苗药乌桕酚性成分研究
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摘要
目的:研究苗药乌桕的酚性成分。方法:综合利用各种色谱方法对苗药乌桕的乙醇提取物进行分离纯化,基于波谱数据并结合文献对比的方法鉴定所分离化合物的结构。结果:从乌桕的乙醇提取物中共分离鉴定出9个酚性成分,其结构分别为5,6,7,8-四甲氧基香豆素(1)、6,7,8-三甲氧基香豆素(2)、7-O-甲基东莨菪内酯(3)、东莨菪内酯(4)、3,3′-O-二甲基鞣花酸-4-O-α-L-鼠李糖苷(5)、3,3′-O-二甲基鞣花酸(6)、栗木酯苷(7)、3,3′-bisdemethylpinoresinol(8)和没食子酸乙酯(9)。结论:化合物5、7、8均为首次从乌桕中分离得到。
Objective:To study the phenolic compounds from Sapium sebiferum.Methods:Various column chromatographic methods were employed to obtain pure compounds from the ethanol extract of S.sebiferum.Spectral data was used for structure elucidation by comparison with literature data.Results:Nine compounds in total were obtained,and identified as 5,6,7,8-tetramethoxycoumarin(1),6,7,8-trimethoxycoumarin(2),6,7-dimethoxycoumarin(3),scopoletin(4),3,3′-di-O-methylellagicacid-4′-O-α-L-rhamnopyranoside(5),3,3′-di-O-methylellagic acid(6),aviculin(7),3,3′-bisdemethylpinoresinol(8),ethyl gallate(9),respectively.Conclusion:Compounds 5,7,8 were isolated from this plant for the first time.
Objective:To study the phenolic compounds from Sapium sebiferum.Methods:Various column chromatographic methods were employed to obtain pure compounds from the ethanol extract of S.sebiferum.Spectral data was used for structure elucidation by comparison with literature data.Results:Nine compounds in total were obtained,and identified as 5,6,7,8-tetramethoxycoumarin(1),6,7,8-trimethoxycoumarin(2),6,7-dimethoxycoumarin(3),scopoletin(4),3,3′-di-O-methylellagicacid-4′-O-α-L-rhamnopyranoside(5),3,3′-di-O-methylellagic acid(6),aviculin(7),3,3′-bisdemethylpinoresinol(8),ethyl gallate(9),respectively.Conclusion:Compounds 5,7,8 were isolated from this plant for the first time.
引文
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[16]赵倩,刘钫,李清娟,等.月季花化学成分研究[J].中草药,2012,43(8):1484-1488.
[2]金久宁,黄晶晶,钱学射.乌桕的植物文化与经济价值[J].北京林业大学学报:社会科学版,2014,13(2):32-36.
[3]贾敏如,李星炜.中国民族药志要[M].北京:中国医药科技出版社,2005:540.
[4]GAO RX,SU ZS,YIN YB,et al.Germplasm,chemical constituents,biological activities,utilization,and controle of Chinese tallow(Triadica sebifera(L.)Small)[J].Biological Invasions,2016(18):809-829.
[5]柳润辉,陈丽莉,孔令义.乌桕树皮中的鞣花酸衍生物[J].中国药科大学学报,2002,33(5):370-373.
[6]高莉,田华,吕培军,等.乌桕叶化学成分研究[J].中国中药杂志,2015,40(8):1518-1522.
[7]FU R,ZHANG YT,GUO YR,et al.Antioxidant and anti-inflammatory activities of the phenolic extracts of Sapium sebiferum(L.)Roxb.Leaves[J].Journal of Ethnopharmacology,2013,147(2):517-524.
[8]图斯库,张树军,李涛,等.臭椿树根化学成分研究[J].中草药,2015,46(10):1426-1430.
[9]漆淑华,吴大刚,罗晓东.桂林乌桕中的香豆素和鞣花酸类化合物[J].天然产物研究与开发,2004,16(4):297-299.
[10]陈建新,黄深惠,王英,等.半边莲化学成分研究[J].中药材,2010,33(11):1721-1724.
[11]ADFA M,YOSHIMURA T,KOMURA K,et al.Antitermite activities of coumarin derivatives and scopoletin from Protium javanicum Burm.f.[J].Journal of Chemical Ecology,2010(36):720-726.
[12]YE G,PENG H,FAN MS,et al.Ellagic acid derivatives from the stem bark of Dipentodon sinicus[J].Chemistry of Natural Compounds,2007,43(2):125-128.
[13]唐文照,丁杏苞,辛一周.板栗花中一个新木脂苷类化合物[J].药学学报,2004,39(7):531-533.
[14]KIM HJ,WOO ER,PARK H.A novel ligan and flavonoids from Polygonum aviculare[J].Journal of Natural Products,1994,57(5):581-586.
[15]李玲,李晓帆,吴慧星,等.麻枫树种子中抗氧化活性成分的研究[J].中草药,2010,41(12):1932-1936.
[16]赵倩,刘钫,李清娟,等.月季花化学成分研究[J].中草药,2012,43(8):1484-1488.