紧密连接蛋白及其对断奶仔猪肠道健康的影响
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摘要
紧密连接蛋白是肠道黏膜屏障的重要组成部分。本文系统综述了紧密连接蛋白的结构、紧密连接蛋白对仔猪肠道健康的影响,以及总结了断奶应激、肠道微生物、饲料抗原和霉菌毒素、生物活性物质等因素对仔猪肠道紧密连接蛋白的影响。
引文
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[42]李宝,李煜,马良友,等.大豆抗原蛋白对断奶仔猪细胞因子及肠上皮紧密连接蛋白Claudin-1 mRNA表达的影响.中国畜牧兽医,2015,5:1511-1517.
[43]韩蕊,赵元,潘丽,等.大豆球蛋白对仔猪小肠上皮细胞Occludin mRNA表达的影响.畜牧兽医学报,2013,44:1258-1262.
[44]Zhao Y,Qin G,Han R,et al..beta-Conglycinin reduces the tight junction occludin and ZO-1 expression in IPECJ2.Int J Mol Sci,2014,15:1915-1926.
[45]刘丹丹.β-伴大豆球蛋白及其酶解肽对仔猪空肠上皮细胞机械屏障功能损伤的比较研究.吉林农业大学2015.
[46]潘丽.大豆凝集素对仔猪肠上皮细胞机械屏障功能的影响.吉林农业大学,2014.
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[51]Pinton P,Nougayrede J P,Del Rio J C,et al..The food contaminant deoxynivalenol,decreases intestinal barrier permeability and reduces claudin expression.Toxicol Appl Pharmacol,2009,237:41-48.
[52]Pinton P,Tsybulskyy D,Lucioli J,et al..Toxicity of deoxynivalenol and its acetylated derivatives on the intestine:differential effects on morphology,barrier function,tight junction proteins,and mitogen-activated protein kinases.Toxicol Sci,2012,130:180-190.
[53]Awad W A,Aschenbach J R,Zentek J.Cytotoxicity and metabolic stress induced by deoxynivalenol in the porcine intestinal IPEC-J2 cell line.J Anim Physiol Anim Nutr(Berl),2012,96:709-716.
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[55]De Walle J V,Sergent T,Piront N,et al..Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis.Toxicol Appl Pharmacol,2010,245:291-298.
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[2]Forster C.Tight junctions and the modulation of barrier function in disease.Histochem Cell Biol,2008,130:55-70.
[3]Garrod D,Chidgey M.Desmosome structure,composition and function.Biochim Biophys Acta,2008,1778:572-587.
[4]Ulluwishewa D,Anderson R C,Mcnabb W C,et al..Regulation of tight junction permeability by intestinal bacteria and dietary components.JNutr,2011,141:769-776.
[5]Groschwitz K R,Hogan S P.Intestinal barrier function:molecular regulation and disease pathogenesis.J Allergy Clin Immunol,2009,124:3-20)quiz 21-22.
[6]Lee S H.Intestinal permeability regulation by tight junction:implication on inflammatory bowel diseases.Intest Res,2015,13:11-18.
[7]Ma T Y.Intestinal epithelial barrier dysfunction in Crohn's disease.Proc Soc Exp Biol Med,1997,214:318-327.
[8]张影超,王希彪,崔世泉,等.肠上皮紧密连接蛋白mRNA的表达与仔猪断奶腹泻关系的研究.中国畜牧兽医,2014,41:221-224.
[9]夏天.紧密连接蛋白Claudin-1在大肠杆菌性腹泻仔猪胃肠道组织中的表达及意义.华中农业大学,2010.
[10]Turner J R.Intestinal mucosal barrier function in health and disease.Nat Rev Immunol,2009,9:799-809.
[11]Clayburgh D R,Musch M W,Leitges M,et al..Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo.J Clin Invest,2006,116:2682-2694.
[12]Matter K,Aijaz S,Tsapara A,et al..Mammalian tight junctions in the regulation of epithelial differentiation and proliferation.Curr Opin Cell Biol,2005,17:453-458.
