Multisensory integration in macaque sensory and sensory-motor association cortex

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• 英文论文题名：Multisensory integration in macaque sensory and sensory-motor association cortex
• 论文作者：顾勇
• 英文论文作者：Yong Gu ; Institute of Neuroscience ; Chinese Academy of Sciences
• 年：2016
• 作者机构：Institute of Neuroscience, Chinese Academy of Sciences;
• 英文论文关键词：multisensory integration ; self-motion perception ; monkey ; sensory-motor transformation
• 会议召开时间：2016-08-04
• 会议录名称：第三届全国神经动力学学术会议论文摘要集
• 语种：英文
• 分类号：Q42
• 学会代码：AGLU
• 会议名称：第三届全国神经动力学学术会议
• 会议地点：中国甘肃敦煌
• 主办单位：中国力学学会动力学与控制专业委员会神经动力学专业组
• 学会名称：中国力学学会
• 页数：1
• 文件大小：609k
• 原文格式：D
• 会议级别：全国

摘要

To form a unified percept, the brain needs to integrate information from different sensory modalities. Although several brain areas have been found to encode multisensory information, little is known about how it is decoded and accumulated in downstream decision-making areas. We recorded from single neurons in lateral intraparietal area(LIP) in macaque monkeys performing a visual-vestibular multisensory decision-making task. We found that:(i) the rising phase of the vestibular ramping activity was substantially earlier than the visual one, indicating that LIP accumulates vestibular acceleration signals but visual velocity signals;(ii) LIP ramping activity in the visual, but not vestibular condition, significantly depended on the task-difficulty, a hallmark of gradual evidence accumulation in decision-making;(iii) task parameters(choice and modality) were randomly mixed at the single neuron level but largely separated at the population level in LIP; and(iv) when presented simultaneously, the two distinct sources of evidence(visual and vestibular) were integrated,resulting in an enhanced divergence of LIP population trajectories. However, the improvement is far from that predicted from optimal cue integration theory, as observed in the behavior. Our results may place important constraints on theoretical considerations for neural basis of multisensory integration and multisensory decision-making.
To form a unified percept, the brain needs to integrate information from different sensory modalities. Although several brain areas have been found to encode multisensory information, little is known about how it is decoded and accumulated in downstream decision-making areas. We recorded from single neurons in lateral intraparietal area(LIP) in macaque monkeys performing a visual-vestibular multisensory decision-making task. We found that:(i) the rising phase of the vestibular ramping activity was substantially earlier than the visual one, indicating that LIP accumulates vestibular acceleration signals but visual velocity signals;(ii) LIP ramping activity in the visual, but not vestibular condition, significantly depended on the task-difficulty, a hallmark of gradual evidence accumulation in decision-making;(iii) task parameters(choice and modality) were randomly mixed at the single neuron level but largely separated at the population level in LIP; and(iv) when presented simultaneously, the two distinct sources of evidence(visual and vestibular) were integrated,resulting in an enhanced divergence of LIP population trajectories. However, the improvement is far from that predicted from optimal cue integration theory, as observed in the behavior. Our results may place important constraints on theoretical considerations for neural basis of multisensory integration and multisensory decision-making.

引文

[1]Gu Y,Angelaki DE,De Angelis GC(2008)Neural correlates of multi-sensory cue integration in macaque area MSTd.Nature Neuroscience,11(10):1201-10.