公石松水提液对小鼠运动能力与血清乳酸、尿素氮及肝糖原的影响

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• 英文论文题名：Effects of aqueous extract of Ludisia discolor on locomotory capacity,the serum concentrations of lactic acid and urea nitrogen,hepatic glycogen in mice
• 论文作者：石鹤坤 ; 陈开杰 ; 林小凤 ; 陈锦珊
• 英文论文作者：SHI Hekun ; CHEN Kaijei ; LIN Xiaofeng ; CHEN Jinsan ; Department of Pharmacy ; 175 Hospital of PLA/Affiliated Southeast Hospital of Xiamen University
• 年：2016
• 作者机构：解放军175医院/厦门大学附属东南医院药学科;
• 论文关键词：公石松水提液 ; 运动性疲劳 ; 肝糖原 ; 血乳酸 ; 血尿素氮
• 英文论文关键词：aqueous extract of Ludisia discolor ; sports fatigue ; hepatic glycogen ; blood lactic acid ; blood urea nitrogen
• 会议召开时间：2016-09-27
• 会议录名称：中国药学会第十三届青年药学科研成果交流会论文集
• 语种：中文
• 分类号：R285.5
• 学会代码：YYWS
• 会议名称：中国药学会第十三届青年药学科研成果交流会
• 会议地点：中国江西南昌
• 主办单位：中国药学会
• 学会名称：中国药学会
• 页数：4
• 文件大小：282k
• 原文格式：O
• 会议级别：全国

摘要

目的:探讨公石松水提液对抗小鼠运动性疲劳的作用及其机理。方法:雄性小鼠随机分为5组:公石松水提液低、中、高剂量组[分别用公石松1.22、2.44、4.88g/(kg·d)]、阳性对照组[红景天水提物2.34g/(kg·d)]和空白对照组(等量蒸馏水),连续灌胃7d后,测定小鼠负重游泳时间及游泳90min后血乳酸、血尿素氮及肝糖原指标。结果:公石松水提液各组均可显著降低小鼠血尿素氮水平(P<0.05),增加肝糖原含量(P<0.05),呈量效关系;公石松水提液高剂量组可降低血乳酸,延长小鼠负重游泳时间(P<0.05)。其作用与阳性对照红景天水提物相当。结论:公石松水提液具有抗小鼠运动性疲劳作用,其作用机理可能通过提高肝糖原储备、增加葡萄糖的有氧分解、减少葡萄糖的无氧酵解、减少蛋白质的分解有关。
Objective To investigate the agonistic sports fatigue effect of the Ludisia discolor in mice.Methods Male mice were randomly divided into 5 groups included low-,middle-,high-dose groups(aqueous extract of Ludisia discolor at dose of1.22,2.44,4.88 g/kg·d),positive control group(aqueous extract of Rhodiola,at dose of 2.34g/kg·d) and control group(distilled water).All the groups were treated by lavage for continuous 7 days,then measured weight loading swimming time,blood urea nitrogen,blood lactic acid and hepatic glycogen levels after swimming 90 min.Results The contents of blood urea nitrogen was decreasing(P<0.05) in aqueous extract of Ludisia discolor groups,and the content of hepatic glycogen was increasing(P<0.05) in a dose-dependent manner.The blood lactic acid was significantly decreased in high-dose group,weight loading swimming time was extended in mice.The effects of Ludisia discolor is similar with Rhodiola.Conclusion The aqueous extract of Ludisia discolor could resist fatigue in mice.The mechanism might be related with the increasing glycogen reserves and glucose aerobic decomposition as well as the reducing anaerobic glucose solution and decomposition of proteins.

引文

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