椎间盘纤维环交感神经分布特点与青少年特发性脊柱侧凸发病的相关研究
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摘要
目的探讨椎间盘纤维环交感神经分布与青少年特发性脊柱侧凸发病的相关性。方法先建立山羊脊柱侧凸模型,将椎间盘纤维环分为左前、左后、右前、右后四个区,然后通过NF200常规荧光组化和乙醛酸染色来研究正常山羊、侧凸山羊、正常人和青少年特发性脊柱侧凸患者椎间盘不同部位纤维环的交感神经分布特点。结果成功构建山羊脊柱侧凸模型,研究发现正常山羊椎间盘纤维环四个区的交感神经分布无显著差异;侧凸山羊顶椎区椎间盘凸凹侧纤维环交感神经分布无显著差异;正常人椎间盘纤维环四个区的交感神经分布无显著差异;青少年特发性脊柱侧凸患者顶椎区椎间盘凸凹侧纤维环交感神经分布有显著差异,凸侧明显多于凹侧。结论椎间盘纤维环左右两侧的交感神经分布差异可能是青少年特发性脊柱侧凸的发病原因之一。
Objective To study the associativity between the distribution of sympathetic nerve in annulus fibrosus disci intervertebralis and the onset of adolescent idiopathic scoliosis.Methods First,create goat scoliosis model.Each intervertebral disc is divided into four sections-the front left disc,the rear left disc,the front right disc and the rear right disc.Then study sympathetic nerves distribution characteristic of various section in annulus fibrosus disci intervertebralis of goat through NF200 conventional fluorescence dyeing and glyoxalic acid dyeing. meanwhile,scoliosis goats,normal peoples,and AISs,using the same method.
Results Succeed in establishing goat scoliosis model.Result shows that there is no significant difference in distribution of any two(out of four) sections' sympathetic nerve in normal goats annulus fibrosus disci intervertebralis,there is no significant difference between the sympathetic fibers distribution of convex side and concave side in annulus fibrosus disci intervertebralis of scoliosis goat apical vertebral,there is no significant difference in distribution of any two(out of four) sections' sympathetic fiber in normal peoples annulus fibrosus disci intervertebralis,and there is significant difference between the sympathetic fiber distribution of convex side and concave side in annulus fibrosus disci intervertebralis of AIS apical vertebral-the sympathetic nerve supply of convex side to gain advantage concave side.Conclusions Left and right difference in the distribution of sympathetic nerve in annulus fibrosus disci intervertebralis may be one of etiopathogenisis to the onset of adolescent idiopathic scoliosis.
Objective To study the associativity between the distribution of sympathetic nerve in annulus fibrosus disci intervertebralis and the onset of adolescent idiopathic scoliosis.Methods First,create goat scoliosis model.Each intervertebral disc is divided into four sections-the front left disc,the rear left disc,the front right disc and the rear right disc.Then study sympathetic nerves distribution characteristic of various section in annulus fibrosus disci intervertebralis of goat through NF200 conventional fluorescence dyeing and glyoxalic acid dyeing. meanwhile,scoliosis goats,normal peoples,and AISs,using the same method.
Results Succeed in establishing goat scoliosis model.Result shows that there is no significant difference in distribution of any two(out of four) sections' sympathetic nerve in normal goats annulus fibrosus disci intervertebralis,there is no significant difference between the sympathetic fibers distribution of convex side and concave side in annulus fibrosus disci intervertebralis of scoliosis goat apical vertebral,there is no significant difference in distribution of any two(out of four) sections' sympathetic fiber in normal peoples annulus fibrosus disci intervertebralis,and there is significant difference between the sympathetic fiber distribution of convex side and concave side in annulus fibrosus disci intervertebralis of AIS apical vertebral-the sympathetic nerve supply of convex side to gain advantage concave side.Conclusions Left and right difference in the distribution of sympathetic nerve in annulus fibrosus disci intervertebralis may be one of etiopathogenisis to the onset of adolescent idiopathic scoliosis.
引文
[1]Thometz J G,Liu X C,Lyon R.Three-dimensional rotations of the thoracic spine after distraction with and without rib resection:A kinematic evaluation of the apical vertebra in rabbits with induced scoliosis.J Spinal Disord,2000,13(2):108-112.
[2]Braun JT,Ogilvie JW,Akyuz E,et al.Creation of an experimental idiopathictype scoliosis in an immature goat model using a flexible posterior asymmetric tether.Spine,2006,31:1410-1414.
[3]Justice C M,Miller N H,Marosy B,et al.Familial idiopathic seoliosis:Evidence of an x-linked susceptibility locus.Spine,2003,28(6):589-594.
[4]Pal GP,Bhatt RH,Patel VS.Mechanism of production of experimental scoliosis in rabbits.Spine,1991,(2):137-142.
[5]Wall EJ.Bylski-Austrow DI.Kolata RJ,et al.Endoscopic mechanical spinal hemiepiphysiodesis modified spine growth.Spine,2005,30(10):1148-1153.
[6]Yamada K,Yamamoto H,Nakagawa Y,et al.Etiology of idiopathic seoliosis.Clin Orthop,1984,184:50-57.
