2008～2011年新生儿血培养致病菌分布与耐药性变迁

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英文篇名：Pathogenic bacteria distribution of neonatal blood culture and drug resistance variation from the year 2008 to 2011 作者：于路妹 英文作者：YU Lu-mei Lingui People's Hospital,Lingui 541100,China 关键词：新生儿 ; 血培养 ; 致病菌 ; 耐药性 英文关键词：neonate;blood culture;pathogenic bacteria;drug resistance 中文刊名：GLYX 英文刊名：Acta Medicinae Sinica 机构：临桂县人民医院; 出版日期：2013-02-15 出版单位：华夏医学 年：2013 期：v.26 语种：中文; 页：GLYX201301035 页数：4 CN：01 ISSN：45-1236/R 分类号：107-110

摘要

目的:了解新生儿血培养致病菌的构成比与耐药性的变迁,为临床抗生素的合理使用提供依据。方法:对近4年的新生儿血培养结果进行统计、分析。致病菌培养采用法国梅里埃公司的Bact/A-lert-120全自动血培养系统进行。药敏试验采用K-B法。结果:致病菌的构成比与主要致病菌的耐药性均具有不同程度的变迁。对革兰阴性杆菌敏感性较高的为亚胺培南、氨苄西林/舒巴坦和美罗培南;耐药性最高的为哌啦西林。对葡萄球菌敏感性最高的为万古霉素、环丙沙星、左氧氟沙星和克林霉素;敏感性最低的为青霉素。结论:引起新生儿败血症的致病菌从2008年的肠杆菌科为主改变为2011年的以金黄色葡萄球菌为主要致病菌。
        Objective:To learn the pathogenic bacteria distribution of neonatal blood culture and drug resistance variation for providing basis for clinical rational use of antibiotics.Methods:The recent 4-year neonatal blood culture results were statistically analyzed.The French company Merry Ella Bact/Alert-20 automatic blood culture system was adopted to the pathogenic bacteria culture.And K-B method was adopted to perform drug sensitive test.Results:There was a different degree of change for the proportion of the pathogenic bacteria composition and drug resistance.The much higher sensitive drugs to gram-negative bacilli(GNB) are imipenem,ampicillin/sulbactam and meropenem;while the highest drug resistance is piperacillin.The highest sensitive drugs to staphylococcus are vancomycin,ciprofloxacin,levofloxacin and clindamycin;while the lowest sensitive drug is penicillin.Conclusion:The pathogenic bacteria to cause the neonatal sepsis changed from the chief enterobacteriaceae in 2008 to the chief staphylococcus aureus.

引文

[1]施新颜,沈强.新生儿血液培养细菌分布与耐药性变迁分析[J].中国优生与遗传杂志,2009,17(6):81-85.
    [2]商鸣宇,李京明,高元明,等.血培养检出病原菌的变迁及经验性应用抗菌药物临床探讨[J].中华医院感染学杂志,2010,20(15):2291-2293.
    [3]郑姬,张晓兵,董彦芳,等.2006～2008年血培养主要病原菌的分布与耐药性变迁[J].中华医院感染学杂志,2009,19(14):1868-1871.
    [4]孟祥红,朱蕾,杨彩娥,等.2008～2010年血培养细菌分布与耐药性变迁[J].军医进修学院学报,2011,32(10):986-989.