色谱质谱技术在食品安全分析检测中的应用
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摘要
食品安全是关系国计民生的重要议题。准确、深入、高效的食品安全分析检测技术是防控食品安全事件发生及处理相关贸易纠纷、立法追责的基础和保障。色谱质谱技术作为高效的分离和检测手段是目前食品安全分析领域最重要、最主流的技术手段。近年来,色谱质谱领域的新发展也推动了食品安全分析检测向更快速,更有效,更可靠,更安全的目标迈进,本综述就其中最重要并有望代表未来食品安全分析发展趋势的色谱质谱技术做了总结和点评。如用于食品样品预处理的固相微萃取技术;气相色谱及气相色谱质谱联用技术中的快速气相色谱方法及其与质谱联用方法,二维气相色谱方法及其与质谱联用方法;液相色谱及液相色谱质谱联用技术中的超高效液相色谱及其与质谱联用方法,毛细管液相色谱和纳流液相色谱及其与质谱联用方法,超临界色谱及其与质谱联用方法,二维液相色谱及其与质谱联用方法;质谱分析技术中的超高分辨率质谱方法,常压敞开式离子源质谱技术等。
Food quality and safety have become one of the most concerns in recent years. Demand for the development and the applications of more efficient and more powerful tools to analyze food components and food contaminants have significantly increased. Chromatography and mass spectrometry are such tools that play major roles in food safety analysis. This review described the application of technology advances of chromatography and mass spectrometry in analysis of known and unknown compounds in food matrix. The summarized development included solid phase microextraction, high speed gas chromatography and its combination with mass spectrometry, two-dimensional gas chromatography and its combination with mass spectrometry, ultra-high pressure liquid chromatography and its combination with mass spectrometry, capillary-liquid chromatography and nano-liquid chromatography and their combination with mass spectrometry, supercritical fluid chromatography and its combination with mass spectrometry, two-dimensional liquid chromatography and its combination with mass spectrometry, high-resolution mass spectrometry and ambient mass spectrometry.
Food quality and safety have become one of the most concerns in recent years. Demand for the development and the applications of more efficient and more powerful tools to analyze food components and food contaminants have significantly increased. Chromatography and mass spectrometry are such tools that play major roles in food safety analysis. This review described the application of technology advances of chromatography and mass spectrometry in analysis of known and unknown compounds in food matrix. The summarized development included solid phase microextraction, high speed gas chromatography and its combination with mass spectrometry, two-dimensional gas chromatography and its combination with mass spectrometry, ultra-high pressure liquid chromatography and its combination with mass spectrometry, capillary-liquid chromatography and nano-liquid chromatography and their combination with mass spectrometry, supercritical fluid chromatography and its combination with mass spectrometry, two-dimensional liquid chromatography and its combination with mass spectrometry, high-resolution mass spectrometry and ambient mass spectrometry.
引文
[1]Anastassiades M,Lehotay SJ,?tajnbaher D,et al.Fast and easy multiresidue method employing acetonitrile extraction/partitioning and“dispersive solid-phase extraction”for the determination of pesticide residues in produce[J].J AOAC Int,2003,86(2):412?431.
[2]Mclean M,Malik A.2.16-Sol–Gel Materials in analytical microextraction A2-awliszyn,Janusz[M].Oxford:Acad Press,2012.
[3]Augusto F,Carasek E,Silva RGC,et al.New sorbents for extraction and microextraction techniques[J].J Chromatogr A,2010,1217(16):2533?2542.
[4]Kabir A,Furton KG,Malik A.Innovations in sol-gel microextraction phases for solvent-free sample preparation in analytical chemistry[J].Trac-Trend Anal Chem,2013,45:197?218.
[5]Bagheri H,Piri-Moghadam H,Naderi M.Towards greater mechanical,thermal and chemical stability in solid-phase microextraction[J].Trac-Trend Anal Chem,2012,34:126?139.
[6]Ibrahim WAW,Farhani H,Sanagi MM,et al.Solid phase microextraction using new sol–gel hybrid polydimethylsiloxane-2-hydroxymethyl-18-crown-6-coated fiber for determination of organophosphorous pesticides[J].J Chromatogr A,2010,1217(30):4890?4897.
[7]Yu H,Ho TD,Anderson JL.Ionic liquid and polymeric ionic liquid coatings in solid-phase microextraction[J].Trac-Trend Anal Chem,2013,45:219?232.
[8]Zhang Y,Wang X,Lin C,et al.A novel SPME fiber chemically linked with 1-vinyl-3-hexadecylimidazolium hexafluorophosphate ionic liquid coupled with GC for the simultaneous determination of pyrethroids in vegetables[J].Chromatographia,2012,75(13?14):789?797.
[9]Beltran J,Lopez F,Hernandez F.Solid-phase microextraction in pesticide residue analysis[J].J Chromatogr A,2000,885(1):389?404.
[10]Djozan D,Ebrahimi B,Mahkam M,et al.Evaluation of a new method for chemical coating of aluminum wire with molecularly imprinted polymer layer.Application for the fabrication of triazines selective solid-phase microextraction fiber[J].Anal Chim Acta,2010,674(1):40?48.
[11]Djozan D,Ebrahimi B.Preparation of new solid phase micro extraction fiber on the basis of atrazine-molecular imprinted polymer:Application for GC and GC/MS screening of triazine herbicides in water,rice and onion[J].Anal Chim Acta,2008,616(2):152?159.
[12]Djozan D,Mahkam M,Ebrahimi B.Preparation and binding study of solid-phase microextraction fiber on the basis of ametryn-imprinted polymer:application to the selective extraction of persistent triazine herbicides in tap water,rice,maize and onion[J].J Chromatogr A,2009,1216(12):2211?2219.
[13]Hu X,Fan Y,Zhang Y,et al.Molecularly imprinted polymer coated solid-phase microextraction fiber prepared by surface reversible addition–fragmentation chain transfer polymerization for monitoring of Sudan dyes in chilli tomato sauce and chilli pepper samples[J].Anal Chim Acta,2012,731:40?48.
[14]Hu X,Cai Q,Fan Y,et al.Molecularly imprinted polymer coated solid-phase microextraction fibers for determination of Sudan I–IV dyes in hot chili powder and poultry feed samples[J].J Chromatogr A,2012,1219:39?46.
[15]Yang Y,Chen J,Shi YP.Determination of diethylstilbestrol in milk using carbon nanotube-reinforced hollow fiber solid-phase microextraction combined with high-performance liquid chromatography[J].Talanta,2012,97:222?228.
[16]Song XY,Shi YP,Chen J.Carbon nanotubes-reinforced hollow fibre solid-phase microextraction coupled with high performance liquid chromatography for the determination of carbamate pesticides in apples[J].Food Chem,2013,139(1):246?252.
[17]Souza-SilvaéA,Gionfriddo E,Pawliszyn J.A critical review of the state of the art of solid-phase microextraction of complex matrices II.Food analysis[J].Trac-Trend Anal Chem,2015,71:236?248.
[18]Saison D,De Schutter DP,Delvaux F,et al.Optimisation of a complete method for the analysis of volatiles involved in the flavour stability of beer by solid-phase microextraction in combination with gas chromatography and mass spectrometry[J].J Chromatogr A,2008,1190(1):342?349.
[19]Saison D,De Schutter DP,Delvaux F,et al.Determination of carbonyl compounds in beer by derivatisation and headspace solid-phase microextraction in combination with gas chromatography and mass spectrometry[J].J Chromatogr A,2009,1216(26):5061?5068.
