近红外响应纳米材料在肿瘤影像示踪与诊疗一体化中的应用研究
详细信息 查看官网全文
- 英文论文题名：Design and Preparation of NIR-responsive Nanocomposites as Nanomedicines for Cancer Phototherapy
- 论文作者：晏亮 ; 谷战军 ; 赵宇亮
- 英文论文作者：Liang Yan ; Zhanjun Gu ; Yuliang Zhao ; Institute of High Energy Physics ; Chinese Academy of Sciences ; National Center for Nanosciences and Technology of China
- 年：2016
- 作者机构：中科院高能物理研究所中科院纳米生物效应与安全性重点实验室;国家纳米中心;
- 论文关键词：纳米材料 ; 生物成像 ; 光热治疗 ; 诊疗一体化
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：R73-3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：243k
- 原文格式：D
- 会议级别：全国
摘要
癌症是威胁人类生命的一种重大疾病。目前,癌症的治疗方法主要有化疗、放疗和手术治疗,但是这些治疗手段在临床使用中遇到许多困难,使得癌症的临床治疗效果并不理想。然而,纳米技术的快速发展为癌症诊疗带来了新的希望。近红外响应纳米粒子因其具有尺寸较小、光热转换效率高以及X-射线吸收能力强等特点在癌症探测、诊断和治疗领域有广泛应用。我们通过优化近红外响应纳米材料构建稳定、高效和安全的纳米载体,并将化疗、光动力学治疗等治疗方式相结合,发展整合靶向、活体示踪、光热治疗、药物治疗和预后检测等功能于一体的诊断治疗纳米药物。我们的结果表明,近红外响应纳米材料具有良好的生物相容性,其自身可作为优良的光声成像造影剂、CT造影剂以及光热试剂;同时利用其两亲的表面负载抗肿瘤药物或者光敏剂,可以实现药物的可控缓释。这将为有效地提高纳米药物呈递效率和减轻药物毒副作用提供强有力的支持。
Cancer is one of the greatest killers and threats to human life in the worldwide. Nowadays, as each treatment method such as chemotherapy has its drawbacacks, cancer therapy still doesn't reach an optimal result. However, the rapid development of nanotechnology brights about new opportunities for cancer diagnosis and therapeutics. Recently, due to the small size, high NIR absorption coefficient and X-ray attenuation capability, NIR-responsive nanomaterials have been used for cancer detection, diagnosis and treatment widely. Herein, we mainly focus on building stable, efficient and safe nanocarriers, ultimately fabricating theranostic agents integrating targeted therapy, in vivo tracing and prognosis monitoring into one system. Our results indicate that these theranostic agents possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging, while being developed as nanocarriers for NIR photothermal-triggered drug delivery. This simple but powerful theranostic nanomaterial shows a potential promise for precision nanomedicine paradigm.
Cancer is one of the greatest killers and threats to human life in the worldwide. Nowadays, as each treatment method such as chemotherapy has its drawbacacks, cancer therapy still doesn't reach an optimal result. However, the rapid development of nanotechnology brights about new opportunities for cancer diagnosis and therapeutics. Recently, due to the small size, high NIR absorption coefficient and X-ray attenuation capability, NIR-responsive nanomaterials have been used for cancer detection, diagnosis and treatment widely. Herein, we mainly focus on building stable, efficient and safe nanocarriers, ultimately fabricating theranostic agents integrating targeted therapy, in vivo tracing and prognosis monitoring into one system. Our results indicate that these theranostic agents possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging, while being developed as nanocarriers for NIR photothermal-triggered drug delivery. This simple but powerful theranostic nanomaterial shows a potential promise for precision nanomedicine paradigm.
引文
[1]Liu,J.,Zheng,X.,Yan,L.,Zhou,L.,Tian,G.,Yin,W.,Wang,L.,Liu,Y.,Hu,Z.,Gu,Z.,Chen,C.&Zhao,Y.ACS Nano 2015,9:696.
[2]Zheng,X.,Shi,J.,Bu,Y.,Tian,G.,Zhang,X.,Yin,W.,Gao,B.,Yang,Z.,Hu,Z.,Liu,X.,Yan,L.*,Gu,Z.&Zhao,Y.Nanoscale 2015,7:12581-12591.
[2]Zheng,X.,Shi,J.,Bu,Y.,Tian,G.,Zhang,X.,Yin,W.,Gao,B.,Yang,Z.,Hu,Z.,Liu,X.,Yan,L.*,Gu,Z.&Zhao,Y.Nanoscale 2015,7:12581-12591.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |