心房前后径(LAD)、左室舒张末期左心室前后径(LVDd)、左心室后壁厚度(LVPWd)及室间隔厚度(IVSd)。
结果：(1)与对照组比较,高血压各组SRe及SRs均显著减低,LVN组、CR组及CH组SRa均显著增高,EH组SRa显著减低(P<0.05)。(2)LAAEF在以下四组组间呈递增趋势,对照组
结论：(1)SRa、SRe、SRs能够评价高血压患者左心房收缩及舒张功能。(2)左心房SR指标在左心室发生重构前就能够反映高血压患者左心房功能改变；随着高血压的病程进展,左心房储蓄及管道功能逐步减弱,辅泵功能逐步增强；当左心室发生离心性肥厚时,左心房辅泵功能亦减弱。(3)左心房SRa及SRe在高血压早期能够敏感地反映左心室舒张功能变化。(4)左心房各壁与房间隔比较SR及S有显著差异,左心房各壁形变程度均大于房间隔。
Objective:To compare strain and strain rate in primary hypertensive patients with different configuration of left ventricular(LV) by Strian Rate Imaging(SRI), analysis the dependability of strain rate and traditional ultrasound parameter, and approach the clinical value of evaluating left atrial(LA) function by SRI.
Methods:160 patients with primary hypertensions were divided into normal pattern LV (LVN,n=40) and concentric remodeling pattern LV (CR,n=40),concentric hypertrophy LV(CH,n=40),eccentric hypertrophy LV(EH,n=40),and 41 healthy participants were also included.(1)At three-chamber and four-chamber view,the strain and the strain rate curves was gained in the middle segments of each left atrial wall(left atrial anterior wall,inferior Wall,posterior wall,lateral wall and Atrial Septum) by SRI. Strain rate parameters SRs were measured during left ventrial systolic phase,SRe were measured during left ventrial diastolic early phase,SRa were measured during left ventrial diastolic later phase and max strain were measured. (2)At four-chamber view,Peak velocity during left ventrial diastolic early phase(E') and Peak velocity during left ventrial diastolic later phase (A') of each mitral annulus were measured on Tissure Doppler imaging(TDI) and then E'/A' were calculate. Peak velocity during left ventrial diastolic early phase (E) and Peak velocity during left ventrial diastolic later phase (A) of mitralis bloodstream spectra were measured on pulsed wave Doppler(PW) imaging,then E/A were calculate. (3) At four-chamber view, left atrail maximum volurne(LAVmax), left atrail minimum volume(LAVmin) and left atrial preliminary systole Volurne(LAVpre) were measured by single plane simpson way, and left atrail active ejection fraction(LAAEF) and passive ejection fraction (LAPEF) were calculated; At LV long axis view, left atrail maximum internal diameter(LAD),LV maximum internal diameter(LVDd),thickness of LV posterior wall(LVPWd) and ventricularl Septum(IVSd) were measured during LV end-diastole.
Results:(1)Compared with the control group,the SRs and SRe were reduced in hypertensive group,meanwhile the SRa were higher in LVN group,CR group and CH group,and the SRa were reduced in EH group(p<0.05). (2) LAAEF increased by degree in the four group, Nomal group
Conclusions:(1)The SRa、SRe and SRs can acess LA function. (2)The SR parameter can reflect the change of LA function before LV reconstitute;Following development of hypertension,LA saving and tuding function were weakened,pumping function was reinforced gradually, and LA pumping function was weakened during hypertensive later period.(3)SRa and SRe of LA can assess the change of LV diastolic function sensitively during hypertensive earlier period. (4) The eformation of LA walls were higher than atrial septum.
引文
[1]Miller JT,et al.Left atrial enlargement:an early sign of hypertension heart disease[J].Am Heart J,1988,116:1048-1053.
[2]De Boeck BW,Cramer MJ,Oh JK,et al:Spectral pulsed Doppler imagine in diastole:a tool to increase our in sight in and assessment of diastolic relaxation of the left ventricle[J].Am Heart J,2003,146:411-419.
[3]Sevimli S,Gundogdu F,Arslan S,et al.Strain and strain rate imagine in evaluating left atrial appendage function by transesophageal[J].Echocardiography, 2007,24(8):823-829.
[4]Tada T,Oki T,Abe M,et al.The role of short-and long-axis function in determining late diastolic left ventricular filling in patients with hypertention:assensment by pulsed Doppler tissue imaging[J].J Am Soc Echocardiagr,2002,15(10 Pt2): 1211-1217.
[5]叶彩宏,朱向明,李国杰,等.应变率超声成像定量评价高血压患者左室局部舒张功能.中国超声医学杂志,2009,(25)3：267-269.
[6]苏玲俐,郭瑞强,周青,等.应变率显像对高血压患者左室舒张功能的评价.中国医学影像技术,2005,20(9)：1392-1394.
[7]刘莉,郭瑞强,周青,等.应变率成像对不同左室构型高血压病患者左房收缩功能的研究[J].中国超声医学杂志,2007,23(6)：426-428.
[8]Inaba Y, Yuda S, Kobayashi N,et al. Strain rate imaging for noninvasive functional quantification of the left atrium:comparative studies in controls and patients with atrial fibrillation[J].J Am Soc Echocardiogr,2005,18(7):729-730.
[9]Ganau A,Devereux RB,Roman MJ,et al.Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension[J].J Am Coll Cardiol,1992,19(7):1150-1158.
[10]Foppa M,Duncan BB,Rohde L E, Echocardiography based left ventricular mass estimation.How should we define hypertrophy[J]?Cardiovascular Ultrasound,2005,17(3):17-30.
