Glial control of depressive-like behaviors
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- 英文论文题名：Glial control of depressive-like behaviors
- 论文作者：高天明
- 英文论文作者：Tian-Ming Gao ; Department of Neurobiology ; School of Basic Medical Sciences ; Southern Medical University
- 年：2014
- 作者机构：Department of Neurobiology,School of Basic Medical Sciences,Southern Medical University;
- 会议召开时间：2014-12-19
- 会议录名称：广东省遗传学会第九届代表大会暨学术研讨会论文及摘要汇编
- 英文会议录名称：Theses and Abstracts Compilation of 9th Conference on Genetics,Guangdong
- 语种：英文
- 分类号：R749.4
- 学会代码：GDKL
- 会议名称：广东省遗传学会第九届代表大会暨学术研讨会
- 会议地点：中国广东广州
- 主办单位：广东省遗传学会
- 学会名称：广东省科学技术协会科技交流部
- 页数：1
- 文件大小：32k
- 原文格式：O
- 会议级别：地方
摘要
Major depressive disorder(MDD) is a cause of disability that affects approximately 16%of the world's population,but little is known about the underlying biology.Evidence from animal,postmortem brain and imaging studies of depressed patients has implicated glial dysfunction in MDD pathophysiology.However,the molecular mechanism through which astrocytes modulate depressive behaviors is largely unknown.Here,we identified adenosine 5'-triphosphate(ATP) as a key factor involved in astrocyte modulation of depressive behavior expression in adult mice.ATP is deficient in the brains of mice after social defeated,and ATP administration produced a rapid antidepressant(AD)-like effect.Both a lack of IP3R2 and transgenic blockage of vesicular gliotransmission caused a deficiency of astrocytic ATP release,which produced depressive-like behaviors that were rescued by ATP administration.Furthermore,genetically stimulating endogenous ATP release from astrocytes produced AD-like effects in a mouse model of depression.These results highlight astrocytic ATP release as a biological mechanism of MDD.
Major depressive disorder(MDD) is a cause of disability that affects approximately 16%of the world's population,but little is known about the underlying biology.Evidence from animal,postmortem brain and imaging studies of depressed patients has implicated glial dysfunction in MDD pathophysiology.However,the molecular mechanism through which astrocytes modulate depressive behaviors is largely unknown.Here,we identified adenosine 5'-triphosphate(ATP) as a key factor involved in astrocyte modulation of depressive behavior expression in adult mice.ATP is deficient in the brains of mice after social defeated,and ATP administration produced a rapid antidepressant(AD)-like effect.Both a lack of IP3R2 and transgenic blockage of vesicular gliotransmission caused a deficiency of astrocytic ATP release,which produced depressive-like behaviors that were rescued by ATP administration.Furthermore,genetically stimulating endogenous ATP release from astrocytes produced AD-like effects in a mouse model of depression.These results highlight astrocytic ATP release as a biological mechanism of MDD.
Major depressive disorder(MDD) is a cause of disability that affects approximately 16%of the world's population,but little is known about the underlying biology.Evidence from animal,postmortem brain and imaging studies of depressed patients has implicated glial dysfunction in MDD pathophysiology.However,the molecular mechanism through which astrocytes modulate depressive behaviors is largely unknown.Here,we identified adenosine 5'-triphosphate(ATP) as a key factor involved in astrocyte modulation of depressive behavior expression in adult mice.ATP is deficient in the brains of mice after social defeated,and ATP administration produced a rapid antidepressant(AD)-like effect.Both a lack of IP3R2 and transgenic blockage of vesicular gliotransmission caused a deficiency of astrocytic ATP release,which produced depressive-like behaviors that were rescued by ATP administration.Furthermore,genetically stimulating endogenous ATP release from astrocytes produced AD-like effects in a mouse model of depression.These results highlight astrocytic ATP release as a biological mechanism of MDD.
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