细辛脑的临床前毒性研究进展
摘要
<正>几个世纪以来,在印度和中国传统文献记载中,菖蒲属植物被当作草药单独使用或与其他草药联合应用~([1])。其中石菖蒲是著名的中国本土药用植物,在中国药典已明确记录。菖蒲属物种已被记载可用于治疗呼吸系统疾病和各种神经系统疾病,如癫痫和认知障碍等~([2-3])。α-细辛脑和β-细辛脑是存在于菖蒲属植物如石菖蒲的根状茎中,具有生物活性的一类化学物质,其含量和比例的变化取决于菖蒲属植物类别和产地~([4])。有研究表明,α-和β-细辛脑具有广泛的药理活性,包括抗
引文
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[33]Chilmonczyk Z,Siluk D,Kaliszan R,et al.New chemical structures of hypolipidemic and antiplatelet activity[J].Pure Appl Chem,2001,73(9):1445-1458.
[34]Marczewska J,Drozd E,Anuszewska E,et al.Assessment of the genotoxic activity of alpha-asarone and its derivatives in the comet assay[J].Acta Poloniae Pharm,2013,70(2):349-354.
[35]Cassani-Galindo M,Madrigal-Bujaidar E,Chamorro G.In vitro genotoxic evaluation of threeα-asarone analogues[J].Toxicol Vitro,2005,19(4):547-552.
[2]Huang C,Li WG,Zhang XB,et al.α-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABAreceptors[J].Neuropharmacol,2013,65(5):1-11.
[3]Wang ZJ,Levinson SR,Sun L,et al.Identification of both GABAA receptors and voltage-activated Na+channels as molecular targets of anticonvulsantα-asarone[J].Front Pharmacol,2014,5:40.
[4]Chamorro G,Salazar M,Favila L,et al.Pharmacology and toxicology of Spirulina alga[J].Rev Invest Clin,1996,48(5):389-399.
[5]Scientific Committee on Food(SCF).Opinion of the scientific committee on food on the presence ofβ-asarone in flavourings and other food ingredients with flavouring properties[C].European Commission Health&Consumer Protection Directorate-General,Brussel,2002:1-15.
[6]JECFA.Joint FAO/WHO Expert committee on food additives.Monograph onβ-Asarone DS.IPCS INCHEM[EB/OL].(2008-01-15).http://www.inchem.org/documents/jecfa/jecmono/v16je04.htm.
[7]Feng XL,Yu Y,Qin DP,et al.Acorus linnaeus:a review of traditional uses,phytochemistry and neuropharmacology[J].Rsc Advances,2014,5(7):5173-5182.
[8]Zhang Q,Ma WC,Li H.Asarone injection in treating respiratory disease:a meta-analysis[J].Chin J Evi Med,2010,10(10):1174-1181.
[9]Chen QX,Miao JK,Li C,et al.Anticonvulsant activity of acute and chronic treatment with a-asarone from acorus gramineus in seizure models[J].Biol Pharm Bull,2013,36(1):23-30.
[10]Morales-Ramírez P,Madrigal-Bujaidar E,MercaderMartínez J,et al.Sister-chromatid exchange induction produced by in vivo and in vitro exposure to alpha-asarone[J].Mutat Res,1992,279(4):269-273.
[11]Liu L,Wang J,Shi L,et al.Beta-Asarone induces senescence in colorectal cancer cells by inducing lamin B1expression[J].Phytomedicine,2018,20(6):512-520.
[12]Wiseman RW,Miller EC,Miller JA,et al.Structureactivity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/He J F1 mice[J].Cancer Res,1987,22(3):319.
[13]López ML,Hernández A,Chamorro G,et al.alphaAsarone toxicity in long-term cultures of adult rat hepatocytes[J].Planta Medica,1993,59(2):115-120.
[14]Manikandan S,Devi RS.Antioxidant property of alphaasarone against noise-stress-induced changes in different regions of rat brain[J].Pharmacol Res,2005,52(6):467-474.
[15]Patel DN,Han KH,Tan LL,et al.Hepatotoxic potential of asarones:in vitro evaluation of hepatotoxicity and quantitative determination in herbal products[J].Front Pharmacol,2015,6:25.
