肺部菌群和肠道菌群在两种常见肺疾病中作用的研究进展
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摘要
哮喘、慢性阻塞性肺疾病(COPD)是常见高发的肺部疾病,相关发病机制尚待阐明。近年来,菌群对哮喘、COPD的发生发展的作用越来越引起重视。本文梳理了近期肺部菌群和肠道菌群在哮喘、COPD中的作用及机制相关文献,分别从肺部菌群和肠道菌群的角度,分析它们对哮喘、COPD的作用机制以及肺部菌群和肠道菌群之间相互调控的联系,以期进一步深入了解菌群在常见肺部疾病中的意义,为寻找更有效的防治哮喘、COPD的作用靶点或者分子提供相关可借鉴的思路。
Asthma and chronic obstructive pulmonary disease(COPD) are common high-risk lung diseases, the related pathogenesis of which remains to be elucidated. Recent studies have found that flora plays an important role in the development of asthma and COPD. In this paper, we reviewed the recent literatures on the role and mechanisms of pulmonary flora and intestinal flora in the development of asthma and COPD. In order to further understand the significance of the flora in common lung diseases and provide relevant ideas for finding more effective targets or molecules for the prevention and treatment of asthma and COPD, we analyzed the effects of flora on asthma and COPD from the perspective of pulmonary flora and intestinal flora, respectively.
Asthma and chronic obstructive pulmonary disease(COPD) are common high-risk lung diseases, the related pathogenesis of which remains to be elucidated. Recent studies have found that flora plays an important role in the development of asthma and COPD. In this paper, we reviewed the recent literatures on the role and mechanisms of pulmonary flora and intestinal flora in the development of asthma and COPD. In order to further understand the significance of the flora in common lung diseases and provide relevant ideas for finding more effective targets or molecules for the prevention and treatment of asthma and COPD, we analyzed the effects of flora on asthma and COPD from the perspective of pulmonary flora and intestinal flora, respectively.
引文
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[8] Huang YJ,Nariya S,Harris JM,et al.The airway microbiome in patients with severe asthma:Associations with disease features and severity[J].J Allergy Clin Immunol,2015,136(4):874-884.
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[11] Li N,Qiu R,Yang Z,et al.Sputum microbiota in severe asthma patients:Relationship to eosinophilic inflammation[J].Respir Med,2017,131:192-198.
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[25] Wang Z,Bafadhel M,Haldar K,et al.Lung microbiome dynamics in COPD exacerbations[J].Eur Respir J,2016,47(4):1082-1092.
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[27] Nos P,Domenech E.Management of Crohn′s disease in smokers:Is an alternative approach necessary?[J].World J Gastroenterol,2011,17(31):3567-3574.
[28] Mahid SS,Minor KS,Soto RE,et al.Smoking and inflammatory bowel disease:A meta-analysis[J].Mayo Clin Proc,2006,81(11):1462-1471.
[29] Ekbom A,Brandt L,Granath F,et al.Increased risk of both ulcerative colitis and Crohn′s disease in a population suffering from COPD[J].Lung,2008,186(3):167-172.
[30] Opstelten JL,Plassais J,van Mil SW,et al.Gut microbial diversity is reduced in smokers with Crohn′s disease[J].Inflamm Bowel Dis,2016,22(9):2070-2077.
[31] Keely S,Hansbro PM.Lung-gut cross talk:A potential mechanism for intestinal dysfunction in patients with COPD[J].Chest,2014,145(2):199-200.
[32] Rutten EPA,Lenaerts K,Buurman WA,et al.Disturbed intestinal integrity in patients with COPD:Effects of activities of daily living[J].Chest,2014,145(2):245-252.
[33] Molloy MJ,Bouladoux N,Belkaid Y.Intestinal microbiota:Shaping local and systemic immune responses[J].Semin Immunol,2012,24(1):58-66.
[34] Nishio J,Honda K.Immunoregulation by the gut microbiota[J].Cell Mol Life Sci,2012,69(21):3635-3650.
[35] Zhang MQ,Wan Y,Jin Y,et al.Cigarette smoking promotes inflammation in patients with COPD by affecting the polarization and survival of Th/Tregs through up-regulation of muscarinic receptor 3 and 5 expression[J].PLoS One,2014,9(11):e112350.
[36] Traves SL,Donnelly LE.Th17 cells in airway diseases[J].Curr Mol Med,2008,8(5):416-426.
[37] Wang H,Ying H,Wang S,et al.Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease[J].Clin Respir J,2015,9(3):330-341.
[38] Wang H,Peng W,Weng Y,et al.Imbalance of Th17/Treg cells in mice with chronic cigarette smoke exposure[J].Int Immunopharmacol,2012,14(4):504-512.
[39] Ottiger M,Nickler M,Steuer C,et al.Gut,microbiota-dependent trimethylamine- N -oxide is associated with long-term all-cause mortality in patients with exacerbated chronic obstructive pulmonary disease[J].Nutrition,2018,45:135-141.