[7]Sevastik J,Agadir M,Sevastik B.Effects of rib elongation on the spine(Ⅰ):distortion of the vertebral alignment in the rabbit.Spine,1990,15(8):822-825.
[8]Beuerlein M,Wilson J,Moreau M,et al,The critical stage ofpinealeetomy surgery after which scoliosis is produced in young chickens.Spine,2001,26(3):237-240.
[9]Kallemeier PM,Buttermann GR,Beaubien BP,et al.Validation,reliability,and complications of a tethering scoliosis model in the rabbit.Eur Spine J,2006,15:449-456.
[10]邓国权,张永刚,张魏,等.单侧椎弓根钉内固定建立新型山羊脊柱侧凸模型的实验研究.脊柱外科杂志,2007,5(1):29-32.
[11]Braun JT,Akyuz E,Udall H,et al.Thtee-dimensional analysis of 2 fusionless scolisis treatment:a flexible ligament tether verus a rigid-shaped memory alloy staple.Spine,2006,31(3):262-268.
[12]Carpintero P,Mesa M,Garcia J,et al.Scoliosis induced by asymmetric lordosis and rotation:an experimental study.Spine,1997,22(19):2202-2206.
[1]Lowe TG,Edgar M,Margulies JY.Etiology of idiopathic scoliosis:current trends in research.J Bone Joint Surg(Am),2000,82(8):1157-1168.
[2]Porter RW.The pathogenesis of idiopathic seoliosis:uncoupled neuroosseotls growth?.Eur Spine J,2001.10(6):473-481.
[3]Heidari B,FitzPatrick D,Synnott K,et al.Modelling of annulus fibrosus imbalance as an aetiological factor in adolescent idiopathic scoliosis.Clin Biomech,2004,19(3):217-224.
[4]Scott JE,Bosworth TR,Cribb AM.et al.The chenfical morphology of agrelated changes in human intervertebral disc glycosaminoglycans from cervical,thoracic and lumbar nucleus pulposus and annulus fibmsus.J Anat,1994,184(Pt-1):73-82.
[5]Sztrolovics R,Alini M.Roughley PJ,et al.Aggrecan degradation in human intervertebral disc and articular cartilage.Biochem J,1997,326(Pt 1):235-241.
[6]Inkinen RI,Lammi MJ,Lehmonen S,et al.Relative increase of biglycan and decorin and altered chondroltin sulfate epltopes in the degenerating human intervertebral disc.J Rheumatol.1998,25(3):506-514.
[7]Nakamaura S,Takahashi K,Takahashi Y,etal.Origin of supplying the posterior portion of lumbar intervertebra discs in rats.Spine,1996,21(8):917-924.
[8]Palmgren T,Gronblad M,Virri J,et al.Aa immunohistochem ical study of nerve structures in the anulus fibrosus of human nomal lumbar intervertebral discs.Spine,1999,24(20):2075-2079.
[9]Bogduk N.The innervation of the lumbar spine.Spine,1983,8(3):286-293.
[10]Groen GJ,Balijet B,Drukker J.Nerves and nerve plexuses of the human vertebral column.The Am J Anat,1990,188(2):282-196.
[11]Ahmed M,Bjurholm A,Kreicbergs A,et al.Neuropeptids Y,tyrosine hydoxylase and asoactive ineestinal polypeptide-immunoreactive nerve fibers in the vertebal bodies,discs,furamatterr,and spinal ligament of the rat lumbar spine.Spine,1993,18(2):186-192.
[12]Cavanaugh J,Kallakuri S,Ozaktay AC.Innervation of the rabbit lumbar intervertebral disc and posterior longitudinal ligament.Spine,1995,21(19):2080-2085.
[13]Tove P,Gronblad M,Virri J.Immunohistochemical demonstration of sensory and autonomic nerve terminals in herniated lumbar disc tissue.Spine,1996,21(11):1301-1306.
[14]于腾波,夏玉军,周秉文.颅外段椎动脉壁交感神经分布特点及其临床意义.青岛医学院学报.1999,35(4):244-246.
[1] Wall EJ,Bylski-Austrow DI,Kolata RJ,et al.Endoscopic mechanical spinal hemi-epiphysiodesis modified spine growth.Spine, 2005, 30 (10):1148-1153.
[2] Deguchi M,Kawakami N,Kanemura T,et al.Experimental scoliosis induced by rib resection in chickens.J Spinal Disord,1995,8 (3): 179-185.
[3] Pincott JR,Davies JS,Taffs LF.Scoliosis caused by section of dorsal spinal nerve roots.J Bone Joint Surg(Br),1984,66(1):27-29.
[4] Sevastik J,Agadir M,Sevastik B.Effects of rib elongation on the spine (I): distortion of the vertebral alignment in the rabbit.Spine, 1990, 15(8):822-825.
[5] Yamada K,Yamamoto H,Nakagawa Y,et al.Etiology of idiopathic seoliosis. Clin Orthop,1984,184:50-57.
