The incidence of acutemountain sickness in passengers travel across the Tibetan plateau by train
详细信息 查看官网全文
- 英文论文题名：The incidence of acutemountain sickness in passengers travel across the Tibetan plateau by train
- 论文作者：Yong Wang ; Hong Jiang ; Lei Pan ; Lina Jia ; Yongjie Huang ; Jin Qian ; Xiaoyongma
- 英文论文作者：Yong Wang ; Hong Jiang ; Lei Pan ; Lina Jia ; Yongjie Huang ; Jin Qian ; Xiaoyongma ; Department of Gerontology ; Beijing Shijitan Hospital ; Capitalmedical University
- 年：2016
- 作者机构：Department of Gerontology,Beijing Shijitan Hospital,Capitalmedical University;
- 英文论文关键词：acutemountain sickness ; Tibetan plateau ; symptom ; altitude ; Introduction
- 会议召开时间：2016-06-25
- 会议录名称：青藏铁路运营十周年学术研讨会卫生系统论文集
- 语种：英文
- 分类号：R594.3
- 学会代码：ZGTD
- 会议名称：青藏铁路运营十周年学术研讨会
- 会议地点：中国西藏拉萨
- 主办单位：中国铁道学会、青海省科学技术协会、西藏自治区科学技术协会
- 学会名称：中国铁道学会
- 页数：12
- 文件大小：829k
- 原文格式：O
- 会议级别：全国
摘要
Purpose To investigate the incidence of acutemountain sickness(AMS) in common passengers,who were first exposed to high altitude by taking the Tibetan railway train,whether the symptoms of AMS were caused by the long journey or high altitude.The factors that contributed to the AMS were also discussed.Methods Volunteer passengers aged 18 to 70 years old travelled by trains at high altitude(Tibetan plateau) and low altitude(Urumqi railway) were selected consecutively.Their demographic information and AMS symptoms were collected by questionnaires.Physical parameters including respiratory rate,blood pressure,SpO_2,heart rate and heart function(NYHA) were recorded on the scheduled altitude and time.The four selected stations at high altitude were;Lanzhou(altitude 1600m-1800m),Xining(2500m-3100m),Naqu(4347m-5072m),and Lhasa(4141m-3671m).Three railway stations in control group were Yinchuan(1100m-1104m),before Wuwei(1451m-1529m) and before Urumqi(954m-987m),where the train travelled the same time as the first three high altitude stations.The diagnosis of AMS was according to Lake Louise score(LLS),based on presence of a headache,at least one other symptom,and a total score of 3 ormore on the self-report questionnaires.Results148 and 60 valid questionnaires in high altitude and low altitude trains were collected.Themajority of the participants were Han ethnicity.With the oxygen supplying system after 2500 m in high altitude train,the fraction of inspired oxygen at four stations was 21.0%,26.5%,22.1%and 24.3%,respectively.During the low altitude journey,the fraction of inspired oxygen was stable at 20.9%.The incidence of AMS in passengers travelled by train on Tibetan plateau was 20.2%,where the highest altitude was 5072 m.Among the symptoms of AMS,themost common symptom was headache(44.2%),and all the symptoms in high altitude group increased as the altitude increasing.Compared with control group,passengers travelling at high altitude would have higher blood pressure,and theirmean heart rate increased dramaticallymore than 10 bpm at 3671-5072 meters.NHYA increased slightly with the increasing of altitude.The decreasing of SpO_2 was consistent with the increasing of altitude.Heart rate,NYHA,SpO_2,altitude,BMI,gender and borg scale were correlated with the LLS score.Conclusion The incidence of AMS in passengers travelled at Tibetan plateau by train was not high.People exposed to high altitude were easier to show headache,dizziness and gastrointestinal symptoms,which led tomore incidence of AMS.SpO_2 decreased simultaneously as the altitude increasing,and heart rate increased dramatically at high altitude.The symptoms of AMS were correlated with altitude,BMI,gender,DPB,heart rate,and significant changes in SpO_2 at high altitude.The knowledge of AMS still needed to be improved in passengers in future studies.