[20]Carasek E,Cudjoe E,Pawliszyn J.Fast and sensitive method to determine chloroanisoles in cork using an internally cooled solid-phase microextraction fiber[J].J Chromatogr A,2007,1138(1):10?17.
[21]JeleńHH,Dziadas M,Majcher M.Different headspace solid phase microextraction–Gas chromatography/mass spectrometry approaches to haloanisoles analysis in wine[J].J Chromatogr A,2013,1313:185?193.
[22]Kataoka H,Lord HL,Pawliszyn J.Applications of solid-phase microextraction in food analysis[J].J Chromatogr A,2000,880(1):35?62.
[23]Bai Z,Pilote A,Sarker PK,et al.In vivo solid-phase microextraction with in vitro calibration:determination of off-flavor components in live fish[J].Anal Chem,2013,85(4):2328?2332.
[24]Gionfriddo E,Naccarato A,Sindona G,et al.A reliable solid phase microextraction-gas chromatography–triple quadrupole mass spectrometry method for the assay of selenomethionine and selenomethylselenocysteine in aqueous extracts:difference between selenized and not-enriched selenium potatoes[J].Anal Chim Acta,2012,747:58?66.
[25]Mirnaghi FS,Mousavi F,Rocha SM,et al.Automated determination of phenolic compounds in wine,berry,and grape samples using 96-blade solid phase microextraction system coupled with liquid chromatography–tandem mass spectrometry[J].J Chromatogr A,2013,1276:12?19.
[26]Stanimirova I,stün B,Cajka T,et al.Tracing the geographical origin of honeys based on volatile compounds profiles assessment using pattern recognition techniques[J].Food Chem,2010,118(1):171?176.
[27]Donato P,Quinto Tranchida P,Dugo P,et al.Rapid analysis of food products by means of high speed gas chromatography[J].J Sep Sci,2007,30(4):508?526.
[28]Blumberg LM,Klee MS.Method translation and retention time locking in partition GC[J].Anal Chem,1998,70(18):3828?3839.
[29]Mondello L,Casilli A,Tranchida PQ,et al.Evaluation of fast gas chromatography and gas chromatography–mass spectrometry in the analysis of lipids[J].J Chromatogr A,2004,1035(2):237?247.
[30]Mondello L,Tranchida PQ,Dugo P,et al.Rapid,micro-scale preparation and very fast gas chromatographic separation of cod liver oil fatty acid methyl esters[J].J Pharm Biom,2006,41(5):1566?1570.
[31]Mondello L,Casilli A,Tranchida PQ,et al.Fast enantiomeric analysis of a complex essential oil with an innovative multidimensional gas chromatographic system[J].J Chromatogr A,2006,1105(1):11?16.
[32]Tranchida PQ,Presti ML,Costa R,et al.High-throughput analysis of bergamot essential oil by fast solid-phase microextraction–capillary gas chromatography–flame ionization detection[J].J Chromatogr A,2006,1103(1):162?165.
[33]HercegováA,D?m?t?rováM,MatisováE,et al.Fast gas chromatography with solid phase extraction clean-up for ultratrace analysis of pesticide residues in baby food[J].J Chromatogr A,2005,1084(1):46?53.
[34]Kirchner M,MatisováE,Otrekal R,et al.Search on ruggedness of fast gas chromatography–mass spectrometry in pesticide residues analysis[J].J Chromatogr A,2005,1084(1):63?70.
[35]D?m?t?rováM,Kirchner M,MatisováE,et al.Possibilities and limitations of fast GC with narrow-bore columns[J].J Sep Sci,2006,29(8):1051?1063.
[36]HercegováA,D?m?t?rováM,Kru?licováD,et al.Comparison of sample preparation methods combined with fast gas chromatography–mass spectrometry for ultratrace analysis of pesticide residues in baby food[J].J Sep Sci,2006,29(8):1102?1109.
[37]Pursch M,Sun K,Winniford B,et al.Modulation techniques and applications in comprehensive two-dimensional gas chromatography(GC×GC)[J].Anal Bioanal Chem,2002,373(6):356?367.
[38]Ryan D,Watkins P,Smith J,et al.Analysis of methoxypyrazines in wine using headspace solid phase microextraction with isotope dilution and comprehensive two-dimensional gas chromatography[J].J Sep Sci,2005,28(9-10):1075?1082.
[39]Cardeal Z,De Souza P,Da Silva MG,et al.Comprehensive two-dimensional gas chromatography for fingerprint pattern recognition in cacha?a production[J].Talanta,2008,74(4):793?799.
[40]Friedrich JE,Acree TE.Gas chromatography olfactometry(GC/O)of dairy products[J].Int Dairy J,1998,8(3):235?241.
[41]Zhu S,Lu X,Ji K,et al.Characterization of flavor compounds in Chinese liquor Moutai by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry[J].Anal Chim Acta,2007,597(2):340?348.
[42]Bianchi F,Careri M,Conti C,et al.Comparison of comprehensive two‐dimensional gas chromatography‐time‐of flight mass spectrometry and gas chromatography-mass spectrometry for the qualitative characterisation of roasted barley by solid-phase microextraction[J].J Sep Sci,2007,30(4):527?533.
[43]Mondello L,Casilli A,Tranchida PQ,et al.Comprehensive multidimensional GC for the characterization of roasted coffee beans[J].J Sep Sci,2004,27(5?6):442?450.
[44]CˇAjka TD,Haj lovμJ,Cochran J,et al.Original Paper Solid phase microextraction–comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry for the analysis of honey volatiles[J].J Sep Sci,2007,30:534?546.
[45]Vaz-Freire LT,Da Silva MG,Freitas AC.Comprehensive two-dimensional gas chromatography for fingerprint pattern recognition in olive oils produced by two different techniques in Portuguese olive varieties Galega Vulgar,Cobran?osa e Carrasquenha[J].Anal Chim Acta,2009,633(2):263?270.
[46]Williams A,Ryan D,Guasca AO,et al.Analysis of strawberry volatiles using comprehensive two-dimensional gas chromatography with headspace solid-phase microextraction[J].J Chromatogr B,2005,817(1):97?107.
[47]O’mahony J,Clarke L,Whelan M,et al.The use of ultra-high pressure liquid chromatography with tandem mass spectrometric detection in the analysis of agrochemical residues and mycotoxins in food challenges and applications[J].J Chromatogr A,2013,1292:83?95.
[48]Whelan M,Kinsella B,Furey A,et al.Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography–tandem mass spectrometry with rapid polarity switching[J].J Chromatogr A,2010,1217(27):4612?4622.
[49]Leandro CC,Hancock P,Fussell RJ,et al.Comparison of ultra-performance liquid chromatography and high-performance liquid chromatography for the determination of priority pesticides in baby foods by tandem quadrupole mass spectrometry[J].J Chromatogr A,2006,1103(1):94?101.
[50]Duffy E,Rambaud L,Le Bizec B,et al.Determination of hormonal growth promoters in bovine hair:comparison of liquid chromatography–mass spectrometry and gas chromatography–mass spectrometry methods for estradiol benzoate and nortestosterone decanoate[J].Anal Chim Acta,2009,637(1):165?172.
[51]Van Poucke C,Van Vossel E,Van Peteghem C.Fractionation of free and conjugated steroids for the detection of boldenone metabolites in calf urine with ultra‐performance liquid chromatography/tandem mass spectrometry[J].Rapid Commun Mass Sp,2008,22(15):2324?2332.
[52]He XW,Ying Z,Jiang QW.Simultaneous analysis of nine estrogens in milk powder with ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry[J].Chin J Anal Chem,2011,39(9):1323?1328.