[6] Sarwark JF,Dabney KW,Salzman SK,et al.Experimental scoliosis in the rat. Methodology, anatomic features and neurologic characterization.Spine,1988,5: 466- 471
[1]Ohtori S,Takahashi Y,Kazuhisa K,et al.Sensory innervation of the dorsalportion of the lumbar intervertebral disc in rats.Spine,1999,24:2295-2299.
[2]Aoki Y,Takahashi Y,Ohtori S,et al.Distribution and immunocytochemi cal characterization of dorsal root ganglion neurons innervating the lumbar intevertebrai-discin rats:a review.Life Sci,2004,74:2627-2642.
[3]Peng B,Wu W,Hou S,et al.The pathogenesis of discogenic low back pain.J Bone Joint Surg(Br),2005,87:62-67.
[4]Ahmed M,Bjurholm A,Kreicbergs A,et al.Neuropeptids Y,tyrosine hydroxylase and vasoactive intestinal polypeptide immunoreactive nerve fibers in the vertebral bodies,discs,dura mater,and spinal ligaments ofthe rat lumbar spine,spine,1993,18:186-192.
[5]Cavanaugh J,Kallakuri S,Ozaktay AC.Innervation of the rabbit lumbar intervertebral disc and posterior longitudinal ligament.Spine,1995,21:2080-2085.
[6]Tove P,Mats G,Johanna V,et al.An Immunohistochemical Study of Nerve Structures in the Anulus Fibrosus of Human Normal Lumbar Intervertebral Discs.Spine,24(20):2075-2079.
[7]Bogduk N.The innervation of the lumbar spine Spine,1983,8(3):286-293.
[1]Aulisa Lorenzo,Papaleo Pierangelo,Pola Enrico,et al.Association Between IL-6 and MMP-3 Gene Polymorphisms and Adolescent Idiopathic Scoliosis:A Case-control Study.Spine 2007,32(24):2700-2702.
[2]Inoue M,Minami S,Nakata Y.et al.Association between estrogen recaptor gene polymorphisms and curve severity of idiopathic scoliosis.Spine,2002,27(21):2357-2362.
[3]Wynne-Davies R.Familial(idiopathic)scoliosis:A family survey.J Bone Joint Surg(Sr),1968,50(1):24-30.
[4]Justic CM,Miller NH,Marosy B.Familial idiopathic scoliosis:Evidence ofan X-linked suseeptibilitylocus.Spine,2003,28(6):589-594.
[5]Burwell RG.A etiology of idiopathic sediosis:currentconcepts.Pediattic Rehabil.2003,6(3-4):137-170.
[6]Sahlstrand T,Petruson B,Ortengren R.Vestitmlospinal reflex activity in patients with adolescent idiopathie stoliosis.Postural effects during caloric labyrinthine stimulation recorded by stabilometry.Acta Orthop Scand,1979,50(3):275-28 I.
[7]Kapetanos G,Potoupnis M,Dangilas A.et al.Is the labyrinthine dysfunction acausative factor in idiopathic scoliosis.Stud HealthTech-nol Inform,2002,91:7-9.
[8]Manzoni D,Miele F.Vestibular mechanisms involved in idiopathic scoliosis.Arch Ital Biol,2002,140(1):67-80.
[9]Machida M,Dubousset J,Satoh T,et al.Pathologic mechanism of experimental scoliosis in pinealectomized chickens.Spine,2001,26(17):385-391.
[10]Machida M,Doubousset J,Imamura Y,et al.Melatonin:a possible role in pathogenesis of adolescent idiopathic scoliosis.Spine,1996,21(10):1147-1152.
[11]Bagnall KM,Beuerlein M,Johnson P,et al.Pineal transplantation after pinealectomy in young chickens has no effect on the development of scoliosis.Spine,2001,26(9):1022-1027.
[12]Hilibrand AS,Blakmore LC,Loder RT,et al.The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis.Spine,1996,21(10):1140-1146.
[13]Cheung J,Halbertsma JP,Veldhuizen AG,et al.A preliminary study on electromyographic analysis of the paraspinal musculature in idiopathic scoliesis.Eur Spine J.2005,14(2): 130-137.
[14]Maisenbacher MK,Han JS,O'brien ML,et al.Molecular analysis of congenital scoliosis:A candidata gone approach.Hum Genet,2005,116(5):416-419.
[15]Lowe T,Lawellin D,Smith D,et al,Platelet calmodulin levels in adolescent idiopathic scoliosis:do the levels correlate with curve progresssion and severity?.Spine,2002,27(7):768-775.
[16]Kindsfaster K,Lowe T,Lawell P,et al.Levels of palatelet calmodulin for the pridiction of progression and severity of adolescent idio- pathic scoliosis.J Bone Joiner Surg[Am],1994,76(8):1186-1192.
[17]朱锋,邱勇,郑伟娟,等.青少年特发性脊柱侧凸患者椎间盘纤维环胶原的分布及其意义.中国脊柱脊髓杂志,2004,14(4):233-236.
[18]Moreueride JA,Minhas R,Dolan L,etal,Allelic variants of human melatonin A receptor in patients with familial adolescent idiopathic scoliosis.Spine,2003,28(7):2025-2028.
