高效双光子激发可降解的交替共聚物自组装纳米聚集体
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- 英文论文题名：O-nitrobenzyl-alt-(phenylethynyl)benzene copolymer-based nanoaggregates with highly efficient two-photon-triggered degradable property
- 论文作者：赵惠 ; 侯冰 ; 胡文博 ; 范曲立 ; 黄维
- 英文论文作者：Hui Zhao ; Bing Hou ; Wenbo Hu ; Quli Fan ; Wei Huang ; Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) ; Nanjing University of Posts & Telecommunications ; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) ; Nanjing Tech University (Nanjing Tech)
- 年：2016
- 作者机构：南京邮电大学先进材料与纳米技术研究院;南京工业大学柔性电子与先进材料研究院;
- 论文关键词：近红外激发 ; 光降解 ; 双光子吸收 ; 纳米聚集体
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十八分会：化学生物学
- 语种：中文
- 分类号：TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十八分会 ; 化学生物学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：120k
- 原文格式：D
- 会议级别：全国
摘要
近年来,双亲性纳米载药系统在药物运输和释放中受到广泛应用。在环境刺激响应下实现可控释放是实现治疗过程中减少副作用的关键因素。在各种刺激激发降解的体系中,光降解有其独特的优势,因为它是一种外部光源,能够实现无触点模式和对体系的精确控制。目前的光降解纳米载药系统的主要缺点在于大部分的光敏基团都是紫外或可见光敏感的,有些具有双光子吸收性质的光敏基团由于吸收截面太小导致降解效率很低。有课题组将光敏基团结合上转换纳米粒子通过能量转移实现近红外光激发降解,然而无机纳米粒子存在潜在的毒性,所以我们提出将具有大的双光子吸收截面的苯炔苯材料和光敏基团硝基苄基结合,交替出现作为聚合物主链,通过能量转移实现近红外激发降解,一方面解决了近红外光激发的问题,另一方面克服了光敏集团本身双光子吸收截面小的问题。在侧链引入PEG链,通过自组装成纳米聚集体,用于负载疏水性的药物,并且实现近红外激发下的可控释放。
Light-controlled drag delivery systems constituted an appealing means to realize drug release spatiotemporally at the site of interest with high specificity.However,the utilization of light-activatable systems was hindered by the lack of suitable drag carriers that respond to near infrared light.Here,we reported a two-photon-triggered degradable amphiphilic copolymer in which photo-cleavable species o-nitrobenzyl(ONB) was positioned alternately into the backbone of(phenylethynyl)benzene(PEB) based polymer.Further,hydrophilic polyethylene glycol was grafted to the side chain of copolymer to obtain amphiphilic structure,which could self-assemble into nanoaggregates(NAs).In this structure,PEB fluorophore with relatively good two-photon absorption(TPA)cross-section performed a fluorescent resonance energy transfer(FRET) to ONB under 800 nm irradiation for two-photon-triggered photolysis.The aggregation state of copolymer NAs provided large TPA cross-section and effective intermolecular/intramolecular FRET between PEB and ONB,which was beneficial for improving degradation efficiency.
Light-controlled drag delivery systems constituted an appealing means to realize drug release spatiotemporally at the site of interest with high specificity.However,the utilization of light-activatable systems was hindered by the lack of suitable drag carriers that respond to near infrared light.Here,we reported a two-photon-triggered degradable amphiphilic copolymer in which photo-cleavable species o-nitrobenzyl(ONB) was positioned alternately into the backbone of(phenylethynyl)benzene(PEB) based polymer.Further,hydrophilic polyethylene glycol was grafted to the side chain of copolymer to obtain amphiphilic structure,which could self-assemble into nanoaggregates(NAs).In this structure,PEB fluorophore with relatively good two-photon absorption(TPA)cross-section performed a fluorescent resonance energy transfer(FRET) to ONB under 800 nm irradiation for two-photon-triggered photolysis.The aggregation state of copolymer NAs provided large TPA cross-section and effective intermolecular/intramolecular FRET between PEB and ONB,which was beneficial for improving degradation efficiency.
引文
[1]J.Nicolas,S.Mura,D,Brambilla,N.Mackiewicz,P.Couvreur,Chem Soc Rev 2013,42,1147
[2]L.Feng,C.Zhu,H.Yuan,L.Liu,F.Lv,S.Wang,Chem Soc Rev 2013,42,6620-6633
[2]L.Feng,C.Zhu,H.Yuan,L.Liu,F.Lv,S.Wang,Chem Soc Rev 2013,42,6620-6633