稻黄单胞菌碳代谢在致病性中的作用研究进展
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摘要
碳代谢是稻黄单胞菌体内最基本的代谢之一.碳源的获取对于病原菌在寄主水稻体内成功建立寄生关系和生长繁殖尤为重要.营养驱动是稻黄单胞菌与水稻互作的重要方面,并且与其他致病性决定因素,如Ⅲ型分泌系统(T3SS)等常相关联.为此,对稻黄单胞菌碳代谢的途径与功能、碳代谢途径中编码催化酶基因的生物学特性,以及碳代谢与hrp(hypersensitive response and pathogenicity)系统、群体感应(quorum sensing,QS)的关联性等方面进行了归纳,对利用碳代谢途径防控水稻细菌病害的可能性进行了展望.
Carbon metabolism was one of the most basic metabolisms in Xanthomonas oryzae.Carbohydrate nutrient acquisition was crucial for pathogen to establish a successful parasitism and to grow,reproduce in host rice.Nutrition drive was also a vital aspect of rice-Xanthomonas oryzae interaction,and often associated with other crucial pathogenicity determinants,such as type Ⅲ secretion system(T3SS).It was summed up the carbon metabolism pathways and functions of Xanthomonas oryzae,the biological properties of related-genes encoding catalytic enzyme in carbon metabolism pathways,the relevance of carbon metabolism with the hrp(hypersensitive response and pathogenicity) system and quorum sensing(QS).In addition,it was discussed the prospects that carbon metabolic pathway might be used as a way to control rice bacterial diseases.
Carbon metabolism was one of the most basic metabolisms in Xanthomonas oryzae.Carbohydrate nutrient acquisition was crucial for pathogen to establish a successful parasitism and to grow,reproduce in host rice.Nutrition drive was also a vital aspect of rice-Xanthomonas oryzae interaction,and often associated with other crucial pathogenicity determinants,such as type Ⅲ secretion system(T3SS).It was summed up the carbon metabolism pathways and functions of Xanthomonas oryzae,the biological properties of related-genes encoding catalytic enzyme in carbon metabolism pathways,the relevance of carbon metabolism with the hrp(hypersensitive response and pathogenicity) system and quorum sensing(QS).In addition,it was discussed the prospects that carbon metabolic pathway might be used as a way to control rice bacterial diseases.
引文
[1]李争,熊鹂,纪志远,等.白叶枯病菌和细菌性条斑病菌多样性的TALE效应蛋白调控水稻抗(感)病性机理与利用策略[J].中国农业科学,2013,46(14):2894-2901.
[2]郭威.水稻条斑病菌致病相关基因的鉴定与功能研究[D].南京:南京农业大学,2011.
[3]Guo Wei,Cai Lulu,Zou Huasong,et al.Ketoglutarate transport protein Kgt P is secreted through the typeⅢsecretion system and contributes to virulence in Xanthomonas oryzae pv.oryzae[J].Applied and Environmental Microbiology,2012,78:5672-5681.
[4]Wang Li,Makino S,Subedee A,et al.Novel candidate virulence factors in rice pathogen Xanthomonas oryzae pv.oryzicola as revealed by mutational analysis[J].Applied and Environmental Microbiology,2007,73(24):8023-8027.
[5]Zou Huasong,Yuan Liang,Guo Wei,et al.Construction of a Tn5-tagged mutant library of Xanthomonas oryzae pv.oryzicola as an invaluable resource for functional genomics[J].Current Microbiology,2011,62(3):908-916.
[6]Guo Wei,Cui Yiping,Li Yurong,et al.Identification of seven Xanthomonas oryzae pv.oryzicola genes potentially involved in pathogenesis in rice[J].Microbiology,2012,158:505-518.
[7]Zou Lifang,Wang Xingping,Xiang Yong,et al.Elucidation of the hrp clusters of Xanthomonas oryzae pv.oryzicola that control the hypersensitive response in nonhost tobacco and pathogenicity in susceptible host rice[J].Applied and Environmental Microbiology,2006,72:6212-6224.
[8]Li Yurong,Che Yizhou,Zou Huasong,et al.Hpa2 required by Hrp F to translocate Xanthomonas oryzae transcriptional activator-like effectors into rice for pathogenicity[J].Applied and Environmental Microbiology,2011,77:3809-3818.