[53]Yang F,Liu Z,Lin Y,et al.Development an UHPLC-MS/MS method for detection ofβ-agonist residues in milk[J].Food Anal Method,2012,5(1):138?147.
[54]Shao B,Jia X,Zhang J,et al.Multi-residual analysis of 16β-agonists in pig liver,kidney and muscle by ultra performance liquid chromatography tandem mass spectrometry[J].Food Chem,2009,114(3):1115?1121.
[55]Zhang J,Shao B,Yin J,et al.Simultaneous detection of residues ofβ-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry[J].J Chromatogr B,2009,877(20):1915?1922.
[56]Nielen M,Lasaroms J,Essers M,et al.Multiresidue analysis of beta-agonists in bovine and porcine urine,feed and hair using liquid chromatography electrospray ionisation tandem mass spectrometry[J].Anal Bioanal Chem,2008,391(1):199?210.
[57]Zhang H,Ren Y,Bao X.Simultaneous determination of(fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography–tandem mass spectrometry[J].J Pharm Biom,2009,49(2):367?374.
[58]Lombardo-AgüíM,García-Campa?a AM,Gámiz-Gracia L,et al.Determination of quinolones of veterinary use in bee products by ultra-high performance liquid chromatography–tandem mass spectrometry using a Qu ECh ERS extraction procedure[J].Talanta,2012,93:193?199.
[59]Zhao XT,Lin QB,Song H,et al.Development of an immunoaffinity chromatography purification and ultra performance liquid chromatography tandem mass spectrometry method for determination of 12 sulfonamides in beef and milk[J].J Agric Food Chem,2011,59(18):9800?9805.
[60]She YX,Liu J,Wang J,et al.Determination of sulfonamides in bovine milk by ultra performance liquid chromatography combined with quadrupole mass spectrometry[J].Anal Lett,2010,43(14):2246?2256.
[61]Mcdonald M,Mannion C,Rafter P.A confirmatory method for the simultaneous extraction,separation,identification and quantification of Tetracycline,Sulphonamide,Trimethoprim and Dapsone residues in muscle by ultra-high-performance liquid chromatography–tandem mass spectrometry according to Commission Decision 2002/657/EC[J].J Chromatogr A,2009,1216(46):8110?8116.
[62]Zhang X,Xu H,Zhang H,et al.Simultaneous determination of albendazole and its metabolites in fish muscle tissue by stable isotope dilution ultra-performance liquid chromatography tandem mass spectrometry[J].Anal Bioanal Chem,2011,401(2):727?734.
[63]Xia X,Dong Y,Luo P,et al.Determination of benzimidazole residues in bovine milk by ultra-high performance liquid chromatography–tandem mass spectrometry[J].J Chromatogr B,2010,878(30):3174?3180.
[64]Hu T,Peng T,Li X-J,et al.Simultaneous determination of thirty non-steroidal anti-inflammatory drug residues in swine muscle by ultra-high-performance liquid chromatography with tandem mass spectrometry[J].J Chromatogr A,2012,1219:104?113.
[65]Mol HG,Plaza-Bola?os P,Zomer P,et al.Toward a generic extraction method for simultaneous determination of pesticides,mycotoxins,plant toxins,and veterinary drugs in feed and food matrixes[J].Anal Chem,2008,80(24):9450?9459.
[66]Herrmann A,Rosén J,Jansson D,et al.Evaluation of a generic multi-analyte method for detection of>100 representative compounds correlated to emergency events in 19 food types by ultrahigh-pressure liquid chromatography–tandem mass spectrometry[J].J Chromatogr A,2012,1235:115?124.
[67]Zhan J,Yu XJ,Zhong YY,et al.Generic and rapid determination of veterinary drug residues and other contaminants in raw milk by ultra performance liquid chromatography–tandem mass spectrometry[J].J Chromatogr B,2012,906:48?57.
[68]Fanali C,Dugo L,Dugo P,et al.Capillary-liquid chromatography(CLC)and nano-LC in food analysis[J].Trac-Trend Anal Chem,2013,52:226?238.
[69]Fanali C,Dugo L,D'orazio G,et al.Analysis of anthocyanins in commercial fruit juices by using nano-liquid chromatography‐electrospray‐mass spectrometry and high‐performance liquid chromatography with UV-vis detector[J].J Sep Sci,2011,34(2):150?159.
[70]Hu F,Deng C,Liu Y,et al.Quantitative determination of chlorogenic acid in Honeysuckle using microwave-assisted extraction followed by nano-LC-ESI mass spectrometry[J].Talanta,2009,77(4):1299?1303.
[71]Hughey CA,Wilcox B,Minardi CS,et al.Capillary liquid chromatography–mass spectrometry for the rapid identification and quantification of almond flavonoids[J].J Chromatogr A,2008,1192(2):259?265.
[72]Xie W,Mirocha CJ,Chen J.Detection of two naturally occurring structural isomers of partially hydrolyzed fumonisin B1 in corn by on-line capillary liquid chromatography-fast atom bombardment mass spectrometry[J].J Agric Food Chem,1997,45(4):1251?1255.
[73]Aqai P,Peters J,Gerssen A,et al.Immunomagnetic microbeads for screening with flow cytometry and identification with nano-liquid chromatography mass spectrometry of ochratoxins in wheat and cereal[J].Anal Bioanal Chem,2011,400(9):3085?3096.
[74]Kruve A,Haapala M,Saarela V,et al.Feasibility of capillary liquid chromatography–microchip-atmospheric pressure photoionization–mass spectrometry for pesticide analysis in tomato[J].Anal Chim Acta,2011,696(1):77?83.
[75]Onisko BC,Tambling DR,Gorder GW,et al.Identification of fonofos metabolites in Latuca sativa,Beta vulgaris,and Triticum aestivum by packed capillary flow fast atom bombardment tandem mass spectrometry[J].J Agric Food Chem,2002,50(7):1922?1928.
[76]Halvorsen B,Thomsen C,Greibrokk T,et al.Determination of fenpyroximate in apples by supercritical fluid extraction and packed capillary liquid chromatography with UV detection[J].J Chromatogr A,2000,880(1):121?128.
[77]Rosales-Conrado N,León-González M,Pérez-Arribas L,et al.Capillary liquid chromatography of chlorophenoxy acid herbicides and their esters in apple juice samples after preconcentration on a cation exchanger based on polydivinylbenzene-N-vinylpyrrolidone[J].J Chromatogr A,2005,1076(1):202?206.
[78]Lucas-Delfa M,Pérez-Arribas L,Navarro-Villoslada F,et al.Determination of chlorophenoxy acid and dicamba herbicide residues by capillary reversed-phase liquid chromatography[J].J Liquid Chromatogr Relat Technol,2000,23(5):755?767.
[79]Yakovleva J,Davidsson R,Bengtsson M,et al.Microfluidic enzyme immunosensors with immobilised protein A and G using chemiluminescence detection[J].Biosens Bioelectron,2003,19(1):21?34.
[80]D’orazio G,Cifuentes A,Fanali S.Chiral nano-liquid chromatography–mass spectrometry applied to amino acids analysis for orange juice profiling[J].Food Chem,2008,108(3):1114?1121.
[81]Domínguez-Vega E,Crego AL,Lomsadze K,et al.Enantiomeric separation of FMOC-amino acids by nano-LC and CEC using a new chiral stationary phase,cellulose tris(3-chloro-4-methylphenylcarbamate)[J].Electrophoresis,2011,32(19):2700?2707.
[82]Guillén-Casla V,Rosales-Conrado N,León-González M,et al.Determination of serotonin and its precursors in chocolate samples by capillary liquid chromatography with mass spectrometry detection[J].J Chromatogr A,2012,1232:158?165.