[1]Heidari B,Fitzpatrick D,Synnott K,et al.Modelling of annulus fibrosus imbalance as an aetiological factor in adolescent idiopathic scoliosis.Clin Biomech,2004,19(3):217-224.
[2]Andersen,R.A,Snijder,L.H,Li,C.S,Stricance,B.Coordina to transformations in the repressentation of spatial information.Curr Opin Neurobiol,1993,3:171-176.
[3]Manzoni D,Miele F.Vestibular mechanisms involved in idiopathic scoliosis.Arch Ital Biol Jan,2002,140(1):67-80.
[4]Cheung J,Sluiter WJ,Veldhuizen AG,et al.Perception of vertical and horizontal orientation in children with scoliosis.J Orthop Res,2002,20(3):416-420.
[5]Catanzariti J,Selomez E,Bruandet J,et al.Visual deficiency and scolicsis.Spine,2001,26(1):48-52.
[6]Herman R,Mixon J,Fisher A,et al.Idiopathic scoliosis and the central nervous system la motor control problem.Spine,1985,10:1-14.
[7]Olafsson Y,Odergren T,Persson HE,et al.Somato sensory testing in idiopathic scoliosis[J].Dev Med Child Neurol,2002,44(2):130-132.
[8]王嵘,邱勇,芮碧宇,等.特发性脊柱侧凸患者椎旁肌中神经营养素3的表达及意义.中国脊柱脊髓杂志,2007,17(7):532-534.
[9]Machida M,Dubousset J,Imamura Y,et al.Pathogenesis of idiopathic scoliosis,SEPs in chicken with experimentally induced scoliosis and in patients with idiopathic scoliosis.J Pediatr Orthop,1994,14(3):1329-335.
[10]Brinker M,Willis J,Cook S,et al.Neurologic testing with somatosensory evoked potentials in idiopathic scoliosis.Spine,1992,17(3):277-279.
[11]Kesling KL,Reinker KA.Scoliosis in twins.A meta-analysis of the literature and report of six cases.Spine,1997,22(17):2009-2015.
[12]Axenovich TI,Zaidman AM,Zorkoltseva Ⅳ,et al.Segregation analysis of idiopathic scoliosis:demonstration of a major gene effect.Am J Med Genet,1999,86(4):389-394.
[13]Weiss HR.Idiopathic scoliosis:how much of a genetic disorder? Report of five pairs of monozygotic twins.Dev Neurorehabil.2007,10(1):67-73.
[14]Wise CA,Barnes R,Gillum J,et al.Localization of susceptibility to familial idiopathic scoliosis.Spine,2000,25(18):2372-2380.
[15]Justice CM,Miller NM,Marosy B,et al.Familial idiopathic scoliosis:evidence of an X-linked susceptibility locus.Spine,2003,28(6):589-594.
[16]Chan V,Fong CY,Luk DK,et al.A Genetic locus for adolescent idiopathic scoliosis linked to chromosome 19p13.3.Am J Hum Genet,2002,71(2):401-406.
[17]Inoue M,Minami s,Nakata Y,et al.Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosi.Spine,2002,12(4):2357-2362.
[18]Ford DM,Bagnall KM,McFadden KD,el al.Paraspinal muscle imbalance in adolescent idiopathic scoliosis.Spine.1984.9:373-376.
[19]邱勇,吴亮,王斌,等.脊柱侧凸椎旁肌肌纤维群化现象的研究.脊柱外科杂志,2005,3(4):215-218.
[20]Antoniou J,Arlet V,Goswami T,et al.Elevated synthetic activity in the convex side of scoliotic intervertebral discs and endplates compared with normal tissuees.Spine,2001,26:E198-206.
[21]朱峰,邱勇,郑晓刚,等.青少年特发性脊柱侧凸患者脊柱前后柱生长软骨的超微结构研究.电子纤维学报,2004,23(1):81-85.
[22]王守丰,邱勇,夏才伟,等.青少年特发性脊柱侧凸患者脊柱前后柱骨骺软骨的组织形态学对比研究.中国脊柱脊髓杂志,2007,17(4):1221-1224.
[23]邱勇,朱锋.特发性脊柱侧凸患者脊柱前后柱生长板的组织学形态.中国医学科学院学报.2005,27(2):148-152.
[24]Taylor JR.Scollosis and growth:patterns of asymmetry in normal vertebral growth.Acta Orthop Scand,1983,54(4):596-602.
[25]贺永雄,邱勇,王斌,等.脊柱侧凸顶椎区椎间盘纤维环多聚蛋白多糖的表达及意义.中国脊柱脊髓杂志,2006,16(3):225-228.
[26]朱锋,邱勇,郑伟娟,等.青少年特发性脊柱侧凸患者椎间盘纤维环胶原的分布及其意义.中国脊柱脊髓杂志,2004,14(4):233-236.
[27]林琦,吴志宏,刘勇,等.特发性脊柱侧凸患者椎间盘中X型胶原基因的表达.中国医学科学院学报,2004,26(6):696-699.