Purpose To investigate the incidence of acutemountain sickness(AMS) in common passengers,who were first exposed to high altitude by taking the Tibetan railway train,whether the symptoms of AMS were caused by the long journey or high altitude.The factors that contributed to the AMS were also discussed.Methods Volunteer passengers aged 18 to 70 years old travelled by trains at high altitude(Tibetan plateau) and low altitude(Urumqi railway) were selected consecutively.Their demographic information and AMS symptoms were collected by questionnaires.Physical parameters including respiratory rate,blood pressure,SpO_2,heart rate and heart function(NYHA) were recorded on the scheduled altitude and time.The four selected stations at high altitude were;Lanzhou(altitude 1600m-1800m),Xining(2500m-3100m),Naqu(4347m-5072m),and Lhasa(4141m-3671m).Three railway stations in control group were Yinchuan(1100m-1104m),before Wuwei(1451m-1529m) and before Urumqi(954m-987m),where the train travelled the same time as the first three high altitude stations.The diagnosis of AMS was according to Lake Louise score(LLS),based on presence of a headache,at least one other symptom,and a total score of 3 ormore on the self-report questionnaires.Results148 and 60 valid questionnaires in high altitude and low altitude trains were collected.Themajority of the participants were Han ethnicity.With the oxygen supplying system after 2500 m in high altitude train,the fraction of inspired oxygen at four stations was 21.0%,26.5%,22.1%and 24.3%,respectively.During the low altitude journey,the fraction of inspired oxygen was stable at 20.9%.The incidence of AMS in passengers travelled by train on Tibetan plateau was 20.2%,where the highest altitude was 5072 m.Among the symptoms of AMS,themost common symptom was headache(44.2%),and all the symptoms in high altitude group increased as the altitude increasing.Compared with control group,passengers travelling at high altitude would have higher blood pressure,and theirmean heart rate increased dramaticallymore than 10 bpm at 3671-5072 meters.NHYA increased slightly with the increasing of altitude.The decreasing of SpO_2 was consistent with the increasing of altitude.Heart rate,NYHA,SpO_2,altitude,BMI,gender and borg scale were correlated with the LLS score.Conclusion The incidence of AMS in passengers travelled at Tibetan plateau by train was not high.People exposed to high altitude were easier to show headache,dizziness and gastrointestinal symptoms,which led tomore incidence of AMS.SpO_2 decreased simultaneously as the altitude increasing,and heart rate increased dramatically at high altitude.The symptoms of AMS were correlated with altitude,BMI,gender,DPB,heart rate,and significant changes in SpO_2 at high altitude.The knowledge of AMS still needed to be improved in passengers in future studies.
Purpose To investigate the incidence of acutemountain sickness(AMS) in common passengers,who were first exposed to high altitude by taking the Tibetan railway train,whether the symptoms of AMS were caused by the long journey or high altitude.The factors that contributed to the AMS were also discussed.Methods Volunteer passengers aged 18 to 70 years old travelled by trains at high altitude(Tibetan plateau) and low altitude(Urumqi railway) were selected consecutively.Their demographic information and AMS symptoms were collected by questionnaires.Physical parameters including respiratory rate,blood pressure,SpO_2,heart rate and heart function(NYHA) were recorded on the scheduled altitude and time.The four selected stations at high altitude were;Lanzhou(altitude 1600m-1800m),Xining(2500m-3100m),Naqu(4347m-5072m),and Lhasa(4141m-3671m).Three railway stations in control group were Yinchuan(1100m-1104m),before Wuwei(1451m-1529m) and before Urumqi(954m-987m),where the train travelled the same time as the first three high altitude stations.The diagnosis of AMS was according to Lake Louise score(LLS),based on presence of a headache,at least one other symptom,and a total score of 3 ormore on the self-report questionnaires.Results148 and 60 valid questionnaires in high altitude and low altitude trains were collected.Themajority of the participants were Han ethnicity.With the oxygen supplying system after 2500 m in high altitude train,the fraction of inspired oxygen at four stations was 21.0%,26.5%,22.1%and 24.3%,respectively.During the low altitude journey,the fraction of inspired oxygen was stable at 20.9%.The incidence of AMS in passengers travelled by train on Tibetan plateau was 20.2%,where the highest altitude was 5072 m.Among the symptoms of AMS,themost common symptom was headache(44.2%),and all the symptoms in high altitude group increased as the altitude increasing.Compared with control group,passengers travelling at high altitude would have higher blood pressure,and theirmean heart rate increased dramaticallymore than 10 bpm at 3671-5072 meters.NHYA increased slightly with the increasing of altitude.The decreasing of SpO_2 was consistent with the increasing of altitude.Heart rate,NYHA,SpO_2,altitude,BMI,gender and borg scale were correlated with the LLS score.Conclusion The incidence of AMS in passengers travelled at Tibetan plateau by train was not high.People exposed to high altitude were easier to show headache,dizziness and gastrointestinal symptoms,which led tomore incidence of AMS.SpO_2 decreased simultaneously as the altitude increasing,and heart rate increased dramatically at high altitude.The symptoms of AMS were correlated with altitude,BMI,gender,DPB,heart rate,and significant changes in SpO_2 at high altitude.The knowledge of AMS still needed to be improved in passengers in future studies.