[9]Li Yurong,Zou Huasong,Che Yizhou,et al.A novel regulatory role of Hrp D6 in regulating hrp-hrc-hpa genes in Xanthomonas oryzae pv.oryzicola[J].Molecular Plant-Microbe Interactions,2011,24:1086-1101.
[10]Tang Dongjie,He Yongqiang,Feng Jiaxun,et al.Xanthomonas campestris pv.campestris possesses a single gluconeogenic pathway that is required for virulence[J].Journal of Bacteriology,2005,187:6231-6237.
[11]Tamir-Ariel D,Navon N,Burdman S.Identification of genes in Xanthomonas campestris pv.vesicatoria induced during its interaction with tomato[J].Journal of Bacteriology,2007,189:6359-6371.
[12]赵帅,张子宇,冯家勋.水稻黄单胞菌三型分泌系统效应物的研究进展[J].微生物学通报,2011,38(12):1828-1842.
[13]Zhao Yancun,Qian Guoliang,Yin Fangqun,et al.Proteomic analysis of the regulatory function of DSF-dependent quorum sensing in Xanthomonas oryzae pv.oryzicola[J].Microbial Pathogenesis,2011,50:48-55.
[14]Kim S Y,Kim J G,Lee B M,et al.Mutational analysis of the gum gene cluster required for xanthan biosynthesis in Xanthomonas oryzae pv.oryzae[J].Biotechnology Letters,2009,31:265-270.
[15]Zou Huasong,Song Xue,Zou Lifang,et al.Ecp A,an extracellular protease,is a specific virulence factor required by Xanthomonas oryzae pv.oryzicola but not by X.oryzae pv.oryzae in rice[J].Microbiology,2012,158:2372-2383.
[16]Guo Wei,Zou Lifang,Li Yurong,et al.Fructose-bisphophate aldolase exhibits functional roles between carbon metabolism and the hrp system in rice pathogen Xanthomonas oryzae pv.oryzicola[J].PLo S ONE,2012,7(2):e31855.
[17]Mellgren E M,Kloek A P,Kunkel B N.Mqo,a tricarboxylic acid cycle enzyme,is required for virulence of Pseudomonas syringae pv.tomato strain DC3000 on Arabidopsis thaliana[J].Journal of Bacteriology,2009,191:3132-3141.
[18]Eisenreich W,Dandekar T,Heesemann J,et al.Carbon metabolism of intracellular bacterial pathogens and possible links to virulence[J].Nature Reviews Microbiology,2010,8(6):401-412.
[19]Watt T F,Vucur M,Baumgarth B,et al.Low molecular weight plant extract induces metabolic changes and the secretion of extracellular enzymes,but has a negative effect on the expression of the type-Ⅲsecretion system in Xanthomonas campestris pv.campestris[J].Journal of Biotechnology,2009,140:59-67.
[20]Kim S Y,Lee B M,Cho J Y.Relationship between glucose catabolism and xanthan production in Xanthomonas oryzae pv.oryzae[J].Biotechnology Letters,2010,32(4):527-531.
[21]Lee B M,Park Y J,Park D S,et al.The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331,the bacterial blight pathogen of rice[J].Nucleic Acids Research,2005,33:577-586.
[22]Ochiai H,Inoue Y,Takeya M,et al.Genome sequence of Xanthomonas oryzae pv.oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity[J].Japan Agricultural Research Quarterly,2005,39:275-287.
[23]Salzberg S L,Sommer D D,Schatz M C,et al.Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv.oryzae PXO99A[J].BMC Genomics,2008,9:204-221.
[24]Bogdanove A J,Koebnik R,Lu Hong,et al.Two new complete genome sequences offer insight into host and tissue specificity of plant pathogenic Xanthomonas spp.[J].Journal of Bacteriology,2011,193(19):5450-5464.
[25]Guo Wei,Chu Cong,Yang Xiaoxia,et al.Phosphohexose mutase of Xanthomonas oryzae pv.oryzicola is negatively regulated by Hrp G and Hrp X,and required for the full virulence in rice[J].European Journal of Plant Pathology,2014,140:353-364.
[26]Guo Wei,Zou Lifang,Cai Lulu,et al.Glucose-6-phosphate dehydrogenase is required for extracellular polysaccharide production,cell motility and the full virulence of Xanthomonas oryzae pv.oryzicola[J].Microbial Pathogenesis,2015,78:87-94.