[28]Lowe T,Lawellin D,Snfith D,et al.Platelet cahnodulin levels in adolescent idiopathic scoliosis:do the levels correlate with curve progression and severity? Spine,2002, 27(7):768-775.
[29]Kindsfater K,Lowe T,Lawellin D,et al.Levels of plateletcalnlulm for the prediction of progression and seventy of adolescent idiopathic scoliosis.J Bone Joint Surg Am,1994,76(8):1186-1192.
[30]Ylikoski M.Height of girls with adolestent idiopathic scoliosis.Eur Spine J,2003,12(3):288-291.
[31]吴洁,邱勇,张乐,等.青少年特发性脊侧凸患者骨组织中雌激素受体的表达.中国脊柱脊髓杂志,2007,17(7):528-531.
[32]Porter RW.Can a short spinal cord cause idiopathic scoliosis? Eur Spine J,2001,10(1):2-9.
[33]Nette F,Dolynchuk K,Wang X,et al.The effects of exposure to intense,24h light on the developpment of scoliosis in young chickens.Stud Health Technol Inform,2002,91(4):1-6.
[34]Suh KT,Lee SS,Kim SJ,et al.Pineal gland metabolism in patients with adolescent idiopathic scoliosis.J Bone Joint Surg Br.2007,89(1):66-71.
[35]Machida M.Cause of idiopathic scoliosis.Spine,1999,24(24):2576-2583.
[36]Morean A,Wang da S,Forget s,et al.Melatonin signaling dysfunction in adolescent idiopathic scoliosis.Spine,2004,29(16):1772.
[37]朱晓东,李明,白玉树,等.不同剂量褪黑素对松果体切除鸡脊柱侧凸发生率的影响.中华骨科杂志,2004,24(7):436-438.
[38]Letellier K,Azeddine B,Blain S,et al.Etiopathogenesis of adolescent idiopathic scoliosis and new molecular concepts.Med Sci(Paris),2007,23(11):910-6.,
[39]Cheung J,Halbertsma JP,Veldhuizen AG,et al.A preliminary study on electromyographic analysis of the paraspinal musculature in idiopathic sediesis.Eur Spine J,2005,14(2):130-137
[2]Braun JT,Ogilvie JW,Akyuz E,et al.Creation of an experimental idiopathictype scoliosis in an immature goat model using a flexible posterior asymmetric tether.Spine,2006,31:1410-1414.
[3]Justice C M,Miller N H,Marosy B,et al.Familial idiopathic seoliosis:Evidence of an x-linked susceptibility locus.Spine,2003,28(6):589-594.
[4]Pal GP,Bhatt RH,Patel VS.Mechanism of production of experimental scoliosis in rabbits.Spine,1991,(2):137-142.
[5]Wall EJ.Bylski-Austrow DI.Kolata RJ,et al.Endoscopic mechanical spinal hemiepiphysiodesis modified spine growth.Spine,2005,30(10):1148-1153.
[6]Yamada K,Yamamoto H,Nakagawa Y,et al.Etiology of idiopathic seoliosis.Clin Orthop,1984,184:50-57.
[7]Sevastik J,Agadir M,Sevastik B.Effects of rib elongation on the spine(Ⅰ):distortion of the vertebral alignment in the rabbit.Spine,1990,15(8):822-825.
[8]Beuerlein M,Wilson J,Moreau M,et al,The critical stage ofpinealeetomy surgery after which scoliosis is produced in young chickens.Spine,2001,26(3):237-240.
[9]Kallemeier PM,Buttermann GR,Beaubien BP,et al.Validation,reliability,and complications of a tethering scoliosis model in the rabbit.Eur Spine J,2006,15:449-456.
[10]邓国权,张永刚,张魏,等.单侧椎弓根钉内固定建立新型山羊脊柱侧凸模型的实验研究.脊柱外科杂志,2007,5(1):29-32.
[11]Braun JT,Akyuz E,Udall H,et al.Thtee-dimensional analysis of 2 fusionless scolisis treatment:a flexible ligament tether verus a rigid-shaped memory alloy staple.Spine,2006,31(3):262-268.
[12]Carpintero P,Mesa M,Garcia J,et al.Scoliosis induced by asymmetric lordosis and rotation:an experimental study.Spine,1997,22(19):2202-2206.
[1]Lowe TG,Edgar M,Margulies JY.Etiology of idiopathic scoliosis:current trends in research.J Bone Joint Surg(Am),2000,82(8):1157-1168.
[2]Porter RW.The pathogenesis of idiopathic seoliosis:uncoupled neuroosseotls growth?.Eur Spine J,2001.10(6):473-481.
[3]Heidari B,FitzPatrick D,Synnott K,et al.Modelling of annulus fibrosus imbalance as an aetiological factor in adolescent idiopathic scoliosis.Clin Biomech,2004,19(3):217-224.
[4]Scott JE,Bosworth TR,Cribb AM.et al.The chenfical morphology of agrelated changes in human intervertebral disc glycosaminoglycans from cervical,thoracic and lumbar nucleus pulposus and annulus fibmsus.J Anat,1994,184(Pt-1):73-82.
