硝基咪唑杂环药物化学研究进展
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摘要
硝基咪唑是一类特殊结构的杂环,五元芳香杂环咪唑与硝基的共缀使其衍生物呈现广泛的应用潜力,在药物、人工诊断剂与人工探针等相关领域研究异常活跃,尤其是在医药方面作为人工合成的化学药物已在临床中广泛用于抗癌、抗菌、抗寄生虫等,备受关注.本文结合本课题组相关研究,参考国内外近期文献,系统地综述了硝基咪唑类化合物在药物化学领域的研究与应用,包括抗肿瘤、抗细菌、抗真菌、抗寄生虫、抗结核、抗高血压以及作为人工诊断剂与病理探针、超分子基体等领域的当前现状,展望了其未来可能的发展趋势.希望该评述能为硝基咪唑类杂环化合物的多用途开发提供有益的指导.
Nitroimidazoles are a class of structurally special heterocycles. The combination of five-membered aromatic heterocyclic imidazole and nitro group makes their derivatives to possess a wide variety of potential applications, and relevant researches of nitroimidazoles as drugs, artificial diagnostics, pathological probes and so on are quite active. In particular, nitroimidazoles as artificially synthetic chemical drugs have been widely used in the clinic for anticancers,antimicrobials, antiparasites etc.. Combining with our work and literatures in recent years, this work systematically reviewed the current researches and applications of nitroimidazole compounds in medicinal chemistry including antitumor, antibacterial, antifungal, antiparasitic, antitubercular, antihypertensive drugs as well as artificial diagnostics and pathological probes, supramolecular blocks. The foreseeable development trends were also prospected. This comprehensive review may provide a beneficial guide in the development of nitroimidazole heterocyclic compounds for multipurpose applications.
Nitroimidazoles are a class of structurally special heterocycles. The combination of five-membered aromatic heterocyclic imidazole and nitro group makes their derivatives to possess a wide variety of potential applications, and relevant researches of nitroimidazoles as drugs, artificial diagnostics, pathological probes and so on are quite active. In particular, nitroimidazoles as artificially synthetic chemical drugs have been widely used in the clinic for anticancers,antimicrobials, antiparasites etc.. Combining with our work and literatures in recent years, this work systematically reviewed the current researches and applications of nitroimidazole compounds in medicinal chemistry including antitumor, antibacterial, antifungal, antiparasitic, antitubercular, antihypertensive drugs as well as artificial diagnostics and pathological probes, supramolecular blocks. The foreseeable development trends were also prospected. This comprehensive review may provide a beneficial guide in the development of nitroimidazole heterocyclic compounds for multipurpose applications.
引文
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