[27]Tsuge S,Ochiai H,Inoue Y,et al.Involvement of phosphoglucose isomerase in pathogenicity of Xanthomonas oryzae pv.oryzae[J].Phytopathology,2004,94:478-483.
[28]Lu Guangtao,Yang Zhengjiu,Peng Fangyin,et al.The role of glucose kinase in carbohydrate utilization and extracellular polysaccharide production in Xanthomonas campestris pathovar campestris[J].Microbiology,2007,153:4284-4294.
[29]Lu Guangtao,Xie Jiari,Chen Lei,et al.Glyceraldehyde-3-phosphate dehydrogenase of Xanthomonas campestris pv.campestris is required for extracellular polysaccharide production and full virulence[J].Microbiology,2009,155:1602-1612.
[30]谭旖宁,马增凤,陆光涛,等.野油菜黄单胞菌6-磷酸葡萄糖脱氢酶基因的初步分析[J].广西农业生物科学,2007,6(3):190-195.
[31]Yun M H,Torres P S,Oirdi M E,et al.Xanthan induces plant susceptibility by suppressing callose deposition[J].Plant Physiology,2006,141:178-187.
[32]Dow J M,Crossman L,Findlay K,et al.Biofilm dispersal in Xanthomonas campestris is controlled by cell-cell signaling and is required for full virulence to plants[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100:10995-11000.
[33]Letisse F,Chevallereau P,Simon J L,et al.The influence of metabolic network structures and energy requirements on xanthan gum yields[J].Journal of Biotechnology,2002,99:307-317.
[34]Jang S G,Lee B M,Cho J Y.Effect of modified glucose catabolism on xanthan production in Xanthomonas oryzae pv.oryzae[J].Journal of Industrial Microbiology&Biotechnology,2012,39:649-654.
[35]Lu Guangtao,Tang Yongqin,Li Caiyue,et al.An adenosine kinase exists in Xanthomonas campestris pathovar campestris and is involved in extracellular polysaccharide production,cell motility,and virulence[J].Journal of Bacteriology,2009,191:3639-3648.
[36]Chao Naixia,Wei Ke,Chen Qi,et al.The rsm A-like gene rsm A(Xcc)of Xanthomonas campestris pv.campestris is involved in the control of various cellular processes,including pathogenesis[J].Molecular Plant-Microbe Interactions,2008,21:411-423.
[37]Jiang Bole,Liu Jiao,Chen Lifeng,et al.Dsb B is required for the pathogenesis process of Xanthomonas campestris pv.campestris[J].Molecular Plant-Microbe Interactions,2008,21:1036-1045.
[38]Mc Carthy Y,Ryan R P,O'Donovan K,et al.The role of Pil Z domain proteins in the virulence of Xanthomonas campestris pathovar campestris[J].Molecular Plant Pathology,2008,9:819-824.
[39]Chen Lei,Hu Baishi,Qian Guoliang,et al.Identification and molecular characterization of twin-arginine translocation system(Tat)in Xanthomonas oryzae pv.oryzae strain PXO99[J].Archives of Microbiology,2009,191(2):163-170.
[40]殷芳群,赵延存,刘春晖,等.水稻细菌性条斑病菌中受DSF调控的鞭毛基因flg D、flg E的功能分析[J].微生物学报,2011,51(7):891-897.
[41]Tamir-Ariel D,Rosenberg T,Burdman S.The Xanthomonas campestris pv.vesicatoria cit H gene is expressed early in the infection process of tomato and is positively regulated by the Tct DE two-component regulatory system[J].Molecular Plant Pathology,2011,12:57-71.
[42]Li Yurong,Xiao Youlun,Zou Lifang,et al.Identification of Hrp X regulon genes in Xanthomonas oryzae pv.oryzicola using a GFP visualization technique[J].Archives of Microbiology,2012,194(4):281-291.
[43]Tang Xiaoyan,Xiao Yanmei,Zhou Jianmin.Regulation of the typeⅢsecretion system in phytopathogenic bacteria[J].Molecular Plant-Microbe Interactions,2006,19(11):1159-1166.
[44]肖友伦,李玉蓉,刘之洋,等.水稻条斑病菌hrp基因诱导表达系统的建立[J].微生物学报,2007,47(3):396-401.
[45]Tsuge S,Furutani A,Fukunaka R,et al.Expression of Xanthomonas oryzae pv.oryzae hrp genes in XOM2,a novel synthetic medium[J].Journal of General Plant Pathology,2002,68:363-370.