[40] Senthil M,Brown M,Xu DZ,et al.Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple-organ dysfunction syndrome:Validating studies in a porcine model[J].J Trauma,2006,60(5):958-965.
[41] Chen LW,Chen PH,Hsu CM.Commensal microflora contribute to host defense against Escherichia coli pneumonia through Toll-like receptors[J].Shock,2011,36(1):67-75.
[42] Harb H,van Tol EA,Heine H,et al.Neonatal supplementation of processed supernatant from Lactobacillus rhamnosus GG improves allergic airway inflammation in mice later in life[J].Clin Exp Allergy,2013,43(3):353-364.
[43] Sze MA,Tsuruta M,Yang SW,et al.Changes in the bacterial microbiota in gut,blood,and lungs following acute LPS instillation into mice lungs[J].PLoS One,2014,9(10):e111228.
[44] Dominguez JA,Vithayathil PJ,Khailova L,et al.Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia[J].Shock,2011,36(4):381-389.
[45] YIN Mei,LIU Zhenuo,MENG Jingru,et al.Influence of oral cephalosporin drugs on intestinal flora in pneumococcal pneumonia rat[J].China Med Herald,2015,12(28):9-13.(in Chinese) 尹梅,刘振国,孟静茹,等.口服头孢菌素类药物对肺炎链球菌肺炎大鼠肠道菌群的影响[J].中国医药导报,2015,12(28):9-13.
[2] 史琦,王辛秋,孔艳华,等.浅述慢性阻塞性肺疾病与肠道菌群微生态失衡的关系[J].世界中西医结合杂志,2016,11(5):732-736.
[3] Moffatt MF,Cookson W.The lung microbiome in health and disease[J].Clin Med(Lond),2017,17(6):525-529.
[4] Huebinger RM,Smith AD,Zhang Y,et al.Variations of the lung microbiome and immune response in mechanically ventilated surgical patients[J].PLoS One,2018,13(10):e0205788.
[5] MA Chen,ZHANG Heping.Probiotic,intestinal microbiota and human health[J].Sci Technol Rev,2017,35(21):14-25.(in Chinese) 马晨,张和平.益生菌、肠道菌群与人体健康[J].科技导报,2017,35(21):14-25.
[6] Hilty M,Burke C,Pedro H,et al.Disordered microbial communities in asthmatic airways[J].PLoS One,2010,5(1):e8578.
[7] Huang YJ,Nelson CE,Brodie EL,et al.Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma[J].J Allergy Clin Immunol,2011,127(2):372-381.
[8] Huang YJ,Nariya S,Harris JM,et al.The airway microbiome in patients with severe asthma:Associations with disease features and severity[J].J Allergy Clin Immunol,2015,136(4):874-884.
[9] Marri PR,Stern DA,Wright AL,et al.Asthma-associated differences in microbial composition of induced sputum[J].J Allergy Clin Immunol,2013,131(2):346-352.
[10] Simpson JL,Daly J,Baines KJ,et al.Airway dysbiosis:Haemophilus influenzae and Tropheryma in poorly controlled asthma[J].Eur Respir J,2016,47(3):792-800.
[11] Li N,Qiu R,Yang Z,et al.Sputum microbiota in severe asthma patients:Relationship to eosinophilic inflammation[J].Respir Med,2017,131:192-198.
[12] Barcik W,Pugin B,Westermann P,et al.Histamine-secreting microbes are increased in the gut of adult asthma patients[J].J Allergy Clin Immunol,2016,138(5):1491-1494.
[13] Barnig C,Martin C.Asthma and the microbiome[J].Rev Mal Respir,2018.pii:S0761-8425(17)31022.
[14] Shukla SD,Budden KF,Neal R,et al.Microbiome effects on immunity,health and disease in the lung[J].Clin Transl Immunol,2017,6(3):e133.
[15] Johnson CC,Ownby DR.The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases[J].Transl Res,2017,179:60-70.
[16] Korpela K,Salonen A,Virta LJ,et al.Intestinal microbiome is related to lifetime antibiotic use in finnish pre-school children[J].Nat Commun,2016,7:10410.
[17] Okba AM,Saber SM,Abdel-Rehim AS,et al.Fecal microbiota profile in atopic asthmatic adult patients[J].Eur Ann Allergy Clin Immunol,2018,50(3):117-124.
[18] Russell SL,Gold MJ,Hartmann M,et al.Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma[J].EMBO Rep,2012,13(5):440-447.
[19] Trompette A,Gollwitzer ES,Yadava K,et al.Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis[J].Nat Med,2014,20(2):159-166.
[20] Garcha DS,Thurston SJ,Patel AR,et al.Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD[J].Thorax,2012,67(12):1075-1080.
