New phenylpyridone derivatives from the Penicillium sumatrense GZWMJZ-313,a fungal endophyte of Garcinia multiflora

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英文篇名：New phenylpyridone derivatives from the Penicillium sumatrense GZWMJZ-313,a fungal endophyte of Garcinia multiflora 作者：Yanchao ; Xu ; Liping ; Wang ; Guoliang ; Zhu ; Mingxing ; Zuo ; Qianyu ; Gong ; Wenwen ; He ; Mingpeng ; Li ; Chunmao ; Yuan ; Xiaojiang ; Hao ; Weiming ; Zhu 英文作者：Yanchao Xu;Liping Wang;Guoliang Zhu;Mingxing Zuo;Qianyu Gong;Wenwen He;Mingpeng Li;Chunmao Yuan;Xiaojiang Hao;Weiming Zhu;State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University;School of Pharmacuetical Sciences,Guizhou Medical University;Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences;Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China; 英文关键词：Penicillium sumatrense;;Garcinia multiflora;;Pyridones;;Antibacterial activities;;Endophytic fungi 中文刊名：FXKB 英文刊名：中国化学快报(英文版) 机构：State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University;School of Pharmacuetical Sciences,Guizhou Medical University;Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences;Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China; 出版日期：2019-02-15 出版单位：Chinese Chemical Letters 年：2019 期：v.30 基金：financially supported by the 100 Leading Talents of Guizhou Province (fund for W. Zhu and X. Hao);; the Science and Technology Project of Guizhou (No. QKHT Z-20144007);; the Academician Workstation of Guizhou (No. QKH YSZ2015-4009) 语种：英文; 页：FXKB201902037 页数：4 CN：02 ISSN：11-2710/O6 分类号：181-184

摘要

Citridones E-G (1-3), three new phenylpyridone derivatives together with two known curvularins (4 and 5) were isolated from the solid culture of the endophytic fungus Penicillium sumatrense GZWMJZ-313 in Garcinia multiflora. The structures of new compounds were determined in the light of spectroscopic data,X-ray and ECD calculation. Compounds 1 and 3 are racemates, while compound 2 is optically pure.Compounds 1 and 4 showed antibacterial and antifungal activities against Staphylococcus aureus,Pseudomonas aeruginosa, Clostridium perfringens, Escherichia coli and Candida albicans with MIC values ranging from 8 μg/mL to 64 μg/mL.
        Citridones E-G (1-3), three new phenylpyridone derivatives together with two known curvularins (4 and 5) were isolated from the solid culture of the endophytic fungus Penicillium sumatrense GZWMJZ-313 in Garcinia multiflora. The structures of new compounds were determined in the light of spectroscopic data,X-ray and ECD calculation. Compounds 1 and 3 are racemates, while compound 2 is optically pure.Compounds 1 and 4 showed antibacterial and antifungal activities against Staphylococcus aureus,Pseudomonas aeruginosa, Clostridium perfringens, Escherichia coli and Candida albicans with MIC values ranging from 8 μg/mL to 64 μg/mL.

引文

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