[5]Sztrolovics R,Alini M.Roughley PJ,et al.Aggrecan degradation in human intervertebral disc and articular cartilage.Biochem J,1997,326(Pt 1):235-241.
[6]Inkinen RI,Lammi MJ,Lehmonen S,et al.Relative increase of biglycan and decorin and altered chondroltin sulfate epltopes in the degenerating human intervertebral disc.J Rheumatol.1998,25(3):506-514.
[7]Nakamaura S,Takahashi K,Takahashi Y,etal.Origin of supplying the posterior portion of lumbar intervertebra discs in rats.Spine,1996,21(8):917-924.
[8]Palmgren T,Gronblad M,Virri J,et al.Aa immunohistochem ical study of nerve structures in the anulus fibrosus of human nomal lumbar intervertebral discs.Spine,1999,24(20):2075-2079.
[9]Bogduk N.The innervation of the lumbar spine.Spine,1983,8(3):286-293.
[10]Groen GJ,Balijet B,Drukker J.Nerves and nerve plexuses of the human vertebral column.The Am J Anat,1990,188(2):282-196.
[11]Ahmed M,Bjurholm A,Kreicbergs A,et al.Neuropeptids Y,tyrosine hydoxylase and asoactive ineestinal polypeptide-immunoreactive nerve fibers in the vertebal bodies,discs,furamatterr,and spinal ligament of the rat lumbar spine.Spine,1993,18(2):186-192.
[12]Cavanaugh J,Kallakuri S,Ozaktay AC.Innervation of the rabbit lumbar intervertebral disc and posterior longitudinal ligament.Spine,1995,21(19):2080-2085.
[13]Tove P,Gronblad M,Virri J.Immunohistochemical demonstration of sensory and autonomic nerve terminals in herniated lumbar disc tissue.Spine,1996,21(11):1301-1306.
[14]于腾波,夏玉军,周秉文.颅外段椎动脉壁交感神经分布特点及其临床意义.青岛医学院学报.1999,35(4):244-246.
[1] Wall EJ,Bylski-Austrow DI,Kolata RJ,et al.Endoscopic mechanical spinal hemi-epiphysiodesis modified spine growth.Spine, 2005, 30 (10):1148-1153.
[2] Deguchi M,Kawakami N,Kanemura T,et al.Experimental scoliosis induced by rib resection in chickens.J Spinal Disord,1995,8 (3): 179-185.
[3] Pincott JR,Davies JS,Taffs LF.Scoliosis caused by section of dorsal spinal nerve roots.J Bone Joint Surg(Br),1984,66(1):27-29.
[4] Sevastik J,Agadir M,Sevastik B.Effects of rib elongation on the spine (I): distortion of the vertebral alignment in the rabbit.Spine, 1990, 15(8):822-825.
[5] Yamada K,Yamamoto H,Nakagawa Y,et al.Etiology of idiopathic seoliosis. Clin Orthop,1984,184:50-57.
[6] Sarwark JF,Dabney KW,Salzman SK,et al.Experimental scoliosis in the rat. Methodology, anatomic features and neurologic characterization.Spine,1988,5: 466- 471
[1]Ohtori S,Takahashi Y,Kazuhisa K,et al.Sensory innervation of the dorsalportion of the lumbar intervertebral disc in rats.Spine,1999,24:2295-2299.
[2]Aoki Y,Takahashi Y,Ohtori S,et al.Distribution and immunocytochemi cal characterization of dorsal root ganglion neurons innervating the lumbar intevertebrai-discin rats:a review.Life Sci,2004,74:2627-2642.
[3]Peng B,Wu W,Hou S,et al.The pathogenesis of discogenic low back pain.J Bone Joint Surg(Br),2005,87:62-67.
[4]Ahmed M,Bjurholm A,Kreicbergs A,et al.Neuropeptids Y,tyrosine hydroxylase and vasoactive intestinal polypeptide immunoreactive nerve fibers in the vertebral bodies,discs,dura mater,and spinal ligaments ofthe rat lumbar spine,spine,1993,18:186-192.
[5]Cavanaugh J,Kallakuri S,Ozaktay AC.Innervation of the rabbit lumbar intervertebral disc and posterior longitudinal ligament.Spine,1995,21:2080-2085.
[6]Tove P,Mats G,Johanna V,et al.An Immunohistochemical Study of Nerve Structures in the Anulus Fibrosus of Human Normal Lumbar Intervertebral Discs.Spine,24(20):2075-2079.
[7]Bogduk N.The innervation of the lumbar spine Spine,1983,8(3):286-293.
[1]Aulisa Lorenzo,Papaleo Pierangelo,Pola Enrico,et al.Association Between IL-6 and MMP-3 Gene Polymorphisms and Adolescent Idiopathic Scoliosis:A Case-control Study.Spine 2007,32(24):2700-2702.
[2]Inoue M,Minami S,Nakata Y.et al.Association between estrogen recaptor gene polymorphisms and curve severity of idiopathic scoliosis.Spine,2002,27(21):2357-2362.
[3]Wynne-Davies R.Familial(idiopathic)scoliosis:A family survey.J Bone Joint Surg(Sr),1968,50(1):24-30.
