微生态制剂联合蓝光照射对黄疸新生儿免疫功能及黄疸指数的影响
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摘要
目的探讨微生态制剂联合蓝光照射对黄疸新生儿免疫功能和黄疸指数的影响。方法选取本院2016年1月至2017年1月收治的黄疸新生儿162例为研究对象,采用随机数表法将其分为观察组和对照组,每组各81例,观察组患儿采取微生态制剂联合蓝光照射治疗,对照组患儿采取单纯蓝光照射治疗,对比两组患儿免疫功能指标和黄疸指数变化情况。结果治疗5 d后,两组患儿免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)水平均显著高于本组治疗前(P_均<0.05),C反应蛋白(C reactive protein,CRP)水平及黄疸指数均显著低于本组治疗前(P_均<0.05);且观察组患儿IgA、IgG水平均显著高于同期对照组(P_均<0.05),CRP水平及黄疸指数均显著低于同期对照组(P_均<0.05)。观察组患儿黄疸消退时间显著短于对照组(P <0.001),不良反应发生率显著低于对照组(P=0.034)。结论微生态制剂联合蓝光照射可以明显改善黄疸新生儿的免疫功能,降低黄疸指数,且不良反应发生率较低。
Objective To investigate the effect of microecological preparation combined with blue light irradiation on immune function and jaundice index of newborn with jaundice. Method 162 neonates with jaundice were selected from January 2016 to January 2017 in our hospital, they were divided into observation group(81 cases) and control group(81 cases) by random table method,newborns in observation group were treated with microecological preparation combined with blue light irradiation, while newborns in control group were treated with simple blue light irradiation. The changes of immune function indexes and jaundice index were compared between the two groups. Result After 5 days of treatment, the levels of immunoglobulin A(IgA) and immunoglobulin G(IgG) in both groups were signi?cantly higher than those before treatment(P_(all)< 0.05), the levels of C reactive protein(CRP) and jaundice index were signi?cantly lower than those before treatment(P_(all)< 0.05), and the levels of IgA and IgG in observation group were signi?cantly higher than those in control group(P_(all)< 0.05). The levels of CRP and jaundice index in observation group were signi?cantly lower than those in control group(P_(all)< 0.05). The regression time of jaundice in observation group was signi?cantly shorter than that in control group(P < 0.001), and the incidence of adverse reactions in observation group was signi?cantly lower than that in control group(P = 0.034). Conclusion Microecological preparation combined with blue light irradiation can obviously improve the immune function of newborn with jaundice and reduce the jaundice index, and the incidence of adverse reactions is lower.
Objective To investigate the effect of microecological preparation combined with blue light irradiation on immune function and jaundice index of newborn with jaundice. Method 162 neonates with jaundice were selected from January 2016 to January 2017 in our hospital, they were divided into observation group(81 cases) and control group(81 cases) by random table method,newborns in observation group were treated with microecological preparation combined with blue light irradiation, while newborns in control group were treated with simple blue light irradiation. The changes of immune function indexes and jaundice index were compared between the two groups. Result After 5 days of treatment, the levels of immunoglobulin A(IgA) and immunoglobulin G(IgG) in both groups were signi?cantly higher than those before treatment(P_(all)< 0.05), the levels of C reactive protein(CRP) and jaundice index were signi?cantly lower than those before treatment(P_(all)< 0.05), and the levels of IgA and IgG in observation group were signi?cantly higher than those in control group(P_(all)< 0.05). The levels of CRP and jaundice index in observation group were signi?cantly lower than those in control group(P_(all)< 0.05). The regression time of jaundice in observation group was signi?cantly shorter than that in control group(P < 0.001), and the incidence of adverse reactions in observation group was signi?cantly lower than that in control group(P = 0.034). Conclusion Microecological preparation combined with blue light irradiation can obviously improve the immune function of newborn with jaundice and reduce the jaundice index, and the incidence of adverse reactions is lower.
引文
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[15]Maimburg RD,Olsen J,Sun Y.Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy[J].Epilepsy Res,2016,124(1):67-72.
[16]Mreihil K,Benth J?,Stensvold HJ,et al.Phototherapy is commonly used for neonatal jaundice but greater control is needed to avoid toxicity in the most vulnerable infants[J].Acta Paediatrica,2017,107(4):611-619.