[11]Erol MK,Yilmaz M,Acikel M,et al.Left atrial mechanical function in patients with essential hypertension [J]. Acta Cardiol,2002,57(5):323-327.
[12]Dhooge J,Heimdal A,Jamal F,et al.Regional strain and strain rate measurements by cardial ultrasound:principles,implementation and limitations[J].Eur J Echocardiography,2000,1 (1):154-170.
[13]Baur LH.Strain and strain rate imaging:a promising tool for evaluation of ventricular function[J].Int J Cardiovascular Imaging,2008,24 (5):493-494.
[14]Yip G,Abraham T,Belohlavek M,et al.Clinical applications of strain rate imaging [J].J Am Soc Echocardiogr,2003,16(12):1334-1342.
[15]Marwick TH.Measurement of strain and strain rate by echocardiography:ready for prime time? [J].J Am Coll Cardiol,2006,47(7):1313-1327.
[16]D'Andren A,De Corato G,Scarafile R,et al.Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy:a two-dimensional speckle strain study[J].Br J Sports Med,2008,42(8):696-702.
[17]Leung DY,Boyd A,Ng AA,et al.Echocardiographic evaluation of left atrial size and function:current understanding,pathophysiologic correlates,and prognostic implications[J].Am Heart J,2008,156 (6):1056-1064.
[18]D'Andrea A,De Corato G,Scarafile R,et al.Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy:a tow-dimensional speckle strain study[J].Br J Sports Med,2008,42(8):696-702.
[19]Jamal F,Strotmann J,Weidemann F,et al.Noninvasive quantification of the contractile reserve of stunned myocardium by ultra-sonic strain rate and strain [J].Circulation,2001,104(9):1059-1065.
[20]Weidemann F,Dommke C,Bijnens B,et al.Defining the transmurality of a chronic myocardial infarction by ultrasonic strain-rateimaging:implications for identifying intramural viability:an exterimental study[J]. Circulation,2003,107 (6):883-888.
[21]Wang Z,Tan H,Zhong M,et al.Strain rate imagine for noninvasive functional quantification of the left atrium in hypertensive patients with paroxysmal atrial fibrillation[J].Cardiology,2008,109(1):15-24.
[22]Jnaba Y,Yuda S,Kobayashi N,et al.Strain rate imaging for noninvasive functional quantification of the left atrium:Comparative study in controls and patients with atrial fibrillation[J].J Am Soc Echocardiogr,2005,18(7):729-736.
[23]Hoit BD.Left atrial function in health and disease[J].Eur Heart J,2000,2 (Suppl K):K9-K16.
[24]Hoit BD.Assessing atrial mechanical remodeling and its consequences[J]. Circulation,2005,112(3):304.
[25]温朝辉,吴长君,温朝阳.等超声心动图快速评价高血压心脏病左心房收缩功能[J].中国医学影像技术.2005,21(5)：718-720.
[26]Schneider C,Malisius R,Krause K,et al.Strain rate imaging for functional quantification of the left atrium:atrial deformation predicts the maintenance of sinus rhythm after eatheter ablation of atrial fibrillation[J]. Eur Heart J,2008,29 (11):1397-1409.
[27]Nikitin NP,Witti KK,Thackray SD,et al.Effect of age and sex on left atrial morphology and function[J].Eur J Echocardiogr,2003,4(1):36-42.
[28]Tsang TS,Barnes ME.Bailey KR,et al.Left atrial volume:important risk marker of incident atrial fibrillation in 1655 older men and women.Mayo Clin Proc,2001,76(5):467-475.
[29]Gilman G,Khandheria BK, Hagen ME,et al.Strain rate and strain:a step-by-step approach to image and data acquisition[J].J Am Soc Echocardiogr,2004,17(9): 1011-1020.
[30]Oguzhan A,Arinc H,Abaci A,et al.Preload dependence of Doppler tissue imaging derived indexes of left ventricular diastolic function[J].Echocardiography,2005, 22(4):320-325.
[31]Donal E,Raud Raynier P,Racaud A,et al.Quantitative regional analysis of left atrial function by Doppler tissue imaging-derived parameters discriminates patients with posterior and anterior myocardial infarction[J].J Am Soc Echocardiogr,2005,18(1):32-38.
[32]Alam M,Wardell J,Andersson E,et al.Assessment of left ventricular function using mitral annular velocities in patients with congestive heart failure with or without the presence of significant mitral regurgitation[J].J Am Soc Echocardiogr,2003,16(3):240-245.
[33]李利,张军,周晓东,等.房间隔应变率成像鉴别左室舒张功能假性正常表现[J].中国医学影响技术,2006,22(5)：695-697.
[34]Farias CA,Rodriguez L,Garcia MJ,et al.Assessment of diastolic function by tissue Doppler echocardiography:comparison with standard transmitral and pulmonary venous flow[J].J Am Soc Echocardiography,1999,12:609-617.
[35]Bowman AW,Kovacs SJ.Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart:a combined MRI-echocardiographic study[J].Am J Physiol Heart Circ Physiol,2004,286 (6):H2416-2424.
[36]Grossmna W.Diastolic dysfunction and heart failure:an overview[J].Eur Heart J,1990,11(Suppl):2-7.
[37]Masugata H,Mizushige K,Senda S,et al.Evaluation of left atrial wall elasticity using acoustic microscopy[J].Angiology,1999,50(7):583-590.
[38]Hoit BD,Shao Y,Tsai LM,et al.Altered left atrial compliance after atrial and ventricular filling[J].Cire Res,1993,72(1):167-175.
[39]夏娟,郭瑞强,陈金玲等.二维斑点追踪显像技术评价高血压病患者左房功能[J].中国超声医学杂志,2009,25(9)：866-868.