[4]Justic CM,Miller NH,Marosy B.Familial idiopathic scoliosis:Evidence ofan X-linked suseeptibilitylocus.Spine,2003,28(6):589-594.
[5]Burwell RG.A etiology of idiopathic sediosis:currentconcepts.Pediattic Rehabil.2003,6(3-4):137-170.
[6]Sahlstrand T,Petruson B,Ortengren R.Vestitmlospinal reflex activity in patients with adolescent idiopathie stoliosis.Postural effects during caloric labyrinthine stimulation recorded by stabilometry.Acta Orthop Scand,1979,50(3):275-28 I.
[7]Kapetanos G,Potoupnis M,Dangilas A.et al.Is the labyrinthine dysfunction acausative factor in idiopathic scoliosis.Stud HealthTech-nol Inform,2002,91:7-9.
[8]Manzoni D,Miele F.Vestibular mechanisms involved in idiopathic scoliosis.Arch Ital Biol,2002,140(1):67-80.
[9]Machida M,Dubousset J,Satoh T,et al.Pathologic mechanism of experimental scoliosis in pinealectomized chickens.Spine,2001,26(17):385-391.
[10]Machida M,Doubousset J,Imamura Y,et al.Melatonin:a possible role in pathogenesis of adolescent idiopathic scoliosis.Spine,1996,21(10):1147-1152.
[11]Bagnall KM,Beuerlein M,Johnson P,et al.Pineal transplantation after pinealectomy in young chickens has no effect on the development of scoliosis.Spine,2001,26(9):1022-1027.
[12]Hilibrand AS,Blakmore LC,Loder RT,et al.The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis.Spine,1996,21(10):1140-1146.
[13]Cheung J,Halbertsma JP,Veldhuizen AG,et al.A preliminary study on electromyographic analysis of the paraspinal musculature in idiopathic scoliesis.Eur Spine J.2005,14(2): 130-137.
[14]Maisenbacher MK,Han JS,O'brien ML,et al.Molecular analysis of congenital scoliosis:A candidata gone approach.Hum Genet,2005,116(5):416-419.
[15]Lowe T,Lawellin D,Smith D,et al,Platelet calmodulin levels in adolescent idiopathic scoliosis:do the levels correlate with curve progresssion and severity?.Spine,2002,27(7):768-775.
[16]Kindsfaster K,Lowe T,Lawell P,et al.Levels of palatelet calmodulin for the pridiction of progression and severity of adolescent idio- pathic scoliosis.J Bone Joiner Surg[Am],1994,76(8):1186-1192.
[17]朱锋,邱勇,郑伟娟,等.青少年特发性脊柱侧凸患者椎间盘纤维环胶原的分布及其意义.中国脊柱脊髓杂志,2004,14(4):233-236.
[18]Moreueride JA,Minhas R,Dolan L,etal,Allelic variants of human melatonin A receptor in patients with familial adolescent idiopathic scoliosis.Spine,2003,28(7):2025-2028.
[1]Heidari B,Fitzpatrick D,Synnott K,et al.Modelling of annulus fibrosus imbalance as an aetiological factor in adolescent idiopathic scoliosis.Clin Biomech,2004,19(3):217-224.
[2]Andersen,R.A,Snijder,L.H,Li,C.S,Stricance,B.Coordina to transformations in the repressentation of spatial information.Curr Opin Neurobiol,1993,3:171-176.
[3]Manzoni D,Miele F.Vestibular mechanisms involved in idiopathic scoliosis.Arch Ital Biol Jan,2002,140(1):67-80.
[4]Cheung J,Sluiter WJ,Veldhuizen AG,et al.Perception of vertical and horizontal orientation in children with scoliosis.J Orthop Res,2002,20(3):416-420.
[5]Catanzariti J,Selomez E,Bruandet J,et al.Visual deficiency and scolicsis.Spine,2001,26(1):48-52.
[6]Herman R,Mixon J,Fisher A,et al.Idiopathic scoliosis and the central nervous system la motor control problem.Spine,1985,10:1-14.
[7]Olafsson Y,Odergren T,Persson HE,et al.Somato sensory testing in idiopathic scoliosis[J].Dev Med Child Neurol,2002,44(2):130-132.
[8]王嵘,邱勇,芮碧宇,等.特发性脊柱侧凸患者椎旁肌中神经营养素3的表达及意义.中国脊柱脊髓杂志,2007,17(7):532-534.
[9]Machida M,Dubousset J,Imamura Y,et al.Pathogenesis of idiopathic scoliosis,SEPs in chicken with experimentally induced scoliosis and in patients with idiopathic scoliosis.J Pediatr Orthop,1994,14(3):1329-335.
[10]Brinker M,Willis J,Cook S,et al.Neurologic testing with somatosensory evoked potentials in idiopathic scoliosis.Spine,1992,17(3):277-279.
[11]Kesling KL,Reinker KA.Scoliosis in twins.A meta-analysis of the literature and report of six cases.Spine,1997,22(17):2009-2015.