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[18]Melli LC,do Carmo-Rodrigues MS,Araújo-Filho HB,et al.Intes tinal microbiota and allergic diseases:A systematic review[J].Allergol Immunopathol(Madr),2016,44(2):177.
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[20]Lichtenstein L,Avnibiron I,Benbassat O.The current place of probiotics and prebiotics in the treatment of pouchitis[J].Best Pract Res Clin Gastroenterol,2016,30(1):73-80.
[2]孙红丽,宋永芹,王永霞.新生儿黄疸的临床表现分型与核黄疸的危害[J].医学信息,2016,29(31):245-246.
[3]张红琴,陈俊.光疗后避光部位经皮胆红素测定值对血总胆红素的预测价值[J].广东医学,2018,39(S1):144-145.
[4]师淑锋.冷光源蓝光联合布拉氏酵母菌散对新生儿黄疸预后的影响[J].中国医学前沿杂志(电子版),2017,9(2):159-162.
[5]张晓蕊,曾超美,刘捷.强光疗治疗新生儿高胆红素血症的疗效及安全性[J].中国当代儿科杂志,2016,18(3):195-200.
[6]臧凯丽,江岩,孙勇,等.微生态制剂调节便秘、腹泻人群肠道菌群结构与产短链脂肪酸关键菌属的相关性[J].食品科学,2018,9(5):155-165.
[7]中华医学会儿科学分会新生儿学组.新生儿黄疸诊疗原则的专家共识[J].中华儿科杂志,2010,48(9):685-686.
[8]Simkiss D,Martin R.Neonatal jaundice[J].J Trop Pediatr,2016,58(5):339-340.
[9]Greco C,Arnolda G,Boo NY,et al.Neonatal Jaundice in Lowand Middle-Income Countries:Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat[J].Neonatology,2016,110(3):172-180.
[10]Moawad EM,Abdallah EA,Ali YZ.Perceptions,practices,and traditional beliefs related to neonatal jaundice among Egyptian mothers:A cross-sectional descriptive study[J].Medicine,2016,95(36):e4804.
[11]赵丹丹,黄迪,高翔羽.经皮胆红素测定在新生儿黄疸中的应用[J].中华儿科杂志,2017,55(1):74-77.
[12]Stevenson DK,Bhutani VK.Neonatal Hyperbilirubinemia in Preterm Neonates[J].Clin Perinatol,2016,43(2):215-232.
[13]徐世进,胡宁.换血疗法对新生儿黄疸生化指标及血液内环境的影响[J].罕少疾病杂志,2018,25(1):73-75.
[14]Mreihil K,Nakstad B,Stensvold H J,et al.Uniform national guidelines do not prevent wide variations in the clinical application of phototherapy for neonatal jaundice[J].Acta Paediatrica,2017,107(4):620-627.
[15]Maimburg RD,Olsen J,Sun Y.Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy[J].Epilepsy Res,2016,124(1):67-72.
[16]Mreihil K,Benth J?,Stensvold HJ,et al.Phototherapy is commonly used for neonatal jaundice but greater control is needed to avoid toxicity in the most vulnerable infants[J].Acta Paediatrica,2017,107(4):611-619.
[17]Feng JR,Wang F,Qiu X,et al.Efficacy and safety of probioticsupplemented triple therapy for eradication of Helicobacter pylori in children:a systematic review and network metaanalysis[J].Eur J Clin Pharmacol,2017(8):1-10.
[18]Melli LC,do Carmo-Rodrigues MS,Araújo-Filho HB,et al.Intes tinal microbiota and allergic diseases:A systematic review[J].Allergol Immunopathol(Madr),2016,44(2):177.
[19]Sarangi NR,Babu LK,Kumar A,et al.Effect of dietary supplem entation of prebiotic,probiotic,and synbiotic on growth performance and carcass characteristics of broiler chickens[J].Vet World,2016,9(3):313-319.
[20]Lichtenstein L,Avnibiron I,Benbassat O.The current place of probiotics and prebiotics in the treatment of pouchitis[J].Best Pract Res Clin Gastroenterol,2016,30(1):73-80.