杜仲有效成分在帕金森病治疗中的药理作用研究进展
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摘要
帕金森病(Parkinson’s Disease, PD)是中老年人常见的神经系统变性疾病,其发病可受年龄、遗传和环境等因素影响,其主要病理机制为大脑黑质致密部多巴胺能神经元的病变缺失。保护多巴胺能神经元是行之有效的方法之一,脑内炎症反应、氧化应激等均可导致神经细胞的损伤。杜仲是常用补益中药,具有明确的神经保护作用,临床常用于PD的治疗,对近年杜仲及其有效成分在PD治疗中的药理作用研究进展做一综述,以期为杜仲在防治PD方面的开发应用提供一定线索。
Parkinson's disease(PD) is a common neurodegenerative disease in the elderly people. Its pathogenesis can be affected by age, heredity and environment. Its main pathological mechanism is the loss of dopaminergic neurons in the substantia nigra.Protecting dopaminergic neurons is one of the effective methods. Inflammatory reaction and oxidative stress in brain can lead to damage of nerve cells. Eucommia ulmoides Oliv. is precious tonic herbs of traditional Chinese medicine with definite neuroprotective effect. It is commonly used in the treatment of PD in clinic. In this paper, the pharmacological effects and effective components in the treatment of PD in recent years are studied. This review will provide a clue for the development and application of Eucommia ulmoides Oliv. in the prevention and treatment of PD.
Parkinson's disease(PD) is a common neurodegenerative disease in the elderly people. Its pathogenesis can be affected by age, heredity and environment. Its main pathological mechanism is the loss of dopaminergic neurons in the substantia nigra.Protecting dopaminergic neurons is one of the effective methods. Inflammatory reaction and oxidative stress in brain can lead to damage of nerve cells. Eucommia ulmoides Oliv. is precious tonic herbs of traditional Chinese medicine with definite neuroprotective effect. It is commonly used in the treatment of PD in clinic. In this paper, the pharmacological effects and effective components in the treatment of PD in recent years are studied. This review will provide a clue for the development and application of Eucommia ulmoides Oliv. in the prevention and treatment of PD.
引文
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[2] Jiang P, Dickson D W. Parkinson's disease:experimental models and reality[J]. Acta Neuropathologica, 2017, 135(Suppl 2):1-20.
[3] Fling B W, Dale M L, Curtze C, et al. Associations between mobility, cognition and callosal integrity in people with parkinsonism[J]. Neur Clin, 2016, 11(C):415-422.
[4]翚达康,胡玉英.从肾论治帕金森病的中医药研究进展[J].湖南中医杂志, 2018, 38(9):189-191.
[5]武燕.补肾养肝息风方药治疗肝肾阴虚型帕金森病疗效观察[J].中医临床研究, 2016(25):13-15.
[6]陆征宇,赵虹,汪涛,等.补肾疏肝方药治疗肝肾阴虚型帕金森病伴发轻中度抑郁障碍[J].中国实验方剂学杂志, 2013(24):324-328.
[7]张改,沈晓明.马云枝教授从肝辨治帕金森病经验简析[J].中医药学报, 2016, 44(3):86-88.
[8]窦维华,刁丽梅.补肾活血汤治疗帕金森病的临床研究[J].长春中医药大学学报, 2010, 26(4):501-502
[9]王娟娟,秦雪梅,高晓霞,等.杜仲化学成分、药理活性和质量控制现状研究进展[J]. 2017, 48(15):3228-3237.
[10]陈宗元,黄春丽,官检发,等.帕金森病的流行病学、发病机制及药物的研究进展[J].海峡药学, 2018(3):48-50.
[11] Reeve A, Simcox E, Turnbull D. Ageing and Parkinson's disease:why is advancing age the biggest risk factor?[J].Ag Res Rev, 2014, 14(100):19-30.
[12]耿全现.非痴呆帕金森病患者轻度认知障碍与发病年龄和疾病阶段的关系[J].现代预防医学, 2012, 39(12):3190-3192.
[13] Jiang H, Song N, Wang J, et al. Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra[J]. Neurochem Int, 2007, 51(1):32-36.
[14] Moldzio R, Radad K, Duvigneau J C, et al. Glutamateinduced cell death and formation of radicals can be reduced by lisuride in mesencephalic primary cell culture[J]. J Neur Transm, 2006, 113(9):1095-1105.
[15] Anantharam V, Lehrmann E, Kanthasamy A, et al.Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells:Relevance to oxidative damage in Parkinson's Disease[J]. Neurochem Int, 2007, 50(6):834-847.