[12]Axenovich TI,Zaidman AM,Zorkoltseva Ⅳ,et al.Segregation analysis of idiopathic scoliosis:demonstration of a major gene effect.Am J Med Genet,1999,86(4):389-394.
[13]Weiss HR.Idiopathic scoliosis:how much of a genetic disorder? Report of five pairs of monozygotic twins.Dev Neurorehabil.2007,10(1):67-73.
[14]Wise CA,Barnes R,Gillum J,et al.Localization of susceptibility to familial idiopathic scoliosis.Spine,2000,25(18):2372-2380.
[15]Justice CM,Miller NM,Marosy B,et al.Familial idiopathic scoliosis:evidence of an X-linked susceptibility locus.Spine,2003,28(6):589-594.
[16]Chan V,Fong CY,Luk DK,et al.A Genetic locus for adolescent idiopathic scoliosis linked to chromosome 19p13.3.Am J Hum Genet,2002,71(2):401-406.
[17]Inoue M,Minami s,Nakata Y,et al.Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosi.Spine,2002,12(4):2357-2362.
[18]Ford DM,Bagnall KM,McFadden KD,el al.Paraspinal muscle imbalance in adolescent idiopathic scoliosis.Spine.1984.9:373-376.
[19]邱勇,吴亮,王斌,等.脊柱侧凸椎旁肌肌纤维群化现象的研究.脊柱外科杂志,2005,3(4):215-218.
[20]Antoniou J,Arlet V,Goswami T,et al.Elevated synthetic activity in the convex side of scoliotic intervertebral discs and endplates compared with normal tissuees.Spine,2001,26:E198-206.
[21]朱峰,邱勇,郑晓刚,等.青少年特发性脊柱侧凸患者脊柱前后柱生长软骨的超微结构研究.电子纤维学报,2004,23(1):81-85.
[22]王守丰,邱勇,夏才伟,等.青少年特发性脊柱侧凸患者脊柱前后柱骨骺软骨的组织形态学对比研究.中国脊柱脊髓杂志,2007,17(4):1221-1224.
[23]邱勇,朱锋.特发性脊柱侧凸患者脊柱前后柱生长板的组织学形态.中国医学科学院学报.2005,27(2):148-152.
[24]Taylor JR.Scollosis and growth:patterns of asymmetry in normal vertebral growth.Acta Orthop Scand,1983,54(4):596-602.
[25]贺永雄,邱勇,王斌,等.脊柱侧凸顶椎区椎间盘纤维环多聚蛋白多糖的表达及意义.中国脊柱脊髓杂志,2006,16(3):225-228.
[26]朱锋,邱勇,郑伟娟,等.青少年特发性脊柱侧凸患者椎间盘纤维环胶原的分布及其意义.中国脊柱脊髓杂志,2004,14(4):233-236.
[27]林琦,吴志宏,刘勇,等.特发性脊柱侧凸患者椎间盘中X型胶原基因的表达.中国医学科学院学报,2004,26(6):696-699.
[28]Lowe T,Lawellin D,Snfith D,et al.Platelet cahnodulin levels in adolescent idiopathic scoliosis:do the levels correlate with curve progression and severity? Spine,2002, 27(7):768-775.
[29]Kindsfater K,Lowe T,Lawellin D,et al.Levels of plateletcalnlulm for the prediction of progression and seventy of adolescent idiopathic scoliosis.J Bone Joint Surg Am,1994,76(8):1186-1192.
[30]Ylikoski M.Height of girls with adolestent idiopathic scoliosis.Eur Spine J,2003,12(3):288-291.
[31]吴洁,邱勇,张乐,等.青少年特发性脊侧凸患者骨组织中雌激素受体的表达.中国脊柱脊髓杂志,2007,17(7):528-531.
[32]Porter RW.Can a short spinal cord cause idiopathic scoliosis? Eur Spine J,2001,10(1):2-9.
[33]Nette F,Dolynchuk K,Wang X,et al.The effects of exposure to intense,24h light on the developpment of scoliosis in young chickens.Stud Health Technol Inform,2002,91(4):1-6.
[34]Suh KT,Lee SS,Kim SJ,et al.Pineal gland metabolism in patients with adolescent idiopathic scoliosis.J Bone Joint Surg Br.2007,89(1):66-71.
[35]Machida M.Cause of idiopathic scoliosis.Spine,1999,24(24):2576-2583.
[36]Morean A,Wang da S,Forget s,et al.Melatonin signaling dysfunction in adolescent idiopathic scoliosis.Spine,2004,29(16):1772.
[37]朱晓东,李明,白玉树,等.不同剂量褪黑素对松果体切除鸡脊柱侧凸发生率的影响.中华骨科杂志,2004,24(7):436-438.
[38]Letellier K,Azeddine B,Blain S,et al.Etiopathogenesis of adolescent idiopathic scoliosis and new molecular concepts.Med Sci(Paris),2007,23(11):910-6.,
[39]Cheung J,Halbertsma JP,Veldhuizen AG,et al.A preliminary study on electromyographic analysis of the paraspinal musculature in idiopathic sediesis.Eur Spine J,2005,14(2):130-137
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