引文
[1]Roach RC,Brtsch P,Oelz O,Hackett PH(1993).The Lake Louise acute mountain sickness scoring system.In:Hypoxia and molecular medicine.Sutton JR,Houston CS,Coates G,editors.Queen City Printers,Burlington,VT:272-274.
[2]Hackett PH,Rennie D,Levine HD(1976).The incidence,importance,and prophylaxis of acute mountain sickness.Lancet.2:1149-1155.
[3]Wu TY,Ding SQ,Zhang SL,Duan JQ,Li BY,Zhan ZY,Wu QL,Baomu S,Liang BZ,Han SR,Jie YL,Li G,Sun L,Kayser B.Altitude illness in Qinghai-Tibet railroad passengers.High Alt Med Biol.2010 Fall;ll(3):189-98.
[4]Milledge JS(1994).High altitude.In:Harries M,Williams C,et al.eds.Oxford University Press:255-270.
[5]Ward MP,Milledge Js(1995).High Altitude Medicine and Physiology.London,England:Chapman and Hall Medical.
[6]Wille M,Mairer K,Gatterer H,Philippe M,Faulhaber M,Burtscher M(2012).Changes in cardiac autonomic activity during a passive 8 hour acute exposure to 5?500 m normobaric hypoxia are not related to the development of acute mountain sickness.Int J Sports Med.33:186-191.
[7]Kayser B(1991).Acute mountain sickness in western tourists around the Thorong pass in Nepal.Journal of Wilderness Medicine.2:110-117.
[8]Schommer K,Brtsch P(2011).Basic medical advice for travelers to high altitudes.Dtsch Arztebl Int.108:839-847
[9]Mairer K,Wille M,Burtscher M(2010).The prevalence of and risk factors for acute mountain sickness in the Eastern and Western Alps.High Alt Med Biol.11:343-348.
[10]Jackson SJ,Varley J,Sellers C,Josephs K,Codrington L,Duke G,Njelekela MA,Drummond G,Sutherland AI,Thompson AA,Baillie JK(2010).Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro.High Alt Med Biol.11:217-222.
[11]Ren Y,Fu Z,Shen W,Jiang P,He Y,Peng S,Wu Z,Cui B(2010).Incidence of high altitude illnesses among unacclimatized persons who acutely ascended to Tibet.High Alt Med Biol.11:39-42.
[12]Silva-Urra JA,Urizar C,Basualto-Alarcón C,Torrella JR,Pages T,Behn C,Viscor G(2011).Effects of oxygen supplementation on acute mountain sickness symptoms and functional capacity during a 2-kilometer walk test on Chajnantor plateau(5050 meters,Northern Chile).Wilderness Environ Med.22:250-256.
[13]Gertsch JH,Lipman GS,Hoick PS,Merritt A,Mulcahy A,Fisher RS,Basnyat B,Allison E,Hanzelka K,Hazan A,Meyers Z,Odegaard J,Pook B,Thompson M,Slomovic B,Wahlberg H,Wilshaw V,Weiss EA,Zafren K(2010).Prospective,double-blind,randomized,placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache:the Headache Evaluation at Altitude Trial(HEAT).Wilderness Environ Med.21:236-243.
[14]Anderson PJ,Miller AD,OMalley KA,Ceridon ML,Beck KC,Wood CM,Wiste HJ,Mueller JJ,Johnson JB,Johnson BD(2011).Incidence and Symptoms of High Altitude Illness in South Pole Workers:Antarctic Study of Altitude Physiology(ASAP).Clin Med Insights Circ Respir Pulm Med.5:27-35.
[15]Richalet JP,Larmignat P,Poitrine E,Letournel M,Canou?-Poitrine F(2012).Physiological risk factors for severe highaltitude illness:a prospective cohort study.Am J Respir Crit Care Med.185:192-198.
[16]Imray CH,Kennedy CH,Pattinson K,Brearey S,Wright A;Brimingham Medical Research Expeditionary Society(2004).Self-assessment of acute mountain sickness in adolescents:a pilot study.Wilderness Environ Med.15:202-206.
[17]Karinen HM,Peltonen JE,Khnen M,Tikkanen HO(2010).Prediction of acute mountain sickness by monitoring arterial oxygen saturation during ascent.High Alt Med Biol.11;325-332.
[18]Croughs M,Van Compel A,Van den Ende J(2011).Acute mountain sickness in travelers who consulted a pre-travel clinic.J Travel Med.18:337-343.
