Effects of taraxasterol on adjuvant-induced arthritis in rats
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- 英文论文题名：Effects of taraxasterol on adjuvant-induced arthritis in rats
- 论文作者：Zhang Xuemei ; Wang Shasha ; Wang Ying ; Liu Xinyu
- 英文论文作者：Zhang Xuemei ; Wang Shasha ; Wang Ying ; Liu Xinyu ; Yanbian University
- 年：2016
- 作者机构：Yanbian University;
- 英文论文关键词：Taraxasterol ; Adjuvant arthritis ; Inflammation ; Rats ; Anti-arthritis
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：S853.74
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：1301k
- 原文格式：D
- 会议级别：全国
摘要
Purpose: Taraxasterol was isolated from the traditional Chinese medicinal herb Taraxacum which has been frequently used as a remedy for inflammatory diseases. In the present study, we determined the in vivo anti-arthritic effect of taraxasterol on arthritis induced by Freund's complete adjuvant(FCA) in rats.Methods: Rats were immunized with FCA by intradermal injection into the right hind metatarsal footpad, and were orally treated daily with taraxasterol at 2, 4 and 8 mg/kg from day 2 to 28 after immunization. Paw swelling, arthritis index, body weight, spleen index and thymus index were evaluated. The levels of TNF-α, IL-1β, PGE2, OPG and RANKL in sera were measured using ELISA. Histopathological changes in joint tissues were examined using hematoxylin and eosin(H&E).Results: Taraxasterol significantly suppressed paw swelling and arthritis index, attenuated body weight loss, decreased the spleen index and thymus index induced by FCA. Furthermore, taraxasterol significantly inhibited the overproduction of serum TNF-α, IL-1β, PGE2 and RANKL, and increased serum OPG production in FCA-induced rats. Histopathological examination indicated that taraxasterol attenuated synovial hyperplasia, bone and cartilage damage, and inflammatory cell infiltration.Conclustions: These results suggest that taraxasterol has the potential protective effect against FCA-induced arthritis in rats.
Purpose: Taraxasterol was isolated from the traditional Chinese medicinal herb Taraxacum which has been frequently used as a remedy for inflammatory diseases. In the present study, we determined the in vivo anti-arthritic effect of taraxasterol on arthritis induced by Freund's complete adjuvant(FCA) in rats.Methods: Rats were immunized with FCA by intradermal injection into the right hind metatarsal footpad, and were orally treated daily with taraxasterol at 2, 4 and 8 mg/kg from day 2 to 28 after immunization. Paw swelling, arthritis index, body weight, spleen index and thymus index were evaluated. The levels of TNF-α, IL-1β, PGE2, OPG and RANKL in sera were measured using ELISA. Histopathological changes in joint tissues were examined using hematoxylin and eosin(H&E).Results: Taraxasterol significantly suppressed paw swelling and arthritis index, attenuated body weight loss, decreased the spleen index and thymus index induced by FCA. Furthermore, taraxasterol significantly inhibited the overproduction of serum TNF-α, IL-1β, PGE2 and RANKL, and increased serum OPG production in FCA-induced rats. Histopathological examination indicated that taraxasterol attenuated synovial hyperplasia, bone and cartilage damage, and inflammatory cell infiltration.Conclustions: These results suggest that taraxasterol has the potential protective effect against FCA-induced arthritis in rats.
Purpose: Taraxasterol was isolated from the traditional Chinese medicinal herb Taraxacum which has been frequently used as a remedy for inflammatory diseases. In the present study, we determined the in vivo anti-arthritic effect of taraxasterol on arthritis induced by Freund's complete adjuvant(FCA) in rats.Methods: Rats were immunized with FCA by intradermal injection into the right hind metatarsal footpad, and were orally treated daily with taraxasterol at 2, 4 and 8 mg/kg from day 2 to 28 after immunization. Paw swelling, arthritis index, body weight, spleen index and thymus index were evaluated. The levels of TNF-α, IL-1β, PGE2, OPG and RANKL in sera were measured using ELISA. Histopathological changes in joint tissues were examined using hematoxylin and eosin(H&E).Results: Taraxasterol significantly suppressed paw swelling and arthritis index, attenuated body weight loss, decreased the spleen index and thymus index induced by FCA. Furthermore, taraxasterol significantly inhibited the overproduction of serum TNF-α, IL-1β, PGE2 and RANKL, and increased serum OPG production in FCA-induced rats. Histopathological examination indicated that taraxasterol attenuated synovial hyperplasia, bone and cartilage damage, and inflammatory cell infiltration.Conclustions: These results suggest that taraxasterol has the potential protective effect against FCA-induced arthritis in rats.
引文