[83]Rizzello CG,Coda R,De Angelis M,et al.Long-term fungal inhibitory activity of water-soluble extract from Amaranthus spp.seeds during storage of gluten-free and wheat flour breads[J].Int J Food Microbiol,2009,131(2):189?196.
[84]Coda R,Rizzello CG,Nigro F,et al.Long-term fungal inhibitory activity of water-soluble extracts of Phaseolus vulgaris cv.Pinto and sourdough lactic acid bacteria during bread storage[J].Appl Environ Microb(AEM),2008,74(23):7391?7398.
[85]Rizzello CG,De AM,Di CR,et al.Highly efficient gluten degradation by lactobacilli and fungal proteases during food processing:new perspectives for celiac disease[J].Appl Environ Microb(AEM),2007,73(14):4499?4507.
[86]De AM,Rizzello CG,Fasano A,et al.VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue probiotics and gluten intolerance[J].BBA-Mol Basis Dis,2006,1762(1):80?93.
[87]Gebriel M,Uleberg KE,Larssen E,et al.Cod(Gadus morhua)muscle proteome cataloging using 1D-PAGE protein separation,nano-liquid chromatography peptide fractionation,and linear trap quadrupole(LTQ)mass spectrometry[J].J Agric Food Chem,2010,58(23):12307?12312.
[88]Sawasdipuksa N,Sumner LW,Lei Z,et al.Proteome analysis of Pithecellobium dulce seeds using two-dimensional gel electrophoresis and tandem mass spectrometry[J].J Sci Food Agr,2009,89(8):1284?1291.
[89]Kwon SW.Profiling of soluble proteins in wine by nano-high-performance liquid chromatography/tandem mass spectrometry[J].J Agric Food Chem,2004,52(24):7258?7263.
[90]Bianco L,Lopez L,Scalone AG,et al.Strawberry proteome characterization and its regulation during fruit ripening and in different genotypes[J].J Prot,2009,72(4):586?607.
[91]Bernal JL,Martín MT,Toribio L.Supercritical fluid chromatography in food analysis[J].J Chromatogr A,2013,1313:24?36.
[92]Rocco A,Aturki Z,Fanali S.Chiral separations in food analysis[J].Trac-Trend Anal Chem,2013,52:206?225.
[93]Tranchida PQ,Donato P,Cacciola F,et al.Potential of comprehensive chromatography in food analysis[J].Trac-Trend Anal Chem,2013,52:186?205.
[94]Mondello L,Tranchida P,Stanek V,et al.Silver-ion reversed-phase comprehensive two-dimensional liquid chromatography combined with mass spectrometric detection in lipidic food analysis[J].J Chromatogr A,2005,1086(1):91?98.
[95]Dugo P,Kumm T,Crupi M,et al.Comprehensive two-dimensional liquid chromatography combined with mass spectrometric detection in the analyses of triacylglycerols in natural lipidic matrixes[J].J Chromatogr A,2006,1112(1):269?275.
[96]Dugo P,Kumm T,Lo Presti M,et al.Determination of triacylglycerols in donkey milk by using high performance liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry[J].J Sep Sci,2005,28(9?10):1023?1030.
[97]Dugo P,Kumm T,Chiofalo B,et al.Separation of triacylglycerols in a complex lipidic matrix by using comprehensive two-dimensional liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometric detection[J].J Sep Sci,2006,29(8):1146?1154.
[98]Van Der Klift EJ,Vivó-Truyols G,Claassen FW,et al.Comprehensive two-dimensional liquid chromatography with ultraviolet,evaporative light scattering and mass spectrometric detection of triacylglycerols in corn oil[J].J Chromatogr A,2008,1178(1):43?55.
[99]Mondello L,Beccaria M,Donato P,et al.Comprehensive two-dimensional liquid chromatography with evaporative light-scattering detection for the analysis of triacylglycerols in Borago officinalis[J].J Sep Sci,2011,34(6):688?692.
[100]Dugo P,Fawzy N,Cichello F,et al.Stop-flow comprehensive two-dimensional liquid chromatography combined with mass spectrometric detection for phospholipid analysis[J].J Chromatogr A,2013,1278:46?53.
[101]Li M,Yang L,Bai Y,et al.Analytical methods in lipidomics and their applications[J].Anal Chem,2013,86(1):161?175.
[102]Li M,Tong X,Lv P,et al.A not-stop-flow online normal-/reversed-phase two-dimensional liquid chromatography–quadrupole time-of-flight mass spectrometry method for comprehensive lipid profiling of human plasma from atherosclerosis patients[J].J Chromatogr A,2014,1372:110?119.
[103]Li M,Feng B,Liang Y,et al.Lipid profiling of human plasma from peritoneal dialysis patients using an improved 2D(NP/RP)LC-QTo F MS method[J].Anal Bioanal Chem,2013,405(21):6629?6638.
[104]Nie H,Liu R,Yang Y,et al.Lipid profiling of rat peritoneal surface layer by an online NP/RP 2D LC-QTo F-MS system[J].J Lipid Res,2010,51:2833?2844.
[105]De Koning S,Janssen HG,Van Deursen M,et al.Automated on-line comprehensive two-dimensional LC×GC and LC×GC-To F MS:Instrument design and application to edible oil and fat analysis[J].J Sep Sci,2004,27(5?6):397?409.
[106]De KS,Janssen HG,Udo AT.Characterization of triacylglycerides from edible oils and fats using single and multidimensional techniques[J].LC GC EUR,2006,19(11):590?600.
[107]Fran?ois I,Sandra P.Comprehensive supercritical fluid chromatography×reversed phase liquid chromatography for the analysis of the fatty acids in fish oil[J].J Chromatogr A,2009,1216(18):4005?4012.
[108]Fran?ois I,Pereira Ad S,Sandra P.Considerations on comprehensive and off-line supercritical fluid chromatography reversed-phase liquid chromatography for the analysis of triacylglycerols in fish oil[J].J Sep Sci,2010,33(10):1504?1512.
[109]Wang X,Wang S,Cai Z.The latest developments and applications of mass spectrometry in food-safety and quality analysis[J].Trac-Trend Anal Chem,2013,52:170?185.
[110]Senyuva HZ,G?kmen V,Sarikaya EA.Future perspectives in Orbitrap?-high-resolution mass spectrometry in food analysis:a review[J].Food Addit Contam A,2015,32(10):1568?1606.
[111]Gómez-Pérez ML,Plaza-Bola?os P,Romero-González R,et al.Comprehensive qualitative and quantitative determination of pesticides and veterinary drugs in honey using liquid chromatography–orbitrap high resolution mass spectrometry[J].J Chromatogr A,2012,1248:130?138.
[112]Monaci L,De Angelis E,Visconti A.Determination of deoxynivalenol,T-2 and HT-2 toxins in a bread model food by liquid chromatography–high resolution-Orbitrap-mass spectrometry equipped with a high-energy collision dissociation cell[J].J Chromatogr A,2011,1218(48):8646?8654.
[113]Mol HG,Zomer P,De Koning M.Qualitative aspects and validation of a screening method for pesticides in vegetables and fruits based on liquid chromatography coupled to full scan high resolution(Orbitrap)mass spectrometry[J].Anal Bioanal Chem,2012,403(10):2891?2908.
[114]Yeboah SO,Mitei YC,Ngila JC,et al.Compositional and structural studies of the major and minor components in three cameroonian seed oils by GC–MS,ESI-FTICR-MS and HPLC[J].J Am Oil Chem Soc,2011,88(10):1539?1549.