[13]Balda M S,Garrett M D,Matter K.The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density.The Journal of Cell Biology,2003,160:423-432.
[14]Blikslager A.Mucosal epithelial barrier repair to maintain pig health.Livestock Science,2010,133:194-199.
[15]Cohen L,Sekler I,Hershfinkel M.The zinc sensing receptor,ZnR/GPR39,controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon.Cell Death&Disease,2014,5:e1307.
[16]Zhu C,L V H,Chen Z,et al..Dietary Zinc Oxide Modulates Antioxidant Capacity,Small Intestine Development,and Jejunal Gene Expression in Weaned Piglets.Biol Trace Elem Res,2016.
[17]Zhang B,Guo Y.Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1(ZO-1)expression in weaning piglets.Br J Nutr,2009,102:687-693.
[18]Spreeuwenberg M A,Verdonk J M,Gaskins H R,et al..Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning.J Nutr,2001,131:1520-1527.
[19]栾兆双.断奶应激对仔猪肠上皮细胞紧密连接和p38MAPK的影响.浙江大学,2013.
[20]Wijtten P J,Van Der Meulen J,Verstegen M W.Intestinal barrier function and absorption in pigs after weaning:a review.Br J Nutr,2011,105:967-981.
[21]Smith F,Clark J E,Overman B L,et al..Early weaning stress impairs development of mucosal barrier function in the porcine intestine.Am J Physiol Gastrointest Liver Physiol,2010,298:G352-363.
[22]刘海萍,胡彩虹,徐勇.早期断奶对仔猪肠通透性和肠上皮紧密连接蛋白Occludin mRNA表达的影响.动物营养学报,2008,20:442-446.
[23]Hu C H,Xiao K,Luan Z S,et al..Early weaning increases intestinal permeability,alters expression of cytokine and tight junction proteins,and activates mitogen-activated protein kinases in pigs.J Anim Sci,2013,91:1094-1101.
[24]Wang H,Zhang C,Wu G,et al..Glutamine enhances tight junction protein expression and modulates corticotropin-releasing factor signaling in the jejunum of weanling piglets.J Nutr,2015,145:25-31.
[25]Pie S,Lalles J P,Blazy F,et al..Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets.J Nutr,2004,134:641-647.
[26]Al-sadi R,Boivin M,Ma T.Mechanism of cytokine modulation of epithelial tight junction barrier.Front Biosci(Landmark Ed),2009,14:2765-2778.
[27]崔巍,刘冬妍,马力,等.TNF-α对肠上皮细胞紧密连接蛋白表达的作用.世界华人消化杂志,2007,15:1788-1793.
[28]Ma T Y,Iwamoto Gk,Hoa N T,et al..TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation.Am J Physiol Gastrointest Liver Physiol,2004,286:G367-376.
[29]Bruewer M,Luegering A,Kucharzik T,et al..Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.J Immunol,2003,171:6164-6172.
[30]Wells J M,Rossi O,Meijerink M,et al..Epithelial crosstalk at the microbiota-mucosal interface.Proc Natl Acad Sci U S A,2011,108 Suppl 1:4607-4614.
[31]Ohland C L,Macnaughton W K.Probiotic bacteria and intestinal epithelial barrier function.Am J Physiol Gastrointest Liver Physiol,2010,298:G807-819.
[32]Anderson R C,Cookson A L,Mcnabb W C,et al..Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation.BMC Microbiol,2010,10:316.
[33]Wang H,Zhang W,Zuo L,et al..Bifidobacteria may be beneficial to intestinal microbiota and reduction of bacterial translocation in mice following ischaemia and reperfusion injury.Br J Nutr,2013,109:1990-1998.
[34]Yang K M,Jiang Z Y,Zheng C T,et al..Effect of Lactobacillus plantarum on diarrhea and intestinal barrier function of young piglets challenged with enterotoxigenic Escherichia coli K88.J Anim Sci,2014,92:1496-1503.
