离子液体在提取天然产物活性物质中的应用
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摘要
从离子液体的特性:密度、熔点、粘度和酸性;离子液体的分类:按阳离子的结构可以分为四大类、按阴离子的结构分为两大类;离子液体的提取方法:液-液萃取、超高压辅助提取、双水相萃取、微波辅助萃取和超声强化萃取,以及在提取天然产物中活性物质:黄酮类化合物、生物碱、蒽醌类、木脂素、挥发油、皂苷类等的应用这四方面入手来阐述离子液体在提取天然产物中活性物质中的应用。
The characteristics of ionic liquids:density,melting point,viscosity and acidity;ionic liquids classification:according to the cations they are divided into four categories,according to anions they are divided into two categories.Application of ionic liquids in extraction,ultra-high pressure assisted extraction,aqueous two-phase extraction,microwave-assisted extraction and ultrasonic enhanced extraction,as well as in the extraction of active substance from natural products:flavonoids,alkaloids,anthraquinones,wood Vitamins,volatile oils,saponins and other applications of these four aspects to disscuss the application of ionoc liquids in the active substance extractions from natural products.
The characteristics of ionic liquids:density,melting point,viscosity and acidity;ionic liquids classification:according to the cations they are divided into four categories,according to anions they are divided into two categories.Application of ionic liquids in extraction,ultra-high pressure assisted extraction,aqueous two-phase extraction,microwave-assisted extraction and ultrasonic enhanced extraction,as well as in the extraction of active substance from natural products:flavonoids,alkaloids,anthraquinones,wood Vitamins,volatile oils,saponins and other applications of these four aspects to disscuss the application of ionoc liquids in the active substance extractions from natural products.
引文
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[4] 田玉奎,邓晋,潘寿.离子液体中Lewis酸催化葡萄糖和果糖脱水制备5-羟甲基呋喃甲醛[J].催化学报,2011,32(6):997-1002.
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[6] 闫华,张红梅,张丽静,等.离子液体研究进展[J].山东化工,2016,45(23):55-57.
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[8] 田鹏.离子液体的物理化学性质[J].沈阳师范大学学报:自然科学版,2011,29(2):129-137.
[9] 徐钦良,李长安,陈梅兰,等.离子液体液-液萃取高效液相色谱测定水中邻苯二甲酸酯类物质[J].分析试验室,2010,29(6):93-96.
[10] 范云场,胡正良,陈梅兰,等.离子液体液-液萃取-高效液相色谱测定水中酚类化合物[J].分析化学,2008,36(9):1157-1161.
[11] 李敏,王秀玲,王力川,等.微波辅助离子液体提取酸枣仁中黄酮的研究[J].安徽农业科学,2015,43(27):225-227.
[12] 苏文斌,兰瑞家,徐瑶瑶.离子液体双水相微波辅助萃取姜黄中姜黄素[J].理化检验-化学分册,2014,50(5):579-582.
[13] 王迪,耿岩玲,王晓,等.超高压辅助离子液体提取/HPLC分析牛蒡子中牛蒡苷与牛蒡苷元[J].分析测试学报,2013,32(2):218-222.
[14] 陈梅梅,袁磊,高梅,等.离子液体双水相提取菜籽粕蛋白及其相行为的研究[J].中国粮油学报,2013,28(6):56-61.
[15] 王伟涛,张海德,蒋志国,等.离子液体双水相提取木瓜蛋白酶及条件优化[J].现代食品科技,2014,30(9):210-216.
[16] Tang X,Zhu D,Huai W,et al.Simultaneous extraction and separation of flavonoids and alkaloids from Crotalaria sessiliflora L.by microwave-assisted cloud-point extraction[J].Separation and Purification Technology,2017(175):266-273.
[17] 贲永光,苏健裕,杨鼎隆.基于离子液体超声辅助提取菊花绿原酸的试验研究[J].中国食品学报,2014,14(10):164-170.
[18] 冯洪建,邱灵佳,苏玉,等.离子液体微波辅助提取柠檬皮中果胶工艺的研究[J].江西化工,2013,4(40):213-217.
[19] Wang W,Li Q,Liu Y,et al.Ionic liquid-aqueous solution ultrasonic-assisted extraction of three kinds of alkaloids from Phellodendron amurense Rupr and optimize conditions use response surface[J].Ultrasonics Sonochemistry,2014,24:13-18.
[20] 陈明明,赵思敏,王毅帆,等.离子液体辅助超声提取黄柏总生物碱[J].沈阳药科大学学报,2015,32(11):859-863.
[21] 李明英.离子液体在天然活性物质提取中的应用研究进展[J].药学进展,2015,39(6):437-445.
[22] Severa G,Edwards M,Cooney M J.Bio-oil extraction of Jatropha curcas with ionic liquid co-solvent:Fate of biomass protein[J].Bioresource Technology,2017(226):255-261.
[23] Yunchang F,Xiaojing L,Ping S,et al.Highly effective extraction of hydroxycinnamic acids by hydrogen-bonding-functionalized ionic liquids[J].Separation Purification Technology,2017,1(57):1-28.