[40]Sirbu C,Herbots L,D'booge J,et al.Feasibility of strain and strain rate imagine for the assessment of regional left atrial deformation:a study in normal subjects [J].Eur J Echocardiography,2006,7(3):199-208.
[41]Dandel M,Hetzer R.Echocardiographic strain and strain rate imaging—clinical applications[J].Int J Cardiol,2009,132(1):11-24.
[1]Khankirawatana B,Khankirawatana S,Peterson B,et al.Peak atrial systolic mitral annular velocity by Doppler tissue reliably predicts left atrial systolic function[J].J Am Soc Echocardiogr,2004,17(4):353-360.
[2]Nagueh SF,Middleton KJ,Kopelen HA,et al.Doppler tissue imaging:a noninvasive technique for left ventricular relaxation and estimation of filling pressures[J].J Am Coll Cardiol,1997,30(6):1527-1533.
[3]Adebivi AA,A je A,Oqah OS,et al.Correlates of left atrial size in Nigerian hypertensives[J]. Cardiovasc,J S A fr,2005,16 (3):158-161.
[4]Di Tullio MR,Sacco RL,Sciacca RR,et al.Left atrial size and the risk of ischemic stroke in an ethnically mixed population[J].Stroke,1999,30:2019-2024.
[5]Wang T,Massaro JM,Levy D,et al.Arisk score for predicting stroke or death in individual swith new-onset atrial fibrillation in the community:the Framingham heart study[J].JAMA,2003,290(8):1049-1056.
[6]Gerdts E,Oikarien L,Palmier V,et al.Correlates of left atrial size in hypertensive patients with left ventricular hypertrophy[J]..Hypertension,2002,39(3):739-743.
[7]Benjamin EJ,D'Agostino RB,Belanger AJ,et al.Left atrial size and the risk of stroke and death:the framingham heart study[J].Circulation,1995,92 (4):835-841.
[8]Di Tullio MR,Sacco RL,Sciacca RR,et al.Left atrial size and the risk of schemic in an ethnically mixed population [J].Stroke,1999,30 (10):2019-2024.
[9]Miller JT,et al.Left atrial enlargement:an early sign of hypertension heart disease[J].Am Heart J,1988,l 16:1048-1053.
[10]陈晓峰,穆玉明,唐琪,等.应用组织速度和应变率成像技术对比研究急性心肌缺血时左室压力变化对左房功能的影响[J].中国医学影像技术,2008,24(2)：180-184.
[11]张爱宏,段学蕴,曹铁生主编.现代实用超声诊断学[J].北京：中国医药科技出版社,2006.5：398.
[12]Ganau A,Devereux RB,Roman MJ,et al.Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension[J].J Am Coll Cardiol, 992,19(7):1150-1158.
[13]Leung DY,Boyd A,Ng AA,et al.Echocardiographic evaluation of left atrial size and function:current understanding,pathophysiologic correlates,and prognostic implications[J].Am Heart J,2008,156 (6):1056-1064.
[14]王志浩,张薇,谭红伟,等.高血压病合并频发室性期前收缩患者左心房局部功 能的应及应变率评价[J].中华超声影像学杂志,2007,16(3)：198.
[15]温朝辉,吴长君,温朝阳,等.超声心动图快速评价高血压心脏病左心房收缩功能[J].中医学影像技术,2005,21(5)：718.
[16]刘莉,郭瑞强,周青,等.应变率成像对不同左室构型高血压患者左房收缩功能的研究[J].中国超声医学杂志,2007,23(6)：426-428.
[17]胡佳琪,郭瑞强,周青,等.应变率评价不同左室构型高血压患者心脏功能[J].中国医学影像技术,2005,21(7)：1022-1024.
[18]Kurt M,Wang JW.Left atrial function in diastolic heart failure guillermo[J]. Circulation:Cardiovascular Imaging,2009,2(1):10-15.
[19]Appleton CP,Kovacs SJ.The role of left atrial function in diastolic heart failure[J].Circulation:Cardiovascular Imaging,2009,2(1):6-9.
[20]Nikitin NP,Witte KK,Thackray SD,et al.Effect of age and sex on left atrial morphology and function[J]. Eur J Echocardiography,2003,4 (1):36-42.
[21]Simek CL,FeldmanMD,Haber HL,et al.Relationship between left ventricular wall thickness and left atrial size:comparison with other measures of diastolic function[J]. J Am Soc Echocardiogr,1995,8(1):37-42.
[22]Cuspidi C,Meani S, Fusi V,et al. Prevalence and correlates of left atrial enlargement in essential hypertension:role of ventricular geometry and the metabolic syndrome:the evaluation of target organ damage in hypertension study[J]. J Hypertens,2005,23(4):875-882.
[23]Manning WJ,Silverman DI,Katz SE,et al.Atrial ejection force:a noninvasive assessment of atrial systolic function[J]. J Am Coll Cardiol,1987,22:221-225.
[24]Matsuda Y,Toma Y,Moritanik K,et al.Assessment of left atrial function in patients with hypertension heart disease[J]. Hypertension,1987,8:779-785.
[25]王岳恒,王玉芳,张继增,等.超声心动图对高血压病左房功能的研究[J].中华物理医学杂志,1993,15(3)：163-166.
[26]Hoit BD.Left atrial function in health and disease[J].Eur Heart J,2000,2(Suppl-K):K9-K16.
[27]王岳恒,王建华,韩若凌.高血压病患者左心房射血力改变及其影响因素分析[J].中华超声影像学杂志,2003,12(3)：146-148.
