固体脂质结构对固体脂质防晒粒性能的影响
详细信息 查看官网全文
- 英文论文题名：The effect of solid lipid's structure on Nanostructured lipid carriers encapsulated with sun filter
- 论文作者：缪玉莲 ; 贾冰 ; 文静 ; 张婉萍
- 英文论文作者：MIAO Yu-Lian ; JIA Bing ; WEN Jing ; ZHANG Wan-Ping ; School of Perfume and Aroma Technology
- 年：2016
- 作者机构：上海应用技术学院香料香精技术与工程学院;
- 论文关键词：固体脂质结构 ; 脂肪酸 ; 脂肪醇 ; 酯
- 英文论文关键词：solid lipid's structure ; fatty alcohol ; fatty acid ; ester
- 会议召开时间：2016-06-15
- 会议录名称：第十一届中国化妆品学术研讨会论文集
- 英文会议录名称：The Proceedings of the 11th Seminar on Cosmetic China
- 语种：中文
- 分类号：TQ658.24
- 学会代码：ZGXE
- 会议名称：第十一届中国化妆品学术研讨会
- 会议地点：中国上海
- 主办单位：中国香料香精化妆品工业协会
- 学会名称：中国香料香精化妆品工业协会
- 页数：7
- 文件大小：673k
- 原文格式：O
- 会议级别：全国
摘要
主要研究固体脂质结构对固体脂质防晒粒性能的影响,实验通过研究脂肪酸、脂肪醇和酯类三种固体脂质微粒对固体脂质纳米颗粒(NLC)粒径、电位、pH、紫外防晒性能和光照稳定性的影响。实验结果表明:所有固体脂质防晒粒粒径在200nm左右,PDI均低于0.35,并且电位的绝对值均高于50mv;固体脂质为脂肪酸的体系pH呈中性,其他呈碱性;不同固体脂质形成固体脂质防晒粒中,脂肪醇形成的NLC由于粒径较小,其防晒性能越好;固体脂质防晒粒的光照稳定性优于普通乳液,且固体脂质为脂肪酸的光稳定性优于脂肪醇和酯类;综上该三种固体脂质均能够制备出固体脂质防晒粒,且拥有很好的特性和稳定性。
In this study,fatty alcohol,fatty acid and ester were used to investigate solid lipid's structure impact on nanostructured lipid carriers encapsulated with sun filter.The following physicochemical properties have been evaluated:particle size,zeta potential(ZP),pH and UV Performance.As a result,the particle size of NLCs was about 200 nm with PDI below 0.35 and zeta potential above 50 mv.When the solid lipid was fatty acids,the system present the neutral.While the others present the alkaline.Fatty alcohol has the strongest UV protection properties because of the smallest particle size.In vitro photo-stability,the fatty acids seemed to be the strongest solid lipid at enhancing the NLCs photo-stability.All the NLCs display a significant ability against conventional emulsion.All results indicated the three solid lipids can form NLCs and present diversity effects on characterization and stability.
In this study,fatty alcohol,fatty acid and ester were used to investigate solid lipid's structure impact on nanostructured lipid carriers encapsulated with sun filter.The following physicochemical properties have been evaluated:particle size,zeta potential(ZP),pH and UV Performance.As a result,the particle size of NLCs was about 200 nm with PDI below 0.35 and zeta potential above 50 mv.When the solid lipid was fatty acids,the system present the neutral.While the others present the alkaline.Fatty alcohol has the strongest UV protection properties because of the smallest particle size.In vitro photo-stability,the fatty acids seemed to be the strongest solid lipid at enhancing the NLCs photo-stability.All the NLCs display a significant ability against conventional emulsion.All results indicated the three solid lipids can form NLCs and present diversity effects on characterization and stability.
引文
[1]张小飞,邢传峰,果秋婷.川陈皮素固体脂质纳米粒的制备[J].中成药,2014,36(9):1857~1862.
[2]侯冬枝,谢长生,朱长虹固体脂质纳米粒的制备和载体结构的研究进展及其应用[J].中国医院药学杂志2004,24(1):43~45
[3]Torchilin V P.Liposomes as targetable drug carriers[J].Crit Rev Ther Drug Carrier Syst,1985,2(2):65.
[4]牛庆华,曹磊昌,张婉萍.固体脂质纳米微粒的制备及性能研究[J].日用化学工业,2009,39(5):77~79.
[5]Scalia S,Tursilli R,Sala N et al.Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-cyclodextrin.International Journal of Pharmaceutics,2006,320,79-85.
[6]Hu F Q,Jiang S P,Du Y Z et al.Preparation and characteristics of monostearin nanostructured lipid carriers[J].International Journal of Pharmaceutics,2006,314(1):83-89.
[7]Freitas C,Muller R H.Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle(SLN TM)dispersions[J].International Journal of Pharmaceutics,1998,168(2):221-229.
[8]Shi N L,Rui Z S.Guo D et al.Quercetin Loaded Nanostructured Lipid Carrier for food fortification:Preparation,Characterization and In Vitro study.Journal of Food Process Engineering,2015,38:93-106.