[115]Chang C,Xu G,Bai Y,et al.Online coupling of capillary electrophoresis with direct analysis in real time mass spectrometry[J].Anal Chem,2012,85(1):170?176.
[116]Shen Y,Van Beek TA,Claassen FW,et al.Rapid control of Chinese star anise fruits and teas for neurotoxic anisatin by direct analysis in real time high resolution mass spectrometry[J].J Chromatogr A,2012,1259:179?186.
[117]FarréM,PicóY,BarcelóD.Direct peel monitoring of xenobiotics in fruit by direct analysis in real time coupled to a linear quadrupole ion trap–orbitrap mass spectrometer[J].Anal Chem,2013,85(5):2638?2644.
[118]Nielen M,Hooijerink H,Zomer P,et al.Desorption electrospray ionization mass spectrometry in the analysis of chemical food contaminants in food[J].Trac-Trend Anal Chem,2011,30(2):165?180.
[119]García-Reyes JF,Jackson AU,Molina-DíAz A,et al.Desorption electrospray ionization mass spectrometry for trace analysis of agrochemicals in food[J].Anal Chem,2008,81(2):820?829.
[120]Galhena AS,Harris GA,Kwasnik M,et al.Enhanced direct ambient analysis by differential mobility-filtered desorption electrospray ionization-mass spectrometry[J].Anal Chem,2010,82(22):9159?9163.
[121]Li X,Hu B,Ding J,et al.Rapid characterization of complex viscous samples at molecular levels by neutral desorption extractive electrospray ionization mass spectrometry[J].Nat Protoc,2011,6(7):1010?1025.
[2]Mclean M,Malik A.2.16-Sol–Gel Materials in analytical microextraction A2-awliszyn,Janusz[M].Oxford:Acad Press,2012.
[3]Augusto F,Carasek E,Silva RGC,et al.New sorbents for extraction and microextraction techniques[J].J Chromatogr A,2010,1217(16):2533?2542.
[4]Kabir A,Furton KG,Malik A.Innovations in sol-gel microextraction phases for solvent-free sample preparation in analytical chemistry[J].Trac-Trend Anal Chem,2013,45:197?218.
[5]Bagheri H,Piri-Moghadam H,Naderi M.Towards greater mechanical,thermal and chemical stability in solid-phase microextraction[J].Trac-Trend Anal Chem,2012,34:126?139.
[6]Ibrahim WAW,Farhani H,Sanagi MM,et al.Solid phase microextraction using new sol–gel hybrid polydimethylsiloxane-2-hydroxymethyl-18-crown-6-coated fiber for determination of organophosphorous pesticides[J].J Chromatogr A,2010,1217(30):4890?4897.
[7]Yu H,Ho TD,Anderson JL.Ionic liquid and polymeric ionic liquid coatings in solid-phase microextraction[J].Trac-Trend Anal Chem,2013,45:219?232.
[8]Zhang Y,Wang X,Lin C,et al.A novel SPME fiber chemically linked with 1-vinyl-3-hexadecylimidazolium hexafluorophosphate ionic liquid coupled with GC for the simultaneous determination of pyrethroids in vegetables[J].Chromatographia,2012,75(13?14):789?797.
[9]Beltran J,Lopez F,Hernandez F.Solid-phase microextraction in pesticide residue analysis[J].J Chromatogr A,2000,885(1):389?404.
[10]Djozan D,Ebrahimi B,Mahkam M,et al.Evaluation of a new method for chemical coating of aluminum wire with molecularly imprinted polymer layer.Application for the fabrication of triazines selective solid-phase microextraction fiber[J].Anal Chim Acta,2010,674(1):40?48.
[11]Djozan D,Ebrahimi B.Preparation of new solid phase micro extraction fiber on the basis of atrazine-molecular imprinted polymer:Application for GC and GC/MS screening of triazine herbicides in water,rice and onion[J].Anal Chim Acta,2008,616(2):152?159.
[12]Djozan D,Mahkam M,Ebrahimi B.Preparation and binding study of solid-phase microextraction fiber on the basis of ametryn-imprinted polymer:application to the selective extraction of persistent triazine herbicides in tap water,rice,maize and onion[J].J Chromatogr A,2009,1216(12):2211?2219.
[13]Hu X,Fan Y,Zhang Y,et al.Molecularly imprinted polymer coated solid-phase microextraction fiber prepared by surface reversible addition–fragmentation chain transfer polymerization for monitoring of Sudan dyes in chilli tomato sauce and chilli pepper samples[J].Anal Chim Acta,2012,731:40?48.
[14]Hu X,Cai Q,Fan Y,et al.Molecularly imprinted polymer coated solid-phase microextraction fibers for determination of Sudan I–IV dyes in hot chili powder and poultry feed samples[J].J Chromatogr A,2012,1219:39?46.
[15]Yang Y,Chen J,Shi YP.Determination of diethylstilbestrol in milk using carbon nanotube-reinforced hollow fiber solid-phase microextraction combined with high-performance liquid chromatography[J].Talanta,2012,97:222?228.
[16]Song XY,Shi YP,Chen J.Carbon nanotubes-reinforced hollow fibre solid-phase microextraction coupled with high performance liquid chromatography for the determination of carbamate pesticides in apples[J].Food Chem,2013,139(1):246?252.
[17]Souza-SilvaéA,Gionfriddo E,Pawliszyn J.A critical review of the state of the art of solid-phase microextraction of complex matrices II.Food analysis[J].Trac-Trend Anal Chem,2015,71:236?248.
[18]Saison D,De Schutter DP,Delvaux F,et al.Optimisation of a complete method for the analysis of volatiles involved in the flavour stability of beer by solid-phase microextraction in combination with gas chromatography and mass spectrometry[J].J Chromatogr A,2008,1190(1):342?349.
[19]Saison D,De Schutter DP,Delvaux F,et al.Determination of carbonyl compounds in beer by derivatisation and headspace solid-phase microextraction in combination with gas chromatography and mass spectrometry[J].J Chromatogr A,2009,1216(26):5061?5068.
[20]Carasek E,Cudjoe E,Pawliszyn J.Fast and sensitive method to determine chloroanisoles in cork using an internally cooled solid-phase microextraction fiber[J].J Chromatogr A,2007,1138(1):10?17.
[21]JeleńHH,Dziadas M,Majcher M.Different headspace solid phase microextraction–Gas chromatography/mass spectrometry approaches to haloanisoles analysis in wine[J].J Chromatogr A,2013,1313:185?193.
[22]Kataoka H,Lord HL,Pawliszyn J.Applications of solid-phase microextraction in food analysis[J].J Chromatogr A,2000,880(1):35?62.
[23]Bai Z,Pilote A,Sarker PK,et al.In vivo solid-phase microextraction with in vitro calibration:determination of off-flavor components in live fish[J].Anal Chem,2013,85(4):2328?2332.
[24]Gionfriddo E,Naccarato A,Sindona G,et al.A reliable solid phase microextraction-gas chromatography–triple quadrupole mass spectrometry method for the assay of selenomethionine and selenomethylselenocysteine in aqueous extracts:difference between selenized and not-enriched selenium potatoes[J].Anal Chim Acta,2012,747:58?66.
[25]Mirnaghi FS,Mousavi F,Rocha SM,et al.Automated determination of phenolic compounds in wine,berry,and grape samples using 96-blade solid phase microextraction system coupled with liquid chromatography–tandem mass spectrometry[J].J Chromatogr A,2013,1276:12?19.
[26]Stanimirova I,stün B,Cajka T,et al.Tracing the geographical origin of honeys based on volatile compounds profiles assessment using pattern recognition techniques[J].Food Chem,2010,118(1):171?176.
