不同用药时间在抗生素联合调肠药物治疗菌群失调腹泻患者的应用及安全性研究
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- 论文作者：刘华 ; 周原吉 ; 王秀梅 ; 唐海艳 ; 夏云
- 年：2016
- 作者机构：中国人民解放军总医院;
- 论文关键词：抗生素 ; 止泻药物 ; 双歧杆菌三联活菌肠溶胶囊 ; 治疗效果 ; 药物安全性
- 英文论文关键词：Antibiotics ; Antidiarrheal drugs ; Bifidobacterium trivial enteric-coated capsules ; Therapeutic effect ; Drug safety
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R574
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：2
- 文件大小：1953k
- 原文格式：D
- 会议级别：全国
摘要
目的:观察抗生素注入后2h联合止泻药物在菌群失调腹泻患者中的临床治疗效果。方法:选取2016年1月-2016年7月医院神经内科收治的菌群失调腹泻患者18例,采用随机数字方法将患者分为对照组(n=9)和观察组(n=9)。对照组采用抗生素治疗,常规服药时间联合双歧杆菌三联活菌肠溶胶囊,观察组在注入抗生素2h后联合双歧杆菌三联活菌肠溶胶囊,比较2组临床疗效及药物安全性。结果:治疗15d,观察组疗效率为100.0%,显著高于对照组的88.89%(P<0.05);2组治疗前粪便中双歧杆菌、乳杆菌、肠杆菌及B/E值差异无统计学意义(P>0.05);观察组治疗后15d粪便中双歧杆菌、乳杆菌、肠杆菌及B/E值,显著高于对照组(P<0.05);观察组治疗后药物不良反应发生率为6.67%,显著低于对照组的20.0%(P<0.05)。结论:菌群失调腹泻患者在注入抗生素2h后联合双歧杆菌三联活菌肠溶胶囊止泻药物效果理想,更加有助于菌群定植生长,药物安全性较高,值得推广应用。
Objective: To observe the clinical efficacy of antidiarrheal drugs in patients with dysbacteriosis diarrhea after 2 h of antibiotic infusion. Methods: Eighteen patients withdysbacteriosis diarrhea were enrolled from September 2014 to July 2016. The patients were divided into control group(n = 9) and observation group(n = 9) by random number method. Thecontrol group was treated with antibiotics. In the observation group, the combination of bifidobacterium bifidum enteric- coated capsules was injected 2 h after antibiotic injection. The clinicalefficacy and drug safety of the two groups were compared. Results: The therapeutic effect was 100.0% in the observation group and 88.89% in the control group(P <0.05). There was no significantdifference in the bifidobacteria, lactobacilli, enterobacteria and B / E value between the two groups before treatment(P> 0.05). In the observation group, the incidence of Bifidobacterium, Lactobacillus, Enterobacteriaceae and B / E in feces was significantly higher than that in the control group at 15 days after treatment(P <0.05); the incidence of adverse drug reaction Was 6.67%, which was significantly lower than that of the control group(P <0.05). Conclusion: Bifidobacterium bifidum enteric- coated capsules can be used as an antidiarrheal drug in patients with floradysbacteriosis diarrhea after injecting antibiotics for 2 hours, which is more helpful to the growth of flora colonization and drug safety.
Objective: To observe the clinical efficacy of antidiarrheal drugs in patients with dysbacteriosis diarrhea after 2 h of antibiotic infusion. Methods: Eighteen patients withdysbacteriosis diarrhea were enrolled from September 2014 to July 2016. The patients were divided into control group(n = 9) and observation group(n = 9) by random number method. Thecontrol group was treated with antibiotics. In the observation group, the combination of bifidobacterium bifidum enteric- coated capsules was injected 2 h after antibiotic injection. The clinicalefficacy and drug safety of the two groups were compared. Results: The therapeutic effect was 100.0% in the observation group and 88.89% in the control group(P <0.05). There was no significantdifference in the bifidobacteria, lactobacilli, enterobacteria and B / E value between the two groups before treatment(P> 0.05). In the observation group, the incidence of Bifidobacterium, Lactobacillus, Enterobacteriaceae and B / E in feces was significantly higher than that in the control group at 15 days after treatment(P <0.05); the incidence of adverse drug reaction Was 6.67%, which was significantly lower than that of the control group(P <0.05). Conclusion: Bifidobacterium bifidum enteric- coated capsules can be used as an antidiarrheal drug in patients with floradysbacteriosis diarrhea after injecting antibiotics for 2 hours, which is more helpful to the growth of flora colonization and drug safety.
