羧基修饰的Fe_3O_4纳米颗粒表面蛋白印迹聚合物的制备
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摘要
<正>分子印迹技术具有成本低廉、高稳定性、易于表面化学修饰以及信号整合等特点,在医疗诊断、分离纯化、检测分析、催化、给药、生化传感器等多个领域备受关注1。目前,针对小分子的印迹研究已取得较好效果。然而对蛋白等于生物大分子的相关印迹研究中取得的进展有限。由于蛋白分子体积大、传质受限、水相中氢键受到水分子的干扰严重等,蛋白分子印迹研究目前仍面临巨大挑战2。
引文
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2 .Lv Y,Tan T.,Svec F.M olecular imp rinting of p roteins in p oly mers attached to the surface of nanomaterials for selective recognition of biomacromolecules,Biotechnology Advances,2013,31(8):1172-1186
3 .Zahedi P.,Ziaee M.,Abdouss M.,et al.,Biomacromolecule temp late-based molecularly imp rinted p oly mers with an emp hasis on their sy nthesis strategies:a review,Poly mers for Advanced Technologies,2016.
4 .Ou S,Wu M,Chou T,et al.,Poly acry lamide gels with electrostatic functional group s for the molecular imp rinting of ly sozy me,Analy tica Chimica Acta,2004,504(1):163–166