[28]Gaasch WH,Levine HJ,Quinones MA,et al.Left ventricular compliance: mechanisms and clinical implications[J].Am J Cardiol,1976,38:645-654.
[29]Lakatta EG,Mitchell JH Ch,Pomerance A,et al.Human aging:changes in structure and function[J].J Am Coll ardiol,1987,10:42A-47A.
[30]Thomas L,Levett K,Boyd A, et al.Changes in regional left atrial function with a ging:evaluation by Doppler tissue imaging[J].Eur J Echocardiogr,2003,4(2): 92-100.
[31]Manning WJ,Shannon RP,Santinga JA,et al.Reversal of changs in left ventricular diastolic filling associated with normal aging using dilitiazem[J]. Am J Cardiol,1991,67(9):894-896.
[32]Dhooge J,Heimdal A,Jamal F,et al.Regional strain and strain rate Measurements by cordial ultrasound:principles,implementation and limitations[J].Eur J Echo cardiography,2000,1 (1):154-170.
[33]Heimdal A,Stoylen A,Torp H,et al.Real-time strain rate imaging of the left ventricle by ultrasound[J]J Am SocEchocardiogr,1998,11(11):1013-1019.
[34]Marwick TH.Measurement of strain and strain rate by echocardiography:ready for prime time?[J] J Am Coll Cardiol,2006,47(7):1313-1327.
[35]Baur LH.Strain and strain rate imaging:a promising tool for evaluation of ventricular function[J].Int J Cardiovasc Imaging,2008,24 (5):493-494.
[36]Inaba Y, Yuda S, Kobayashi N,et al. Strain rate imaging for noninvasive functional quantification of the left atrium:comparative studies in controls and patients with atrial fibrillation[J].J Am Soc Echocardiogr,2005,18(7):729-730.
[37]Sirbu C,Herbots L,D'hooge J,et al.Feasibility of strain and strain rate imaging for the assessment of regional left atrial deformation:a study in normal subjects[J].Eur J Echocardiography,2006,7(3):199-208.
[38]Di Tullio MR,Sacco RL,Sciacca RR,et al.Left atrial size and the risk of ischemic stroke in an ethnically mixed population[J].Stroke,1999,30:2019-2024.
[39]李劫,王建华,杜丽娟,等.应变率成像对高血压病患者左心房功能的初步研究[J].中华医学超声杂志(电子版)2008,(5)4：625-631.
[40]Spencer KT, Mor-Avi V, Gorcsan J Ⅲ, et al. Effects of aging on left atrial reservoir, conduit, and booster pump function:amulti-institution acoustic quantification study[J]. Heart,2001,85(3):272-277.
[41]Weidemann F, Jamal F, Sutherland GR, et al. Myocardial function defined by strain rate and strain during alterations in inotropic states and heart rate[J]. Am J Physiol Heart Circ Physiol,2002,283(2):792-799.
[42]周亚静,王建华,杜丽娟.应变率成像评价不同构型高血压病患者左房功能[J].中国医学影像技术,2008,24(4)：538-540.
[43]黄国庆,李国杰,高枫等.应变率成像技术及彩色多普勒血流成像技术对原发性高血压病左房功能的定量评价[J].现代实用医学,2010,22(1)：87-88.
[44]张彦华,朱向明,方少兵.应变率成像技术定量评价高血压病左房功能的临床研究[J].实用医学杂志,2009,25(16)：2688-2690.
[45]邓燕,郭盛兰,马国添,等.应变率成像评估左心室不同舒张功能状态患者左心房功能[J].临床荟萃,2009,24(18)：1574-1577.
[46]金玲,龚渭冰,翟连会,等.应变率显像对原发性高血压患者心功能的评价[J].新乡医学院学报,2010,27(5)：481-483.
[47]Shi Y, Li D, Tardif JC, Nattel S. Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure [J]. Cardiovasc Res,2002,54:456-461.
[48]Healey JS, Baranchuk A, Crystal E, et al. Prevention of atrial fibrillation with angiotensin converting enzyme inhibitors and angiotensin receptor blockers:a meta-analysis [J]. J Am Coll Cardiol,2005,45:1832-1839.
[49]王彪,姚成立,刘霞.RAS抑制剂对高血压患者左心房功能的影响[J].宁夏医科大学学报.2009,31(3)：308-310.
[50]Tada T, Oki T, Abe M, et al. The role of short-axis and long-axis function in determining late diastolic left ventricular filling in patients with hypertension: assessment by pulsed Doppler tissue imaging [J].I Am Soc Echocardiogr, 2002,15(10 P:2):1211-1217.
[51]Yip G, Abraham T, Belohlavek M, et al. Clinical applications of strain rate imaging[J].I Am Soc Echocardiogr,2003,1612):1334-1342.
[52]Schneider C, Malisius R, Krause K, et al. Strain rate imaging for functional quantification of the left atrium:atrial deformation predicts the maintenance of sinus rhythm after eatheter ablation of atrial fibrillation [J].Eur Heart J, 2008,29(11):1397-1409.
[53]D'Andren A, De Corato G,Scarafile R,et al.Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy:a two-dimensional speckle strain study [J].Br J Sports Med,2008,42(8):696-702.
[54]肖小鹏,邓林云,汤冬梅.应变率成像技术定量评价原发性高血压患者左房功能的价值[J].江西医药,2009,44(3)：202-204.
[55]Dandel M, Hetzer R.Echocardiographic strain and strain rate imaging—clinical applications [J]. Int Cardiol,2009,132(1):11-24.