[16]Maurici D,Aardema M,Corvi R,et al.Establishment of timetables for the phasing out of animal experiments for cosmetics[EB/OL].(2004-04-30).https://ec.europa.eu/consumes/sectors/cosmetics/files/doc/antest/(5)chapter3/7 genotex-mutagen.
[17]Berg K,Bischoff R,Stegmüller S,et al.Comparative investigation of the mutagenicity of propenylic and allylic asarone isomers in the Ames fluctuation assay[J].Mutagenesis,2016,31(4):443-451.
[18]Cassani-Galindo M,Madrigal-Bujaidar E,Chamorro G,et al.In vitro genotoxic evaluation of three alpha-asarone analogues[J].Toxicol Vitro,2005,19(4):547-52.
[19]Hasheminejad G,Caldwell J.Genotoxicity of the alkenylbenzenesα-andβ-asarone,myristicin and elemicin as determined by the UDS assay in cultured rat hepatocytes[J].Food Chem Toxicol,1994,32(3):223-231.
[20]Haupenthal S,Vallicotti S,Hemgesberg M,et al.The alkaline comet assay as a method to investigate the DNAstrand breaking effect of phenylpropanoids in mammalian cells[C].Conference Abstract:ICAW 2015-11th International Comet Assay Workshop.
[21]Divyasree S.Radioprotection byα-asarone:prevention of genotoxicity and hematopoietic injury in mammalian organism[J].Mutat Res,2011,722(1):62-68.
[22]Asha Devi S,Babu,S,et al.In vivo genotoxic studies ofβ-Asarone in mice bone marrow[J].Int J Drug Dev Res,2014,6(3):128-132.
[23]Cai Q,Li Y,Mao J,et al.Neurogenesis-promoting natural productα-asarone modulates morphological dynamics of activated microglia[J].Front Cell Neurosci,2016,10:280.
[24]Chamorro G,Salazar M,Tamariz J,et al.Dominant lethal study of alpha-asarone in male and female mice after subchronic treatment[J].Phytotherapy Res Ptr,2015,13(4):308-311.
[25]Jimenez LL,Chamorro GG,Salazar MM,et al.Teratogenic evaluation of alpha-asarone in the rat[J].Ann Pharm Fr,1988,46(3):179-83.
[26]Salazar M,Salazar S,Ulloa V,et al.Teratogenic action of alpha-asarone in the mouse.Toxicol Clin Exp,1992,12(3):149-154.
[27]Cartus AT,Schrenk D.Metabolism of the carcinogen alpha-asarone in liver microsomes[J].Food Chem Toxicol,2016,87(9):103-112.
[28]Unger P,Melzig MF.Comparative study of the cytotoxicity and genotoxicity of alpha-and beta-asarone[J].Sci Pharm,2012,80(3):663-668.
[29]Hasheminejad G,Caldwell J.Genotoxicity of the alkenylbenzenes alpha-and beta-asarone,myristicin and elimicin as determined by the UDS assay in cultured rat hepatocytes[J].Food Chem Toxicol,1994,32(3):223-231.
[30]Oprean R,Tamas M,Roman L.Comparison of GC-MSand TLC techniques for asarone isomers determination[J].J Pharm Biomed Anal,1998,18(1/2):227-234.
[31]Berg K,Esselen M,Schrenk D.Evaluation of the mutagenic potential of the three asarone isomers[J].Toxicol Lett,2014,229:S171.
[32]Karwicka E,Marczewska J,Elzbieta A,et al.Genotoxicity ofα-asarone analogues[J].Bioorg Med Chem,2008,16(11):6069-6074.
[33]Chilmonczyk Z,Siluk D,Kaliszan R,et al.New chemical structures of hypolipidemic and antiplatelet activity[J].Pure Appl Chem,2001,73(9):1445-1458.
[34]Marczewska J,Drozd E,Anuszewska E,et al.Assessment of the genotoxic activity of alpha-asarone and its derivatives in the comet assay[J].Acta Poloniae Pharm,2013,70(2):349-354.
[35]Cassani-Galindo M,Madrigal-Bujaidar E,Chamorro G.In vitro genotoxic evaluation of threeα-asarone analogues[J].Toxicol Vitro,2005,19(4):547-552.