Combining anti-inflammatory and unfolding protein responses to fight stroke
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摘要
<正>This perspective shows an attempt to obtain synergy effects to fight ischemic stroke by combining agents acting on two different homeostatic mechanisms:inflammation and unfolded protein response(Anuncibay-Soto et al.,2018).Different pharmacological approaches have been assayed to alleviate cerebrovascular accident(stroke),which represents one of the most devastating diseases in the elderly.There are two main types of cerebrovascular accidents:ischemic and
引文
Anuncibay-Soto B,Pérez-Rodríguez D,Santos-Galdiano M,Font E,Regueiro-Purri?os M,Fernández-López A(2016)Post-ischemic salubrinal treatment results in a neuroprotective role in global cerebral ischemia.JNeurochem 138:295-306.
Anuncibay-Soto B,Pérez-Rodriguez D,Santos-Galdiano M,Font-Belmonte E,Ugidos IF,Gonzalez-Rodriguez P,Regueiro-Purri?os M,Fernández-López A(2018)Salubrinal and robenacoxib treatment after global cerebral ischemia.Exploring the interactions between ER stress and inflammation.Biochem Pharmacol 151:26-37.
Bai J,Lyden PD(2015)Revisiting cerebral postischemic reperfusion injury:new insights in understanding reperfusion failure,hemorrhage,and edema.Int J Stroke 10:143-152.
Cairns JA(2007)The coxibs and traditional nonsteroidal anti-inflammatory drugs:a current perspective on cardiovascular risks.Can J Cardiol 23:125-131.
Candelario-Jalil E,González-Falcón A,García-Cabrera M,Alvarez D,Al-Dalain S,Martínez G,León OS,Springer JE(2003)Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia.J Neurochem 86:545-555.
Fiebich BL,Akter S,Akundi RS(2014)The two-hit hypothesis for neuroinflammation:role of exogenous ATP in modulating inflammation in the brain.Front Cell Neurosci 8:260.
Hasnain SZ,Lourie R,Das I,Chen AC,McGuckin MA(2012)The interplay between endoplasmic reticulum stress and inflammation.Immunol Cell Biol90:260-270.
Kumar R,Krause GS,Yoshida H,Mori K,DeGracia DJ(2003)Dysfunction of the unfolded protein response during global brain ischemia and reperfusion.J Cereb Blood Flow Metab 23:462-471.
Liang D,Bhatta S,Gerzanich V,Simard JM(2007)Cytotoxic edema:mechanisms of pathological cell swelling.Neurosurg Focus 22:E2.
Nour M,Scalzo F,Liebeskind DS(2013)Ischemia-reperfusion injury in stroke.Interv Neurol 1:185-199.
Patrono C(2016)Cardiovascular effects of nonsteroidal anti-inflammatory drugs.Curr Cardiol Rep 18:25.
Roumie CL,Mitchel EF Jr,Kaltenbach L,Arbogast PG,Gideon P,Griffin MR(2008)Nonaspirin NSAIDs,cyclooxygenase 2 inhibitors,and the risk for stroke.Stroke 39:2037-2045.
Anuncibay-Soto B,Pérez-Rodriguez D,Santos-Galdiano M,Font-Belmonte E,Ugidos IF,Gonzalez-Rodriguez P,Regueiro-Purri?os M,Fernández-López A(2018)Salubrinal and robenacoxib treatment after global cerebral ischemia.Exploring the interactions between ER stress and inflammation.Biochem Pharmacol 151:26-37.
Bai J,Lyden PD(2015)Revisiting cerebral postischemic reperfusion injury:new insights in understanding reperfusion failure,hemorrhage,and edema.Int J Stroke 10:143-152.
Cairns JA(2007)The coxibs and traditional nonsteroidal anti-inflammatory drugs:a current perspective on cardiovascular risks.Can J Cardiol 23:125-131.
Candelario-Jalil E,González-Falcón A,García-Cabrera M,Alvarez D,Al-Dalain S,Martínez G,León OS,Springer JE(2003)Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia.J Neurochem 86:545-555.
Fiebich BL,Akter S,Akundi RS(2014)The two-hit hypothesis for neuroinflammation:role of exogenous ATP in modulating inflammation in the brain.Front Cell Neurosci 8:260.
Hasnain SZ,Lourie R,Das I,Chen AC,McGuckin MA(2012)The interplay between endoplasmic reticulum stress and inflammation.Immunol Cell Biol90:260-270.
Kumar R,Krause GS,Yoshida H,Mori K,DeGracia DJ(2003)Dysfunction of the unfolded protein response during global brain ischemia and reperfusion.J Cereb Blood Flow Metab 23:462-471.
Liang D,Bhatta S,Gerzanich V,Simard JM(2007)Cytotoxic edema:mechanisms of pathological cell swelling.Neurosurg Focus 22:E2.
Nour M,Scalzo F,Liebeskind DS(2013)Ischemia-reperfusion injury in stroke.Interv Neurol 1:185-199.
Patrono C(2016)Cardiovascular effects of nonsteroidal anti-inflammatory drugs.Curr Cardiol Rep 18:25.
Roumie CL,Mitchel EF Jr,Kaltenbach L,Arbogast PG,Gideon P,Griffin MR(2008)Nonaspirin NSAIDs,cyclooxygenase 2 inhibitors,and the risk for stroke.Stroke 39:2037-2045.