[56]Abraham TP,Belohlavek M,Thomson HL,et al.Time to onset of regional relaxa-tion:feasibility,variability and utility of a novel index of regional myocardial function by strain rate imaging [J].J Am Coll Cardiol,2002,39(9):1531.
[57]Langeland S,D'Hooge J,Wouters PF,et al.Experimental validation of a new ultrasound met hold for the simultaneous assessment of radial and longitudinal myocardial deformation independent of insonation angle[J]. Circulation, 2005,112(14):2157-2162.
[58]Leitman M,Lysyansky P,Sidenko S,et al.Two-dimension Strain anovel software for real-time quantitative echocardiograpic assessment of myocardial function [J]J Am Soc Echocardiogr,2004,17(10):1021-1029.
[59]Kim DG,Lee KJ, Lee S. Feasibility of two-dimensional global longitudinal strain and strain rate imaging for the assessment of left atrial function:a study in subjects with a low probability of cardiovascular disease and normal exercise capacity[J]. Echocardiography,2009,26 (10):1179-1187.
[60]杨颖,陈峰,齐丽彤,等.二维应变与组织多普勒评价心肌应变的对比研究[J].中国超声医学杂,2006,22(11)：834-836.
[61]Teske A J,De Boeck B W,Olimulder M,et al.Echocardiographic assessment of regional right ventricular function:a head-to-head comparison between 2-dimensional and tissue Doppler-derived strain analysis[J].J Am Soc Echo-cardiogr,2007,21(3):275-283.
[62]Korinek J,Kjaergaard J,Sengupta P P,et al.High spatial resolution speckle tracking improves accuracy of 2-dimensional strain measurements[J] J Am Soc Echocardiogr,2007,20(2):165-170.
[63]Vianna-Pinton R,Moreno CA,Baxter CM,et al.Two-dimensional speckle-tracking echocardiography of the left atrium feasibility and regional contraction and relaxation differences in normal subjects[J]. J Am Soc Echocardiogr,2009,22(3): 299-305.
[2]De Boeck BW,Cramer MJ,Oh JK,et al:Spectral pulsed Doppler imagine in diastole:a tool to increase our in sight in and assessment of diastolic relaxation of the left ventricle[J].Am Heart J,2003,146:411-419.
[3]Sevimli S,Gundogdu F,Arslan S,et al.Strain and strain rate imagine in evaluating left atrial appendage function by transesophageal[J].Echocardiography, 2007,24(8):823-829.
[4]Tada T,Oki T,Abe M,et al.The role of short-and long-axis function in determining late diastolic left ventricular filling in patients with hypertention:assensment by pulsed Doppler tissue imaging[J].J Am Soc Echocardiagr,2002,15(10 Pt2): 1211-1217.
[5]叶彩宏,朱向明,李国杰,等.应变率超声成像定量评价高血压患者左室局部舒张功能.中国超声医学杂志,2009,(25)3：267-269.
[6]苏玲俐,郭瑞强,周青,等.应变率显像对高血压患者左室舒张功能的评价.中国医学影像技术,2005,20(9)：1392-1394.
[7]刘莉,郭瑞强,周青,等.应变率成像对不同左室构型高血压病患者左房收缩功能的研究[J].中国超声医学杂志,2007,23(6)：426-428.
[8]Inaba Y, Yuda S, Kobayashi N,et al. Strain rate imaging for noninvasive functional quantification of the left atrium:comparative studies in controls and patients with atrial fibrillation[J].J Am Soc Echocardiogr,2005,18(7):729-730.
[9]Ganau A,Devereux RB,Roman MJ,et al.Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension[J].J Am Coll Cardiol,1992,19(7):1150-1158.
[10]Foppa M,Duncan BB,Rohde L E, Echocardiography based left ventricular mass estimation.How should we define hypertrophy[J]?Cardiovascular Ultrasound,2005,17(3):17-30.
[11]Erol MK,Yilmaz M,Acikel M,et al.Left atrial mechanical function in patients with essential hypertension [J]. Acta Cardiol,2002,57(5):323-327.
[12]Dhooge J,Heimdal A,Jamal F,et al.Regional strain and strain rate measurements by cardial ultrasound:principles,implementation and limitations[J].Eur J Echocardiography,2000,1 (1):154-170.
[13]Baur LH.Strain and strain rate imaging:a promising tool for evaluation of ventricular function[J].Int J Cardiovascular Imaging,2008,24 (5):493-494.
[14]Yip G,Abraham T,Belohlavek M,et al.Clinical applications of strain rate imaging [J].J Am Soc Echocardiogr,2003,16(12):1334-1342.
[15]Marwick TH.Measurement of strain and strain rate by echocardiography:ready for prime time? [J].J Am Coll Cardiol,2006,47(7):1313-1327.
[16]D'Andren A,De Corato G,Scarafile R,et al.Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy:a two-dimensional speckle strain study[J].Br J Sports Med,2008,42(8):696-702.
[17]Leung DY,Boyd A,Ng AA,et al.Echocardiographic evaluation of left atrial size and function:current understanding,pathophysiologic correlates,and prognostic implications[J].Am Heart J,2008,156 (6):1056-1064.
[18]D'Andrea A,De Corato G,Scarafile R,et al.Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy:a tow-dimensional speckle strain study[J].Br J Sports Med,2008,42(8):696-702.
[19]Jamal F,Strotmann J,Weidemann F,et al.Noninvasive quantification of the contractile reserve of stunned myocardium by ultra-sonic strain rate and strain [J].Circulation,2001,104(9):1059-1065.
[20]Weidemann F,Dommke C,Bijnens B,et al.Defining the transmurality of a chronic myocardial infarction by ultrasonic strain-rateimaging:implications for identifying intramural viability:an exterimental study[J]. Circulation,2003,107 (6):883-888.