[24] Qin Z,San-hu Z,Jue C,et al.Application of ionic liquid-based microwave-assisted extraction of flavonoids from Scutellaria baicalensis Georgi[J].Journal of Chromatography B,2015(1002):411-417.
[25] 魏金凤,张志娟,李冬冬,等.离子液体辅助萃取山高粱中4种黄酮类成分的研究[J].中国中药杂志,2015,40(7):1305-1310.
[26] 李敏,王秀玲,王力川,等.微波辅助离子液体提取酸枣仁中黄酮的研究[J].安徽农业科学,2015,43(27):225-227.
[27] 汪雁,金光明,钱立生,等.离子液体提取构树叶总黄酮的工艺[J].化工进展,2016,35(2):328-331.
[28] 邓永利,周光明,陈军华,等.离子液体辅助超声萃取-高效液相色谱同时测定半边莲中6种黄酮类化合物[J].食品科学,2016,37(20):37-41.
[29] 王志兵,赵洋,辛楠,等.硅胶固载离子液体基质固相分散法提取蜂房中的酚酸和黄酮类化合物[J].现代食品科技,2015,31(3):158-164.
[30] 冯纪南,冯斯宇,邓斌.离子液体微波辅助提取臭牡丹中黄酮类化合物的研究[J].商丘师范学院学报,2015,31(3):51-55.
[31] L Linqiu,H Mingyuan,S Junli,et al.Rapid determination of alkaloids in Macleaya cordata using ionic liquid extraction followed by multiple reaction monitoring UPLC-MS/MS analysis[J].Journal of Pharmaceutical and Biomedical Analysis,2014(191):79-84.
[32] 刘婷婷,郁颖佳,段更利,等.离子液体-微波辅助提取钩藤中生物碱的工艺研究[J].中国新药与临床杂志,2013,32(6):482-486.
[33] 方海红,朱益雷,魏惠珍,等.离子液体作流动相添加剂高效液相色谱法分离茛菪类生物碱[J].分析测试学报,2016,35(5):614-617.
[34] 曹玺珉,吴昊,张晋,等.黄连黄柏提取液中3种生物碱的原位生成离子液体微萃取及HPLC测定[J].应用化学,2013,30(12):1489-1493.
[35] 赵盼盼,佟继铭,田沂凡,等.蒽醌类化合物药理作用研究进展[J].承德医学院学报,2016,33(2):152-155.
[36] 田杰,陈璇,白小红.中药材成分有机溶剂与离子液体分散液相微萃取方法的比较及其机理探讨[J].分析化学研究报告,2010,38(11):1593-1598.
[37] 史丽娟,彭胜,郑阳,等.离子液体超声波辅助法提取杜仲皮总木脂素的工艺研究[J].应用化工,2015,44(12):2250-2259.
[38] 翟玉娟,孙硕,汪子明,等.离子液体为微波吸收介质提取肉桂中的挥发油[J].分析化学,2009,37:179.
[39] 李兰杰,李绪文,丁健.超声辅助结合离子液体双水相提取-高效液相色谱法测定三七中5种稀有人参皂苷的含量[J].高等学校化工学报,2015,5(3):454-459.
[2] 赵继阳,俞所银,赵颖.离子液体熔点随咪哇环取代基变化的基本规律[J].江苏教育学院学报,2008,25(3):16-18.
[3] 李明英.离子液体在天然活性物质提取中的应用研究进展[J].药学进展,2015,39(6):437-445.
[4] 田玉奎,邓晋,潘寿.离子液体中Lewis酸催化葡萄糖和果糖脱水制备5-羟甲基呋喃甲醛[J].催化学报,2011,32(6):997-1002.
[5] 姚曦,岳永德,汤锋.离子液体在天然产物分离分析中的应用[J].林产化学与工业,2013,33(3):143-148.
[6] 闫华,张红梅,张丽静,等.离子液体研究进展[J].山东化工,2016,45(23):55-57.
[7] 曾理.化学溶剂离子液体研究进展[J].广州化工,2016,44(1):56-58.
[8] 田鹏.离子液体的物理化学性质[J].沈阳师范大学学报:自然科学版,2011,29(2):129-137.
[9] 徐钦良,李长安,陈梅兰,等.离子液体液-液萃取高效液相色谱测定水中邻苯二甲酸酯类物质[J].分析试验室,2010,29(6):93-96.
[10] 范云场,胡正良,陈梅兰,等.离子液体液-液萃取-高效液相色谱测定水中酚类化合物[J].分析化学,2008,36(9):1157-1161.
[11] 李敏,王秀玲,王力川,等.微波辅助离子液体提取酸枣仁中黄酮的研究[J].安徽农业科学,2015,43(27):225-227.
[12] 苏文斌,兰瑞家,徐瑶瑶.离子液体双水相微波辅助萃取姜黄中姜黄素[J].理化检验-化学分册,2014,50(5):579-582.
[13] 王迪,耿岩玲,王晓,等.超高压辅助离子液体提取/HPLC分析牛蒡子中牛蒡苷与牛蒡苷元[J].分析测试学报,2013,32(2):218-222.
