摘要
目的探讨年轻妇女宫颈癌的发病趋势、病因、临床病理特征、治疗及预后等情况。方法对40例年轻子宫颈癌患者的临床资料进行预后相关影响因素分析。结果年轻女性宫颈癌临床表现主要为接触性阴道出血,单因素分析显示,肿瘤直径、FIGO分期、病理类型、淋巴结转移与预后有关,均有统计学意义(P<0.05),分化程度、术后或术前是否放化疗对预后的影响均无统计学意义(P<0.05)。Cox回归分析结果显示临床分期、淋巴结转移更是影响预后的独立高危因素。结论年轻宫颈癌发病率较高,年轻宫颈癌临床期别早、淋巴结转移率高,有其独特的临床与病理学特征,其不良生物学特征对患者的预后是有影响的。建议对年轻妇女应加强普查和防治。
引文
[1]李巍,马慧娟,鲍俊兰,等.年轻妇女子宫颈癌52例临床分析[J].中国妇幼保健,2007,22(9):1276.
[2]Bielska-Lasota M,Krynicki R,Rabczenko D.Survival of cervical cancer patients in selected regions of Poland in1990-1996,in relation to some prognostic factors[J].Przegl Epidemiol,2004,58(3):523
[3]Bulk S,Visser O,Rozen daal L,et al.Cervical cancer in the Nether lands1989-1998:decrease of squamous cell carcinoma in older women,increase of adenocarcinoma in younger w omen[J].Cance,2005,113(6):1005-1009.
[4]Acharki A,Sahraoui S,BeniderA,et al.Cancer of the uterinecervix in young women:aretrospective study of337cases[J].Bull Cancer,1997,84(4):373-378.
[5]Ho CM,Chien TY,Huang SH,et al.Multivariate analysis of the prognostic factors and outcomes in early cervical cancer patients under going radical hysterectomy[J].Gynecol Oncol,2004,93(2):458-464.
[6]VinhňHung V,Bourgain C,Vlastos G,et al.Prognost ic value of histopathology and trends in cervical cancer:a SEER population study[J].BMC Cance,2007,237(1):164-169
[7]Chakravarti A,Noll E,Black PM,et al.Quantitatively determined surviving expression levels are of prognostic value in human glimas[J].J Clin Oncol,2002,20(4):1063-1068.
[8]Chan PG,Sung H Y,Sawaya GF,et al.Changes in cervical cancer incidence af t er three decades of screening US women less than 30years old[J].Orig Res,2006,61(6):15-25.
[9]Mandelb latt JS,Lawrence WE,Womack SM,et al.Benefits and costs of u sing HPV testing to screen for cervical cancer[J].JAMA,2002,287(18):2372-2381.