[21]Wang Z,Tan H,Zhong M,et al.Strain rate imagine for noninvasive functional quantification of the left atrium in hypertensive patients with paroxysmal atrial fibrillation[J].Cardiology,2008,109(1):15-24.
[22]Jnaba Y,Yuda S,Kobayashi N,et al.Strain rate imaging for noninvasive functional quantification of the left atrium:Comparative study in controls and patients with atrial fibrillation[J].J Am Soc Echocardiogr,2005,18(7):729-736.
[23]Hoit BD.Left atrial function in health and disease[J].Eur Heart J,2000,2 (Suppl K):K9-K16.
[24]Hoit BD.Assessing atrial mechanical remodeling and its consequences[J]. Circulation,2005,112(3):304.
[25]温朝辉,吴长君,温朝阳.等超声心动图快速评价高血压心脏病左心房收缩功能[J].中国医学影像技术.2005,21(5)：718-720.
[26]Schneider C,Malisius R,Krause K,et al.Strain rate imaging for functional quantification of the left atrium:atrial deformation predicts the maintenance of sinus rhythm after eatheter ablation of atrial fibrillation[J]. Eur Heart J,2008,29 (11):1397-1409.
[27]Nikitin NP,Witti KK,Thackray SD,et al.Effect of age and sex on left atrial morphology and function[J].Eur J Echocardiogr,2003,4(1):36-42.
[28]Tsang TS,Barnes ME.Bailey KR,et al.Left atrial volume:important risk marker of incident atrial fibrillation in 1655 older men and women.Mayo Clin Proc,2001,76(5):467-475.
[29]Gilman G,Khandheria BK, Hagen ME,et al.Strain rate and strain:a step-by-step approach to image and data acquisition[J].J Am Soc Echocardiogr,2004,17(9): 1011-1020.
[30]Oguzhan A,Arinc H,Abaci A,et al.Preload dependence of Doppler tissue imaging derived indexes of left ventricular diastolic function[J].Echocardiography,2005, 22(4):320-325.
[31]Donal E,Raud Raynier P,Racaud A,et al.Quantitative regional analysis of left atrial function by Doppler tissue imaging-derived parameters discriminates patients with posterior and anterior myocardial infarction[J].J Am Soc Echocardiogr,2005,18(1):32-38.
[32]Alam M,Wardell J,Andersson E,et al.Assessment of left ventricular function using mitral annular velocities in patients with congestive heart failure with or without the presence of significant mitral regurgitation[J].J Am Soc Echocardiogr,2003,16(3):240-245.
[33]李利,张军,周晓东,等.房间隔应变率成像鉴别左室舒张功能假性正常表现[J].中国医学影响技术,2006,22(5)：695-697.
[34]Farias CA,Rodriguez L,Garcia MJ,et al.Assessment of diastolic function by tissue Doppler echocardiography:comparison with standard transmitral and pulmonary venous flow[J].J Am Soc Echocardiography,1999,12:609-617.
[35]Bowman AW,Kovacs SJ.Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart:a combined MRI-echocardiographic study[J].Am J Physiol Heart Circ Physiol,2004,286 (6):H2416-2424.
[36]Grossmna W.Diastolic dysfunction and heart failure:an overview[J].Eur Heart J,1990,11(Suppl):2-7.
[37]Masugata H,Mizushige K,Senda S,et al.Evaluation of left atrial wall elasticity using acoustic microscopy[J].Angiology,1999,50(7):583-590.
[38]Hoit BD,Shao Y,Tsai LM,et al.Altered left atrial compliance after atrial and ventricular filling[J].Cire Res,1993,72(1):167-175.
[39]夏娟,郭瑞强,陈金玲等.二维斑点追踪显像技术评价高血压病患者左房功能[J].中国超声医学杂志,2009,25(9)：866-868.
[40]Sirbu C,Herbots L,D'booge J,et al.Feasibility of strain and strain rate imagine for the assessment of regional left atrial deformation:a study in normal subjects [J].Eur J Echocardiography,2006,7(3):199-208.
[41]Dandel M,Hetzer R.Echocardiographic strain and strain rate imaging—clinical applications[J].Int J Cardiol,2009,132(1):11-24.
[1]Khankirawatana B,Khankirawatana S,Peterson B,et al.Peak atrial systolic mitral annular velocity by Doppler tissue reliably predicts left atrial systolic function[J].J Am Soc Echocardiogr,2004,17(4):353-360.
[2]Nagueh SF,Middleton KJ,Kopelen HA,et al.Doppler tissue imaging:a noninvasive technique for left ventricular relaxation and estimation of filling pressures[J].J Am Coll Cardiol,1997,30(6):1527-1533.
[3]Adebivi AA,A je A,Oqah OS,et al.Correlates of left atrial size in Nigerian hypertensives[J]. Cardiovasc,J S A fr,2005,16 (3):158-161.
[4]Di Tullio MR,Sacco RL,Sciacca RR,et al.Left atrial size and the risk of ischemic stroke in an ethnically mixed population[J].Stroke,1999,30:2019-2024.
[5]Wang T,Massaro JM,Levy D,et al.Arisk score for predicting stroke or death in individual swith new-onset atrial fibrillation in the community:the Framingham heart study[J].JAMA,2003,290(8):1049-1056.
[6]Gerdts E,Oikarien L,Palmier V,et al.Correlates of left atrial size in hypertensive patients with left ventricular hypertrophy[J]..Hypertension,2002,39(3):739-743.
[7]Benjamin EJ,D'Agostino RB,Belanger AJ,et al.Left atrial size and the risk of stroke and death:the framingham heart study[J].Circulation,1995,92 (4):835-841.
