Genetic diversity of subgenotype 2.1 isolates of classical swine fever virus
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- 英文论文题名：Genetic diversity of subgenotype 2.1 isolates of classical swine fever virus
- 论文作者：Wenjie Gong ; Jianmin Wu ; Zongji Lu ; Li Zhang ; Shaomin Qin ; Fenglian Chen ; Zhicheng Peng ; Qin Wang ; Ling Ma ; Anbin Bai ; Huancheng Guo ; Jishu Shi ; Changchun Tu
- 英文论文作者：Wenjie Gong ; Jianmin Wu ; Zongji Lu ; Li Zhang ; Shaomin Qin ; Fenglian Chen ; Zhicheng Peng ; Qin Wang ; Ling Ma ; Anbin Bai ; Huancheng Guo ; Jishu Shi ; Changchun Tu ; Military Veterinary Institute ; Academy of Military Medical Sciences ; Department of Anatomy and Physiology ; College of Veterinary Medicine ; Kansas State University ; Guangxi Veterinary Research Institute ; College of Life Science ; Foshan University ; College of Animal Science and Technology ; Jilin Agricultural University ; China Institute of Veterinary Drug Control ; National Classical Swine Fever Reference Laboratory ; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses
- 年：2016
- 作者机构：Military Veterinary Institute,Academy of Military Medical Sciences;Department of Anatomy and Physiology,College of Veterinary Medicine,Kansas State University;Guangxi Veterinary Research Institute;College of Life Science,Foshan University;College of Animal Science and Technology,Jilin Agricultural University;China Institute of Veterinary Drug Control,National Classical Swine Fever Reference Laboratory;Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses;
- 会议召开时间：2016-09-18
- 会议录名称：第六届中国兽药大会论文集
- 英文会议录名称：Proceedings of 2016 the 6th China Congress of Veterinary Medicine
- 语种：英文
- 分类号：S852.651
- 学会代码：ZGXJ
- 会议名称：第六届中国兽药大会
- 会议地点：中国四川成都
- 主办单位：中国兽医药品监察所、中国兽药协会
- 学会名称：中国畜牧兽医学会
- 页数：2
- 文件大小：128k
- 原文格式：O
- 会议级别：全国
摘要
As the causative agent of classical swine fever,the economically devastating swine disease worldwide,classical swine fever virus(CSFV) is currently classified into the 11 subgenotypes,of which subgenotype 2.1 is distributed worldwide and showing more genetic diversity than other subgenotypes.Prior to this report,subgenotype 2.1 was divided into three subsubgenotypes(2.1a-2.1c).To further analyze the genetic diversity of CSFV isolates in China,39 CSFV isolates collected between 2004-2012 in two Chinese provinces Guangxi and Guangdong were sequenced and subjected to phylogenetic analysis together with reference sequences retrieved from GenBank.Phylogenetic analyses based on the 190-nt and/or 1119-nt full length E2 gene fragments showed that current CSFV subgenotype 2.1 virus isolates in the world could be divided into 10 sub-subgenotypes(2.1a-2.1j) and the 39 isolates collected in this study were grouped into 7 of them(2.1a-2.1c and 2.1g-2.1j).Among the 10 sub-subgenotypes,2.1d-2.1j were newly identified.Sub-subgenotypes 2.1d isolates were circulated only in India,however the rest 9 sub-subgenotypes were from China with some of them closely related to isolates from European and neighboring Asian countries.According to the temporal and spatial distribution of CSFV subgenotype 2.1 isolates,the newly classified 10 sub-subgenotypes were further categorized into three groups:dominant sub-subgenotype,minor sub-subgenotype and silent sub-subgenotype,and each sub-subgenotype can be found only in certain geographical areas.Taken together,this study reveals the complex genetic diversity of CSFV subgenotype 2.1 and improves our understanding about the epidemiological trends of CSFV subgenotype 2.1 in the world,particularly in China.
As the causative agent of classical swine fever,the economically devastating swine disease worldwide,classical swine fever virus(CSFV) is currently classified into the 11 subgenotypes,of which subgenotype 2.1 is distributed worldwide and showing more genetic diversity than other subgenotypes.Prior to this report,subgenotype 2.1 was divided into three subsubgenotypes(2.1a-2.1c).To further analyze the genetic diversity of CSFV isolates in China,39 CSFV isolates collected between 2004-2012 in two Chinese provinces Guangxi and Guangdong were sequenced and subjected to phylogenetic analysis together with reference sequences retrieved from GenBank.Phylogenetic analyses based on the 190-nt and/or 1119-nt full length E2 gene fragments showed that current CSFV subgenotype 2.1 virus isolates in the world could be divided into 10 sub-subgenotypes(2.1a-2.1j) and the 39 isolates collected in this study were grouped into 7 of them(2.1a-2.1c and 2.1g-2.1j).Among the 10 sub-subgenotypes,2.1d-2.1j were newly identified.Sub-subgenotypes 2.1d isolates were circulated only in India,however the rest 9 sub-subgenotypes were from China with some of them closely related to isolates from European and neighboring Asian countries.According to the temporal and spatial distribution of CSFV subgenotype 2.1 isolates,the newly classified 10 sub-subgenotypes were further categorized into three groups:dominant sub-subgenotype,minor sub-subgenotype and silent sub-subgenotype,and each sub-subgenotype can be found only in certain geographical areas.Taken together,this study reveals the complex genetic diversity of CSFV subgenotype 2.1 and improves our understanding about the epidemiological trends of CSFV subgenotype 2.1 in the world,particularly in China.
As the causative agent of classical swine fever,the economically devastating swine disease worldwide,classical swine fever virus(CSFV) is currently classified into the 11 subgenotypes,of which subgenotype 2.1 is distributed worldwide and showing more genetic diversity than other subgenotypes.Prior to this report,subgenotype 2.1 was divided into three subsubgenotypes(2.1a-2.1c).To further analyze the genetic diversity of CSFV isolates in China,39 CSFV isolates collected between 2004-2012 in two Chinese provinces Guangxi and Guangdong were sequenced and subjected to phylogenetic analysis together with reference sequences retrieved from GenBank.Phylogenetic analyses based on the 190-nt and/or 1119-nt full length E2 gene fragments showed that current CSFV subgenotype 2.1 virus isolates in the world could be divided into 10 sub-subgenotypes(2.1a-2.1j) and the 39 isolates collected in this study were grouped into 7 of them(2.1a-2.1c and 2.1g-2.1j).Among the 10 sub-subgenotypes,2.1d-2.1j were newly identified.Sub-subgenotypes 2.1d isolates were circulated only in India,however the rest 9 sub-subgenotypes were from China with some of them closely related to isolates from European and neighboring Asian countries.According to the temporal and spatial distribution of CSFV subgenotype 2.1 isolates,the newly classified 10 sub-subgenotypes were further categorized into three groups:dominant sub-subgenotype,minor sub-subgenotype and silent sub-subgenotype,and each sub-subgenotype can be found only in certain geographical areas.Taken together,this study reveals the complex genetic diversity of CSFV subgenotype 2.1 and improves our understanding about the epidemiological trends of CSFV subgenotype 2.1 in the world,particularly in China.
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