[35]Yang F,Wang A,Zeng X,et al..Lactobacillus reuteri 15007 modulates tight junction protein expression in IPECJ2 cells with LPS stimulation and in newborn piglets under normal conditions.BMC Microbiol,2015,15:32.
[36]Ma X,Fan Px,Li L S,et al..Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions.J Anim Sci,2012,90 Suppl 4:266-268.
[37]Peng L,Li Z R,Green R S,et al..Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers.J Nutr,2009,139:1619-1625.
[38]Peng L,He Z,Chen W,et al..Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier.Pediatr Res,2007,61:37-41.
[39]Qin H,Zhang Z,Hang X,et al..L.plantarum prevents enteroinvasive Escherichia coli-induced tight junction proteins changes in intestinal epithelial cells.BMC Microbiol,2009,9:63.
[40]Jung K,Eyerly B,Annamalai T,et al..Structural alteration of tight and adherens junctions in villous and crypt epithelium of the small and large intestine of conventional nursing piglets infected with porcine epidemic diarrhea virus.Vet Microbiol,2015,177:373-378.
[41]朱翠,蒋宗勇,郑春田,等.大豆抗原蛋白的组成和致敏作用机理.动物营养学报,2011,23:2053-2063.
[42]李宝,李煜,马良友,等.大豆抗原蛋白对断奶仔猪细胞因子及肠上皮紧密连接蛋白Claudin-1 mRNA表达的影响.中国畜牧兽医,2015,5:1511-1517.
[43]韩蕊,赵元,潘丽,等.大豆球蛋白对仔猪小肠上皮细胞Occludin mRNA表达的影响.畜牧兽医学报,2013,44:1258-1262.
[44]Zhao Y,Qin G,Han R,et al..beta-Conglycinin reduces the tight junction occludin and ZO-1 expression in IPECJ2.Int J Mol Sci,2014,15:1915-1926.
[45]刘丹丹.β-伴大豆球蛋白及其酶解肽对仔猪空肠上皮细胞机械屏障功能损伤的比较研究.吉林农业大学2015.
[46]潘丽.大豆凝集素对仔猪肠上皮细胞机械屏障功能的影响.吉林农业大学,2014.
[47]Zhao Y,Qin G,Sun Z,et al..Effects of soybean agglutinin on intestinal barrier permeability and tight junction protein expression in weaned piglets.Int J Mol Sci,2011,12:8502-8512.
[48]Pestka J J,Smolinski A T.Deoxynivalenol:toxicology and potential effects on humans.J Toxicol Environ Health B Crit Rev,2005,8:39-69.
[49]Lessard M,Savard C,Deschene K,et al..Impact of deoxynivalenol(DON)contaminated feed on intestinal integrity and immune response in swine.Food Chem Toxicol,2015,80:7-16.
[50]Pinton P,Braicu C,Nougayrede J P,et al..Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism.J Nutr,2010,140:1956-1962.
[51]Pinton P,Nougayrede J P,Del Rio J C,et al..The food contaminant deoxynivalenol,decreases intestinal barrier permeability and reduces claudin expression.Toxicol Appl Pharmacol,2009,237:41-48.
[52]Pinton P,Tsybulskyy D,Lucioli J,et al..Toxicity of deoxynivalenol and its acetylated derivatives on the intestine:differential effects on morphology,barrier function,tight junction proteins,and mitogen-activated protein kinases.Toxicol Sci,2012,130:180-190.
[53]Awad W A,Aschenbach J R,Zentek J.Cytotoxicity and metabolic stress induced by deoxynivalenol in the porcine intestinal IPEC-J2 cell line.J Anim Physiol Anim Nutr(Berl),2012,96:709-716.
[54]Pinton P,Oswald I P.Effect of deoxynivalenol and other Type B trichothecenes on the intestine:a review.Toxins(Basel),2014,6:1615-1643.
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