[8]Di Tullio MR,Sacco RL,Sciacca RR,et al.Left atrial size and the risk of schemic in an ethnically mixed population [J].Stroke,1999,30 (10):2019-2024.
[9]Miller JT,et al.Left atrial enlargement:an early sign of hypertension heart disease[J].Am Heart J,1988,l 16:1048-1053.
[10]陈晓峰,穆玉明,唐琪,等.应用组织速度和应变率成像技术对比研究急性心肌缺血时左室压力变化对左房功能的影响[J].中国医学影像技术,2008,24(2)：180-184.
[11]张爱宏,段学蕴,曹铁生主编.现代实用超声诊断学[J].北京：中国医药科技出版社,2006.5：398.
[12]Ganau A,Devereux RB,Roman MJ,et al.Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension[J].J Am Coll Cardiol, 992,19(7):1150-1158.
[13]Leung DY,Boyd A,Ng AA,et al.Echocardiographic evaluation of left atrial size and function:current understanding,pathophysiologic correlates,and prognostic implications[J].Am Heart J,2008,156 (6):1056-1064.
[14]王志浩,张薇,谭红伟,等.高血压病合并频发室性期前收缩患者左心房局部功 能的应及应变率评价[J].中华超声影像学杂志,2007,16(3)：198.
[15]温朝辉,吴长君,温朝阳,等.超声心动图快速评价高血压心脏病左心房收缩功能[J].中医学影像技术,2005,21(5)：718.
[16]刘莉,郭瑞强,周青,等.应变率成像对不同左室构型高血压患者左房收缩功能的研究[J].中国超声医学杂志,2007,23(6)：426-428.
[17]胡佳琪,郭瑞强,周青,等.应变率评价不同左室构型高血压患者心脏功能[J].中国医学影像技术,2005,21(7)：1022-1024.
[18]Kurt M,Wang JW.Left atrial function in diastolic heart failure guillermo[J]. Circulation:Cardiovascular Imaging,2009,2(1):10-15.
[19]Appleton CP,Kovacs SJ.The role of left atrial function in diastolic heart failure[J].Circulation:Cardiovascular Imaging,2009,2(1):6-9.
[20]Nikitin NP,Witte KK,Thackray SD,et al.Effect of age and sex on left atrial morphology and function[J]. Eur J Echocardiography,2003,4 (1):36-42.
[21]Simek CL,FeldmanMD,Haber HL,et al.Relationship between left ventricular wall thickness and left atrial size:comparison with other measures of diastolic function[J]. J Am Soc Echocardiogr,1995,8(1):37-42.
[22]Cuspidi C,Meani S, Fusi V,et al. Prevalence and correlates of left atrial enlargement in essential hypertension:role of ventricular geometry and the metabolic syndrome:the evaluation of target organ damage in hypertension study[J]. J Hypertens,2005,23(4):875-882.
[23]Manning WJ,Silverman DI,Katz SE,et al.Atrial ejection force:a noninvasive assessment of atrial systolic function[J]. J Am Coll Cardiol,1987,22:221-225.
[24]Matsuda Y,Toma Y,Moritanik K,et al.Assessment of left atrial function in patients with hypertension heart disease[J]. Hypertension,1987,8:779-785.
[25]王岳恒,王玉芳,张继增,等.超声心动图对高血压病左房功能的研究[J].中华物理医学杂志,1993,15(3)：163-166.
[26]Hoit BD.Left atrial function in health and disease[J].Eur Heart J,2000,2(Suppl-K):K9-K16.
[27]王岳恒,王建华,韩若凌.高血压病患者左心房射血力改变及其影响因素分析[J].中华超声影像学杂志,2003,12(3)：146-148.
[28]Gaasch WH,Levine HJ,Quinones MA,et al.Left ventricular compliance: mechanisms and clinical implications[J].Am J Cardiol,1976,38:645-654.
[29]Lakatta EG,Mitchell JH Ch,Pomerance A,et al.Human aging:changes in structure and function[J].J Am Coll ardiol,1987,10:42A-47A.
[30]Thomas L,Levett K,Boyd A, et al.Changes in regional left atrial function with a ging:evaluation by Doppler tissue imaging[J].Eur J Echocardiogr,2003,4(2): 92-100.
[31]Manning WJ,Shannon RP,Santinga JA,et al.Reversal of changs in left ventricular diastolic filling associated with normal aging using dilitiazem[J]. Am J Cardiol,1991,67(9):894-896.
[32]Dhooge J,Heimdal A,Jamal F,et al.Regional strain and strain rate Measurements by cordial ultrasound:principles,implementation and limitations[J].Eur J Echo cardiography,2000,1 (1):154-170.
[33]Heimdal A,Stoylen A,Torp H,et al.Real-time strain rate imaging of the left ventricle by ultrasound[J]J Am SocEchocardiogr,1998,11(11):1013-1019.
[34]Marwick TH.Measurement of strain and strain rate by echocardiography:ready for prime time?[J] J Am Coll Cardiol,2006,47(7):1313-1327.
[35]Baur LH.Strain and strain rate imaging:a promising tool for evaluation of ventricular function[J].Int J Cardiovasc Imaging,2008,24 (5):493-494.
[36]Inaba Y, Yuda S, Kobayashi N,et al. Strain rate imaging for noninvasive functional quantification of the left atrium:comparative studies in controls and patients with atrial fibrillation[J].J Am Soc Echocardiogr,2005,18(7):729-730.
