女性生殖系统原发性恶性黑色素瘤的诊断、治疗及预后分析

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• 英文论文题名：Diagnosis,treatment and prognosis of primary malignant melanoma of female genital system
• 论文作者：杨森梦 ; 梁志清 ; 徐惠成 ; 陈勇 ; 余美佳
• 英文论文作者：Yang Senmeng ; Liang Zhiqing ; Xu Huicheng ; Chen Yong ; Department of Obstetrics and Gynecology ; Langzhong Municipal People's Hospital ; Department of Obstetrics and Gynecology ; the First Affiliated Hospital of Third Military Medical University
• 年：2017
• 作者机构：四川省阆中市人民医院妇产科;第三军医大学第一附属医院妇产科;
• 论文关键词：女性生殖系统 ; 恶性黑色素瘤 ; 诊断 ; 治疗 ; 预后
• 英文论文关键词：female reproductive system ; malignant melanoma ; diagnosis ; treatment ; prognosis
• 会议召开时间：2017-05-26
• 会议录名称：2017年《中国组织化学与细胞化学杂志》临床研讨会论文集
• 语种：中文
• 分类号：R737.3
• 学会代码：ZHXB
• 会议名称：2017年《中国组织化学与细胞化学杂志》临床研讨会
• 会议地点：中国湖北武汉
• 主办单位：《中国组织化学与细胞化学杂志》社有限公司
• 学会名称：《中国组织化学与细胞化学杂志》社有限公司
• 页数：2
• 文件大小：251k
• 原文格式：O
• 会议级别：全国

摘要

目的:女性生殖系统原发恶性黑色素瘤(malignant melanoma,MM)罕见,通过对我院13例病例诊治分析,探讨其诊断、治疗及预后。方法:选取2005年-2015年10月期间收治的13例原发性恶性黑色素瘤患者临床资料进行回顾性分析。结果:本组病例平均年龄54岁,发生于60岁以上者占46.15%(6/13)。13例患者中手术治疗10例,采用其他方法治疗3例。随访至今,存活者仅5例:1例外阴恶性黑色素瘤患者术后7个月出现骨转移;1例外阴恶性黑色素瘤患者仅行化疗,4月后出现肝及右髂骨转移;1例阴道恶性黑色素瘤III期患者术后20个月病情平稳;1例阴道恶性黑色素瘤III期患者术后19月病情稳定;1例宫颈恶性黑色素瘤患者术后22月病情稳定。结论:女性恶性黑色素瘤预后不良。扩大的手术范围并不能改善患者生存率及生活质量。目前治疗仍以手术为主的综合治疗,结合放/化疗、生物治疗及靶向治疗等综合手段。
Objective:To study the diagnosis,treatment and prognosis of 13 cases of primary malignant melanoma(malignant melanoma) in female reproductive system(MM).Methods:the clinical data of 13 patients with primary malignant melanoma treated in our hospital from 2005 to October-2015 were analyzed retrospectively.Results:the average age of the patients was 54 years old,accounting for more than 60 years old(6/-46.15%)().13 cases were treated with surgery,and other Methods:were used in the treatment of 3 cases(n= 10).Up till now,only 1 survivors in 5 cases;vulvar melanoma patients after 7months of bone metastasis;1 cases of vulvar malignant melanoma patients only received chemotherapy after April,liver and right iliac bone metastasis;20 months of illness in 1 patients with malignant melanoma in the vagina after Ⅲ period smoothly;19 months of stable disease in 1 patients with malignant melanoma in the vagina after Ⅲ period;22 months stable disease in 1 cases of cervical malignant melanoma patients.Conclusion:the prognosis of malignant melanoma is poor.Extended surgical procedures did not improve survival and quality of life.At present,the main treatment is surgery combined with radiotherapy/chemotherapy,biological therapy and targeted therapy.

引文

[1]Chang SC,Chen CJ,Tseng HH,et al..Primary malignant melanoma of the vagina and cervix uteri;case report and literature review[J].ChinMed J,1992,50(4):341-342.
    [2]王亚军,常文庆,卜大伟.原发性生殖器恶性黑色素瘤15例临床分析[J].中华妇产科杂志,1997,32(2):226-228.
    [3]高浩成,龚美琴,高雪梅.女性生殖系统恶性黑色素瘤治疗现状[J].中国实用妇科与产科杂志,2015,31(2):177-181.
    [4]Van Geel AN,Den Bakker MA,Kirkels W,et al.Prognosis of pri?mary mucosal penile melanoma;a series of 19 Dutch patientsand 47 patients from the literature[J].Urology,2007,70(1):143-147.
    [5]Burmeister BH,Henderson MA,Ainslie J,et al.Adjuvant radiotherapy versus observation alone for patients at risk of lymphnodefield relapse after therapeutic lymphadenectomy for melanoma;a randomised trial[J].Lancet Oncol,2012,13(6):589-597.
    [6]张梅芳,向锦.女性原发性生殖道恶性黑色素瘤的临床病理特征及预后分析[J].中华肿瘤防治杂志,2010,(14):1119-1122.
    [7]Hodi FS,O Day SJ,McDermott DF,et al.Improved survival with ipilimumab in patients with metastatic melanoma[J].N Engl J Med,2010,363(8):711-723.
    [8]Tarhini AA,Cherian J,Moschos SJ,et al.Safety and efficacy of combination immunotherapy with interferon alfa-2b and treme-limumab in patients with stage IV melanoma[J].J Clin Oncol,2012,30(3);322-328.
    [9]Flaherty KT,Robert C,Hersey P,et al.Improved survival with MEK inhibition in BRAF-mutated melanoma[J].N Engl J Med,2012,367(2):107-114.
    [10]Heidorn SJ,Milagre C,Whittaker S,et al.Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF[J]Cell,2010,140(2):209-221