[46]孙蕾,吴茂森,陈华民,等.水稻白叶枯病菌Δrpfxoo基因缺失突变体DSF信号产生和毒性表达[J].微生物学报,2010,50(6):717-723.
[47]Zhou Lian,Yu Yonghong,Chen Xiping,et al.The multiple DSF-family QS signals are synthesized from carbohydrate and branched-chain amino acids via the FAS elongation cycle[J].Scientific Reports,2015,DOI:10.1038/srep13294.
[48]He Yawen,Wu Ji'en,Cha J S,et al.Rice bacterial blight pathogen Xanthomonas oryzae pv.oryzae produces multiple DSF-family signals in regulation of virulence factor production[J].BMC Microbiology,2010,10(1):1-9.
[49]He Yawen,Xu Min,Lin Kui,et al.Genome scale analysis of diffusible signal factor regulon in Xanthomonas campestris pv.campestris:Identification of novel cell-cell communication dependent genes and functions[J].Molecular Microbiology,2006,59:610-622.
[50]He Yawen,Zhang Lianhui.Quorum sensing and virulence regulation in Xanthomonas campestris[J].FEMS Microbiology Reviews,2008,32(5):842-857.
[2]郭威.水稻条斑病菌致病相关基因的鉴定与功能研究[D].南京:南京农业大学,2011.
[3]Guo Wei,Cai Lulu,Zou Huasong,et al.Ketoglutarate transport protein Kgt P is secreted through the typeⅢsecretion system and contributes to virulence in Xanthomonas oryzae pv.oryzae[J].Applied and Environmental Microbiology,2012,78:5672-5681.
[4]Wang Li,Makino S,Subedee A,et al.Novel candidate virulence factors in rice pathogen Xanthomonas oryzae pv.oryzicola as revealed by mutational analysis[J].Applied and Environmental Microbiology,2007,73(24):8023-8027.
[5]Zou Huasong,Yuan Liang,Guo Wei,et al.Construction of a Tn5-tagged mutant library of Xanthomonas oryzae pv.oryzicola as an invaluable resource for functional genomics[J].Current Microbiology,2011,62(3):908-916.
[6]Guo Wei,Cui Yiping,Li Yurong,et al.Identification of seven Xanthomonas oryzae pv.oryzicola genes potentially involved in pathogenesis in rice[J].Microbiology,2012,158:505-518.
[7]Zou Lifang,Wang Xingping,Xiang Yong,et al.Elucidation of the hrp clusters of Xanthomonas oryzae pv.oryzicola that control the hypersensitive response in nonhost tobacco and pathogenicity in susceptible host rice[J].Applied and Environmental Microbiology,2006,72:6212-6224.
[8]Li Yurong,Che Yizhou,Zou Huasong,et al.Hpa2 required by Hrp F to translocate Xanthomonas oryzae transcriptional activator-like effectors into rice for pathogenicity[J].Applied and Environmental Microbiology,2011,77:3809-3818.
[9]Li Yurong,Zou Huasong,Che Yizhou,et al.A novel regulatory role of Hrp D6 in regulating hrp-hrc-hpa genes in Xanthomonas oryzae pv.oryzicola[J].Molecular Plant-Microbe Interactions,2011,24:1086-1101.
[10]Tang Dongjie,He Yongqiang,Feng Jiaxun,et al.Xanthomonas campestris pv.campestris possesses a single gluconeogenic pathway that is required for virulence[J].Journal of Bacteriology,2005,187:6231-6237.
[11]Tamir-Ariel D,Navon N,Burdman S.Identification of genes in Xanthomonas campestris pv.vesicatoria induced during its interaction with tomato[J].Journal of Bacteriology,2007,189:6359-6371.
[12]赵帅,张子宇,冯家勋.水稻黄单胞菌三型分泌系统效应物的研究进展[J].微生物学通报,2011,38(12):1828-1842.
[13]Zhao Yancun,Qian Guoliang,Yin Fangqun,et al.Proteomic analysis of the regulatory function of DSF-dependent quorum sensing in Xanthomonas oryzae pv.oryzicola[J].Microbial Pathogenesis,2011,50:48-55.
[14]Kim S Y,Kim J G,Lee B M,et al.Mutational analysis of the gum gene cluster required for xanthan biosynthesis in Xanthomonas oryzae pv.oryzae[J].Biotechnology Letters,2009,31:265-270.