[37]Sirbu C,Herbots L,D'hooge J,et al.Feasibility of strain and strain rate imaging for the assessment of regional left atrial deformation:a study in normal subjects[J].Eur J Echocardiography,2006,7(3):199-208.
[38]Di Tullio MR,Sacco RL,Sciacca RR,et al.Left atrial size and the risk of ischemic stroke in an ethnically mixed population[J].Stroke,1999,30:2019-2024.
[39]李劫,王建华,杜丽娟,等.应变率成像对高血压病患者左心房功能的初步研究[J].中华医学超声杂志(电子版)2008,(5)4：625-631.
[40]Spencer KT, Mor-Avi V, Gorcsan J Ⅲ, et al. Effects of aging on left atrial reservoir, conduit, and booster pump function:amulti-institution acoustic quantification study[J]. Heart,2001,85(3):272-277.
[41]Weidemann F, Jamal F, Sutherland GR, et al. Myocardial function defined by strain rate and strain during alterations in inotropic states and heart rate[J]. Am J Physiol Heart Circ Physiol,2002,283(2):792-799.
[42]周亚静,王建华,杜丽娟.应变率成像评价不同构型高血压病患者左房功能[J].中国医学影像技术,2008,24(4)：538-540.
[43]黄国庆,李国杰,高枫等.应变率成像技术及彩色多普勒血流成像技术对原发性高血压病左房功能的定量评价[J].现代实用医学,2010,22(1)：87-88.
[44]张彦华,朱向明,方少兵.应变率成像技术定量评价高血压病左房功能的临床研究[J].实用医学杂志,2009,25(16)：2688-2690.
[45]邓燕,郭盛兰,马国添,等.应变率成像评估左心室不同舒张功能状态患者左心房功能[J].临床荟萃,2009,24(18)：1574-1577.
[46]金玲,龚渭冰,翟连会,等.应变率显像对原发性高血压患者心功能的评价[J].新乡医学院学报,2010,27(5)：481-483.
[47]Shi Y, Li D, Tardif JC, Nattel S. Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure [J]. Cardiovasc Res,2002,54:456-461.
[48]Healey JS, Baranchuk A, Crystal E, et al. Prevention of atrial fibrillation with angiotensin converting enzyme inhibitors and angiotensin receptor blockers:a meta-analysis [J]. J Am Coll Cardiol,2005,45:1832-1839.
[49]王彪,姚成立,刘霞.RAS抑制剂对高血压患者左心房功能的影响[J].宁夏医科大学学报.2009,31(3)：308-310.
[50]Tada T, Oki T, Abe M, et al. The role of short-axis and long-axis function in determining late diastolic left ventricular filling in patients with hypertension: assessment by pulsed Doppler tissue imaging [J].I Am Soc Echocardiogr, 2002,15(10 P:2):1211-1217.
[51]Yip G, Abraham T, Belohlavek M, et al. Clinical applications of strain rate imaging[J].I Am Soc Echocardiogr,2003,1612):1334-1342.
[52]Schneider C, Malisius R, Krause K, et al. Strain rate imaging for functional quantification of the left atrium:atrial deformation predicts the maintenance of sinus rhythm after eatheter ablation of atrial fibrillation [J].Eur Heart J, 2008,29(11):1397-1409.
[53]D'Andren A, De Corato G,Scarafile R,et al.Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy:a two-dimensional speckle strain study [J].Br J Sports Med,2008,42(8):696-702.
[54]肖小鹏,邓林云,汤冬梅.应变率成像技术定量评价原发性高血压患者左房功能的价值[J].江西医药,2009,44(3)：202-204.
[55]Dandel M, Hetzer R.Echocardiographic strain and strain rate imaging—clinical applications [J]. Int Cardiol,2009,132(1):11-24.
[56]Abraham TP,Belohlavek M,Thomson HL,et al.Time to onset of regional relaxa-tion:feasibility,variability and utility of a novel index of regional myocardial function by strain rate imaging [J].J Am Coll Cardiol,2002,39(9):1531.
[57]Langeland S,D'Hooge J,Wouters PF,et al.Experimental validation of a new ultrasound met hold for the simultaneous assessment of radial and longitudinal myocardial deformation independent of insonation angle[J]. Circulation, 2005,112(14):2157-2162.
[58]Leitman M,Lysyansky P,Sidenko S,et al.Two-dimension Strain anovel software for real-time quantitative echocardiograpic assessment of myocardial function [J]J Am Soc Echocardiogr,2004,17(10):1021-1029.
[59]Kim DG,Lee KJ, Lee S. Feasibility of two-dimensional global longitudinal strain and strain rate imaging for the assessment of left atrial function:a study in subjects with a low probability of cardiovascular disease and normal exercise capacity[J]. Echocardiography,2009,26 (10):1179-1187.
[60]杨颖,陈峰,齐丽彤,等.二维应变与组织多普勒评价心肌应变的对比研究[J].中国超声医学杂,2006,22(11)：834-836.
[61]Teske A J,De Boeck B W,Olimulder M,et al.Echocardiographic assessment of regional right ventricular function:a head-to-head comparison between 2-dimensional and tissue Doppler-derived strain analysis[J].J Am Soc Echo-cardiogr,2007,21(3):275-283.
[62]Korinek J,Kjaergaard J,Sengupta P P,et al.High spatial resolution speckle tracking improves accuracy of 2-dimensional strain measurements[J] J Am Soc Echocardiogr,2007,20(2):165-170.
[63]Vianna-Pinton R,Moreno CA,Baxter CM,et al.Two-dimensional speckle-tracking echocardiography of the left atrium feasibility and regional contraction and relaxation differences in normal subjects[J]. J Am Soc Echocardiogr,2009,22(3): 299-305.