[14] 陈梅梅,袁磊,高梅,等.离子液体双水相提取菜籽粕蛋白及其相行为的研究[J].中国粮油学报,2013,28(6):56-61.
[15] 王伟涛,张海德,蒋志国,等.离子液体双水相提取木瓜蛋白酶及条件优化[J].现代食品科技,2014,30(9):210-216.
[16] Tang X,Zhu D,Huai W,et al.Simultaneous extraction and separation of flavonoids and alkaloids from Crotalaria sessiliflora L.by microwave-assisted cloud-point extraction[J].Separation and Purification Technology,2017(175):266-273.
[17] 贲永光,苏健裕,杨鼎隆.基于离子液体超声辅助提取菊花绿原酸的试验研究[J].中国食品学报,2014,14(10):164-170.
[18] 冯洪建,邱灵佳,苏玉,等.离子液体微波辅助提取柠檬皮中果胶工艺的研究[J].江西化工,2013,4(40):213-217.
[19] Wang W,Li Q,Liu Y,et al.Ionic liquid-aqueous solution ultrasonic-assisted extraction of three kinds of alkaloids from Phellodendron amurense Rupr and optimize conditions use response surface[J].Ultrasonics Sonochemistry,2014,24:13-18.
[20] 陈明明,赵思敏,王毅帆,等.离子液体辅助超声提取黄柏总生物碱[J].沈阳药科大学学报,2015,32(11):859-863.
[21] 李明英.离子液体在天然活性物质提取中的应用研究进展[J].药学进展,2015,39(6):437-445.
[22] Severa G,Edwards M,Cooney M J.Bio-oil extraction of Jatropha curcas with ionic liquid co-solvent:Fate of biomass protein[J].Bioresource Technology,2017(226):255-261.
[23] Yunchang F,Xiaojing L,Ping S,et al.Highly effective extraction of hydroxycinnamic acids by hydrogen-bonding-functionalized ionic liquids[J].Separation Purification Technology,2017,1(57):1-28.
[24] Qin Z,San-hu Z,Jue C,et al.Application of ionic liquid-based microwave-assisted extraction of flavonoids from Scutellaria baicalensis Georgi[J].Journal of Chromatography B,2015(1002):411-417.
[25] 魏金凤,张志娟,李冬冬,等.离子液体辅助萃取山高粱中4种黄酮类成分的研究[J].中国中药杂志,2015,40(7):1305-1310.
[26] 李敏,王秀玲,王力川,等.微波辅助离子液体提取酸枣仁中黄酮的研究[J].安徽农业科学,2015,43(27):225-227.
[27] 汪雁,金光明,钱立生,等.离子液体提取构树叶总黄酮的工艺[J].化工进展,2016,35(2):328-331.
[28] 邓永利,周光明,陈军华,等.离子液体辅助超声萃取-高效液相色谱同时测定半边莲中6种黄酮类化合物[J].食品科学,2016,37(20):37-41.
[29] 王志兵,赵洋,辛楠,等.硅胶固载离子液体基质固相分散法提取蜂房中的酚酸和黄酮类化合物[J].现代食品科技,2015,31(3):158-164.
[30] 冯纪南,冯斯宇,邓斌.离子液体微波辅助提取臭牡丹中黄酮类化合物的研究[J].商丘师范学院学报,2015,31(3):51-55.
[31] L Linqiu,H Mingyuan,S Junli,et al.Rapid determination of alkaloids in Macleaya cordata using ionic liquid extraction followed by multiple reaction monitoring UPLC-MS/MS analysis[J].Journal of Pharmaceutical and Biomedical Analysis,2014(191):79-84.
[32] 刘婷婷,郁颖佳,段更利,等.离子液体-微波辅助提取钩藤中生物碱的工艺研究[J].中国新药与临床杂志,2013,32(6):482-486.
[33] 方海红,朱益雷,魏惠珍,等.离子液体作流动相添加剂高效液相色谱法分离茛菪类生物碱[J].分析测试学报,2016,35(5):614-617.
[34] 曹玺珉,吴昊,张晋,等.黄连黄柏提取液中3种生物碱的原位生成离子液体微萃取及HPLC测定[J].应用化学,2013,30(12):1489-1493.
[35] 赵盼盼,佟继铭,田沂凡,等.蒽醌类化合物药理作用研究进展[J].承德医学院学报,2016,33(2):152-155.
[36] 田杰,陈璇,白小红.中药材成分有机溶剂与离子液体分散液相微萃取方法的比较及其机理探讨[J].分析化学研究报告,2010,38(11):1593-1598.
[37] 史丽娟,彭胜,郑阳,等.离子液体超声波辅助法提取杜仲皮总木脂素的工艺研究[J].应用化工,2015,44(12):2250-2259.
[38] 翟玉娟,孙硕,汪子明,等.离子液体为微波吸收介质提取肉桂中的挥发油[J].分析化学,2009,37:179.
[39] 李兰杰,李绪文,丁健.超声辅助结合离子液体双水相提取-高效液相色谱法测定三七中5种稀有人参皂苷的含量[J].高等学校化工学报,2015,5(3):454-459.
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