The role of Syk in the pathogenesis of bacterial DNA-induced arthritis
详细信息 查看官网全文
- 英文论文题名：The role of Syk in the pathogenesis of bacterial DNA-induced arthritis
- 论文作者：Liu Huicheng ; Qiao Wei ; Deng Guo-Min
- 英文论文作者：Liu Huicheng ; Qiao Wei ; Deng Guo-Min ; Key Lab of Antibody Techniques of Ministry of Health ; Nanjing Medical University
- 年：2016
- 作者机构：Key Lab of Antibody Techniques of Ministry of Health,Nanjing Medical University;
- 英文论文关键词：Bacterial DNA ; Syk ; TLR9
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R593.22
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：1289k
- 原文格式：D
- 会议级别：全国
摘要
Objective: Bacterial DNA has immunostimulatory effect and can induce arthritis; inhibitor of Syk has therapeutic effect in patients with rheumatoid arthritis. In this study, we investigated the role of Syk in the pathogenesis of bacterial DNAinduced arthritis.Methods: We evaluated the role of Syk inhibitor in prevention and treatment of bacterial DNA-induced arthritis animal model and investigated the mechanism that Syk regulated bacterial DNA-induced arthritis. Results: We found that bacterial DNA induced arthritis; inhibitor of Syk R788 prevented and treated arthritis induced by bacterial DNA.Depletion of monocytes/macrophages significantly reduced incidence and severity of arthritis induced by bacterial DNA; Incidence and severity of arthritis induced by bacterial DNA were markedly decreased in TNF deficient mice compared to wild mice. Bacterial DNA stimulated monocytes/macrophages to assembly of lipid rafts that recruit Syk and Toll-like receptor 9(TLR9). Depletion of lipid rafts reduced severity of arthritis induced by bacterial DNA.Conclusions: Syk exerts important role in the pathogenesis of bacterial DNA-induced arthritis; Syk regulates signaling pathway of TLR through lipid rafts.
Objective: Bacterial DNA has immunostimulatory effect and can induce arthritis; inhibitor of Syk has therapeutic effect in patients with rheumatoid arthritis. In this study, we investigated the role of Syk in the pathogenesis of bacterial DNAinduced arthritis.Methods: We evaluated the role of Syk inhibitor in prevention and treatment of bacterial DNA-induced arthritis animal model and investigated the mechanism that Syk regulated bacterial DNA-induced arthritis. Results: We found that bacterial DNA induced arthritis; inhibitor of Syk R788 prevented and treated arthritis induced by bacterial DNA.Depletion of monocytes/macrophages significantly reduced incidence and severity of arthritis induced by bacterial DNA; Incidence and severity of arthritis induced by bacterial DNA were markedly decreased in TNF deficient mice compared to wild mice. Bacterial DNA stimulated monocytes/macrophages to assembly of lipid rafts that recruit Syk and Toll-like receptor 9(TLR9). Depletion of lipid rafts reduced severity of arthritis induced by bacterial DNA.Conclusions: Syk exerts important role in the pathogenesis of bacterial DNA-induced arthritis; Syk regulates signaling pathway of TLR through lipid rafts.
Objective: Bacterial DNA has immunostimulatory effect and can induce arthritis; inhibitor of Syk has therapeutic effect in patients with rheumatoid arthritis. In this study, we investigated the role of Syk in the pathogenesis of bacterial DNAinduced arthritis.Methods: We evaluated the role of Syk inhibitor in prevention and treatment of bacterial DNA-induced arthritis animal model and investigated the mechanism that Syk regulated bacterial DNA-induced arthritis. Results: We found that bacterial DNA induced arthritis; inhibitor of Syk R788 prevented and treated arthritis induced by bacterial DNA.Depletion of monocytes/macrophages significantly reduced incidence and severity of arthritis induced by bacterial DNA; Incidence and severity of arthritis induced by bacterial DNA were markedly decreased in TNF deficient mice compared to wild mice. Bacterial DNA stimulated monocytes/macrophages to assembly of lipid rafts that recruit Syk and Toll-like receptor 9(TLR9). Depletion of lipid rafts reduced severity of arthritis induced by bacterial DNA.Conclusions: Syk exerts important role in the pathogenesis of bacterial DNA-induced arthritis; Syk regulates signaling pathway of TLR through lipid rafts.
引文