[16] Thomas T, Timmer M, Cesnulevicius K, et al. MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation--relevance in a mouse model of Parkinson's disease[J]. J Neurochem, 2010, 105(5):2039-2052.
[17] Blum D, Torch S, Lambeng N, et al.Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP:contribution to the apoptotic theory in Parkinson's disease[J]. Progr Neurobiol, 2001, 65(2):135-172.
[18]熊珮,陈忻,张楠.帕金森病病理机制及中药防治帕金森病实验研究进展[J].中国中药杂志, 2012, 37(5):686-691.
[19]罗丕舵,贾刘云,王倩,等.中医药治疗帕金森病的研究进展[J].中医临床研究, 2017, 9(1):138-140.
[20]窦维华,刁丽梅.补肾活血汤治疗帕金森病的临床研究[J].长春中医药大学学报, 2010, 26(4):501-502.
[21]陈为龙,徐容富,孔令周,等.天麻钩藤饮联合西药治疗帕金森病随机平行对照研究[J].实用中医内科杂志,2015, 29(6):87-88.
[22] Wang J, Li Y, Huang W H, et al. The protective effect of aucubin from eucommia ulmoides against status epilepticus by inducing autophagy and inhibiting necroptosis[J]. Am J Chin Med, 2017, 45(3):1-17.
[23] Kwon S H, Ma S X, Hong S I, et al.Eucommia ulmoides Oliv. bark. attenuates 6-hydroxydopamine-induced neuronal cell death through inhibition of oxidative stress in SH-SY5Y cells[J]. J Ethnopharm, 2014, 152(1):173-182.
[24] Hu W, Wang G, Li P, et al. Neuroprotective effects of macranthoin G from Eucommia ulmoides against hydrogen peroxide-induced apoptosis in PC12 cells via inhibiting NF-κB activation[J]. Chem Biol Interact,2014, 224(13):108-116.
[25] Luo D, Terry C T, Yang L H, et al. Anti-inflammatory activity of iridoid and catechol derivatives from Eucommia ulmoides Oliver[J]. ACS Chem Neurosci,2014, 5(9):855-866.
[26] Kwon S H, Ma S X, Hwang J Y, et al. The antiinflammatory activity of Eucommia ulmoides Oliv. bark.involves NF-κB suppression and Nrf2-dependent HO-1induction in BV-2 microglial cells[J]. Biomol Ther,2016, 24(3):268-282.
[27] Kim H Y, Kim J K, Choi J H, et al. Hepatoprotective effect of pinoresinol on carbon tetrachloride–induced hepatic damage in mice[J]. J Pharmacol Sci, 2010, 112(1):105-112.
[28] Shen W J, Qi R B, Zhang J, et al. Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons[J]. Brain Res Bull,2012, 88:487.
[29] Kupeli E, Tatli II, Akdemir AS, et al. Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. cx Bentham[J]. J Ethnopharmacol,2007, 110(3):444-450.
[30] Dimitrova P, Kostadinova E, Milanova V, et al. Antiinflammatory properties of extracts and compounds isolated from Verbascum xanthophoeniceum Griseb[J].Phytother Res, 2012, 26(11):1681-1687.
[31] Georgiev M, Pastore S, Lulli D, et al. Verbascum xanthophoeniceum-derived phenylethanoid glycosides are potent inhibitors of inflammatory chemokines in dormant and interferon-gamma-stimulated human keratinocytes[J]. J Ethnopharmacol, 2012, 144(3):754-760.
[32]史卉妍,何鑫,欧阳冬生,等.京尼平苷及其衍生物的药效学研究进展[J].中国药学杂志, 2006, 41(1):4-6.
[33] Halliwell.Oxidants and the central nervous system:some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke[J]. Acta Neurol Scand Suppl, 1989, 80(126):23-33.
[34]马山,孙金杰,王欣,等.杜仲乙醇提取物对脑老化模型小鼠血中氧化应激指标的影响[J].国际药学研究杂志, 2016, 43(5):922-930.
[35] Lin J, Fan Y J, Mehl C, et al. Eucommia ulmoides Oliv.antagonizes H2O2-induced rat osteoblastic MC3T3-E1apoptosis by inhibiting expressions of caspases 3, 6, 7,and 9[J]. J Zhejiang Univ-Sci B(Biomed&Biotechnol),2011, 12(1):47-54.
[36] Sato Y, Itagaki S, Kurokawa T, et al. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid[J]. Int J Pharm, 2011, 403(1-2):136-138.
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