纸喷雾-离子迁移谱快速检测次乌头碱的研究
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- 英文论文题名：Preliminary Studies on Rapid Detection of Hypaconitine with Paper Spray-Ion Mobility Spectrometer
- 论文作者：孔景临 ; 陈创 ; 刘卫卫 ; 秦墨林 ; 李宝强 ; 李海洋
- 英文论文作者：Kong Jinglin ; Chen Chuang ; Liu Weiwei ; Qin Molin ; Li Baoqiang ; Li Haiyang ; Research Institute of Chemical Defense ; Dalian Institute of Chemical Physics ; Chinese Academy of Sciences
- 年：2016
- 作者机构：防化研究院;中科院大连化学物理研究所;
- 论文关键词：纸喷雾 ; 离子迁移谱 ; 次乌头碱
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十四分会：公共安全化学
- 语种：中文
- 分类号：O657;D918.93
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十四分会 ; 公共安全化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：234k
- 原文格式：D
- 会议级别：全国
摘要
生物碱是多种中草药的有效成分。一些生物碱如剧毒类的乌头碱类化合物常有因不当治疗、误食、蓄意投毒等导致中毒的案例报道。因此建立灵敏可靠的痕量生物碱快速检测方法,对于天然产物化学、制药、食品安全、司法物证鉴定等领域的研究具有重要意义。现有生物碱的检测方法主要包括高效液相色谱法(HPLC)、气质联用(GC-MS)以及液质联用(LC-MS)等~([1]),这些方法均需使用大型实验室设备,不适用于现场快速检测。纸喷雾作为一种敞开式常压电离方式,因其具有免除样品等前处理过程,可直接分析等优点成为当前快速检测领域的研究热点~([2-3])。本研究将纸喷雾与离子迁移谱联用,自行搭建了纸喷雾离子迁移谱实验平台(图1),以次乌头碱为研究对象,建立相关检测方法,从滴加溶剂到获得结果的时间在60 s内(图2),具有发展为生物碱等高活性物质现场快速检测方法的潜力。
Paper spray(PS) which is one kind of an ambient ionization sources has been developed to allow fast analysis of raw samples by mass spectrometry with not much or no sample preparation in recent years. A paper spray ionization-ion mobility spectrometer(PSI-IMS) was implemented in this report. The method for detecting hypaconitine was established with this PSI-IMS platform. Data shown herein indicate that paper spray ambient ionization can be readily used as a rapid and robust method for in situ direct analysis of active components such as alkaloids in natural products.
Paper spray(PS) which is one kind of an ambient ionization sources has been developed to allow fast analysis of raw samples by mass spectrometry with not much or no sample preparation in recent years. A paper spray ionization-ion mobility spectrometer(PSI-IMS) was implemented in this report. The method for detecting hypaconitine was established with this PSI-IMS platform. Data shown herein indicate that paper spray ambient ionization can be readily used as a rapid and robust method for in situ direct analysis of active components such as alkaloids in natural products.
引文
[1]熊小婷,吴惠勤,黄晓兰,分析化学,2009,37(10):1433-1438
[2]Yue Ren,He Wang,Jiangjiang Liu,Zhiping Zhang,Chromatographia,2013,76:1339–1346
[3]Ouyang Z,Zhang XR.Analyst,2010,135(4):659–660
[2]Yue Ren,He Wang,Jiangjiang Liu,Zhiping Zhang,Chromatographia,2013,76:1339–1346
[3]Ouyang Z,Zhang XR.Analyst,2010,135(4):659–660