[15]Zou Huasong,Song Xue,Zou Lifang,et al.Ecp A,an extracellular protease,is a specific virulence factor required by Xanthomonas oryzae pv.oryzicola but not by X.oryzae pv.oryzae in rice[J].Microbiology,2012,158:2372-2383.
[16]Guo Wei,Zou Lifang,Li Yurong,et al.Fructose-bisphophate aldolase exhibits functional roles between carbon metabolism and the hrp system in rice pathogen Xanthomonas oryzae pv.oryzicola[J].PLo S ONE,2012,7(2):e31855.
[17]Mellgren E M,Kloek A P,Kunkel B N.Mqo,a tricarboxylic acid cycle enzyme,is required for virulence of Pseudomonas syringae pv.tomato strain DC3000 on Arabidopsis thaliana[J].Journal of Bacteriology,2009,191:3132-3141.
[18]Eisenreich W,Dandekar T,Heesemann J,et al.Carbon metabolism of intracellular bacterial pathogens and possible links to virulence[J].Nature Reviews Microbiology,2010,8(6):401-412.
[19]Watt T F,Vucur M,Baumgarth B,et al.Low molecular weight plant extract induces metabolic changes and the secretion of extracellular enzymes,but has a negative effect on the expression of the type-Ⅲsecretion system in Xanthomonas campestris pv.campestris[J].Journal of Biotechnology,2009,140:59-67.
[20]Kim S Y,Lee B M,Cho J Y.Relationship between glucose catabolism and xanthan production in Xanthomonas oryzae pv.oryzae[J].Biotechnology Letters,2010,32(4):527-531.
[21]Lee B M,Park Y J,Park D S,et al.The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331,the bacterial blight pathogen of rice[J].Nucleic Acids Research,2005,33:577-586.
[22]Ochiai H,Inoue Y,Takeya M,et al.Genome sequence of Xanthomonas oryzae pv.oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity[J].Japan Agricultural Research Quarterly,2005,39:275-287.
[23]Salzberg S L,Sommer D D,Schatz M C,et al.Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv.oryzae PXO99A[J].BMC Genomics,2008,9:204-221.
[24]Bogdanove A J,Koebnik R,Lu Hong,et al.Two new complete genome sequences offer insight into host and tissue specificity of plant pathogenic Xanthomonas spp.[J].Journal of Bacteriology,2011,193(19):5450-5464.
[25]Guo Wei,Chu Cong,Yang Xiaoxia,et al.Phosphohexose mutase of Xanthomonas oryzae pv.oryzicola is negatively regulated by Hrp G and Hrp X,and required for the full virulence in rice[J].European Journal of Plant Pathology,2014,140:353-364.
[26]Guo Wei,Zou Lifang,Cai Lulu,et al.Glucose-6-phosphate dehydrogenase is required for extracellular polysaccharide production,cell motility and the full virulence of Xanthomonas oryzae pv.oryzicola[J].Microbial Pathogenesis,2015,78:87-94.
[27]Tsuge S,Ochiai H,Inoue Y,et al.Involvement of phosphoglucose isomerase in pathogenicity of Xanthomonas oryzae pv.oryzae[J].Phytopathology,2004,94:478-483.
[28]Lu Guangtao,Yang Zhengjiu,Peng Fangyin,et al.The role of glucose kinase in carbohydrate utilization and extracellular polysaccharide production in Xanthomonas campestris pathovar campestris[J].Microbiology,2007,153:4284-4294.
[29]Lu Guangtao,Xie Jiari,Chen Lei,et al.Glyceraldehyde-3-phosphate dehydrogenase of Xanthomonas campestris pv.campestris is required for extracellular polysaccharide production and full virulence[J].Microbiology,2009,155:1602-1612.
[30]谭旖宁,马增凤,陆光涛,等.野油菜黄单胞菌6-磷酸葡萄糖脱氢酶基因的初步分析[J].广西农业生物科学,2007,6(3):190-195.
[31]Yun M H,Torres P S,Oirdi M E,et al.Xanthan induces plant susceptibility by suppressing callose deposition[J].Plant Physiology,2006,141:178-187.
[32]Dow J M,Crossman L,Findlay K,et al.Biofilm dispersal in Xanthomonas campestris is controlled by cell-cell signaling and is required for full virulence to plants[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100:10995-11000.
