表面原子转移自由基聚合构建甜菜碱两性离子聚合物生物活性涂层
详细信息 查看官网全文
- 英文论文题名：Construction of zwitterionic copolymer bioactive brush via si-ATRP
- 论文作者：魏雨 ; 张景迅 ; 杨炫煌 ; 刘冬寅 ; 赵洁
- 英文论文作者：Yu Wei ; Jingxun Zhang ; Xuanhuang Yang ; Dongyin Liu ; Jie Zhao ; Department of Chemistry and chemical engineering ; Huanghuai University
- 年：2016
- 作者机构：黄淮学院化学化工系;
- 论文关键词：表面原子转移自由基聚合 ; 两性离子聚合物 ; 甲基丙烯酸缩水甘油酯 ; 多肽
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：O631.5;TB306
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：144k
- 原文格式：D
- 会议级别：全国
摘要
表面引发原子转移自由基聚合具有合成分子量可控、分子量分布窄以及实施条件比较温和等优点,是一种很好的制备聚合物刷的方法~([1])。两性离子聚合物是指聚合物链中含有两性离子基团的聚合物,包括磷酰胆碱(PC)~([2])、磺酸甜菜碱(SBMA)~([3])和羧酸甜菜碱(CBMA)~([4])等。这类聚合物在静电力诱导下,基团表面可以形成水化层,从而阻抗非特异性蛋白质吸附、细菌粘附等,广泛应用于生物医用材料领域。甲基丙烯酸缩水甘油酯(GMA)是一种含有大量环氧基团的单体,这些环氧基团可在常温条件下与蛋白质大分子链上的多种基团(氨基、巯基、酚羟基等)发生反应,形成稳定的共价键,因此广泛用于生物活性分子的固定~([5])。本研究通过表面原子转移自由基聚合方法在硅片表面构建了CBMA-GMA共聚物刷,并通过GMA中丰富的环氧基团开环固定内皮细胞选择性多肽REDV,制备具有内皮细胞选择性的功能界面。
Surface initiated atom transfer radical polymerization exhibits many advantages such as controllable molecular weight,narrow molecular weight distribution which is a good way to prepare the polymer brush.Carboxybetaine methacrylate ester(CBMA) contains zwitterionic groups.In electrostatic induction,surface hydration layer may be formed which can resist nonspecific protein adsorption and bacterial adhesion.Glycidyl methacrylate(GMA)contains a lot of epoxy group which could react with amino groups by ring-opening reaction under normal conditions.It is widely used for fixing a biologically active molecule.In this study,CBMA-GMA copolymer brush was constructed via si-ATRP on wafer surface,and then REDV peptide was covalent grafted onto surface by ring opening reaction of GMA.Then the endothelial selective interface was constructed.
Surface initiated atom transfer radical polymerization exhibits many advantages such as controllable molecular weight,narrow molecular weight distribution which is a good way to prepare the polymer brush.Carboxybetaine methacrylate ester(CBMA) contains zwitterionic groups.In electrostatic induction,surface hydration layer may be formed which can resist nonspecific protein adsorption and bacterial adhesion.Glycidyl methacrylate(GMA)contains a lot of epoxy group which could react with amino groups by ring-opening reaction under normal conditions.It is widely used for fixing a biologically active molecule.In this study,CBMA-GMA copolymer brush was constructed via si-ATRP on wafer surface,and then REDV peptide was covalent grafted onto surface by ring opening reaction of GMA.Then the endothelial selective interface was constructed.
引文
[1]Husseman,M.;Malmstrom,E.;Monamara,M.et al.Macromolecules.1999,32(5):1424.
[2]Hasegawa,T.;Iwasaki,Y.;Ishihara,K.JBMR-A.2002,63(3):333.
[3]Carr,L.;Cheng,G.;Xue,H.et al.Langmuir.2010,26(18):14793.
[4]Carr,L.;Xue,H.;Jiang,S.Biomaterials.2011,32(4):961.
[5]Chae,K.;Jang.Y.;Kim,Y.et al.Sensors and Actuators B.2007,124(1):153.
[2]Hasegawa,T.;Iwasaki,Y.;Ishihara,K.JBMR-A.2002,63(3):333.
[3]Carr,L.;Cheng,G.;Xue,H.et al.Langmuir.2010,26(18):14793.
[4]Carr,L.;Xue,H.;Jiang,S.Biomaterials.2011,32(4):961.
[5]Chae,K.;Jang.Y.;Kim,Y.et al.Sensors and Actuators B.2007,124(1):153.