[27]Donato P,Quinto Tranchida P,Dugo P,et al.Rapid analysis of food products by means of high speed gas chromatography[J].J Sep Sci,2007,30(4):508?526.
[28]Blumberg LM,Klee MS.Method translation and retention time locking in partition GC[J].Anal Chem,1998,70(18):3828?3839.
[29]Mondello L,Casilli A,Tranchida PQ,et al.Evaluation of fast gas chromatography and gas chromatography–mass spectrometry in the analysis of lipids[J].J Chromatogr A,2004,1035(2):237?247.
[30]Mondello L,Tranchida PQ,Dugo P,et al.Rapid,micro-scale preparation and very fast gas chromatographic separation of cod liver oil fatty acid methyl esters[J].J Pharm Biom,2006,41(5):1566?1570.
[31]Mondello L,Casilli A,Tranchida PQ,et al.Fast enantiomeric analysis of a complex essential oil with an innovative multidimensional gas chromatographic system[J].J Chromatogr A,2006,1105(1):11?16.
[32]Tranchida PQ,Presti ML,Costa R,et al.High-throughput analysis of bergamot essential oil by fast solid-phase microextraction–capillary gas chromatography–flame ionization detection[J].J Chromatogr A,2006,1103(1):162?165.
[33]HercegováA,D?m?t?rováM,MatisováE,et al.Fast gas chromatography with solid phase extraction clean-up for ultratrace analysis of pesticide residues in baby food[J].J Chromatogr A,2005,1084(1):46?53.
[34]Kirchner M,MatisováE,Otrekal R,et al.Search on ruggedness of fast gas chromatography–mass spectrometry in pesticide residues analysis[J].J Chromatogr A,2005,1084(1):63?70.
[35]D?m?t?rováM,Kirchner M,MatisováE,et al.Possibilities and limitations of fast GC with narrow-bore columns[J].J Sep Sci,2006,29(8):1051?1063.
[36]HercegováA,D?m?t?rováM,Kru?licováD,et al.Comparison of sample preparation methods combined with fast gas chromatography–mass spectrometry for ultratrace analysis of pesticide residues in baby food[J].J Sep Sci,2006,29(8):1102?1109.
[37]Pursch M,Sun K,Winniford B,et al.Modulation techniques and applications in comprehensive two-dimensional gas chromatography(GC×GC)[J].Anal Bioanal Chem,2002,373(6):356?367.
[38]Ryan D,Watkins P,Smith J,et al.Analysis of methoxypyrazines in wine using headspace solid phase microextraction with isotope dilution and comprehensive two-dimensional gas chromatography[J].J Sep Sci,2005,28(9-10):1075?1082.
[39]Cardeal Z,De Souza P,Da Silva MG,et al.Comprehensive two-dimensional gas chromatography for fingerprint pattern recognition in cacha?a production[J].Talanta,2008,74(4):793?799.
[40]Friedrich JE,Acree TE.Gas chromatography olfactometry(GC/O)of dairy products[J].Int Dairy J,1998,8(3):235?241.
[41]Zhu S,Lu X,Ji K,et al.Characterization of flavor compounds in Chinese liquor Moutai by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry[J].Anal Chim Acta,2007,597(2):340?348.
[42]Bianchi F,Careri M,Conti C,et al.Comparison of comprehensive two‐dimensional gas chromatography‐time‐of flight mass spectrometry and gas chromatography-mass spectrometry for the qualitative characterisation of roasted barley by solid-phase microextraction[J].J Sep Sci,2007,30(4):527?533.
[43]Mondello L,Casilli A,Tranchida PQ,et al.Comprehensive multidimensional GC for the characterization of roasted coffee beans[J].J Sep Sci,2004,27(5?6):442?450.
[44]CˇAjka TD,Haj lovμJ,Cochran J,et al.Original Paper Solid phase microextraction–comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry for the analysis of honey volatiles[J].J Sep Sci,2007,30:534?546.
[45]Vaz-Freire LT,Da Silva MG,Freitas AC.Comprehensive two-dimensional gas chromatography for fingerprint pattern recognition in olive oils produced by two different techniques in Portuguese olive varieties Galega Vulgar,Cobran?osa e Carrasquenha[J].Anal Chim Acta,2009,633(2):263?270.
[46]Williams A,Ryan D,Guasca AO,et al.Analysis of strawberry volatiles using comprehensive two-dimensional gas chromatography with headspace solid-phase microextraction[J].J Chromatogr B,2005,817(1):97?107.
[47]O’mahony J,Clarke L,Whelan M,et al.The use of ultra-high pressure liquid chromatography with tandem mass spectrometric detection in the analysis of agrochemical residues and mycotoxins in food challenges and applications[J].J Chromatogr A,2013,1292:83?95.
[48]Whelan M,Kinsella B,Furey A,et al.Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography–tandem mass spectrometry with rapid polarity switching[J].J Chromatogr A,2010,1217(27):4612?4622.
[49]Leandro CC,Hancock P,Fussell RJ,et al.Comparison of ultra-performance liquid chromatography and high-performance liquid chromatography for the determination of priority pesticides in baby foods by tandem quadrupole mass spectrometry[J].J Chromatogr A,2006,1103(1):94?101.
[50]Duffy E,Rambaud L,Le Bizec B,et al.Determination of hormonal growth promoters in bovine hair:comparison of liquid chromatography–mass spectrometry and gas chromatography–mass spectrometry methods for estradiol benzoate and nortestosterone decanoate[J].Anal Chim Acta,2009,637(1):165?172.
[51]Van Poucke C,Van Vossel E,Van Peteghem C.Fractionation of free and conjugated steroids for the detection of boldenone metabolites in calf urine with ultra‐performance liquid chromatography/tandem mass spectrometry[J].Rapid Commun Mass Sp,2008,22(15):2324?2332.
[52]He XW,Ying Z,Jiang QW.Simultaneous analysis of nine estrogens in milk powder with ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry[J].Chin J Anal Chem,2011,39(9):1323?1328.
[53]Yang F,Liu Z,Lin Y,et al.Development an UHPLC-MS/MS method for detection ofβ-agonist residues in milk[J].Food Anal Method,2012,5(1):138?147.
[54]Shao B,Jia X,Zhang J,et al.Multi-residual analysis of 16β-agonists in pig liver,kidney and muscle by ultra performance liquid chromatography tandem mass spectrometry[J].Food Chem,2009,114(3):1115?1121.
[55]Zhang J,Shao B,Yin J,et al.Simultaneous detection of residues ofβ-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry[J].J Chromatogr B,2009,877(20):1915?1922.
[56]Nielen M,Lasaroms J,Essers M,et al.Multiresidue analysis of beta-agonists in bovine and porcine urine,feed and hair using liquid chromatography electrospray ionisation tandem mass spectrometry[J].Anal Bioanal Chem,2008,391(1):199?210.
[57]Zhang H,Ren Y,Bao X.Simultaneous determination of(fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography–tandem mass spectrometry[J].J Pharm Biom,2009,49(2):367?374.
[58]Lombardo-AgüíM,García-Campa?a AM,Gámiz-Gracia L,et al.Determination of quinolones of veterinary use in bee products by ultra-high performance liquid chromatography–tandem mass spectrometry using a Qu ECh ERS extraction procedure[J].Talanta,2012,93:193?199.
[59]Zhao XT,Lin QB,Song H,et al.Development of an immunoaffinity chromatography purification and ultra performance liquid chromatography tandem mass spectrometry method for determination of 12 sulfonamides in beef and milk[J].J Agric Food Chem,2011,59(18):9800?9805.
[60]She YX,Liu J,Wang J,et al.Determination of sulfonamides in bovine milk by ultra performance liquid chromatography combined with quadrupole mass spectrometry[J].Anal Lett,2010,43(14):2246?2256.
[61]Mcdonald M,Mannion C,Rafter P.A confirmatory method for the simultaneous extraction,separation,identification and quantification of Tetracycline,Sulphonamide,Trimethoprim and Dapsone residues in muscle by ultra-high-performance liquid chromatography–tandem mass spectrometry according to Commission Decision 2002/657/EC[J].J Chromatogr A,2009,1216(46):8110?8116.
[62]Zhang X,Xu H,Zhang H,et al.Simultaneous determination of albendazole and its metabolites in fish muscle tissue by stable isotope dilution ultra-performance liquid chromatography tandem mass spectrometry[J].Anal Bioanal Chem,2011,401(2):727?734.
[63]Xia X,Dong Y,Luo P,et al.Determination of benzimidazole residues in bovine milk by ultra-high performance liquid chromatography–tandem mass spectrometry[J].J Chromatogr B,2010,878(30):3174?3180.
[64]Hu T,Peng T,Li X-J,et al.Simultaneous determination of thirty non-steroidal anti-inflammatory drug residues in swine muscle by ultra-high-performance liquid chromatography with tandem mass spectrometry[J].J Chromatogr A,2012,1219:104?113.
[65]Mol HG,Plaza-Bola?os P,Zomer P,et al.Toward a generic extraction method for simultaneous determination of pesticides,mycotoxins,plant toxins,and veterinary drugs in feed and food matrixes[J].Anal Chem,2008,80(24):9450?9459.
[66]Herrmann A,Rosén J,Jansson D,et al.Evaluation of a generic multi-analyte method for detection of>100 representative compounds correlated to emergency events in 19 food types by ultrahigh-pressure liquid chromatography–tandem mass spectrometry[J].J Chromatogr A,2012,1235:115?124.
[67]Zhan J,Yu XJ,Zhong YY,et al.Generic and rapid determination of veterinary drug residues and other contaminants in raw milk by ultra performance liquid chromatography–tandem mass spectrometry[J].J Chromatogr B,2012,906:48?57.
[68]Fanali C,Dugo L,Dugo P,et al.Capillary-liquid chromatography(CLC)and nano-LC in food analysis[J].Trac-Trend Anal Chem,2013,52:226?238.
[69]Fanali C,Dugo L,D'orazio G,et al.Analysis of anthocyanins in commercial fruit juices by using nano-liquid chromatography‐electrospray‐mass spectrometry and high‐performance liquid chromatography with UV-vis detector[J].J Sep Sci,2011,34(2):150?159.
[70]Hu F,Deng C,Liu Y,et al.Quantitative determination of chlorogenic acid in Honeysuckle using microwave-assisted extraction followed by nano-LC-ESI mass spectrometry[J].Talanta,2009,77(4):1299?1303.
[71]Hughey CA,Wilcox B,Minardi CS,et al.Capillary liquid chromatography–mass spectrometry for the rapid identification and quantification of almond flavonoids[J].J Chromatogr A,2008,1192(2):259?265.
[72]Xie W,Mirocha CJ,Chen J.Detection of two naturally occurring structural isomers of partially hydrolyzed fumonisin B1 in corn by on-line capillary liquid chromatography-fast atom bombardment mass spectrometry[J].J Agric Food Chem,1997,45(4):1251?1255.
[73]Aqai P,Peters J,Gerssen A,et al.Immunomagnetic microbeads for screening with flow cytometry and identification with nano-liquid chromatography mass spectrometry of ochratoxins in wheat and cereal[J].Anal Bioanal Chem,2011,400(9):3085?3096.
[74]Kruve A,Haapala M,Saarela V,et al.Feasibility of capillary liquid chromatography–microchip-atmospheric pressure photoionization–mass spectrometry for pesticide analysis in tomato[J].Anal Chim Acta,2011,696(1):77?83.
[75]Onisko BC,Tambling DR,Gorder GW,et al.Identification of fonofos metabolites in Latuca sativa,Beta vulgaris,and Triticum aestivum by packed capillary flow fast atom bombardment tandem mass spectrometry[J].J Agric Food Chem,2002,50(7):1922?1928.
[76]Halvorsen B,Thomsen C,Greibrokk T,et al.Determination of fenpyroximate in apples by supercritical fluid extraction and packed capillary liquid chromatography with UV detection[J].J Chromatogr A,2000,880(1):121?128.
[77]Rosales-Conrado N,León-González M,Pérez-Arribas L,et al.Capillary liquid chromatography of chlorophenoxy acid herbicides and their esters in apple juice samples after preconcentration on a cation exchanger based on polydivinylbenzene-N-vinylpyrrolidone[J].J Chromatogr A,2005,1076(1):202?206.
[78]Lucas-Delfa M,Pérez-Arribas L,Navarro-Villoslada F,et al.Determination of chlorophenoxy acid and dicamba herbicide residues by capillary reversed-phase liquid chromatography[J].J Liquid Chromatogr Relat Technol,2000,23(5):755?767.
[79]Yakovleva J,Davidsson R,Bengtsson M,et al.Microfluidic enzyme immunosensors with immobilised protein A and G using chemiluminescence detection[J].Biosens Bioelectron,2003,19(1):21?34.
[80]D’orazio G,Cifuentes A,Fanali S.Chiral nano-liquid chromatography–mass spectrometry applied to amino acids analysis for orange juice profiling[J].Food Chem,2008,108(3):1114?1121.
[81]Domínguez-Vega E,Crego AL,Lomsadze K,et al.Enantiomeric separation of FMOC-amino acids by nano-LC and CEC using a new chiral stationary phase,cellulose tris(3-chloro-4-methylphenylcarbamate)[J].Electrophoresis,2011,32(19):2700?2707.
[82]Guillén-Casla V,Rosales-Conrado N,León-González M,et al.Determination of serotonin and its precursors in chocolate samples by capillary liquid chromatography with mass spectrometry detection[J].J Chromatogr A,2012,1232:158?165.
[83]Rizzello CG,Coda R,De Angelis M,et al.Long-term fungal inhibitory activity of water-soluble extract from Amaranthus spp.seeds during storage of gluten-free and wheat flour breads[J].Int J Food Microbiol,2009,131(2):189?196.
[84]Coda R,Rizzello CG,Nigro F,et al.Long-term fungal inhibitory activity of water-soluble extracts of Phaseolus vulgaris cv.Pinto and sourdough lactic acid bacteria during bread storage[J].Appl Environ Microb(AEM),2008,74(23):7391?7398.
[85]Rizzello CG,De AM,Di CR,et al.Highly efficient gluten degradation by lactobacilli and fungal proteases during food processing:new perspectives for celiac disease[J].Appl Environ Microb(AEM),2007,73(14):4499?4507.
[86]De AM,Rizzello CG,Fasano A,et al.VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue probiotics and gluten intolerance[J].BBA-Mol Basis Dis,2006,1762(1):80?93.
[87]Gebriel M,Uleberg KE,Larssen E,et al.Cod(Gadus morhua)muscle proteome cataloging using 1D-PAGE protein separation,nano-liquid chromatography peptide fractionation,and linear trap quadrupole(LTQ)mass spectrometry[J].J Agric Food Chem,2010,58(23):12307?12312.
[88]Sawasdipuksa N,Sumner LW,Lei Z,et al.Proteome analysis of Pithecellobium dulce seeds using two-dimensional gel electrophoresis and tandem mass spectrometry[J].J Sci Food Agr,2009,89(8):1284?1291.
[89]Kwon SW.Profiling of soluble proteins in wine by nano-high-performance liquid chromatography/tandem mass spectrometry[J].J Agric Food Chem,2004,52(24):7258?7263.
[90]Bianco L,Lopez L,Scalone AG,et al.Strawberry proteome characterization and its regulation during fruit ripening and in different genotypes[J].J Prot,2009,72(4):586?607.
[91]Bernal JL,Martín MT,Toribio L.Supercritical fluid chromatography in food analysis[J].J Chromatogr A,2013,1313:24?36.
[92]Rocco A,Aturki Z,Fanali S.Chiral separations in food analysis[J].Trac-Trend Anal Chem,2013,52:206?225.
[93]Tranchida PQ,Donato P,Cacciola F,et al.Potential of comprehensive chromatography in food analysis[J].Trac-Trend Anal Chem,2013,52:186?205.
[94]Mondello L,Tranchida P,Stanek V,et al.Silver-ion reversed-phase comprehensive two-dimensional liquid chromatography combined with mass spectrometric detection in lipidic food analysis[J].J Chromatogr A,2005,1086(1):91?98.
[95]Dugo P,Kumm T,Crupi M,et al.Comprehensive two-dimensional liquid chromatography combined with mass spectrometric detection in the analyses of triacylglycerols in natural lipidic matrixes[J].J Chromatogr A,2006,1112(1):269?275.
[96]Dugo P,Kumm T,Lo Presti M,et al.Determination of triacylglycerols in donkey milk by using high performance liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry[J].J Sep Sci,2005,28(9?10):1023?1030.
[97]Dugo P,Kumm T,Chiofalo B,et al.Separation of triacylglycerols in a complex lipidic matrix by using comprehensive two-dimensional liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometric detection[J].J Sep Sci,2006,29(8):1146?1154.
[98]Van Der Klift EJ,Vivó-Truyols G,Claassen FW,et al.Comprehensive two-dimensional liquid chromatography with ultraviolet,evaporative light scattering and mass spectrometric detection of triacylglycerols in corn oil[J].J Chromatogr A,2008,1178(1):43?55.
[99]Mondello L,Beccaria M,Donato P,et al.Comprehensive two-dimensional liquid chromatography with evaporative light-scattering detection for the analysis of triacylglycerols in Borago officinalis[J].J Sep Sci,2011,34(6):688?692.
[100]Dugo P,Fawzy N,Cichello F,et al.Stop-flow comprehensive two-dimensional liquid chromatography combined with mass spectrometric detection for phospholipid analysis[J].J Chromatogr A,2013,1278:46?53.
[101]Li M,Yang L,Bai Y,et al.Analytical methods in lipidomics and their applications[J].Anal Chem,2013,86(1):161?175.
[102]Li M,Tong X,Lv P,et al.A not-stop-flow online normal-/reversed-phase two-dimensional liquid chromatography–quadrupole time-of-flight mass spectrometry method for comprehensive lipid profiling of human plasma from atherosclerosis patients[J].J Chromatogr A,2014,1372:110?119.
[103]Li M,Feng B,Liang Y,et al.Lipid profiling of human plasma from peritoneal dialysis patients using an improved 2D(NP/RP)LC-QTo F MS method[J].Anal Bioanal Chem,2013,405(21):6629?6638.
[104]Nie H,Liu R,Yang Y,et al.Lipid profiling of rat peritoneal surface layer by an online NP/RP 2D LC-QTo F-MS system[J].J Lipid Res,2010,51:2833?2844.
[105]De Koning S,Janssen HG,Van Deursen M,et al.Automated on-line comprehensive two-dimensional LC×GC and LC×GC-To F MS:Instrument design and application to edible oil and fat analysis[J].J Sep Sci,2004,27(5?6):397?409.
[106]De KS,Janssen HG,Udo AT.Characterization of triacylglycerides from edible oils and fats using single and multidimensional techniques[J].LC GC EUR,2006,19(11):590?600.
[107]Fran?ois I,Sandra P.Comprehensive supercritical fluid chromatography×reversed phase liquid chromatography for the analysis of the fatty acids in fish oil[J].J Chromatogr A,2009,1216(18):4005?4012.
[108]Fran?ois I,Pereira Ad S,Sandra P.Considerations on comprehensive and off-line supercritical fluid chromatography reversed-phase liquid chromatography for the analysis of triacylglycerols in fish oil[J].J Sep Sci,2010,33(10):1504?1512.
[109]Wang X,Wang S,Cai Z.The latest developments and applications of mass spectrometry in food-safety and quality analysis[J].Trac-Trend Anal Chem,2013,52:170?185.
[110]Senyuva HZ,G?kmen V,Sarikaya EA.Future perspectives in Orbitrap?-high-resolution mass spectrometry in food analysis:a review[J].Food Addit Contam A,2015,32(10):1568?1606.
[111]Gómez-Pérez ML,Plaza-Bola?os P,Romero-González R,et al.Comprehensive qualitative and quantitative determination of pesticides and veterinary drugs in honey using liquid chromatography–orbitrap high resolution mass spectrometry[J].J Chromatogr A,2012,1248:130?138.
[112]Monaci L,De Angelis E,Visconti A.Determination of deoxynivalenol,T-2 and HT-2 toxins in a bread model food by liquid chromatography–high resolution-Orbitrap-mass spectrometry equipped with a high-energy collision dissociation cell[J].J Chromatogr A,2011,1218(48):8646?8654.
[113]Mol HG,Zomer P,De Koning M.Qualitative aspects and validation of a screening method for pesticides in vegetables and fruits based on liquid chromatography coupled to full scan high resolution(Orbitrap)mass spectrometry[J].Anal Bioanal Chem,2012,403(10):2891?2908.
[114]Yeboah SO,Mitei YC,Ngila JC,et al.Compositional and structural studies of the major and minor components in three cameroonian seed oils by GC–MS,ESI-FTICR-MS and HPLC[J].J Am Oil Chem Soc,2011,88(10):1539?1549.
[115]Chang C,Xu G,Bai Y,et al.Online coupling of capillary electrophoresis with direct analysis in real time mass spectrometry[J].Anal Chem,2012,85(1):170?176.
[116]Shen Y,Van Beek TA,Claassen FW,et al.Rapid control of Chinese star anise fruits and teas for neurotoxic anisatin by direct analysis in real time high resolution mass spectrometry[J].J Chromatogr A,2012,1259:179?186.
[117]FarréM,PicóY,BarcelóD.Direct peel monitoring of xenobiotics in fruit by direct analysis in real time coupled to a linear quadrupole ion trap–orbitrap mass spectrometer[J].Anal Chem,2013,85(5):2638?2644.
[118]Nielen M,Hooijerink H,Zomer P,et al.Desorption electrospray ionization mass spectrometry in the analysis of chemical food contaminants in food[J].Trac-Trend Anal Chem,2011,30(2):165?180.
[119]García-Reyes JF,Jackson AU,Molina-DíAz A,et al.Desorption electrospray ionization mass spectrometry for trace analysis of agrochemicals in food[J].Anal Chem,2008,81(2):820?829.
[120]Galhena AS,Harris GA,Kwasnik M,et al.Enhanced direct ambient analysis by differential mobility-filtered desorption electrospray ionization-mass spectrometry[J].Anal Chem,2010,82(22):9159?9163.
[121]Li X,Hu B,Ding J,et al.Rapid characterization of complex viscous samples at molecular levels by neutral desorption extractive electrospray ionization mass spectrometry[J].Nat Protoc,2011,6(7):1010?1025.