[9]Saupe A,Wissing S A,Lenk A et al.Solid Lipid Nanoparticles(SLN)and Nanostructured Lipid Carriers(NLC)-Structural investigations on two different carrier systems.Bio-Medical Materials and Engineering,2005,15,393-402.
[10]Heurtault B,Saulnier P,Pech B et al.Physico-chemical stability of colloidal lipid particles.Biomaterials,2003,24,4283-4300.
[11]Veerawat T,Rainer H M,Varaporn B J,Encapsulation of ascorbyl palmitate in nanostructured lipid carriers(NLC)—Effects of formulation parameters on physicochemical stability.International Journal of Pharmaceutics,2007,340,198-206.
[12]Liu M D,Yang Y Y,Xu H,Characterization and release of triptolide-loaded poly(D:L-lactic acid)nanoparticles.Eur.Polym.,2005,41,375-382.
[13]Lason E,Sikora E,Ogonowski J,Influence of process parameters on properties of nanostructured lipid carriers(NLC)formulation.Acta Biochim,2013,60,773-777.
[14]Carmelo Puglia,Elisabetta Damiani,Alessia Offerta et al.2014.Evaluation of nanostructured lipid carriers(NLC)and nanoemulsions as carriers for UV-filters:Characterization,in vitro penetration and photostability studies.European Journal of Pharmaceutical Sciences.51:211-217.
[15]A.Saupe,S.A.Wissing,A.Lenk et al.Solid Lipid Nanoparticles(SLN)and Nanostructured Lipid Carriers(NLC)-Structural investigations on two different carrier systems.Bio-Medical Materials and Engineering,15(2005),393-402.
[16]Y Goo,W P.Jin,I.S.Yoon,Solid lipid nanoparticles(SLNs)and nanostructured lipid carriers(NLCs):recent advances in drug delivery.Journal of Pharmaceutical Investigation,43(2013):353-362.
[2]侯冬枝,谢长生,朱长虹固体脂质纳米粒的制备和载体结构的研究进展及其应用[J].中国医院药学杂志2004,24(1):43~45
[3]Torchilin V P.Liposomes as targetable drug carriers[J].Crit Rev Ther Drug Carrier Syst,1985,2(2):65.
[4]牛庆华,曹磊昌,张婉萍.固体脂质纳米微粒的制备及性能研究[J].日用化学工业,2009,39(5):77~79.
[5]Scalia S,Tursilli R,Sala N et al.Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-cyclodextrin.International Journal of Pharmaceutics,2006,320,79-85.
[6]Hu F Q,Jiang S P,Du Y Z et al.Preparation and characteristics of monostearin nanostructured lipid carriers[J].International Journal of Pharmaceutics,2006,314(1):83-89.
[7]Freitas C,Muller R H.Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle(SLN TM)dispersions[J].International Journal of Pharmaceutics,1998,168(2):221-229.
[8]Shi N L,Rui Z S.Guo D et al.Quercetin Loaded Nanostructured Lipid Carrier for food fortification:Preparation,Characterization and In Vitro study.Journal of Food Process Engineering,2015,38:93-106.
[9]Saupe A,Wissing S A,Lenk A et al.Solid Lipid Nanoparticles(SLN)and Nanostructured Lipid Carriers(NLC)-Structural investigations on two different carrier systems.Bio-Medical Materials and Engineering,2005,15,393-402.
[10]Heurtault B,Saulnier P,Pech B et al.Physico-chemical stability of colloidal lipid particles.Biomaterials,2003,24,4283-4300.
[11]Veerawat T,Rainer H M,Varaporn B J,Encapsulation of ascorbyl palmitate in nanostructured lipid carriers(NLC)—Effects of formulation parameters on physicochemical stability.International Journal of Pharmaceutics,2007,340,198-206.
[12]Liu M D,Yang Y Y,Xu H,Characterization and release of triptolide-loaded poly(D:L-lactic acid)nanoparticles.Eur.Polym.,2005,41,375-382.
[13]Lason E,Sikora E,Ogonowski J,Influence of process parameters on properties of nanostructured lipid carriers(NLC)formulation.Acta Biochim,2013,60,773-777.
[14]Carmelo Puglia,Elisabetta Damiani,Alessia Offerta et al.2014.Evaluation of nanostructured lipid carriers(NLC)and nanoemulsions as carriers for UV-filters:Characterization,in vitro penetration and photostability studies.European Journal of Pharmaceutical Sciences.51:211-217.
[15]A.Saupe,S.A.Wissing,A.Lenk et al.Solid Lipid Nanoparticles(SLN)and Nanostructured Lipid Carriers(NLC)-Structural investigations on two different carrier systems.Bio-Medical Materials and Engineering,15(2005),393-402.
[16]Y Goo,W P.Jin,I.S.Yoon,Solid lipid nanoparticles(SLNs)and nanostructured lipid carriers(NLCs):recent advances in drug delivery.Journal of Pharmaceutical Investigation,43(2013):353-362.