[19]Li X,Tao F,You H,Pei T,Gao Y.Factors Associated With Acute Mountain Sickness in Young Chinese Men on Entering Highland Areas.Asia Pac J Public Health.2011 Dec 23.[Epub ahead of print]
[2]Hackett PH,Rennie D,Levine HD(1976).The incidence,importance,and prophylaxis of acute mountain sickness.Lancet.2:1149-1155.
[3]Wu TY,Ding SQ,Zhang SL,Duan JQ,Li BY,Zhan ZY,Wu QL,Baomu S,Liang BZ,Han SR,Jie YL,Li G,Sun L,Kayser B.Altitude illness in Qinghai-Tibet railroad passengers.High Alt Med Biol.2010 Fall;ll(3):189-98.
[4]Milledge JS(1994).High altitude.In:Harries M,Williams C,et al.eds.Oxford University Press:255-270.
[5]Ward MP,Milledge Js(1995).High Altitude Medicine and Physiology.London,England:Chapman and Hall Medical.
[6]Wille M,Mairer K,Gatterer H,Philippe M,Faulhaber M,Burtscher M(2012).Changes in cardiac autonomic activity during a passive 8 hour acute exposure to 5?500 m normobaric hypoxia are not related to the development of acute mountain sickness.Int J Sports Med.33:186-191.
[7]Kayser B(1991).Acute mountain sickness in western tourists around the Thorong pass in Nepal.Journal of Wilderness Medicine.2:110-117.
[8]Schommer K,Brtsch P(2011).Basic medical advice for travelers to high altitudes.Dtsch Arztebl Int.108:839-847
[9]Mairer K,Wille M,Burtscher M(2010).The prevalence of and risk factors for acute mountain sickness in the Eastern and Western Alps.High Alt Med Biol.11:343-348.
[10]Jackson SJ,Varley J,Sellers C,Josephs K,Codrington L,Duke G,Njelekela MA,Drummond G,Sutherland AI,Thompson AA,Baillie JK(2010).Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro.High Alt Med Biol.11:217-222.
[11]Ren Y,Fu Z,Shen W,Jiang P,He Y,Peng S,Wu Z,Cui B(2010).Incidence of high altitude illnesses among unacclimatized persons who acutely ascended to Tibet.High Alt Med Biol.11:39-42.
[12]Silva-Urra JA,Urizar C,Basualto-Alarcón C,Torrella JR,Pages T,Behn C,Viscor G(2011).Effects of oxygen supplementation on acute mountain sickness symptoms and functional capacity during a 2-kilometer walk test on Chajnantor plateau(5050 meters,Northern Chile).Wilderness Environ Med.22:250-256.
[13]Gertsch JH,Lipman GS,Hoick PS,Merritt A,Mulcahy A,Fisher RS,Basnyat B,Allison E,Hanzelka K,Hazan A,Meyers Z,Odegaard J,Pook B,Thompson M,Slomovic B,Wahlberg H,Wilshaw V,Weiss EA,Zafren K(2010).Prospective,double-blind,randomized,placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache:the Headache Evaluation at Altitude Trial(HEAT).Wilderness Environ Med.21:236-243.
[14]Anderson PJ,Miller AD,OMalley KA,Ceridon ML,Beck KC,Wood CM,Wiste HJ,Mueller JJ,Johnson JB,Johnson BD(2011).Incidence and Symptoms of High Altitude Illness in South Pole Workers:Antarctic Study of Altitude Physiology(ASAP).Clin Med Insights Circ Respir Pulm Med.5:27-35.
[15]Richalet JP,Larmignat P,Poitrine E,Letournel M,Canou?-Poitrine F(2012).Physiological risk factors for severe highaltitude illness:a prospective cohort study.Am J Respir Crit Care Med.185:192-198.
[16]Imray CH,Kennedy CH,Pattinson K,Brearey S,Wright A;Brimingham Medical Research Expeditionary Society(2004).Self-assessment of acute mountain sickness in adolescents:a pilot study.Wilderness Environ Med.15:202-206.
[17]Karinen HM,Peltonen JE,Khnen M,Tikkanen HO(2010).Prediction of acute mountain sickness by monitoring arterial oxygen saturation during ascent.High Alt Med Biol.11;325-332.
[18]Croughs M,Van Compel A,Van den Ende J(2011).Acute mountain sickness in travelers who consulted a pre-travel clinic.J Travel Med.18:337-343.
[19]Li X,Tao F,You H,Pei T,Gao Y.Factors Associated With Acute Mountain Sickness in Young Chinese Men on Entering Highland Areas.Asia Pac J Public Health.2011 Dec 23.[Epub ahead of print]