引文
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[13]范薇薇,夏国莲.双歧杆菌四联活菌片对ICU抗生素相关性腹泻患者细胞免疫功能的影响及疗效观察[J].中国微生态学杂志,2014,26(1):66-68.
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[15]李琳,李岩.整肠生联合常乐康治疗伴肠道菌群失调功能性腹泻的疗效观察[J].中国微生态学杂志,2014,26(3):284-289.
[16]张华玲,周赛男,蔡莹,等.超微七味白术散对菌群失调腹泻小鼠小肠黏膜的影响[J].中国微生态学杂志,2013,25(1):9-13.
[2]温燕,李小关,李家树.老年慢性阻塞性肺疾病急性加重患者肠黏膜屏障功能变化的临床研究[J].实用医学杂志,2013,29(16):2600-2603
[3]李晶,王垂杰,李玉锋,等.功能性腹泻脾虚证与肠黏膜屏障关系探讨[J].中国中西医结合消化杂志,2015,23(4):299-302
[4]谢炳林,官玉兰,李兆子.迁延性慢性腹泻的联合治疗疗效及对免疫调节的影响[J].中国处方药,2014,12(11):51-52
[5]Wang H,Zhang W,Zuo L,et al.Intestinal dysbacteriosis contributes to decreased intestinal mucosal barrier function and increased bacterial translocation[J].Letters in Applied Microbiology,2014,58(4):384-392
[6]吴蕾.双歧杆菌活菌联合蒙脱石治疗小儿腹泻的Meta分析[J].湖南师范大学学报(医学版),2014,11(1):93-96.
[7]黄文雅,陆付耳,董慧.肠道菌群失调与生物钟紊乱的相关性[J].中国病理生理杂志,2015,31(5):950-955.
[8]洪菁,郭芸,周桂兰,等.不同温度营养液对预防肠内营养相关性腹泻的影响[J].护理研究,2015,29(9):1135.
[9]肖春莲,徐丽丹,吴继红.益力多对COPD患者肠内营养相关性腹泻的预防与护理[J].中国当代医药,2013,20(17):139-140
[10]Bagchi A.K.,Sharma A.,Dhingra S.,Lehenbauer Ludke A.R.,Al-Shudiefat A.A.,Singal P.K.:Interleukin-10 activates Toll-like receptor 4 and requires My D88 for cardiomyocyte survival.Cytokine 2013,61(1):304-314.249
[11]王琳,翁峰霞,黄昉芳.危重症病人肠内营养支持治疗并发腹泻的护理[J].全科护理,2015,13(2):151-152.
[12]陈建军,陈兰平,邓义军.低蛋白泻症对危重患者肠内营养相关性腹泻的影响[J].医学综述,2015,21(5):929-931.
[13]范薇薇,夏国莲.双歧杆菌四联活菌片对ICU抗生素相关性腹泻患者细胞免疫功能的影响及疗效观察[J].中国微生态学杂志,2014,26(1):66-68.
[14]Grgurich P.E.,Hudcova J.,Lei Y.,Sarwar A.,Craven D.E.:Diagnosis of ventilatorassociated pneumonia:controversies and working toward a gold standard.Current opinion in infectious diseases 2013,26(2):140-150.165.
[15]李琳,李岩.整肠生联合常乐康治疗伴肠道菌群失调功能性腹泻的疗效观察[J].中国微生态学杂志,2014,26(3):284-289.
[16]张华玲,周赛男,蔡莹,等.超微七味白术散对菌群失调腹泻小鼠小肠黏膜的影响[J].中国微生态学杂志,2013,25(1):9-13.