[33]Letisse F,Chevallereau P,Simon J L,et al.The influence of metabolic network structures and energy requirements on xanthan gum yields[J].Journal of Biotechnology,2002,99:307-317.
[34]Jang S G,Lee B M,Cho J Y.Effect of modified glucose catabolism on xanthan production in Xanthomonas oryzae pv.oryzae[J].Journal of Industrial Microbiology&Biotechnology,2012,39:649-654.
[35]Lu Guangtao,Tang Yongqin,Li Caiyue,et al.An adenosine kinase exists in Xanthomonas campestris pathovar campestris and is involved in extracellular polysaccharide production,cell motility,and virulence[J].Journal of Bacteriology,2009,191:3639-3648.
[36]Chao Naixia,Wei Ke,Chen Qi,et al.The rsm A-like gene rsm A(Xcc)of Xanthomonas campestris pv.campestris is involved in the control of various cellular processes,including pathogenesis[J].Molecular Plant-Microbe Interactions,2008,21:411-423.
[37]Jiang Bole,Liu Jiao,Chen Lifeng,et al.Dsb B is required for the pathogenesis process of Xanthomonas campestris pv.campestris[J].Molecular Plant-Microbe Interactions,2008,21:1036-1045.
[38]Mc Carthy Y,Ryan R P,O'Donovan K,et al.The role of Pil Z domain proteins in the virulence of Xanthomonas campestris pathovar campestris[J].Molecular Plant Pathology,2008,9:819-824.
[39]Chen Lei,Hu Baishi,Qian Guoliang,et al.Identification and molecular characterization of twin-arginine translocation system(Tat)in Xanthomonas oryzae pv.oryzae strain PXO99[J].Archives of Microbiology,2009,191(2):163-170.
[40]殷芳群,赵延存,刘春晖,等.水稻细菌性条斑病菌中受DSF调控的鞭毛基因flg D、flg E的功能分析[J].微生物学报,2011,51(7):891-897.
[41]Tamir-Ariel D,Rosenberg T,Burdman S.The Xanthomonas campestris pv.vesicatoria cit H gene is expressed early in the infection process of tomato and is positively regulated by the Tct DE two-component regulatory system[J].Molecular Plant Pathology,2011,12:57-71.
[42]Li Yurong,Xiao Youlun,Zou Lifang,et al.Identification of Hrp X regulon genes in Xanthomonas oryzae pv.oryzicola using a GFP visualization technique[J].Archives of Microbiology,2012,194(4):281-291.
[43]Tang Xiaoyan,Xiao Yanmei,Zhou Jianmin.Regulation of the typeⅢsecretion system in phytopathogenic bacteria[J].Molecular Plant-Microbe Interactions,2006,19(11):1159-1166.
[44]肖友伦,李玉蓉,刘之洋,等.水稻条斑病菌hrp基因诱导表达系统的建立[J].微生物学报,2007,47(3):396-401.
[45]Tsuge S,Furutani A,Fukunaka R,et al.Expression of Xanthomonas oryzae pv.oryzae hrp genes in XOM2,a novel synthetic medium[J].Journal of General Plant Pathology,2002,68:363-370.
[46]孙蕾,吴茂森,陈华民,等.水稻白叶枯病菌Δrpfxoo基因缺失突变体DSF信号产生和毒性表达[J].微生物学报,2010,50(6):717-723.
[47]Zhou Lian,Yu Yonghong,Chen Xiping,et al.The multiple DSF-family QS signals are synthesized from carbohydrate and branched-chain amino acids via the FAS elongation cycle[J].Scientific Reports,2015,DOI:10.1038/srep13294.
[48]He Yawen,Wu Ji'en,Cha J S,et al.Rice bacterial blight pathogen Xanthomonas oryzae pv.oryzae produces multiple DSF-family signals in regulation of virulence factor production[J].BMC Microbiology,2010,10(1):1-9.
[49]He Yawen,Xu Min,Lin Kui,et al.Genome scale analysis of diffusible signal factor regulon in Xanthomonas campestris pv.campestris:Identification of novel cell-cell communication dependent genes and functions[J].Molecular Microbiology,2006,59:610-622.
[50]He Yawen,Zhang Lianhui.Quorum sensing and virulence regulation in Xanthomonas campestris[J].FEMS Microbiology Reviews,2008,32(5):842-857.