miRNA在自身免疫病中对趋化作用调控的研究进展
摘要
miRNA是一类分子长度为20～24个核苷酸的微小RNA,通常在转录后水平调控靶基因的降解或抑制翻译。趋化因子是具有趋化吸引性的蛋白质,而免疫细胞可以表达不同的趋化因子受体,因此趋化因子能够吸引免疫细胞到达炎症部位,参与自身免疫病的发生和发展。越来越多的证据显示miRNA在自身免疫病中发挥重要作用,文章将对目前已知的miRNA在自身免疫病中对趋化作用的调控的研究进展作一综述。
引文
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[2] Bernstein E,Caudy AA,Hammond SM,et al.Role for a bidentate ribonuclease in the initiation step of RNA interference[J].Nature,2001,409:363-366.
[3] Schwarz DS,Hutvágner G,Du T,et al.Asymmetry in the assembly of the RNAi enzyme complex[J].Cell,2003,115(2):199-208.
[4] Ballarino M,Pagano F,Girardi E,et al.Coupled RNA processing and transcription of intergenic primary microRNAs[J].Mol Cell Biol,2009,29(20):5632-5638.
[5] Cascieri MA,Springer MS.The chemokine/chemokine-receptor family:Potential and progress for therapeutic intervention[J].Curr Opin Chem Biol,2000,4(4):420-427.
[6] Nd CK,Hromas R.Chemokine regulation of normal and pathologic immune responses[J].Stem Cells,2001,19(5):388-396.
[7] Gueraudearellano M,Smith KM,Godlewski J,et al.Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity[J].Brain,2011,134(Pt 12):3578-3589.
[8] O'Connell RM,Kahn D,Gibson WS,et al.MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development[J].Immunity,2010,33(4):607-619.
[9] Elmesmari A,Fraser AR,Wood C,et al.MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in rheumatoid arthritis[J].Rheumatology (Oxford),2016,55(11):2056-2065.
[10] Hu J,Zhai C,Hu J,et al.MiR-23a inhibited IL-17-mediated proinflammatory mediators expression via targeting IKKα in articular chondrocytes[J].Int Immunopharmacol,2017,43:1-6.
[11] Yang S,Yang Y.Downregulation of microRNA221 decreases migration and invasion in fibroblast like synoviocytes in rheumatoid arthritis[J].Mol Med Rep,2015,12(2):2395-2401.
[12] Zhao X,Tang Y,Qu B,et al.MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus[J].Arthritis Rheum,2010,62(11):3425-3435.
[13] Dominguezgutierrez PR,Ceribelli A,Satoh M,et al.Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus[J].Arthritis Res Ther,2014,16(1):R20.
[14] Dominguezgutierrez PR,Ceribelli A,Satoh M,et al.Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone,mycophenolate mofetil,or hydroxychloroquine,except in a high STAT1 subset[J].Arthritis Res Ther,2014,16(1):R23.
[15] Cheng W,Chen G.Chemokines and chemokine receptors in multiple sclerosis[J].Mediators Inflamm,2014,2014(23):659206.
[16] Fischer HJ,Schweingruber N,Lühder F,et al.The potential role of T cell migration and chemotaxis as targets of glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis[J].Mol Cell Endocrinol,2013,380(1-2):99-107.
[17] Cerutti C,Edwards LJ,de Vries HE,et al.MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium[J].Sci Rep,2017,7:45284.
[18] Zhu S,Pan W,Song XY,et al.The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2,TAB3 and IKK-α[J].Nat Med,2012,18(7):1077-1086.
[19] Pivarcsi A,St?hle M,Sonkoly E.Genetic polymorphisms altering microRNA activity in psoriasis-a key to solve the puzzle of missing heritability?[J].Exp Dermatol,2014,23(9):620-624.
[20] Xu N,Meisgen F,Butler LM,et al.MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40[J].J Immunol,2013,190(2):678-688.
[21] Liu XF,Wang RQ,Hu B,et al.MicroRNA miR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10[J].Clin Immunol,2016,164:106-113.
[22] Huang Z,Shi T,Zhou Q,et al.MiR-141 regulates colonic leukocytic trafficking by targeting CXCL12β during murine colitis and human Crohn's disease[J].Gut,2014,63(8):1247-1257.
[23] Cheng X,Zhang X,Su J,et al.MiR-19b downregulates intestinal SOCS3 to reduce intestinal inflammation in Crohn's disease[J].Sci Rep,2015,5:10397.
[24] Fornari TA,Donate PB,Assis AF,et al.Comprehensive survey of miRNA-mRNA interactions reveals that Ccr7 and Cd247 (CD3 zeta) are posttranscriptionally controlled in pancreas infiltrating T lymphocytes of non-obese diabetic (NOD) mice[J].PLoS One,2015,10(11):e0142688.
[25] Dai R,Ahmed SA.MicroRNA,a new paradigm for understanding immunoregulation,inflammation,and autoimmune diseases[J].Transl Res,2011,157(4):163-179.