[21] Garcia-Nuňez M,Millares L,Pomares X,et al.Severity-related changes of bronchial microbiome in chronic obstructive pulmonary disease[J].J Clin Microbiol,2014.52(12):4217-4223.
[22] Rutebemberwa A,et al.Novosphingobium and its potential role in chronic obstructive pulmonary diseases:Insights from microbiome studies[J].PLoS One,2014.9(10):e111150.
[23] Sze MA,Dimitriu PA,Hayashi S,et al.The lung tissue microbiome in chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2012,185(10):1073-1080.
[24] Bautista MV,Chen Y,Ivanova VS,et al.IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells[J].J Immunol,2009,183(3):2159-2166.
[25] Wang Z,Bafadhel M,Haldar K,et al.Lung microbiome dynamics in COPD exacerbations[J].Eur Respir J,2016,47(4):1082-1092.
[26] Sze MA,Hogg JC,Sin DD.Bacterial microbiome of lungs in COPD[J].Int J Chron Obstruct Pulmon Dis,2014,9:229-238.
[27] Nos P,Domenech E.Management of Crohn′s disease in smokers:Is an alternative approach necessary?[J].World J Gastroenterol,2011,17(31):3567-3574.
[28] Mahid SS,Minor KS,Soto RE,et al.Smoking and inflammatory bowel disease:A meta-analysis[J].Mayo Clin Proc,2006,81(11):1462-1471.
[29] Ekbom A,Brandt L,Granath F,et al.Increased risk of both ulcerative colitis and Crohn′s disease in a population suffering from COPD[J].Lung,2008,186(3):167-172.
[30] Opstelten JL,Plassais J,van Mil SW,et al.Gut microbial diversity is reduced in smokers with Crohn′s disease[J].Inflamm Bowel Dis,2016,22(9):2070-2077.
[31] Keely S,Hansbro PM.Lung-gut cross talk:A potential mechanism for intestinal dysfunction in patients with COPD[J].Chest,2014,145(2):199-200.
[32] Rutten EPA,Lenaerts K,Buurman WA,et al.Disturbed intestinal integrity in patients with COPD:Effects of activities of daily living[J].Chest,2014,145(2):245-252.
[33] Molloy MJ,Bouladoux N,Belkaid Y.Intestinal microbiota:Shaping local and systemic immune responses[J].Semin Immunol,2012,24(1):58-66.
[34] Nishio J,Honda K.Immunoregulation by the gut microbiota[J].Cell Mol Life Sci,2012,69(21):3635-3650.
[35] Zhang MQ,Wan Y,Jin Y,et al.Cigarette smoking promotes inflammation in patients with COPD by affecting the polarization and survival of Th/Tregs through up-regulation of muscarinic receptor 3 and 5 expression[J].PLoS One,2014,9(11):e112350.
[36] Traves SL,Donnelly LE.Th17 cells in airway diseases[J].Curr Mol Med,2008,8(5):416-426.
[37] Wang H,Ying H,Wang S,et al.Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease[J].Clin Respir J,2015,9(3):330-341.
[38] Wang H,Peng W,Weng Y,et al.Imbalance of Th17/Treg cells in mice with chronic cigarette smoke exposure[J].Int Immunopharmacol,2012,14(4):504-512.
[39] Ottiger M,Nickler M,Steuer C,et al.Gut,microbiota-dependent trimethylamine- N -oxide is associated with long-term all-cause mortality in patients with exacerbated chronic obstructive pulmonary disease[J].Nutrition,2018,45:135-141.
[40] Senthil M,Brown M,Xu DZ,et al.Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple-organ dysfunction syndrome:Validating studies in a porcine model[J].J Trauma,2006,60(5):958-965.
[41] Chen LW,Chen PH,Hsu CM.Commensal microflora contribute to host defense against Escherichia coli pneumonia through Toll-like receptors[J].Shock,2011,36(1):67-75.
[42] Harb H,van Tol EA,Heine H,et al.Neonatal supplementation of processed supernatant from Lactobacillus rhamnosus GG improves allergic airway inflammation in mice later in life[J].Clin Exp Allergy,2013,43(3):353-364.
[43] Sze MA,Tsuruta M,Yang SW,et al.Changes in the bacterial microbiota in gut,blood,and lungs following acute LPS instillation into mice lungs[J].PLoS One,2014,9(10):e111228.
[44] Dominguez JA,Vithayathil PJ,Khailova L,et al.Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia[J].Shock,2011,36(4):381-389.
[45] YIN Mei,LIU Zhenuo,MENG Jingru,et al.Influence of oral cephalosporin drugs on intestinal flora in pneumococcal pneumonia rat[J].China Med Herald,2015,12(28):9-13.(in Chinese) 尹梅,刘振国,孟静茹,等.口服头孢菌素类药物对肺炎链球菌肺炎大鼠肠道菌群的影响[J].中国医药导报,2015,12(28):9-13.
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