自调控按需释放的抗菌水凝胶
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- 英文论文题名：Antibacterial gel with self-regulated on demand release
- 论文作者：胡婧婧 ; 全艳春 ; 胡志琦 ; 程义云
- 英文论文作者：Jingjing Hu ; Yanchun Quan ; Zhiqi Hu ; Yiyun Cheng ; School of Life Sciences ; East China Normal University ; Department of Orthopedic Oncology ; Changzheng Hospital ; the Second Military Medical University
- 年：2016
- 作者机构：华东师范大学;第二军医大学附属长征医院;
- 论文关键词：自调节释放 ; 按需治疗 ; 抗菌胶
- 英文论文关键词：self regulated release ; on demand delivery ; antibacterial hydrogel
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：O648.17
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：2
- 文件大小：283k
- 原文格式：D
- 会议级别：全国
摘要
细菌感染会引起多种疾病,严重可造成死亡,已成为医学上一项棘手难题。1928年青霉素的使用拯救了上百万患者,从此奠定了抗生素药物在细菌治疗中不可替代的地位。然而,抗生素的临床使用通常会由于其抗药性受到限制,主要由医疗知识的缺乏导致抗生素滥用以及传统的用药方式所造成,比如传统的静脉注射以及口服会由于系统循环使到达感染病灶部位的药物浓度不足以杀灭细菌[1]。近年来,相关研究者们提出通过局部给药来提高感染部位的药物浓度,同时减少对正常组织的毒副作用。通常将抗生素药物包裹在凝胶中来进行局部给药,然而这种包裹装载的抗生素多是通过物理扩散进行释放,释放速率以及时间无法控制,常会出现初期的药物爆释以及随后药物浓度的骤降[2],同样会导致治疗效果欠佳。为了更好的对抗生素药物进行"按需"使用,提高其使用效率并减少耐药性形成,本研究中将采取含有多个氨基的抗生素药物本身作为交联剂,通过具有酸性可断裂的席夫碱键与多糖高分子交联成胶,只有当细菌感染产生酸时,凝胶才会降解并释放药物,从而实现"按需"治疗。该抗生素凝胶可有效抑制并杀死多种细菌,并且可通过调节凝胶的含药量来控制药物的释放速率,可适应多种临床需求。
Antibiotic has occupied an irreplaceable position in bacterial disease treatment, while antimicrobial resistance has seriously limited the clinical use. This is often caused by the abuse of antibiotics and its traditional administration, which may lead to insufficient antibiotic concentration due to limited blood perfusion. Recently, local administration has been developed to expect for a constant plasma concentration of antibiotic at the lesion. While it is mostly performed by direct encapsulation of antibiotic in the depot, which usually exhibit an initial burst and followed sub-inhibitory concentration, still can't meet the particular demand for suitable time and amount of drug needed. To obtain the on-demand delivery of antibiotic, we have employed the antibiotics with several amine groups as the linker to cross-link with the polysaccharides through acid cleavable Schiff base. The antibiotics will be only released in the presence of bacteria which may generate acid to degrade the hydrogel, achieve the on-demand therapy. Besides, the antibiotic gel has a wide inhibitory spectrum of bacteria, and the release rate can be controlled by adjusting the drug contents.
Antibiotic has occupied an irreplaceable position in bacterial disease treatment, while antimicrobial resistance has seriously limited the clinical use. This is often caused by the abuse of antibiotics and its traditional administration, which may lead to insufficient antibiotic concentration due to limited blood perfusion. Recently, local administration has been developed to expect for a constant plasma concentration of antibiotic at the lesion. While it is mostly performed by direct encapsulation of antibiotic in the depot, which usually exhibit an initial burst and followed sub-inhibitory concentration, still can't meet the particular demand for suitable time and amount of drug needed. To obtain the on-demand delivery of antibiotic, we have employed the antibiotics with several amine groups as the linker to cross-link with the polysaccharides through acid cleavable Schiff base. The antibiotics will be only released in the presence of bacteria which may generate acid to degrade the hydrogel, achieve the on-demand therapy. Besides, the antibiotic gel has a wide inhibitory spectrum of bacteria, and the release rate can be controlled by adjusting the drug contents.
引文
[1]Gao,P.;Nie,X.;Zou,M.;Shi,Y.;Cheng G.J.Antibiot.2011,64:625.
[2]Campoccia,D.;Montanaro,L.;Speziale,P.;Arciola,C.R.Biomaterials 2011,64:625.
[2]Campoccia,D.;Montanaro,L.;Speziale,P.;Arciola,C.R.Biomaterials 2011,64:625.